diff --git a/CMakeLists.txt b/CMakeLists.txt
index 281b79b399..ca17e61e6d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -21,6 +21,27 @@ project(
   LANGUAGES C CXX
   HOMEPAGE_URL "https://nrn.readthedocs.io/")
 
+# =============================================================================
+# Fixes for Linux wheels
+# =============================================================================
+
+# Force PIE for all executables (idraw, nrniv, etc.) This was the root cause of the original
+# "invalid ELF header: RTLD_GLOBAL" error.
+cmake_policy(SET CMP0083 NEW)
+set(CMAKE_POSITION_INDEPENDENT_CODE
+    ON
+    CACHE BOOL "Force PIE for NEURON + InterViews" FORCE)
+
+# Disable fragile dynamic X11 loading *only* for Linux wheels. This was triggering the (null)
+# RTLD_GLOBAL error. macOS wheels and normal/local Linux builds keep the original default (ON).
+if(SKBUILD
+   AND UNIX
+   AND NOT APPLE)
+  set(IV_ENABLE_X11_DYNAMIC
+      OFF
+      CACHE BOOL "Disable on Linux wheels" FORCE)
+endif()
+
 # =============================================================================
 # CMake common project settings
 # =============================================================================