diff --git a/.bazelrc b/.bazelrc
index f791d2fee6322..2d8b8911c45dd 100644
--- a/.bazelrc
+++ b/.bazelrc
@@ -170,6 +170,7 @@ build:release --compilation_mode=opt
 build:release-lto --copt=-flto=thin
 build:release-lto --linkopt=-flto=thin
 build:release-lto --@rules_rust//rust/settings:lto=thin
+build:release-lto --@//misc/bazel/platforms:xlang_lto=True
 
 # Builds from `main` or tagged builds.
 #
diff --git a/misc/bazel/cargo-gazelle/BUILD.bazel b/misc/bazel/cargo-gazelle/BUILD.bazel
index df79fac97baca..6ccf8714ce5b3 100644
--- a/misc/bazel/cargo-gazelle/BUILD.bazel
+++ b/misc/bazel/cargo-gazelle/BUILD.bazel
@@ -90,7 +90,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = ["-Copt-level=3"],
+    rustc_flags = ["-Copt-level=3"] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [":cargo_gazelle"] + all_crate_deps(normal = True),
 )
diff --git a/misc/bazel/cargo-gazelle/src/config.rs b/misc/bazel/cargo-gazelle/src/config.rs
index dd1a02d794334..246829d1ff54b 100644
--- a/misc/bazel/cargo-gazelle/src/config.rs
+++ b/misc/bazel/cargo-gazelle/src/config.rs
@@ -13,6 +13,7 @@ use std::collections::BTreeMap;
 use guppy::graph::PackageMetadata;
 use std::sync::LazyLock;
 
+use crate::ToBazelDefinition;
 use crate::targets::{AdditiveContent, RustTestSize};
 
 const KEY_NAME: &str = "cargo-gazelle";
@@ -315,3 +316,21 @@ impl CommonConfig {
         &self.rustc_env
     }
 }
+
+/// Values that are mirrored in `/misc/bazel/platforms/BUILD.bazel`.
+#[derive(Debug, Copy, Clone)]
+pub enum ConfigSettingGroup {
+    XlangLtoEnabled,
+}
+
+impl ToBazelDefinition for ConfigSettingGroup {
+    fn format(&self, w: &mut dyn std::fmt::Write) -> Result<(), std::fmt::Error> {
+        match self {
+            ConfigSettingGroup::XlangLtoEnabled => {
+                write!(w, "\"@//misc/bazel/platforms:xlang_lto_enabled\"")?
+            }
+        }
+
+        Ok(())
+    }
+}
diff --git a/misc/bazel/cargo-gazelle/src/lib.rs b/misc/bazel/cargo-gazelle/src/lib.rs
index 0ac5ce200839c..f957e339c0239 100644
--- a/misc/bazel/cargo-gazelle/src/lib.rs
+++ b/misc/bazel/cargo-gazelle/src/lib.rs
@@ -11,7 +11,6 @@ use std::collections::{BTreeMap, VecDeque};
 use std::fmt::{self, Debug, Write};
 use std::rc::Rc;
 
-use crate::platforms::PlatformVariant;
 use crate::targets::RustTarget;
 
 pub mod args;
@@ -510,20 +509,21 @@ impl ToBazelDefinition for Glob {
 /// ```
 #[derive(Debug)]
 pub struct Select<T> {
-    entries: BTreeMap<PlatformVariant, T>,
+    entries: BTreeMap<String, T>,
     default: T,
 }
 
 impl<T> Select<T> {
-    pub fn new<E, I>(entires: I, default: E) -> Select<T>
+    pub fn new<E, I, J>(entires: I, default: E) -> Select<T>
     where
         E: Into<T>,
-        I: IntoIterator<Item = (PlatformVariant, E)>,
+        J: ToBazelDefinition,
+        I: IntoIterator<Item = (J, E)>,
     {
         Select {
             entries: entires
                 .into_iter()
-                .map(|(variant, entry)| (variant, entry.into()))
+                .map(|(variant, entry)| (variant.to_bazel_definition(), entry.into()))
                 .collect(),
             default: default.into(),
         }
@@ -538,7 +538,7 @@ impl<T: ToBazelDefinition> ToBazelDefinition for Select<T> {
         {
             let mut w = w.indent();
             for (variant, entry) in &self.entries {
-                variant.format(&mut w)?;
+                write!(w, "{variant}")?;
                 write!(w, ": ")?;
                 entry.format(&mut w)?;
                 writeln!(w, ",")?;
diff --git a/misc/bazel/cargo-gazelle/src/targets.rs b/misc/bazel/cargo-gazelle/src/targets.rs
index ac50cae55068f..37b576413267f 100644
--- a/misc/bazel/cargo-gazelle/src/targets.rs
+++ b/misc/bazel/cargo-gazelle/src/targets.rs
@@ -21,7 +21,7 @@ use std::collections::{BTreeMap, BTreeSet};
 use std::fmt::{self, Write};
 use std::str::FromStr;
 
