diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 615cd3e8..b3d9264b 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -456,6 +456,27 @@ jobs:
         run: tox -e py
         working-directory: ./bindings/python
 
+  build-pyodide:
+    name: Build PyOdide wheel
+    runs-on: ubuntu-22.04
+    steps:
+      - uses: actions/checkout@v4
+      - uses: dtolnay/rust-toolchain@nightly
+        with:
+          toolchain: nightly
+          targets: wasm32-unknown-emscripten
+      - uses: actions/setup-python@v5
+        with:
+          python-version: 3.12
+      - run: |
+          pip install pyodide-build>=0.28.0
+          echo EMSCRIPTEN_VERSION=$(pyodide config get emscripten_version) >> $GITHUB_ENV
+      - uses: mymindstorm/setup-emsdk@v14
+        with:
+          version: ${{ env.EMSCRIPTEN_VERSION }}
+      - run: pyodide build
+        working-directory: ./bindings/python
+
   test-ruby:
     strategy:
       fail-fast: false
diff --git a/bindings/python/CHANGELOG.md b/bindings/python/CHANGELOG.md
index 86011515..2892442c 100644
--- a/bindings/python/CHANGELOG.md
+++ b/bindings/python/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 ## [Unreleased]
 
+### Added
+
+- Support & build for PyOdide. [#411](https://github.com/Stranger6667/css-inline/pull/411)
+
 ### Changed
 
 - Bump MSRV to `1.71.1`.
diff --git a/bindings/python/Cargo.toml b/bindings/python/Cargo.toml
index e286df51..8649e06d 100644
--- a/bindings/python/Cargo.toml
+++ b/bindings/python/Cargo.toml
@@ -19,7 +19,13 @@ pyo3-built = "0.5"
 rayon = "1"
 url = "2"
 
-[dependencies.css-inline]
+[target.'cfg(target_arch = "wasm32")'.dependencies.css-inline]
+path = "../../css-inline"
+version = "*"
+default-features = false
+features = ["stylesheet-cache"]
+
+[target.'cfg(not(target_arch = "wasm32"))'.dependencies.css-inline]
 path = "../../css-inline"
 version = "*"
 default-features = false
diff --git a/bindings/python/README.md b/bindings/python/README.md
index d185df37..d6cc3539 100644
--- a/bindings/python/README.md
+++ b/bindings/python/README.md
@@ -42,7 +42,7 @@ into:
 - Resolves external stylesheets (including local files)
 - Optionally caches external stylesheets
 - Can process multiple documents in parallel
-- Works on Linux, Windows, and macOS
+- Works on Linux, Windows, macOS and in the browser via PyOdide
 - Supports HTML5 & CSS3
 - Tested on CPython 3.7, 3.8, 3.9, 3.10, 3.11, 3.12 and PyPy 3.7, 3.8, 3.9, 3.10.
 
diff --git a/bindings/python/src/lib.rs b/bindings/python/src/lib.rs
index 743dac5b..e2430778 100644
--- a/bindings/python/src/lib.rs
+++ b/bindings/python/src/lib.rs
@@ -41,6 +41,7 @@ impl From<InlineErrorWrapper> for PyErr {
     fn from(error: InlineErrorWrapper) -> Self {
         match error.0 {
             rust_inline::InlineError::IO(error) => InlineError::new_err(error.to_string()),
+            #[cfg(not(target_arch = "wasm32"))]
             rust_inline::InlineError::Network { .. } => InlineError::new_err(error.0.to_string()),
             rust_inline::InlineError::ParseError(message) => {
                 InlineError::new_err(message.to_string())