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1 | | -Tabby2 is a web application providing predictions of future TB |
2 | | -epidemiology in the United States under a range of different assumptions |
3 | | -and policy scenarios. Users can select a health outcome and |
4 | | -subpopulation of interest, then select one or multiple scenarios to |
5 | | -compare. Results are displayed graphically, and following inputs from |
6 | | -the user the graphs update automatically to reflect the new selections. |
7 | | -Visualizations can be downloaded in various formats, and the estimates |
8 | | -underlying the graphs can also be downloaded in tabular format. |
| 1 | +Tabby2 is a web application that provides projections of future tuberculosis |
| 2 | +(TB) epidemiology in the United States under a range of TB and LTBI testing and |
| 3 | +treatment scenarios that can be chosen by the user. The application includes |
| 4 | +several predefined scenarios, which explore changes in the care cascades for TB |
| 5 | +disease and latent TB infection (LTBI). The application also allows users to |
| 6 | +define new scenarios, which can project the impact of greater targeted testing |
| 7 | +and treatment of high-risk populations, or changes to the performance of |
| 8 | +current TB control programs. After specifying scenarios, users can select a |
| 9 | +health outcome and subpopulation of interest, and then view results of one or |
| 10 | +more of the scenarios they have specified. Results are displayed graphically, |
| 11 | +and these graphs can be adjusted based on user input to include additional |
| 12 | +results or focus on particular population subgroups. Visualizations can be |
| 13 | +downloaded in various formats, and the estimates underlying the graphs can also |
| 14 | +be downloaded in tabular format. |
9 | 15 |
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10 | | -The estimates shown by Tabby2 are based on a transmission-dynamic model |
11 | | -of TB epidemiology in the US, incorporating TB transmission and natural |
12 | | -history; TB drug resistance patterns; prior and future TB prevention and |
13 | | -control; the impact of HIV on TB; heterogeneity in TB risks among |
14 | | -US-born and foreign-born populations; and age-based differences in |
15 | | -disease mechanisms and risk factor prevalence. Detailed methods |
16 | | -(analytic methods, scenario and outcome definitions) and main results |
17 | | -for this analysis are described in detail in "Prospects for tuberculosis |
18 | | -elimination in the United States: results of a transmission dynamic |
19 | | -model". |
| 16 | +The estimates shown by Tabby2 are based on a mathematical model of TB |
| 17 | +epidemiology in the United States, which incorporates TB transmission and |
| 18 | +natural history; prior and future TB prevention and control; heterogeneity in |
| 19 | +TB risks among U.S.-born and non-U.S.-born populations; and age-based |
| 20 | +differences in disease mechanisms and risk factor prevalence. This model has |
| 21 | +been fit to local data from each of the following high TB incidence states: |
| 22 | +California, Florida, Georgia, Illinois, Massachusetts, New Jersey, New York, |
| 23 | +Pennsylvania, Texas, Virginia, and Washington. The model has also been fit to |
| 24 | +aggregate data for the United States to allow national-level analyses. These |
| 25 | +analyses expand on an earlier study on future TB epidemiology in the United |
| 26 | +States (Menzies et al 2018. “Prospects for tuberculosis elimination in the |
| 27 | +United States: results of a transmission dynamic model” Am J Epid |
| 28 | +187(9):2011-2020) (<https://academic.oup.com/aje/article/187/9/2011/4995883>)). |
| 29 | + |
| 30 | +This research was funded by the CDC, National Center for HIV, Viral Hepatitis, |
| 31 | +STD, and TB Prevention Epidemiologic and Economic Modeling Agreement (NEEMA, \# |
| 32 | +5U38PS004644-01). |
20 | 33 |
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21 | | -This web tool was funded by the CDC, National Center for |
22 | | -HIV, Viral Hepatitis, STD, and TB Prevention Epidemiologic and Economic |
23 | | -Modeling Agreement (NEEMA, \# 5U38PS004644-01). |
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