diff --git a/.github/workflows/weekly-model-system-sync.yml b/.github/workflows/weekly-model-system-sync.yml index e8ef1661..7492bd53 100644 --- a/.github/workflows/weekly-model-system-sync.yml +++ b/.github/workflows/weekly-model-system-sync.yml @@ -36,16 +36,16 @@ jobs: - name: Install dependencies run: | python -m pip install --upgrade pip - pip install synapseclient pyyaml + pip install synapseclient pyyaml pandas - - name: Sync model system data + - name: Sync model system data with conditional filtering run: | - python utils/sync_model_systems.py --synapse-id ${{ env.SYNAPSE_TABLE_ID }} + python utils/sync_model_systems_enhanced.py --synapse-id ${{ env.SYNAPSE_TOOLS_TABLE_ID }} - name: Check for changes id: changes run: | - if [[ $(git status --porcelain modules/Sample/CellLineModel.yaml modules/Sample/AnimalModel.yaml modules/Experiment/Antibody.yaml modules/Experiment/GeneticReagent.yaml) ]]; then + if [[ $(git status --porcelain modules/Sample/CellLineModel.yaml modules/Sample/AnimalModel.yaml modules/Sample/generated/*.yaml modules/Experiment/Antibody.yaml modules/Experiment/GeneticReagent.yaml) ]]; then echo "changes=true" >> $GITHUB_OUTPUT echo "Changes detected in model system and tool files" else @@ -74,38 +74,41 @@ jobs: commit-message: "chore: weekly sync of model system names and tool links from Synapse" title: "Weekly Model System Sync with Tool Links - ${{ steps.date.outputs.date }}" body: | - This PR contains the weekly sync of model system names and tool links from the NFTC truth tables. + This PR contains the weekly sync of model system names and tool links from the NFTC truth tables with conditional enum filtering. **Sources:** - - Model systems: `${{ env.SYNAPSE_TABLE_ID }}` - - Tool links: `${{ env.SYNAPSE_TOOLS_TABLE_ID }}` + - Model systems and tools: `${{ env.SYNAPSE_TOOLS_TABLE_ID }}` **Sync Date:** ${{ steps.date.outputs.date }} ### Changes Made: - Updated cell line models in `modules/Sample/CellLineModel.yaml` - Updated animal models in `modules/Sample/AnimalModel.yaml` + - Generated filtered enum subsets in `modules/Sample/generated/*.yaml` - Updated antibodies in `modules/Experiment/Antibody.yaml` - Updated genetic reagents in `modules/Experiment/GeneticReagent.yaml` - Added/updated `source` links to NF Tools Central detail pages - Rebuilt data model artifacts (`NF.jsonld`, `dist/NF.yaml`) ### Files Modified: - - `modules/Sample/CellLineModel.yaml` - - `modules/Sample/AnimalModel.yaml` + - `modules/Sample/CellLineModel.yaml` (638 cell lines) + - `modules/Sample/AnimalModel.yaml` (123 animal models) + - `modules/Sample/generated/*.yaml` (29 filtered enum subsets) - `modules/Experiment/Antibody.yaml` - `modules/Experiment/GeneticReagent.yaml` - `NF.jsonld` - `dist/NF.yaml` ### What This Includes: - - ✅ Cell line and animal model names from NFTC database (syn26450069) - - ✅ Antibody and genetic reagent resources from NF Tools Central (syn51730943) + - ✅ Cell line and animal model names from NF Tools Central (syn51730943) + - ✅ Filtered enum subsets based on species, category, and genetic disorder (all <100 entries) + - ✅ Antibody and genetic reagent resources from NF Tools Central - ✅ Source links to NF Tools Central detail pages (using `source` field) - ✅ RRID identifiers where available + - ✅ Rich metadata including cellLineCategory and cellLineGeneticDisorder - ✅ Descriptions from database - This sync ensures that the metadata dictionary stays current with the latest cell lines and animal models available in the NFTC research tools database, including proper attribution links. + This sync ensures that the metadata dictionary stays current with the latest cell lines and animal models available in the NFTC research tools database, including proper attribution links and conditional filtering support for the Synapse curator grid. **Automated sync via:** `.github/workflows/weekly-model-system-sync.yml` branch: sync/model-systems-${{ steps.date.outputs.date-short }} diff --git a/.gitignore b/.gitignore index bf228617..155183df 100644 --- a/.gitignore +++ b/.gitignore @@ -35,6 +35,7 @@ __pycache__/ *.py[cod] *$py.class .pytest_cache/ +*_cache.yaml # R / R Studio stuff .Rproj.user/ diff --git a/Makefile b/Makefile index 334dc9f8..960d7ba1 100644 --- a/Makefile +++ b/Makefile @@ -10,7 +10,7 @@ NF.jsonld: NF.yaml: - yq eval-all '. as $$item ireduce ({}; . * $$item )' header.yaml modules/props.yaml modules/**/*.yaml > merged.yaml + yq eval-all '. as $$item ireduce ({}; . *+ $$item )' header.yaml modules/props.yaml modules/**/*.yaml > merged.yaml yq 'del(.. | select(has("annotations")).annotations)' merged.yaml > merged_no_extra_meta.yaml yq 'del(.. | select(has("enum_range")).enum_range)' merged_no_extra_meta.yaml > merged_no_inlined_range.yaml yq 'del(.. | select(has("in_subset")).in_subset)' merged_no_inlined_range.yaml > dist/NF.yaml diff --git a/dist/NF.yaml b/dist/NF.yaml index 1b58a8e7..36748e6b 100644 --- a/dist/NF.yaml +++ b/dist/NF.yaml @@ -1,7 +1,7 @@ -# WARNING: This file is auto-generated from Synapse table syn26450069 +# WARNING: This file is auto-generated from Synapse table syn51730943 # DO NOT EDIT DIRECTLY - changes will be overwritten # For manual entries, use the corresponding *Manual.yaml file -# Generated by utils/sync_model_systems.py +# Generated by utils/sync_model_systems_enhanced.py id: https://w3id.org/nfosi/ default_curi_maps: - semweb_context @@ -784,6 +784,21 @@ slots: range: MultipleImagingDiagnosisEnum required: false title: Meningioma + modelSystemType: + description: Type of model system used in the study (e.g., cell line, animal model, organoid, or patient-derived xenograft). This field helps filter available model system names and is REQUIRED for conditional dropdown filtering. + range: ModelSystemTypeEnum + title: Model System Type + required: true + cellLineCategory: + description: Category of cell line based on origin, disease type, or characteristics. Used to filter cell line options when modelSystemType is 'cell line'. REQUIRED for conditional dropdown filtering when using cell lines. + range: CellLineCategoryEnum + title: Cell Line Category + required: true + cellLineGeneticDisorder: + description: Genetic disorder associated with the cell line (e.g., Neurofibromatosis type 1, NF2, Schwannomatosis). Used as an additional filter for cell lines. REQUIRED for conditional dropdown filtering when using cell lines. + range: CellLineGeneticDisorderEnum + title: Cell Line Genetic Disorder + required: true modelSystemName: any_of: - range: CellLineModel @@ -795,9 +810,9 @@ slots: title: Model System Name required: false modelSpecies: - description: Species of the animal model used (e.g., for xenograft experiments). Distinct from donor species. References species from model in syn51730943. + description: Species of the animal model used (e.g., for xenograft experiments). Distinct from donor species. References species from model in syn51730943. REQUIRED for conditional dropdown filtering. range: SpeciesEnum - required: false + required: true modelSex: any_of: - range: SexEnum @@ -2825,1273 +2840,1273 @@ enums: source: https://pubmed.ncbi.nlm.nih.gov/29286982/ ZetaView: source: https://particle-metrix.com/zetaview/ - AccessTypeEnum: + Data: + description: Type of data represented by the entity (File, Dataset, etc.). notes: - - Historically has been used with `accessTeam` especially if "PRIVATE". - - All files have to qualify to be labeled as such, e.g. a single Controlled Access file will make the dataset Controlled Access. - - This is not personalized to the user. They will have to evaluate it from their perspective, we are not dynamically rendering this. - - See also https://github.com/PAIR-code/datacardsplaybook/blob/main/templates/DataCardsExtendedTemplate.md#access-type - permissible_values: - Controlled Access: - description: 'Access is restricted and only available after fulfilling specific requirements, such as submitting a research statement or getting approval directly from the data owner through Synapse. Note that for datasets, if any component file is under controlled access, the entire dataset is considered to be under controlled access.' - Open Access: - description: Access without any additional steps/requirements without even needing to be logged in to Synapse account. - Private Access: - description: Not accessible outside the project admins and study team -- check whether you are on an access team or contact the PI/admin of access team to request access. - Public Access: - description: Access without any additional steps/requirements as long as you are logged in to Synapse. - title: Access type - DataCatalogEnum: - permissible_values: - https://www.synapse.org/DataCatalog:0: - https://nf.synapse.org/Explore/Datasets: - DataSeriesEnum: - permissible_values: - NF-OSI Processed Data: - None: - DataStatusEnum: + - http://edamontology.org/data_0006 + - Broad term/abstract class; should not be used for annotation permissible_values: - Available: - description: Data is fully available for download for the project (with fulfillment of any governance requirements). - Data Not Expected: - description: Data is not expected for the project. - Data Pending: - description: There is no data yet in the project because it is still being generated or has not yet been uploaded yet. - Partially Available: - description: Some data is available for download for the project. - Rolling Release: - description: This project has an ongoing cycle of incoming data that is released in batches. - Under Embargo: - description: Data is present in the project but not accessible to anyone outside the project admins and study team. + aligned reads: + description: Aligned reads output from alignment workflows + source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=aligned_reads + annotated germline variants: + description: Germline variants annotated with some annotation workflow + source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=annotated_germline_variation + annotated somatic mutation: + description: Somatic variants annotated with some annotation workflow + source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=annotated_somatic_mutation + audio transcript: + description: Text transcript of an audio recording. + source: https://w3id.org/synapse/nfosi/vocab/audioTranscript + behavioral data: + description: "Qualitative or quantitative behavioral measurements / observations about the action, reaction, or performance of an organism in response to external or internal stimuli. \nExamples: avoidance behavior, choice-making.\n" notes: - - When data is first uploaded, the status should change from “Data Pending” to “Under Embargo”. - title: Data Status - DiseaseFocusEnum: - permissible_values: - 22q-related schwannomatosis: - LZTR1-related schwannomatosis: - Multiple: - NF2-related schwannomatosis: - Neurofibromatosis type 1: - SMARCB1-related schwannomatosis: - Schwannomatosis-NEC: - Schwannomatosis-NOS: - title: Disease Focus - DuoEnum: - permissible_values: - Clinical Care Use: - description: Clinical Care Use - Collaboration Required: - description: Collaboration Required - PI Contact information required - Disease Specific Research: - description: Disease Specific Research - Provide detail [DOID] or [MONDO] - Ethics Approval Required: - description: Ethics Approval Required - User prompted to provide IRB/IEC approval - General Research Use: - description: General Research Use - Genetic Studies Only: - description: Genetic Studies Only - Geographical Restriction: - description: Geographical Restriction - Provide country restriction [ISO 3166⍺2] - Health or Medical or Biomedical Research: - description: Health or Medical or Biomedical Research - Institution Specific Restriction: - description: Institution Specific Restriction - Name Institution [ror.org] - No General Methods Research: - description: No General Methods Research - No Restriction: - description: No Restriction - Data is available under Open or Anonymous access - Non-Commercial Use Only: - description: Non-Commercial Use Only - Not-for-Profit Non-Commercial Use Only: - description: Not-for-Profit, Non-Commercial Use Only - Not-for-Profit Organisation Use Only: - description: Not-for-Profit Organisation Use Only - Population Origins or Ancestry Research Only: - description: Population Origins or Ancestry Research Only - User must describe research use in IDU statement - Population Origins or Ancestry Research Prohibited: - description: Population Origins or Ancestry Research Prohibited - Project Specific Restriction: - description: Project Specific Restriction - User prompted to provide IDU statement - Publication Moratorium: - description: Publication Moratorium - Provide date [ISO 8601] - Publication Required: - description: Publication Required - Research Specific Restrictions: - description: Research Specific Restrictions - Provide detail - Return to Database or Resource: - description: Return to Database or Resource - Time Limit on Use: - description: Time Limit on Use - Provide date [ISO 8601] - User Specific Restriction: - description: User Specific Restriction - User may be required to register, enhance their profile, join a Synapse Team, or have a specific authentication, e.g., 2FA or RAS - title: Data Use Modifiers - FundingAgencyEnum: - permissible_values: - CTF: - GFF: - Independent: - NIH-NCI: - NTAP: - Other: - License: - description: License attached to the data. If indicates UNKNOWN or RESTRICTED-USE, data may not be used without further contact for terms. - notes: - - https://libanswers.ucalgary.ca/faq/200582 - - https://resources.data.gov/open-licenses/ - - https://the-turing-way.netlify.app/reproducible-research/licensing/licensing-data.html - - https://help.figshare.com/article/what-is-the-most-appropriate-licence-for-my-research - permissible_values: - CC BY-NC: - aliases: - - cc-by-nc - description: 'This license is one of the Creative Commons licenses and allows users to share and adapt the dataset if they give credit to the copyright holder and do not use the dataset for any commercial purposes.' - source: https://creativecommons.org/licenses/by-nc/4.0/ - title: Creative Commons Attribution-NonCommercial 4.0 International - CC BY-NC 4.0: - aliases: - - cc-by-nc-4.0 - - cc by-nc 4.0 - meaning: https://creativecommons.org/licenses/by-nc/4.0/ - CC BY-NC 3.0: + - Legacy concept previously labeled "behavior process", updated to "behavioral data". + capsid sequence: + description: Sequence of capsid protein regions (AAV9, AAVsc, etc.) + meaning: EDAM:data_3494 + notes: + - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. + cellular physiology: + description: Data on the physiological parameter of a cell. + source: https://w3id.org/synapse/nfosi/vocab/cellularPhysiology + characteristic: aliases: - - cc-by-nc-3.0 - meaning: https://creativecommons.org/licenses/by-nc/3.0/ - CC BY-NC 2.5: + - Feature + - Nature + description: Broad data type for data that can encompass volume, weight, brightness, color, capacity, etc. + meaning: NCIT:C25447 + notes: + - Not preferred for annotation; more specific term should be used. + - May cover both morphology parameter and physiology parameter. + chromatin activity: + description: Data of chromatin activity, which allows access to condensed genomic DNA and potentially controls gene expression. + see_also: + - https://en.wikipedia.org/wiki/Chromatin_remodeling + source: https://w3id.org/synapse/nfosi/vocab/chromatinActivity + clinical: + description: Data containing clinical information, e.g. patient diagnosis, personal demographics, exposures, laboratory tests, family relationships. + meaning: EFO:0030083 + notes: + - The closest EDAM term is for [EHR](http://edamontology.org/data_3861), and while [ecological data](http://edamontology.org/data_3736), there is no mapping, which is why we use EFO. + see_also: + - https://docs.gdc.cancer.gov/Encyclopedia/pages/Clinical_Data + copy number variants: + description: Copy number variants + source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=copy_number_variation + count matrix: aliases: - - cc-by-nc-2.5 - meaning: https://creativecommons.org/licenses/by-nc/2.5/ - CC BY-NC 2.0: + - Read count matrix + description: A table of unnormalized values representing summarised read counts per genomic region (e.g. gene, transcript, peak). + meaning: EDAM:data_3917 + data index: + description: A data index is information used to help with retrieval of some other data, especially large-scale data that would benefit from such an index. Very common formats are .bai and .tbi. + meaning: EDAM:data_0955 + data sharing plan: aliases: - - cc-by-nc-2.0 - meaning: https://creativecommons.org/licenses/by-nc/2.0/ - CC BY-NC 1.0: + - DMP + - Data Management Plan + - Data Landscape Survey + description: A document containing the plan and documentation for data sharing, one component of overall data management. + meaning: EDAM:data_4040 + notes: + - Technically EDAM term is 'data management plan', which is more encompassing in scope. + - Use for tagging uploaded data sharing plans. + demographics: aliases: - - cc-by-nc-1.0 - meaning: https://creativecommons.org/licenses/by-nc/1.0/ - CC BY-NC-ND: + - Demographic Factor + - Demography + - Population Studies / Demography + description: The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income). + meaning: NCIT:C16495 + drug combination screen: + description: Information on drug sensitivity of more than one compound + source: https://www.ncbi.nlm.nih.gov/pubmed/29344898 + drug screen: + description: Information on drug sensitivity and molecular markers of drug response + source: https://w3id.org/synapse/nfosi/vocab/drugScreen + electrophysiology: + description: "Data generated from an electrophysiology assay, e.g: \n- Cell: Resting membrane potential, ion channel currents (patch clamp data)\n- Neurons: Action potentials, resting potential, synaptic potentials. \n- Heart: Electrocardiogram (ECG/EKG) waveforms, cardiac action potentials.\n- Muscle: Electromyogram (EMG) signals\n- Whole brain: Electroencephalogram (EEG)\n- Retina: Electroretinogram (ERG)\n" + notes: + - ERO has been deprecated and direct URIs no longer work. + source: https://bioportal.bioontology.org/ontologies/ERO/?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FERO_0000564&jump_to_nav=true + epidemiological data: + description: Data that is used to describe the distribution of a disease or health-related characteristic within a population and to identify factors that affect that distribution. + gene expression: + description: Data of the levels and patterns of synthesis of gene products (proteins and functional RNA), including interpretation in functional terms of gene expression data. + meaning: EDAM:data_2603 + notes: + - EDAM does have a broader mapping, [expression data](http://edamontology.org/data_2603) + - The mapping used maps to [gene expression profile](http://edamontology.org/data_0928) + - Covers both raw (e.g. fastqs, microarray intensities) and processed gene expression data (e.g. normalized gene expression matrix). + gene expression matrix: aliases: - - cc-by-nc-nd - description: 'This license is one of the Creative Commons licenses and allows users to use only your unmodified dataset if they give credit to the copyright holder and do not share it for commercial purposes. Users cannot make any additions, transformations or changes to the dataset under this license.' - source: https://creativecommons.org/licenses/by-nc-nd/4.0/ - title: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International - CC BY-NC-ND 4.0: + - Gene expression data matrix + - Normalised microarray data + description: The final processed (normalised) data for a set of hybridisations in a microarray experiment. This combines data from all hybridisations. + meaning: EDAM:data_3112 + quantified gene expression: + description: Expression measurements that have been summarized or normalized, typically representing quantified abundance metrics rather than raw instrument output. + genomic features: + description: Data of sequence feature (continuous extent of biological sequence) that is of genomic origin. + meaning: GENO:0000481 + notes: + - Really subclass of "nucleic acid features" (http://edamontology.org/data_1276) + see_also: https://en.wikipedia.org/wiki/General_feature_format + genomic variants: aliases: - - cc-by-nc-nd-4.0 - meaning: https://creativecommons.org/licenses/by-nc-nd/4.0/ - CC BY-NC-ND 3.0: - aliases: - - cc-by-nc-nd-3.0 - meaning: https://creativecommons.org/licenses/by-nc-nd/3.0/ - CC BY-NC-ND 2.5: - aliases: - - cc-by-nc-nd-2.5 - meaning: https://creativecommons.org/licenses/by-nc-nd/2.5/ - CC BY-NC-ND 2.0: - aliases: - - cc-by-nc-nd-2.0 - meaning: https://creativecommons.org/licenses/by-nc-nd/2.0/ - CC BY-NC-ND 1.0: + - Gene sequence variations + description: 'Genomic alterations, including single nucleotide polymorphisms, short indels and structural variants. Use more specific term if possible, esp. if data is only of one specific subset. + +' + meaning: EDAM:data_3498 + notes: + - Somewhat more specific than the concept URI it is mapped to. + germline variants: + description: Called germline variants + source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=simple_germline_variation + guide RNA sequence: aliases: - - cc-by-nc-nd-1.0 - meaning: https://creativecommons.org/licenses/by-nc-nd/1.0/ - CC BY-NC-SA: + - sgRNA sequence + - gRNA sequence + description: Sequence data for guide RNAs used in CRISPR or other gene editing experiments. + meaning: EDAM:data_3494 + notes: + - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. + image: aliases: - - cc-by-nc-sa - description: 'This license is one of the Creative Commons licenses and allows users to share the dataset only if they (1) give credit to the copyright holder, (2) do not use the dataset for any commercial purposes, and (3) distribute any additions, transformations or changes to the dataset under this same license.' - source: https://creativecommons.org/licenses/by-nc-sa/4.0/ - title: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International - CC BY-NC-SA 4.0: + - Image data + description: Biological or biomedical data that has been rendered into an image. + meaning: EDAM:data_2968 + immunoassay: aliases: - - cc-by-nc-sa-4.0 - meaning: https://creativecommons.org/licenses/by-nc-sa/4.0/ - CC BY-NC-SA 3.0: + - Immunological Laboratory Method + - Immunology Test + description: Laboratory test involving interaction of antigens with specific antibodies. + meaning: NCIT:C16723 + isoform expression: aliases: - - cc-by-nc-sa-3.0 - meaning: https://creativecommons.org/licenses/by-nc-sa/3.0/ - CC BY-NC-SA 2.5: + - Isoform Measurement + - Isoform Quantitation + - Protein Isoform Measurement + - Protein Isoform Quantitation + description: Expression of protein isoforms formed from alternative splicings or other post-translational modifications of a single gene through RNA splicing mechanisms. + meaning: NCIT:C184767 + source: https://en.wikipedia.org/wiki/Protein_isoform + kinomics: + description: Data studying protein kinase signaling/activity. + notes: + - See "Kinome Response Profile" (http://purl.obolibrary.org/obo/NCIT_C107137) for kinome data *specifically* with drug treatment + - Subclasss of "Proteomics" (http://purl.obolibrary.org/obo/NCIT_C16723) + source: https://w3id.org/synapse/nfosi/vocab/kinomics + mask image: + description: Image used as the mask for an image processing operation, such as subtraction. + meaning: DCM:121321 + mass spectrometry data: + description: Data from mass spectrometry measurement. + meaning: EDAM:data_2536 + metabolomics: + description: Data of metabolites, the chemical processes they are involved, and the chemical fingerprints of specific cellular processes in a whole cell, tissue, organ or organism. + see_also: + - http://edamontology.org/topic_3172 + source: https://w3id.org/synapse/nfosi/vocab/metabolomics + molecular property: aliases: - - cc-by-nc-sa-2.5 - meaning: https://creativecommons.org/licenses/by-nc-sa/2.5/ - CC BY-NC-SA 2.0: + - Physicochemical property + description: Data on the physical (e.g. structural) or chemical properties of molecules, or parts of a molecule. + meaning: EDAM:data_2087 + morphology parameter: + description: Experimentally determined parameter of the morphology of an organism, e.g. size & shape. General term representing data about **structure** and **form** of an organism or organism part. + meaning: EDAM:data_3723 + network: aliases: - - cc-by-nc-sa-2.0 - meaning: https://creativecommons.org/licenses/by-nc-sa/2.0/ - CC BY-NC-SA 1.0: + - Pathway + description: Network data represents connections between entities and are often in graphical format. + meaning: EDAM:data_2600 + notes: + - EDAM preferred label is 'Pathway or network' + nucleic acid sequence record: aliases: - - cc-by-nc-sa-1.0 - meaning: https://creativecommons.org/licenses/by-nc-sa/1.0/ - CC BY-ND: + - Nucleotide sequence record + - Sequence record (nucleic acid) + description: A nucleic acid sequence and associated metadata. + meaning: EDAM:data_2887 + notes: + - Can be used for .dna (SnapGene) files. + over-representation data: aliases: - - cc-by-nd - description: 'This license is one of the Creative Commons licenses and allows users to share the dataset if they give credit to copyright holder, but they cannot make any additions, transformations or changes to the dataset under this license.' - source: https://creativecommons.org/licenses/by-nd/4.0/ - title: Creative Commons Attribution-NoDerivatives 4.0 International - CC BY-ND 4.0: + - Enrichment report + - Over-representation report + description: A ranked list of categories (usually ontology concepts), each associated with a statistical metric of over-/under-representation within the studied data. + meaning: EDAM:data_3753 + particle characterization: + description: Data providing information about entities such as composition, structure and defects. + meaning: NCIT:C62317 + notes: + - More general than `molecular property` + pharmacokinetics: aliases: - - cc-by-nd-4.0 - meaning: https://creativecommons.org/licenses/by-nd/4.0/ - CC BY-ND 3.0: + - PK Study + - Pharmacokinetic Study + description: Data characterizing the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body. + meaning: NCIT:C49663 + physiology parameter: + description: Experimentally determined parameter of the physiology of an organism, e.g. metabolic rate. General term representing data about **function** and **process** of an organism or organism part. + meaning: EDAM:data_3722 + notes: + - Relation to pharmacokinetic data -- certain physiology parameteres inherent to the organism influences its pharmokinetics of a drug. + plasmid sequence: + description: Sequence data for plasmid vectors used in cloning or gene expression experiments. + meaning: EDAM:data_3494 + notes: + - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. + plot: aliases: - - cc-by-nd-3.0 - meaning: https://creativecommons.org/licenses/by-nd/3.0/ - CC BY-ND 2.5: + - Graph data + description: Data that has been plotted as a graph of some type, or data representing such a graph. + meaning: EDAM:data_2884 + primer sequence: + description: Sequence data for oligonucleotide primers used in PCR or sequencing experiments. + meaning: EDAM:data_3494 + notes: + - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. + probe sequence: + description: Sequence data for nucleic acid probes used in hybridization experiments. + meaning: EDAM:data_3494 + notes: + - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. + promoter sequence: + description: Sequence data of promoter region (P0, flCAG, etc.) + meaning: EDAM:data_3494 + notes: + - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. + protein interaction data: aliases: - - cc-by-nd-2.5 - meaning: https://creativecommons.org/licenses/by-nd/2.5/ - CC BY-ND 2.0: + - Protein interaction record + - Protein report (interaction) + - Protein-protein interaction data + description: 'Data concerning the interactions (predicted or known) within or between a protein, structural domain or part of a protein. This includes intra- and inter-residue contacts and distances, as well as interactions with other proteins and non-protein entities such as nucleic acid, metal atoms, water, ions etc. + +' + meaning: EDAM:data_0906 + protein interaction raw data: + description: Protein-protein interaction data from for example yeast two-hybrid analysis, protein microarrays, immunoaffinity chromatography followed by mass spectrometry, phage display etc. + meaning: EDAM:data_0905 + proteomics: + description: Protein and peptide identification, especially in the study of whole proteomes of organisms. + meaning: EDAM:topic_0121 + raw counts: aliases: - - cc-by-nd-2.0 - meaning: https://creativecommons.org/licenses/by-nd/2.0/ - CC BY-ND 1.0: + - Count + - NUMBER + - Num + - Number Count + description: The number or amount of something. + meaning: NCIT:C25463 + reference sequence: + description: Generic sequence data used as a reference in experimental design or analysis. + meaning: EDAM:data_3494 + notes: + - Use more specific sequence type if applicable (e.g., primer sequence, plasmid sequence). + report: aliases: - - cc-by-nd-1.0 - meaning: https://creativecommons.org/licenses/by-nd/1.0/ - CC BY-SA: + - Document + - Record + description: A human-readable collection of information including annotation on a biological entity or phenomena, computer-generated reports of analysis of primary data... as distinct from the primary data itself. + meaning: EDAM:data_2048 + somatic variants: + description: Called somatic variants + source: https://w3id.org/synapse/nfosi/vocab/SomaticVariants + structural variants: + description: Genomic variants data that covers deletions, duplications, CNVs, insertions, inversions, and translocations, which may be derived from specialized variant calling workflows. + source: https://w3id.org/synapse/nfosi/vocab/StructuralVariantss + survey data: + description: A data set that contains the outcome of a survey. + meaning: OMIABIS:0000060 + text data: + description: Data that is represented as text, usually referring to "unstructured data". + meaning: EDAM:data_2526 + volume: aliases: - - cc-by-sa - description: 'This license is one of the open Creative Commons licenses and allows users to share and adapt the dataset as long as they give credit to the copyright holder and distribute any additions, transformations or changes to the dataset under this same https://creativecommons.org/licenses/by/4.0/' - source: https://creativecommons.org/licenses/by-nc-sa/4.0/ - title: Creative Commons Attribution-ShareAlike 4.0 International - CC BY-SA 4.0: + - Total Volume + - Vol + description: Data of the three dimensional space occupied by an entity or the capacity of a space or container. + meaning: NCIT:C25335 + weight: + description: The vertical force exerted by a mass as a result of gravity. + meaning: NCIT:C25208 + DataSubtypeEnum: + description: 'Categorizes data based on its processing state. This is the main classification axis used for data types. Not all data types can use this dimensions (e.g. clinical data). + +' + permissible_values: + derived: + description: Data from additional analytical steps performed on already processed data. + normalized: + description: Data that has undergone a normalization procedure to adjust for technical variation or to bring measurements onto a common scale. Considered a more specific type of processed data. + meaning: OBI:0000451 + processed: + description: Data generated from running one or more bioinformatics methods on raw data. + quantified: + description: Data representing measurements/counts of specific features (gene counts, peak intensities, object properties). + raw: + description: Data produced by experimental measurement/observation with very little subsequent processing. + synthetic: + description: Data generated computationally via models or simulations, not direct experimental measurement. + MetadataEnum: + description: Data that provides information about other data + permissible_values: + descriptive metadata: + description: Information that describes and identifies a resource, including elements that facilitate discovery and understanding. + notes: + - Currently used for `manifest.csv` files. + image metadata: aliases: - - cc-by-sa-4.0 - meaning: https://creativecommons.org/licenses/by-sa/4.0/ - CC BY-SA 3.0: - aliases: - - cc-by-sa-3.0 - meaning: https://creativecommons.org/licenses/by-sa/3.0/ - CC BY-SA 2.5: - aliases: - - cc-by-sa-2.5 - meaning: https://creativecommons.org/licenses/by-sa/2.5/ - CC BY-SA 2.0: - aliases: - - cc-by-sa-2.0 - meaning: https://creativecommons.org/licenses/by-sa/2.0/ - CC BY-SA 1.0: - aliases: - - cc-by-sa-1.0 - meaning: https://creativecommons.org/licenses/by-sa/1.0/ - CC-0: + - Image-associated data + - Image-related data + description: Data concerning a specific biological or biomedical image. + meaning: EDAM:data_3546 + notes: + - For e.g. XML files that contain image metadata. + metadata: + description: Most general label for data that contains information about data. + workflow metadata: + comments: Coined category for use esp. with nextflow metadata files. + description: Process data from computational workflows. This is highly related to Statistical Metadata. Basic information, annotation or documentation concerning a workflow (but not the workflow itself). + meaning: EDAM:data_0949 + source: https://en.wikipedia.org/wiki/Metadata + NotApplicableEnum: + permissible_values: + Not Applicable: + description: Not applicable in this context + UnknownEnum: + permissible_values: + Unknown: aliases: - - cc0 - - cc-zero - - cc-by-+-cc0 - description: A Creative Commons license and is like a public domain dedication. The copyright holder surrenders rights in a dataset using this license. - source: https://creativecommons.org/publicdomain/zero/1.0/ - title: Creative Commons Zero - CC0 1.0: + - Not Known + - U + - UNK + - Unknown/Not Stated + description: Not known, observed, recorded; or reported as unknown by the data contributor. + meaning: NCIT:C17998 + SequencingFileFormatEnum: + description: File formats for sequencing data including alignments, variants, and genomic annotations + title: Sequencing File Format + permissible_values: + bai: + description: BAM indexing format + meaning: EDAM:format_3327 + bam: + description: BAM format, the binary, BGZF-formatted compressed version of SAM format for alignment of nucleotide sequences (e.g. sequencing reads) to (a) reference sequence(s) + meaning: EDAM:format_2572 + bcf: + description: BCF, the binary version of Variant Call Format (VCF) for sequence variation (indels, polymorphisms, structural variation) + meaning: EDAM:format_3016 + bed: + description: Browser Extensible Data (BED) format of sequence annotation track, typically to be displayed in a genome browser + meaning: EDAM:format_3003 + bed broadPeak: + description: This format is used to provide called regions of signal enrichment based on pooled, normalized (interpreted) data. It is a BED 6+3 format. + source: http://genome.ucsc.edu/FAQ/FAQformat.html#format13 + bed gappedPeak: + description: This format is used to provide called regions of signal enrichment based on pooled, normalized (interpreted) data where the regions may be spliced or incorporate gaps in the genomic sequence. It is a BED12+3 format. + source: http://genome.ucsc.edu/FAQ/FAQformat.html#format14 + bed narrowPeak: + description: This format is used to provide called peaks of signal enrichment based on pooled, normalized (interpreted) data. It is a BED6+4 format. + source: http://genome.ucsc.edu/FAQ/FAQformat.html#format12 + bedgraph: + description: Holds a tab-delimited