diff --git a/x-pack/solutions/security/plugins/security_solution/public/management/cypress/e2e/artifacts/endpoint_exceptions.cy.ts b/x-pack/solutions/security/plugins/security_solution/public/management/cypress/e2e/artifacts/endpoint_exceptions.cy.ts
index e84692fe49a17..1fa1e108795a3 100644
--- a/x-pack/solutions/security/plugins/security_solution/public/management/cypress/e2e/artifacts/endpoint_exceptions.cy.ts
+++ b/x-pack/solutions/security/plugins/security_solution/public/management/cypress/e2e/artifacts/endpoint_exceptions.cy.ts
@@ -154,7 +154,8 @@ describe(
       });
     });
 
-    describe('OR operator', { tags: ['@ess', '@serverless'] }, () => {
+    // Skipped in Serverless MKI due to interactions with internal indices
+    describe('OR operator', { tags: ['@ess', '@serverless', '@skipInServerlessMKI'] }, () => {
       let endpointData: ReturnTypeFromChainable<typeof indexEndpointHosts> | undefined;
 
       const artifactNameActions: FormAction[] = [