diff --git a/oxart/frontend/aqctl_orca_camera.py b/oxart/frontend/aqctl_orca_camera.py
index 9fd84bb..f6f7a86 100644
--- a/oxart/frontend/aqctl_orca_camera.py
+++ b/oxart/frontend/aqctl_orca_camera.py
@@ -1,17 +1,37 @@
 #!/usr/bin/env python3.5
 import argparse
+from textwrap import dedent
+from typing import Dict, Any, List, Callable
+
+import toml
 import zmq
 import logging
 
 from sipyco.pc_rpc import simple_server_loop
 import sipyco.common_args as sca
-from orca_camera.driver import OrcaFusion
+from orca_camera.driver import OrcaFusion, LibInstance
 
 logger = logging.getLogger(__name__)
 
 
 def get_argparser():
-    parser = argparse.ArgumentParser()
+    parser = argparse.ArgumentParser(
+        epilog=dedent("""\
+            Example configuration file:
+            ```
+            [system1]
+            serial = "S/N: 123456"
+            broadcast_images = true
+            roi = [884, 200, 956, 48]
+            speed = 2
+            
+            [system2]
+            serial = "S/N: 456789"
+            ```
+            
+            The serial must match the string provided by the device exactly.
+        """)
+    )
     sca.simple_network_args(parser, 4000)
     sca.verbosity_args(parser)
     parser.add_argument("--broadcast-images", default=True, action="store_true")
@@ -22,50 +42,119 @@ def get_argparser():
                         default=3,
                         type=int,
                         help="integer value - (0: QUIET, 1: STANDARD, 2: FAST)")
+    parser.add_argument(
+        "--config-file",
+        help="Path to TOML configuration file that allows setting serial, roi, "
+             "speed and broadcast_images for multiple cameras."
+    )
     return parser
 
 
-def create_zmq_server(bind="*", port=5555):
-    context = zmq.Context()
-    socket = context.socket(zmq.PUB)
-    socket.set_hwm(1)
-    socket.bind("tcp://{}:{}".format(bind, port))
-    return socket
-
-
-def main():
-    args = get_argparser().parse_args()
-    sca.init_logger_from_args(args)
-
-    logger.info("Initialising cameras...")
-
-    roi = [int(x) for x in args.roi.split(",")]
-    assert (len(roi) == 4)
-
-    dev = OrcaFusion()
-    dev.open(camera_index=0, framebuffer_len=1000)
-    dev.set_subarray(*roi)
-    dev.set_readout_speed(args.speed)
+def lazy_zmq_server(bind="*", port=5555):
+    socket = None
+
+    def create_zmq_server():
+        nonlocal socket
+        if socket is None:
+            context = zmq.Context()
+            socket = context.socket(zmq.PUB)
+            socket.set_hwm(1)
+            socket.bind("tcp://{}:{}".format(bind, port))
+        return socket
+
+    return create_zmq_server
+
+
+def init_dev(
+        name: str,
+        args: Dict[str, Any],
+        devs: List[OrcaFusion],
+        create_zmq_server: Callable[[], Any],
+) -> OrcaFusion:
+
+    if args["serial"] is None and len(devs) != 1:
+        raise ValueError(
+            f"Multiple cameras present but no serial set for {name}. Camera "
+            f"serials present: {', '.join(repr(dev.get_serial()) for dev in devs)}"
+        )
+    elif args["serial"] is None and len(devs) == 1:
+        dev = devs[0]
+    else:
+        for idx, dev in enumerate(devs):
+            if dev.get_serial() == args["serial"]:
+                break
+        else:
+            raise ValueError(
+                f"Unable to find camera with serial number {args['serial']} for "
+                f"{name}. Camera serials present: "
+                f"{', '.join(repr(dev.get_serial()) for dev in devs)}"
+            )
+        # Remove the matched device so that we don't reference the same device
+        # twice with different arguments
+        del devs[idx]
+
+    if "roi" in args:
+        dev.set_subarray(*args["roi"])
+    if "speed" in args:
+        dev.set_readout_speed(args["speed"])
     dev.start_capture()
 
-    if args.broadcast_images:
-        socket = create_zmq_server(args.zmq_bind, args.zmq_port)
+    if args.get("broadcast_images", False):
+        socket = create_zmq_server()
 
         def frame_callback(im):
             # We send a multi-part message with first part the serial number
             # this allows the subscriber to filter out unwanted images
-            socket.send_string(str(0), flags=zmq.SNDMORE)
+            socket.send_string(dev.get_serial(), flags=zmq.SNDMORE)
             socket.send_pyobj(im.transpose())
 
         dev.register_callback(frame_callback)
 
+    return dev
+
+
+def main():
+    args = get_argparser().parse_args()
+    sca.init_logger_from_args(args)
+
+    logger.info("Initialising cameras...")
+
+    if args.config_file:
+        config = toml.load(args.config_file)
+    else:
+        roi = [int(x) for x in args.roi.split(",")]
+        if len(roi) != 4:
+            raise ValueError("--roi should be 4 comma separated numbers")
+
+        config = {
+            "camera": {
+                "serial": None,
+                "broadcast_images": args.broadcast_images,
+                "roi": roi,
+                "speed": args.speed,
+            }
+        }
+
+    devs = [
+        OrcaFusion(idx, framebuffer_len=1000)
+        for idx in range(LibInstance.get().num_dev)
+    ]
+    all_devs = devs.copy()
+    create_zmq_server = lazy_zmq_server(args.zmq_bind, args.zmq_port)
+
+    servers = {
+        name: init_dev(name, args, devs, create_zmq_server)
+        for name, args in config.items()
+    }
+
     try:
-        simple_server_loop({"camera": dev}, args.bind, args.port)
+        simple_server_loop(servers, args.bind, args.port)
     except KeyboardInterrupt:
         pass
     finally:
         logger.info("Shutting down camera ...")
-        dev.close()
+        for dev in all_devs:
+            dev.close()
 
 
 if __name__ == "__main__":
diff --git a/setup.py b/setup.py
index c5d1806..d8b6541 100644
--- a/setup.py
+++ b/setup.py
@@ -43,7 +43,12 @@
     author="Oxford Ion Trap Quantum Computing Group",
     packages=find_packages(),
     entry_points={"console_scripts": scripts},
-    install_requires=["sipyco", "appdirs"],
+    install_requires=[
+        "sipyco",
+        "appdirs",
+        "toml",
+        "pyzmq",
+    ],
     # zip_safe=False apparently improves compatibility for namespace packages:
     # https://github.com/pypa/sample-namespace-packages/issues/6
     zip_safe=False,