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A libroadrunner feature is under development (see sys-bio/roadrunner#550) that allows saving and reloading a libroadrunner object. This would let us avoid the slow XML load that currently occurs for every simulation. I've tested a pre-release libroadrunner with this feature, and it is working well.
When this feature is released, PyBNF should use this workflow to gain a significant speedup in SBML fitting.
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enhancementNew feature or requestNew feature or request