NTR: p24 cargo receptor complex

[dragon-ai-agent]

Shadow ticket of geneontology/go-ontology#31295

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Please provide as much information as you can:

• Suggested term label:
  p24 cargo receptor complex (Unfortunately this is the only name I can find)

• Definition (free text)

A cargo receptor complex localized to the Endoplasmic Reticulum (ER) exit sites, where it helps to select cargo for packaging into COPII vesicles.

• Reference, in format PMID:#######

PMID:32456004
PMID:34647572
PMID:27569046

• Gene product name and ID to be annotated to this term

Systematic ID Gene name pombe Product description Budding yeast orthologs Human orthologs
SPBC16E9.09c erp5 COPII vesicle coat component Erp5/Erp6/Erp1 ERP1,ERP5,ERP6 TMED4,TMED9
SPCC24B10.17 emp24 COPII-coated vesicle component Emp24 EMP24 TMED2
SPAC17A5.08 erp2 COPII-coated vesicle component Erp2/3/4 ERP2,ERP3,ERP4 TMED3
SPAC23H4.03c erv25 COPII-coated vesicle component Erv25 ERV25 TMED10

• Parent term(s)

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Synonyms (please specify, EXACT, BROAD, NARROW or RELATED)

• Cross-references

• For enzymes, please provide RHEA and/or EC numbers.

• Can also provide MetaCyc, KEGG, Wikipedia, and other links.

• Any other information

[cmungall]

@dragon-ai-agent please implement

[dragon-ai-agent]

🤖 Working on it...

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[dragon-ai-agent]

I've implemented the new p24 cargo receptor complex term as requested.

New Term Created

GO:7770035 - p24 cargo receptor complex

Definition: A hetero-oligomeric protein complex composed of members from four p24 subfamilies (alpha, beta, gamma, and delta) that localizes to endoplasmic reticulum exit sites and cycles between the endoplasmic reticulum and Golgi apparatus. The complex functions as a cargo receptor for selective protein transport, particularly for GPI-anchored proteins, and helps select cargo for packaging into COPII vesicles.

Parent: GO:0062137 (cargo receptor complex)

Relationship: part_of GO:0070971 (endoplasmic reticulum exit site)

Synonyms:

• "Emp24 complex" (NARROW)
• "p24 hetero-oligomeric complex" (EXACT)
• "p24 protein complex" (EXACT)

References: PMID:27569046, PMID:32456004, PMID:34647572

Pull Request

See PR #18 for the implementation.

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🤖 Generated by @dragon-ai-agent

• Model: claude-opus-4-5-20251101
• Agent harness: claude-code
• Triggered by: @cmungall
• Run: View workflow run

[cmungall]

@dragon-ai-agent please do this again. I closed the first PR as it was accidentally using old agent instructions

[dragon-ai-agent]

🤖 Working on it...

Follow along: View workflow run

— @dragon-ai-agent

[dragon-ai-agent]

I've re-implemented the p24 cargo receptor complex term as requested.

New Term Created

GO:7770035 - p24 cargo receptor complex

A hetero-oligomeric cargo receptor complex composed of p24 family proteins from four subfamilies (alpha, beta, gamma, delta) that localizes to ER exit sites. The complex functions in COPII-mediated vesicular transport, particularly for GPI-anchored proteins.

Parent: GO:0062137 (cargo receptor complex)
Location: part_of GO:0070971 (endoplasmic reticulum exit site)

Definition references:

• PMID:32456004 - Dual roles of p24 complex in cargo selectivity
• PMID:34647572 - Differential use of p24 family members for GPI-AP and Wnt1 transport
• PMID:27569046 - GOLD domain structure and p24 complex formation

Research Summary

The p24 proteins form higher-order oligomeric structures (likely octameric) at ER exit sites where they:

1. Act as specific cargo receptors for GPI-anchored proteins
2. Prevent non-selective bulk flow of secretory cargo
3. Interact with Tango1 to maintain ERES stability
4. Cycle between ER and Golgi via COPII/COPI vesicles

Pull Request

See PR #27 for the implementation details.

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🤖 Generated by @dragon-ai-agent

• Model: claude-opus-4-5-20251101
• Agent harness: claude-code
• Triggered by: @cmungall
• Run: View workflow run