diff --git a/bun.lock b/bun.lock
index 901f348ae97..ada82030746 100644
--- a/bun.lock
+++ b/bun.lock
@@ -4,6 +4,7 @@
     "": {
       "name": "ohif-monorepo-root",
       "dependencies": {
+        "@cornerstonejs/nifti-volume-loader": "^4.10.0",
         "execa": "8.0.1",
       },
       "devDependencies": {
@@ -52,7 +53,7 @@
     },
     "addOns/externals/devDependencies": {
       "name": "@externals/devDependencies",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@kitware/vtk.js": "34.15.1",
@@ -137,14 +138,14 @@
     },
     "addOns/externals/dicom-microscopy-viewer": {
       "name": "@externals/dicom-microscopy-viewer",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "dicom-microscopy-viewer": "0.48.6",
       },
     },
     "extensions/cornerstone": {
       "name": "@ohif/extension-cornerstone",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/adapters": "4.14.6",
@@ -170,8 +171,8 @@
         "@cornerstonejs/codec-openjpeg": "1.3.0",
         "@cornerstonejs/codec-openjph": "2.4.7",
         "@cornerstonejs/dicom-image-loader": "4.14.6",
-        "@ohif/core": "3.12.0-beta.110",
-        "@ohif/ui": "3.12.0-beta.110",
+        "@ohif/core": "3.12.0-beta.111",
+        "@ohif/ui": "3.12.0-beta.111",
         "dcmjs": "0.45.0",
         "dicom-parser": "1.8.21",
         "hammerjs": "2.0.8",
@@ -183,7 +184,7 @@
     },
     "extensions/cornerstone-dicom-pmap": {
       "name": "@ohif/extension-cornerstone-dicom-pmap",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/adapters": "4.14.6",
@@ -206,7 +207,7 @@
     },
     "extensions/cornerstone-dicom-rt": {
       "name": "@ohif/extension-cornerstone-dicom-rt",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "react-color": "2.19.3",
@@ -226,7 +227,7 @@
     },
     "extensions/cornerstone-dicom-seg": {
       "name": "@ohif/extension-cornerstone-dicom-seg",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/adapters": "4.14.6",
@@ -249,7 +250,7 @@
     },
     "extensions/cornerstone-dicom-sr": {
       "name": "@ohif/extension-cornerstone-dicom-sr",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/adapters": "4.14.6",
@@ -258,10 +259,10 @@
         "classnames": "2.5.1",
       },
       "peerDependencies": {
-        "@ohif/core": "3.12.0-beta.110",
-        "@ohif/extension-cornerstone": "3.12.0-beta.110",
-        "@ohif/extension-measurement-tracking": "3.12.0-beta.110",
-        "@ohif/ui": "3.12.0-beta.110",
+        "@ohif/core": "3.12.0-beta.111",
+        "@ohif/extension-cornerstone": "3.12.0-beta.111",
+        "@ohif/extension-measurement-tracking": "3.12.0-beta.111",
+        "@ohif/ui": "3.12.0-beta.111",
         "dcmjs": "0.45.0",
         "dicom-parser": "1.8.21",
         "hammerjs": "2.0.8",
@@ -271,7 +272,7 @@
     },
     "extensions/cornerstone-dynamic-volume": {
       "name": "@ohif/extension-cornerstone-dynamic-volume",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/core": "4.14.6",
@@ -293,16 +294,17 @@
     },
     "extensions/default": {
       "name": "@ohif/extension-default",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/calculate-suv": "1.1.0",
+        "@cornerstonejs/nifti-volume-loader": "4.14.6",
         "lodash.get": "4.4.2",
         "lodash.uniqby": "4.7.0",
       },
       "peerDependencies": {
-        "@ohif/core": "3.12.0-beta.110",
-        "@ohif/i18n": "3.12.0-beta.110",
+        "@ohif/core": "3.12.0-beta.111",
+        "@ohif/i18n": "3.12.0-beta.111",
         "dcmjs": "0.45.0",
         "dicomweb-client": "0.10.4",
         "prop-types": "15.8.1",
@@ -316,7 +318,7 @@
     },
     "extensions/dicom-microscopy": {
       "name": "@ohif/extension-dicom-microscopy",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/codec-charls": "1.2.3",
@@ -341,7 +343,7 @@
     },
     "extensions/dicom-pdf": {
       "name": "@ohif/extension-dicom-pdf",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "classnames": "2.5.1",
@@ -358,7 +360,7 @@
     },
     "extensions/dicom-video": {
       "name": "@ohif/extension-dicom-video",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "classnames": "2.5.1",
@@ -375,20 +377,20 @@
     },
     "extensions/measurement-tracking": {
       "name": "@ohif/extension-measurement-tracking",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
