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Copy file name to clipboardExpand all lines: docs/source/models/concept_models/vivarium_mncnh_portfolio/concept_model.rst
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@@ -341,7 +341,9 @@ Intrapartum component
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.. note::
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Only live births or stillbirths (NOT abortions/miscarriages/ectopic pregnancies) will proceed to the intrapartum component,
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as described above.
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as described above. Both antepartum and intrapartum stillbirths will proceed to the intrapartum component, but not all intrapartum interventions
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will be administered to antepartum stillbirths. Specifically, those with antepartum stillbirths will not be eligible to receive antenatal corticosteroids
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but may still be eligible for misoprostol or azithromycin.
For pregnancies that were determined to result in either a live birth or a stillbirth,
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we choose which of these occurs.
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we choose whether the birth outcome is a live birth, antepartum stillbirth or intrapartum stillbirth.
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Among such pregnancies, the base probability of a live birth is ASFR / (ASFR + ASFR * SBR),
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Among pregnancies that result in births, the base probability of a live birth is ASFR / (ASFR + ASFR * SBR),
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with the remainder being stillbirths.
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This probability is modified by the :ref:`antenatal supplementation intervention <maternal_supplementation_intervention>`.
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Assign timing of stillbirth (stillbirths only)
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~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
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For pregnancies that result in stillbirths, we assign the timing of the stillbirth as either antepartum or intrapartum.
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The probability of intrapartum stillbirth will be affected by the intrapartum sensors -> C-section -> obstructed labor -> intrapartum stillbirth pathway once implemented.
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The timing of stillbirth will affect the eligibility of the simulant dyad for certain intrapartum interventions (i.e., antepartum
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stillbirths will not be eligible for ACS, but intrapartum stillbirths may be).
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The probability of intrapartum stillbirth will be affected by the intrapartum sensors -> C-section -> obstructed labor -> intrapartum stillbirth pathway once implemented,
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but baseline values for rates of antepartum stillbirth rates are outlined in the table below.
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Location-specific probability of intrapartum stillbirth is extracted from a 2018 Lancet Global Health report. [Ahmed_et_al_2018]_
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.. note::
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We assume that live births and stillbirths have the same gestational age. There is ongoing work at IHME to estimate gestational age at birth distributions among stillbirths.
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Additionally, we assume that intrapartum and antepartum stillbirths have the same gestational age distribution. [Madhi_et_al_2019]_ indicates this is likely a reasonable assumption (see Table 2).
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.. note::
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@@ -362,4 +363,9 @@ References
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.. [Ahmed_et_al_2018]
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Ahmed, Imran et al. 2018. Population-based rates, timing, and causes of maternal deaths, stillbirths, and neonatal deaths in south Asia and sub-Saharan Africa: a multi-country prospective cohort study.
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The Lancet Global Health, Volume 6, Issue 12, e1297 - e1308
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The Lancet Global Health, Volume 6, Issue 12, e1297 - e1308
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.. [Madhi_et_al_2019]
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Madhi, Shabir A., et al. 2019. An Observational Pilot Study Evaluating the Utility of Minimally Invasive Tissue Sampling to Determine the Cause of Stillbirths in South African Women.
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Clin Infect Dis. 2019 Oct 9;69(Suppl 4):S342–S350. doi: 10.1093/cid/ciz573
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