2025-09-19_3个遗传背景多样的小鼠群体.qmd

---
title: 3个小鼠群体
subtitle: 3个遗传背景多样的小鼠群体
date: 2025-09-19
toc-depth: 4
toc-expand: true
lang: en
---

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![图源：bioicons](images/mice.png){width="50%"}
</center>

在2025-09-11，我们提到了协作杂交小鼠群体（Collaborative Cross，简称CC）（[遗传背景多样的协作杂交小鼠群体](2025-09-11_遗传背景多样的协作杂交小鼠群体.qmd)）​​。之后，又看到一篇文献[@RaveslootChavez2025] (这个文章的预印版应该成稿于2023年)[@RaveslootChvez2023]，提到了3种遗传背景多样的小鼠群体，其中包括CC群体。

![](images/elife.png)

## 1. 群体1：CC群体

> The Collaborative Cross (CC) model was founded by 
crossing <mark>five</mark> common laboratory lines and <mark>three</mark> wild-derived lines.

> 协作交叉（Collaborative Cross，简称CC）模型是通过<mark>五</mark>个常见实验室小鼠品系与<mark>三</mark>个野生来源品系进行交叉配种所建立的。

## 2. 群体2：Diversity outbred（DO）群体

> Further breeding of the CC lines created the Diversity Outbred (DO) mouse collection, which is maintained as outbred population through random crossings.

> 通过对协作交叉（CC）品系进一步繁育，建立了多样性远交（Diversity Outbred，简称DO）小鼠资源库，该群体通过随机交配的方式维持为一个远交种群。

## 3. 群体3

> ... a set of 19 new inbred lines derived from wild mice collected ... across 
a latitudinal gradient from Brazil to Canada and show significant phenotypic diversity, including size, body mass index, and lipid and glucose metabolism.

> ……这是一组由从巴西至加拿大的纬度梯度范围内……采集的野生小鼠培育出的19个新建近交系，这些品系展现出<mark>显著的表型多样性</mark>，包括体型、体重指数以及脂质和葡萄糖代谢等方面的差异。

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!["Mice were collected from five different sites across the Americas and inbred to generate individual genetic lines from each location."](images/latitudinal.png){width="60%"}
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> Unlike CC and DO mice, these new lines are all from the Mus musculus domesticus subspecies of house mouse. The use of a single subspecies to establish this cohort is beneficial, as it limits allelic conflicts that can arise from crossing different subspecies.

> <mark>与CC和DO小鼠不同</mark>，这些新建品系均来源于家鼠（house mouse）的*Mus musculus* domesticus亚种。使用单一亚种建立该群体具有重要优势，因为它能有效避免因不同亚种杂交可能引发的等位基因冲突。

[给我买杯茶🍵](给我买杯茶.qmd)

## References