-        "@ohif/ui": "3.12.0-beta.110",
+        "@ohif/ui": "3.12.0-beta.111",
         "@xstate/react": "3.2.2",
         "xstate": "4.38.3",
       },
       "peerDependencies": {
         "@cornerstonejs/core": "4.14.6",
         "@cornerstonejs/tools": "4.14.6",
-        "@ohif/core": "3.12.0-beta.110",
-        "@ohif/extension-cornerstone-dicom-sr": "3.12.0-beta.110",
-        "@ohif/extension-default": "3.12.0-beta.110",
-        "@ohif/ui": "3.12.0-beta.110",
+        "@ohif/core": "3.12.0-beta.111",
+        "@ohif/extension-cornerstone-dicom-sr": "3.12.0-beta.111",
+        "@ohif/extension-default": "3.12.0-beta.111",
+        "@ohif/ui": "3.12.0-beta.111",
         "classnames": "2.5.1",
         "dcmjs": "0.45.0",
         "lodash.debounce": "4.0.8",
@@ -401,7 +403,7 @@
     },
     "extensions/test-extension": {
       "name": "@ohif/extension-test",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "classnames": "2.5.1",
@@ -418,7 +420,7 @@
     },
     "extensions/tmtv": {
       "name": "@ohif/extension-tmtv",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "classnames": "2.5.1",
@@ -435,7 +437,7 @@
     },
     "extensions/usAnnotation": {
       "name": "@ohif/extension-ultrasound-pleura-bline",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/core": "4.14.6",
@@ -487,7 +489,7 @@
     },
     "modes/basic": {
       "name": "@ohif/mode-basic",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
       },
@@ -508,7 +510,7 @@
     },
     "modes/basic-dev-mode": {
       "name": "@ohif/mode-basic-dev-mode",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next": "17.3.1",
@@ -528,7 +530,7 @@
     },
     "modes/basic-test-mode": {
       "name": "@ohif/mode-test",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next": "17.3.1",
@@ -550,7 +552,7 @@
     },
     "modes/longitudinal": {
       "name": "@ohif/mode-longitudinal",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next": "17.3.1",
@@ -574,7 +576,7 @@
     },
     "modes/microscopy": {
       "name": "@ohif/mode-microscopy",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next": "17.3.1",
@@ -586,7 +588,7 @@
     },
     "modes/preclinical-4d": {
       "name": "@ohif/mode-preclinical-4d",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
       },
@@ -605,7 +607,7 @@
     },
     "modes/segmentation": {
       "name": "@ohif/mode-segmentation",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next": "17.3.1",
@@ -650,7 +652,7 @@
     },
     "modes/tmtv": {
       "name": "@ohif/mode-tmtv",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next": "17.3.1",
@@ -671,7 +673,7 @@
     },
     "modes/usAnnotation": {
       "name": "@ohif/mode-ultrasound-pleura-bline",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/core": "4.14.6",
@@ -710,7 +712,7 @@
     },
     "platform/app": {
       "name": "@ohif/app",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "@cornerstonejs/codec-charls": "1.2.3",
@@ -789,7 +791,7 @@
     },
     "platform/cli": {
       "name": "@ohif/cli",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "bin": {
         "ohif-cli": "src/index.js",
       },
@@ -813,7 +815,7 @@
     },
     "platform/core": {
       "name": "@ohif/core",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "dcmjs": "0.45.0",
@@ -840,14 +842,14 @@
         "@cornerstonejs/codec-openjph": "2.4.7",
         "@cornerstonejs/core": "4.14.6",
         "@cornerstonejs/dicom-image-loader": "4.14.6",
-        "@ohif/ui": "3.12.0-beta.110",
+        "@ohif/ui": "3.12.0-beta.111",
         "cornerstone-math": "0.1.9",
         "dicom-parser": "1.8.21",
       },
     },
     "platform/i18n": {
       "name": "@ohif/i18n",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@babel/runtime": "7.28.2",
         "i18next-locize-backend": "2.2.2",
@@ -872,7 +874,7 @@
     },
     "platform/ui": {
       "name": "@ohif/ui",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@testing-library/react": "13.4.0",
         "browser-detect": "0.2.28",
@@ -923,7 +925,7 @@
     },
     "platform/ui-next": {
       "name": "@ohif/ui-next",
-      "version": "3.12.0-beta.110",
+      "version": "3.12.0-beta.111",
       "dependencies": {
         "@radix-ui/react-accordion": "1.2.11",
         "@radix-ui/react-checkbox": "1.3.2",
@@ -1251,6 +1253,8 @@
 
