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RELEASES.md

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## 2025 Releases
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### [v2025-06-27](https://github.com/DiseaseOntology/HumanDiseaseOntology/tree/v2025-06-27)
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### [v2025-08-01](https://github.com/DiseaseOntology/HumanDiseaseOntology/tree/v2025-08-01)
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This release of the Human Disease Ontology includes 11,895 disease classes, 9,585 with textual definitions (80.6%). Terms with Spanish translation have increased to include 10,837 labels (91.1%), 11,714 synonyms (60.8%), and 2,145 definitions (22.4%).
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This release of the Human Disease Ontology includes 11,926 disease classes, 9,619 with textual definitions (80.7%).
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Diseases revised and expanded include hereditary spastic paraplegias, cherubisms, transient neonatal diabetes mellituses, infantile onset multisystem autoimmune diseases, and autoinflammation, panniculitis, and dermatosis syndromes.
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Diseases revised and expanded include viral infectious diseases, monilethrix diseases, congenital mirror movement disorders, familial isolated hypoparathyroidisms, congenital ptoses, and myofibrillar myopathies.
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Additional revisions were made to X-linked mental retardation-hypotonic facies syndrome-1, PAPA syndrome, X-linked intellectual disability-short stature-overweight syndrome, colitis, autosomal dominant intellectual developmental disorder 34, congenital heart disease, congenital muscular dystrophy with cataracts and intellectual disability, paroxysmal nonkinesigenic dyskinesia 3, renal tubular acidosis, syndromic X-linked intellectual disability 5, blastoma, pituitary blastoma, pulmonary blastoma, cellular myxoid liposarcoma, mixed liposarcoma, and myxoid liposarcoma.
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Newly added diseases include Mulvihill-Smith syndrome and hereditary spastic paraplegia 92.
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Newly added diseases include CASGID syndrome, Fliedner-Zweier syndrome, Kariminejad neurodevelopmental syndrome, Ramon syndrome, autosomal recessive distal renal tubular acidosis 3 with or without sensorineural hearing loss, autosomal recessive proximal renal tubular acidosis, coarctation of the aorta, immunodeficiency 130 with HPV-related verrucosis, kyphomelic dysplasia, mitochondrial axonal Charcot-Marie-Tooth disease, neurodevelopmental disorder with seizures and gingival overgrowth, proximal renal tubular acidosis, and retinopathy sensory neuropathy syndrome.
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Translation files now include 10,887 labels (91.3%), 11,472 synonyms (59.4%), and 3,763 definitions (39.1%) in Spanish. Also, a diff procedure has now been implemented to identify new text for translation and avoid including translations of the original text where it has been modified or removed.
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## Obsoleted diseases
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ID | label | term replaced by
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---|---|---
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DOID:0081119 | benign familial infantile seizures 6 | autosomal dominant nocturnal frontal lobe epilepsy 4 (DOID:0060685)
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DOID:5709 | mixed-type liposarcoma | myxoid liposarcoma (DOID:5363)
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**Full Changelog**: https://github.com/DiseaseOntology/HumanDiseaseOntology/compare/v2025-06-27...v2025-08-01
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| | OWL | OBO | JSON |
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| --- | --- | --- | --- |
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| Disease Ontology | [doid.owl](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid.owl) | [doid.obo](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid.obo) | [doid.json](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid.json) |
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| Human DO | [HumanDO.owl](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/HumanDO.owl) | [HumanDO.obo](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/HumanDO.obo) | |
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| DO Non-Classified | [doid-non-classified.owl](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid-non-classified.owl) | [doid-non-classified.obo](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid-non-classified.obo) | [doid-non-classified.json](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid-non-classified.json) |
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| DO Merged | [doid-merged.owl](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid-merged.owl) | [doid-merged.obo](https://raw.githubusercontent.com/DiseaseOntology/HumanDiseaseOntology/v2025-08-01/src/ontology/doid-merged.obo) | |
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### [v2025-06-27](https://github.com/DiseaseOntology/HumanDiseaseOntology/tree/v2025-06-27)
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This release of the Human Disease Ontology includes 11,895 disease classes, 9,585 with textual definitions (80.6%). Terms with Spanish translation have increased to include 10,837 labels (91.1%), 11,714 synonyms (60.8%), and 2,145 definitions (22.4%).
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Diseases revised and expanded include viral infectious diseases, monilethrix diseases, congenital mirror movement disorders, familial isolated hypoparathyroidisms, congenital ptoses, and myofibrillar myopathies.
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Newly added diseases include Mulvihill-Smith syndrome and hereditary spastic paraplegia 92.
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## Obsoleted diseases
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ID | label | term replaced by
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---|---|---
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DOID:0081119 | benign familial infantile seizures 6 | autosomal dominant nocturnal frontal lobe epilepsy 4 (DOID:0060685)
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**Full Changelog**: https://github.com/DiseaseOntology/HumanDiseaseOntology/compare/v2025-05-30...v2025-06-27
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| | OWL | OBO | JSON |

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