| pmid | 11090615 | |||||||
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| title | Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. | |||||||
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| journal | Mol Cell | |||||||
| year | 2000 | |||||||
| full_text_available | false | |||||||
| doi | 10.1016/s1097-2765(00)00075-7 |
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.
Authors: Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH Journal: Mol Cell (2000) DOI: 10.1016/s1097-2765(00)00075-7
- Mol Cell. 2000 Oct;6(4):757-68. doi: 10.1016/s1097-2765(00)00075-7.
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.
Zheng L(1), Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH.
Author information: (1)Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, 78245, USA.
BRCA1 has been implicated in the transcriptional regulation of DNA damage-inducible genes that function in cell cycle arrest. To explore the mechanistic basis for this regulation, a novel human gene, ZBRK1, which encodes a 60 kDa protein with an N-terminal KRAB domain and eight central zinc fingers, was identified by virtue of its interaction with BRCA1 in vitro and in vivo. ZBRK1 binds to a specific sequence, GGGxxx CAGxxxTTT, within GADD45 intron 3 that supports the assembly of a nuclear complex minimally containing both ZBRK1 and BRCA1. ZBRK1 represses transcription through this recognition sequence in a BRCA1-dependent manner. These results thus reveal a novel corepressor function for BRCA1 and provide a mechanistic basis for the biological activity of BRCA1 through sequence-specific transcriptional regulation.
DOI: 10.1016/s1097-2765(00)00075-7 PMID: 11090615 [Indexed for MEDLINE]