diff --git a/src/agentscope_runtime/engine/app/agent_app.py b/src/agentscope_runtime/engine/app/agent_app.py
index 59caf0077..c9ae336ac 100644
--- a/src/agentscope_runtime/engine/app/agent_app.py
+++ b/src/agentscope_runtime/engine/app/agent_app.py
@@ -878,7 +878,14 @@ def _apply_runtime_configs(self, kwargs: dict):
             custom_endpoints = kwargs.pop("custom_endpoints")
             self.restore_custom_endpoints(custom_endpoints)
 
-    def run(self, host=HOST, port=PORT, web_ui=False, **kwargs):
+    def run(
+        self,
+        host=HOST,
+        port=PORT,
+        web_ui=False,
+        timeout_keep_alive=120,
+        **kwargs,
+    ):
         """Launch the application server and optional Web UI."""
 
         self._apply_runtime_configs(kwargs)
@@ -913,6 +920,7 @@ def run(self, host=HOST, port=PORT, web_ui=False, **kwargs):
                         port=port,
                         log_level="info",
                         access_log=True,
+                        timeout_keep_alive=timeout_keep_alive,
                     )
             else:
                 uvicorn.run(
@@ -921,6 +929,7 @@ def run(self, host=HOST, port=PORT, web_ui=False, **kwargs):
                     port=port,
                     log_level="info",
                     access_log=True,
+                    timeout_keep_alive=timeout_keep_alive,
                 )
 
         except KeyboardInterrupt:
diff --git a/src/agentscope_runtime/sandbox/manager/server/app.py b/src/agentscope_runtime/sandbox/manager/server/app.py
index 06f232066..db57c6c8c 100644
--- a/src/agentscope_runtime/sandbox/manager/server/app.py
+++ b/src/agentscope_runtime/sandbox/manager/server/app.py
@@ -440,6 +440,7 @@ def main():
         port=settings.PORT,
         workers=settings.WORKERS,
         reload=settings.DEBUG,
+        timeout_keep_alive=settings.TIMEOUT_KEEP_ALIVE,
     )
 
 
diff --git a/src/agentscope_runtime/sandbox/manager/server/config.py b/src/agentscope_runtime/sandbox/manager/server/config.py
index 003f498cb..218ae163f 100644
--- a/src/agentscope_runtime/sandbox/manager/server/config.py
+++ b/src/agentscope_runtime/sandbox/manager/server/config.py
@@ -16,6 +16,7 @@ class Settings(BaseSettings):
     PORT: int = 8000
     WORKERS: int = 1
     DEBUG: bool = False
+    TIMEOUT_KEEP_ALIVE: int = 120
     BEARER_TOKEN: Optional[str] = None
 
     # Runtime Manager settings