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update wp and resource descriptions
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src/pages/about/work-packages.astro

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@@ -30,15 +30,15 @@ const workPackages = [
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{
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id: "WP1",
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title: "Data Collection and Curation",
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goal: "Gathering and preparing the essential patient data needed to build, train, and test the digital twins.",
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goal: "Gathering and preparing the patient data needed to build, train, and test the digital twins.",
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purpose: [
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"Bring together existing (retrospective) data from large international, national, and local patient databases and registries for Pulmonary Arterial Hypertension, alongside general population data (e.g., UK Biobank).",
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"Run a dedicated prospective clinical study to collect new, detailed data from PAH patients over time, using standard care methods, intensive hospital/remote monitoring (e.g. wearables, MRI), and even embedded monitors.",
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"Bring together existing data from large international, national, and local patient databases and registries for Pulmonary Hypertension, alongside general population data (e.g., UK Biobank).",
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"Run a prospective clinical study to collect new, detailed data from PAH patients over time, using standard care methods, hospital based investigation and remote monitoring.",
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"This real-world data collection is vital for driving and evaluating the DT demonstrator.",
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],
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leads: ["Alex Rothman", "Martin Wilkins"],
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currentFocus:
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"Establishing data sharing agreements and initiating prospective data collection protocols.",
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// currentFocus:
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// "Establishing data sharing agreements and initiating prospective data collection protocols.",
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},
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{
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id: "WP2",
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],
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leads: ["Richard Wilkinson"],
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currentFocus:
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"Developing baseline cardiovascular models and initial calibration algorithms using synthetic data.",
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" Using linear emulators, which enable real-time calibration via a closed form expression, and extending this to a linear state-space model to enable parameters to vary through time.",
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},
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{
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id: "WP4",
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"Reduce the cost and improve the accuracy of calibrating and forecasting DTs by exploiting collective information within the network.",
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],
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leads: ["Elizabeth Cross", "Keith Worden"],
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currentFocus:
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"Researching methodologies for federated learning and defining similarity metrics for patient cohorts.",
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// currentFocus:
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// "Researching methodologies for federated learning and defining similarity metrics for patient cohorts.",
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},
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{
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id: "WP6",

src/pages/resources/modularcirc.astro

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<div class="mx-auto">
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<p class="mb-4 text-lg leading-relaxed text-slate-600">
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ModularCirc is a software toolkit designed to help scientists
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and engineers create computer simulations of the heart and
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circulatory system. Think of it as a set of digital building
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blocks that represent different parts of our cardiovascular
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system, like heart chambers (e.g., atria and ventricles), valves
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(which control blood flow direction), and various blood vessels
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(like arteries and veins).
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ModularCirc is a Python-based toolkit designed to simulate how
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blood flows through the body. It focuses on simplified,
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mathematical representations of the cardiovascular system—known
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as lumped parameter models. These models approximate key
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physiological quantities, such as blood pressure or heart
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chamber volume, using single values that represent entire
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regions or organs. This approach makes simulations faster and
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easier to work with while still capturing important dynamics.
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</p>
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<p class="mb-4 text-lg leading-relaxed text-slate-600">
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The "modular" part of its name is key. Instead of building a
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highly detailed 3D anatomical replica, ModularCirc uses a
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simplified but effective approach. It treats each component as a
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distinct module with specific functions and properties (e.g.,
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how elastic a heart chamber is, or how much resistance a vessel
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offers to blood flow). Researchers can then connect these
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modules, much like an electrical circuit, to build a complete,
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functional model of how blood circulates throughout the body.
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</p>
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<p class="mb-4 text-lg leading-relaxed text-slate-600">
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This flexibility is powerful. Scientists can easily swap modules
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or change their characteristics to simulate different scenarios
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– for example, to study the impact of a leaky heart valve, the
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stiffening of arteries, or the effect of a potential new
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treatment. By running these simulations, they can gain insights
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into how the cardiovascular system works in health and disease,
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predict changes, and explore "what-if" questions without needing
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invasive procedures. This makes ModularCirc a valuable tool for
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those working towards creating "digital twins" of the heart –
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virtual replicas that can help us better understand, predict,
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and manage cardiovascular health.
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The library is built to support users with different levels of
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expertise. At the simplest level, ModularCirc provides
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ready-made models that can be loaded and explored without
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writing much code—ideal for quick testing and learning. For
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those who want more control, it offers a set of building blocks
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(like simplified arteries or heart chambers) that can be
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connected to form custom systems. And for advanced users,
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ModularCirc makes it possible to create entirely new components
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from scratch, offering full flexibility to define how each part
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behaves. This layered design makes it a powerful and adaptable
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tool for cardiovascular research and education.
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</p>
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<h2 class="mb-4 text-2xl font-semibold text-slate-700">

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