     "@cornerstonejs/labelmap-interpolation": ["@cornerstonejs/labelmap-interpolation@4.14.6", "", { "dependencies": { "@itk-wasm/morphological-contour-interpolation": "1.1.0", "itk-wasm": "1.0.0-b.165" }, "peerDependencies": { "@cornerstonejs/core": "4.14.6", "@cornerstonejs/tools": "4.14.6", "@kitware/vtk.js": "34.15.1" } }, "sha512-4yHUHryMvck1v4RC6AxNhGH6Y28sP7Y71dudWCfXtYuMY2bKkBfoumQhh+IvjczJTrURT9zgg9O5krKOQHe/fQ=="],
 
+    "@cornerstonejs/nifti-volume-loader": ["@cornerstonejs/nifti-volume-loader@4.15.0", "", { "dependencies": { "nifti-reader-js": "0.6.9" }, "peerDependencies": { "@cornerstonejs/core": "4.15.0" } }, "sha512-mbpdPB8zzfJ7Gnq0cx3ka1hE9VcWKU/So9OQQqk0HrQl03yB9uIIDu9GnvvNtX+IDZN7jkZWMbYHUJu7I2+BxA=="],
+
     "@cornerstonejs/polymorphic-segmentation": ["@cornerstonejs/polymorphic-segmentation@4.14.6", "", { "dependencies": { "@icr/polyseg-wasm": "0.4.0" }, "peerDependencies": { "@cornerstonejs/core": "4.14.6", "@cornerstonejs/tools": "4.14.6", "@kitware/vtk.js": "34.15.1" } }, "sha512-VPNaEbj2/sRv2Acn3m1NaPFECDGZJ8I9aNUC6+vg86aRbbJtDjGvqXUyqSPcW2rYGaWtnEx1RWCQhSE/5HfLOA=="],
 
     "@cornerstonejs/tools": ["@cornerstonejs/tools@4.14.6", "", { "dependencies": { "@types/offscreencanvas": "2019.7.3", "comlink": "4.4.2", "lodash.get": "4.4.2" }, "peerDependencies": { "@cornerstonejs/core": "4.14.6", "@kitware/vtk.js": "34.15.1", "@types/d3-array": "3.2.1", "@types/d3-interpolate": "3.0.4", "d3-array": "3.2.4", "d3-interpolate": "3.0.1", "gl-matrix": "3.4.3" } }, "sha512-8H5cHhzc0K/H/mdwU/qpuESda/5+NIle5i2d2LjK5+AEw/qFjTi0/+ofPcFemXGmnQVgiuioZkyvTCirlqNDug=="],
@@ -3947,6 +3951,8 @@
 
     "next-themes": ["next-themes@0.3.0", "", { "peerDependencies": { "react": "^16.8 || ^17 || ^18", "react-dom": "^16.8 || ^17 || ^18" } }, "sha512-/QHIrsYpd6Kfk7xakK4svpDI5mmXP0gfvCoJdGpZQ2TOrQZmsW0QxjaiLn8wbIKjtm4BTSqLoix4lxYYOnLJ/w=="],
 
