Optimizing Anti-Seizure Medication Taper in the EMU

Authors:
Kerry C. Nix*^1,2, Nina J. Ghosn*^2,3, Kevin Xie^2,3, William K. S. Ojemann^2,3, Colin A. Ellis⁴, Genna Waldman⁴, Eli Cornblath⁴, Erin C. Conrad^2,3,4, Brian Litt^2,3,4,5
*These authors contributed equally and share primary authorship

Affiliations:
¹Department of Neuroscience, University of Pennsylvania, Perelman School of Medicine Philadelphia, PA, USA
²Center for Neuroengineering & Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
³Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
⁴Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
⁵Department of Neurosurgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA

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MATLAB code written by Nina J. Ghosn, PhD and Kerry C. Nix.

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Pharmacokinetic models of ASM load:

Ghosn NJ, Xie K, Pattnaik AR, et al. A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit. Epilepsia. 2023;64(5):1236-1247. Doi:10.1111/epi.17558

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Prerequisites

To use this repository, you must have access to Matlab.

Data Availability

Electronic Health Records data is available on Epilepsy.Science.

scripts

This folder contains the main scripts: 

build_data_structs.m Loading and build data structures from electronic health records data, in MATLAB.

analysis_figures.m Run analysis and generate figures, in MATLAB.

core_libraries

This folder contains MATLAB scripts required for running files in "scripts".

Contact Us

Any questions should be directed to the corresponding author. Contact information is provided below: Kerry C. Nix