diff --git a/.changeset/routing-ism-batch-ops.md b/.changeset/routing-ism-batch-ops.md
new file mode 100644
index 00000000000..fb731ba2956
--- /dev/null
+++ b/.changeset/routing-ism-batch-ops.md
@@ -0,0 +1,5 @@
+---
+'@hyperlane-xyz/core': minor
+---
+
+Added `setBatch(DomainModule[])` and `removeBatch(uint32[])` to `DomainRoutingIsm` so routing ISM owners can enroll or unenroll many domains in a single transaction after initialization. Mirrors the `setHooks(HookConfig[])` pattern on `DomainRoutingHook`. Inherited by `IncrementalDomainRoutingIsm` (where `removeBatch` reverts, consistent with `remove`) and `DefaultFallbackRoutingIsm`.
diff --git a/solidity/contracts/isms/routing/DomainRoutingIsm.sol b/solidity/contracts/isms/routing/DomainRoutingIsm.sol
index a627df4b866..20175a1c70e 100644
--- a/solidity/contracts/isms/routing/DomainRoutingIsm.sol
+++ b/solidity/contracts/isms/routing/DomainRoutingIsm.sol
@@ -32,6 +32,12 @@ contract DomainRoutingIsm is
     // ============ Mutable Storage ============
     EnumerableMapExtended.UintToBytes32Map internal _modules;
 
+    // ============ Structs ============
+    struct DomainModule {
+        uint32 domain;
+        IInterchainSecurityModule module;
+    }
+
     // ============ External Functions ============
 
     /**
@@ -74,6 +80,18 @@ contract DomainRoutingIsm is
         _set(_domain, address(_module));
     }
 
+    /**
+     * @notice Sets the ISMs to be used for the specified origin domains
+     * @param _domainModules The origin domains and ISMs to enroll
+     */
+    function setBatch(
+        DomainModule[] calldata _domainModules
+    ) external onlyOwner {
+        for (uint256 i = 0; i < _domainModules.length; ++i) {
+            _set(_domainModules[i].domain, address(_domainModules[i].module));
+        }
+    }
+
     /**
      * @notice Removes the specified origin domain
      * @param _domain The origin domain
@@ -82,6 +100,16 @@ contract DomainRoutingIsm is
         _remove(_domain);
     }
 
+    /**
+     * @notice Removes the specified origin domains
+     * @param _domains The origin domains to remove
+     */
+    function removeBatch(uint32[] calldata _domains) external onlyOwner {
+        for (uint256 i = 0; i < _domains.length; ++i) {
+            _remove(_domains[i]);
+        }
+    }
+
     function domains() external view returns (uint256[] memory) {
         return _modules.keys();
     }
diff --git a/solidity/test/isms/DomainRoutingIsm.t.sol b/solidity/test/isms/DomainRoutingIsm.t.sol
index c18f3294175..2ec053d5869 100644
--- a/solidity/test/isms/DomainRoutingIsm.t.sol
+++ b/solidity/test/isms/DomainRoutingIsm.t.sol
@@ -37,6 +37,76 @@ contract DomainRoutingIsmTest is Test {
         assertEq(address(ism.module(domain)), address(_ism));
     }
 
