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Not sure if this is within the scope of the project, but it would be nice to be able to measure along ROIs (e.g. a "profile line" through that moves through space in one (more, eventually?) axis. Through lines, it could be a profile line. With polygons, it could be average intensity (or any other function that takes a set of pixels and returns a number), or a profile line along the circumference of the shape.
Something like this as an example of the profile line:
I worked on something like this a couple of years ago, and might give it a shot when I have the time, but I thought I'd leave this here so I could remember, and if it inspired anyone else to give it a shot since I think it'd be very useful!