DataFxns/csharp/local/AntibodySequenceLiabilities.yaml at e400bd4bbb0c17ef1a91a8c81f284f1f926cbe2e · Glysade/DataFxns · GitHub

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id: 01010160-093b-55c7-746b-8a3c148111b7
name: Antibody Sequence Liabilities
description: Create a set of boolean columns indicating the presence or absence of predefined antibody sequence liabilities.  A column illustrating the sequence and the identified liability locations is also created.
category: Biopolymer
version: 1.1.0
serviceName: AntibodySequenceLiabilities
serviceUri: glysade.csharp
executorId: Glysade.CSharpDataFxn
inputFields:
- control:
    id: sequenceColumn
    label: Select sequence column (must contain protein sequences)
    type: columnselect
    filters:
    - dataType: string
      contentType: chemical/x-sequence
    - dataType: binary
      contentType: chemical/x-genbank
    validationRules:
    - type: required
    multi: !!bool false
  request:
    id: sequenceColumn
    dataType: string
    selectorType: column
- control:
    id: outputColumn
    label: Annotated output column name
    type: text
    validationRules:
    - type: required
      message: Enter a name for the annotated output column.
  request:
    id: outputColumn
    dataType: string
    data: Annotated Liabilities
- control:
    id: patterns
    label: Sequence liabilities
    type: select
    multi: !!bool true
    options:
    - text: Asparagine Deamidation
      value: Asparagine Deamidation,(?=(N[GSTNH]))
    - text: Aspartic Acid Fragmentation
      value: Aspartic Acid Fragmentation,DP
    - text: Aspartic Acid Isomerization
      value: Aspartic Acid Isomerization,(?=(D[GSTDH]))
    - text: Cysteine
      value: Cysteine,C
    - text: Lysine N-glycation
      value: Lysine N-glycation,(?<=(K[DE]|[DE]K))
    - text: N-glycosylation
      value: N-glycosylation,N[^P][TS]
    - text: N-terminal Glutamic Acid
      value: N-terminal Glutamic Acid,^E
    - text: Oxidation
      value: Oxidation,[MW]
    validationRules:
    - type: required
  request:
    id: patterns
    dataType: list(string)
    data:
    - Asparagine Deamidation,(?=(N[GSTNH]))
    - Aspartic Acid Fragmentation,DP
    - Aspartic Acid Isomerization,(?=(D[GSTDH]))
    - Cysteine,C
    - Lysine N-glycation,(?<=(K[DE]|[DE]K))
    - N-glycosylation,N[^P][TS]
    - N-terminal Glutamic Acid,^E
    - Oxidation,[MW]
- control:
    id: ctrlColor
    label: Select color
    type: color
  request:
    id: ctrlColor
    dataType: string
    data: '#ff0000'
assembly: PublisherCore
tags:
- color: '#dddddd'
  text: MAB
- color: '#AFC9E1'
  text: annotation
- color: '#337abc'
  text: sequence
updateBehavior: automatic
maximumOutputColumns: !!int 10
maximumOutputTables: !!int 0
chemistryFunction: !!bool false
outputFields:
- id: sequenceColumn
  name: Sequence column
  source: inputField
  type: default
- id: outputColumn
  name: Annotated sequence output column
  source: inputField
  type: default
- id: patterns
  name: Selected liabilities
  source: inputField
  type: default
- id: ctrlColor
  name: Color
  source: inputField
  type: color
allowedClients:
- Analyst
- WebPlayer
demoUrl:
limitBy: none
minimumChartsVersion: 4.4.0.0
confirmSubmit: