CRISPRoff #3
Description
From https://github.com/Jfortin1/crisprScore/issues/5:
Hi,
I have been using your new CRISPR Design tools recently and found it to be very helpful in CRISPR gRNA design. While I was searching for the best performing off-target prediction algorithms, I found those two more recent method: Microsoft ML-based Elevation score (sister algorithm of the Azimuth on-target prediction), and the gRNA binding free energy based ML algorithm-CRISPRoff.
Both showed superior performance than the MIT score and CDF scores, especially the CRIPSRoff Score.
I wonder if you could integrate those two methods in your off-target prediction methods collection. Below are the links:
https://github.com/microsoft/Elevation
https://github.com/RTH-tools/crisproff
Thank you for considering.
Best,
Zhibo