+    "nifti-reader-js": ["nifti-reader-js@0.6.9", "", { "dependencies": { "fflate": "*" } }, "sha512-oEC35cuYFR0i+KeXhaK0hJz4oSj511Vo7LmO/6iqbxzwek6XWnBi77VURlk4jsnJ86tlJNpYv6ujmSDpPP46Tw=="],
+
     "no-case": ["no-case@3.0.4", "", { "dependencies": { "lower-case": "^2.0.2", "tslib": "^2.0.3" } }, "sha512-fgAN3jGAh+RoxUGZHTSOLJIqUc2wmoBwGR4tbpNAKmmovFoWq0OdRkb0VkldReO2a2iBT/OEulG9XSUc10r3zg=="],
 
     "node-addon-api": ["node-addon-api@3.2.1", "", {}, "sha512-mmcei9JghVNDYydghQmeDX8KoAm0FAiYyIcUt/N4nhyAipB17pllZQDOJD2fotxABnt4Mdz+dKTO7eftLg4d0A=="],
@@ -5365,6 +5371,8 @@
 
     "@ohif/app/copy-webpack-plugin": ["copy-webpack-plugin@10.2.4", "", { "dependencies": { "fast-glob": "^3.2.7", "glob-parent": "^6.0.1", "globby": "^12.0.2", "normalize-path": "^3.0.0", "schema-utils": "^4.0.0", "serialize-javascript": "^6.0.0" }, "peerDependencies": { "webpack": "^5.1.0" } }, "sha512-xFVltahqlsRcyyJqQbDY6EYTtyQZF9rf+JPjwHObLdPFMEISqkFkr7mFoVOC6BfYS/dNThyoQKvziugm+OnwBg=="],
 
+    "@ohif/extension-default/@cornerstonejs/nifti-volume-loader": ["@cornerstonejs/nifti-volume-loader@4.14.6", "", { "dependencies": { "nifti-reader-js": "0.6.9" }, "peerDependencies": { "@cornerstonejs/core": "4.14.6" } }, "sha512-KmLt3kP3DdwjlKMEFGb2hn0IjMP4P/WzHrkVGFFf2V6V9l3AWlJjwrlV1kFSr9vsQSesBEwWM60j9Km1jGL0qA=="],
+
     "@ohif/extension-default/webpack": ["webpack@5.101.0", "", { "dependencies": { "@types/eslint-scope": "^3.7.7", "@types/estree": "^1.0.8", "@types/json-schema": "^7.0.15", "@webassemblyjs/ast": "^1.14.1", "@webassemblyjs/wasm-edit": "^1.14.1", "@webassemblyjs/wasm-parser": "^1.14.1", "acorn": "^8.15.0", "acorn-import-phases": "^1.0.3", "browserslist": "^4.24.0", "chrome-trace-event": "^1.0.2", "enhanced-resolve": "^5.17.2", "es-module-lexer": "^1.2.1", "eslint-scope": "5.1.1", "events": "^3.2.0", "glob-to-regexp": "^0.4.1", "graceful-fs": "^4.2.11", "json-parse-even-better-errors": "^2.3.1", "loader-runner": "^4.2.0", "mime-types": "^2.1.27", "neo-async": "^2.6.2", "schema-utils": "^4.3.2", "tapable": "^2.1.1", "terser-webpack-plugin": "^5.3.11", "watchpack": "^2.4.1", "webpack-sources": "^3.3.3" }, "bin": { "webpack": "bin/webpack.js" } }, "sha512-B4t+nJqytPeuZlHuIKTbalhljIFXeNRqrUGAQgTGlfOl2lXXKXw+yZu6bicycP+PUlM44CxBjCFD6aciKFT3LQ=="],
 
     "@ohif/extension-measurement-tracking/webpack": ["webpack@5.101.0", "", { "dependencies": { "@types/eslint-scope": "^3.7.7", "@types/estree": "^1.0.8", "@types/json-schema": "^7.0.15", "@webassemblyjs/ast": "^1.14.1", "@webassemblyjs/wasm-edit": "^1.14.1", "@webassemblyjs/wasm-parser": "^1.14.1", "acorn": "^8.15.0", "acorn-import-phases": "^1.0.3", "browserslist": "^4.24.0", "chrome-trace-event": "^1.0.2", "enhanced-resolve": "^5.17.2", "es-module-lexer": "^1.2.1", "eslint-scope": "5.1.1", "events": "^3.2.0", "glob-to-regexp": "^0.4.1", "graceful-fs": "^4.2.11", "json-parse-even-better-errors": "^2.3.1", "loader-runner": "^4.2.0", "mime-types": "^2.1.27", "neo-async": "^2.6.2", "schema-utils": "^4.3.2", "tapable": "^2.1.1", "terser-webpack-plugin": "^5.3.11", "watchpack": "^2.4.1", "webpack-sources": "^3.3.3" }, "bin": { "webpack": "bin/webpack.js" } }, "sha512-B4t+nJqytPeuZlHuIKTbalhljIFXeNRqrUGAQgTGlfOl2lXXKXw+yZu6bicycP+PUlM44CxBjCFD6aciKFT3LQ=="],
diff --git a/extensions/cornerstone/src/init.tsx b/extensions/cornerstone/src/init.tsx
index c8fc0ffade4..0e219c770fa 100644
--- a/extensions/cornerstone/src/init.tsx
+++ b/extensions/cornerstone/src/init.tsx
@@ -9,6 +9,7 @@ import {
   EVENTS,
   metaData,
   volumeLoader,
+  imageLoader,
   imageLoadPoolManager,
   getEnabledElement,
   Settings,
@@ -164,6 +165,9 @@ export default async function init({
     cornerstoneStreamingDynamicImageVolumeLoader
   );
 
+  imageLoader.registerImageLoader('nifti', cornerstoneNiftiImageLoader);
+
+
   // Register strategies using the wrapper
   const imageLoadStrategies = {
     interleaveCenter: interleaveCenterLoader,
diff --git a/extensions/default/package.json b/extensions/default/package.json
index 349323f7571..2b4a2273190 100644
--- a/extensions/default/package.json
+++ b/extensions/default/package.json
@@ -49,6 +49,7 @@
   "dependencies": {
     "@babel/runtime": "7.28.2",
     "@cornerstonejs/calculate-suv": "1.1.0",
+    "@cornerstonejs/nifti-volume-loader": "4.14.6",
     "lodash.get": "4.4.2",
     "lodash.uniqby": "4.7.0"
   }
diff --git a/extensions/default/src/Panels/StudyBrowser/PanelStudyBrowser.tsx b/extensions/default/src/Panels/StudyBrowser/PanelStudyBrowser.tsx
index 052d0fe2839..fc414c79936 100644
--- a/extensions/default/src/Panels/StudyBrowser/PanelStudyBrowser.tsx
+++ b/extensions/default/src/Panels/StudyBrowser/PanelStudyBrowser.tsx
@@ -190,9 +190,14 @@ function PanelStudyBrowser({
     currentDisplaySets.forEach(async dSet => {
       const newImageSrcEntry = {};
       const displaySet = displaySetService.getDisplaySetByUID(dSet.displaySetInstanceUID);
-      const imageIds = dataSource.getImageIdsForDisplaySet(dSet);
 
-      const imageId = getImageIdForThumbnail(displaySet, imageIds);
+      // Wait for imageIds if NIFTI is detected and imageIds are not yet loaded
+      let imageId;
+      if (displaySet.niftiURL && (!imageIds || imageIds.length === 0)) {
+        await displaySet.loadImageIds();
+        imageIds = displaySet.imageIds;
+      }
+      imageId = getImageIdForThumbnail(displaySet, imageIds);
 