-use crate::config::{CrateConfig, GlobalConfig};
+use crate::config::{ConfigSettingGroup, CrateConfig, GlobalConfig};
 use crate::context::CrateContext;
 use crate::platforms::PlatformVariant;
 use crate::rules::Rule;
@@ -382,8 +382,17 @@ impl RustBinary {
         let (paths, globs) = bin_config.common().compile_data();
         let compile_data = List::new(paths).concat_other(globs.map(Glob::new));
 
+        let xlang_lto_select: Select<List<QuotedString>> = Select::new(
+            [(
+                ConfigSettingGroup::XlangLtoEnabled,
+                vec![QuotedString::new("-Clinker-plugin-lto")],
+            )],
+            vec![],
+        );
+
         let env = Dict::new(bin_config.env());
-        let rustc_flags = List::new(bin_config.common().rustc_flags());
+        let rustc_flags =
+            List::new(bin_config.common().rustc_flags()).concat_other(xlang_lto_select);
         let rustc_env = Dict::new(bin_config.common().rustc_env());
 
         Ok(Some(RustBinary {
diff --git a/misc/bazel/platforms/BUILD.bazel b/misc/bazel/platforms/BUILD.bazel
index ab9f496160f2c..a36e79d836d05 100644
--- a/misc/bazel/platforms/BUILD.bazel
+++ b/misc/bazel/platforms/BUILD.bazel
@@ -16,7 +16,7 @@ support building Materialize for.
 """
 
 load("@bazel_skylib//lib:selects.bzl", "selects")
-load("@bazel_skylib//rules:common_settings.bzl", "string_flag")
+load("@bazel_skylib//rules:common_settings.bzl", "bool_flag", "string_flag")
 
 # A flag that we can specify on the command line to configure whether or not we
 # build with a sanitizer.
@@ -45,6 +45,28 @@ config_setting(
     flag_values = {":sanitizer": "hwaddress"},
 )
 