chromosome /start /end / datavalue dataset. The bedGraph format allows display of continuous-valued data in track format. This display type is useful for probability scores and transcriptome data + meaning: EDAM:format_3583 + bgzip: + description: Blocked GNU Zip format + meaning: EDAM:format_3615 + bigwig: + description: bigWig format for large sequence annotation tracks that consist of a value for each sequence position + meaning: EDAM:format_3006 + cnn: + description: Copy number reference profile from CNVKit pipeline. + source: https://cnvkit.readthedocs.io/en/stable/fileformats.html + cnr: + description: Copy number ratios from CNVKit pipeline, storing each bin's proportional weight or reliability. + source: https://cnvkit.readthedocs.io/en/stable/fileformats.html + cns: + description: Segmented log2 ratios from CNVKit pipeline, these represent the most relevant output describing copy number variation. + source: https://cnvkit.readthedocs.io/en/stable/fileformats.html + crai: + description: A CRAI file is an index for a CRAM file, facilitating fast data retrieval. + notes: + - ChatGPT (September 25, 2023 Version) + cram: + description: A CRAM file is a compressed format for storing genomic sequence data. + meaning: EDAM:format_3462 + notes: + - ChatGPT (September 25, 2023 Version) + csi: + description: A CSI file is a compressed sequence index used for efficiently accessing genomic data in large datasets. + notes: + - ChatGPT (September 25, 2023 Version) + ctab: + description: Gene expression counts file and a specific format of .tsv commonly part of bioinformatics workflows (Stringtie and Ballgown). + source: https://github.com/alyssafrazee/ballgown#ballgown-readable-expression-output + dup: + description: output of the Picard MarkDuplicates tool. + source: https://software.broadinstitute.org/gatk/documentation/tooldocs/4.0.4.0/picard_sam_markduplicates_MarkDuplicates.php + fasta: aliases: - - cc0-1.0 - meaning: https://creativecommons.org/publicdomain/zero/1.0/ - CC-BY: + - FASTA format + - FASTA sequence format + description: FASTA format is a text-based format for representing either nucleotide sequences or peptide sequences, in which nucleotides or amino acids are represented using single-letter codes + meaning: EDAM:format_1929 + fastq: aliases: - - cc-by - description: This license is one of the open Creative Commons licenses and allows users to share and adapt the dataset so long as they give credit to the copyright holder. - source: https://creativecommons.org/licenses/by/4.0/ - title: Creative Commons Attribution 4.0 International - CC-BY 4.0: + - fq + description: FASTQ format is a text-based format for storing both a biological sequence (usually nucleotide sequence) and its corresponding quality scores. Both the sequence letter and quality score are each encoded with a single ASCII character for brevity + meaning: EDAM:format_1930 + flagstat: + description: Output of samtools flagstat tool + gct: aliases: - - cc-by-4.0 - - cc by 4.0 - meaning: https://creativecommons.org/licenses/by/4.0/ - CC-BY 3.0: + - GCT format + - Res format + description: Tab-delimited text files of GenePattern that contain a column for each sample, a row for each gene, and an expression value for each gene in each sample + meaning: EDAM:format_3709 + gff3: + description: Generic Feature Format version 3 (GFF3) of sequence features. + meaning: EDAM:format_1975 + gtf: + description: Gene transfer format (GTF) is a file format used to hold information about gene structure + meaning: EDAM:format_2306 + source: https://en.wikipedia.org/wiki/Gene_transfer_format + hic: + description: Hi-C contact matrix file + source: https://github.com/theaidenlab/juicer/wiki/Data + maf: + description: Mutation annotation format as outputted from GenomeNexus. + notes: + - DO NOT use http://edamontology.org/format_3008 as that refers to Multiple Alignment Format (MAF). + source: https://docs.gdc.cancer.gov/Data/File_Formats/MAF_Format + mtx: + description: Matrix Market Exchange Format + meaning: EDAM:format_3916 + source: https://math.nist.gov/MatrixMarket/formats.html#MMformat + plink: + description: Any Plink file format (MAP/PED/BED/BIM/FAM) + source: https://www.cog-genomics.org/plink2/formats + recal: + description: .recal file from GATK VQSR + source: https://software.broadinstitute.org/gatk/documentation/tooldocs/3.8-0/org_broadinstitute_gatk_tools_walkers_variantrecalibration_VariantRecalibrator.php#--recal_file + sam: + description: Sequence Alignment/Map (SAM) format for alignment of nucleotide sequences (e.g. sequencing reads) to (a) reference sequence(s) + meaning: EDAM:format_2573 + seg: + description: SEG file (segmented data; .seg or .cbs) is a tab-delimited text file that lists loci and associated numeric values + source: https://software.broadinstitute.org/software/igv/SEG + sf: + description: Salmon's main output is its quantification file. This file is a plain-text, tab-separated file with a single header line (which names all of the columns). + source: https://salmon.readthedocs.io/en/latest/file_formats.html + sra: aliases: - - cc-by-3.0 - meaning: https://creativecommons.org/licenses/by/3.0/ - CC-BY 2.5: + - SRA archive format + description: SRA archive format (SRA) is the archive format used for input to the NCBI Sequence Read Archive. + meaning: EDAM:format_3698 + tagAlign: + description: Tag Alignment provides genomic mapping of short sequence tags. + source: https://genome.ucsc.edu/FAQ/FAQformat.html#format15 + tbi: aliases: - - cc-by-2.5 - meaning: https://creativecommons.org/licenses/by/2.5/ - CC-BY 2.0: + - TBI Format + - Tabix + description: A TBI file is an index for a TABIX-compressed genomic data file, enabling rapid region-based retrieval. + meaning: NCIT:C184806 + tranches: + description: .tranches file from GATK VQSR + source: https://software.broadinstitute.org/gatk/documentation/tooldocs/3.8-0/org_broadinstitute_gatk_tools_walkers_variantrecalibration_VariantRecalibrator.php#--tranches_file + vcf: + description: Variant Call Format (VCF) for sequence variation (indels, polymorphisms, structural variation) + meaning: EDAM:format_3016 + wiggle: + description: Wiggle format (WIG) of a sequence annotation track that consists of a value for each sequence position + meaning: EDAM:format_3005 + ImagingFileFormatEnum: + description: File formats for imaging data including medical imaging and microscopy + title: Imaging File Format + permissible_values: + DICOM: + description: A comprehensive set of standards for communications between medical imaging devices, including handling, storing and transmitting information in medical imaging. It includes a file format definition and a network communication protocol. + meaning: EDAM:format_3548 + NWB: + description: Neurodata Without Borders (NWB) is a data standard for neurophysiology data, designed to store data including from intracellular and extracellular electrophysiology experiments, data from optical physiology experiments, and tracking and stimulus data. + source: https://www.nwb.org/ + PAR: + description: This is yet another MRI image format generated by Philips scanners. It is an ASCII header (PAR) plus a binary blob (REC). + source: https://nipy.org/nibabel/reference/nibabel.parrec.html + REC: + description: This is yet another MRI image format generated by Philips scanners. It is an ASCII header (PAR) plus a binary blob (REC). + source: https://nipy.org/nibabel/reference/nibabel.parrec.html + aci: + description: Leica image archive format - UTF-8 encoded microscopy data format used by Leica Confocal Software systems. + source: https://filext.com/file-extension/ACI + avi: aliases: - - cc-by-2.0 - meaning: https://creativecommons.org/licenses/by/2.0/ - CC-BY 1.0: + - Audio Video Interleaved + description: AVI files can contain both audio and video data in a file container that allows synchronous audio-with-video playback. + meaning: EDAM:format_3990 + source: https://en.wikipedia.org/wiki/Audio_Video_Interleave + bmp: + description: Bitmap image format. + meaning: EDAM:format_3592 + czi: + description: Microscopy imaging file format that saves multidimensional images such as time lapse, Z-stacks, multiposition experiments and virtual slides, combined with relevant meta information + source: https://www.zeiss.com/microscopy/int/products/microscope-software/zen/czi.html + hdr: + description: MRI Header file, as in the NIFTI-1 Analyze 7.5 format + source: https://nifti.nimh.nih.gov/pub/dist/src/niftilib/nifti1.h + img: + description: MRI Data file, as in the NIFTI-1 Analyze 7.5 format + source: https://nifti.nimh.nih.gov/pub/dist/src/niftilib/nifti1.h + jpg: aliases: - - cc-by-1.0 - meaning: https://creativecommons.org/licenses/by/1.0/ - ODC-BY: + - JPEG + description: Joint Picture Group file format for lossy graphics file. + meaning: EDAM:format_3579 + lif: + description: Leica Image Format (LIF) images are JPEG images with metadata that may contain depth, bokeh data, and one or more images (e.g. stereo images) known as "views". + source: https://docs.openmicroscopy.org/bio-formats/5.8.2/formats/leica-lif.html + mov: + description: A video file format with the .mov extension + source: https://synapse.org + nii: aliases: - - odc-by - description: This license is one of the Open Data Commons licenses and allows users to share and adapt the dataset as long as they give credit to the copyright holder. - source: https://opendatacommons.org/licenses/by/ - title: Open Data Commons Attribution License - ODC-BY 1.0: - aliases: - - odc-by-1.0 - meaning: https://opendatacommons.org/licenses/by/1-0/ - ODC-ODbL: + - NIFTI format + description: NIfTI-1 can store image data from any modality such as PET, MRI, CT, EEG that produces regularly sampled 1-5D rasters. + meaning: EDAM:format_3549 + source: https://nifti.nimh.nih.gov/nifti-1/documentation/faq + ome-tiff: + description: OME-TIFF is a preferred open image format + meaning: EDAM:format_3727 + png: + description: PNG is a file format for image compression + meaning: EDAM:format_3603 + svs: + description: A single-file pyramidal tiled TIFF, with non-standard metadata and compression. + source: https://openslide.org/formats/aperio/ + sws: + description: Surveyor Workspace format - a tiled microscopy image format from Objective Imaging systems comprising folders with high-resolution image tiles, thumbnails, metadata files, and a .sws file. + source: https://objectiveimaging.freshdesk.com/support/solutions/articles/9000076120-surveyor-image-formats + tif: + description: Tagged Image File Format, abbreviated TIFF or TIF, is a computer file format for storing raster graphics images + meaning: EDAM:format_3591 + tom: + description: The .tom format is a specialized 3D image export format from the Vectra medical imaging systems that can optionally preserve trimmings and/or landmarks. + notes: + - No other model has this as it is relatively new and highly specific format for a proprietary platform. + source: http://canfieldupgrade.com/assets/media/VECTRA-M3-User-Guide.pdf + ArrayFileFormatEnum: + description: File formats for array-based data + title: Array File Format + permissible_values: + Sentrix descriptor file: + description: A BeadScan specific file needed to perform scan setting checks for different array formats and assay type. + source: https://support.illumina.com/content/dam/illumina-support/documents/myillumina/dd0aff11-2664-481b-a8ce-26831a907cae/beadscan_3.0_software_addendum.pdf + bpm: + description: A beaded pool manifest. Describe the SNP or probe content on a BeadChip or in an assay pool. + source: https://support.illumina.com/datafiles.html + cel: aliases: - - odc-odbl - description: 'This license is one of the Open Data Commons licenses and allows users to share and adapt the dataset as long as they give credit to the copyright holder and distribute any additions, transformation or changes to the dataset.' - source: https://opendatacommons.org/licenses/odbl/ - title: Open Data Commons Open Database License - ODC-ODbL 1.0: + - Affymetrix probe raw data format + description: Format of Affymetrix data file of information about (raw) expression levels of the individual probes + meaning: EDAM:format_1638 + chp: aliases: - - odc-odbl-1.0 - meaning: https://opendatacommons.org/licenses/odbl/1-0/ - ODC-PDDL: + - Affymetrix probe normalised data format + description: CHP file contains probe set analysis results generated from Affymetrix software + meaning: EDAM:format_1644 + dat: aliases: - - odc-pddl - description: 'This license is one of the Open Data Commons licenses and is like a public domain dedication. The copyright holder surrenders rights in a dataset using this license.' - source: https://opendatacommons.org/licenses/pddl/ - title: Open Data Commons Public Domain Dedication and License - ODC-PDDL 1.0: + - Affymetrix image data file format + description: Format of Affymetrix data file of raw image data. + meaning: EDAM:format_1637 + idat: + description: Proprietary file format for (raw) BeadArray data used by genomewide profiling platforms from Illumina Inc. This format is output directly from the scanner and stores summary intensities for each probe-type on an array. + meaning: EDAM:format_3578 + locs: + description: Illumina iScan bead location file. + source: https://support.illumina.com/content/dam/illumina-support/documents/documentation/system_documentation/iscan/iscan-system-guide-11313539-01.pdf + MassSpecFileFormatEnum: + description: File formats for mass spectrometry data + title: Mass Spectrometry File Format + permissible_values: + msf: aliases: - - odc-pddl-1.0 - meaning: https://opendatacommons.org/licenses/pddl/1-0/ - Public Domain: + - Magellan storage file format + description: Proprietary mass-spectrometry format of Thermo Scientific's ProteomeDiscoverer software + meaning: EDAM:format_3702 + mzML: + description: mzML format for raw spectrometer output data, standardised by HUPO PSI MSS. + meaning: EDAM:format_3244 + raw: + description: Proprietary file format for mass spectrometry data from Thermo Scientific + meaning: EDAM:format_3712 + TabularFileFormatEnum: + description: Tabular data formats including spreadsheets and delimited files + title: Tabular File Format + permissible_values: + RCC: + description: Reporter Code Count-A data file (.csv) output by the Nanostring nCounter Digital Analyzer, which contains gene sample information, probe information and probe counts. + meaning: EDAM:format_3580 + csv: aliases: - - public domain - - publicdomain - description: Technically not a license, the public domain mark relinquishes all rights to a dataset and dedicates the dataset to the public domain. - source: https://creativecommons.org/public-domain/pdm/ - UNKNOWN: + - Comma-separated values + description: Tabular data represented as comma-separated values in a text file + meaning: EDAM:format_3752 + excel: + description: Microsoft Excel spreadsheet format with extension .xlsx or .xls + meaning: EDAM:format_3620 + notes: + - http://edamontology.org/format_3468 is the older version of http://edamontology.org/format_3620 + parquet: + description: An open, columnar table format that stores data by column with built-in compression and schema metadata for fast analytics. + meaning: https://parquet.apache.org/ + tsv: aliases: - - notspecified - - other-open - - other-closed - - restricted-access - description: The license for the dataset is not known. - ManifestationEnum: + - Tab-delimited + - Tab-separated values + - tab + description: Tabular data represented as tab-separated values in a text file + meaning: EDAM:format_3475 + ScriptFileFormatEnum: + description: Script and code file formats + title: Script File Format permissible_values: - Atypical Neurofibroma: + MATLAB script: aliases: - - Ancient Neurofibroma - - Neurofibroma with Atypia - Atypical Neurofibromatous Neoplasm with Uncertain Biologic Potential (ANNUBP): - Behavioral: - Breast Cancer: - Cognition: - Cutaneous Neurofibroma: + - MATLAB + - m + description: A MATLAB script file with expected extension “.m”. Note that files with a “.mat” extension contains MATLAB formatted data. + meaning: EDAM:format_4007 + Python script: aliases: - - Dermal Neurofibroma - Glioma: + - Python + - Python program + - py + description: Python script with expected extension “.py”. + meaning: EDAM:format_3996 + R script: aliases: - - glial neoplasm - - glial tumor - - neoplasm of neuroglia - - neuroglial neoplasm - - neuroglial tumor - - tumor of neuroglia - - tumour of the neuroglia - High-Grade Glioma: - Juvenile Myelomonocytic Leukemia (JMML): - Low-Grade Glioma: - Malignant Peripheral Nerve Sheath Tumor (MPNST): - Memory: - Meningioma: - Pain: - Plexiform Neurofibroma: - Quality of Life: - Schwannoma: - Spinal Meningioma (SMN): - Vision Loss: - StudyStatusEnum: - permissible_values: - Active: - description: The project is in the performance period between grant start and grant end dates. - Completed: - description: The project has reached the grant end date and all intended data has been generated and uploaded. - Withdrawn: - description: The project was planned/started but not completed (withdrawn for various reasons). - title: Study Status - Data: - description: Type of data represented by the entity (File, Dataset, etc.). - notes: - - http://edamontology.org/data_0006 - - Broad term/abstract class; should not be used for annotation + - R + - R program + description: R script with expected extension “.R”. + meaning: EDAM:format_3999 + bash script: + description: Bash shell script with .sh extension. + source: https://en.wikipedia.org/wiki/Shell_script + js: + description: File with Javascript code. + DataFileFormatEnum: + description: Structured data formats for serialization and storage + title: Data File Format permissible_values: - aligned reads: - description: Aligned reads output from alignment workflows - source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=aligned_reads - annotated germline variants: - description: Germline variants annotated with some annotation workflow - source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=annotated_germline_variation - annotated somatic mutation: - description: Somatic variants annotated with some annotation workflow - source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=annotated_somatic_mutation - audio transcript: - description: Text transcript of an audio recording. - source: https://w3id.org/synapse/nfosi/vocab/audioTranscript - behavioral data: - description: "Qualitative or quantitative behavioral measurements / observations about the action, reaction, or performance of an organism in response to external or internal stimuli. \nExamples: avoidance behavior, choice-making.\n" - notes: - - Legacy concept previously labeled "behavior process", updated to "behavioral data". - capsid sequence: - description: Sequence of capsid protein regions (AAV9, AAVsc, etc.) - meaning: EDAM:data_3494 - notes: - - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. - cellular physiology: - description: Data on the physiological parameter of a cell. - source: https://w3id.org/synapse/nfosi/vocab/cellularPhysiology - characteristic: - aliases: - - Feature - - Nature - description: Broad data type for data that can encompass volume, weight, brightness, color, capacity, etc. - meaning: NCIT:C25447 - notes: - - Not preferred for annotation; more specific term should be used. - - May cover both morphology parameter and physiology parameter. - chromatin activity: - description: Data of chromatin activity, which allows access to condensed genomic DNA and potentially controls gene expression. - see_also: - - https://en.wikipedia.org/wiki/Chromatin_remodeling - source: https://w3id.org/synapse/nfosi/vocab/chromatinActivity - clinical: - description: Data containing clinical information, e.g. patient diagnosis, personal demographics, exposures, laboratory tests, family relationships. - meaning: EFO:0030083 - notes: - - The closest EDAM term is for [EHR](http://edamontology.org/data_3861), and while [ecological data](http://edamontology.org/data_3736), there is no mapping, which is why we use EFO. - see_also: - - https://docs.gdc.cancer.gov/Encyclopedia/pages/Clinical_Data - copy number variants: - description: Copy number variants - source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=copy_number_variation - count matrix: - aliases: - - Read count matrix - description: A table of unnormalized values representing summarised read counts per genomic region (e.g. gene, transcript, peak). - meaning: EDAM:data_3917 - data index: - description: A data index is information used to help with retrieval of some other data, especially large-scale data that would benefit from such an index. Very common formats are .bai and .tbi. - meaning: EDAM:data_0955 - data sharing plan: + MATLAB data: aliases: - - DMP - - Data Management Plan - - Data Landscape Survey - description: A document containing the plan and documentation for data sharing, one component of overall data management. - meaning: EDAM:data_4040 - notes: - - Technically EDAM term is 'data management plan', which is more encompassing in scope. - - Use for tagging uploaded data sharing plans. - demographics: + - .mat file format + - MATLAB file format + description: A MATLAB formatted data file with expected extension “.mat”. + meaning: EDAM:format_3626 + RData: + description: The RData format (usually with extension .rdata or .rda) is a format designed for use with R, a system for statistical computation and related graphics, for storing a complete R workspace or selected 'objects' from a workspace in a form that can be loaded back by R. + source: https://www.loc.gov/preservation/digital/formats/fdd/fdd000470.shtml + SDAT: + description: Phillips MRS Data File + source: https://github.com/chenkonturek/MRS_MRI_libs + SPAR: + description: Phillips MRS Header File + source: https://github.com/chenkonturek/MRS_MRI_libs + json: aliases: - - Demographic Factor - - Demography - - Population Studies / Demography - description: The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income). - meaning: NCIT:C16495 - drug combination screen: - description: Information on drug sensitivity of more than one compound - source: https://www.ncbi.nlm.nih.gov/pubmed/29344898 - drug screen: - description: Information on drug sensitivity and molecular markers of drug response - source: https://w3id.org/synapse/nfosi/vocab/drugScreen - electrophysiology: - description: "Data generated from an electrophysiology assay, e.g: \n- Cell: Resting membrane potential, ion channel currents (patch clamp data)\n- Neurons: Action potentials, resting potential, synaptic potentials. \n- Heart: Electrocardiogram (ECG/EKG) waveforms, cardiac action potentials.\n- Muscle: Electromyogram (EMG) signals\n- Whole brain: Electroencephalogram (EEG)\n- Retina: Electroretinogram (ERG)\n" - notes: - - ERO has been deprecated and direct URIs no longer work. - source: https://bioportal.bioontology.org/ontologies/ERO/?p=classes&conceptid=http%3A%2F%2Fpurl.obolibrary.org%2Fobo%2FERO_0000564&jump_to_nav=true - epidemiological data: - description: Data that is used to describe the distribution of a disease or health-related characteristic within a population and to identify factors that affect that distribution. - gene expression: - description: Data of the levels and patterns of synthesis of gene products (proteins and functional RNA), including interpretation in functional terms of gene expression data. - meaning: EDAM:data_2603 - notes: - - EDAM does have a broader mapping, [expression data](http://edamontology.org/data_2603) - - The mapping used maps to [gene expression profile](http://edamontology.org/data_0928) - - Covers both raw (e.g. fastqs, microarray intensities) and processed gene expression data (e.g. normalized gene expression matrix). - gene expression matrix: + - JavaScript Object Notation + description: JavaScript Object Notation format; a lightweight, text-based format to represent tree-structured data using key-value pairs. + meaning: EDAM:format_3464 + prism: aliases: - - Gene expression data matrix - - Normalised microarray data - description: The final processed (normalised) data for a set of hybridisations in a microarray experiment. This combines data from all hybridisations. - meaning: EDAM:data_3112 - quantified gene expression: - description: Expression measurements that have been summarized or normalized, typically representing quantified abundance metrics rather than raw instrument output. - genomic features: - description: Data of sequence feature (continuous extent of biological sequence) that is of genomic origin. - meaning: GENO:0000481 - notes: - - Really subclass of "nucleic acid features" (http://edamontology.org/data_1276) - see_also: https://en.wikipedia.org/wiki/General_feature_format - genomic variants: + - GraphPad Prism file + description: GraphPad Prism native file format (Prism 10+) for storing data tables, graphs, layouts, and analysis results. Uses an open access format leveraging industry standards. + source: https://www.graphpad.com/features + rds: + description: R binary data format similar to RData. + source: https://www.datafiles.samhsa.gov/get-help/format-specific-issues/how-do-i-read-data-r + sqlite: + description: Data format used by the SQLite database. + meaning: EDAM:format_3621 + xml: aliases: - - Gene sequence variations - description: 'Genomic alterations, including single nucleotide polymorphisms, short indels and structural variants. Use more specific term if possible, esp. if data is only of one specific subset. + - eXtensible Markup Language + description: eXtensible Markup Language (XML) format. + meaning: EDAM:format_2332 + yaml: + description: YAML (YAML Ain't Markup Language) is a human-readable tree-structured data serialisation that is a superset of JSON (as of v1.2). + meaning: EDAM:format_3750 + ArchiveFileFormatEnum: + description: Compressed archive and container formats + title: Archive File Format + permissible_values: + 7z: + aliases: + - 7Z Compression Format + description: A compressed archive file format that supports several different data compression, encryption and pre-processing filters. + meaning: NCIT:C80224 + docker image: + description: 'A Docker image is a file, comprised of multiple layers, that is used to execute code in a Docker container. An image is essentially built from the instructions for a complete and executable version of an application, which relies on the host OS kernel ' - meaning: EDAM:data_3498 - notes: - - Somewhat more specific than the concept URI it is mapped to. - germline variants: - description: Called germline variants - source: https://docs.gdc.cancer.gov/Data_Dictionary/viewer/#?view=table-definition-view&id=simple_germline_variation - guide RNA sequence: - aliases: - - sgRNA sequence - - gRNA sequence - description: Sequence data for guide RNAs used in CRISPR or other gene editing experiments. - meaning: EDAM:data_3494 - notes: - - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. - image: + meaning: EDAM:format_3973 + gzip: aliases: - - Image data - description: Biological or biomedical data that has been rendered into an image. - meaning: EDAM:data_2968 - immunoassay: + - GNU Zip + - gz + description: GZipped format + meaning: EDAM:format_3989 + tar: aliases: - - Immunological Laboratory Method - - Immunology Test - description: Laboratory test involving interaction of antigens with specific antibodies. - meaning: NCIT:C16723 - isoform expression: + - Tarball + description: TAR archive file format generated by the Unix-based utility tar. + meaning: EDAM:format_3981 + zip: + description: zip is a format standard of a digital entity that is conformant with the PKWARE .ZIP file format specification + meaning: EDAM:format_3987 + DocumentFileFormatEnum: + description: Document and text formats + title: Document File Format + permissible_values: + ai: + description: Adobe Illustrator format + meaning: SWO:3000023 + doc: aliases: - - Isoform Measurement - - Isoform Quantitation - - Protein Isoform Measurement - - Protein Isoform Quantitation - description: Expression of protein isoforms formed from alternative splicings or other post-translational modifications of a single gene through RNA splicing mechanisms. - meaning: NCIT:C184767 - source: https://en.wikipedia.org/wiki/Protein_isoform - kinomics: - description: Data studying protein kinase signaling/activity. - notes: - - See "Kinome Response Profile" (http://purl.obolibrary.org/obo/NCIT_C107137) for kinome data *specifically* with drug treatment - - Subclasss of "Proteomics" (http://purl.obolibrary.org/obo/NCIT_C16723) - source: https://w3id.org/synapse/nfosi/vocab/kinomics - mask image: - description: Image used as the mask for an image processing operation, such as subtraction. - meaning: DCM:121321 - mass spectrometry data: - description: Data from mass spectrometry measurement. - meaning: EDAM:data_2536 - metabolomics: - description: Data of metabolites, the chemical processes they are involved, and the chemical fingerprints of specific cellular processes in a whole cell, tissue, organ or organism. - see_also: - - http://edamontology.org/topic_3172 - source: https://w3id.org/synapse/nfosi/vocab/metabolomics - molecular property: + - Microsoft Word format + description: Microsoft Word document format + meaning: EDAM:format_3506 + html: aliases: - - Physicochemical property - description: Data on the physical (e.g. structural) or chemical properties of molecules, or parts of a molecule. - meaning: EDAM:data_2087 - morphology parameter: - description: Experimentally determined parameter of the morphology of an organism, e.g. size & shape. General term representing data about **structure** and **form** of an organism or organism part. - meaning: EDAM:data_3723 - network: + - Hypertext Markup Language + description: HTML format + meaning: EDAM:format_2331 + hyperlink: aliases: - - Pathway - description: Network data represents connections between entities and are often in graphical format. - meaning: EDAM:data_2600 + - Link + - www-links + description: A reference (link) from some point in one hypertext document to another document, another place in the same document, or a website. + meaning: NCIT:C47919 + md: + description: Markdown (MD) is a lightweight markup language with plain text formatting syntax notes: - - EDAM preferred label is 'Pathway or network' - nucleic acid sequence record: + - Strangely, EDAM has [R markdown](http://edamontology.org/format_4000) but not markdown + source: https://en.wikipedia.org/wiki/Markdown + pdf: + description: Portable Document Format + meaning: EDAM:format_3508 + powerpoint: + description: Microsoft Powerpoint slide format + meaning: EDAM:format_3838 + txt: + description: Textual format + meaning: EDAM:format_2330 + OtherFileFormatEnum: + description: Other specialized file formats + title: Other File Format + permissible_values: + MPEG-4: aliases: - - Nucleotide sequence record - - Sequence record (nucleic acid) - description: A nucleic acid sequence and associated metadata. - meaning: EDAM:data_2887 - notes: - - Can be used for .dna (SnapGene) files. - over-representation data: + - MP4 + description: A digital multimedia container format most commonly used to store video and audio. + meaning: EDAM:format_3997 + ab1: + description: TAB1 binary format of raw DNA sequence reads (output of Applied Biosystems' sequencing analysis software). Contains an electropherogram and the DNA base sequence. + meaning: EDAM:format_3000 + abf: + description: The Axon Binary File format (ABF) was created for the storage of binary experimental data. + source: https://mdc.custhelp.com/euf/assets/content/ABFHelp.pdf + dna: + description: Propietary SnapGene file format. + source: https://www.snapgene.com/guides/convert-genbank-files + edat3: + description: The .edat3 proprietary format is used to store experiment data that can be analyzed in E-DataAid. + source: https://support.pstnet.com/hc/en-us/articles/229354727-INFO-E-Prime-file-extensions-18091 + fcs: + description: Format standard of a digital entity that is conformant with the Flow Cytometry Data File Standard + meaning: OBI:0000327 + fig: + description: Line drawing saved in the Xfig format; stored as a vector image that may include lines, shapes, arcs, splines, arrows, and text objects; may also include images, colors, and patterns. + source: https://fileinfo.com/extension/fig + gb: + description: GenBank Sequence Format (GenBank Flat File Format) consists of an annotation section and a sequence section. The start of the annotation section is marked by a line beginning with the word "LOCUS". The start of sequence section is marked by a line beginning with the word "ORIGIN" and the end of the section is marked by a line with only "//". + meaning: EDAM:format_1936 + source: https://fairsharing.org/833 + hdf5: aliases: - - Enrichment report - - Over-representation report - description: A ranked list of categories (usually ontology concepts), each associated with a statistical metric of over-/under-representation within the studied data. - meaning: EDAM:data_3753 - particle characterization: - description: Data providing information about entities such as composition, structure and defects. - meaning: NCIT:C62317 + - h5 + description: 'HDF5 is the new version, according to the HDF group, a completely different technology (https://support.hdfgroup.org/products/hdf4/ compared to HDF. An HDF5 file appears to the user as a directed graph. The nodes of this graph are the higher-level HDF5 objects that are exposed by the HDF5 APIs: Groups, Datasets, Named datatypes. Currently supported by the Python MDTraj package. HDF5 is a data model, library, and file format for storing and managing data, based on Hierarchical Data Format (HDF). + +' + meaning: EDAM:format_3590 notes: - - More general than `molecular property` - pharmacokinetics: - aliases: - - PK Study - - Pharmacokinetic Study - description: Data characterizing the process by which a drug is absorbed, distributed, metabolized, and eliminated by the body. - meaning: NCIT:C49663 - physiology parameter: - description: Experimentally determined parameter of the physiology of an organism, e.g. metabolic rate. General term representing data about **function** and **process** of an organism or organism part. - meaning: EDAM:data_3722 - notes: - - Relation to pharmacokinetic data -- certain physiology parameteres inherent to the organism influences its pharmokinetics of a drug. - plasmid sequence: - description: Sequence data for plasmid vectors used in cloning or gene expression experiments. - meaning: EDAM:data_3494 + - This file format encompasses/includes the h5ad anndata format commonly used for scRNAseq data sharing. + idx: + description: '' + psydat: + description: TrialHandler or StairHandler object that has been saved to disk with the python cPickle module, ideal for batch analysis and plotting with Python. notes: - - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. - plot: + - Not in EDAM as of April 2024. + source: https://www.psychopy.org/general/dataOutputs.html + pzfx: + description: Legacy GraphPad Prism XML file format (Prism 5-9) for storing project data including graphs, layouts, notes, and tables. Superseded by the .prism format in Prism 10+. + source: https://fileinfo.com/extension/pzfx + rmd: + description: Markdown document specific to R analyses. + meaning: EDAM:format_4000 + source: http://rmarkdown.rstudio.com/developer_document_templates.html + sav: + description: The SPSS Statistics File Format is a proprietary binary format, developed and maintained as the native format for the SPSS statistical software application. + source: https://www.loc.gov/preservation/digital/formats/fdd/fdd000469.shtml + sdf: + description: SDF is one of a family of chemical-data file formats developed by MDL Information Systems; it is intended especially for structural information. + meaning: EDAM:format_3814 + sif: + description: SIF (simple interaction file) Format - a network/pathway format used for instance in cytoscape + meaning: EDAM:format_3619 + svg: aliases: - - Graph data - description: Data that has been plotted as a graph of some type, or data representing such a graph. - meaning: EDAM:data_2884 - primer sequence: - description: Sequence data for oligonucleotide primers used in PCR or sequencing experiments. - meaning: EDAM:data_3494 - notes: - - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. - probe sequence: - description: Sequence data for nucleic acid probes used in hybridization experiments. - meaning: EDAM:data_3494 - notes: - - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. - promoter sequence: - description: Sequence data of promoter region (P0, flCAG, etc.) - meaning: EDAM:data_3494 - notes: - - Mapping to broader concept since EDAM doesn't have further granularity for sequence data. - protein interaction data: + - Scalable Vector Graphics + description: Scalable Vector Graphics (SVG) is an XML-based vector image format for two-dimensional graphics with support for interactivity and animation. + meaning: EDAM:format_3604 + CuratedDataEnum: + permissible_values: + chemical descriptor: + description: A chemical descriptor is a data item (quantity or value) about a chemical entity that conforms to a specification for how it is calculated, measured or recorded. + meaning: CHEMINF:000123 + clinical data: aliases: - - Protein interaction record - - Protein report (interaction) - - Protein-protein interaction data - description: 'Data concerning the interactions (predicted or known) within or between a protein, structural domain or part of a protein. This includes intra- and inter-residue contacts and distances, as well as interactions with other proteins and non-protein entities such as nucleic acid, metal atoms, water, ions etc. + - Clinical + description: Data obtained through patient examination or treatment. + meaning: NCIT:C15783 + gene function: + description: A term that expresses the function of a gene product. + meaning: NCIT:C48933 + gene symbol: + aliases: + - Gene Name + - Official Gene Name + - gene + description: A unique gene name approved by an organism specific nomenclature committee. + meaning: NCIT:C43568 + Resource: + description: 'Resource classes. Most resource entities expected to be some type of "experimental data" and further specified via `dataType`. ' - meaning: EDAM:data_0906 - protein interaction raw data: - description: Protein-protein interaction data from for example yeast two-hybrid analysis, protein microarrays, immunoaffinity chromatography followed by mass spectrometry, phage display etc. - meaning: EDAM:data_0905 - proteomics: - description: Protein and peptide identification, especially in the study of whole proteomes of organisms. - meaning: EDAM:topic_0121 - raw counts: - aliases: - - Count - - NUMBER - - Num - - Number Count - description: The number or amount of something. - meaning: NCIT:C25463 - reference sequence: - description: Generic sequence data used as a reference in experimental design or analysis. - meaning: EDAM:data_3494 - notes: - - Use more specific sequence type if applicable (e.g., primer sequence, plasmid sequence). + permissible_values: + experimentalData: + description: Any file derived from or pertaining to a scientific experiment. Experimental data annotations should be applied, possibly disease-related. + metadata: + description: Data about data, information that describes another set of data. + meaning: NCIT:C52095 + protocol: + description: A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process. + meaning: OBI:0000272 report: aliases: - Document - Record - description: A human-readable collection of information including annotation on a biological entity or phenomena, computer-generated reports of analysis of primary data... as distinct from the primary data itself. - meaning: EDAM:data_2048 - somatic variants: - description: Called somatic variants - source: https://w3id.org/synapse/nfosi/vocab/SomaticVariants - structural variants: - description: Genomic variants data that covers deletions, duplications, CNVs, insertions, inversions, and translocations, which may be derived from specialized variant calling workflows. - source: https://w3id.org/synapse/nfosi/vocab/StructuralVariantss - survey data: - description: A data set that contains the outcome of a survey. - meaning: OMIABIS:0000060 - text data: - description: Data that is represented as text, usually referring to "unstructured data". - meaning: EDAM:data_2526 - volume: - aliases: - - Total Volume - - Vol - description: Data of the three dimensional space occupied by an entity or the capacity of a space or container. - meaning: NCIT:C25335 - weight: - description: The vertical force exerted by a mass as a result of gravity. - meaning: NCIT:C25208 - DataSubtypeEnum: - description: 'Categorizes data based on its processing state. This is the main classification axis used for data types. Not all data types can use this dimensions (e.g. clinical data). + description: 'A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record). ' + meaning: IAO:0000088 + result: + comments: This resource category is somewhat more general than `report`. + description: Any file that reports data results. Examples include figures, presentations, analysis, etc. + source: https://synapse.org + tool: + description: Any file or link that represents a tool, model, or algorithm; the tool annotations could be applied + source: https://synapse.org + weblink: + aliases: + - URL + - Uniform Resource Locator + description: An address to another document or other resource on the World Wide Web. + meaning: NCIT:C42743 + workflow report: + description: Workflow-generated reports of analysis of primary data, usually created programmatically at completion of workflow step. + AccessTypeEnum: + notes: + - Historically has been used with `accessTeam` especially if "PRIVATE". + - All files have to qualify to be labeled as such, e.g. a single Controlled Access file will make the dataset Controlled Access. + - This is not personalized to the user. They will have to evaluate it from their perspective, we are not dynamically rendering this. + - See also https://github.com/PAIR-code/datacardsplaybook/blob/main/templates/DataCardsExtendedTemplate.md#access-type permissible_values: - derived: - description: Data from additional analytical steps performed on already processed data. - normalized: - description: Data that has undergone a normalization procedure to adjust for technical variation or to bring measurements onto a common scale. Considered a more specific type of processed data. - meaning: OBI:0000451 - processed: - description: Data generated from running one or more bioinformatics methods on raw data. - quantified: - description: Data representing measurements/counts of specific features (gene counts, peak intensities, object properties). - raw: - description: Data produced by experimental measurement/observation with very little subsequent processing. - synthetic: - description: Data generated computationally via models or simulations, not direct experimental measurement. - MetadataEnum: - description: Data that provides information about other data + Controlled Access: + description: 'Access is restricted and only available after fulfilling specific requirements, such as submitting a research statement or getting approval directly from the data owner through Synapse. Note that for datasets, if any component file is under controlled access, the entire dataset is considered to be under controlled access.' + Open Access: + description: Access without any additional steps/requirements without even needing to be logged in to Synapse account. + Private Access: + description: Not accessible outside the project admins and study team -- check whether you are on an access team or contact the PI/admin of access team to request access. + Public Access: + description: Access without any additional steps/requirements as long as you are logged in to Synapse. + title: Access type + DataCatalogEnum: permissible_values: - descriptive metadata: - description: Information that describes and identifies a resource, including elements that facilitate discovery and understanding. - notes: - - Currently used for `manifest.csv` files. - image metadata: - aliases: - - Image-associated data - - Image-related data - description: Data concerning a specific biological or biomedical image. - meaning: EDAM:data_3546 + https://www.synapse.org/DataCatalog:0: + https://nf.synapse.org/Explore/Datasets: + DataSeriesEnum: + permissible_values: + NF-OSI Processed Data: + None: + DataStatusEnum: + permissible_values: + Available: + description: Data is fully available for download for the project (with fulfillment of any governance requirements). + Data Not Expected: + description: Data is not expected for the project. + Data Pending: + description: There is no data yet in the project because it is still being generated or has not yet been uploaded yet. + Partially Available: + description: Some data is available for download for the project. + Rolling Release: + description: This project has an ongoing cycle of incoming data that is released in batches. + Under Embargo: + description: Data is present in the project but not accessible to anyone outside the project admins and study team. notes: - - For e.g. XML files that contain image metadata. - metadata: - description: Most general label for data that contains information about data. - workflow metadata: - comments: Coined category for use esp. with nextflow metadata files. - description: Process data from computational workflows. This is highly related to Statistical Metadata. Basic information, annotation or documentation concerning a workflow (but not the workflow itself). - meaning: EDAM:data_0949 - source: https://en.wikipedia.org/wiki/Metadata - NotApplicableEnum: + - When data is first uploaded, the status should change from “Data Pending” to “Under Embargo”. + title: Data Status + DiseaseFocusEnum: permissible_values: - Not Applicable: - description: Not applicable in this context - UnknownEnum: + 22q-related schwannomatosis: + LZTR1-related schwannomatosis: + Multiple: + NF2-related schwannomatosis: + Neurofibromatosis type 1: + SMARCB1-related schwannomatosis: + Schwannomatosis-NEC: + Schwannomatosis-NOS: + title: Disease Focus + DuoEnum: permissible_values: - Unknown: - aliases: - - Not Known - - U - - UNK - - Unknown/Not Stated - description: Not known, observed, recorded; or reported as unknown by the data contributor. - meaning: NCIT:C17998 - SequencingFileFormatEnum: - description: File formats for sequencing data including alignments, variants, and genomic annotations - title: Sequencing File Format + Clinical Care Use: + description: Clinical Care Use + Collaboration Required: + description: Collaboration Required - PI Contact information required + Disease Specific Research: + description: Disease Specific Research - Provide detail [DOID] or [MONDO] + Ethics Approval Required: + description: Ethics Approval Required - User prompted to provide IRB/IEC approval + General Research Use: + description: General Research Use + Genetic Studies Only: + description: Genetic Studies Only + Geographical Restriction: + description: Geographical Restriction - Provide country restriction [ISO 3166⍺2] + Health or Medical or Biomedical Research: + description: Health or Medical or Biomedical Research + Institution Specific Restriction: + description: Institution Specific Restriction - Name Institution [ror.org] + No General Methods Research: + description: No General Methods Research + No Restriction: + description: No Restriction - Data is available under Open or Anonymous access + Non-Commercial Use Only: + description: Non-Commercial Use Only + Not-for-Profit Non-Commercial Use Only: + description: Not-for-Profit, Non-Commercial Use Only + Not-for-Profit Organisation Use Only: + description: Not-for-Profit Organisation Use Only + Population Origins or Ancestry Research Only: + description: Population Origins or Ancestry Research Only - User must describe research use in IDU statement + Population Origins or Ancestry Research Prohibited: + description: Population Origins or Ancestry Research Prohibited + Project Specific Restriction: + description: Project Specific Restriction - User prompted to provide IDU statement + Publication Moratorium: + description: Publication Moratorium - Provide date [ISO 8601] + Publication Required: + description: Publication Required + Research Specific Restrictions: + description: Research Specific Restrictions - Provide detail + Return to Database or Resource: + description: Return to Database or Resource + Time Limit on Use: + description: Time Limit on Use - Provide date [ISO 8601] + User Specific Restriction: + description: User Specific Restriction - User may be required to register, enhance their profile, join a Synapse Team, or have a specific authentication, e.g., 2FA or RAS + title: Data Use Modifiers + FundingAgencyEnum: permissible_values: - bai: - description: BAM indexing format - meaning: EDAM:format_3327 - bam: - description: BAM format, the binary, BGZF-formatted compressed version of SAM format for alignment of nucleotide sequences (e.g. sequencing reads) to (a) reference sequence(s) - meaning: EDAM:format_2572 - bcf: - description: BCF, the binary version of Variant Call Format (VCF) for sequence variation (indels, polymorphisms, structural variation) - meaning: EDAM:format_3016 - bed: - description: Browser Extensible Data (BED) format of sequence annotation track, typically to be displayed in a genome browser - meaning: EDAM:format_3003 - bed broadPeak: - description: This format is used to provide called regions of signal enrichment based on pooled, normalized (interpreted) data. It is a BED 6+3 format. - source: http://genome.ucsc.edu/FAQ/FAQformat.html#format13 - bed gappedPeak: - description: This format is used to provide called regions of signal enrichment based on pooled, normalized (interpreted) data where the regions may be spliced or incorporate gaps in the genomic sequence. It is a BED12+3 format. - source: http://genome.ucsc.edu/FAQ/FAQformat.html#format14 - bed narrowPeak: - description: This format is used to provide called peaks of signal enrichment based on pooled, normalized (interpreted) data. It is a BED6+4 format. - source: http://genome.ucsc.edu/FAQ/FAQformat.html#format12 - bedgraph: - description: Holds a tab-delimited chromosome /start /end / datavalue dataset. The bedGraph format allows display of continuous-valued data in track format. This display type is useful for probability scores and transcriptome data - meaning: EDAM:format_3583 - bgzip: - description: Blocked GNU Zip format - meaning: EDAM:format_3615 - bigwig: - description: bigWig format for large sequence annotation tracks that consist of a value for each sequence position - meaning: EDAM:format_3006 - cnn: - description: Copy number reference profile from CNVKit pipeline. - source: https://cnvkit.readthedocs.io/en/stable/fileformats.html - cnr: - description: Copy number ratios from CNVKit pipeline, storing each bin's proportional weight or reliability. - source: https://cnvkit.readthedocs.io/en/stable/fileformats.html - cns: - description: Segmented log2 ratios from CNVKit pipeline, these represent the most relevant output describing copy number variation. - source: https://cnvkit.readthedocs.io/en/stable/fileformats.html - crai: - description: A CRAI file is an index for a CRAM file, facilitating fast data retrieval. - notes: - - ChatGPT (September 25, 2023 Version) - cram: - description: A CRAM file is a compressed format for storing genomic sequence data. - meaning: EDAM:format_3462 - notes: - - ChatGPT (September 25, 2023 Version) - csi: - description: A CSI file is a compressed sequence index used for efficiently accessing genomic data in large datasets. - notes: - - ChatGPT (September 25, 2023 Version) - ctab: - description: Gene expression counts file and a specific format of .tsv commonly part of bioinformatics workflows (Stringtie and Ballgown). - source: https://github.com/alyssafrazee/ballgown#ballgown-readable-expression-output - dup: - description: output of the Picard MarkDuplicates tool. - source: https://software.broadinstitute.org/gatk/documentation/tooldocs/4.0.4.0/picard_sam_markduplicates_MarkDuplicates.php - fasta: + CTF: + GFF: + Independent: + NIH-NCI: + NTAP: + Other: + License: + description: License attached to the data. If indicates UNKNOWN or RESTRICTED-USE, data may not be used without further contact for terms. + notes: + - https://libanswers.ucalgary.ca/faq/200582 + - https://resources.data.gov/open-licenses/ + - https://the-turing-way.netlify.app/reproducible-research/licensing/licensing-data.html + - https://help.figshare.com/article/what-is-the-most-appropriate-licence-for-my-research + permissible_values: + CC BY-NC: aliases: - - FASTA format - - FASTA sequence format - description: FASTA format is a text-based format for representing either nucleotide sequences or peptide sequences, in which nucleotides or amino acids are represented using single-letter codes - meaning: EDAM:format_1929 - fastq: + - cc-by-nc + description: 'This license is one of the Creative Commons licenses and allows users to share and adapt the dataset if they give credit to the copyright holder and do not use the dataset for any commercial purposes.' + source: https://creativecommons.org/licenses/by-nc/4.0/ + title: Creative Commons Attribution-NonCommercial 4.0 International + CC BY-NC 4.0: aliases: - - fq - description: FASTQ format is a text-based format for storing both a biological sequence (usually nucleotide sequence) and its corresponding quality scores. Both the sequence letter and quality score are each encoded with a single ASCII character for brevity - meaning: EDAM:format_1930 - flagstat: - description: Output of samtools flagstat tool - gct: + - cc-by-nc-4.0 + - cc by-nc 4.0 + meaning: https://creativecommons.org/licenses/by-nc/4.0/ + CC BY-NC 3.0: aliases: - - GCT format - - Res format - description: Tab-delimited text files of GenePattern that contain a column for each sample, a row for each gene, and an expression value for each gene in each sample - meaning: EDAM:format_3709 - gff3: - description: Generic Feature Format version 3 (GFF3) of sequence features. - meaning: EDAM:format_1975 - gtf: - description: Gene transfer format (GTF) is a file format used to hold information about gene structure - meaning: EDAM:format_2306 - source: https://en.wikipedia.org/wiki/Gene_transfer_format - hic: - description: Hi-C contact matrix file - source: https://github.com/theaidenlab/juicer/wiki/Data - maf: - description: Mutation annotation format as outputted from GenomeNexus. - notes: - - DO NOT use http://edamontology.org/format_3008 as that refers to Multiple Alignment Format (MAF). - source: https://docs.gdc.cancer.gov/Data/File_Formats/MAF_Format - mtx: - description: Matrix Market Exchange Format - meaning: EDAM:format_3916 - source: https://math.nist.gov/MatrixMarket/formats.html#MMformat - plink: - description: Any Plink file format (MAP/PED/BED/BIM/FAM) - source: https://www.cog-genomics.org/plink2/formats - recal: - description: .recal file from GATK VQSR - source: https://software.broadinstitute.org/gatk/documentation/tooldocs/3.8-0/org_broadinstitute_gatk_tools_walkers_variantrecalibration_VariantRecalibrator.php#--recal_file - sam: - description: Sequence Alignment/Map (SAM) format for alignment of nucleotide sequences (e.g. sequencing reads) to (a) reference sequence(s) - meaning: EDAM:format_2573 - seg: - description: SEG file (segmented data; .seg or .cbs) is a tab-delimited text file that lists loci and associated numeric values - source: https://software.broadinstitute.org/software/igv/SEG - sf: - description: Salmon's main output is its quantification file. This file is a plain-text, tab-separated file with a single header line (which names all of the columns). - source: https://salmon.readthedocs.io/en/latest/file_formats.html - sra: + - cc-by-nc-3.0 + meaning: https://creativecommons.org/licenses/by-nc/3.0/ + CC BY-NC 2.5: aliases: - - SRA archive format - description: SRA archive format (SRA) is the archive format used for input to the NCBI Sequence Read Archive. - meaning: EDAM:format_3698 - tagAlign: - description: Tag Alignment provides genomic mapping of short sequence tags. - source: https://genome.ucsc.edu/FAQ/FAQformat.html#format15 - tbi: + - cc-by-nc-2.5 + meaning: https://creativecommons.org/licenses/by-nc/2.5/ + CC BY-NC 2.0: aliases: - - TBI Format - - Tabix - description: A TBI file is an index for a TABIX-compressed genomic data file, enabling rapid region-based retrieval. - meaning: NCIT:C184806 - tranches: - description: .tranches file from GATK VQSR - source: https://software.broadinstitute.org/gatk/documentation/tooldocs/3.8-0/org_broadinstitute_gatk_tools_walkers_variantrecalibration_VariantRecalibrator.php#--tranches_file - vcf: - description: Variant Call Format (VCF) for sequence variation (indels, polymorphisms, structural variation) - meaning: EDAM:format_3016 - wiggle: - description: Wiggle format (WIG) of a sequence annotation track that consists of a value for each sequence position - meaning: EDAM:format_3005 - ImagingFileFormatEnum: - description: File formats for imaging data including medical imaging and microscopy - title: Imaging File Format - permissible_values: - DICOM: - description: A comprehensive set of standards for communications between medical imaging devices, including handling, storing and transmitting information in medical imaging. It includes a file format definition and a network communication protocol. - meaning: EDAM:format_3548 - NWB: - description: Neurodata Without Borders (NWB) is a data standard for neurophysiology data, designed to store data including from intracellular and extracellular electrophysiology experiments, data from optical physiology experiments, and tracking and stimulus data. - source: https://www.nwb.org/ - PAR: - description: This is yet another MRI image format generated by Philips scanners. It is an ASCII header (PAR) plus a binary blob (REC). - source: https://nipy.org/nibabel/reference/nibabel.parrec.html - REC: - description: This is yet another MRI image format generated by Philips scanners. It is an ASCII header (PAR) plus a binary blob (REC). - source: https://nipy.org/nibabel/reference/nibabel.parrec.html - aci: - description: Leica image archive format - UTF-8 encoded microscopy data format used by Leica Confocal Software systems. - source: https://filext.com/file-extension/ACI - avi: + - cc-by-nc-2.0 + meaning: https://creativecommons.org/licenses/by-nc/2.0/ + CC BY-NC 1.0: + aliases: + - cc-by-nc-1.0 + meaning: https://creativecommons.org/licenses/by-nc/1.0/ + CC BY-NC-ND: + aliases: + - cc-by-nc-nd + description: 'This license is one of the Creative Commons licenses and allows users to use only your unmodified dataset if they give credit to the copyright holder and do not share it for commercial purposes. Users cannot make any additions, transformations or changes to the dataset under this license.' + source: https://creativecommons.org/licenses/by-nc-nd/4.0/ + title: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International + CC BY-NC-ND 4.0: + aliases: + - cc-by-nc-nd-4.0 + meaning: https://creativecommons.org/licenses/by-nc-nd/4.0/ + CC BY-NC-ND 3.0: + aliases: + - cc-by-nc-nd-3.0 + meaning: https://creativecommons.org/licenses/by-nc-nd/3.0/ + CC BY-NC-ND 2.5: + aliases: + - cc-by-nc-nd-2.5 + meaning: https://creativecommons.org/licenses/by-nc-nd/2.5/ + CC BY-NC-ND 2.0: + aliases: + - cc-by-nc-nd-2.0 + meaning: https://creativecommons.org/licenses/by-nc-nd/2.0/ + CC BY-NC-ND 1.0: + aliases: + - cc-by-nc-nd-1.0 + meaning: https://creativecommons.org/licenses/by-nc-nd/1.0/ + CC BY-NC-SA: + aliases: + - cc-by-nc-sa + description: 'This license is one of the Creative Commons licenses and allows users to share the dataset only if they (1) give credit to the copyright holder, (2) do not use the dataset for any commercial purposes, and (3) distribute any additions, transformations or changes to the dataset under this same license.' + source: https://creativecommons.org/licenses/by-nc-sa/4.0/ + title: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International + CC BY-NC-SA 4.0: aliases: - - Audio Video Interleaved - description: AVI files can contain both audio and video data in a file container that allows synchronous audio-with-video playback. - meaning: EDAM:format_3990 - source: https://en.wikipedia.org/wiki/Audio_Video_Interleave - bmp: - description: Bitmap image format. - meaning: EDAM:format_3592 - czi: - description: Microscopy imaging file format that saves multidimensional images such as time lapse, Z-stacks, multiposition experiments and virtual slides, combined with relevant meta information - source: https://www.zeiss.com/microscopy/int/products/microscope-software/zen/czi.html - hdr: - description: MRI Header file, as in the NIFTI-1 Analyze 7.5 format - source: https://nifti.nimh.nih.gov/pub/dist/src/niftilib/nifti1.h - img: - description: MRI Data file, as in the NIFTI-1 Analyze 7.5 format - source: https://nifti.nimh.nih.gov/pub/dist/src/niftilib/nifti1.h - jpg: + - cc-by-nc-sa-4.0 + meaning: https://creativecommons.org/licenses/by-nc-sa/4.0/ + CC BY-NC-SA 3.0: aliases: - - JPEG - description: Joint Picture Group file format for lossy graphics file. - meaning: EDAM:format_3579 - lif: - description: Leica Image Format (LIF) images are JPEG images with metadata that may contain depth, bokeh data, and one or more images (e.g. stereo images) known as "views". - source: https://docs.openmicroscopy.org/bio-formats/5.8.2/formats/leica-lif.html - mov: - description: A video file format with the .mov extension - source: https://synapse.org - nii: + - cc-by-nc-sa-3.0 + meaning: https://creativecommons.org/licenses/by-nc-sa/3.0/ + CC BY-NC-SA 2.5: aliases: - - NIFTI format - description: NIfTI-1 can store image data from any modality such as PET, MRI, CT, EEG that produces regularly sampled 1-5D rasters. - meaning: EDAM:format_3549 - source: https://nifti.nimh.nih.gov/nifti-1/documentation/faq - ome-tiff: - description: OME-TIFF is a preferred open image format - meaning: EDAM:format_3727 - png: - description: PNG is a file format for image compression - meaning: EDAM:format_3603 - svs: - description: A single-file pyramidal tiled TIFF, with non-standard metadata and compression. - source: https://openslide.org/formats/aperio/ - sws: - description: Surveyor Workspace format - a tiled microscopy image format from Objective Imaging systems comprising folders with high-resolution image tiles, thumbnails, metadata files, and a .sws file. - source: https://objectiveimaging.freshdesk.com/support/solutions/articles/9000076120-surveyor-image-formats - tif: - description: Tagged Image File Format, abbreviated TIFF or TIF, is a computer file format for storing raster graphics images - meaning: EDAM:format_3591 - tom: - description: The .tom format is a specialized 3D image export format from the Vectra medical imaging systems that can optionally preserve trimmings and/or landmarks. - notes: - - No other model has this as it is relatively new and highly specific format for a proprietary platform. - source: http://canfieldupgrade.com/assets/media/VECTRA-M3-User-Guide.pdf - ArrayFileFormatEnum: - description: File formats for array-based data - title: Array File Format - permissible_values: - Sentrix descriptor file: - description: A BeadScan specific file needed to perform scan setting checks for different array formats and assay type. - source: https://support.illumina.com/content/dam/illumina-support/documents/myillumina/dd0aff11-2664-481b-a8ce-26831a907cae/beadscan_3.0_software_addendum.pdf - bpm: - description: A beaded pool manifest. Describe the SNP or probe content on a BeadChip or in an assay pool. - source: https://support.illumina.com/datafiles.html - cel: + - cc-by-nc-sa-2.5 + meaning: https://creativecommons.org/licenses/by-nc-sa/2.5/ + CC BY-NC-SA 2.0: aliases: - - Affymetrix probe raw data format - description: Format of Affymetrix data file of information about (raw) expression levels of the individual probes - meaning: EDAM:format_1638 - chp: + - cc-by-nc-sa-2.0 + meaning: https://creativecommons.org/licenses/by-nc-sa/2.0/ + CC BY-NC-SA 1.0: aliases: - - Affymetrix probe normalised data format - description: CHP file contains probe set analysis results generated from Affymetrix software - meaning: EDAM:format_1644 - dat: + - cc-by-nc-sa-1.0 + meaning: https://creativecommons.org/licenses/by-nc-sa/1.0/ + CC BY-ND: aliases: - - Affymetrix image data file format - description: Format of Affymetrix data file of raw image data. - meaning: EDAM:format_1637 - idat: - description: Proprietary file format for (raw) BeadArray data used by genomewide profiling platforms from Illumina Inc. This format is output directly from the scanner and stores summary intensities for each probe-type on an array. - meaning: EDAM:format_3578 - locs: - description: Illumina iScan bead location file. - source: https://support.illumina.com/content/dam/illumina-support/documents/documentation/system_documentation/iscan/iscan-system-guide-11313539-01.pdf - MassSpecFileFormatEnum: - description: File formats for mass spectrometry data - title: Mass Spectrometry File Format - permissible_values: - msf: + - cc-by-nd + description: 'This license is one of the Creative Commons licenses and allows users to share the dataset if they give credit to copyright holder, but they cannot make any additions, transformations or changes to the dataset under this license.' + source: https://creativecommons.org/licenses/by-nd/4.0/ + title: Creative Commons Attribution-NoDerivatives 4.0 International + CC BY-ND 4.0: aliases: - - Magellan storage file format - description: Proprietary mass-spectrometry format of Thermo Scientific's ProteomeDiscoverer software - meaning: EDAM:format_3702 - mzML: - description: mzML format for raw spectrometer output data, standardised by HUPO PSI MSS. - meaning: EDAM:format_3244 - raw: - description: Proprietary file format for mass spectrometry data from Thermo Scientific - meaning: EDAM:format_3712 - TabularFileFormatEnum: - description: Tabular data formats including spreadsheets and delimited files - title: Tabular File Format - permissible_values: - RCC: - description: Reporter Code Count-A data file (.csv) output by the Nanostring nCounter Digital Analyzer, which contains gene sample information, probe information and probe counts. - meaning: EDAM:format_3580 - csv: + - cc-by-nd-4.0 + meaning: https://creativecommons.org/licenses/by-nd/4.0/ + CC BY-ND 3.0: aliases: - - Comma-separated values - description: Tabular data represented as comma-separated values in a text file - meaning: EDAM:format_3752 - excel: - description: Microsoft Excel spreadsheet format with extension .xlsx or .xls - meaning: EDAM:format_3620 - notes: - - http://edamontology.org/format_3468 is the older version of http://edamontology.org/format_3620 - parquet: - description: An open, columnar table format that stores data by column with built-in compression and schema metadata for fast analytics. - meaning: https://parquet.apache.org/ - tsv: + - cc-by-nd-3.0 + meaning: https://creativecommons.org/licenses/by-nd/3.0/ + CC BY-ND 2.5: aliases: - - Tab-delimited - - Tab-separated values - - tab - description: Tabular data represented as tab-separated values in a text file - meaning: EDAM:format_3475 - ScriptFileFormatEnum: - description: Script and code file formats - title: Script File Format - permissible_values: - MATLAB script: + - cc-by-nd-2.5 + meaning: https://creativecommons.org/licenses/by-nd/2.5/ + CC BY-ND 2.0: aliases: - - MATLAB - - m - description: A MATLAB script file with expected extension “.m”. Note that files with a “.mat” extension contains MATLAB formatted data. - meaning: EDAM:format_4007 - Python script: + - cc-by-nd-2.0 + meaning: https://creativecommons.org/licenses/by-nd/2.0/ + CC BY-ND 1.0: aliases: - - Python - - Python program - - py - description: Python script with expected extension “.py”. - meaning: EDAM:format_3996 - R script: + - cc-by-nd-1.0 + meaning: https://creativecommons.org/licenses/by-nd/1.0/ + CC BY-SA: aliases: - - R - - R program - description: R script with expected extension “.R”. - meaning: EDAM:format_3999 - bash script: - description: Bash shell script with .sh extension. - source: https://en.wikipedia.org/wiki/Shell_script - js: - description: File with Javascript code. - DataFileFormatEnum: - description: Structured data formats for serialization and storage - title: Data File Format - permissible_values: - MATLAB data: + - cc-by-sa + description: 'This license is one of the open Creative Commons licenses and allows users to share and adapt the dataset as long as they give credit to the copyright holder and distribute any additions, transformations or changes to the dataset under this same https://creativecommons.org/licenses/by/4.0/' + source: https://creativecommons.org/licenses/by-nc-sa/4.0/ + title: Creative Commons Attribution-ShareAlike 4.0 International + CC BY-SA 4.0: aliases: - - .mat file format - - MATLAB file format - description: A MATLAB formatted data file with expected extension “.mat”. - meaning: EDAM:format_3626 - RData: - description: The RData format (usually with extension .rdata or .rda) is a format designed for use with R, a system for statistical computation and related graphics, for storing a complete R workspace or selected 'objects' from a workspace in a form that can be loaded back by R. - source: https://www.loc.gov/preservation/digital/formats/fdd/fdd000470.shtml - SDAT: - description: Phillips MRS Data File - source: https://github.com/chenkonturek/MRS_MRI_libs - SPAR: - description: Phillips MRS Header File - source: https://github.com/chenkonturek/MRS_MRI_libs - json: + - cc-by-sa-4.0 + meaning: https://creativecommons.org/licenses/by-sa/4.0/ + CC BY-SA 3.0: aliases: - - JavaScript Object Notation - description: JavaScript Object Notation format; a lightweight, text-based format to represent tree-structured data using key-value pairs. - meaning: EDAM:format_3464 - prism: + - cc-by-sa-3.0 + meaning: https://creativecommons.org/licenses/by-sa/3.0/ + CC BY-SA 2.5: aliases: - - GraphPad Prism file - description: GraphPad Prism native file format (Prism 10+) for storing data tables, graphs, layouts, and analysis results. Uses an open access format leveraging industry standards. - source: https://www.graphpad.com/features - rds: - description: R binary data format similar to RData. - source: https://www.datafiles.samhsa.gov/get-help/format-specific-issues/how-do-i-read-data-r - sqlite: - description: Data format used by the SQLite database. - meaning: EDAM:format_3621 - xml: + - cc-by-sa-2.5 + meaning: https://creativecommons.org/licenses/by-sa/2.5/ + CC BY-SA 2.0: + aliases: + - cc-by-sa-2.0 + meaning: https://creativecommons.org/licenses/by-sa/2.0/ + CC BY-SA 1.0: + aliases: + - cc-by-sa-1.0 + meaning: https://creativecommons.org/licenses/by-sa/1.0/ + CC-0: + aliases: + - cc0 + - cc-zero + - cc-by-+-cc0 + description: A Creative Commons license and is like a public domain dedication. The copyright holder surrenders rights in a dataset using this license. + source: https://creativecommons.org/publicdomain/zero/1.0/ + title: Creative Commons Zero + CC0 1.0: + aliases: + - cc0-1.0 + meaning: https://creativecommons.org/publicdomain/zero/1.0/ + CC-BY: + aliases: + - cc-by + description: This license is one of the open Creative Commons licenses and allows users to share and adapt the dataset so long as they give credit to the copyright holder. + source: https://creativecommons.org/licenses/by/4.0/ + title: Creative Commons Attribution 4.0 International + CC-BY 4.0: + aliases: + - cc-by-4.0 + - cc by 4.0 + meaning: https://creativecommons.org/licenses/by/4.0/ + CC-BY 3.0: aliases: - - eXtensible Markup Language - description: eXtensible Markup Language (XML) format. - meaning: EDAM:format_2332 - yaml: - description: YAML (YAML Ain't Markup Language) is a human-readable tree-structured data serialisation that is a superset of JSON (as of v1.2). - meaning: EDAM:format_3750 - ArchiveFileFormatEnum: - description: Compressed archive and container formats - title: Archive File Format - permissible_values: - 7z: + - cc-by-3.0 + meaning: https://creativecommons.org/licenses/by/3.0/ + CC-BY 2.5: aliases: - - 7Z Compression Format - description: A compressed archive file format that supports several different data compression, encryption and pre-processing filters. - meaning: NCIT:C80224 - docker image: - description: 'A Docker image is a file, comprised of multiple layers, that is used to execute code in a Docker container. An image is essentially built from the instructions for a complete and executable version of an application, which relies on the host OS kernel - -' - meaning: EDAM:format_3973 - gzip: + - cc-by-2.5 + meaning: https://creativecommons.org/licenses/by/2.5/ + CC-BY 2.0: aliases: - - GNU Zip - - gz - description: GZipped format - meaning: EDAM:format_3989 - tar: + - cc-by-2.0 + meaning: https://creativecommons.org/licenses/by/2.0/ + CC-BY 1.0: aliases: - - Tarball - description: TAR archive file format generated by the Unix-based utility tar. - meaning: EDAM:format_3981 - zip: - description: zip is a format standard of a digital entity that is conformant with the PKWARE .ZIP file format specification - meaning: EDAM:format_3987 - DocumentFileFormatEnum: - description: Document and text formats - title: Document File Format - permissible_values: - ai: - description: Adobe Illustrator format - meaning: SWO:3000023 - doc: + - cc-by-1.0 + meaning: https://creativecommons.org/licenses/by/1.0/ + ODC-BY: aliases: - - Microsoft Word format - description: Microsoft Word document format - meaning: EDAM:format_3506 - html: + - odc-by + description: This license is one of the Open Data Commons licenses and allows users to share and adapt the dataset as long as they give credit to the copyright holder. + source: https://opendatacommons.org/licenses/by/ + title: Open Data Commons Attribution License + ODC-BY 1.0: aliases: - - Hypertext Markup Language - description: HTML format - meaning: EDAM:format_2331 - hyperlink: + - odc-by-1.0 + meaning: https://opendatacommons.org/licenses/by/1-0/ + ODC-ODbL: aliases: - - Link - - www-links - description: A reference (link) from some point in one hypertext document to another document, another place in the same document, or a website. - meaning: NCIT:C47919 - md: - description: Markdown (MD) is a lightweight markup language with plain text formatting syntax - notes: - - Strangely, EDAM has [R markdown](http://edamontology.org/format_4000) but not markdown - source: https://en.wikipedia.org/wiki/Markdown - pdf: - description: Portable Document Format - meaning: EDAM:format_3508 - powerpoint: - description: Microsoft Powerpoint slide format - meaning: EDAM:format_3838 - txt: - description: Textual format - meaning: EDAM:format_2330 - OtherFileFormatEnum: - description: Other specialized file formats - title: Other File Format - permissible_values: - MPEG-4: + - odc-odbl + description: 'This license is one of the Open Data Commons licenses and allows users to share and adapt the dataset as long as they give credit to the copyright holder and distribute any additions, transformation or changes to the dataset.' + source: https://opendatacommons.org/licenses/odbl/ + title: Open Data Commons Open Database License + ODC-ODbL 1.0: aliases: - - MP4 - description: A digital multimedia container format most commonly used to store video and audio. - meaning: EDAM:format_3997 - ab1: - description: TAB1 binary format of raw DNA sequence reads (output of Applied Biosystems' sequencing analysis software). Contains an electropherogram and the DNA base sequence. - meaning: EDAM:format_3000 - abf: - description: The Axon Binary File format (ABF) was created for the storage of binary experimental data. - source: https://mdc.custhelp.com/euf/assets/content/ABFHelp.pdf - dna: - description: Propietary SnapGene file format. - source: https://www.snapgene.com/guides/convert-genbank-files - edat3: - description: The .edat3 proprietary format is used to store experiment data that can be analyzed in E-DataAid. - source: https://support.pstnet.com/hc/en-us/articles/229354727-INFO-E-Prime-file-extensions-18091 - fcs: - description: Format standard of a digital entity that is conformant with the Flow Cytometry Data File Standard - meaning: OBI:0000327 - fig: - description: Line drawing saved in the Xfig format; stored as a vector image that may include lines, shapes, arcs, splines, arrows, and text objects; may also include images, colors, and patterns. - source: https://fileinfo.com/extension/fig - gb: - description: GenBank Sequence Format (GenBank Flat File Format) consists of an annotation section and a sequence section. The start of the annotation section is marked by a line beginning with the word "LOCUS". The start of sequence section is marked by a line beginning with the word "ORIGIN" and the end of the section is marked by a line with only "//". - meaning: EDAM:format_1936 - source: https://fairsharing.org/833 - hdf5: + - odc-odbl-1.0 + meaning: https://opendatacommons.org/licenses/odbl/1-0/ + ODC-PDDL: aliases: - - h5 - description: 'HDF5 is the new version, according to the HDF group, a completely different technology (https://support.hdfgroup.org/products/hdf4/ compared to HDF. An HDF5 file appears to the user as a directed graph. The nodes of this graph are the higher-level HDF5 objects that are exposed by the HDF5 APIs: Groups, Datasets, Named datatypes. Currently supported by the Python MDTraj package. HDF5 is a data model, library, and file format for storing and managing data, based on Hierarchical Data Format (HDF). - -' - meaning: EDAM:format_3590 - notes: - - This file format encompasses/includes the h5ad anndata format commonly used for scRNAseq data sharing. - idx: - description: '' - psydat: - description: TrialHandler or StairHandler object that has been saved to disk with the python cPickle module, ideal for batch analysis and plotting with Python. - notes: - - Not in EDAM as of April 2024. - source: https://www.psychopy.org/general/dataOutputs.html - pzfx: - description: Legacy GraphPad Prism XML file format (Prism 5-9) for storing project data including graphs, layouts, notes, and tables. Superseded by the .prism format in Prism 10+. - source: https://fileinfo.com/extension/pzfx - rmd: - description: Markdown document specific to R analyses. - meaning: EDAM:format_4000 - source: http://rmarkdown.rstudio.com/developer_document_templates.html - sav: - description: The SPSS Statistics File Format is a proprietary binary format, developed and maintained as the native format for the SPSS statistical software application. - source: https://www.loc.gov/preservation/digital/formats/fdd/fdd000469.shtml - sdf: - description: SDF is one of a family of chemical-data file formats developed by MDL Information Systems; it is intended especially for structural information. - meaning: EDAM:format_3814 - sif: - description: SIF (simple interaction file) Format - a network/pathway format used for instance in cytoscape - meaning: EDAM:format_3619 - svg: + - odc-pddl + description: 'This license is one of the Open Data Commons licenses and is like a public domain dedication. The copyright holder surrenders rights in a dataset using this license.' + source: https://opendatacommons.org/licenses/pddl/ + title: Open Data Commons Public Domain Dedication and License + ODC-PDDL 1.0: aliases: - - Scalable Vector Graphics - description: Scalable Vector Graphics (SVG) is an XML-based vector image format for two-dimensional graphics with support for interactivity and animation. - meaning: EDAM:format_3604 - CuratedDataEnum: - permissible_values: - chemical descriptor: - description: A chemical descriptor is a data item (quantity or value) about a chemical entity that conforms to a specification for how it is calculated, measured or recorded. - meaning: CHEMINF:000123 - clinical data: + - odc-pddl-1.0 + meaning: https://opendatacommons.org/licenses/pddl/1-0/ + Public Domain: aliases: - - Clinical - description: Data obtained through patient examination or treatment. - meaning: NCIT:C15783 - gene function: - description: A term that expresses the function of a gene product. - meaning: NCIT:C48933 - gene symbol: + - public domain + - publicdomain + description: Technically not a license, the public domain mark relinquishes all rights to a dataset and dedicates the dataset to the public domain. + source: https://creativecommons.org/public-domain/pdm/ + UNKNOWN: aliases: - - Gene Name - - Official Gene Name - - gene - description: A unique gene name approved by an organism specific nomenclature committee. - meaning: NCIT:C43568 - Resource: - description: 'Resource classes. Most resource entities expected to be some type of "experimental data" and further specified via `dataType`. - -' + - notspecified + - other-open + - other-closed + - restricted-access + description: The license for the dataset is not known. + ManifestationEnum: permissible_values: - experimentalData: - description: Any file derived from or pertaining to a scientific experiment. Experimental data annotations should be applied, possibly disease-related. - metadata: - description: Data about data, information that describes another set of data. - meaning: NCIT:C52095 - protocol: - description: A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process. - meaning: OBI:0000272 - report: + Atypical Neurofibroma: aliases: - - Document - - Record - description: 'A document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record). - -' - meaning: IAO:0000088 - result: - comments: This resource category is somewhat more general than `report`. - description: Any file that reports data results. Examples include figures, presentations, analysis, etc. - source: https://synapse.org - tool: - description: Any file or link that represents a tool, model, or algorithm; the tool annotations could be applied - source: https://synapse.org - weblink: + - Ancient Neurofibroma + - Neurofibroma with Atypia + Atypical Neurofibromatous Neoplasm with Uncertain Biologic Potential (ANNUBP): + Behavioral: + Breast Cancer: + Cognition: + Cutaneous Neurofibroma: aliases: - - URL - - Uniform Resource Locator - description: An address to another document or other resource on the World Wide Web. - meaning: NCIT:C42743 - workflow report: - description: Workflow-generated reports of analysis of primary data, usually created programmatically at completion of workflow step. + - Dermal Neurofibroma + Glioma: + aliases: + - glial neoplasm + - glial tumor + - neoplasm of neuroglia + - neuroglial neoplasm + - neuroglial tumor + - tumor of neuroglia + - tumour of the neuroglia + High-Grade Glioma: + Juvenile Myelomonocytic Leukemia (JMML): + Low-Grade Glioma: + Malignant Peripheral Nerve Sheath Tumor (MPNST): + Memory: + Meningioma: + Pain: + Plexiform Neurofibroma: + Quality of Life: + Schwannoma: + Spinal Meningioma (SMN): + Vision Loss: + StudyStatusEnum: + permissible_values: + Active: + description: The project is in the performance period between grant start and grant end dates. + Completed: + description: The project has reached the grant end date and all intended data has been generated and uploaded. + Withdrawn: + description: The project was planned/started but not completed (withdrawn for various reasons). + title: Study Status AntibodyEnum: permissible_values: "Anti-Human NF1 Monoclonal Antibody, Unconjugated, Clone 3F3": @@ -5565,331 +5580,330 @@ enums: meaning: AnimalModel: permissible_values: - "129-Nf1/Nci": - description: "Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58b28d42-aa4f-496f-be70-257e8d1a95c6" - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+": - description: "Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b8b5bd4-a085-4788-ae0e-dadf5def4b8b" - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-": - description: "Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d59c28f-a132-4b3c-a52e-31da039647ca" - "B6-129S4-Nf1-/+;Trp53-/+cis": - description: "B6X129S4 F1 hybrid" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9474c772-2e68-4f02-b0c8-f962f731d175" - "B6.129(Cg)-Nf1tm1Par/J": - description: "[From JAX]: These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I." + NF1flox4/Arg681*;Dhh-Cre: + description: '[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) AND NF1 exon 4 floxed allele. Dhh-Cre induces inactivation of NF1 flox allele in glial lineage cells beginning at E12.5' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=033b7173-4c58-410e-b441-579ba05c388a + Nf1tm1d(KOMP)Wtsi: + description: '[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination.' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ecabd72-d36c-487e-8c0e-c05e3dd743ba + B6.129(Cg)-Nf1tm1Par/J: + description: '[From JAX]: These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I.' meaning: rrid:IMSR_JAX:017640 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118aa95e-27f4-48fa-94c7-5f786b8b4f2f" - "B6.129S1-Nf1tm1Cbr/J": - description: "[From JAX]: Mice homozygous for this targeted allele (Nf123a-/-) lack the alternatively spliced exon 23a (which modifies the GTPase-activating protein (GAP) domain of Nf1). These mutant mice may be useful for neurological studies of Neurofibromatosis Type I, growth, differentiation, and learning and memory." - meaning: rrid:IMSR_JAX:007923 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=893695cf-daa7-42eb-998c-9b04af941964" - "B6.129S2-Nf1tm1Tyj/J": - description: "[From JAX]: Heterozygous animals do not exhibit the classical symptoms of Human neurofibromatosis type 1, but are highly predisposed to the formation of various tumor types, notably phaeochromocytoma, a tumor of the neural crest-derived adrenal medulla, and myeloid leukemia. Homozygosity leads to abnormal cardiac development and mid-gestational embryonic lethality. This strain may be useful in studies of cancer and developmental biology." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118aa95e-27f4-48fa-94c7-5f786b8b4f2f + Nf1pArg1947mp1: + description: '[From GFF:] Minipig model containing a recurrent nonsense mutation p.Arg1947*(R1947*) and HindIII RFLP site resulting in frame shift mutation' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=209c16d7-c1fa-414f-8f08-458eaefc2259 + Nf1tm1c(KOMP)Wtsi: + description: '[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele.' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=361988eb-d390-4f40-b01b-acee637e2271 + B6.129S2-Nf1tm1Tyj/J: + description: '[From JAX]: Heterozygous animals do not exhibit the classical symptoms of Human neurofibromatosis type 1, but are highly predisposed to the formation of various tumor types, notably phaeochromocytoma, a tumor of the neural crest-derived adrenal medulla, and myeloid leukemia. Homozygosity leads to abnormal cardiac development and mid-gestational embryonic lethality. This strain may be useful in studies of cancer and developmental biology.' meaning: rrid:IMSR_JAX:008192 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45638793-f2d0-4c40-8b1c-be1f1b0c0f93" - "B6.129S6-Nf1/Nci": - description: "Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f9ca98a1-b5c5-423c-a4bd-db143975aa1c" - "B6.129S6-Nf1tm1Fcr/J": - description: "[From GFF:] GEM mouse in which Exon 31 of Nf1 has been disrupted in one allele" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45638793-f2d0-4c40-8b1c-be1f1b0c0f93 + B6.129S6-Nf1tm1Fcr/J: + description: '[From GFF:] GEM mouse in which Exon 31 of Nf1 has been disrupted in one allele' meaning: rrid:IMSR_JAX:002646 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a0ccbed-abcd-49fa-abd0-5ff7b275a1e1" - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J": - description: "EllaCre driver line." - meaning: rrid:IMSR_JAX:003724 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5511a019-88aa-43c8-86c3-ad1677c8a3d0" - "B6/JGpt-Nf1/Gpt": - description: "Conditional knockout" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27c1a639-9e98-4289-872d-f275d4e49be7" - "B6/JGpt-Nf1/Gpt": - description: Knockout - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a067f136-f956-4355-a76f-a5eec7c196f0" - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ": - description: "[From JAX]: These NPS+/- mice carry Trp53, Nf1, and Suz12 mutations on chromosome 11 (in cis) and develop high-grade gliomas and malignant peripheral nerve sheath tumors by approximately 3.5 months. They are suitable for use in applications related to the study of neurofibromatosis type 1 and tumor suppressor genes." - meaning: rrid:IMSR_JAX:027678 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9b2d8ba-de9f-4bca-9401-fe100024deba" - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J": - description: "[From JAX]: These mice carry Trp53 and Nf1 targeted mutations on the same homolog of chromosome 11 (in cis). These mutations are approximately 10 Mbp apart and may segregate independently of one another. Double heterozygotes survive an average of five months and exhibit a significant increase in the percentage of soft tissue sarcomas. About 30% of tumors from the Nf1/Trp53 cis animals stain positively for S100 (consistent with glial cell origin) and exhibit classic histological features of malignant peripheral nerve sheath tumors (MPNSTs). This strain may be useful in studies of astrocytomas/glioblastomas and tumor suppressor genes." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a0ccbed-abcd-49fa-abd0-5ff7b275a1e1 + Nf1tm1.1Kest: + description: '[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) was introduced in exon 18 and a FRT-flanked neomycin selection cassette was inserted in intron 17. Flp-mediated recombination removed the selection cassette.' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504d7dfe-acf9-476c-974d-e8665095afbb + B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J: + description: '[From JAX]: These mice carry Trp53 and Nf1 targeted mutations on the same homolog of chromosome 11 (in cis). These mutations are approximately 10 Mbp apart and may segregate independently of one another. Double heterozygotes survive an average of five months and exhibit a significant increase in the percentage of soft tissue sarcomas. About 30% of tumors from the Nf1/Trp53 cis animals stain positively for S100 (consistent with glial cell origin) and exhibit classic histological features of malignant peripheral nerve sheath tumors (MPNSTs). This strain may be useful in studies of astrocytomas/glioblastomas and tumor suppressor genes.' meaning: rrid:IMSR_JAX:008191 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d71c2b4-a7c5-4ced-bb45-eb98bfe42025" - "B6;CBA-Nf1/Flmg": - description: "Mice with a mutated (possibly truncated) Nf1 protein were generated using CRISPR/Cas9 technology. The mutated protein is the result of a single nucleotide deletion that takes place at exon 38 close to the targeted mutated R1809C position. A guide sgRNA along with the wild-type Cas9 protein were introduced into mouse zygotes via pronuclear microinjections." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=618a2f93-b45d-45bb-85f5-4a06929d5d8c" - "C3HeB/FeJ-Nf1/Ieg": - description: "Induced Mutant Strain: Chemically-induced" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=af2241b2-2d00-476c-bfd1-e4ebf3a99ce6" - "C57BL/6-Nf1/Mmjax": - description: "carry an R1276P missense allele" - meaning: "rrid:MMRRC_041154-JAX" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b167141d-be0c-4f87-b767-956b24161b9c" - "C57BL/6JSmoc-Nf1em1Smoc": - description: "Exon 21-23 of Nf1 gene was deleted to generate Nf1 knockout mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d8c40468-ae43-4982-b079-5ff5e8ae104e" - "C57BL/6JSmoc-Nf1tm1(flox)Smoc": - description: "These mice carry loxP sites flanking exon 31-32 of Nf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf1 gene." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ddf3618d-dda5-4c03-a4b4-b9263dba0a31" - "C57BL/6N-Nf1/Mmucd": - description: "ES cell clone EPD0033_1_F12 was injected into morulae or blastocysts. Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1a (Knockout First) animals were generated." - meaning: "rrid:MMRRC_048792-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2610c4cd-d622-4393-9087-0b007fa0567b" - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+": - description: "Transgenic mouse expressing oncogenic N-ras specifically in central nerve cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06545c3d-e098-4a67-a678-6f023fda6b88" - "CisNf1+/-; p53+/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27b4443a-06bb-454f-a253-ffb60b70a129" - "Cnp-EGFR (Pten-het/C-EGFR)": - description: "EGFR overexpression in Schwann cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2934805f-67ef-41d9-af89-64a072c66642" - "Cnp-EGFR (deltaPten/C-EGFR)": - description: "EGFR overexpression in Schwann cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98e86631-5d93-4b4a-862a-d2758420674a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d71c2b4-a7c5-4ced-bb45-eb98bfe42025 + Nf14F/4F;CAGGCre-ERTM: + description: '[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844c4e22-6d4d-454b-9ee4-53dcc7435e43 + B6.129S1-Nf1tm1Cbr/J: + description: '[From JAX]: Mice homozygous for this targeted allele (Nf123a-/-) lack the alternatively spliced exon 23a (which modifies the GTPase-activating protein (GAP) domain of Nf1). These mutant mice may be useful for neurological studies of Neurofibromatosis Type I, growth, differentiation, and learning and memory.' + meaning: rrid:IMSR_JAX:007923 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=893695cf-daa7-42eb-998c-9b04af941964 + Nf1tm2.1Kest: + description: '[From GFF:]  A point mutation, recapitulating the human missense variant c.2542G>C, in which a glycine residue at position 848 was changed to an arginine (p.Gly848Arg), was introduced in exon 21 and a FRT-flanked neomycin selection cassette was inserted in intron 20. Flp-mediated recombination removed the selection cassette. ' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e5c372e-dec8-4693-98a8-b07f3014257d + NF1SynIKO: + description: '[From GFF:] GEM mouse in which Nf1 is knocked out in neurons' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90c10d9a-c560-4722-8cbb-0e424bd417b7 + Nf1+/-GFAPCKO: + description: '[From GFF:] Mice heterozygous for a germ-line inactivating Nf1 mutation and a conditional knock-out of NF1 in astrocytes' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9971e47e-976a-4631-8edd-5cae04304b01 + B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ: + description: '[From JAX]: These NPS+/- mice carry Trp53, Nf1, and Suz12 mutations on chromosome 11 (in cis) and develop high-grade gliomas and malignant peripheral nerve sheath tumors by approximately 3.5 months. They are suitable for use in applications related to the study of neurofibromatosis type 1 and tumor suppressor genes.' + meaning: rrid:IMSR_JAX:027678 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9b2d8ba-de9f-4bca-9401-fe100024deba + NF1fl/fl;Dhh-Cre: + description: '[From GFF:] Mice with inactivation of NF1 in glial lineage cells beginning at E12.5' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bfa7ccaa-fee4-42bd-bc74-afe859d56fb6 + NCC-MPNST3-X2: + description: A patient-derived xenograft model created using the NCC-MPNST3-C1 cell line. This xenograft model was used to generate the NCC-MPNST3-X2-C1 cell line. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8a807e4-502b-461c-a60f-fd10b3cde70e + Nf14F/Arg681*: + description: 'Cre-negative Nf14F/Arg681*' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2a0345f-f0ba-4d72-99d7-f9ad2ea77751 + Nf1flox/-;hGFAP-Cre: + description: '[From GFF:] Mice heterozygous for a germ-line Ex31-32 Nf1 mutation and a conditional knock-out of NF1 in astrocytes' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbf11ec4-1d12-4feb-a6fc-9faf6bc9c9db + 129-Nf1/Nci: + description: Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58b28d42-aa4f-496f-be70-257e8d1a95c6 + B6.129S6-Nf1/Nci: + description: Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f9ca98a1-b5c5-423c-a4bd-db143975aa1c + B6/JGpt-Nf1/Gpt: + description: Conditional knockout + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27c1a639-9e98-4289-872d-f275d4e49be7 + B6/JGpt-Nf1/Gpt: + description: Knockout + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a067f136-f956-4355-a76f-a5eec7c196f0 + B6;CBA-Nf1/Flmg: + description: Mice with a mutated (possibly truncated) Nf1 protein were generated using CRISPR/Cas9 technology. The mutated protein is the result of a single nucleotide deletion that takes place at exon 38 close to the targeted mutated R1809C position. A guide sgRNA along with the wild-type Cas9 protein were introduced into mouse zygotes via pronuclear microinjections. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=618a2f93-b45d-45bb-85f5-4a06929d5d8c + C3HeB/FeJ-Nf1/Ieg: + description: 'Induced Mutant Strain: Chemically-induced' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=af2241b2-2d00-476c-bfd1-e4ebf3a99ce6 + C57BL/6JSmoc-Nf1em1Smoc: + description: Exon 21-23 of Nf1 gene was deleted to generate Nf1 knockout mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d8c40468-ae43-4982-b079-5ff5e8ae104e + C57BL/6JSmoc-Nf1tm1(flox)Smoc: + description: These mice carry loxP sites flanking exon 31-32 of Nf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf1 gene. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ddf3618d-dda5-4c03-a4b4-b9263dba0a31 + C57BL/6-Nf1/Mmjax: + description: carry an R1276P missense allele + meaning: rrid:MMRRC_041154-JAX + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b167141d-be0c-4f87-b767-956b24161b9c + C57BL/6N-Nf1/Mmucd: + description: ES cell clone EPD0033_1_F12 was injected into morulae or blastocysts. Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1a (Knockout First) animals were generated. + meaning: rrid:MMRRC_048792-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2610c4cd-d622-4393-9087-0b007fa0567b + Nf1adelta5 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e7a8732a-73ba-4d05-88a9-8d796d0f1a6b + Nf1b+10 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d5e90cc-e97a-4321-b0a5-82feed840c50 + Nf1flox/mut; GFAP-Cre: + description: NF1 conditional knock out + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4e513b5b-dde9-424d-96ff-3dd7c90f429b + Nf1-/+;Trp53-/+cis: + description: Nf1-/+;Trp53-/+ cis on mouse chromosome 11 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=426a3531-5785-4972-83ad-d88e54d2ef7f + Nf1flox/flox: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2dec4d7-24be-4218-b7b5-63349158aa15 + Nf1-/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b705a9f5-84ef-404e-9fe4-d499550298b3 + Nf1+/-: + description: heterozygous Nf1 mutant + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d27fd7b0-ed8f-4ee2-a8d9-26748c12518c + Nf1flox/-: + description: Nf1+/- mouse + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbeb0bb9-5341-496c-991a-de1e84af09b5 + 129T2/SvEmsJ::C57Bl/6NTac Nf1+/-: + description: Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d59c28f-a132-4b3c-a52e-31da039647ca + 129T2/SvEmsJ::C57Bl/6NTac Nf1+/+: + description: Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b8b5bd4-a085-4788-ae0e-dadf5def4b8b + B6-129S4-Nf1-/+;Trp53-/+cis: + description: B6X129S4 F1 hybrid + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9474c772-2e68-4f02-b0c8-f962f731d175 + CisNf1+/-; p53+/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27b4443a-06bb-454f-a253-ffb60b70a129 + Cnp-EGFR (deltaPten/C-EGFR): + description: EGFR overexpression in Schwann cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98e86631-5d93-4b4a-862a-d2758420674a + Cnp-EGFR (Pten-het/C-EGFR): + description: EGFR overexpression in Schwann cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2934805f-67ef-41d9-af89-64a072c66642 Cre(Col2.3Cre): - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19f93a61-f847-4479-ba8d-8b8a1cb3184b" - "Cx3cr1+/gfp": - description: "wild-type mouse with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaf6e2b6-2e88-4ed1-8bfc-9b803ba2d718" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19f93a61-f847-4479-ba8d-8b8a1cb3184b + Cx3cr1+/gfp: + description: wild-type mouse with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaf6e2b6-2e88-4ed1-8bfc-9b803ba2d718 DelE17: - description: "homozygous deletion of NF1 exon 17" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e00317c8-ff2c-453b-9d71-c8bf3f50a600" - "Dhh-Cre; Nf1flox/+; Ptenflox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d50930bc-c261-41a6-b517-548516044526" - "Dhh-Cre; Nf1flox/+; Ptenflox/flox": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=667881c8-e235-4d82-84af-2d1be9c6ef9b" - "Dhh-Cre; Nf1flox/flox; Ptenflox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=caa4c07e-89d1-490d-a2a8-f63bf69bc5d3" - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=507595f1-9243-48d9-bc56-e9a97904789b" - "Dhh-Cre; Ptenflox/+": - description: "Conditional Inactivation of Pten" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc6bf003-6330-4fc9-b851-8c6a3ada5d79" - "Dhh-Cre; Ptenflox/flox": - description: "Conditional Inactivation of Pten" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8941ec-d5c8-42ae-9c1b-bc4066177ec3" - "Krox20;Nf1flox/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6f865b65-5995-4243-8832-b8120fd2c36f" - "MPNST-Nf1-001": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=558a480a-0a0c-4e81-8735-2f90c7126bb0" - "MPNST-Nf1-002": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bcb3c61f-9f6d-4f04-8d5d-3ea1b63843a6" - "MPNST-Nf1-S462": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f587995-9831-4d51-99a3-a51b7607e83a" - "MPNST-SP-001": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41c369b5-25f3-4285-829f-5481b41b230e" - "MPSNT-SP-002": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2cc7762-5e1a-45d6-a4ce-029be9b42094" - "NCC-MPNST3-X2": - description: "A patient-derived xenograft model created using the NCC-MPNST3-C1 cell line. This xenograft model was used to generate the NCC-MPNST3-X2-C1 cell line." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8a807e4-502b-461c-a60f-fd10b3cde70e" - NF1SynIKO: - description: "[From GFF:] GEM mouse in which Nf1 is knocked out in neurons" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90c10d9a-c560-4722-8cbb-0e424bd417b7" - "NF1fl/fl;Dhh-Cre": - description: "[From GFF:] Mice with inactivation of NF1 in glial lineage cells beginning at E12.5" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bfa7ccaa-fee4-42bd-bc74-afe859d56fb6" - "NF1flox4/Arg681*;Dhh-Cre": - description: "[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) AND NF1 exon 4 floxed allele. Dhh-Cre induces inactivation of NF1 flox allele in glial lineage cells beginning at E12.5" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=033b7173-4c58-410e-b441-579ba05c388a" - "Nf1 +/Δ4": - description: "Mice harboring a null allele resulting from exon 4 deletion were created by breeding Nf1+/4F mice to an EIIaCre driver line (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J)." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9933922-29fb-4a4c-bc5f-604691a8bab7" - "Nf1 Arg681*/Arg681*": - description: "Created by breeding Nf1 +/Arg681* (Nf1tm1.1Kest), is embryonic lethal at day 9.5." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91e9130d-00bc-4dfe-9a5d-356e5ae3f4db" - "Nf1 GEM": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b07051a7-b584-45ae-82ad-f7bb85c1dea5" - "Nf1 Ocl-/-": - description: "Nf1-deficient osteoclasts in otherwise Nf1+/+ background" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09880210-fe90-4af9-8b1f-f886348a34eb" - "Nf1 flox/+; DhhCre/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6159b19a-c94f-4001-887f-778a8fb1e685" - "Nf1 heterozygous mutant minipig": - description: "heterozygous mutations in NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02aba952-5860-4bd9-bfb2-ff796b22bf48" - "Nf1 Δ4/Δ4": - description: "Created by breeding Nf1 +/Δ4, is embryonic lethal at day 9.5." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8984594-d5ff-4827-8e83-13ccbf0055e8" + description: homozygous deletion of NF1 exon 17 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e00317c8-ff2c-453b-9d71-c8bf3f50a600 + delta-ira1 delta-ira2 yeast: + description: delta-ira1 delta-ira2 double-knockout yeast + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b2a7ee1-e462-42b9-80b8-0a64ca60b091 + Dhh-Cre; Nf1flox/+; Ptenflox/flox: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=667881c8-e235-4d82-84af-2d1be9c6ef9b + Dhh-Cre; Ptenflox/+: + description: Conditional Inactivation of Pten + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc6bf003-6330-4fc9-b851-8c6a3ada5d79 + Dhh-Cre; Ptenflox/flox: + description: Conditional Inactivation of Pten + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8941ec-d5c8-42ae-9c1b-bc4066177ec3 + Dhh-Cre; Nf1flox/flox; Ptenflox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=caa4c07e-89d1-490d-a2a8-f63bf69bc5d3 + Dhh-Cre; Nf1flox/flox; Ptenflox/flox: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=507595f1-9243-48d9-bc56-e9a97904789b + dNf1 Drosophila: + description: Homozygous dNf1 null mutants + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7b76ccd-e646-4d30-8868-ba39541dd573 + Krox20;Nf1flox/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6f865b65-5995-4243-8832-b8120fd2c36f + miR-155 -/-;Nf1flox/flox ;DhhCre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6e61b912-8006-48cb-a122-df613c8921c4 + miR-155 +/-;Nf1flox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2470d9dd-b6c8-4cdb-ad2e-009071477c41 + miR-155 +/-;Nf1flox/+;DhhCre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a79e9847-1e32-41c8-a176-adf96a8547c0 + MPNST-Nf1-001: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=558a480a-0a0c-4e81-8735-2f90c7126bb0 + MPNST-Nf1-002: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bcb3c61f-9f6d-4f04-8d5d-3ea1b63843a6 + MPNST-Nf1-S462: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f587995-9831-4d51-99a3-a51b7607e83a + MPNST-SP-001: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41c369b5-25f3-4285-829f-5481b41b230e + MPSNT-SP-002: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2cc7762-5e1a-45d6-a4ce-029be9b42094 + Nf1 flox/+; DhhCre/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6159b19a-c94f-4001-887f-778a8fb1e685 + Nf1 heterozygous mutant minipig: + description: heterozygous mutations in NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02aba952-5860-4bd9-bfb2-ff796b22bf48 + Nf1P1/Nf1E1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=326557dc-c320-4f04-b64a-08edd703ee95 + Nf1 GEM: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b07051a7-b584-45ae-82ad-f7bb85c1dea5 Nf1(31): - description: "C57BL/6J mice with a targeted NF1 gene disruption mutation at exon 31 to mimic human NF1 mutations, knockout mutation of Nfl" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e104ac3-b954-4afa-8d87-60c3b1d80b73" - "Nf1+/-": - description: "heterozygous Nf1 mutant" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d27fd7b0-ed8f-4ee2-a8d9-26748c12518c" - "Nf1+/- P53+/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9194d4de-84b2-438a-af6e-6cdfe79ff8cb" - "Nf1+/-GFAPCKO": - description: "[From GFF:] Mice heterozygous for a germ-line inactivating Nf1 mutation and a conditional knock-out of NF1 in astrocytes" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9971e47e-976a-4631-8edd-5cae04304b01" - "Nf1+/-x129S2/SvHsd": - description: "one nf1 allele is deleted" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed66f5fd-52fd-4e83-8442-90b0676cf694" - "Nf1+/Arg681": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118cc6d8-b656-4d6a-9cff-83f2ad92e2b0" - "Nf1+/R681X": - description: "harbored a NF1-patient-derived Nf1 gene mutation (c.2041C>T;p.R681X)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8b964052-b74b-4ca3-ad82-31bd2f3457aa" - "Nf1+/ex42del pig": - description: "heterozygotic mutation in NF1 (exon 42 deletion)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57625a6e-c039-418e-8e22-db464f8aa827" - "Nf1+/Δ4": - description: "Heterozygous mice harboring a null allele resulting from exon 4 deletion" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3013cfbf-07fd-448e-8c57-cf25223eb0b4" - "Nf1-/+;Trp53-/+cis": - description: "Nf1-/+;Trp53-/+ cis on mouse chromosome 11" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=426a3531-5785-4972-83ad-d88e54d2ef7f" - "Nf1-/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b705a9f5-84ef-404e-9fe4-d499550298b3" - "Nf1-/- Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=500a5c2f-5104-405e-a243-3d85b59d6b08" - "Nf1-/-MyoD": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02afeba7-05c6-48b1-9454-efe73d9b21f2" - "Nf14F/4F; DhhCre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb4aff73-9da2-42b5-8f94-0a6084db75b0" - "Nf14F/4F;CAGGCre-ERTM": - description: "[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844c4e22-6d4d-454b-9ee4-53dcc7435e43" - "Nf14F/Arg681*": - description: "Cre-negative Nf14F/Arg681*" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2a0345f-f0ba-4d72-99d7-f9ad2ea77751" - "Nf14F/Arg681*;CAGGCre-ERTM": - description: "[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e70947db-35d1-448b-90d8-ec6f14e70303" + description: C57BL/6J mice with a targeted NF1 gene disruption mutation at exon 31 to mimic human NF1 mutations, knockout mutation of Nfl + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e104ac3-b954-4afa-8d87-60c3b1d80b73 + Nf1-/- Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=500a5c2f-5104-405e-a243-3d85b59d6b08 + Nf1-/-MyoD: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02afeba7-05c6-48b1-9454-efe73d9b21f2 Nf1:p53: - description: "Nf1:p53 mouse tumor model" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8500990a-8848-413c-9c5b-7697d697fa2e" - "Nf1Dsk9/+": - description: "Maintained on a mixed (C3HeB/FeJ x C57bl/6) background" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45756c39-61e8-48b6-ab0c-8f9ce9ad668a" - "Nf1E1 Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=52351388-ba1f-4cf8-a03a-23b941d4408e" + description: Nf1:p53 mouse tumor model + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8500990a-8848-413c-9c5b-7697d697fa2e + Nf1+/- P53+/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9194d4de-84b2-438a-af6e-6cdfe79ff8cb + Nf1+/-x129S2/SvHsd: + description: one nf1 allele is deleted + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed66f5fd-52fd-4e83-8442-90b0676cf694 + Nf1+/Arg681: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118cc6d8-b656-4d6a-9cff-83f2ad92e2b0 + Nf1+/ex42del pig: + description: heterozygotic mutation in NF1 (exon 42 deletion) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57625a6e-c039-418e-8e22-db464f8aa827 + Nf1+/R681X: + description: harbored a NF1-patient-derived Nf1 gene mutation (c.2041C>T;p.R681X) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8b964052-b74b-4ca3-ad82-31bd2f3457aa + Nf14F/4F; DhhCre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb4aff73-9da2-42b5-8f94-0a6084db75b0 + Nf1+/Δ4: + description: Heterozygous mice harboring a null allele resulting from exon 4 deletion + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3013cfbf-07fd-448e-8c57-cf25223eb0b4 + Nf1a+/-; Nf1b-/-; p53m/m zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9cf037b-1743-4eef-88ff-8a80659323eb + Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3a1e3de-577d-4b4b-9eed-91dc21c1bbde + Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=757bf9d9-cf3c-400e-b470-d65302d22897 + Nf1adelta8 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=89b2f63c-1538-468e-9ca1-7ff948cb354e + Nf1aL1247X zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cbc2b84-509f-44c6-b4f2-b77731ca34ef + Nf1bdelta55 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3853fe16-e6fe-4520-8e53-9845c1679fbf + Nf1Dsk9/+: + description: Maintained on a mixed (C3HeB/FeJ x C57bl/6) background + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45756c39-61e8-48b6-ab0c-8f9ce9ad668a + Nf1E1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=52351388-ba1f-4cf8-a03a-23b941d4408e Nf1Fcr: - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05c510fc-2ffc-457f-ba62-679c91799800" - "Nf1Gly848Arg/Gly848Arg": - description: "Homozygous for missense c.2542G>C; p.Gly848Arg mutation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4dfc91c9-31f4-4b00-a95e-4f1b26307339" - "Nf1P1 Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc95a39a-5f41-4d34-9c0c-f312028aa2f3" - "Nf1P1/Nf1E1 Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=326557dc-c320-4f04-b64a-08edd703ee95" - "Nf1Prx1-/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a66bcb2-e137-4471-8cee-29dd9655b276" - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=757bf9d9-cf3c-400e-b470-d65302d22897" - "Nf1a+/-; Nf1b-/-; p53m/m zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9cf037b-1743-4eef-88ff-8a80659323eb" - "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3a1e3de-577d-4b4b-9eed-91dc21c1bbde" - "Nf1aL1247X zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cbc2b84-509f-44c6-b4f2-b77731ca34ef" - "Nf1adelta5 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e7a8732a-73ba-4d05-88a9-8d796d0f1a6b" - "Nf1adelta8 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=89b2f63c-1538-468e-9ca1-7ff948cb354e" - "Nf1b+10 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d5e90cc-e97a-4321-b0a5-82feed840c50" - "Nf1bdelta55 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3853fe16-e6fe-4520-8e53-9845c1679fbf" - "Nf1flox/+;P0A-Cre(+)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ed9ea80-e1fe-4224-bd67-594d9d0b0c7e" - "Nf1flox/-": - description: "Nf1+/- mouse" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbeb0bb9-5341-496c-991a-de1e84af09b5" - "Nf1flox/-; GFAP-Cre; CD11b-TK": - description: "Optic glioma mice with monocyte thymidine kinase expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d1c0c790-acff-486a-b794-b0429b09eeec" - "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp": - description: "Optic glioma mice with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e487fd33-48d3-4a02-b2e0-4d0525ee8e20" - "Nf1flox/-;Col2.3Cre(+)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9d41a9c-d779-4a05-b848-440287fa8b6b" - "Nf1flox/-;Cx3cr1+/gfp": - description: "Nf1+/- mouse with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a2a52f7-e0e2-4654-9157-07848c8b0bcc" - "Nf1flox/-;Krox20-Cre": - description: "peripheral nerves contain -/- Schwann cells and +/- mast cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46fb4411-d129-488c-83a5-c8e20176018e" - "Nf1flox/-;P0A-Cre-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=645fbd19-84c3-470e-bbf0-3cce94f0e6c9" - "Nf1flox/-;hGFAP-Cre": - description: "[From GFF:] Mice heterozygous for a germ-line Ex31-32 Nf1 mutation and a conditional knock-out of NF1 in astrocytes" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbf11ec4-1d12-4feb-a6fc-9faf6bc9c9db" - "Nf1flox/flox; NG2-Cre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2d103d-0d76-49aa-bf20-a17318184341" - "Nf1flox/flox;Cx3cr1+/gfp": - description: "wild-type mouse with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e71b421a-5e1d-49d6-a045-aa03aff7e7fe" - "Nf1flox/flox;Islet1-Cre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe8bd0a-f95f-46d5-b451-731c9155520b" - "Nf1flox/flox;Krox20-Cre": - description: "peripheral nerves contain -/- Schwann cells and +/+ mast cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=441ea70d-e784-4fc0-a080-50e07acf5f05" - "Nf1flox/flox;P0A-cre-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c1518d2-ea81-4cfc-bd3c-e3a6067053b1" - "Nf1flox/flox;PostnCre(+)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=215b4e43-8a99-4702-ab4b-eeeadeeb13a5" - "Nf1flox/flox;Rac1flox/+;PostnCre(+)": - description: "Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59c9a1fc-9754-40b3-8169-c2185b522a75" - "Nf1flox/floxRac1flox/flox;PostnCre(+)": - description: "Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3ae87c9-2734-4809-a08a-9212cf278437" - "Nf1flox/mut": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ff3a2b6-110b-4352-8abf-74b46c7e55ce" - "Nf1flox/mut; GFAP-Cre": - description: "NF1 conditional knock out" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4e513b5b-dde9-424d-96ff-3dd7c90f429b" - "Nf1flox/mut; NG2-Cre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=669641d6-2e7c-4679-bfe8-0d31c53c2dfc" - "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=92a431bb-182a-4f6a-92a5-4509888e2102" - Nf1pArg1947mp1: - description: "[From GFF:] Minipig model containing a recurrent nonsense mutation p.Arg1947*(R1947*) and HindIII RFLP site resulting in frame shift mutation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=209c16d7-c1fa-414f-8f08-458eaefc2259" - Nf1tm1.1Kest: - description: "[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) was introduced in exon 18 and a FRT-flanked neomycin selection cassette was inserted in intron 17. Flp-mediated recombination removed the selection cassette." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504d7dfe-acf9-476c-974d-e8665095afbb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05c510fc-2ffc-457f-ba62-679c91799800 + Nf1flox/-; GFAP-Cre; CD11b-TK: + description: Optic glioma mice with monocyte thymidine kinase expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d1c0c790-acff-486a-b794-b0429b09eeec + Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp: + description: Optic glioma mice with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e487fd33-48d3-4a02-b2e0-4d0525ee8e20 + Nf1flox/-;Col2.3Cre(+): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9d41a9c-d779-4a05-b848-440287fa8b6b + Nf1flox/-;Cx3cr1+/gfp: + description: Nf1+/- mouse with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a2a52f7-e0e2-4654-9157-07848c8b0bcc + Nf1flox/-;Krox20-Cre: + description: peripheral nerves contain -/- Schwann cells and +/- mast cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46fb4411-d129-488c-83a5-c8e20176018e + Nf1flox/-;P0A-Cre-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=645fbd19-84c3-470e-bbf0-3cce94f0e6c9 + Nf1flox/+;P0A-Cre(+): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ed9ea80-e1fe-4224-bd67-594d9d0b0c7e + Nf1flox/flox; NG2-Cre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2d103d-0d76-49aa-bf20-a17318184341 + Nf1flox/flox;Cx3cr1+/gfp: + description: wild-type mouse with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e71b421a-5e1d-49d6-a045-aa03aff7e7fe + Nf1flox/flox;Islet1-Cre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe8bd0a-f95f-46d5-b451-731c9155520b + Nf1flox/flox;Krox20-Cre: + description: peripheral nerves contain -/- Schwann cells and +/+ mast cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=441ea70d-e784-4fc0-a080-50e07acf5f05 + Nf1flox/flox;P0A-cre-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c1518d2-ea81-4cfc-bd3c-e3a6067053b1 + Nf1flox/flox;PostnCre(+): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=215b4e43-8a99-4702-ab4b-eeeadeeb13a5 + Nf1flox/flox;Rac1flox/+;PostnCre(+): + description: Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59c9a1fc-9754-40b3-8169-c2185b522a75 + Nf1flox/floxRac1flox/flox;PostnCre(+): + description: Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3ae87c9-2734-4809-a08a-9212cf278437 + Nf1flox/mut: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ff3a2b6-110b-4352-8abf-74b46c7e55ce + Nf1flox/mut; NG2-Cre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=669641d6-2e7c-4679-bfe8-0d31c53c2dfc + Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=92a431bb-182a-4f6a-92a5-4509888e2102 + Nf1Gly848Arg/Gly848Arg: + description: Homozygous for missense c.2542G>C; p.Gly848Arg mutation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4dfc91c9-31f4-4b00-a95e-4f1b26307339 + Dhh-Cre; Nf1flox/+; Ptenflox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d50930bc-c261-41a6-b517-548516044526 + Nf1 Ocl-/-: + description: Nf1-deficient osteoclasts in otherwise Nf1+/+ background + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09880210-fe90-4af9-8b1f-f886348a34eb + Nf1P1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc95a39a-5f41-4d34-9c0c-f312028aa2f3 + Nf1Prx1-/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a66bcb2-e137-4471-8cee-29dd9655b276 Nf1tm1a(KOMP)Wtsi: - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85b32836-b4c6-4f72-b0d5-a9f192fe2806" - Nf1tm1c(KOMP)Wtsi: - description: "[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A \"conditional ready\" (floxed) allele was created by flp recombinase expression in mice carrying this allele." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=361988eb-d390-4f40-b01b-acee637e2271" - Nf1tm1d(KOMP)Wtsi: - description: "[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A \"conditional ready\" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ecabd72-d36c-487e-8c0e-c05e3dd743ba" - Nf1tm2.1Kest: - description: "[From GFF:]  A point mutation, recapitulating the human missense variant c.2542G>C, in which a glycine residue at position 848 was changed to an arginine (p.Gly848Arg), was introduced in exon 21 and a FRT-flanked neomycin selection cassette was inserted in intron 20. Flp-mediated recombination removed the selection cassette." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e5c372e-dec8-4693-98a8-b07f3014257d" - "P0-GGFb3": - description: "overexpress the growth factor neuregulin-1 in Schwann cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57d32b42-8034-4ea4-a14b-78f285eed3c8" - "PlpCre;Nf1flox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5359b57-3b0a-460d-900b-dbd7cc2af7d3" - "PlpCreERT; Nf1flox/flox; eGFP": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b0b57e3-bc2d-4f0a-b42f-213be95ce457" - "Prx1-Cre+/- Nf1flox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be5c22d-862e-4739-a214-89546880a840" - "Prx1-Cre+/- Nf1flox/flox": - description: "homozygous knockout" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b0e4be7c-1b0f-4564-aa18-05b36ac77055" - "Spred1+/-": - description: "Heterozygous loss-of-function SPRED1 mutation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a8c3628-fce7-4219-825b-5551f223754d" - "Spred1-/-": - description: "SPRED1 knock-out" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4f433c0f-2c9b-41f7-9b04-ff32f524b55b" - "dNf1 Drosophila": - description: "Homozygous dNf1 null mutants" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7b76ccd-e646-4d30-8868-ba39541dd573" - "delta-ira1 delta-ira2 yeast": - description: "delta-ira1 delta-ira2 double-knockout yeast" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b2a7ee1-e462-42b9-80b8-0a64ca60b091" - "miR-155 +/-;Nf1flox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2470d9dd-b6c8-4cdb-ad2e-009071477c41" - "miR-155 +/-;Nf1flox/+;DhhCre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a79e9847-1e32-41c8-a176-adf96a8547c0" - "miR-155 -/-;Nf1flox/flox ;DhhCre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6e61b912-8006-48cb-a122-df613c8921c4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85b32836-b4c6-4f72-b0d5-a9f192fe2806 + CAMK2-CreTg/+ ; flox-NrasG12VTg/+: + description: Transgenic mouse expressing oncogenic N-ras specifically in central nerve cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06545c3d-e098-4a67-a678-6f023fda6b88 + P0-GGFb3: + description: overexpress the growth factor neuregulin-1 in Schwann cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57d32b42-8034-4ea4-a14b-78f285eed3c8 + PlpCre;Nf1flox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5359b57-3b0a-460d-900b-dbd7cc2af7d3 + PlpCreERT; Nf1flox/flox; eGFP: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b0b57e3-bc2d-4f0a-b42f-213be95ce457 + Prx1-Cre+/- Nf1flox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be5c22d-862e-4739-a214-89546880a840 + Prx1-Cre+/- Nf1flox/flox: + description: homozygous knockout + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b0e4be7c-1b0f-4564-aa18-05b36ac77055 + Spred1-/-: + description: SPRED1 knock-out + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4f433c0f-2c9b-41f7-9b04-ff32f524b55b + Spred1+/-: + description: Heterozygous loss-of-function SPRED1 mutation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a8c3628-fce7-4219-825b-5551f223754d + Nf1 Arg681*/Arg681*: + description: Created by breeding Nf1 +/Arg681* (Nf1tm1.1Kest), is embryonic lethal at day 9.5. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91e9130d-00bc-4dfe-9a5d-356e5ae3f4db + Nf1 Δ4/Δ4: + description: Created by breeding Nf1 +/Δ4, is embryonic lethal at day 9.5. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8984594-d5ff-4827-8e83-13ccbf0055e8 + Nf1 +/Δ4: + description: Mice harboring a null allele resulting from exon 4 deletion were created by breeding Nf1+/4F mice to an EIIaCre driver line (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9933922-29fb-4a4c-bc5f-604691a8bab7 + B6.FVB-Tg(EIIa-cre)C5379Lmgd/J: + description: EllaCre driver line. + meaning: rrid:IMSR_JAX:003724 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5511a019-88aa-43c8-86c3-ad1677c8a3d0 AnimalModelManual: permissible_values: C57BL/6J: @@ -6193,2266 +6207,2302 @@ enums: - Teratoma, Not Otherwise Specified description: A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach meaning: NCIT:C3403 + CellLineCategoryEnum: + description: Category of cell line based on origin and characteristics + permissible_values: + Cancer cell line: + description: Cell line derived from cancer/tumor tissue + Induced pluripotent stem cell: + description: Pluripotent stem cells generated from somatic cells through reprogramming + Transformed cell line: + description: Cell line transformed by viral or chemical agents + Telomerase immortalized cell line: + description: Cell line immortalized through telomerase expression + Embryonic stem cell: + description: Pluripotent stem cell derived from embryonic tissue + Finite cell line: + description: Cell line with limited passage potential + Hybrid cell line: + description: Cell line created by fusion of two different cell types + Hybridoma: + description: Hybrid cell line formed by fusion of antibody-producing cells with myeloma cells + Spontaneously immortalized cell line: + description: Cell line that spontaneously acquired immortalization + Undefined cell line type: + description: Cell line with unspecified or unknown category + CellLineGeneticDisorderEnum: + description: Genetic disorder associated with the cell line + permissible_values: + Neurofibromatosis type 1: + description: Cell line derived from or associated with NF1 + Neurofibromatosis type 2: + description: Cell line derived from or associated with NF2 + Schwannomatosis: + description: Cell line derived from or associated with schwannomatosis + Noonan Syndrome: + description: Cell line derived from or associated with Noonan Syndrome + No known genetic disorder: + description: Cell line with no known associated genetic disorder CellLineModel: permissible_values: - "10/9CRC1": - meaning: rrid:CVCL_8478 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25c617df-ff54-4ba5-b293-d9fcc9be39ce" - 10CM: - description: "Mutation of NF1, p.Arg440Ter (c.1318C>T), Unspecified zygosity (PubMed=26744134). Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26744134)." - meaning: rrid:CVCL_VJ83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423cc0f3-8a43-4e10-a9a4-d529aa78f022" - '1507.2': - meaning: rrid:CVCL_1Y71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4304050f-f24a-45b9-9025-8e3e88d0b377" - "2-004": - description: "Patient-derived cell line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b44907f-47e9-470f-918e-03e55cc9eff9" + HEK293 NF1 -/- with R1306X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1306X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02dacc42-ea46-48fb-a4df-7a875d801086 + SZ-NF4: + description: Human embryonic stem cell line derived from an embryo with an NF1 mutation. + meaning: rrid:CVCL_YL59 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09c988ab-765a-44ca-b2d7-1957b729208e + HBE135-E6E7: + description: '[From ATCC:] The HBE135-E6E7 cell line was derived from normal bronchial epithelium taken from a man undergoing lobectomy for squamous cell carcinoma. Cells from the primary explant in their first passage were infected with the recombinant retrovirus LXSN16E6E7 containing the human papilloma virus (HPV) E6E7 gene.' + meaning: rrid:CVCL_3695 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a1a3741-0337-4067-95ab-fb0dc9562d66 + 90-8: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_1B47 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f404e70-2acf-4877-bcd5-6da81d9fa41e + WT ES: + description: '[From GFF:] WT ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1097f821-56c3-4e51-bcd3-f84aef506e3a + 'HEK293 NF1 -/- Exon 47 insT #14': + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 47 insT #14' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=130fd347-28e1-46c2-a72d-d243e99322b7 + hTERT SC ipn97.4: + description: Healthy Schwann cells. + meaning: rrid:CVCL_UI66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13ae2445-21e3-4b75-ae70-317a3d5ee40c + HEK293 NF1 -/- with R1947X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1947X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14353c91-2be9-4617-b337-c29080961826 + Nf1-/- skin-derived precursor cells: + description: '[From GFF:] Nf1-/- skin-derived precursor cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=15c3bd82-9791-4a53-b6f7-4d23b882a285 + KCL025: + description: Human embryonic stem cell line derived from an embryo with an NF1 mutation. + meaning: rrid:CVCL_A258 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=18ba4c2e-e8d5-4032-a6ab-d0fca3f0f984 + NF1: + description: Cell line from an NF1 patient; unclear if derived from tumor or non-tumor tissue. + meaning: rrid:CVCL_JG80 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a8a362e-e3be-4bc3-be7e-d0a0865b9c31 + Dhh-Cre; NF1Arg681*/flox Schwann Cells: + description: '[From GFF:] Dhh-Cre; NF1Arg681*/flox Schwann Cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae5651a-818f-4732-8045-17bea2555056 + NCC-MPNST3-X2-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU15 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b604846-d41c-4969-a79a-9660c04e585c + 3PNF_SiPSsv_MM_11: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cc872fc-6a95-4722-a598-bf60bb124b82 + ST88-14: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_8916 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=202c110b-a5f1-49ab-acdc-e6e33a1c29bb + 'Schwann cell NF1 -/- (iPN97.4 #24)': + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- (iPN97.4 #24)' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=234515dd-7c28-4172-83c7-59dddfa22acb + HeLa SilenciX NF1: + description: HeLa cervical cancer cells with stable (EBV-based siRNA) knockdown of the NF1 gene. + meaning: rrid:CVCL_KT82 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2549e536-b033-43e4-acf6-501499b6e498 + hTERT NF1 ipnNF95.11c: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI69 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c4c8b02-f12e-4a17-a408-38ae88dd841d + ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3239573e-4ae1-4e01-8098-00dce6ac0a84 + HEK293 NF1 -/- with R681X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R681X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=32f73d96-fd2a-4966-a150-ba5fa47d150c + SZ-NF1: + description: Human embryonic stem cell line derived from an embryo with an NF1 mutation. + meaning: rrid:CVCL_YL57 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=33cdb482-618e-4489-87d9-3139cc7c6a49 + Schwann cell NF1 -/- with R816X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R816X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a3e5460-3d5b-45f9-995d-25bd49c06f34 + hTERT ipn02.3 2λ: + description: Derived from peripheral sciatic nerve from a donor without neurofibromatosis. No detectable NF1 mutation. + meaning: rrid:CVCL_UI64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a507bfd-7d2b-4238-b79a-83fe985c2cea + hTERT ipn02.8: + description: Derived from peripheral nerve from a donor without neurofibromatosis. No detectable NF1 mutation. + meaning: rrid:CVCL_UI65 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a8f5be4-aa22-48f2-9a76-9412010ecd45 + Schwann cell NF1 -/- with WT tagged mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with WT tagged mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3beebac1-95b0-4834-9008-19f7d268fc5b + hTERT NF1 ipn06.2 A: + description: Derived from a pleural plexiform neurofibroma. + meaning: rrid:CVCL_UI74 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dedf9d2-614c-4cf9-8d18-aff8aa2dc0eb + HEK293 NF1 -/- with R461X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R461X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f29aa26-1d05-453a-a6ac-d4e37d609dba + Nf1-/- HEK 293: + description: '[From GFF:] Nf1-/- HEK 293' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=44f9c496-ddd8-4e4b-bddb-6b93f7e04fc2 + icNF98.4c: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4c). + meaning: rrid:CVCL_B9V7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46da7a41-c654-426e-bfb7-361caf4d3c4c + Nf1Arg681*/Arg681* MEFs: + description: '[From GFF:] Nf1Arg681*/Arg681* MEFs' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47f50ef0-8d59-430d-9d05-7df1a4f41c3b + GM23338: + description: '[From GFF:] iPSC NF1 WT, PGP1 cells' + meaning: rrid:CVCL_F182 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c4e4b03-5975-4708-a25c-f6c45cbe3abf + iPSC NF1 WT: + description: '[From GFF:] iPSC NF1 WT BJFF.6 bkgd' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4cf14492-2735-4e31-ab6a-75554b9ad298 + sNF94.3: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K164 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504647eb-6b60-492a-bb51-3ab025830f51 + hTERT NF1 ipNF05.5: + description: Derived from a plexiform neurofibroma growing on a hand. + meaning: rrid:CVCL_UI71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5502caf5-4cf1-418f-bf50-164cfa316b0f 28cNF: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (i28NF)." + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (i28NF). meaning: rrid:CVCL_B9V9 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a466cdc-5eaa-45a5-87b1-ba9cac6d7d21" - 2XSB: - meaning: rrid:CVCL_A7NI - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f4e4596-0c7d-4d41-b9ff-73ecebd30263" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a466cdc-5eaa-45a5-87b1-ba9cac6d7d21 + YST-1: + description: Schwannoma cell line, potentially mischaracterized in some cases as a sporadic MPNST cell line. + meaning: rrid:CVCL_5192 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=617cb183-3377-4473-8ad8-2f6472bce1fa + T265: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_S805 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6419dd0d-1937-4ecf-bf01-876632ae0f54 + Dh5 alpha: + description: '[From GFF:] Dh5 alpha' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=68977077-e0a3-40df-92ab-d62285edd23c + Nf1Arg681*/+ ES: + description: '[From GFF:] Nf1Arg681*/+ ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ff97eee-5c1a-4439-9df6-d1715cbdd189 + Nf1Arg681*/Arg681* ES: + description: '[From GFF:] Nf1Arg681*/Arg681* ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=70c1e3f6-751f-49e4-aa47-e3bea4aeac43 + icNF04.9a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF04.9a). + meaning: rrid:CVCL_B9VC + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=75d4b88a-a906-4f08-a9f8-66490328b9f1 + Nf1-/- Epithelial lung cells: + description: '[From GFF:] Nf1-/- Epithelial lung cells, derived from HBE135-E6E7 epithelial lung cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=779714c8-f522-4355-a502-d5d2e6e09afa + HEK293: + description: '[From ATCC:] This is a hypotriploid human cell line.' + meaning: rrid:CVCL_0045 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7b6dcc42-3c32-4008-8b2c-309aa01b17be + 'HEK293 NF1 -/- Exon 52 R2550X #5': + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 52 R2550X #5' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d565aea-0917-428b-9101-d2a19f3fbcf1 3PNF_FiPSsv_PM_2: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank. meaning: rrid:CVCL_UN11 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7deb7765-38aa-4d8a-a3cb-bd4aefeb3a86" - 3PNF_SiPSsv_MM_11: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." - meaning: rrid:CVCL_UN12 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cc872fc-6a95-4722-a598-bf60bb124b82" - "4/30PRR": - meaning: rrid:CVCL_8480 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0aed5bf6-d5e2-4a6d-ac3b-a51b5e8bbb8b" - 5PNF_TDiPSsv_MM_4: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." - meaning: rrid:CVCL_UN13 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db6b3d0d-ee80-49ab-bb51-5672448e580b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7deb7765-38aa-4d8a-a3cb-bd4aefeb3a86 + icNF00.10a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF00.10a). + meaning: rrid:CVCL_B9V0 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ef2fd6f-9ba6-4e30-94fc-d4ffd61de6e6 + NCC-MPNST3-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU14 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7fe31236-bc93-449b-b559-9394999be926 + NCC-MPNST5-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU17 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=827f08a1-3d0f-4fd8-98e4-fb5c40a9c742 + hTERT NF1 ipNF05.5 (Mixed clones): + description: Derived from a plexiform neurofibroma growing on a hand. + meaning: rrid:CVCL_UI72 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844b598c-0171-4972-91c3-27aa21b45d52 + cNF98.4d: + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4d). + meaning: rrid:CVCL_B9V6 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=882101e0-1207-4323-a354-6d5a642e6ca3 + BJFF.6: + description: iPSCs created with foreskin fibroblasts. + meaning: rrid:CVCL_VU02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8a213a9d-392b-4746-8f59-c12f753d9217 + hTERT NF1 ipnNF09.4: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI73 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e0602ff-e3e6-438e-9fb7-c7abc1dd4304 + i28cNF: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (28NF). + meaning: rrid:CVCL_B9VA + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e9ec3f3-5622-4f8f-a02c-34d8777c82b6 5PNF_TDiPSsv_PM_6: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank. meaning: rrid:CVCL_UN14 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ebe9be8-88df-4598-bd25-510de550ca5e" - 6PNF_SiPSrv_PM_2: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." - meaning: rrid:CVCL_UN15 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4deb9a8-7929-44f2-974d-375771b8c681" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ebe9be8-88df-4598-bd25-510de550ca5e + NCC-MPNST2-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU13 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f646e44-5263-4f80-bb94-b297a875c52a + hTERT NF1 ipNF04.4: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI78 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fdc5f7a-ef8c-4193-a5c0-04577c3b134d + NF1-R68X Embryonic cells: + description: '[From GFF:] NF1-R68X Embryonic cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90748442-be62-44f1-899e-804cd5600823 7PNF_SiPSrv_PM_12: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank. meaning: rrid:CVCL_UN16 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95997768-950e-4c8d-93bb-e6ed370e503f" - 862L: - meaning: rrid:CVCL_8477 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6faf7e00-d770-4527-9384-539f6db31977" - "9/3L": - meaning: rrid:CVCL_8479 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c98ce5c-5cf1-4829-943d-5142073583d8" - "90-8": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_1B47 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f404e70-2acf-4877-bcd5-6da81d9fa41e" - A68: - description: "From a surgically excised pNF specimen of a 51-year-old female with NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=328fd785-453d-4a09-be93-b7da67d9d33e" - "AMC-106": - meaning: rrid:CVCL_9477 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf77b1e3-93be-4b4e-bc34-85d8b9d06a81" - "Abcam A-549 NF1 KO": - description: "Mutation of KRAS, p.Gly12Ser (c.34G>A), Homozygous (from parent cell line)." - meaning: rrid:CVCL_B9NJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d605ae2e-969a-4956-bac5-5e36654d7b41" - "Abcam HCT 116 NF1 KO": - description: "Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (from parent cell line)." - meaning: rrid:CVCL_B8LD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5ec9375-0564-414a-94ad-86d5083b440f" - "Abcam HeLa NF1 KO": - description: "Nf1 knockout cell" - meaning: rrid:CVCL_B1YJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b26e0c8b-689f-4018-bf27-e2d3a522e039" - "Abcam MCF-7 NF1 KO": - description: "Nf1 knockout cell" - meaning: rrid:CVCL_B8ZE - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24719e11-8ac2-452c-9424-20d75fc26d82" - "Abcam U-87MG SNCA KO": - description: "Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)." - meaning: rrid:CVCL_C0BJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5f5d4a-95f7-4e5c-9db1-d13fbc9748a7" - "AsPC-1": - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=15367885, PubMed=21607521, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0152 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bbfd278-a1aa-4279-b648-94efe9e1f242" - BJFF.6: - description: "iPSCs created with foreskin fibroblasts." - meaning: rrid:CVCL_VU02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8a213a9d-392b-4746-8f59-c12f753d9217" - "BTSC 232": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4d9d286-d169-41d0-8dc8-45bc92984aaf" - "BTSC 233": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b664f320-dd73-4aae-82e7-91c42b48744a" - "BTSC 3021": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f98c4bb5-b168-431a-8642-f769bed673a3" - "BTSC 3047": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=852b8fa5-892d-4353-9d6b-4673396ca999" - "BTSC 349": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ea69fa4e-4393-4ffe-a5a8-f4df59789813" - "BTSC 380": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98790fc2-9cdf-442c-94d2-e6775cfb8ad3" - "BayGenomics ES cell line XF344": - description: "Nf1 knockout cell" - meaning: rrid:CVCL_PR85 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=60633d59-0230-47c3-9d40-08b0ae194b6d" - "CFPAC-1": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=11169959, PubMed=11787853, PubMed=15367885, Cosmic-CLP)." - meaning: rrid:CVCL_1119 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6f287de-eadb-4020-be7a-5b761172fec6" - "CML-6M": - description: "Pigmented. Mutation of NF1, p.Pro1599fs (c.4795delCinsTT), Heterozygous (PubMed=31175136)." - meaning: rrid:CVCL_0D24 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=acd954de-1f36-41ad-8ce0-ac738aa840ba" - "COLO 668": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1128 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a57bc0e-51ee-4a44-a872-2ed8ab56f4c6" - "COR-L23": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1139 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6928d53-c913-4078-8354-4a5de3d5c824" - "CPTC-NF1-1": - meaning: rrid:CVCL_C2NU - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65d07476-2469-4679-85b2-e2ca67f3b01b" - "CPTC-NF1-2": - meaning: rrid:CVCL_C2NV - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f410431d-7571-4302-8870-eb115b71d0ce" - "CPTC-NF1-3": - meaning: rrid:CVCL_C2NW - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42257ac4-1950-4541-9bee-b9a965e2fa86" - "CTV-1": - description: "Mutation of NF1, p.Gly1532Arg (c.4594G>A), Heterozygous (PubMed=22675565, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1150 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37cbf7b9-f74c-4407-8541-86c17e394c5d" - "Calu-1": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=12794755, DepMap)." - meaning: rrid:CVCL_0608 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=055e78dc-b3d2-416b-a7f1-ac4de9d9ec2b" - "Capan-1": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=8026879, PubMed=8426738, PubMed=15367885, PubMed=21750719, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0237 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efe31e45-2075-4b41-a06f-a1d5935622fa" - "Capan-2": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=7961102, PubMed=8026879, PubMed=8426738, PubMed=11169959, PubMed=15367885, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0026 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a32eaaa-e7cf-45a2-ae52-528a09eea541" - "D-566MG": - description: "Mutation of NF1, p.Ile941Serfs*13 (c.2820delC), Heterozygous (Cosmic-CLP)." - meaning: rrid:CVCL_1166 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc7c0fee-8a89-49a2-b58c-eff50448006d" - "DAN-G": - description: "2 alleles of G12V mutation in KRAS gene. Established from a xenograft produced by implantation of cells from the tumor of a patient with cancer of the pancreas in a nude mouse (CLS). Mutation of KRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (CLS, Cosmic-CLP)." - meaning: rrid:CVCL_0243 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=99359d65-6e01-410d-be59-217aa0bfb9c9" - DD2345: - description: "An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line" - meaning: rrid:CVCL_9J79 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2e792f78-55b0-4091-9f86-6b78abd920bb" - "Dh5 alpha": - description: "[From GFF:] Dh5 alpha" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=68977077-e0a3-40df-92ab-d62285edd23c" - "Dhh-Cre; NF1Arg681*/flox Schwann Cells": - description: "[From GFF:] Dhh-Cre; NF1Arg681*/flox Schwann Cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae5651a-818f-4732-8045-17bea2555056" - "ELK-TAD Luciferase Reporter HEK293 Stable": - description: "[From GFF:] ELK-TAD Luciferase Reporter HEK293 Stable" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c88fcbc9-24c1-4f2b-8d13-02f5037dcf1c" - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3239573e-4ae1-4e01-8098-00dce6ac0a84" - "FMS-1": - meaning: rrid:CVCL_IS33 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b14a6ae1-829c-4ae3-9149-9fcf6cc6c57d" - "FTC-133": - description: "Has a near-homozygous genome (NHG). Mutation of NF1, p.Cys167Ter (c.501T>A), Homozygous (PubMed=30737244)." - meaning: rrid:CVCL_1219 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a630172-cf98-41c1-ae06-c436900fb513" - "FU-SFT8710": - meaning: rrid:CVCL_ZE77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b96c1fa0-5284-424a-b29e-338db3c8b292" - "GI-ME-N": - description: "Gene deletion, NF1, Heterozygous (PubMed=20655465). Mutation of NF1, Microdeletion, Heterozygous (PubMed=20655465)." - meaning: rrid:CVCL_1232 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe5b49ff-6d77-4de3-adc3-0fc97fd076e4" - "GI-ME-NrCDDP500": - description: "Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line)." - meaning: rrid:CVCL_RS22 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=73b8caeb-cc91-4d81-b076-25d611949807" - "GI-ME-NrDOX5": - description: "Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line)." - meaning: rrid:CVCL_RS07 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a03250ca-0914-4318-b5c6-5b5a86ca1965" - "GI-ME-NrVCR14": - description: "Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line)." - meaning: rrid:CVCL_RR32 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25fa8030-970e-48ec-8e22-55e23a747164" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95997768-950e-4c8d-93bb-e6ed370e503f + HEK293 NF1 -/- with WT tagged mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT tagged mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96d339f9-9d19-40c3-8f81-3590f7c00205 + hTERT NF1 sipnNF95.12B: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI75 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98beda5b-9b28-4119-829a-2a0219d77af7 + STS-26T: + description: Sporadic MPNST tumor cell line from a non-NF1 patient. + meaning: rrid:CVCL_8917 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9a7997c9-9399-47ed-b44b-5b717be89ba3 + 'HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice': + description: '[From GFF:] HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b4b8eca-f981-440d-b478-0a5483353368 + iPSC NF1 +/- BJFF.6 bkgd: + description: '[From GFF:] iPSC NF1 +/- BJFF.6 bkgd' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0c91627-fad6-4d60-bf74-67623374eff8 + GM11601: + description: Leukemia cell line derived from B-lymphocytes from an NF1 patient. + meaning: rrid:CVCL_AA01 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2f62c57-a1b8-4867-9c91-04406f261cfa + icNF97.2a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2a). + meaning: rrid:CVCL_B9V3 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a731535e-f7a6-4c6e-b0db-7f0d0979e69f + hTERT NF1 ipNF00.6: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI76 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8f48ce7-438c-4564-a70b-020abc96d5fe + HEK293 NF1 -/- with R2550X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R2550X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aa32fc67-9cc3-4d31-bcbd-f7044f9fd484 + hTERT NF1 ipNF95.11b C/T: + description: Derived from a plexiform neurofibroma growing on a brachial plexus. + meaning: rrid:CVCL_UI68 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ab60aae5-7860-4d1d-bb02-208e6631c78b + cNF00.10a: + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF00.10a). + meaning: rrid:CVCL_B9UZ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad2e271b-55ac-44ae-b39d-f1a6d76e1dc3 + iPSC Y489C; Exon 13 cryptic splice: + description: '[From GFF:] iPSC Y489C; Exon 13 cryptic splice, PGP1 cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad73cdb2-8add-48ff-b9f2-35a38132db84 + 'HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice': + description: '[From GFF:] HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae765b00-9189-4a72-8ae7-cddc41e24055 + S462: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_1Y70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2fb9f7e-ea11-404f-8c0c-c9dc36367f2d + hTERT NF1 ipNF95.6: + description: Derived from a plexiform neurofibroma growing on cranial nerve XII. + meaning: rrid:CVCL_UI70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b44361f2-9021-4920-901a-b1a1f9143f97 + cNF97.2b: + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2b). + meaning: rrid:CVCL_B9V2 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4987f0a-67ec-4f13-96f1-9443aac6e5ac + sNF02.2: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K280 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b72d99fd-ee1e-42ec-92b6-9f89e375cce1 + ScienCell Schwann cells: + description: '[From ScienCell:] HSC from ScienCell Research Laboratories are isolated from human spinal nerve. (editorial note: these cells likely come from multiple donors)' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b751b5d4-56e6-42a2-a2dc-289f90c6dd82 + icNF98.4d: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4d) + meaning: rrid:CVCL_B9V8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd74fd9f-6357-40d5-8569-96883628fb1a + hTERT NF1 ipNF95.11b C: + description: Derived from a plexiform neurofibroma growing on a brachial plexus. + meaning: rrid:CVCL_UI67 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be2333d6-6716-4d13-947d-41f4198497a4 + S520: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_AX35 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0a60dec-8ead-43c5-abc2-b06b89dd20cd + cNF04.9a: + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF04.9a). + meaning: rrid:CVCL_B9VB + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5b9e065-6855-4a11-bceb-681d8e82ae5e + ELK-TAD Luciferase Reporter HEK293 Stable: + description: '[From GFF:] ELK-TAD Luciferase Reporter HEK293 Stable' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c88fcbc9-24c1-4f2b-8d13-02f5037dcf1c + sNF96.2: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K281 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c9a87975-378b-4930-8fda-e5896c42c86c + SZ-NF2: + description: Human embryonic stem cell line derived from an embryo with an NF1 mutation. + meaning: rrid:CVCL_YL58 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc2045df-5ebf-4491-b5b1-88d65e59b228 + Lis42_NF1_1N: + description: Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1. + meaning: rrid:CVCL_Y368 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd38ffda-2db1-47f0-af6f-8de572e06037 + Lis47_NF1_2N: + description: Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1. + meaning: rrid:CVCL_Y373 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0ca95f1-a3d9-4641-b47d-84346d9ec04a + cNF97.2a: + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2a). + meaning: rrid:CVCL_B9V1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d390b3f3-fea7-46d2-9bb7-dc72d59b2ccc + S462.TY: + description: MPNST tumor cell line from an NF1 patient, created by passaging S462 cell line in mice as xenografts. + meaning: rrid:CVCL_JK02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6a101aa-9ca8-4191-9b43-eddf327ea48b + 5PNF_TDiPSsv_MM_4: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN13 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db6b3d0d-ee80-49ab-bb51-5672448e580b + cNF98.4c: + description: A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4c). + meaning: rrid:CVCL_B9V5 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df513bb8-697a-4cac-ae6c-5aca6113ac24 + 6PNF_SiPSrv_PM_2: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN15 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4deb9a8-7929-44f2-974d-375771b8c681 + KCL024: + description: Human embryonic stem cell line derived from an embryo with an NF1 mutation. + meaning: rrid:CVCL_A257 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5fdcfb8-24e7-46fa-9f48-bcbae8a90b7a + icNF97.2b: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2b). + meaning: rrid:CVCL_B9V4 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb920757-ad44-4705-815e-31b5bd6105f5 + HEK293 NF1 -/- with R816X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R816X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f047cff6-98c8-4562-b589-94b864ae35a1 + NCC-MPNST4-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU16 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f17b839e-acd9-4dbc-a5bb-7d72ed0d0bd8 + hTERT NF1 ipNF03.3: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f21cb7db-ee85-48a7-8f41-e4603238bede + HEK293 NF1 -/- with WT mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2d00598-9db3-4549-a473-16b1db349614 + GM11602: + description: Leukemia cell line derived from B-lymphocytes from an NF1 patient. + meaning: rrid:CVCL_AA02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f354ec1a-0305-4e6c-897a-10e4fba10a28 + HEK293 NF1 -/- clone 2: + description: '[From GFF:] HEK293 NF1 -/- clone 2' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f59f3308-a440-497d-8eee-8d7756a9ae2b + Schwann cell NF1 -/- with R681X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R681X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=faf29a50-3168-4ccd-a484-f2a78a026af3 + HEK293 NF1 -/- with R192X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R192X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb67363f-d309-4c7c-ba1e-f295ba411018 + NCC-MPNST1-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc3ae45e-9a5b-4fa5-8430-f53479f07f5a + KOMP ES cell line Nf1: + description: JM8.F6 derived from C57BL/6N + meaning: rrid:MMRRC_059313-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d596eb56-33b0-4dcc-b7e4-0922a93c4134 + KOMP ES cell line Nf1: + description: JM8.F6 derived from C57BL/6N + meaning: rrid:MMRRC_059314-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e0a4cc28-022b-48ed-acf5-28ee38eb20bd + SIGTR ES cell line AA0320: + description: High throughput gene trapping was performed by inserting a gene trap vector containing a splice-acceptor sequence upstream of a reporter gene, β-geo (a fusion of β-galactosidase and neomycin phosphotransferase II), into an intronic or coding region of genomic DNA. The resulting insertional mutation creates a fusion transcript containing sequences from exons upstream of the insertion joined to the β-geo marker, allowing cell lines where the vector has successfully interrupted a gene to be identified. + meaning: rrid:MMRRC_025689-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8a75443-a92f-45f7-9290-0669405e2e9c GM00622: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_5M64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1edebf4d-8ea4-4071-90bf-7e934c7ab029" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1edebf4d-8ea4-4071-90bf-7e934c7ab029 GM01633: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_9Z54 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa663228-7ffe-4604-9cda-95b29b8d7386" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa663228-7ffe-4604-9cda-95b29b8d7386 GM01634: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z57 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9722c74b-e82e-4ac7-b684-4bab1a409a78" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9722c74b-e82e-4ac7-b684-4bab1a409a78 GM01639: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_5M68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2677690-2137-408e-b250-784a0cd235f4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2677690-2137-408e-b250-784a0cd235f4 GM01641: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_5M69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9db66052-f458-4400-ae1b-3f5c075dbd25" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9db66052-f458-4400-ae1b-3f5c075dbd25 GM01858: - description: "Fibroblast from Neurofibroma from an NF1 patient" + description: Fibroblast from Neurofibroma from an NF1 patient meaning: rrid:CVCL_9Z58 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4e97f99-a857-4f2d-80f1-62de8a12d037" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4e97f99-a857-4f2d-80f1-62de8a12d037 GM01859: - description: "Fibroblast from Neurofibroma from an NF1 patient" + description: Fibroblast from Neurofibroma from an NF1 patient meaning: rrid:CVCL_9Z59 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3899a07c-6fb8-4fc2-997f-c2301d6082f7" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3899a07c-6fb8-4fc2-997f-c2301d6082f7 GM01861: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z60 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46cc2e4e-d9bf-4474-b4de-448e25fb0c66" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46cc2e4e-d9bf-4474-b4de-448e25fb0c66 GM03420: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z61 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ebbfa6b-049f-4e85-af96-be49c3b5b31a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ebbfa6b-049f-4e85-af96-be49c3b5b31a GM03421: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z62 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5570368b-f20e-47ed-9656-0b9d49c53c9f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5570368b-f20e-47ed-9656-0b9d49c53c9f GM09534: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z63 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4106cadd-2071-437e-8c43-6f5751332128" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4106cadd-2071-437e-8c43-6f5751332128 GM09535: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bdf2270-d002-41bf-b75d-2a1d890f9967" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bdf2270-d002-41bf-b75d-2a1d890f9967 GM09536: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z65 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=afcff3ca-6421-4c66-bd87-94ad21493b1d" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=afcff3ca-6421-4c66-bd87-94ad21493b1d GM09539: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f77c8f5-a9a2-4d1a-a34a-79e912718c91" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f77c8f5-a9a2-4d1a-a34a-79e912718c91 GM09616: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z67 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c569a3f9-9c0c-48fe-bbb5-7ae5cb6c384a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c569a3f9-9c0c-48fe-bbb5-7ae5cb6c384a GM09617: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f34019e4-be8b-4f75-9f68-a79032c8705b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f34019e4-be8b-4f75-9f68-a79032c8705b GM09618: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_N114 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a9d486c-1cd0-4cab-b3d7-cbe17058d457" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a9d486c-1cd0-4cab-b3d7-cbe17058d457 GM09619: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bdd8125b-cf6d-45f3-8cea-20af6e21a1da" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bdd8125b-cf6d-45f3-8cea-20af6e21a1da GM09620: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=559404ce-6df0-4109-bdeb-6521d8928f1c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=559404ce-6df0-4109-bdeb-6521d8928f1c GM09621: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=026b1ceb-5f1c-4497-825c-ee3cc5d9d2ed" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=026b1ceb-5f1c-4497-825c-ee3cc5d9d2ed GM09622: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4cf20b8-9e30-4798-8281-25b83346458d" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4cf20b8-9e30-4798-8281-25b83346458d GM09625: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0843b842-e9d2-4b23-9a53-aebf01ae31e3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0843b842-e9d2-4b23-9a53-aebf01ae31e3 GM09626: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_N115 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59bac805-44b6-4397-8195-6005fcedcd95" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59bac805-44b6-4397-8195-6005fcedcd95 GM09627: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96456d2b-062d-42ab-a1ce-ff3df6f7ab5b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96456d2b-062d-42ab-a1ce-ff3df6f7ab5b GM09628: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z75 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b636771-68eb-4a86-801e-546bcb4f9b25" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b636771-68eb-4a86-801e-546bcb4f9b25 GM09629: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z76 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86145b27-da2e-4b32-9ddc-e247374fe10e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86145b27-da2e-4b32-9ddc-e247374fe10e GM09630: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be65ffe-18cb-46c4-b910-6e5a3cc5612a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be65ffe-18cb-46c4-b910-6e5a3cc5612a GM09631: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z78 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22ca8958-b953-461d-9301-016f57cd08a5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22ca8958-b953-461d-9301-016f57cd08a5 GM09632: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z79 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a28aea84-6495-4863-80cc-08066079deef" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a28aea84-6495-4863-80cc-08066079deef GM09633: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cba1c774-499d-4d01-b3d2-a62f670b03ce" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cba1c774-499d-4d01-b3d2-a62f670b03ce GM09634: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z81 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=327fcda4-f2ef-4cb5-9245-d3256960f17f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=327fcda4-f2ef-4cb5-9245-d3256960f17f GM09635: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9d1561b3-b430-4a9b-984d-1c77a02f1a23" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9d1561b3-b430-4a9b-984d-1c77a02f1a23 GM09636: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b213001-31a3-4c59-bf32-4e5407c01e82" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b213001-31a3-4c59-bf32-4e5407c01e82 GM09637: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z84 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fd4f461-6137-4922-81b1-e9f30d993df1" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fd4f461-6137-4922-81b1-e9f30d993df1 GM09638: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z85 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f00ae7c4-4eea-49e4-92d1-43382dfd31bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f00ae7c4-4eea-49e4-92d1-43382dfd31bb GM09639: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z86 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd411ce0-865d-47d7-a5c4-84084f5aadb5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd411ce0-865d-47d7-a5c4-84084f5aadb5 GM09640: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z87 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6a894263-7e2b-46f5-81b1-9aa351590843" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6a894263-7e2b-46f5-81b1-9aa351590843 GM09641: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z88 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc42f6e8-494c-49ff-880f-be2352f3a87e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc42f6e8-494c-49ff-880f-be2352f3a87e GM09642: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z89 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6d3fc47-cd5d-4b7e-a5b7-7c10cecb2490" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6d3fc47-cd5d-4b7e-a5b7-7c10cecb2490 GM09649: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z90 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4996ae57-c5df-4832-8990-cea9133004bc" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4996ae57-c5df-4832-8990-cea9133004bc GM09650: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z91 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b16247aa-fd06-4103-9f5e-50e0e7d06805" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b16247aa-fd06-4103-9f5e-50e0e7d06805 GM09651: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z92 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=432fefde-722b-44f0-8f11-bbc97920b5f6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=432fefde-722b-44f0-8f11-bbc97920b5f6 GM09652: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z93 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08309e7c-d0a5-457e-91bc-9c5113347ee2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08309e7c-d0a5-457e-91bc-9c5113347ee2 GM09688: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z94 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09799642-3547-4033-a094-5ba1dd08da60" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09799642-3547-4033-a094-5ba1dd08da60 GM09689: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z95 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=220c8dae-1759-4834-b952-c9b68469137a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=220c8dae-1759-4834-b952-c9b68469137a GM09690: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z96 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41307a11-4252-4563-bb7d-afe570cf1620" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41307a11-4252-4563-bb7d-afe570cf1620 GM09691: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z97 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7df4a356-0194-47d4-9a78-291b8083ed18" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7df4a356-0194-47d4-9a78-291b8083ed18 GM09692: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z98 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c83b346e-57de-41b3-9a28-7e60a2f78483" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c83b346e-57de-41b3-9a28-7e60a2f78483 GM09693: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_9Z99 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1dbbb94-a4e6-4829-a3db-455480b0a535" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1dbbb94-a4e6-4829-a3db-455480b0a535 GM09694: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_6F53 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6b2e6bfa-e869-4970-a71c-10abd3224ea9" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6b2e6bfa-e869-4970-a71c-10abd3224ea9 GM09886: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9T23 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f597b96-5566-45f6-81c6-592c82cb3465" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f597b96-5566-45f6-81c6-592c82cb3465 GM09887: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9X49 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed96e95-c815-4151-ade9-40510601255f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed96e95-c815-4151-ade9-40510601255f GM09944: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_AA00 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0abcee2-581c-4c1a-9ef8-93b57dd0f96d" - GM10501: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R95 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb" - GM10502: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R96 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965" - GM10657: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R97 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7" - GM10659: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R98 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3" - GM11601: - description: "Leukemia cell line derived from B-lymphocytes from an NF1 patient." - meaning: rrid:CVCL_AA01 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2f62c57-a1b8-4867-9c91-04406f261cfa" - GM11602: - description: "Leukemia cell line derived from B-lymphocytes from an NF1 patient." - meaning: rrid:CVCL_AA02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f354ec1a-0305-4e6c-897a-10e4fba10a28" - GM12517: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1S66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0abcee2-581c-4c1a-9ef8-93b57dd0f96d GM21674: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_HL11 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2e3f513-8780-4f7e-985a-4dd4eab7de95" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2e3f513-8780-4f7e-985a-4dd4eab7de95 GM21675: - description: "Fibroblast derived from skin from an NF1 patient" + description: Fibroblast derived from skin from an NF1 patient meaning: rrid:CVCL_HL12 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf150ecf-4971-4500-ae94-5d25e4895d63" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf150ecf-4971-4500-ae94-5d25e4895d63 GM21843: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_BA07 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4280272c-022d-45bd-9c0f-20d96b69aba8" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4280272c-022d-45bd-9c0f-20d96b69aba8 GM21844: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_BA08 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7c5369fa-2ea8-45a1-93be-d6e22e1ac695" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7c5369fa-2ea8-45a1-93be-d6e22e1ac695 GM21845: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_BA09 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3281d1ba-5d0d-4dca-b583-9c610814fb76" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3281d1ba-5d0d-4dca-b583-9c610814fb76 GM21865: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_BA10 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=38dcffa4-463a-482b-8d6c-5d787ac3a1c4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=38dcffa4-463a-482b-8d6c-5d787ac3a1c4 GM22279: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_BA11 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ba4aabde-a800-4cca-b4de-1f4f4c8c06cc" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ba4aabde-a800-4cca-b4de-1f4f4c8c06cc GM22606: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_BU80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=809601e0-75ef-460c-9e95-9c454e06c474" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=809601e0-75ef-460c-9e95-9c454e06c474 GM22607: - description: "Fibroblast derived from skin from an NF1 patient" + description: Fibroblast derived from skin from an NF1 patient meaning: rrid:CVCL_BU81 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc4c4f3b-34c3-447f-9422-0262d7b43ae5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc4c4f3b-34c3-447f-9422-0262d7b43ae5 GM22608: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient meaning: rrid:CVCL_BU82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce964197-a694-41fb-8f25-66cd84c86e50" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce964197-a694-41fb-8f25-66cd84c86e50 GM22609: - description: "Fibroblast derived from skin from an NF1 patient" + description: Fibroblast derived from skin from an NF1 patient meaning: rrid:CVCL_BU83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f18f5f6b-09c7-4367-89d5-c065137888db" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f18f5f6b-09c7-4367-89d5-c065137888db GM23312: - description: "Tumor-derived cell line from chest an NF1 patient" + description: Tumor-derived cell line from chest an NF1 patient meaning: rrid:CVCL_CW86 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b104c61a-5a55-4811-97fc-7ce0683b2a14" - GM23338: - description: "[From GFF:] iPSC NF1 WT, PGP1 cells" - meaning: rrid:CVCL_F182 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c4e4b03-5975-4708-a25c-f6c45cbe3abf" - GP2d: - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap)." - meaning: rrid:CVCL_2450 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c62fab0b-8aa2-4732-9ffb-7d80b8b425ab" - GWH04: - description: "Mutation of NF1, p.Ter640Argext (c.1918T>C), Unspecified zygosity (PubMed=36169178)." - meaning: rrid:CVCL_C0W3 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=298cca5d-cc3d-4215-968e-8ac5f890ae22" - "HAP1 NF1 (-) 1": - meaning: rrid:CVCL_TA51 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=300695f7-5d65-413f-8f6c-290c4b09f710" - "HAP1 NF1 (-) 2": - meaning: rrid:CVCL_TA52 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72511c95-eaa4-403d-914e-2658e2cabd51" - "HAP1 NF1 (-) 3": - meaning: rrid:CVCL_TA53 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f58179b-18b4-48ee-b3b0-fe8536815838" - "HAP1 NF1 (-) 4": - meaning: rrid:CVCL_TA54 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6d95003f-3800-4d3a-b2fb-a5fbf7adae3c" - "HBE135-E6E7": - description: "[From ATCC:] The HBE135-E6E7 cell line was derived from normal bronchial epithelium taken from a man undergoing lobectomy for squamous cell carcinoma. Cells from the primary explant in their first passage were infected with the recombinant retrovirus LXSN16E6E7 containing the human papilloma virus (HPV) E6E7 gene." - meaning: rrid:CVCL_3695 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a1a3741-0337-4067-95ab-fb0dc9562d66" - "HCT 116": - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0291 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=077ce9fd-c141-4baa-b8ac-80aa2922a041" - "HCT 15": - description: "1 alleles of G13D mutation in KRAS gene" - meaning: rrid:CVCL_0292 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dc12b0e-f9e9-4486-a923-720a8a36bb4e" - HEK293: - description: "[From ATCC:] This is a hypotriploid human cell line." - meaning: rrid:CVCL_0045 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7b6dcc42-3c32-4008-8b2c-309aa01b17be" - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice": - description: "[From GFF:] HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae765b00-9189-4a72-8ae7-cddc41e24055" - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice": - description: "[From GFF:] HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b4b8eca-f981-440d-b478-0a5483353368" - "HEK293 NF1 -/- Exon 47 insT #14": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 47 insT #14" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=130fd347-28e1-46c2-a72d-d243e99322b7" - "HEK293 NF1 -/- Exon 52 R2550X #5": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 52 R2550X #5" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d565aea-0917-428b-9101-d2a19f3fbcf1" - "HEK293 NF1 -/- clone 2": - description: "[From GFF:] HEK293 NF1 -/- clone 2" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f59f3308-a440-497d-8eee-8d7756a9ae2b" - "HEK293 NF1 -/- with R1306X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1306X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02dacc42-ea46-48fb-a4df-7a875d801086" - "HEK293 NF1 -/- with R192X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R192X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb67363f-d309-4c7c-ba1e-f295ba411018" - "HEK293 NF1 -/- with R1947X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1947X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14353c91-2be9-4617-b337-c29080961826" - "HEK293 NF1 -/- with R2550X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R2550X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aa32fc67-9cc3-4d31-bcbd-f7044f9fd484" - "HEK293 NF1 -/- with R461X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R461X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f29aa26-1d05-453a-a6ac-d4e37d609dba" - "HEK293 NF1 -/- with R681X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R681X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=32f73d96-fd2a-4966-a150-ba5fa47d150c" - "HEK293 NF1 -/- with R816X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R816X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f047cff6-98c8-4562-b589-94b864ae35a1" - "HEK293 NF1 -/- with WT mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2d00598-9db3-4549-a473-16b1db349614" - "HEK293 NF1 -/- with WT tagged mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT tagged mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96d339f9-9d19-40c3-8f81-3590f7c00205" - "HPAF-II": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11787853, PubMed=12068308, PubMed=15367885, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0313 