       // TODO: Is it okay that imageIds are not returned here for SR displaySets?
       if (displaySet?.unsupported) {
diff --git a/extensions/default/src/getSopClassHandlerModule.js b/extensions/default/src/getSopClassHandlerModule.js
index 902e679a984..4341c70200c 100644
--- a/extensions/default/src/getSopClassHandlerModule.js
+++ b/extensions/default/src/getSopClassHandlerModule.js
@@ -1,9 +1,12 @@
 import { utils, classes } from '@ohif/core';
+import { createNiftiImageIdsAndCacheMetadata } from '@cornerstonejs/nifti-volume-loader';
+
 import i18n from '@ohif/i18n';
 import { id } from './id';
 import getDisplaySetMessages from './getDisplaySetMessages';
 import getDisplaySetsFromUnsupportedSeries from './getDisplaySetsFromUnsupportedSeries';
 import { chartHandler } from './SOPClassHandlers/chartSOPClassHandler';
+import { joinUrl, isAbsolutePathOrUrl } from './utils/urlUtils';
 
 const {
   isImage,
@@ -88,6 +91,37 @@ const makeDisplaySet = (instances, index) => {
   // set appropriate attributes to image set...
   const messages = getDisplaySetMessages(instances, isReconstructable, isDynamicVolume);
 
+  const { niftiPrivateTagName, niftiBaseUrl } = dataSource.getConfig?.() || {};
+  let niftiURL;
+  const niftiPath = instance[niftiPrivateTagName];
+  if (niftiPath) {
+    if (typeof niftiPath === 'string' && !niftiPath.includes('dedupped')) {
+      if (isAbsolutePathOrUrl(niftiPath)) {
+        niftiURL = niftiPath;
+      } else {
+        niftiURL = joinUrl(niftiBaseUrl, niftiPath);
+      }
+    }
+  }
+
+  if (niftiURL) {
+    imageSet.setAttributes({
+      niftiURL,
+      loadImageIds: async () => {
+        try {
+          const imageIds = await createNiftiImageIdsAndCacheMetadata({ url: niftiURL });
+          imageSet.setAttributes({ imageIds });
+          imageSet.setAttributes({
+            numImageFrames: Array.isArray(imageIds) ? imageIds.length : 0,
+          });
+          imageSet.setAttributes({ isReconstructable: true });
+        } catch (e) {
+          console.error('Error loading niftiURL:', e);
+        }
+      },
+    });
+  }
+
   imageSet.setAttributes({
     volumeLoaderSchema,
     displaySetInstanceUID: imageSet.uid, // create a local alias for the imageSet UID
diff --git a/extensions/default/src/utils/urlUtils.js b/extensions/default/src/utils/urlUtils.js
new file mode 100644
index 00000000000..2e5fee9026c
--- /dev/null
+++ b/extensions/default/src/utils/urlUtils.js
@@ -0,0 +1,28 @@
+/**
+ * Checks if a path is an absolute URL (http/https) or absolute path (starts with /)
+ * @param {string} path - The path to check
+ * @returns {boolean} True if the path is absolute
+ */
+export function isAbsolutePathOrUrl(path) {
+  if (!path || typeof path !== 'string') {
+    return false;
+  }
+  return path.startsWith('http://') || path.startsWith('https://') || path.startsWith('/');
+}
+
+/**
+ * Joins a base URL with a relative path
+ * @param {string} baseUrl - The base URL
+ * @param {string} path - The path to join
+ * @returns {string} The joined URL
+ */
+export function joinUrl(baseUrl, path) {
+  if (!baseUrl) return path || '';
+  if (!path) return baseUrl;
+
+  // Remove trailing slash from baseUrl and leading slash from path
+  const base = baseUrl.replace(/\/+$/, '');
+  const relativePath = path.replace(/^\/+/, '');
+
+  return `${base}/${relativePath}`;
+}
diff --git a/package.json b/package.json
index c699ea88994..54cbb8b8e1e 100644
--- a/package.json
+++ b/package.json
@@ -79,6 +79,7 @@
     "link-list": "npm ls --depth=0 --link=true"
   },
   "dependencies": {
+    "@cornerstonejs/nifti-volume-loader": "^4.10.0",
     "execa": "8.0.1"
   },
   "optionalDependencies": {
diff --git a/yarn.lock b/yarn.lock
index 23c59da91dd..43f30ed0dcb 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -1361,6 +1361,20 @@
     "@itk-wasm/morphological-contour-interpolation" "1.1.0"
     itk-wasm "1.0.0-b.165"
 
