22
33# canprot
44
5- Datasets are collected here for differentially (up- and down-)
6- expressed proteins identified in proteomic studies of cancer and in cell
7- culture experiments. Tables of amino acid compositions of proteins are
8- used for calculations of chemical composition, projected into selected
9- basis species. Plotting functions are used to visualize the compositional
10- differences and thermodynamic potentials for proteomic transformations.
5+ Compositional analysis of differentially expressed proteins in cancer and cell
6+ culture proteomics experiments. The data include lists of up- and
7+ down-regulated proteins in different types of cancer (colorectal, pancreatic,
8+ breast, lung, prostate) and laboratory conditions (hypoxia, hyperosmotic
9+ stress, 3D cell culture, and proteins secreted in hypoxia), together with amino
10+ acid compositions calculated for protein sequences from UniProt. Functions are
11+ provided to compute compositional metrics including protein length, carbon
12+ oxidation state, and stoichiometric hydration state. In addition, phylostrata
13+ (evolutionary ages) of protein-coding genes are available using data from
14+ [ Liebeskind et al. (2016)] ( https://doi.org/10.1093/gbe/evw113 ) or [ Trigos et
15+ al. (2017)] ( https://doi.org/10.1073/pnas.1617743114 ) . The vignettes show
16+ references and plots of differences of chemical composition and phylostrata for
17+ all datasets.
1118
1219For more information, see two papers in * PeerJ* ([ 2016] ( http://doi.org/10.7717/peerj.2238 )
1320and [ 2017] ( http://doi.org/10.7717/peerj.3421 ) ).
@@ -23,26 +30,27 @@ install.packages("canprot")
2330
2431## Installation from Github
2532
26- First install the ** devtools ** package from CRAN:
33+ First install the ** remotes ** package from CRAN:
2734
2835``` R
29- install.packages(" devtools " )
36+ install.packages(" remotes " )
3037```
3138
3239Then install ** canprot** from Github:
3340
3441``` R
35- devtools :: install_github(" jedick/canprot" )
42+ remotes :: install_github(" jedick/canprot" )
3643```
3744
38- ## Building vignettes
45+ This also installs the ** CHNOSZ ** and ** xtable ** packages.
3946
40- To install the package including the vignettes:
47+ ### Building vignettes
48+
49+ Building the vignettes requires [ pandoc] ( http://pandoc.org/installing.html ) on the system.
50+ To install the package with the vignettes:
4151
4252``` R
43- devtools :: install_github(" jedick/canprot" , build_vignettes = TRUE )
53+ remotes :: install_github(" jedick/canprot" , dependencies = TRUE , build_vignettes = TRUE )
4454```
4555
46- You may need to re-run this command one or more times. Note that this pulls in
47- more R packages as dependencies, and [ pandoc] ( http://pandoc.org/installing.html )
48- is also required.
56+ This installs more R packages as dependencies (particularly ** knitr** and ** rmarkdown** ).
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