NTR: negative regulation of carbon utilization

[dragon-ai-agent]

Shadow ticket of geneontology/go-ontology#31261

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Please provide as much information as you can:

• Suggested term label:

negative regulation of carbon utilization

• Definition (free text)

standard def

• Reference, in format PMID:#######

PMID:34028542
https://www.pombase.org/reference/PMID:34028542

• Gene product name and ID to be annotated to this term

aly3
https://www.pombase.org/reference/PMID:34028542

• Parent term(s)

GO:0043609 regulation of carbon utilization

[cmungall]

@dragon-ai-agent please analyze and implement

[dragon-ai-agent]

🤖 Working on it...

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[dragon-ai-agent]

✅ Implementation Complete

I've created a new GO term for "negative regulation of carbon utilization" following the standard negative regulation design pattern.

New Term: GO:1990987

Property	Value
ID	GO:1990987
Name	negative regulation of carbon utilization
Definition	Any process that stops, prevents, or reduces the frequency, rate or extent of carbon utilization.
Parent	GO:0043609 (regulation of carbon utilization) via logical definition
Regulates	GO:0015976 (carbon utilization)

Design Pattern Compliance

The term follows the negative_regulation.yaml design pattern with:

• Standard definition format
• Logical definition using negatively_regulates
• Standard synonyms (down regulation, downregulation, inhibition)

Reference Verification

PMID:34028542 is valid and relevant - it describes how aly3 (the gene mentioned in the request) regulates carbon utilization in S. pombe by controlling glucose transporter localization.

Pull Request

PR #16: #16

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🤖 Generated by @dragon-ai-agent

• Model: claude-opus-4-5-20251101
• Agent harness: claude-code
• Triggered by: @cmungall
• Run: View workflow run

[cmungall]

@dragon-ai-agent please do this again. I closed the first PR as it was accidentally using old agent instructions

[dragon-ai-agent]

🤖 Working on it...

Follow along: View workflow run

— @dragon-ai-agent

[dragon-ai-agent]

Implementation Complete

I've created the new term GO:7770035 "negative regulation of carbon utilization" following the standard negative regulation design pattern.

New Term Summary

Property	Value
ID	GO:7770035
Name	negative regulation of carbon utilization
Definition	Any process that stops, prevents, or reduces the frequency, rate or extent of carbon utilization.
Parent	GO:0043609 (regulation of carbon utilization) - inferred via logical definition
Regulates	GO:0015976 (carbon utilization)

Reference Validation

PMID:34028542 describes the aly3 gene encoding an α-arrestin protein in S. pombe that negatively regulates carbon utilization by:

• Promoting ubiquitylation of the Ght5 glucose transporter
• Causing vacuolar degradation of glucose transporters
• Reducing glucose uptake capacity

This supports annotating aly3 with the new term.

Pull Request

PR #24: #24

All validation checks passed.

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🤖 Generated by @dragon-ai-agent

• Model: claude-opus-4-5-20251101
• Agent harness: claude-code
• Triggered by: @cmungall
• Run: View workflow run