tooluniverse-disease-research

ToolUniverse Disease Research Skill

Generate comprehensive, detailed disease research reports with full source citations using 100+ ToolUniverse tools.

Key Principles

1. Report-First: Create a markdown file first, then populate it during research
2. Progressive Updates: Update the report file after each research dimension
3. Full Citations: Every data point references its source tool
4. Comprehensive: Use ALL relevant tools, not just a subset
5. No Process Display: Don't show the search process, just deliver the report

Workflow

User: "Research Parkinson's disease"

Agent (internal actions - NOT shown to user):
1. Create "parkinsons_disease_research_report.md"
2. Research each of 10 dimensions
3. Update report file after each dimension
4. Track all tool usage for references

Agent (to user):
→ Presents final comprehensive report

Report Structure (10 Sections)

#	Section	Tools Used	Content
1	Identity & Classification	OSL, OLS, UMLS, ICD, SNOMED	IDs, synonyms, hierarchy
2	Clinical Presentation	OpenTargets, HPO, MedlinePlus	Phenotypes, symptoms
3	Genetic Basis	OpenTargets, ClinVar, GWAS	Genes, variants, associations
4	Treatment Landscape	OpenTargets, ClinicalTrials, GtoPdb	Drugs, trials, pipeline
5	Pathways & Mechanisms	Reactome, HumanBase, GTEx, HPA	Pathways, PPI, expression
6	Literature	PubMed, OpenAlex, Europe PMC	Publications, trends
7	Similar Diseases	OpenTargets	Related conditions
8	Cancer-Specific	CIViC	Variants, evidence (if cancer)
9	Pharmacology	GtoPdb	Targets, interactions
10	Drug Safety	OpenTargets, FAERS	Warnings, adverse events

Citation Format

Every data point includes its source:

| Gene | Score | Source |
|------|-------|--------|
| APOE | 0.92 | OpenTargets_get_associated_targets_by_disease_efoId |

Report Size

A comprehensive disease report should include:

• 500+ individual data points
• All 10 sections populated
• Complete references section
• 2000+ lines for major diseases

Files

File	Purpose
SKILL.md	Complete protocol with tool usage
TOOLS_REFERENCE.md	Tool documentation and examples
EXAMPLES.md	Sample report outputs
README.md	This overview

When to Use

• User asks about any disease/syndrome
• Need comprehensive disease intelligence
• Want detailed report with citations
• Researching disease mechanisms, genetics, or treatments