diff --git a/kamailio/users/config/kamailio.cfg b/kamailio/users/config/kamailio.cfg
index cc9639a8a3b..8d658323551 100644
--- a/kamailio/users/config/kamailio.cfg
+++ b/kamailio/users/config/kamailio.cfg
@@ -3009,20 +3009,39 @@ route[RTPENGINE_INTERFACES] {
 
     # Direction must be set only in first SDP (initial INVITE with SDP or first response with SDP to initial INVITE with no SDP)
     if ($var(is_from_inside)) {
+        $var(direction_from) = $var(usersAddress);
         if ($dlg_var(externalSocket) != $null) {
             # first response with SDP from AS to initial INVITE with no SDP from UAC
-            $var(interfaces) = "direction=" + $var(usersAddress) + " direction=" + $dlg_var(externalSocket);
+            $var(direction_to) = $dlg_var(externalSocket);
         } else if ($fs != $null) {
             # initial INVITE from AS with SDP
-            $var(branchsockaddr) = $(fs{s.select,1,:});
-            $var(interfaces) = "direction=" + $var(usersAddress) + " direction=" + $var(branchsockaddr);
+            $var(direction_to) = $(fs{s.select,1,:});
         } else {
             xwarn("[$dlg_var(cidhash)] RTPENGINE-INTERFACES: No dlg_var(externalSocket) and fs, this is weird, check!\n");
-            $var(interfaces) = "direction=" + $var(usersAddress) + " direction=" + $var(usersAddress);
+            $var(direction_to) = $var(usersAddress);
         }
     } else {
-        $var(interfaces) = "direction=" + $Ri + " direction=" + $var(usersAddress);
+        $var(direction_from) = $Ri;
+        $var(direction_to) = $var(usersAddress);
+    }
+    ip_type($var(direction_from));
+    $var(direction_from_iptype) = $rc;
+    ip_type($var(direction_to));
+    $var(direction_to_iptype) = $rc;
+    # Direction's IP families are different so set rtpengine correct IP interface according to direction_to_iptype
+    $var(direction_address_family) = "";
+    if( $var(direction_from_iptype) != $var(direction_to_iptype)){
+        switch($var(direction_to_iptype)){
+            case 1:
+                $var(direction_address_family) = "address-family=IP4";
+                break;
+            case 2:
+            case 3:
+                $var(direction_address_family) = "address-family=IP6";
+                break;
+        }
     }
+    $var(interfaces) = "direction=" + $var(direction_from) + " direction=" + $var(direction_to) + " " + $var(direction_address_family);
 }
 
 route[RTPENGINE_UNKNOWN_BYE] {