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I'm trying the ExtraEffects tools to segment femoral veins in CTAs (arteries great, veins have lower contrast, trying to avoid much manual clean up), couldn't get the control-click to work on Local Threshold, no response on Fast Marching, etc. I found the comment from April '21 by danpak94 at:
https://discourse.slicer.org/t/new-segment-editor-effect-local-threshold/9233/42
and can confirm that while the tools work fine on non-transformed segments, I also have the problem that the tools don't like to work with segmentations that have been transformed (both rotated and translated in my case).
A workable workaround for me is to make a separate, non-transformed segmentation, but that may not be appropriate for everyone.
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