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Description
Currently, it seems that the way you could programmatically execute Runes natively is with Rust, C or something with WASM.
As @Michael-F-Bryan mentioned before, support for other languages could be obtained through the implementation of bindings through C++.
However, it also worthy to note that there may be a decent amount of maintainance associated with each language binding because of documentation and changes that need to be made when a particular feature changes.