Wildcard method targets lose their descriptor after being remapped. For example, *()Lnet/minecraft/client/renderer/ShaderInstance; remaps to * in a mixin targeting GameRenderer (tested with 1.21.1 and 1.20.1, should affect most versions around that timeframe). I would expect it to maintain the same structure but replace the class name with the intermediary name.
This might be related to the changes in #139.