|
| 1 | +# Build Notes for hidive |
| 2 | + |
| 3 | +## System Dependencies |
| 4 | + |
| 5 | +### sdsl-lite (vgteam fork) |
| 6 | + |
| 7 | +The `odgi-ffi` dependency requires sdsl-lite, which has known compilation issues with newer Clang versions. The vgteam fork (https://github.com/vgteam/sdsl-lite) includes fixes for these issues. |
| 8 | + |
| 9 | +**Installation:** |
| 10 | + |
| 11 | +```bash |
| 12 | +# Install the vgteam fork of sdsl-lite system-wide |
| 13 | +# This can be done via Homebrew or by building from source: |
| 14 | +git clone https://github.com/vgteam/sdsl-lite.git |
| 15 | +cd sdsl-lite |
| 16 | +mkdir build && cd build |
| 17 | +cmake .. |
| 18 | +make |
| 19 | +sudo make install |
| 20 | +``` |
| 21 | + |
| 22 | +### OpenMP (libomp) |
| 23 | + |
| 24 | +OpenMP is required for sdsl-lite compilation. |
| 25 | + |
| 26 | +**Installation on macOS:** |
| 27 | + |
| 28 | +```bash |
| 29 | +brew install libomp |
| 30 | +``` |
| 31 | + |
| 32 | +### Build Configuration |
| 33 | + |
| 34 | +When building, ensure the system-installed sdsl-lite and OpenMP are found by setting: |
| 35 | + |
| 36 | +```bash |
| 37 | +export CMAKE_PREFIX_PATH="/opt/homebrew/opt/libomp:$CMAKE_PREFIX_PATH" |
| 38 | +export CFLAGS="-I/opt/homebrew/opt/libomp/include" |
| 39 | +export CXXFLAGS="-I/opt/homebrew/opt/libomp/include" |
| 40 | +export LDFLAGS="-L/opt/homebrew/opt/libomp/lib" |
| 41 | +export CMAKE_ARGS="-Dsdsl-lite_ROOT=/usr/local/include -DOpenMP_C_INCLUDE_DIR=/opt/homebrew/opt/libomp/include -DOpenMP_CXX_INCLUDE_DIR=/opt/homebrew/opt/libomp/include -DOpenMP_C_LIB_NAMES=omp -DOpenMP_CXX_LIB_NAMES=omp -DOpenMP_omp_LIBRARY=/opt/homebrew/opt/libomp/lib/libomp.dylib -DCMAKE_C_FLAGS=-I/opt/homebrew/opt/libomp/include -DCMAKE_CXX_FLAGS=-I/opt/homebrew/opt/libomp/include" |
| 42 | +``` |
| 43 | + |
| 44 | +Or add these to your shell profile for persistent configuration. |
| 45 | + |
| 46 | +**Note:** The vgteam fork of sdsl-lite fixes the `louds_tree.hpp` compilation issues that occur with newer Clang versions. Make sure you have this version installed system-wide rather than relying on the bundled version in odgi-ffi. |
| 47 | + |
| 48 | +## odgi-ffi Status |
| 49 | + |
| 50 | +The `odgi-ffi` crate is **disabled** due to build issues with Clang 17+ and the `atomic_queue` dependency. Instead, hidive uses a modular approach: |
| 51 | + |
| 52 | +### Design Decision |
| 53 | + |
| 54 | +**Users prepare ODGI graphs externally** using the command-line `odgi` tool. This approach: |
| 55 | +- Avoids build complexity and dependency issues |
| 56 | +- Allows users to use their preferred graph construction tools |
| 57 | +- Makes the workflow more modular and debuggable |
| 58 | +- Enables reuse of graphs across multiple analyses |
| 59 | + |
| 60 | +### Workflow |
| 61 | + |
| 62 | +1. **Build pangenome graph**: `hidive build-pangenome` outputs a GFA file |
| 63 | +2. **Convert to ODGI**: Users run `odgi build -g <gfa> -o <odgi>` (external tool) |
| 64 | +3. **Use ODGI graph**: `hidive train-crf` and `hidive infer-haplotypes` accept ODGI files |
| 65 | + |
| 66 | +See `PANGENOME_WORKFLOW.md` for detailed instructions. |
| 67 | + |
| 68 | +### Dependencies |
| 69 | + |
| 70 | +- **seqwish**: Included as Rust dependency, used by `build-pangenome` |
| 71 | +- **odgi**: Command-line tool, must be installed separately by users |
| 72 | + |
0 commit comments