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docs: use British English in docs
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README.md

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@@ -225,7 +225,7 @@ This project uses `renv` for reproducible dependencies. Install/restore everythi
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Rscript 000_install_dependencies.R
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```
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### Manual install (optional)
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### Manual installation (optional)
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If you prefer to install packages manually instead of using `renv`:
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#### Bioconductor
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Session info recorded in `results/session_info.txt`. All random processes use fixed seeds.
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## License
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## Licence
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MIT
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REPRODUCIBILITY.md

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## What’s Included
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- **Code**: analysis scripts in `scripts/` and an orchestrator in `run_all.R`.
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- **Version pinning**: `renv.lock` pins CRAN + Bioconductor package versions.
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- **Precomputed outputs**: key figures and tables are committed under `results/` for convenience and fast verification.
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- **Pre-computed outputs**: key figures and tables are committed under `results/` for convenience and quick verification.
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## From a Clean Checkout (Recommended)
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Run these commands from the repository root:
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## From a clean checkout (recommended)
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Run these commands from the repository root (i.e., a fresh clone):
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```sh
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# Restore/install pinned dependencies (CRAN + Bioconductor)
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Rscript run_all.R
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```
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## Data Download Behavior
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## Data Download Behaviour
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The data download step (`scripts/00_get_data.R`) is **idempotent**:
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- If `data/counts_raw.rds` and `data/metadata.rds` already exist, it will **skip** re-downloading.
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- To force a fresh download from GEO:
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FORCE_DOWNLOAD=true Rscript scripts/00_get_data.R
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```
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## Network Dependencies
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## Network dependencies
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Some steps require network access:
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- GEO download (via `GEOquery`) in `scripts/00_get_data.R`
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- KEGG pathway annotation (via KEGG REST) in `scripts/06_enrichment.R`

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