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd37b60c-e8f7-451a-87e2-20792451c6fe" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b104c61a-5a55-4811-97fc-7ce0683b2a14 + DD2345: + description: An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line + meaning: rrid:CVCL_9J79 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2e792f78-55b0-4091-9f86-6b78abd920bb HPS1312: meaning: rrid:CVCL_UN64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e85ecf49-5767-41bd-86f8-2c24c3565a14" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e85ecf49-5767-41bd-86f8-2c24c3565a14 HPS1313: meaning: rrid:CVCL_A3UD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f0bb3a66-ad46-4458-bb2a-eb01d5860aaf" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f0bb3a66-ad46-4458-bb2a-eb01d5860aaf HPS1314: meaning: rrid:CVCL_A3UE - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2b29409-3d0c-4ff6-a1d4-eb1ea8e856bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2b29409-3d0c-4ff6-a1d4-eb1ea8e856bb HPS1315: meaning: rrid:CVCL_A3UF - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2c7033c-1cc1-437c-8dd5-699ce1c52c31" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2c7033c-1cc1-437c-8dd5-699ce1c52c31 HPS1316: meaning: rrid:CVCL_A3UG - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=88c655aa-2117-4a84-a15f-ddfa3abcf0e9" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=88c655aa-2117-4a84-a15f-ddfa3abcf0e9 HPS1317: meaning: rrid:CVCL_A3UH - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d1529d1-682a-493f-accf-c498a8a06f29" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d1529d1-682a-493f-accf-c498a8a06f29 HPS2250: meaning: rrid:CVCL_UP04 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85718709-ca03-493c-be51-f63650440435" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85718709-ca03-493c-be51-f63650440435 HPS2251: meaning: rrid:CVCL_A3RL - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d29aaa05-2dae-4f67-b8b1-742d182a6b83" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d29aaa05-2dae-4f67-b8b1-742d182a6b83 HPS2252: meaning: rrid:CVCL_A3RM - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d4806ba-76ec-452c-881b-7a7b48828790" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d4806ba-76ec-452c-881b-7a7b48828790 HPS2253: meaning: rrid:CVCL_A3RN - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b5a2e06e-fd9e-4586-9ab9-4a950815d4c1" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b5a2e06e-fd9e-4586-9ab9-4a950815d4c1 HPS2254: meaning: rrid:CVCL_A3RP - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a687df-afc8-493f-8f5a-a40eceb32946" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a687df-afc8-493f-8f5a-a40eceb32946 HPS2255: meaning: rrid:CVCL_A3RQ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25a6d925-3be3-42d1-8373-e7f8c5fe85aa" - "HS-PSS": - description: "A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be." - meaning: rrid:CVCL_8717 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd49d4e2-575e-4e89-8317-cff02db4882c" - "HS-Sch-2": - description: "A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be." - meaning: rrid:CVCL_8718 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19bba596-fc3d-479b-9675-afa369b44dee" - HS53T: - description: "human NF1-associated MPNST derived cell line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86dcdce8-8416-4157-a31e-04c6edd3ca65" - HSC1λ: - description: "human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0193c87-8813-4841-92e7-ee5095bd94fe" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25a6d925-3be3-42d1-8373-e7f8c5fe85aa + MCRIi020-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d941428a-ebcb-4acf-90ae-107d7cfc52d1 + MCRIi021-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1ME + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a676545-f9b5-4fdb-bf0f-3b68dfdb58b8 + MCRIi022-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MF + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb564630-535a-4d14-8a07-f2b4e64f4926 + MCRIi023-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MG + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8295296a-e1d7-4c9f-beaa-2ac02d09c149 + QQ0588: + description: An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line + meaning: rrid:CVCL_8Y66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53c871d3-6f75-49a6-aa73-42d0ead2298b + RG-137: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B564 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b9d9f06-2918-490e-a783-1655c757d922 + RG-138: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B565 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6e0a7ed-94f6-42e1-9700-6cafcb00f426 + RG-139: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B566 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1dc0e42-68f8-4650-89ac-37a6acdeb10e + RG-140: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B567 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2fe9632c-b6db-443f-a512-4b2523a470e0 + RG-141: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B568 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aba67450-594d-422b-a7fe-6c69a882b859 + RG-235: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA.' + meaning: rrid:CVCL_B653 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=978d317f-f1d6-4039-a2f5-f0787adf589a + RG-315: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T); Heterozygous (ISCR).' + meaning: rrid:CVCL_B721 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0360411b-59dd-457a-ab6f-38a9182c425e + STR-I-437-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y599 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01040031-60ba-4da5-96b0-d4a0a2f9131b + STR-I-441-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y600 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1372bf73-291f-48f9-9207-81120a299675 + STR-I-443-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y601 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5352596f-7192-473c-85b3-2aeb0fbf8e48 + SZ-NF6: + description: 'From: Shaare Zedek Medical Center, The Hebrew University, Jerusalem, Israel., Mutation of NF1, c.4269+1G>C, Unspecified zygosity (Direct author submission)' + meaning: rrid:CVCL_YY00 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7ae798-a355-4b78-b1c3-6c82e3f917a7 + '1507.2': + meaning: rrid:CVCL_1Y71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4304050f-f24a-45b9-9025-8e3e88d0b377 + 10/9CRC1: + meaning: rrid:CVCL_8478 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25c617df-ff54-4ba5-b293-d9fcc9be39ce + 10CM: + description: Mutation of NF1, p.Arg440Ter (c.1318C>T), Unspecified zygosity (PubMed=26744134). Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26744134). + meaning: rrid:CVCL_VJ83 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423cc0f3-8a43-4e10-a9a4-d529aa78f022 + 2XSB: + meaning: rrid:CVCL_A7NI + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f4e4596-0c7d-4d41-b9ff-73ecebd30263 + 4/30PRR: + meaning: rrid:CVCL_8480 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0aed5bf6-d5e2-4a6d-ac3b-a51b5e8bbb8b + 862L: + meaning: rrid:CVCL_8477 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6faf7e00-d770-4527-9384-539f6db31977 + 9/3L: + meaning: rrid:CVCL_8479 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c98ce5c-5cf1-4829-943d-5142073583d8 + Abcam A-549 NF1 KO: + description: Mutation of KRAS, p.Gly12Ser (c.34G>A), Homozygous (from parent cell line). + meaning: rrid:CVCL_B9NJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d605ae2e-969a-4956-bac5-5e36654d7b41 + Abcam HCT 116 NF1 KO: + description: Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (from parent cell line). + meaning: rrid:CVCL_B8LD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5ec9375-0564-414a-94ad-86d5083b440f + Abcam HeLa NF1 KO: + description: Nf1 knockout cell + meaning: rrid:CVCL_B1YJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b26e0c8b-689f-4018-bf27-e2d3a522e039 + Abcam MCF-7 NF1 KO: + description: Nf1 knockout cell + meaning: rrid:CVCL_B8ZE + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24719e11-8ac2-452c-9424-20d75fc26d82 + Abcam U-87MG SNCA KO: + description: Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line). + meaning: rrid:CVCL_C0BJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5f5d4a-95f7-4e5c-9db1-d13fbc9748a7 + AMC-106: + meaning: rrid:CVCL_9477 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf77b1e3-93be-4b4e-bc34-85d8b9d06a81 + BayGenomics ES cell line XF344: + description: Nf1 knockout cell + meaning: rrid:CVCL_PR85 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=60633d59-0230-47c3-9d40-08b0ae194b6d + CML-6M: + description: Pigmented. Mutation of NF1, p.Pro1599fs (c.4795delCinsTT), Heterozygous (PubMed=31175136). + meaning: rrid:CVCL_0D24 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=acd954de-1f36-41ad-8ce0-ac738aa840ba + CPTC-NF1-1: + meaning: rrid:CVCL_C2NU + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65d07476-2469-4679-85b2-e2ca67f3b01b + CPTC-NF1-2: + meaning: rrid:CVCL_C2NV + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f410431d-7571-4302-8870-eb115b71d0ce + CPTC-NF1-3: + meaning: rrid:CVCL_C2NW + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42257ac4-1950-4541-9bee-b9a965e2fa86 + CTV-1: + description: Mutation of NF1, p.Gly1532Arg (c.4594G>A), Heterozygous (PubMed=22675565, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1150 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37cbf7b9-f74c-4407-8541-86c17e394c5d + D-566MG: + description: Mutation of NF1, p.Ile941Serfs*13 (c.2820delC), Heterozygous (Cosmic-CLP). + meaning: rrid:CVCL_1166 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc7c0fee-8a89-49a2-b58c-eff50448006d + FMS-1: + meaning: rrid:CVCL_IS33 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b14a6ae1-829c-4ae3-9149-9fcf6cc6c57d + FTC-133: + description: Has a near-homozygous genome (NHG). Mutation of NF1, p.Cys167Ter (c.501T>A), Homozygous (PubMed=30737244). + meaning: rrid:CVCL_1219 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a630172-cf98-41c1-ae06-c436900fb513 + FU-SFT8710: + meaning: rrid:CVCL_ZE77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b96c1fa0-5284-424a-b29e-338db3c8b292 + GI-ME-N: + description: Gene deletion, NF1, Heterozygous (PubMed=20655465). Mutation of NF1, Microdeletion, Heterozygous (PubMed=20655465). + meaning: rrid:CVCL_1232 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe5b49ff-6d77-4de3-adc3-0fc97fd076e4 + GI-ME-NrCDDP500: + description: Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line). + meaning: rrid:CVCL_RS22 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=73b8caeb-cc91-4d81-b076-25d611949807 + GI-ME-NrDOX5: + description: Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line). + meaning: rrid:CVCL_RS07 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a03250ca-0914-4318-b5c6-5b5a86ca1965 + GI-ME-NrVCR14: + description: Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line). + meaning: rrid:CVCL_RR32 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25fa8030-970e-48ec-8e22-55e23a747164 + GM10501: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R95 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb + GM10502: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R96 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965 + GM10657: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R97 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7 + GM10659: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R98 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3 + GM12517: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1S66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81 + GWH04: + description: Mutation of NF1, p.Ter640Argext (c.1918T>C), Unspecified zygosity (PubMed=36169178). + meaning: rrid:CVCL_C0W3 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=298cca5d-cc3d-4215-968e-8ac5f890ae22 + HAP1 NF1 (-) 1: + meaning: rrid:CVCL_TA51 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=300695f7-5d65-413f-8f6c-290c4b09f710 + HAP1 NF1 (-) 2: + meaning: rrid:CVCL_TA52 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72511c95-eaa4-403d-914e-2658e2cabd51 + HAP1 NF1 (-) 3: + meaning: rrid:CVCL_TA53 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f58179b-18b4-48ee-b3b0-fe8536815838 + HAP1 NF1 (-) 4: + meaning: rrid:CVCL_TA54 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6d95003f-3800-4d3a-b2fb-a5fbf7adae3c HTh74: - description: "Established from a tumor implanted into a nude mice. Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (PubMed=30737244)." + description: Established from a tumor implanted into a nude mice. Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (PubMed=30737244). meaning: rrid:CVCL_6288 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ace6c78c-3ea6-426d-83b3-1ceeecd74db3" - "HTh74 clone 7": - description: "Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ace6c78c-3ea6-426d-83b3-1ceeecd74db3 + HTh74 clone 7: + description: Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (from parent cell line). meaning: rrid:CVCL_AT82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d86c2e88-3de9-4c0f-9cb5-de2921b8207f" - "HeLa SilenciX NF1": - description: "HeLa cervical cancer cells with stable (EBV-based siRNA) knockdown of the NF1 gene." - meaning: rrid:CVCL_KT82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2549e536-b033-43e4-acf6-501499b6e498" - "HuP-T4": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1300 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1e7bf984-5c1f-463e-89e1-b5d9b552aef5" - "JH-2-002": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1bc84ef2-208f-4f0e-8045-6be47fd968de" - "JH-2-009": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0bc812b4-f2af-40c4-8245-1070ab12f627" - "JH-2-031": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4241b7ff-c08e-4c6d-b2c1-9de9ac91f72b" - KCL024: - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_A257 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5fdcfb8-24e7-46fa-9f48-bcbae8a90b7a" - KCL025: - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_A258 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=18ba4c2e-e8d5-4032-a6ab-d0fca3f0f984" - "KOMP ES cell line Nf1": - description: "JM8.F6 derived from C57BL/6N" - meaning: "rrid:MMRRC_059313-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d596eb56-33b0-4dcc-b7e4-0922a93c4134" - "KOMP ES cell line Nf1": - description: "JM8.F6 derived from C57BL/6N" - meaning: "rrid:MMRRC_059314-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e0a4cc28-022b-48ed-acf5-28ee38eb20bd" - "KP-3": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=21607521, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_3005 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a550816-e561-4d4b-a25c-995ea23b8a41" - "LCLC-97TM1": - description: "2 alleles of G12V mutation in KRAS gene" - meaning: rrid:CVCL_1376 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7fe3fbf-d242-40b6-9d33-c19e8e0057e0" - LS180: - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=20570890, PubMed=24755471, ATCC)." - meaning: rrid:CVCL_0397 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54b8989a-e04f-47ac-bc0c-a5871b943228" - LS513: - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471)." - meaning: rrid:CVCL_1386 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f95c38-f30f-4ce8-8a92-97baecbc53fc" - Lis42_NF1_1N: - description: "Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1." - meaning: rrid:CVCL_Y368 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd38ffda-2db1-47f0-af6f-8de572e06037" - Lis47_NF1_2N: - description: "Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1." - meaning: rrid:CVCL_Y373 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0ca95f1-a3d9-4641-b47d-84346d9ec04a" - LoVo: - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0399 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5ce9c8-7f59-43b0-ac57-3a883d75dff3" - "Lu-65": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1392 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6365e6d0-eefd-4778-9e0f-d8c549838ff2" - "Lu-99": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap)." - meaning: rrid:CVCL_3015 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31448c47-8e6d-412c-917a-9f92c53ad687" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d86c2e88-3de9-4c0f-9cb5-de2921b8207f MCF10A_NF1_1: meaning: rrid:CVCL_C1A6 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd6b1f88-b716-47d4-9869-84d58b18c2eb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd6b1f88-b716-47d4-9869-84d58b18c2eb MCF10A_NF1_7A1: meaning: rrid:CVCL_C1A7 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f506b298-5b5e-4ea6-abe3-49b4f69d871b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f506b298-5b5e-4ea6-abe3-49b4f69d871b MCF10A_NF1_7B2: meaning: rrid:CVCL_C1A8 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7e0c9b3-008d-415f-bd1e-8fc33d55e497" - "MCRIi020-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1MD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d941428a-ebcb-4acf-90ae-107d7cfc52d1" - "MCRIi021-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1ME - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a676545-f9b5-4fdb-bf0f-3b68dfdb58b8" - "MCRIi022-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1MF - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb564630-535a-4d14-8a07-f2b4e64f4926" - "MCRIi023-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1MG - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8295296a-e1d7-4c9f-beaa-2ac02d09c149" - "MH/Nike": - description: "Mutation of NF1, p.Ala2176fs (c.6525delG), Homozygous (PubMed=31175136)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7e0c9b3-008d-415f-bd1e-8fc33d55e497 + Mes-9: + meaning: rrid:CVCL_H658 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b61a902-c96f-4849-abd3-7631963e1cc5 + MH/Nike: + description: Mutation of NF1, p.Ala2176fs (c.6525delG), Homozygous (PubMed=31175136). meaning: rrid:CVCL_DN29 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cb659ee-8d25-4016-a2a5-4c230bfc933e" - "MIA PaCa-2": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=7961102, PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=12068308, PubMed=21607521, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0428 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee325d43-d215-4610-aa67-011ea95efaab" - "MPNST 724": - description: "human MPNST cell line" - meaning: rrid:CVCL_AU20 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7db6b49f-7eec-4b47-bbdc-675a8a464735" - "MPNST-14": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cb659ee-8d25-4016-a2a5-4c230bfc933e + MPNST-14: meaning: rrid:CVCL_AU21 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=81ae2a05-5102-473f-88fa-9d9bbe8fd35e" - "MPNST-642": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=81ae2a05-5102-473f-88fa-9d9bbe8fd35e + MPNST-642: meaning: rrid:CVCL_AU19 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=818f4c93-dbd3-41f7-b557-f264f7949c6e" - "MPNST-90": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=818f4c93-dbd3-41f7-b557-f264f7949c6e + MPNST-90: meaning: rrid:CVCL_J355 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd3db98f-0ec9-40df-bc06-5e314c0fc671" - "MPNST-91": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd3db98f-0ec9-40df-bc06-5e314c0fc671 + MPNST-91: meaning: rrid:CVCL_J356 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fd09582-99a8-40d5-a16b-b250a6975e44" - "MPNST-92": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fd09582-99a8-40d5-a16b-b250a6975e44 + MPNST-92: meaning: rrid:CVCL_J357 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa12d6e9-6547-43ad-a666-c17c7c1a9cb3" - "MUG-Mel1": - description: "Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa12d6e9-6547-43ad-a666-c17c7c1a9cb3 + MUG-Mel1: + description: Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407). meaning: rrid:CVCL_VV72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce4f191-b7ce-437d-8cef-f6de332040e0" - "MUG-Mel1 clone C8": - description: "Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce4f191-b7ce-437d-8cef-f6de332040e0 + MUG-Mel1 clone C8: + description: Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407). meaning: rrid:CVCL_VV73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=590ebb66-5944-4cf7-accc-23e18d6c3818" - "MUG-Mel1 clone D5": - description: "Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=590ebb66-5944-4cf7-accc-23e18d6c3818 + MUG-Mel1 clone D5: + description: Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407). meaning: rrid:CVCL_VV74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96f2ab08-2c90-4ef9-9d56-1705ee49cecc" - "Mes-9": - meaning: rrid:CVCL_H658 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b61a902-c96f-4849-abd3-7631963e1cc5" - N10: - description: "N5 and N10 cells lines underwent CRISPR/Cas9 targeting against NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de94c5d9-6feb-402f-a0c6-6ac3389907c6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96f2ab08-2c90-4ef9-9d56-1705ee49cecc N206: meaning: rrid:CVCL_C885 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6cbf7434-7dd5-4ed5-9ca6-77e65e2b4b36" - "NB90-4": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6cbf7434-7dd5-4ed5-9ca6-77e65e2b4b36 + NB90-4: meaning: rrid:CVCL_A5PQ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9bacf245-10fb-48b1-ae87-1034bd1259a0" - "NB90-6": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9bacf245-10fb-48b1-ae87-1034bd1259a0 + NB90-6: meaning: rrid:CVCL_A5PR - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fdfba143-b6fe-494f-ae25-8796009e8090" - "NCC-MPNST1-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU12 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc3ae45e-9a5b-4fa5-8430-f53479f07f5a" - "NCC-MPNST2-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU13 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f646e44-5263-4f80-bb94-b297a875c52a" - "NCC-MPNST3-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU14 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7fe31236-bc93-449b-b559-9394999be926" - "NCC-MPNST3-X2-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU15 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b604846-d41c-4969-a79a-9660c04e585c" - "NCC-MPNST4-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU16 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f17b839e-acd9-4dbc-a5bb-7d72ed0d0bd8" - "NCC-MPNST5-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU17 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=827f08a1-3d0f-4fd8-98e4-fb5c40a9c742" - "NCI-H1373": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, DepMap)." - meaning: rrid:CVCL_1465 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a14754e6-1c26-4224-9ef9-a1abfd1538eb" - "NCI-H1385": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap)." - meaning: rrid:CVCL_1466 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=93469888-1234-4f52-b3a7-175423b817cc" - "NCI-H1651": - description: "Mutation of NF1, p.Arg997fs*15 (c.2990delG), Heterozygous (Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fdfba143-b6fe-494f-ae25-8796009e8090 + NCI-H1651: + description: Mutation of NF1, p.Arg997fs*15 (c.2990delG), Heterozygous (Cosmic-CLP, DepMap). meaning: rrid:CVCL_1484 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c82d4706-1c04-46d2-9d23-6b5a7fc24767" - "NCI-H1792": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1495 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d28192f0-d180-40e1-b184-de3fed398e72" - "NCI-H1838": - description: "Mutation of NF1, p.Asn184fs*17 (c.548_549insA), Heterozygous (Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c82d4706-1c04-46d2-9d23-6b5a7fc24767 + NCI-H1838: + description: Mutation of NF1, p.Asn184fs*17 (c.548_549insA), Heterozygous (Cosmic-CLP, DepMap). meaning: rrid:CVCL_1499 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7008ce3-09ef-4150-a793-69bdde435b66" - "NCI-H1944": - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1508 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e3ae7e3f-d6ae-48d9-8e08-e2625c048642" - "NCI-H2030": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1517 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177c35b5-d859-4bf2-870b-9311ef059159" - "NCI-H2122": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1531 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=12d08160-d127-463a-9e6e-c62347f9e756" - "NCI-H23": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=17088437)." - meaning: rrid:CVCL_1547 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95e9ea19-3d84-43a5-b003-347ecec6b1fa" - "NCI-H2444": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1552 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=da179d37-bc2d-4725-8621-f8ec49b917d0" - "NCI-H358": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=9649128, PubMed=12068308)." - meaning: rrid:CVCL_1559 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cca5b217-ce0b-4c2b-814f-54fefb967475" - "NCI-H441": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1561 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=665f978b-9fec-4f0b-8921-058a94b84bcd" - "NCI-H647": - description: "2 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1574 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df53b267-e448-4051-a0d8-1db4da3c5c41" - "NCI-H727": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1584 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d124e590-59ba-44c6-9c9f-0b0a3c96862c" - "NCI-H747": - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1587 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06004dd0-1122-46cc-b049-8349d9511c64" - NF1: - description: "Cell line from an NF1 patient; unclear if derived from tumor or non-tumor tissue." - meaning: rrid:CVCL_JG80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a8a362e-e3be-4bc3-be7e-d0a0865b9c31" - "NF1+/- hiPSC-SCPs": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa3052b-d40a-4f73-b12e-b68c472497bb" - "NF1-/- hiPSC-SCPs": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc7520bc-3deb-43c2-81e9-b71cbf4daa65" - "NF1-R68X Embryonic cells": - description: "[From GFF:] NF1-R68X Embryonic cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90748442-be62-44f1-899e-804cd5600823" - NF10.1: - description: "NF1-deficient MPNST tumor cell line from an NF1 patient." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2e468b4-b8cf-4473-b5f5-b7f47415d40f" - NF11.1: - description: "NF1-deficient MPNST tumor cell line from an NF1 patient." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc674458-affb-46a3-8a48-90fe556b44d1" - "NF1C-FiPS-SV4F7": - description: "NF1(-/-) iPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=00f8dcc6-a2b2-4fc2-a327-e87367bffa21" - NF1‐iN: - description: "fibroblasts cell lines from a NF1 patient" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e608c5ee-fd65-4a08-9c89-9bf16f83956f" - "NFS-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7008ce3-09ef-4150-a793-69bdde435b66 + NFS-1: meaning: rrid:CVCL_1Y69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e6866e8-c67d-4650-a0a3-a10a5a8bdb49" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e6866e8-c67d-4650-a0a3-a10a5a8bdb49 NGP: meaning: rrid:CVCL_2141 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd026e3f-c345-4e67-8d79-31c1cd295a25" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd026e3f-c345-4e67-8d79-31c1cd295a25 NMB: meaning: rrid:CVCL_2143 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49286dfd-632c-4f62-834f-d1441e05fde5" - "NMS-2": - description: "human MPNST cell lines" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49286dfd-632c-4f62-834f-d1441e05fde5 + NMS-2: + description: human MPNST cell lines meaning: rrid:CVCL_4662 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=83512f26-8cc3-48db-8f66-1b490a943eb1" - "NMS-2PC": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=83512f26-8cc3-48db-8f66-1b490a943eb1 + NMS-2PC: meaning: rrid:CVCL_L810 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50b33e18-9c4a-470c-b982-7f612be9a79b" - "NMS-PC": - description: "human MPNST cell lines" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c7fb76f-0aae-4e0c-9a69-f50f6a5c5ebb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50b33e18-9c4a-470c-b982-7f612be9a79b NZM022: - description: "Mutation of NF1, p.Arg1362Ter (c.4084C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Arg1362Ter (c.4084C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_D825 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14569691-bdb1-4cd7-ae1c-943f100e93ff" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14569691-bdb1-4cd7-ae1c-943f100e93ff NZM041: - description: "Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_S426 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d017560-faf4-4230-a9cb-b9e742b158c4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d017560-faf4-4230-a9cb-b9e742b158c4 NZM047: - description: "Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_S424 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=416e4ab2-7916-4853-9cf8-4ff76aec072a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=416e4ab2-7916-4853-9cf8-4ff76aec072a NZM072: - description: "Mutation of NF1, p.Arg416Ter (c.1246C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Arg416Ter (c.1246C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_0D36 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb8aed26-e95a-4b7d-b4fb-d4b9f1847c9c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb8aed26-e95a-4b7d-b4fb-d4b9f1847c9c NZM077: - description: "Mutation of NF1, p.Pro1323Ser (c.3967C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Pro1323Ser (c.3967C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_0D40 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0b08c4c-2662-47b2-9eb0-306a8871f92e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0b08c4c-2662-47b2-9eb0-306a8871f92e NZM087: - description: "Mutation of NF1, p.His1170Tyr, Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.His1170Tyr, Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_0D47 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84d5c1ae-b82b-4b80-ab7a-3884c8efafda" - "Nf1-/- Epithelial lung cells": - description: "[From GFF:] Nf1-/- Epithelial lung cells, derived from HBE135-E6E7 epithelial lung cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=779714c8-f522-4355-a502-d5d2e6e09afa" - "Nf1-/- HEK 293": - description: "[From GFF:] Nf1-/- HEK 293" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=44f9c496-ddd8-4e4b-bddb-6b93f7e04fc2" - "Nf1-/- skin-derived precursor cells": - description: "[From GFF:] Nf1-/- skin-derived precursor cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=15c3bd82-9791-4a53-b6f7-4d23b882a285" - "Nf1Arg681*/+ ES": - description: "[From GFF:] Nf1Arg681*/+ ES" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ff97eee-5c1a-4439-9df6-d1715cbdd189" - "Nf1Arg681*/Arg681* ES": - description: "[From GFF:] Nf1Arg681*/Arg681* ES" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=70c1e3f6-751f-49e4-aa47-e3bea4aeac43" - "Nf1Arg681*/Arg681* MEFs": - description: "[From GFF:] Nf1Arg681*/Arg681* MEFs" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47f50ef0-8d59-430d-9d05-7df1a4f41c3b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84d5c1ae-b82b-4b80-ab7a-3884c8efafda OSW: - description: "Mutation of NF1, p.Asn58fs (c.167delA), Homozygous (PubMed=31175136)." + description: Mutation of NF1, p.Asn58fs (c.167delA), Homozygous (PubMed=31175136). meaning: rrid:CVCL_0B19 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a62af66-384d-419b-b8ac-f4d381b85942" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a62af66-384d-419b-b8ac-f4d381b85942 PEO4: - description: "Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (CelloPub=CLPUB00667, DepMap)." + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (CelloPub=CLPUB00667, DepMap). meaning: rrid:CVCL_2690 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb0770ce-7733-41e5-8ca3-d1abfbe44a31" - "PEO4-iPSC-OSKM-03": - description: "Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb0770ce-7733-41e5-8ca3-d1abfbe44a31 + PEO4-iPSC-OSKM-03: + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line). meaning: rrid:CVCL_B7JI - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7126593e-4b96-40a5-9ff4-d41b81fbba4c" - "PEO4-iPSC-OSKM-05": - description: "Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7126593e-4b96-40a5-9ff4-d41b81fbba4c + PEO4-iPSC-OSKM-05: + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line). meaning: rrid:CVCL_B7JJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f103987e-5196-440e-a6ba-53d39305c714" - "PK-1": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap)." - meaning: rrid:CVCL_4717 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53f296e1-638f-44af-8a6f-e9dd601586b0" - "PK-45H": - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (DepMap)." - meaning: rrid:CVCL_6748 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e18db26-a0c8-4418-8c64-a73d3fa7e8af" - "PK-59": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap)." - meaning: rrid:CVCL_4897 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f1d08c5-73a8-47e5-b113-031c6a55316d" - "PNET-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f103987e-5196-440e-a6ba-53d39305c714 + PNET-1: meaning: rrid:CVCL_A5PP - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65a74b6e-bede-4228-a43d-3939f2c6311a" - "PNET-2": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65a74b6e-bede-4228-a43d-3939f2c6311a + PNET-2: meaning: rrid:CVCL_4432 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45cf8733-b0c2-433e-b5fc-abd3a0748b79" - "PaTu 8902": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1845 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ead740e0-7ced-4d3c-b411-207cd8f7ae74" - "Panc 02.03": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1633 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21237832-d6ba-422e-80ec-36a3ae6d7c7a" - "Panc 03.27": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1635 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2acf94e6-185b-4717-8f04-71ac8b6d62e3" - "Panc 04.03": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1636 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177e4c5c-f9dd-4695-a3ca-fb9205aae724" - "Panc 08.13": - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=9612602, ATCC)." - meaning: rrid:CVCL_1638 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d861eabe-95d4-47d7-bbb9-be13f7db26f6" - "Panc 10.05": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1639 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf2cfa90-a8cd-4ae4-ad5d-2ab86eddd313" - "QGP-1": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=21607521, PubMed=29444910, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_3143 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3b46e6a-030c-4f5e-8d86-d0f540d31edb" - QQ0588: - description: "An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line" - meaning: rrid:CVCL_8Y66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53c871d3-6f75-49a6-aa73-42d0ead2298b" - "RCM-1": - description: "2 alleles of G12V mutation in KRAS gene. Mutation, KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1648 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c003a385-2de1-4ee8-a2d3-212bb746dac9" - "RERF-LC-Ad2": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (DepMap)." - meaning: rrid:CVCL_1652 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6cb07c1-218d-4762-90d9-4de228447635" - "RG-137": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B564 