diff --git a/flink-doris-connector/flink-doris-connector-flink1/src/main/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSync.java b/flink-doris-connector/flink-doris-connector-flink1/src/main/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSync.java
index 9fdfdcaed..df19ce0d6 100644
--- a/flink-doris-connector/flink-doris-connector-flink1/src/main/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSync.java
+++ b/flink-doris-connector/flink-doris-connector-flink1/src/main/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSync.java
@@ -49,9 +49,11 @@
 import java.sql.SQLException;
 import java.util.ArrayList;
 import java.util.HashMap;
+import java.util.HashSet;
 import java.util.List;
 import java.util.Map;
 import java.util.Properties;
+import java.util.Set;
 import java.util.regex.Matcher;
 import java.util.regex.Pattern;
 
@@ -100,6 +102,8 @@ public Connection getConnection() throws SQLException {
     @Override
     public List<SourceSchema> getSchemaList() throws Exception {
         String databaseName = config.get(MySqlSourceOptions.DATABASE_NAME);
+        Set<String> chunkKeyTables = getChunkKeyTables();
+        List<String> skippedNoPrimaryKeyTables = new ArrayList<>();
 
         List<SourceSchema> schemaList = new ArrayList<>();
         try (Connection conn = getConnection()) {
@@ -120,6 +124,14 @@ public List<SourceSchema> getSchemaList() throws Exception {
                                 SourceSchema sourceSchema =
                                         new MysqlSchema(
                                                 metaData, tableCatalog, tableName, tableComment);
+                                if (shouldSkipTableWithoutPrimaryKey(
+                                        tableCatalog,
+                                        tableName,
+                                        sourceSchema.primaryKeys.isEmpty(),
+                                        chunkKeyTables)) {
+                                    skippedNoPrimaryKeyTables.add(tableCatalog + "." + tableName);
+                                    continue;
+                                }
                                 sourceSchema.setModel(
                                         !sourceSchema.primaryKeys.isEmpty()
                                                 ? DataModel.UNIQUE
@@ -131,9 +143,54 @@ public List<SourceSchema> getSchemaList() throws Exception {
                 }
             }
         }
+
+        if (!skippedNoPrimaryKeyTables.isEmpty()) {
+            LOG.warn(
+                    "Skipping MySQL tables without primary key in incremental snapshot mode (no chunk key configured): {}. "
+                            + "Configure '{}' for these tables if snapshot sync is required.",
+                    skippedNoPrimaryKeyTables,
+                    MySqlSourceOptions.SCAN_INCREMENTAL_SNAPSHOT_CHUNK_KEY_COLUMN.key());
+        }
+        if (schemaList.isEmpty() && !skippedNoPrimaryKeyTables.isEmpty()) {
+            throw new IllegalStateException(
+                    String.format(
+                            "No MySQL tables left to synchronize: all matched tables are without primary key and no chunk key is configured in initial snapshot mode. "
+                                    + "Skipped tables: %s",
+                            skippedNoPrimaryKeyTables));
+        }
         return schemaList;
     }
 
