As described in https://stackoverflow.com/questions/62327810 and reported to R-devel mailing list, some shiny reactive errors are no longer handled gracefully by generics and the application will crash with:
Warning: Error in <Anonymous>: error in evaluating the argument 'x' in selecting a method for function 'nrow':
[No stack trace available]
As a temporary fix, import of BiocGenerics is avoided starting in DiscoRhythm 1.4.1.
Until the underlying issue can be resolved by changes to R/shiny/DiscoRhythm, any environment with specific generics defined (e.g. nrow) may experience this issue.