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Perform analysis of ONT/PacBio HiFi sequencing data from PCR of HEK293T-COX3 mutant allelic series samples (using stable copy of MitoHPC2) #7

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@kbonsu

I have long-read sequencing data on Rockfish at [ONT: ~/data_darking1/projects/mito/Heteroplasmy/long_read_seq/Timp_ONT_runOct2025_demuxed/] and [HiFi: /data/darking1/projects/mito/Heteroplasmy/long_read_seq/UMB_PacBio_runDec2025/251012_arking_mtDNA_fl/PACBIO_DATA]. This data was generated by isolating DNA from HEK cells harboring a truncating mutation in the COX3 gene (mt.9979G>A), and performing long-range PCR targeted to the mitochondria. Reads were adapter trimmed, and aligned, prior to processing with a stable copy of MitoHPC2.

Currently working on interpreting the {caller}.vcf outputs at [/data/darking1/projects/mito/Heteroplasmy/long_read_seq/MitoProcess_R_ana_Mar13/Sample_Agg2/Sample_Summ1]

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