diff --git a/src/primitives/Nonce/Nonce.test.ts b/src/primitives/Nonce/Nonce.test.ts
index 1548cdad2..2029fec31 100644
--- a/src/primitives/Nonce/Nonce.test.ts
+++ b/src/primitives/Nonce/Nonce.test.ts
@@ -29,7 +29,8 @@ describe("Nonce", () => {
 		});
 
 		it("creates large nonce", () => {
-			const large = 2n ** 200n;
+			// Max uint64 value
+			const large = 18446744073709551615n;
 			const nonce = Nonce.from(large);
 			expect(Nonce.toBigInt(nonce)).toBe(large);
 		});
diff --git a/src/primitives/Nonce/from.js b/src/primitives/Nonce/from.js
index c921320d3..38eb296c8 100644
--- a/src/primitives/Nonce/from.js
+++ b/src/primitives/Nonce/from.js
@@ -1,10 +1,20 @@
-import * as Uint from "../Uint/index.js";
+import {
+	IntegerOverflowError,
+	IntegerUnderflowError,
+	InvalidFormatError,
+} from "../errors/index.js";
+
+/** Maximum uint64 value (2^64 - 1) */
+const MAX_UINT64 = 18446744073709551615n;
 
 /**
  * Create Nonce from number, bigint, or hex string
  *
  * @param {bigint | number | string} value - Value to convert
  * @returns {import('./NonceType.js').NonceType} Nonce
+ * @throws {InvalidFormatError} If value is not a valid integer
+ * @throws {IntegerUnderflowError} If value is negative
+ * @throws {IntegerOverflowError} If value exceeds uint64 max (2^64-1)
  *
  * @example
  * ```typescript
@@ -14,7 +24,54 @@ import * as Uint from "../Uint/index.js";
  * ```
  */
 export function from(value) {
-	return /** @type {import('./NonceType.js').NonceType} */ (
-		/** @type {unknown} */ (Uint.from(value))
-	);
+	/** @type {bigint} */
+	let bigintValue;
+
+	if (typeof value === "string") {
+		try {
+			bigintValue = BigInt(value);
+		} catch {
+			throw new InvalidFormatError(`Invalid Nonce string: ${value}`, {
+				code: "NONCE_INVALID_STRING",
+				value,
+				expected: "decimal or 0x-prefixed hex string",
+				docsPath: "/primitives/nonce#error-handling",
+			});
+		}
+	} else if (typeof value === "number") {
+		if (!Number.isInteger(value)) {
+			throw new InvalidFormatError(`Nonce must be an integer: ${value}`, {
+				code: "NONCE_NOT_INTEGER",
+				value,
+				expected: "integer value",
+				docsPath: "/primitives/nonce#error-handling",
+			});
+		}
+		bigintValue = BigInt(value);
+	} else {
+		bigintValue = value;
+	}
+
+	if (bigintValue < 0n) {
+		throw new IntegerUnderflowError(`Nonce cannot be negative: ${bigintValue}`, {
+			value: bigintValue,
+			min: 0n,
+			type: "nonce",
+			docsPath: "/primitives/nonce#error-handling",
+		});
+	}
+
+	if (bigintValue > MAX_UINT64) {
+		throw new IntegerOverflowError(
+			`Nonce exceeds maximum uint64 (2^64-1): ${bigintValue}`,
+			{
+				value: bigintValue,
+				max: MAX_UINT64,
+				type: "nonce",
+				docsPath: "/primitives/nonce#error-handling",
+			},
+		);
+	}
+
+	return /** @type {import('./NonceType.js').NonceType} */ (bigintValue);
 }
diff --git a/src/primitives/Nonce/from.test.ts b/src/primitives/Nonce/from.test.ts
index 523ff185d..63818573d 100644
--- a/src/primitives/Nonce/from.test.ts
+++ b/src/primitives/Nonce/from.test.ts
@@ -1,5 +1,10 @@
 import { describe, expect, it } from "vitest";
 import { from } from "./from.js";
+import {
+	IntegerOverflowError,
+	IntegerUnderflowError,
+	InvalidFormatError,
+} from "../errors/index.js";
 
 describe("Nonce.from", () => {
 	it("creates nonce from number", () => {
@@ -24,4 +29,48 @@ describe("Nonce.from", () => {
 		const nonce = from(0);
 		expect(nonce).toBe(0n);
 	});
+
+	it("handles max uint64 nonce", () => {
+		const maxUint64 = 18446744073709551615n;
+		const nonce = from(maxUint64);
+		expect(nonce).toBe(maxUint64);
+	});
+
+	describe("validation", () => {
+		it("rejects negative number", () => {
+			expect(() => from(-1)).toThrow(IntegerUnderflowError);
+			expect(() => from(-1)).toThrow("Nonce cannot be negative");
+		});
+
+		it("rejects negative bigint", () => {
+			expect(() => from(-1n)).toThrow(IntegerUnderflowError);
+			expect(() => from(-1n)).toThrow("Nonce cannot be negative");
+		});
+
+		it("rejects negative hex string", () => {
+			// "-0x1" is not valid BigInt syntax, throws InvalidFormat
+			expect(() => from("-0x1")).toThrow(InvalidFormatError);
+			// "-1" is valid BigInt syntax, throws Underflow
+			expect(() => from("-1")).toThrow(IntegerUnderflowError);
+		});
+
+		it("rejects large negative values", () => {
+			expect(() => from(-9999999999n)).toThrow(IntegerUnderflowError);
+		});
+
+		it("rejects value exceeding uint64 max", () => {
+			const overMax = 18446744073709551616n; // 2^64
+			expect(() => from(overMax)).toThrow(IntegerOverflowError);
+			expect(() => from(overMax)).toThrow("exceeds maximum uint64");
+		});
+
+		it("rejects non-integer number", () => {
+			expect(() => from(1.5)).toThrow(InvalidFormatError);
+			expect(() => from(1.5)).toThrow("must be an integer");
+		});
+
+		it("rejects invalid string", () => {
+			expect(() => from("not-a-number")).toThrow(InvalidFormatError);
+		});
+	});
 });
diff --git a/src/primitives/Nonce/toBigInt.test.ts b/src/primitives/Nonce/toBigInt.test.ts
index 4263bb1b4..3c120a440 100644
--- a/src/primitives/Nonce/toBigInt.test.ts
+++ b/src/primitives/Nonce/toBigInt.test.ts
@@ -50,7 +50,8 @@ describe("Nonce.toBigInt", () => {
 		});
 
 		it("preserves large values", () => {
-			const original = 2n ** 200n;
+			// Max uint64 value
+			const original = 18446744073709551615n;
 			const nonce = Nonce.from(original);
 			const result = Nonce.toBigInt(nonce);
 			expect(result).toBe(original);
diff --git a/src/primitives/Nonce/toNumber.test.ts b/src/primitives/Nonce/toNumber.test.ts
index 2b6313ed3..1fa7cec9d 100644
--- a/src/primitives/Nonce/toNumber.test.ts
+++ b/src/primitives/Nonce/toNumber.test.ts
@@ -60,7 +60,8 @@ describe("Nonce.toNumber", () => {
 		});
 
 		it("throws on very large value", () => {
-			const nonce = Nonce.from(2n ** 100n);
+			// Use a value larger than MAX_SAFE_INTEGER but within uint64 range
+			const nonce = Nonce.from(BigInt(Number.MAX_SAFE_INTEGER) + 1000n);
 			expect(() => Nonce.toNumber(nonce)).toThrow();
 		});
 	});