diff --git a/easybuild/easyconfigs/m/medaka/medaka-2.2.2-foss-2025a-CUDA-12.8.0.eb b/easybuild/easyconfigs/m/medaka/medaka-2.2.2-foss-2025a-CUDA-12.8.0.eb
new file mode 100644
index 000000000000..3e4605c57feb
--- /dev/null
+++ b/easybuild/easyconfigs/m/medaka/medaka-2.2.2-foss-2025a-CUDA-12.8.0.eb
@@ -0,0 +1,102 @@
+# This is a contribution from HPCNow! (http://hpcnow.com)
+# Copyright::   HPCNow!
+# Authors::     Danilo Gonzalez <danilo.gonzalez@hpcnow.com>
+# License::     GPL-v3.0
+# Updated to foss-2020b to use with artic tool
+# J. Sassmannshausen (GSTT/NHS UK)
+# Updated to 1.5.0
+# Jasper Grimm (UoY)
+# Updated: Petr Král (INUITS)
+# Updated: Emik Lin (HKUMed CPOS)
+
+easyblock = 'PythonBundle'
+
+name = 'medaka'
+version = '2.2.2'
+versionsuffix = '-CUDA-%(cudaver)s'
+
+homepage = 'https://github.com/nanoporetech/medaka'
+description = "medaka is a tool to create a consensus sequence from nanopore sequencing data."
+
+toolchain = {'name': 'foss', 'version': '2025a'}
+toolchainopts = {'pic': True}
+
+builddependencies = [
+    ('Autotools', '20240712'),
+    ('Cython', '3.1.1'),
+    ('CMake', '3.31.3'),
+    ('setuptools', '80.9.0'),
+    ('poetry', '2.1.2'),
+]
+
+_minimap_ver = '2.30'
+dependencies = [
+    ('CUDA', '12.8.0', '', SYSTEM),
+    ('Python', '3.13.1'),
+    ('Python-bundle-PyPI', '2025.04'),  # includes cffi
+    ('Pysam', '0.23.3'),
+    ('SAMtools', '1.22.1'),
+    ('minimap2', _minimap_ver),
+    ('HTSlib', '1.22.1'),  # for tabix and bgzip
+    ('edlib', '1.3.9.post1'),
+    ('pyspoa', '0.2.1'),
+    ('python-parasail', '1.3.4'),
+    ('ont-fast5-api', '4.1.3'),
+    ('WhatsHap', '2.6'),
+    ('intervaltree-python', '3.2.1'),
+    ('BCFtools', '1.22'),
+    ('h5py', '3.14.0'),
+    ('PyTorch', '2.9.1', f'{versionsuffix}-whl'),
+    ('PyTorch-bundle', '2.9.1', f'{versionsuffix}-whl'),  # provides tensordict
+    ('tqdm', '4.67.1'),
+    ('wurlitzer', '3.1.1'),
+]
+
+local_sed_commands = [
+    # ont-parasail on PyPI is just pre-built wheels for (python-)parasail
+    "sed -i 's/ont-parasail/parasail/g' requirements.txt",
+    # ont-mappy on PyPI is just pre-built wheels for mappy
+    "sed -i 's/ont-mappy/mappy/g' requirements.txt",
+    # pysam was only restricted to <=0.23.0 to work with test coverage
+    "sed -i 's/pysam>=0.16.0.1,<=0.23.0/pysam>=0.16.0.1/g' requirements.txt",
+]
+
+exts_list = [
+    ('mappy', _minimap_ver, {
+        'checksums': ['a25448004558a28cb0d74fb1e55b6ffe9a78aa15dd6b2763630fbbabbaa97a27'],
+    }),
+    ('pyabpoa', '1.5.6', {
+        'checksums': ['265f638c7fed0cde78cf0593c9e36121c1e718de1c73d7fa527dd62a7f90f191'],
+        'preinstallopts': "sed -i 's/license = \"MIT\"/license = {text = \"MIT\"}/' pyproject.toml && SSE2=1 ",
+    }),
+    (name, version, {
+        'patches': ['medaka-2.2.1_use-system-htslib.patch'],
+        'preinstallopts': " && ".join(local_sed_commands) + " && ",
+        'use_pip_extras': 'abpoa',
+        'checksums': [
+            '28ed7402af5c82aa5d62c28325c1b1d6961b69d3ee16b624f44a5dbc34edf44e',  # medaka-2.2.2.tar.gz
+            '2d3d43c912d4d238032781df2b4e30c8e7bbd09c05ac2fee3cdb96edb09f8419',  # system HTSlib patch
+        ],
+    }),
+]
+
+sanity_check_paths = {
+    'files': [
+        'bin/medaka',
+        'bin/medaka_consensus',
+        'bin/medaka_consensus_joint',
+        'bin/medaka_counts',
+        'bin/medaka_data_path',
+        'bin/medaka_variant',
+        'bin/medaka_version_report',
+        'bin/mini_align',
+    ],
+    'dirs': ['lib/python%(pyshortver)s/site-packages/medaka'],
+}
+
+sanity_check_commands = [
+    'medaka --help',
+    'medaka_version_report',
+]
+
+moduleclass = 'bio'
diff --git a/easybuild/easyconfigs/m/medaka/medaka-2.2.2-foss-2025a.eb b/easybuild/easyconfigs/m/medaka/medaka-2.2.2-foss-2025a.eb
new file mode 100644
index 000000000000..3a6703b26139
--- /dev/null
+++ b/easybuild/easyconfigs/m/medaka/medaka-2.2.2-foss-2025a.eb
@@ -0,0 +1,100 @@
+# This is a contribution from HPCNow! (http://hpcnow.com)
+# Copyright::   HPCNow!