+"@cornerstonejs/nifti-volume-loader@4.14.6":
+  version "4.14.6"
+  resolved "https://registry.yarnpkg.com/@cornerstonejs/nifti-volume-loader/-/nifti-volume-loader-4.14.6.tgz#8d22858f48d736076bf52c8951b5d9db60c54968"
+  integrity sha512-KmLt3kP3DdwjlKMEFGb2hn0IjMP4P/WzHrkVGFFf2V6V9l3AWlJjwrlV1kFSr9vsQSesBEwWM60j9Km1jGL0qA==
+  dependencies:
+    nifti-reader-js "0.6.9"
+
+"@cornerstonejs/nifti-volume-loader@^4.10.0":
+  version "4.15.0"
+  resolved "https://registry.yarnpkg.com/@cornerstonejs/nifti-volume-loader/-/nifti-volume-loader-4.15.0.tgz#7119c14801a7222507de786475af667e3df9b8fa"
+  integrity sha512-mbpdPB8zzfJ7Gnq0cx3ka1hE9VcWKU/So9OQQqk0HrQl03yB9uIIDu9GnvvNtX+IDZN7jkZWMbYHUJu7I2+BxA==
+  dependencies:
+    nifti-reader-js "0.6.9"
+
 "@cornerstonejs/polymorphic-segmentation@4.14.6":
   version "4.14.6"
   resolved "https://registry.yarnpkg.com/@cornerstonejs/polymorphic-segmentation/-/polymorphic-segmentation-4.14.6.tgz#26154ddd0b1edceca9e6136e264d2d7b34df7c4f"
@@ -8833,6 +8847,11 @@ fetch-blob@^3.1.2, fetch-blob@^3.1.4:
     node-domexception "^1.0.0"
     web-streams-polyfill "^3.0.3"
 
+fflate@*:
+  version "0.8.2"
+  resolved "https://registry.yarnpkg.com/fflate/-/fflate-0.8.2.tgz#fc8631f5347812ad6028bbe4a2308b2792aa1dea"
+  integrity sha512-cPJU47OaAoCbg0pBvzsgpTPhmhqI5eJjh/JIu8tPj5q+T7iLvW/JAYUqmE7KOB4R1ZyEhzBaIQpQpardBF5z8A==
+
 fflate@0.7.3:
   version "0.7.3"
   resolved "https://registry.yarnpkg.com/fflate/-/fflate-0.7.3.tgz#288b034ff0e9c380eaa2feff48c787b8371b7fa5"
@@ -13355,6 +13374,13 @@ next-themes@0.3.0:
   resolved "https://registry.yarnpkg.com/next-themes/-/next-themes-0.3.0.tgz#b4d2a866137a67d42564b07f3a3e720e2ff3871a"
   integrity sha512-/QHIrsYpd6Kfk7xakK4svpDI5mmXP0gfvCoJdGpZQ2TOrQZmsW0QxjaiLn8wbIKjtm4BTSqLoix4lxYYOnLJ/w==
 
+nifti-reader-js@0.6.9:
+  version "0.6.9"
+  resolved "https://registry.yarnpkg.com/nifti-reader-js/-/nifti-reader-js-0.6.9.tgz#737b88eb951c6b98841ce888204a9370214b17e5"
+  integrity sha512-oEC35cuYFR0i+KeXhaK0hJz4oSj511Vo7LmO/6iqbxzwek6XWnBi77VURlk4jsnJ86tlJNpYv6ujmSDpPP46Tw==
+  dependencies:
+    fflate "*"
+
 no-case@^3.0.4:
   version "3.0.4"
   resolved "https://registry.yarnpkg.com/no-case/-/no-case-3.0.4.tgz#d361fd5c9800f558551a8369fc0dcd4662b6124d"