When I install nix packages using mise with mise-nix, everything is wonderful until I optimize my mac using Mole or CleanMyMac, which sees those mise-nix installations as junk to be deleted.
One can certainly see this as a Mole issue and not a mise-nix issue, but Mole seems to be aware of nix packages installed by nix profile. Maybe because mise-nix doesn't use a nix profile?