+# Authors::     Danilo Gonzalez <danilo.gonzalez@hpcnow.com>
+# License::     GPL-v3.0
+# Updated to foss-2020b to use with artic tool
+# J. Sassmannshausen (GSTT/NHS UK)
+# Updated to 1.5.0
+# Jasper Grimm (UoY)
+# Updated: Petr Král (INUITS)
+# Updated: Emik Lin (HKUMed CPOS)
+
+easyblock = 'PythonBundle'
+
+name = 'medaka'
+version = '2.2.2'
+
+homepage = 'https://github.com/nanoporetech/medaka'
+description = "medaka is a tool to create a consensus sequence from nanopore sequencing data."
+
+toolchain = {'name': 'foss', 'version': '2025a'}
+toolchainopts = {'pic': True}
+
+builddependencies = [
+    ('Autotools', '20240712'),
+    ('Cython', '3.1.1'),
+    ('CMake', '3.31.3'),
+    ('setuptools', '80.9.0'),
+    ('poetry', '2.1.2'),
+]
+
+_minimap_ver = '2.30'
+dependencies = [
+    ('Python', '3.13.1'),
+    ('Python-bundle-PyPI', '2025.04'),  # includes cffi
+    ('Pysam', '0.23.3'),
+    ('SAMtools', '1.22.1'),
+    ('minimap2', _minimap_ver),
+    ('HTSlib', '1.22.1'),  # for tabix and bgzip
+    ('edlib', '1.3.9.post1'),
+    ('pyspoa', '0.2.1'),
+    ('python-parasail', '1.3.4'),
+    ('ont-fast5-api', '4.1.3'),
+    ('WhatsHap', '2.6'),
+    ('intervaltree-python', '3.2.1'),
+    ('BCFtools', '1.22'),
+    ('h5py', '3.14.0'),
+    ('PyTorch', '2.9.1', '-whl'),
+    ('PyTorch-bundle', '2.9.1', '-whl'),  # provides tensordict
+    ('tqdm', '4.67.1'),
+    ('wurlitzer', '3.1.1'),
+]
+
+local_sed_commands = [
+    # ont-parasail on PyPI is just pre-built wheels for (python-)parasail
+    "sed -i 's/ont-parasail/parasail/g' requirements.txt",
+    # ont-mappy on PyPI is just pre-built wheels for mappy
+    "sed -i 's/ont-mappy/mappy/g' requirements.txt",
+    # pysam was only restricted to <=0.23.0 to work with test coverage
+    "sed -i 's/pysam>=0.16.0.1,<=0.23.0/pysam>=0.16.0.1/g' requirements.txt",
+]
+
+exts_list = [
+    ('mappy', _minimap_ver, {
+        'checksums': ['a25448004558a28cb0d74fb1e55b6ffe9a78aa15dd6b2763630fbbabbaa97a27'],
+    }),
+    ('pyabpoa', '1.5.6', {
+        'checksums': ['265f638c7fed0cde78cf0593c9e36121c1e718de1c73d7fa527dd62a7f90f191'],
+        'preinstallopts': "sed -i 's/license = \"MIT\"/license = {text = \"MIT\"}/' pyproject.toml && SSE2=1 ",
+    }),
+    (name, version, {
+        'patches': ['medaka-2.2.1_use-system-htslib.patch'],
+        'preinstallopts': " && ".join(local_sed_commands) + " && ",
+        'use_pip_extras': 'abpoa',
+        'checksums': [
+            '28ed7402af5c82aa5d62c28325c1b1d6961b69d3ee16b624f44a5dbc34edf44e',  # medaka-2.2.2.tar.gz
+            '2d3d43c912d4d238032781df2b4e30c8e7bbd09c05ac2fee3cdb96edb09f8419',  # system HTSlib patch
+        ],
+    }),
+]
+
+sanity_check_paths = {
+    'files': [
+        'bin/medaka',
+        'bin/medaka_consensus',
+        'bin/medaka_consensus_joint',
+        'bin/medaka_counts',
+        'bin/medaka_data_path',
+        'bin/medaka_variant',
+        'bin/medaka_version_report',
+        'bin/mini_align',
+    ],
+    'dirs': ['lib/python%(pyshortver)s/site-packages/medaka'],
+}
+
+sanity_check_commands = [
+    'medaka --help',
+    'medaka_version_report',
+]
+
+moduleclass = 'bio'