Dead link in documentation - MPC plugin

[zx8754]

This takes us to GitHub pm file
https://github.com/Ensembl/VEP_plugins/blob/release/115/MPC.pm

This one is dead
https://ftp.broadinstitute.org/pub/ExAC_release/release1/regional_missense_constraint/

Where can I download this file?

fordist_constraint_official_mpc_values.txt.gz

[nakib103]

Hi @zx8754,

Thanks for your query.

The plugin seems to have created a bit of a time ago and the required data file is no longer available at that location. The MPC score is available at gnomAD website according to the paper.

We will check if it is possible to update the plugin to use the files from there.

Best regards,
Nakib