diff --git a/dev/compare_tables.R b/dev/compare_tables.R
index 6e99dea..6f3ac35 100644
--- a/dev/compare_tables.R
+++ b/dev/compare_tables.R
@@ -7,7 +7,7 @@ if (length(args) != 2) {
 
 reference_dir <- args[[1]]
 generated_dir <- args[[2]]
-relative_tolerance <- 2e-5
+relative_tolerance <- 5e-4  # 0.05% — allows cross-platform floating point drift in DESeq2
 zero_tolerance <- 1e-12
 effect_size_absolute_tolerance <- 1e-6