diff --git a/BuildMacOSUniversalBinary.py b/BuildMacOSUniversalBinary.py
index ddf30d9ea00e..3c1f68b05c64 100755
--- a/BuildMacOSUniversalBinary.py
+++ b/BuildMacOSUniversalBinary.py
@@ -60,10 +60,6 @@
     # permissions needed for ARM builds
     "codesign_identity":  "-",
 
-    # Minimum macOS version for each architecture slice
-    "arm64_mac_os_deployment_target":  "11.0.0",
-    "x86_64_mac_os_deployment_target": "10.15.0",
-
     # CMake Generator to use for building
     "generator": "Unix Makefiles",
     "build_type": "Release",
@@ -146,11 +142,6 @@ def parse_args(conf=DEFAULT_CONFIG):
              help=f"Install path for {arch} qt5 libraries",
              default=conf[arch+"_qt5_path"])
 
-        parser.add_argument(
-             f"--{arch}_mac_os_deployment_target",
-             help=f"Deployment architecture for {arch} slice",
-             default=conf[arch+"_mac_os_deployment_target"])
-
     return vars(parser.parse_args())
 
 
@@ -297,8 +288,6 @@ def build(config):
                 "-DCMAKE_PREFIX_PATH="+prefix_path,
                 "-DCMAKE_SYSTEM_PROCESSOR="+arch,
                 "-DCMAKE_IGNORE_PATH="+ignore_path,
-                "-DCMAKE_OSX_DEPLOYMENT_TARGET="
-                + config[arch+"_mac_os_deployment_target"],
                 "-DMACOS_CODE_SIGNING_IDENTITY="
                 + config["codesign_identity"],
                 '-DMACOS_CODE_SIGNING="ON"',
diff --git a/CMakeLists.txt b/CMakeLists.txt
index f2fcabd64f0b..8303a3c423c1 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -24,7 +24,7 @@ endif()
 
 # Minimum OS X version.
 # This is inserted into the Info.plist as well.
-set(CMAKE_OSX_DEPLOYMENT_TARGET "10.15.0" CACHE STRING "")
+set(CMAKE_OSX_DEPLOYMENT_TARGET "11.0.0" CACHE STRING "")
 
 set(CMAKE_USER_MAKE_RULES_OVERRIDE "${CMAKE_CURRENT_SOURCE_DIR}/CMake/FlagsOverride.cmake")
 
diff --git a/Readme.md b/Readme.md
index 5a4e5363b334..fde13cc3f877 100644
--- a/Readme.md
+++ b/Readme.md
@@ -15,7 +15,7 @@ Please read the [FAQ](https://dolphin-emu.org/docs/faq/) before using Dolphin.
 * OS
     * Windows (10 1903 or higher).
     * Linux.
-    * macOS (10.15 Catalina or higher).
+    * macOS (11.0 Big Sur or higher).
     * Unix-like systems other than Linux are not officially supported but might work.
 * Processor
     * A CPU with SSE2 support.
diff --git a/Source/Core/Common/MemoryUtil.cpp b/Source/Core/Common/MemoryUtil.cpp
index 2cd393d098ad..f4759c41a057 100644
--- a/Source/Core/Common/MemoryUtil.cpp
+++ b/Source/Core/Common/MemoryUtil.cpp
@@ -97,10 +97,7 @@ void JITPageWriteEnableExecuteDisable()
 #if defined(_M_ARM_64) && defined(__APPLE__)
   if (JITPageWriteNestCounter() == 0)
   {
-    if (__builtin_available(macOS 11.0, *))
-    {
-      pthread_jit_write_protect_np(0);
-    }
+    pthread_jit_write_protect_np(0);
   }
 #endif
   JITPageWriteNestCounter()++;
@@ -119,10 +116,7 @@ void JITPageWriteDisableExecuteEnable()
 #if defined(_M_ARM_64) && defined(__APPLE__)
   if (JITPageWriteNestCounter() == 0)
   {
-    if (__builtin_available(macOS 11.0, *))
-    {
-      pthread_jit_write_protect_np(1);
-    }
+    pthread_jit_write_protect_np(1);
   }
 #endif
 }
diff --git a/Source/Core/VideoBackends/Metal/MTLUtil.mm b/Source/Core/VideoBackends/Metal/MTLUtil.mm
index 469e4f7df87e..940c4f293b87 100644
--- a/Source/Core/VideoBackends/Metal/MTLUtil.mm
+++ b/Source/Core/VideoBackends/Metal/MTLUtil.mm
@@ -262,15 +262,10 @@ fragment float4 is_helper_test() {
   backend_info->bSupportsST3CTextures = true;
   backend_info->bSupportsBPTCTextures = true;
 #else
-  bool supports_apple4 = false;
-  bool supports_bcn = false;
-  if (@available(iOS 13, *))
-    supports_apple4 = [device supportsFamily:MTLGPUFamilyApple4];
-  else
-    supports_apple4 = [device supportsFeatureSet:MTLFeatureSet_iOS_GPUFamily4_v1];
+  backend_info->bSupportsDepthClamp = [device supportsFamily:MTLGPUFamilyApple4];
+
   if (@available(iOS 16.4, *))
     supports_bcn = [device supportsBCTextureCompression];
-  backend_info->bSupportsDepthClamp = supports_apple4;
   backend_info->bSupportsST3CTextures = supports_bcn;
   backend_info->bSupportsBPTCTextures = supports_bcn;
 
