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Merge pull request #35 from Sydney-Informatics-Hub/main
Add thyroid cancer participant
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participants/thyroid-cancer.md

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---
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title: Thyroid Cancer Research Group, The University of Sydney
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description:
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toc: false
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type: ABLeS Participant
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---
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## Project title
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Applying single cell RNA sequencing to understand the immune landscape of thyroid cancer, with the goal of identifying therapeutic targets and biomarkers.
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## Collaborators and funding
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- Thyroid Cancer Research Group, Faculty of Medicine and Health, University of Sydney
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- Kolling Institute of Medical Research
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- Sydney Informatics Hub, University of Sydney
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## Contact(s)
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- Dr Martyn Bullock <[email protected]>
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- Dr Georgie Samaha <[email protected]>
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- Mr Frederick Jaya <[email protected]>
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## Project description and aims
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Understanding the immune composition of thyroid tumours is critical for identifying novel therapeutic targets and predictive biomarkers. Leveraging single-cell RNA sequencing, this study will profile the tumour immune microenvironment at high resolution, enabling the discovery of cell-type-specific expression patterns and pathway dysregulation.
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This project will be implemented on NCI's Gadi HPC, leveraging the open source [nf-core/scrnaseq](https://nf-co.re/scrnaseq) pipeline, and will produce public interactive notebooks for quality control, cell type annotation, differential expression, and biomarker discovery.
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## How is ABLeS supporting this work?
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This work is supported through the production bioinformatics scheme provided by ABLeS. The support includes and 10 KSUs per quarter.
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## Expected outputs enabled by participation in ABLeS
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A public scalable computational workflow and analytical notebooks for single-cell RNA sequencing in cancer cohorts that can be deployed on NCI Gadi.
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