NeuroGuessr Web

Overview

NeuroGuessr Web is an interactive web application designed to help learning brain anatomy.

Features

• Atlas Selection: Choose from multiple brain atlases (AAL, Harvard-Oxford, Brodmann, Subcortical, Cerebellum ...).
• Game Modes:
  • Practice: attempts to find regions with feedback.
  • Streak: Count consecutive correct guesses until a mistake.
  • Time Attack: Find all regions of an atlas in a minimal time
• Visualization: Interactive brain viewer with axial, coronal, sagittal slices, and 3D rendering.

Website

• HTML, CSS, JavaScript

• Niivue: web-based visualization tool for neuroimaging [https://github.com/niivue/niivue]

• Data:

  • Brain Atlases:
    • Tissue classes
    • Harvard-Oxford : Probabilistic atlases covering 48 cortical and 21 subcortical structural areas, derived from structural data and segmentation (doi:10.1016/j.schres.2005.11.020, 10.1016/j.neuroimage.2006.01.021, 10.1176/appi.ajp.162.7.1256, 10.1016/j.biopsych.2006.06.027)
    • Destrieux Atlas, Sulcal-gyral parcellation (Ref : doi:10.1016/j.neuroimage.2010.06.010)
    • Allen Humain Brain Reference : 141 manually delineated regions per hemisphere (Ref : 10.1002/cne.24080)
    • Subcortical Registration of basal ganglia, red nucleus, amygdala, and hippocampus (Ref : https://www.nature.com/articles/s41597-019-0217-0)
    • Cerebellum Cerebellar Atlas in MNI152 space after normalization with FNIRT (FSL)
    • Thalamus nuclei
    • Hippocampus & amygdala subfields
    • Resting state functional networks : (Thomas Yeo, 7 and 17 networks)
    • White matter tracts (Xtract, FSL)
    • White matter (JHU) : "Tract probability maps in stereotaxic spaces: Analyses of white matter anatomy and tract-specific quantification". DOI https://doi.org/10.1016/j.neuroimage.2007.07.053
    • Arterial Atlas : "an atlas of brain arterial territories based on lesion distributions in 1,298 acute stroke patients. The atlas covers supra- and infra-tentorial regions and contains hierarchical segmentation levels created by a fusion of vascular and classical anatomical criteria. This deformable 3D digital atlas can be readily used by the clinical and research communities, enabling automatic and highly reproducible exploration of large-scaled data.". https://www.nature.com/articles/s41597-0
  • JSON Files: Label mappings for each atlas, used for region identification and display.

Usage

1. Install prerequisites

• Install Node.js. Neuroguessr has been tested with node 22.11 and node 24.0
• Install Postgresql and create a database. Don't worry, the tables will be created automatically at first launch

2. Configure your server

• copy backend/config-example.json to backend/config.json and change parameters accordingly
• copy frontend/config-example.json to frontend/config.json and change parameters accordingly
• (HTTPS only) Put your server certificates in server/server.crt and server/server.key

3. Run the following commands:

npm install
npm run build-frontend
npm run start-backend

License

This project is licensed under the GPLv3 License - see the [LICENSE] file for details.

Authors

Francois Ramon Joseph Benzakoun