+    function buildDomainModules(
+        uint32 domain,
+        uint8 count
+    ) internal returns (DomainRoutingIsm.DomainModule[] memory) {
+        DomainRoutingIsm.DomainModule[]
+            memory domainModules = new DomainRoutingIsm.DomainModule[](count);
+        for (uint32 i = 0; i < count; ++i) {
+            unchecked {
+                domainModules[i] = DomainRoutingIsm.DomainModule({
+                    domain: domain + i,
+                    module: IInterchainSecurityModule(
+                        address(deployTestIsm(bytes32(0)))
+                    )
+                });
+            }
+        }
+        return domainModules;
+    }
+
+    function testSetBatch(uint32 domain, uint8 count) public {
+        vm.assume(count > 0);
+        DomainRoutingIsm.DomainModule[]
+            memory domainModules = buildDomainModules(domain, count);
+
+        ism.setBatch(domainModules);
+        for (uint256 i = 0; i < count; ++i) {
+            assertEq(
+                address(ism.module(domainModules[i].domain)),
+                address(domainModules[i].module)
+            );
+        }
+    }
+
+    function testSetBatchNonOwner(uint32 domain) public {
+        DomainRoutingIsm.DomainModule[]
+            memory domainModules = new DomainRoutingIsm.DomainModule[](1);
+        domainModules[0] = DomainRoutingIsm.DomainModule({
+            domain: domain,
+            module: IInterchainSecurityModule(address(0))
+        });
+        vm.prank(NON_OWNER);
+        vm.expectRevert("Ownable: caller is not the owner");
+        ism.setBatch(domainModules);
+    }
+
+    function testRemoveBatch(uint32 domain, uint8 count) public virtual {
+        vm.assume(count > 0);
+        DomainRoutingIsm.DomainModule[]
+            memory domainModules = buildDomainModules(domain, count);
+        ism.setBatch(domainModules);
+
+        uint32[] memory domains = new uint32[](count);
+        for (uint256 i = 0; i < count; ++i) {
+            domains[i] = domainModules[i].domain;
+        }
+        ism.removeBatch(domains);
+        for (uint256 i = 0; i < count; ++i) {
+            vm.expectRevert();
+            ism.module(domains[i]);
+        }
+    }
+
+    function testRemoveBatchNonOwner(uint32 domain) public {
+        uint32[] memory domains = new uint32[](1);
+        domains[0] = domain;
+        vm.prank(NON_OWNER);
+        vm.expectRevert("Ownable: caller is not the owner");
+        ism.removeBatch(domains);
+    }
+
     function testRemove(uint32 domain) public virtual {
         vm.expectRevert();
         ism.remove(domain);
@@ -123,6 +193,22 @@ contract DefaultFallbackRoutingIsmTest is DomainRoutingIsmTest {
         new DefaultFallbackRoutingIsm(address(0));
     }
 
+    function testRemoveBatch(uint32 domain, uint8 count) public override {
+        vm.assume(count > 0);
+        DomainRoutingIsm.DomainModule[]
+            memory domainModules = buildDomainModules(domain, count);
+        ism.setBatch(domainModules);
+
+        uint32[] memory domains = new uint32[](count);
+        for (uint256 i = 0; i < count; ++i) {
+            domains[i] = domainModules[i].domain;
+        }
+        ism.removeBatch(domains);
+        for (uint256 i = 0; i < count; ++i) {
+            assertEq(address(ism.module(domains[i])), address(defaultIsm));
+        }
+    }
+
     function testVerifyNoIsm(uint32 domain, bytes32 seed) public override {
         vm.assume(domain > 0);
         ism.set(domain, deployTestIsm(seed));
diff --git a/solidity/test/isms/IncrementalDomainRoutingIsm.t.sol b/solidity/test/isms/IncrementalDomainRoutingIsm.t.sol
index 8d77dfae361..42b993ca8e4 100644
--- a/solidity/test/isms/IncrementalDomainRoutingIsm.t.sol
+++ b/solidity/test/isms/IncrementalDomainRoutingIsm.t.sol
@@ -5,6 +5,7 @@ import "forge-std/Test.sol";
 
 import {IncrementalDomainRoutingIsm} from "../../contracts/isms/routing/IncrementalDomainRoutingIsm.sol";
 import {IncrementalDomainRoutingIsmFactory} from "../../contracts/isms/routing/IncrementalDomainRoutingIsmFactory.sol";
+import {DomainRoutingIsm} from "../../contracts/isms/routing/DomainRoutingIsm.sol";
 import {DomainRoutingIsmTest} from "./DomainRoutingIsm.t.sol";
 import {IInterchainSecurityModule} from "../../contracts/interfaces/IInterchainSecurityModule.sol";
 import {TestIsm} from "./IsmTestUtils.sol";
@@ -29,6 +30,18 @@ contract IncrementalDomainRoutingIsmTest is DomainRoutingIsmTest {
         ism.remove(domain);
     }
 
+    function testRemoveBatch(uint32 domain, uint8 count) public override {
+        vm.assume(count > 0);
+        uint32[] memory domains = new uint32[](count);
+        for (uint32 i = 0; i < count; ++i) {
+            unchecked {
+                domains[i] = domain + i;
+            }
+        }
+        vm.expectRevert("IncrementalDomainRoutingIsm: removal not supported");
+        ism.removeBatch(domains);
+    }
+
     function testSetTwiceReverts(uint32 domain) public {
         TestIsm _ism = deployTestIsm(bytes32(0));
         TestIsm _ism2 = deployTestIsm(bytes32(uint256(1)));