diff --git a/browser/help/topics/vep.md b/browser/help/topics/vep.md index 8d07bc5df..17966f1a0 100644 --- a/browser/help/topics/vep.md +++ b/browser/help/topics/vep.md @@ -3,11 +3,13 @@ id: vep title: 'Annotations in gnomAD' --- -### gnomAD v4.1 +### gnomAD v4.1.1 -#### VEP +#### Ensembl VEP -Variants in the browser (and all current VCFs available for download) were annotated using VEP version 105 using GENCODE v39 on GRCh38, with the [LOFTEE](https://github.com/konradjk/loftee) (Loss-Of-Function Transcript Effect Estimator) plugin. +Variants in the browser (and all current VCFs available for download) were annotated using Ensembl VEP version 105 using GENCODE v39 on GRCh38, with the [LOFTEE](https://github.com/konradjk/loftee) (Loss-Of-Function Transcript Effect Estimator) plugin. + +Note that only variants in the gene [RNU4ATAC](https://gnomad.broadinstitute.org/gene/ENSG00000264229?dataset=gnomad_r4) were annotated using Ensembl VEP version 115 (GENCODE v49 on GRCh38) on the browser. Ensembl VEP version 115 annotations for other [GENCODE basic transcripts](https://www.gencodegenes.org/pages/faq.html) are available in our [downloadable Hail Tables](https://gnomad.broadinstitute.org/data#v4). We are not currently planning to update the Ensembl VEP version for other genes in the gnomAD browser. #### LOFTEE