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- **No incidence or excess mortality before age 15**: Minimum age of onset assumption based on expert feedback and literature
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- **No incidence after age 64**: Modeling assumption based on the very low incidence observed at older ages in data from the European Monitoring Centre for Drugs and Drug Addiction
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- **Remission upper limit of 0.2**: Consistent with limits in the dataset
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- **Remission upper limit of 0.2**: Consistent with limits in the DisMod input data
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- **Country-level covariates**:
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- Age-standardized prevalence of intravenous drug use (IDU) for prevalence
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