diff --git a/README.md b/README.md
index f7d0930..099374e 100644
--- a/README.md
+++ b/README.md
@@ -135,7 +135,7 @@ Ensure a value is a number is within a given range:
 Vex.valid? value, number: [greater_than_or_equal_to: 0, less_than: 10]
 ```
 
-This validation can be skipped for `nil` or blank values by including 
+This validation can be skipped for `nil` or blank values by including
 `allow_nil: true` or `allow_blank: true` respectively in the options.
 
 See the documentation on `Vex.Validators.Number` for details
@@ -155,7 +155,7 @@ Ensure a value is a valid UUID string in a given format:
 Vex.valid? value, uuid: [format: :hex]
 ```
 
-This validation can be skipped for `nil` or blank values by including 
+This validation can be skipped for `nil` or blank values by including
 `allow_nil: true` or `allow_blank: true` respectively in the options.
 
 See the documentation on `Vex.Validators.Uuid` for details
@@ -349,6 +349,16 @@ You can also use `valid?` directly from the Module:
 user |> User.valid?
 ```
 
+**Performance optimization tip:**
+
+You can get a significant performance boost on validation when using:
+```elixir
+use Vex.Struct, precompile_validator_lookup: true
+```
+This comes at the cost of precomputing the validator lookup at compile time.
+Runtime modification of the validator lookup from updating the Vex config (i.e., `config :vex, sources: [..]`)
+will not have an effect if you are using this method.
+
 ### In Keyword Lists
 
 In your list, just include a `:_vex` entry and use `Vex.valid?/1`:
diff --git a/lib/vex.ex b/lib/vex.ex
index 1257fde..9976f32 100644
--- a/lib/vex.ex
+++ b/lib/vex.ex
@@ -58,7 +58,7 @@ defmodule Vex do
   end
 
   defp result(data, attribute, name, options) do
-    v = validator(name)
+    v = Vex.Validator.Lookup.lookup(data, name)
 
     if Validator.validate?(data, options) do
       result = data |> extract(attribute, name) |> v.validate(data, options)
diff --git a/lib/vex/extract.ex b/lib/vex/extract.ex
index 7f3a61c..42b2ba5 100644
--- a/lib/vex/extract.ex
+++ b/lib/vex/extract.ex
@@ -38,6 +38,15 @@ defmodule Vex.Extract.Struct do
         def blank?(struct), do: struct |> Map.from_struct() |> map_size == 0
       end
 
+      defimpl Vex.Validator.Lookup, for: __MODULE__ do
+        def lookup(%{__struct__: module}, name) do
+          case(module.__vex_validator__(name)) do
+            {:error, :not_enabled} -> Vex.validator(name)
+            {:ok, validator} -> validator
+          end
+        end
+      end
+
       defimpl Vex.Extract, for: __MODULE__ do
         def settings(%{__struct__: module}) do
           module.__vex_validations__
diff --git a/lib/vex/struct.ex b/lib/vex/struct.ex
index ff85fd9..4b729cf 100644
--- a/lib/vex/struct.ex
+++ b/lib/vex/struct.ex
@@ -1,9 +1,11 @@
 defmodule Vex.Struct do
   @moduledoc false
 
-  defmacro __using__(_) do
+  defmacro __using__(opts) do
     quote do
       @vex_validations %{}
+      @precompile_validator_lookup unquote(Keyword.get(opts, :precompile_validator_lookup, false))
+      @precompiled_validator_lookup %{}
       @before_compile unquote(__MODULE__)
       import unquote(__MODULE__)
       def valid?(self), do: Vex.valid?(self)
@@ -14,6 +16,14 @@ defmodule Vex.Struct do
     quote do
       def __vex_validations__(), do: @vex_validations
 
+      if @precompile_validator_lookup do
+        def __vex_validator__(name) do
+          {:ok, Map.fetch!(@precompiled_validator_lookup, name)}
+        end
+      else
+        def __vex_validator__(_name), do: {:error, :not_enabled}
+      end
+
       require Vex.Extract.Struct
       Vex.Extract.Struct.for_struct()
     end
@@ -22,6 +32,27 @@ defmodule Vex.Struct do
   defmacro validates(name, validations \\ []) do
     quote do
       @vex_validations Map.put(@vex_validations, unquote(name), unquote(validations))
+      if @precompile_validator_lookup do
+        @precompiled_validator_lookup Enum.reduce(
+                                        unquote(validations) |> List.wrap(),
+                                        @precompiled_validator_lookup,
+                                        fn
+                                          {validator_name, _validator_opts}, lookup ->
+                                            Map.put_new_lazy(
+                                              lookup,
+                                              validator_name,
+                                              fn -> Vex.validator(validator_name) end
+                                            )
+
+                                          fun, lookup when is_function(fun) ->
+                                            Map.put_new_lazy(
+                                              lookup,
+                                              :by,
+                                              fn -> Vex.validator(:by) end
+                                            )
+                                        end
+                                      )
+      end
     end
   end
 end
diff --git a/lib/vex/validator/lookup.ex b/lib/vex/validator/lookup.ex
new file mode 100644
index 0000000..1761c24
--- /dev/null
+++ b/lib/vex/validator/lookup.ex
@@ -0,0 +1,21 @@
+defprotocol Vex.Validator.Lookup do
+  @doc """
+  Determines the lookup method of validator modules based on the datastructure at hand.
+  Defaults to `Vex.validator/1`.
+
+  `Vex.Struct` types can leverage a more optimized mechanism when initialized by using
+  ```
+  use Vex.Struct, precompile_validator_lookup: true
+  ```
+  This performs the validator lookup once, and pushes a lookup data structure into the module at compile time.
+  """
+
+  @fallback_to_any true
+  def lookup(to_validate, name)
+end
+
+defimpl Vex.Validator.Lookup, for: Any do
+  def lookup(_to_validate, name) do
+    Vex.validator(name)
+  end
+end
diff --git a/lib/vex/validator/source.ex b/lib/vex/validator/source.ex
index 1e8d967..2b384de 100644
--- a/lib/vex/validator/source.ex
+++ b/lib/vex/validator/source.ex
@@ -35,3 +35,9 @@ defimpl Vex.Validator.Source, for: List do
     Keyword.get(list, name)
   end
 end
+
+defimpl Vex.Validator.Source, for: Map do
+  def lookup(map, name) do
+    Map.get(map, name)
+  end
+end