diff --git a/instructor/providers/bedrock/utils.py b/instructor/providers/bedrock/utils.py
index f6a8cd5c7..b5814d5ca 100644
--- a/instructor/providers/bedrock/utils.py
+++ b/instructor/providers/bedrock/utils.py
@@ -225,10 +225,14 @@ def _to_bedrock_content_items(content: Any) -> list[dict[str, Any]]:
             {"text":"..."}
             {"image":{"format":"jpeg|png|gif|webp","source":{"bytes": <raw bytes>}}}
             {"document":{"format":"pdf|csv|doc|docx|xls|xlsx|html|txt|md","name":"...","source":{"bytes": <raw bytes>}}}
+            {"cachePoint":{"type":"default"}}
+            Any other valid Bedrock ContentBlock dict (guardContent, toolUse,
+            toolResult, audio, video, reasoningContent, etc.)
 
     Note:
-      - We do not validate or normalize Bedrock-native image/document blocks here.
-        Caller is responsible for providing valid 'format' and raw 'bytes'.
+      - We do not validate or normalize Bedrock-native blocks here.
+        Caller is responsible for providing valid structure.
+        The Bedrock API will reject malformed content blocks.
     """
     # Plain string
     if isinstance(content, str):
@@ -269,7 +273,10 @@ def _to_bedrock_content_items(content: Any) -> list[dict[str, Any]]:
                     items.append(p)
                     continue
 
-                raise ValueError(f"Unsupported dict content for Bedrock: {p}")
+                # Pass-through any other Bedrock-native content block (cachePoint,
+                # guardContent, toolUse, toolResult, audio, video, etc.)
+                items.append(p)
+                continue
 
             # Plain string elements inside list
             if isinstance(p, str):
diff --git a/tests/llm/test_bedrock/test_bedrock_native_passthrough.py b/tests/llm/test_bedrock/test_bedrock_native_passthrough.py
index c79d35d47..f1b167938 100644
--- a/tests/llm/test_bedrock/test_bedrock_native_passthrough.py
+++ b/tests/llm/test_bedrock/test_bedrock_native_passthrough.py
@@ -1,4 +1,7 @@
 from __future__ import annotations
+
+import pytest
+
 from instructor.providers.bedrock.utils import _to_bedrock_content_items
 
 
@@ -18,3 +21,49 @@ def test_bedrock_native_document_passthrough(tiny_pdf_bytes: bytes):
     native = {"document": {"format": "pdf", "source": {"bytes": tiny_pdf_bytes}}}
     items = _to_bedrock_content_items([native])
     assert items[0] == native
+
+
+def test_bedrock_native_cachepoint_passthrough():
+    """Regression test for #1954: cachePoint dicts must pass through."""
+    cache_point = {"cachePoint": {"type": "default"}}
+    items = _to_bedrock_content_items([cache_point])
+    assert items == [cache_point]
+
+
+def test_bedrock_native_cachepoint_with_ttl():
+    cache_point = {"cachePoint": {"type": "default", "ttl": "5m"}}
+    items = _to_bedrock_content_items([cache_point])
+    assert items == [cache_point]
+
+
+def test_bedrock_native_guard_content_passthrough():
+    guard = {"guardContent": {"text": {"text": "test content"}}}
+    items = _to_bedrock_content_items([guard])
+    assert items == [guard]
+
+
+@pytest.mark.parametrize(
+    "block",
+    [
+        {"cachePoint": {"type": "default"}},
+        {"guardContent": {"text": {"text": "check this"}}},
+        {"video": {"format": "mp4", "source": {"bytes": b"fake"}}},
+        {"audio": {"format": "mp3", "source": {"bytes": b"fake"}}},
+    ],
+    ids=["cachePoint", "guardContent", "video", "audio"],
+)
+def test_bedrock_native_content_block_passthrough(block: dict):
+    """All Bedrock-native content blocks should pass through unchanged."""
+    items = _to_bedrock_content_items([block])
+    assert items == [block]
+
+
+def test_mixed_content_with_cachepoint():
+    """Regression test for #1954: cachePoint mixed with text in real usage."""
+    content = [
+        {"text": "Say hello world."},
+        {"cachePoint": {"type": "default"}},
+        {"text": "This is a test message."},
+    ]
+    items = _to_bedrock_content_items(content)
+    assert items == content