| Item |
Priority |
Effort |
Depends on |
Status |
| Replace synthetic GSE184880 with real TCGA HGSOC cohort |
High |
L |
Data access agreement |
Planned |
| Real EPIC FHIR R4 integration |
High |
L |
Hospital partner |
Planned |
| Multi-patient batch processing |
High |
M |
Refactor patient context |
Planned |
| External patient advocate review of docs/for-patients/ |
High |
S |
Advocate contact |
Planned |
| External HIPAA security audit |
High |
M |
Hospital partner |
Planned |
| Quantum server validation on real circuit hardware (IBM/IonQ) |
Medium |
L |
Cloud account |
Planned |
| scVI/scANVI batch-corrected atlas integration |
Medium |
M |
Single-cell data |
Planned |
| Patient report PDF finalization |
Medium |
S |
Template approval |
Partial |
| Conference submission (AACR or AMIA) |
Medium |
M |
No deadline set |
Partial |
| Educator glossary validation by domain expert |
Medium |
S |
Educator contact |
Planned |
| Add metabolomics server (LC-MS integration) |
Medium |
L |
Metabolomics data |
Planned |
| Federated learning across hospital deployments |
Low |
XL |
Multiple hospital partners |
Planned |
| DICOM/radiology image integration |
Medium |
L |
PACS access |
Planned |
| PAT002 breast cancer validation dataset |
Medium |
M |
Synthetic data generation |
Done |
| Automated CI regression test against canonical values |
Medium |
S |
CI infrastructure |
Planned |
| Multi-language patient report (Spanish, Mandarin) |
Low |
M |
Translation resources |
Planned |
| Cardiometabolic server (lipid panel + CVD risk scoring + Lp(a) + biomarker tracking) |
High |
M |
PAT003 gap report v3 |
Done |
| Cardiovascular polygenic risk score server |
High |
M |
PAT003 data design |
Planned |
| Longitudinal biomarker tracking server |
Medium |
M |
PAT003 use case |
Planned |
| Lifestyle intervention evidence server (literature-based) |
Medium |
L |
PAT003 use case |
Planned |
| Version |
Date |
Summary |
| v17 |
April–May 2026 |
Server #19 cardiometabolic added — Reynolds/Framingham/ASCVD risk scoring, Lp(a), preventive reports; PAT003 live validation (Reynolds 14.3% / Framingham 12.0% / ASCVD 10.3%); PAT002 deep-stage validation — HLA typing, quantum immune evasion, 3 ER+ BC investigational hypotheses (inavolisib, MYC triple therapy, neoepitope vaccine); 6 beyond-SOC hypotheses across 2 cancer types; platform paper v17 submission-ready (Figure 1, Supp S1, Appendix A, SHA-256 manifest); canonical fixtures for PAT001 + PAT002; 19 servers (104 tools) |
| v16 |
April 17, 2026 |
FastMCP 2.x upgrade complete; all servers (see docs/reference/shared/server-registry.md for current count) pass live PAT001 e2e (no DRY_RUN); GEARS perturbation pipeline fully validated; quantum CPU fallback fixed; MHC1 multi-peptide stale variable fixed |
| v15 |
March 27, 2026 |
Initial quantum + GEARS integration; spatial and deconvolution servers added |
(Run git log --oneline to find earlier versions and add them here.)