+bool_flag(
+    name = "xlang_lto",
+    build_setting_default = False,
+)
+
+config_setting(
+    name = "use_xlang_lto",
+    flag_values = {":xlang_lto": "True"},
+)
+
+# With our current toolchain setup, cross language LTO is only supported when building for Linux.
+#
+# See <https://github.com/rust-lang/rust/issues/60059> for macOS support.
+selects.config_setting_group(
+    name = "xlang_lto_enabled",
+    match_all = [
+        "@platforms//os:linux",
+        ":use_xlang_lto",
+    ],
+    visibility = ["//visibility:public"],
+)
+
 # We only want to use jemalloc if we're building for Linux and we're not using sanitizers.
 selects.config_setting_group(
     name = "use_jemalloc",
diff --git a/src/balancerd/BUILD.bazel b/src/balancerd/BUILD.bazel
index c0f1589f7aba8..ba100e1a6885d 100644
--- a/src/balancerd/BUILD.bazel
+++ b/src/balancerd/BUILD.bazel
@@ -179,7 +179,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         ":mz_balancerd",
diff --git a/src/catalog-debug/BUILD.bazel b/src/catalog-debug/BUILD.bazel
index e48f1037e0d27..83fb36f8d05ba 100644
--- a/src/catalog-debug/BUILD.bazel
+++ b/src/catalog-debug/BUILD.bazel
@@ -30,7 +30,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         "//src/adapter:mz_adapter",
diff --git a/src/clusterd/BUILD.bazel b/src/clusterd/BUILD.bazel
index 80d12fda92627..d8acd456aea6b 100644
--- a/src/clusterd/BUILD.bazel
+++ b/src/clusterd/BUILD.bazel
@@ -156,7 +156,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         ":mz_clusterd",
diff --git a/src/environmentd/BUILD.bazel b/src/environmentd/BUILD.bazel
index f4ce2bacdc89a..85e0f5a2d819b 100644
--- a/src/environmentd/BUILD.bazel
+++ b/src/environmentd/BUILD.bazel
@@ -793,7 +793,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         ":mz_environmentd",
diff --git a/src/fivetran-destination/BUILD.bazel b/src/fivetran-destination/BUILD.bazel
index cb9d31bb0de13..4f289df286a18 100644
--- a/src/fivetran-destination/BUILD.bazel
+++ b/src/fivetran-destination/BUILD.bazel
@@ -116,7 +116,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         ":mz_fivetran_destination",
diff --git a/src/frontegg-mock/BUILD.bazel b/src/frontegg-mock/BUILD.bazel
index 2010c60205b22..05b1b4b6f3e88 100644
--- a/src/frontegg-mock/BUILD.bazel
+++ b/src/frontegg-mock/BUILD.bazel
@@ -132,7 +132,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         ":mz_frontegg_mock",
diff --git a/src/interchange/BUILD.bazel b/src/interchange/BUILD.bazel
index 85f87278dbafa..62a5ca0987a13 100644
--- a/src/interchange/BUILD.bazel
+++ b/src/interchange/BUILD.bazel
@@ -126,7 +126,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         ":mz_interchange",
diff --git a/src/kafka-util/BUILD.bazel b/src/kafka-util/BUILD.bazel
index 596ba9de8e646..8f516f43b9d19 100644
--- a/src/kafka-util/BUILD.bazel
+++ b/src/kafka-util/BUILD.bazel
@@ -105,7 +105,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         ":mz_kafka_util",
diff --git a/src/lsp-server/BUILD.bazel b/src/lsp-server/BUILD.bazel
index 42e8c6441cda0..92ed03aa2efa1 100644
--- a/src/lsp-server/BUILD.bazel
+++ b/src/lsp-server/BUILD.bazel
@@ -144,7 +144,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.3.0",
     deps = [
         ":mz_lsp_server",
diff --git a/src/materialized/BUILD.bazel b/src/materialized/BUILD.bazel
index e7a832759be51..91ef68bc50469 100644
--- a/src/materialized/BUILD.bazel
+++ b/src/materialized/BUILD.bazel
@@ -30,7 +30,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         "//src/clusterd:mz_clusterd",
diff --git a/src/mz-debug/BUILD.bazel b/src/mz-debug/BUILD.bazel
index 9369a13247649..8c9a7b23b8dbf 100644
--- a/src/mz-debug/BUILD.bazel
+++ b/src/mz-debug/BUILD.bazel
@@ -30,7 +30,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.1.0",
     deps = [
         "//src/build-info:mz_build_info",
diff --git a/src/mz/BUILD.bazel b/src/mz/BUILD.bazel
index 94c6bbc96e83e..d1cf31776bc87 100644
--- a/src/mz/BUILD.bazel
+++ b/src/mz/BUILD.bazel
@@ -139,7 +139,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.3.0",
     deps = [
         ":mz",
diff --git a/src/orchestratord/BUILD.bazel b/src/orchestratord/BUILD.bazel
index 6766763d9e1ff..a1f513d98bd3f 100644
--- a/src/orchestratord/BUILD.bazel
+++ b/src/orchestratord/BUILD.bazel
@@ -123,7 +123,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         ":mz_orchestratord",
diff --git a/src/persist-cli/BUILD.bazel b/src/persist-cli/BUILD.bazel
index bd2ebca042256..461b08592925e 100644
--- a/src/persist-cli/BUILD.bazel
+++ b/src/persist-cli/BUILD.bazel
@@ -30,7 +30,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         "//src/http-util:mz_http_util",
diff --git a/src/pgtest/BUILD.bazel b/src/pgtest/BUILD.bazel
index bb1ba4c9c23ee..579767c23bdf6 100644
--- a/src/pgtest/BUILD.bazel
+++ b/src/pgtest/BUILD.bazel
@@ -90,7 +90,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         ":mz_pgtest",
diff --git a/src/s3-datagen/BUILD.bazel b/src/s3-datagen/BUILD.bazel
index 1a3311f67f466..3fa5e5c79d80e 100644
--- a/src/s3-datagen/BUILD.bazel
+++ b/src/s3-datagen/BUILD.bazel
@@ -30,7 +30,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         "//src/aws-util:mz_aws_util",
diff --git a/src/sqllogictest/BUILD.bazel b/src/sqllogictest/BUILD.bazel
index 4bc23413a33d5..859e4bc71c729 100644
--- a/src/sqllogictest/BUILD.bazel
+++ b/src/sqllogictest/BUILD.bazel
@@ -203,7 +203,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.1",
     deps = [
         ":mz_sqllogictest",
diff --git a/src/testdrive/BUILD.bazel b/src/testdrive/BUILD.bazel
index 1c56c294f3d29..288c2fd6712b9 100644
--- a/src/testdrive/BUILD.bazel
+++ b/src/testdrive/BUILD.bazel
@@ -165,7 +165,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.144.0-dev.0",
     deps = [
         ":mz_testdrive",
diff --git a/test/metabase/smoketest/BUILD.bazel b/test/metabase/smoketest/BUILD.bazel
index 44b01db9c00e4..04da01e3c741c 100644
--- a/test/metabase/smoketest/BUILD.bazel
+++ b/test/metabase/smoketest/BUILD.bazel
@@ -30,7 +30,10 @@ rust_binary(
     lint_config = ":lints",
     proc_macro_deps = [] + all_crate_deps(proc_macro = True),
     rustc_env = {},
-    rustc_flags = [],
+    rustc_flags = [] + select({
+        "@//misc/bazel/platforms:xlang_lto_enabled": ["-Clinker-plugin-lto"],
+        "//conditions:default": [],
+    }),
     version = "0.0.0",
     deps = [
         "//src/metabase:mz_metabase",