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Sequence UNET is a fully convolutional neural network variant effect predictor, able to predict the pathogenicity of protein coding variants and the frequency they occur across large multiple sequence alignments.
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A description and discussion of the model is available on bioRxiv [(Dunham et al. 2022)](https://www.biorxiv.org/content/10.1101/2022.05.23.493038).
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A description and discussion of the model is available in [Dunham et al. 2023](https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-02948-3).
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It uses a U-shaped architecture inspired by the U-NET medical image segmentation network [(Ronneberger et al. 2015)](http://arxiv.org/abs/1505.04597), with an optional Graph CNN section to incorporate information from protein structure:
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