This might be a dupe of issue #24 so please close if appropriate but the issue reads as if it was resolved and I am currently using the melpa package from 20181008.
Emacs version: 25.2.2
latex-preview-pane-mode version: 20181008 melpa
Issue:
Using only one window works but as soon as I open a second window (i.e. C-x 5 2) saving any buffer with active latex-preview-pane-mode causes a new one to open as a vertical split buffer of the original preview window.