+    boolean shouldSkipTableWithoutPrimaryKey(
+            String databaseName,
+            String tableName,
+            boolean hasNoPrimaryKey,
+            Set<String> chunkKeyTables) {
+        if (!hasNoPrimaryKey) {
+            return false;
+        }
+        if (!isInitialSnapshotStartup()) {
+            return false;
+        }
+        return !chunkKeyTables.contains(databaseName + "." + tableName);
+    }
+
+    private boolean isInitialSnapshotStartup() {
+        String startupMode = config.get(MySqlSourceOptions.SCAN_STARTUP_MODE);
+        if (StringUtils.isNullOrWhitespaceOnly(startupMode)) {
+            return true;
+        }
+        return DatabaseSyncConfig.SCAN_STARTUP_MODE_VALUE_INITIAL.equalsIgnoreCase(startupMode);
+    }
+
+    private Set<String> getChunkKeyTables() {
+        Set<String> tables = new HashSet<>();
+        for (ObjectPath objectPath : getChunkColumnMap().keySet()) {
+            tables.add(objectPath.getDatabaseName() + "." + objectPath.getObjectName());
+        }
+        return tables;
+    }
+
     @Override
     public DataStreamSource<String> buildCdcSource(StreamExecutionEnvironment env) {
         MySqlSourceBuilder<String> sourceBuilder = MySqlSource.builder();
diff --git a/flink-doris-connector/flink-doris-connector-flink1/src/test/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSyncTest.java b/flink-doris-connector/flink-doris-connector-flink1/src/test/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSyncTest.java
new file mode 100644
index 000000000..95d248a73
--- /dev/null
+++ b/flink-doris-connector/flink-doris-connector-flink1/src/test/java/org/apache/doris/flink/tools/cdc/mysql/MysqlDatabaseSyncTest.java
@@ -0,0 +1,76 @@
+// Licensed to the Apache Software Foundation (ASF) under one
+// or more contributor license agreements.  See the NOTICE file
+// distributed with this work for additional information
+// regarding copyright ownership.  The ASF licenses this file
+// to you under the Apache License, Version 2.0 (the
+// "License"); you may not use this file except in compliance
+// with the License.  You may obtain a copy of the License at
+//
+//   http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing,
+// software distributed under the License is distributed on an
+// "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+// KIND, either express or implied.  See the License for the
+// specific language governing permissions and limitations
+// under the License.
+
+package org.apache.doris.flink.tools.cdc.mysql;
+
+import org.apache.flink.cdc.connectors.mysql.source.config.MySqlSourceOptions;
+import org.apache.flink.configuration.Configuration;
+
+import org.junit.Assert;
+import org.junit.Test;
+
+import java.util.Collections;
+import java.util.HashSet;
+import java.util.Set;
+
+public class MysqlDatabaseSyncTest {
+
+    @Test
+    public void testSkipTableWithoutPrimaryKeyInInitialSnapshot() throws Exception {
+        MysqlDatabaseSync sync = new MysqlDatabaseSync();
+        Configuration config = new Configuration();
+        config.setString(MySqlSourceOptions.SCAN_STARTUP_MODE.key(), "initial");
+        sync.setConfig(config);
+
+        boolean shouldSkip =
+                sync.shouldSkipTableWithoutPrimaryKey(
+                        "test_db", "no_pk_table", true, Collections.emptySet());
+
+        Assert.assertTrue(shouldSkip);
+    }
+
+    @Test
+    public void testDoNotSkipTableWithoutPrimaryKeyWhenChunkKeyConfigured() throws Exception {
+        MysqlDatabaseSync sync = new MysqlDatabaseSync();
+        Configuration config = new Configuration();
+        config.setString(MySqlSourceOptions.SCAN_STARTUP_MODE.key(), "initial");
+        sync.setConfig(config);
+
+        Set<String> chunkKeyTables = new HashSet<>();
+        chunkKeyTables.add("test_db.no_pk_table");
+
+        boolean shouldSkip =
+                sync.shouldSkipTableWithoutPrimaryKey(
+                        "test_db", "no_pk_table", true, chunkKeyTables);
+
+        Assert.assertFalse(shouldSkip);
+    }
+
+    @Test
+    public void testDoNotSkipTableWithoutPrimaryKeyForNonInitialStartup() throws Exception {
+        MysqlDatabaseSync sync = new MysqlDatabaseSync();
+        Configuration config = new Configuration();
+        config.setString(MySqlSourceOptions.SCAN_STARTUP_MODE.key(), "latest-offset");
+        sync.setConfig(config);
+
+        boolean shouldSkip =
+                sync.shouldSkipTableWithoutPrimaryKey(
+                        "test_db", "no_pk_table", true, Collections.emptySet());
+
+        Assert.assertFalse(shouldSkip);
+    }
+}