@@ -295,9 +290,8 @@ fragment float4 is_helper_test() {
   case TriState::Auto:
 #if TARGET_OS_OSX
     g_features.manual_buffer_upload = false;
-    if (@available(macOS 10.15, *))
-      if (![device hasUnifiedMemory])
-        g_features.manual_buffer_upload = true;
+    if (![device hasUnifiedMemory])
+      g_features.manual_buffer_upload = true;
 #else
     // All iOS devices have unified memory
     g_features.manual_buffer_upload = false;
@@ -305,14 +299,8 @@ fragment float4 is_helper_test() {
     break;
   }
 
-  g_features.subgroup_ops = false;
-  if (@available(macOS 10.15, iOS 13, *))
-  {
-    // Requires SIMD-scoped reduction operations
-    g_features.subgroup_ops =
-        [device supportsFamily:MTLGPUFamilyMac2] || [device supportsFamily:MTLGPUFamilyApple7];
-    backend_info->bSupportsFramebufferFetch = [device supportsFamily:MTLGPUFamilyApple1];
-  }
+  g_features.subgroup_ops =
+      [device supportsFamily:MTLGPUFamilyMac2] || [device supportsFamily:MTLGPUFamilyApple7];
   if (g_features.subgroup_ops)
   {
     DetectionResult result = DetectInvertedIsHelper(device);
@@ -323,11 +311,13 @@ fragment float4 is_helper_test() {
         DriverDetails::OverrideBug(DriverDetails::BUG_INVERTED_IS_HELPER, is_helper_inverted);
     }
   }
+
+  backend_info->bSupportsFramebufferFetch = [device supportsFamily:MTLGPUFamilyApple1];
 #if TARGET_OS_OSX
-  if (@available(macOS 11, *))
-    if (vendor == DriverDetails::VENDOR_INTEL)
-      backend_info->bSupportsFramebufferFetch |= DetectIntelGPUFBFetch(device);
+  if (vendor == DriverDetails::VENDOR_INTEL)
+    backend_info->bSupportsFramebufferFetch |= DetectIntelGPUFBFetch(device);
 #endif
+
   if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_DYNAMIC_SAMPLER_INDEXING))
     backend_info->bSupportsDynamicSamplerIndexing = false;
 }
@@ -570,14 +560,7 @@ fragment float4 is_helper_test() {
 
   spirv_cross::CompilerMSL compiler(std::move(*code));
 
-  if (@available(macOS 11, iOS 14, *))
-    options.set_msl_version(2, 3);
-  else if (@available(macOS 10.15, iOS 13, *))
-    options.set_msl_version(2, 2);
-  else if (@available(macOS 10.14, iOS 12, *))
-    options.set_msl_version(2, 1);
-  else
-    options.set_msl_version(2, 0);
+  options.set_msl_version(2, 3);
   options.use_framebuffer_fetch_subpasses = true;
   compiler.set_msl_options(options);