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Update Post “2026-03-gnomad-v4-1-1”
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content/posts/2026-03-gnomad-v4-1-1.md

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@@ -58,8 +58,6 @@ v4:
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![Screenshot of 11-65780304-CT-C Ensembl VEP consequences in gnomAD v4](../images/v4_lc_plof_vep.png)
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![Screenshot of variant 11-65547775-CT-C on gene page in gnomAD v2](../images/v2_hc_plof.png)
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![Screenshot of gene BAHCC1 with new low coverage flag](../images/low_cov_flag.png)
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Low mappability flag:
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![Screenshot of gene ARHGEF5 with new low mappability flag](../images/low_mappability_flag.png)
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The v4.1.1 gene constraint metrics are displayed on the gene pages (e.g., *[CHD7](https://gnomad.broadinstitute.org/gene/ENSG00000171316?dataset=gnomad_r4)*). The metrics and the calculated mutation rates underlying our expected variant counts are also available for [download](https://gnomad.broadinstitute.org/data#v4-constraint).
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As before, our constraint calculations are made using unique single nucleotide variants with a minor allele frequency < 0.1% (see more information in our [FAQ](https://gnomad.broadinstitute.org/help/constraint)). Note that any users interested in identifying the set of variants included in the constraint calculations can do so using our new utility repository, the [gnomAD toolbox](https://gnomad.broadinstitute.org/news/2025-01-gnomad-toolbox/).
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As before, our constraint calculations are made using unique single nucleotide variants with a minor allele frequency < 0.1% (see more information in our [FAQ](https://gnomad.broadinstitute.org/help/constraint)).
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### End notes – still a work in progress!
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