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b9d9f06-2918-490e-a783-1655c757d922" - "RG-138": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B565 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6e0a7ed-94f6-42e1-9700-6cafcb00f426" - "RG-139": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B566 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1dc0e42-68f8-4650-89ac-37a6acdeb10e" - "RG-140": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B567 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2fe9632c-b6db-443f-a512-4b2523a470e0" - "RG-141": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B568 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aba67450-594d-422b-a7fe-6c69a882b859" - "RG-235": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA." - meaning: rrid:CVCL_B653 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=978d317f-f1d6-4039-a2f5-f0787adf589a" - "RG-315": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T); Heterozygous (ISCR)." - meaning: rrid:CVCL_B721 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0360411b-59dd-457a-ab6f-38a9182c425e" - S462: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_1Y70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2fb9f7e-ea11-404f-8c0c-c9dc36367f2d" - S462.TY: - description: "MPNST tumor cell line from an NF1 patient, created by passaging S462 cell line in mice as xenografts." - meaning: rrid:CVCL_JK02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6a101aa-9ca8-4191-9b43-eddf327ea48b" - S462s: - description: "Human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c655750-7b47-4cd1-bc5d-2bc6246f5e26" - S462sp: - description: "MPNST-derived cell line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ab6c976-dbd3-4616-9911-23f4981fa5c5" - S520: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_AX35 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0a60dec-8ead-43c5-abc2-b06b89dd20cd" - "SHG-140": - description: "Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T), Homozygous (PubMed=33391433)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45cf8733-b0c2-433e-b5fc-abd3a0748b79 + SHG-140: + description: Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T), Homozygous (PubMed=33391433). meaning: rrid:CVCL_A0XC - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa66c45-c7b1-4a85-bfe9-79bb0a1334a7" - "SHP-77": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1693 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b177ff32-b33c-4327-8862-e5b23994b502" - "SIGTR ES cell line AA0320": - description: "High throughput gene trapping was performed by inserting a gene trap vector containing a splice-acceptor sequence upstream of a reporter gene, β-geo (a fusion of β-galactosidase and neomycin phosphotransferase II), into an intronic or coding region of genomic DNA. The resulting insertional mutation creates a fusion transcript containing sequences from exons upstream of the insertion joined to the β-geo marker, allowing cell lines where the vector has successfully interrupted a gene to be identified." - meaning: "rrid:MMRRC_025689-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8a75443-a92f-45f7-9290-0669405e2e9c" - "SJNB-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa66c45-c7b1-4a85-bfe9-79bb0a1334a7 + SJNB-1: meaning: rrid:CVCL_8812 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e1d0a02-22cc-489a-851c-c7b9955a6270" - "SJNB-10": - description: "Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e1d0a02-22cc-489a-851c-c7b9955a6270 + SJNB-10: + description: Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465). meaning: rrid:CVCL_1441 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7bcdcae-52d3-4bc5-af24-243483588ee5" - "SJNB-12": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7bcdcae-52d3-4bc5-af24-243483588ee5 + SJNB-12: meaning: rrid:CVCL_1442 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6bcc8ec-3169-4e4f-afbb-fbca2658007c" - "SJNB-13": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6bcc8ec-3169-4e4f-afbb-fbca2658007c + SJNB-13: meaning: rrid:CVCL_1443 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1785a08d-ce83-45f6-bba8-68f4b0d3514c" - "SJNB-14": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1785a08d-ce83-45f6-bba8-68f4b0d3514c + SJNB-14: meaning: rrid:CVCL_1444 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae35c72c-7fd9-463b-9b0d-fb4670ccf05e" - "SJNB-16": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae35c72c-7fd9-463b-9b0d-fb4670ccf05e + SJNB-16: meaning: rrid:CVCL_8815 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce47dba5-1303-4253-af99-3e16cc14a341" - "SJNB-19": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce47dba5-1303-4253-af99-3e16cc14a341 + SJNB-19: meaning: rrid:CVCL_8817 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d45b694e-00fc-481a-96d5-c081941d14f5" - "SJNB-2": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d45b694e-00fc-481a-96d5-c081941d14f5 + SJNB-2: meaning: rrid:CVCL_8818 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=965771a4-c863-4e89-a9db-d160d1e4c5e5" - "SJNB-3": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=965771a4-c863-4e89-a9db-d160d1e4c5e5 + SJNB-3: meaning: rrid:CVCL_8820 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c87d24ac-439e-404a-9a43-6110c497599e" - "SJNB-4": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c87d24ac-439e-404a-9a43-6110c497599e + SJNB-4: meaning: rrid:CVCL_8821 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1d2aa58f-2aaa-44ca-96e0-e37231052451" - "SJNB-5": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1d2aa58f-2aaa-44ca-96e0-e37231052451 + SJNB-5: meaning: rrid:CVCL_8822 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9634dff-4e4e-4cd9-bfe9-3d23e7d40583" - "SJNB-6": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9634dff-4e4e-4cd9-bfe9-3d23e7d40583 + SJNB-6: meaning: rrid:CVCL_8823 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9c45c5d-8707-437e-ab75-a8135e95b45d" - "SJNB-7": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9c45c5d-8707-437e-ab75-a8135e95b45d + SJNB-7: meaning: rrid:CVCL_8824 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e6aae84-e57c-4c1d-9ce7-24a03026b435" - "SJNB-8": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e6aae84-e57c-4c1d-9ce7-24a03026b435 + SJNB-8: meaning: rrid:CVCL_8825 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=742d8193-6e25-4f0f-adc7-5dc881727673" - "SJNB-9": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=742d8193-6e25-4f0f-adc7-5dc881727673 + SJNB-9: meaning: rrid:CVCL_8826 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abfc2e7c-0d28-422f-9973-74b5fb66b402" - "SK-CO-1": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0626 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e7d6716-540f-4206-a32e-4b7ca4b4c53e" - "SK-LU-1": - description: "1 alleles of G12D mutation in KRAS gene. Cell line positive for alternative lengthening of telomeres (ALT+). Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=1855224, PubMed=12068308, PubMed=12794755, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0629 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=903d9857-0c45-4817-a8d6-b43490a3fbcb" - "SK-MEL-105": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abfc2e7c-0d28-422f-9973-74b5fb66b402 + SK-MEL-105: meaning: rrid:CVCL_6070 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b6cfa68c-9b94-4c77-8ef2-6753e595ea59" - "SK-MEL-109": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b6cfa68c-9b94-4c77-8ef2-6753e595ea59 + SK-MEL-109: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6073 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c8c2065-4781-4275-88bc-c300d6fce45a" - "SK-MEL-11": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c8c2065-4781-4275-88bc-c300d6fce45a + SK-MEL-11: meaning: rrid:CVCL_D702 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be7ecfd3-30cc-4ed3-b923-92ad62970441" - "SK-MEL-110": - description: "Mutation of KRAS, p.Glu63Lys (c.187G>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be7ecfd3-30cc-4ed3-b923-92ad62970441 + SK-MEL-110: + description: Mutation of KRAS, p.Glu63Lys (c.187G>A), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_3875 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e1a6df94-feec-421c-a865-12d27212fd62" - "SK-MEL-113": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e1a6df94-feec-421c-a865-12d27212fd62 + SK-MEL-113: meaning: rrid:CVCL_6074 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eabae967-3d0b-4d26-848f-83e0b7d3f646" - "SK-MEL-117": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eabae967-3d0b-4d26-848f-83e0b7d3f646 + SK-MEL-117: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6075 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42c32d24-0d9e-48f9-84fe-6b68ea76d4b3" - "SK-MEL-118": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42c32d24-0d9e-48f9-84fe-6b68ea76d4b3 + SK-MEL-118: meaning: rrid:CVCL_6076 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a92babaf-c310-4c73-8d35-c8942a60272c" - "SK-MEL-119": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=10766161, PubMed=15009714, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a92babaf-c310-4c73-8d35-c8942a60272c + SK-MEL-119: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=10766161, PubMed=15009714, PubMed=24576830). meaning: rrid:CVCL_6077 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=67795a20-8d41-4a1c-a79d-ee6b4e02b00f" - "SK-MEL-12": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=67795a20-8d41-4a1c-a79d-ee6b4e02b00f + SK-MEL-12: meaning: rrid:CVCL_6021 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a739a670-527d-4be6-9e3a-66366b8a5242" - "SK-MEL-127": - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a739a670-527d-4be6-9e3a-66366b8a5242 + SK-MEL-127: + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6078 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08684da1-cd81-4616-baef-5b37ee641eb3" - "SK-MEL-13": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08684da1-cd81-4616-baef-5b37ee641eb3 + SK-MEL-13: meaning: rrid:CVCL_6022 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7765fe-7681-40cb-8a72-6f6d5204985e" - "SK-MEL-130": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7765fe-7681-40cb-8a72-6f6d5204985e + SK-MEL-130: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6080 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e9b741c-b0af-4c12-a1c0-9dd23facb95e" - "SK-MEL-131": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e9b741c-b0af-4c12-a1c0-9dd23facb95e + SK-MEL-131: meaning: rrid:CVCL_6081 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=091b8721-27f6-4a7b-ab85-833aa57a61c3" - "SK-MEL-133": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=091b8721-27f6-4a7b-ab85-833aa57a61c3 + SK-MEL-133: meaning: rrid:CVCL_6082 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=896db229-428a-447b-b37d-b2b7c405545d" - "SK-MEL-146": - description: "Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=896db229-428a-447b-b37d-b2b7c405545d + SK-MEL-146: + description: Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_6085 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=80e1cac7-712d-4333-9d09-27e8cce3d46d" - "SK-MEL-15": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=80e1cac7-712d-4333-9d09-27e8cce3d46d + SK-MEL-15: meaning: rrid:CVCL_6964 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d269f40c-b3e7-4dc7-9c40-28ba1f9711cf" - "SK-MEL-153": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d269f40c-b3e7-4dc7-9c40-28ba1f9711cf + SK-MEL-153: meaning: rrid:CVCL_6087 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be99815b-bab0-49e1-b281-3163d4c34be5" - "SK-MEL-161": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be99815b-bab0-49e1-b281-3163d4c34be5 + SK-MEL-161: meaning: rrid:CVCL_6088 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615ef245-4753-4a2d-9e37-013f5c0411c4" - "SK-MEL-170": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615ef245-4753-4a2d-9e37-013f5c0411c4 + SK-MEL-170: meaning: rrid:CVCL_6089 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3e11e0d-a7bf-491e-badd-88404b403caf" - "SK-MEL-174": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3e11e0d-a7bf-491e-badd-88404b403caf + SK-MEL-174: meaning: rrid:CVCL_6091 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54970293-b923-4058-baee-abea1f0154e8" - "SK-MEL-176": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54970293-b923-4058-baee-abea1f0154e8 + SK-MEL-176: meaning: rrid:CVCL_6092 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e712f46a-4e8d-48bd-87e6-1329b358e178" - "SK-MEL-178": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e712f46a-4e8d-48bd-87e6-1329b358e178 + SK-MEL-178: meaning: rrid:CVCL_6093 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3ad8165-42aa-4e9b-8403-3df16139b535" - "SK-MEL-181": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3ad8165-42aa-4e9b-8403-3df16139b535 + SK-MEL-181: meaning: rrid:CVCL_6094 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a71bce03-eef0-422c-b327-6c79cf634bbe" - "SK-MEL-182": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a71bce03-eef0-422c-b327-6c79cf634bbe + SK-MEL-182: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6095 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0b3d75cd-ed20-4fe4-b588-317a870ca687" - "SK-MEL-186": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0b3d75cd-ed20-4fe4-b588-317a870ca687 + SK-MEL-186: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6096 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2d5cbfd-18e1-4755-b2e9-1d3df322aa60" - "SK-MEL-188": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2d5cbfd-18e1-4755-b2e9-1d3df322aa60 + SK-MEL-188: description: Pigmented. meaning: rrid:CVCL_6098 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2df52df1-44ae-4897-afc9-cbbc997a73ca" - "SK-MEL-190": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2df52df1-44ae-4897-afc9-cbbc997a73ca + SK-MEL-190: meaning: rrid:CVCL_6099 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1dff78ed-20a6-4df8-ba2c-4979eef85cf8" - "SK-MEL-191": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1dff78ed-20a6-4df8-ba2c-4979eef85cf8 + SK-MEL-191: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6100 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=446e95ac-2716-4a3b-8294-74f1a3ba38b0" - "SK-MEL-196": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=446e95ac-2716-4a3b-8294-74f1a3ba38b0 + SK-MEL-196: meaning: rrid:CVCL_6102 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3967dcb7-a32f-4437-bc30-21e9d1b27d5b" - "SK-MEL-199": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3967dcb7-a32f-4437-bc30-21e9d1b27d5b + SK-MEL-199: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6104 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=545a4d43-e5ec-4989-9f7f-f5274248072c" - "SK-MEL-200": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=545a4d43-e5ec-4989-9f7f-f5274248072c + SK-MEL-200: meaning: rrid:CVCL_6105 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4ce28266-8fbc-48f1-8e17-35719865102d" - "SK-MEL-202": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4ce28266-8fbc-48f1-8e17-35719865102d + SK-MEL-202: meaning: rrid:CVCL_6106 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=389f4f77-8faf-46b8-9ae2-91e26844bfc3" - "SK-MEL-205": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=389f4f77-8faf-46b8-9ae2-91e26844bfc3 + SK-MEL-205: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6107 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d557680-ae5b-4345-8742-d0cc4a6318a2" - "SK-MEL-207": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d557680-ae5b-4345-8742-d0cc4a6318a2 + SK-MEL-207: meaning: rrid:CVCL_6108 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f02bdc8-5936-495a-af4b-0b94b14dfe2c" - "SK-MEL-208": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f02bdc8-5936-495a-af4b-0b94b14dfe2c + SK-MEL-208: meaning: rrid:CVCL_6109 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8801096-624b-463a-90b3-143a4dd8d504" - "SK-MEL-209": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8801096-624b-463a-90b3-143a4dd8d504 + SK-MEL-209: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6110 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a56209e-d090-4f66-bf8c-66eafa35bcfe" - "SK-MEL-21": - description: "Very highly pigmented. Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a56209e-d090-4f66-bf8c-66eafa35bcfe + SK-MEL-21: + description: Very highly pigmented. Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_3877 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4d34543-1c7d-4c58-adf7-3f60a1df91d4" - "SK-MEL-210-3": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4d34543-1c7d-4c58-adf7-3f60a1df91d4 + SK-MEL-210-3: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_D772 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f23a835-e46f-4e7e-9643-1ad7264ca35d" - "SK-MEL-215-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f23a835-e46f-4e7e-9643-1ad7264ca35d + SK-MEL-215-1: meaning: rrid:CVCL_U911 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2805574-fdd3-40d5-bf01-ed5e4c32498f" - "SK-MEL-217": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2805574-fdd3-40d5-bf01-ed5e4c32498f + SK-MEL-217: meaning: rrid:CVCL_6111 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f4ac84fa-aadd-4a36-9aca-d1bc1e7a4c3e" - "SK-MEL-22": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f4ac84fa-aadd-4a36-9aca-d1bc1e7a4c3e + SK-MEL-22: meaning: rrid:CVCL_6026 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d53de27-93dd-4421-8612-2e3402106ee7" - "SK-MEL-222": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d53de27-93dd-4421-8612-2e3402106ee7 + SK-MEL-222: meaning: rrid:CVCL_6112 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46b0bf61-f688-43b7-97f6-29f3462b9313" - "SK-MEL-227": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46b0bf61-f688-43b7-97f6-29f3462b9313 + SK-MEL-227: meaning: rrid:CVCL_6113 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=210a3450-b6ff-4a15-b6b7-415d96246d1b" - "SK-MEL-228": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=210a3450-b6ff-4a15-b6b7-415d96246d1b + SK-MEL-228: meaning: rrid:CVCL_6114 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de2d02b5-5406-488f-bd57-03efcec737a9" - "SK-MEL-229": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de2d02b5-5406-488f-bd57-03efcec737a9 + SK-MEL-229: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6115 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05280043-5ac8-4427-9e19-f53c8efd260e" - "SK-MEL-23": - description: "Very highly pigmented." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05280043-5ac8-4427-9e19-f53c8efd260e + SK-MEL-23: + description: Very highly pigmented. meaning: rrid:CVCL_6027 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d6345dc-0415-4afe-965d-683c2f7fb6f3" - "SK-MEL-230": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d6345dc-0415-4afe-965d-683c2f7fb6f3 + SK-MEL-230: meaning: rrid:CVCL_6116 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=318b6745-af78-435e-9bd2-83fa22cf8c7b" - "SK-MEL-232": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=318b6745-af78-435e-9bd2-83fa22cf8c7b + SK-MEL-232: meaning: rrid:CVCL_6117 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a689488c-6aa3-4c3e-ab74-a58348944338" - "SK-MEL-233": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a689488c-6aa3-4c3e-ab74-a58348944338 + SK-MEL-233: meaning: rrid:CVCL_6118 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f927ed06-7d0e-43af-9031-dbedfc2c42d3" - "SK-MEL-234": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f927ed06-7d0e-43af-9031-dbedfc2c42d3 + SK-MEL-234: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6119 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7935406-82be-4ed6-82fe-0f387439cd4f" - "SK-MEL-237": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7935406-82be-4ed6-82fe-0f387439cd4f + SK-MEL-237: meaning: rrid:CVCL_6120 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efd49881-3065-4fff-a296-8dc1ea2f63b7" - "SK-MEL-238": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efd49881-3065-4fff-a296-8dc1ea2f63b7 + SK-MEL-238: meaning: rrid:CVCL_6121 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24f0992a-00ed-4a1f-b8f5-72e42cb8556d" - "SK-MEL-239": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24f0992a-00ed-4a1f-b8f5-72e42cb8556d + SK-MEL-239: meaning: rrid:CVCL_6122 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0128a62c-13f8-485e-802d-c4c3e1ef7905" - "SK-MEL-243": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0128a62c-13f8-485e-802d-c4c3e1ef7905 + SK-MEL-243: meaning: rrid:CVCL_6123 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4386a81c-a396-4600-a972-2b993cb9af0e" - "SK-MEL-244": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4386a81c-a396-4600-a972-2b993cb9af0e + SK-MEL-244: meaning: rrid:CVCL_6124 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=363d82b8-97ac-429a-b9d6-e195fb764e5c" - "SK-MEL-246": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=363d82b8-97ac-429a-b9d6-e195fb764e5c + SK-MEL-246: meaning: rrid:CVCL_6126 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4adf5880-df01-4b08-aed3-11366ca77f42" - "SK-MEL-252": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4adf5880-df01-4b08-aed3-11366ca77f42 + SK-MEL-252: meaning: rrid:CVCL_6127 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b1e67f2-410d-4a22-822d-c812003f6312" - "SK-MEL-256": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b1e67f2-410d-4a22-822d-c812003f6312 + SK-MEL-256: meaning: rrid:CVCL_6128 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31d0179a-4cd5-4454-a035-ef02f0ef284b" - "SK-MEL-264": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31d0179a-4cd5-4454-a035-ef02f0ef284b + SK-MEL-264: meaning: rrid:CVCL_6131 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ff17bb4d-4cb0-4366-8d6b-e59a7ad73837" - "SK-MEL-265": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ff17bb4d-4cb0-4366-8d6b-e59a7ad73837 + SK-MEL-265: meaning: rrid:CVCL_6132 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c7aa452-e44e-48b4-b57e-f0f11493c389" - "SK-MEL-266": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c7aa452-e44e-48b4-b57e-f0f11493c389 + SK-MEL-266: meaning: rrid:CVCL_6133 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffc1bc88-d5ec-4b2f-a36b-6052f9d736b7" - "SK-MEL-267": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffc1bc88-d5ec-4b2f-a36b-6052f9d736b7 + SK-MEL-267: meaning: rrid:CVCL_6134 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58864ae6-c1da-409e-a473-afbe769e35d0" - "SK-MEL-268": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58864ae6-c1da-409e-a473-afbe769e35d0 + SK-MEL-268: meaning: rrid:CVCL_6135 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a012aa8a-d3ab-4f4b-86dc-61c137f3b6b7" - "SK-MEL-269": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a012aa8a-d3ab-4f4b-86dc-61c137f3b6b7 + SK-MEL-269: meaning: rrid:CVCL_6136 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3edcb81d-31b5-4366-b5ad-69ec792df1c5" - "SK-MEL-27": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3edcb81d-31b5-4366-b5ad-69ec792df1c5 + SK-MEL-27: meaning: rrid:CVCL_6030 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e30707fe-357d-4aa8-92e9-8f2db981ef78" - "SK-MEL-271": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e30707fe-357d-4aa8-92e9-8f2db981ef78 + SK-MEL-271: meaning: rrid:CVCL_6137 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3b2a72b-66a5-4fcd-9200-4442c5c51a69" - "SK-MEL-272": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3b2a72b-66a5-4fcd-9200-4442c5c51a69 + SK-MEL-272: meaning: rrid:CVCL_6138 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4af69cf3-041f-46d0-8b20-cd5170ce42a7" - "SK-MEL-275": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4af69cf3-041f-46d0-8b20-cd5170ce42a7 + SK-MEL-275: meaning: rrid:CVCL_6139 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3571655-7dfb-4364-9d61-aebe2ae4039e" - "SK-MEL-276": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3571655-7dfb-4364-9d61-aebe2ae4039e + SK-MEL-276: meaning: rrid:CVCL_6140 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7c386a0-ee01-4ad2-9772-1c29715e26a3" - "SK-MEL-279": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7c386a0-ee01-4ad2-9772-1c29715e26a3 + SK-MEL-279: meaning: rrid:CVCL_6141 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5176605-b22b-45d6-b636-2be6faff0a13" - "SK-MEL-282": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5176605-b22b-45d6-b636-2be6faff0a13 + SK-MEL-282: meaning: rrid:CVCL_6143 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c81c271-14ab-4f29-b006-b2a71dce3009" - "SK-MEL-283": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c81c271-14ab-4f29-b006-b2a71dce3009 + SK-MEL-283: meaning: rrid:CVCL_6144 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=533ec9c8-8391-4979-9b39-e65cef5f9423" - "SK-MEL-284": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=533ec9c8-8391-4979-9b39-e65cef5f9423 + SK-MEL-284: meaning: rrid:CVCL_6145 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06aaab7a-7e1e-4ad0-b4c2-14245c60a927" - "SK-MEL-285": - description: "Mutation of KRAS, p.Gly12Cys (c.34G>T), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06aaab7a-7e1e-4ad0-b4c2-14245c60a927 + SK-MEL-285: + description: Mutation of KRAS, p.Gly12Cys (c.34G>T), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_6146 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=62654a64-d223-4d52-81e1-6869e071bc52" - "SK-MEL-301": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=62654a64-d223-4d52-81e1-6869e071bc52 + SK-MEL-301: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6147 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22c9daa2-d3bb-4e9d-b615-45fdd7506ae5" - "SK-MEL-304": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22c9daa2-d3bb-4e9d-b615-45fdd7506ae5 + SK-MEL-304: meaning: rrid:CVCL_6148 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b24851b4-c7b9-4265-b3dd-8cdd6ff1df6b" - "SK-MEL-306": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b24851b4-c7b9-4265-b3dd-8cdd6ff1df6b + SK-MEL-306: meaning: rrid:CVCL_6149 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c89cb4de-6160-452d-b8f9-054250e25207" - "SK-MEL-307": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c89cb4de-6160-452d-b8f9-054250e25207 + SK-MEL-307: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6150 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6c7e09f2-b4a4-4e21-a346-8d46c7815a25" - "SK-MEL-309B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6c7e09f2-b4a4-4e21-a346-8d46c7815a25 + SK-MEL-309B: meaning: rrid:CVCL_U912 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64f2ff80-3b84-4d42-985a-c7290ffb1ed3" - "SK-MEL-313": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64f2ff80-3b84-4d42-985a-c7290ffb1ed3 + SK-MEL-313: meaning: rrid:CVCL_1T59 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ebc58516-eb4c-4b8a-ac75-1ad3cc9ec258" - "SK-MEL-315-02": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ebc58516-eb4c-4b8a-ac75-1ad3cc9ec258 + SK-MEL-315-02: meaning: rrid:CVCL_E090 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b05001f1-b471-4d98-925b-521c4cbaf31d" - "SK-MEL-315-05": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b05001f1-b471-4d98-925b-521c4cbaf31d + SK-MEL-315-05: meaning: rrid:CVCL_E092 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9906bf3-21a5-4cef-9119-02b25b4a556f" - "SK-MEL-316": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9906bf3-21a5-4cef-9119-02b25b4a556f + SK-MEL-316: meaning: rrid:CVCL_6151 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=231c785d-ad45-4395-b7b9-64c734a79fd1" - "SK-MEL-318": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=231c785d-ad45-4395-b7b9-64c734a79fd1 + SK-MEL-318: meaning: rrid:CVCL_1T60 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05799982-53b2-4872-990d-9d79fdfcae38" - "SK-MEL-32": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05799982-53b2-4872-990d-9d79fdfcae38 + SK-MEL-32: meaning: rrid:CVCL_6032 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423ba382-0958-4015-a4f3-c01f29442df1" - "SK-MEL-321A": - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423ba382-0958-4015-a4f3-c01f29442df1 + SK-MEL-321A: + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_D771 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=11b6440f-fe1b-49be-835e-e3d063daba0e" - "SK-MEL-321B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=11b6440f-fe1b-49be-835e-e3d063daba0e + SK-MEL-321B: meaning: rrid:CVCL_E089 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=145c4d7f-81de-436c-801b-15cc2298895d" - "SK-MEL-323": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=145c4d7f-81de-436c-801b-15cc2298895d + SK-MEL-323: meaning: rrid:CVCL_6152 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5133ef-e87d-4026-a9b5-56ece87fde75" - "SK-MEL-325": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5133ef-e87d-4026-a9b5-56ece87fde75 + SK-MEL-325: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6153 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5cd8c18c-d03e-4129-913a-ab50484aa8ef" - "SK-MEL-326": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5cd8c18c-d03e-4129-913a-ab50484aa8ef + SK-MEL-326: meaning: rrid:CVCL_6154 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84aa6e1a-1d68-4923-beea-af84d7593a3e" - "SK-MEL-330": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84aa6e1a-1d68-4923-beea-af84d7593a3e + SK-MEL-330: meaning: rrid:CVCL_6155 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6aef573-0840-4920-b66a-0b361a22d92b" - "SK-MEL-332": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6aef573-0840-4920-b66a-0b361a22d92b + SK-MEL-332: meaning: rrid:CVCL_1T61 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a01e27d8-a50e-49c1-9a5d-5202460b94c2" - "SK-MEL-334": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a01e27d8-a50e-49c1-9a5d-5202460b94c2 + SK-MEL-334: meaning: rrid:CVCL_6156 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a065ee27-ac39-4fe2-82a2-8c92011f6b23" - "SK-MEL-339": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a065ee27-ac39-4fe2-82a2-8c92011f6b23 + SK-MEL-339: meaning: rrid:CVCL_6157 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b58976e-5983-411b-b193-75a16c63dfb9" - "SK-MEL-346": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b58976e-5983-411b-b193-75a16c63dfb9 + SK-MEL-346: meaning: rrid:CVCL_6159 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e465de74-8162-4b07-a5b9-2004fee28873" - "SK-MEL-35": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e465de74-8162-4b07-a5b9-2004fee28873 + SK-MEL-35: meaning: rrid:CVCL_6034 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24a85352-2025-4ba8-a8e4-9db6150c35ea" - "SK-MEL-351": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24a85352-2025-4ba8-a8e4-9db6150c35ea + SK-MEL-351: meaning: rrid:CVCL_6160 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce3b913-11dc-4827-8cd8-46b4fae21993" - "SK-MEL-359": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce3b913-11dc-4827-8cd8-46b4fae21993 + SK-MEL-359: meaning: rrid:CVCL_6161 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce242fc6-c98c-47fb-ab26-876ad418a8dc" - "SK-MEL-36": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce242fc6-c98c-47fb-ab26-876ad418a8dc + SK-MEL-36: meaning: rrid:CVCL_6035 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20fd4d84-bcf4-4016-84e6-904c8ab5d931" - "SK-MEL-364": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20fd4d84-bcf4-4016-84e6-904c8ab5d931 + SK-MEL-364: meaning: rrid:CVCL_6162 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86d7407c-c680-4866-a5c2-bc77e0488c6f" - "SK-MEL-366": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86d7407c-c680-4866-a5c2-bc77e0488c6f + SK-MEL-366: meaning: rrid:CVCL_6163 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46ea3bf7-34ca-48ab-8e55-e2eb1221c741" - "SK-MEL-367": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46ea3bf7-34ca-48ab-8e55-e2eb1221c741 + SK-MEL-367: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6164 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13938786-687b-4476-845f-04a0533aac60" - "SK-MEL-369": - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13938786-687b-4476-845f-04a0533aac60 + SK-MEL-369: + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6165 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=153a917d-42f2-4fa3-af4a-fa2d9aeea185" - "SK-MEL-380": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=153a917d-42f2-4fa3-af4a-fa2d9aeea185 + SK-MEL-380: meaning: rrid:CVCL_6166 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49c46106-2a7b-420f-ab36-3501ee7aede4" - "SK-MEL-381": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49c46106-2a7b-420f-ab36-3501ee7aede4 + SK-MEL-381: meaning: rrid:CVCL_6167 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee3cbd77-c4f4-46e3-b4c3-0bf945215117" - "SK-MEL-39": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee3cbd77-c4f4-46e3-b4c3-0bf945215117 + SK-MEL-39: meaning: rrid:CVCL_6036 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615c7563-d62b-4d4e-9852-6ba6ee5e1bb2" - "SK-MEL-390": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615c7563-d62b-4d4e-9852-6ba6ee5e1bb2 + SK-MEL-390: meaning: rrid:CVCL_6168 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1829be6d-fdc2-44eb-a1d1-32678faeb6c7" - "SK-MEL-391": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1829be6d-fdc2-44eb-a1d1-32678faeb6c7 + SK-MEL-391: meaning: rrid:CVCL_1T62 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86212d03-fe40-45e2-8fbf-587cd052b194" - "SK-MEL-393": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86212d03-fe40-45e2-8fbf-587cd052b194 + SK-MEL-393: meaning: rrid:CVCL_1T63 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9e7f25d9-7b2b-4272-9c80-dfaf030f0b36" - "SK-MEL-394": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9e7f25d9-7b2b-4272-9c80-dfaf030f0b36 + SK-MEL-394: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_1T64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3fa847e6-2be0-4b0d-bdab-630aaf9a10d4" - "SK-MEL-398": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3fa847e6-2be0-4b0d-bdab-630aaf9a10d4 + SK-MEL-398: meaning: rrid:CVCL_1T65 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a4ec3ce-a757-43ad-9c54-0999f94c4a10" - "SK-MEL-40": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a4ec3ce-a757-43ad-9c54-0999f94c4a10 + SK-MEL-40: meaning: rrid:CVCL_6037 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a997c565-7bda-4a81-a7cf-800d1612598e" - "SK-MEL-400": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a997c565-7bda-4a81-a7cf-800d1612598e + SK-MEL-400: meaning: rrid:CVCL_1T66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f4941d-ed79-41f1-9a2a-a494baed6d7b" - "SK-MEL-406": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f4941d-ed79-41f1-9a2a-a494baed6d7b + SK-MEL-406: meaning: rrid:CVCL_1T67 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=935f7b60-4c34-4fc9-a877-ec901f25f162" - "SK-MEL-408": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=935f7b60-4c34-4fc9-a877-ec901f25f162 + SK-MEL-408: meaning: rrid:CVCL_1T68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9a797dc-91ba-4592-bd06-967f5b38124d" - "SK-MEL-41": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9a797dc-91ba-4592-bd06-967f5b38124d + SK-MEL-41: meaning: rrid:CVCL_6038 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae3724e-ba3b-4787-b81e-d62d434a3ac9" - "SK-MEL-410": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae3724e-ba3b-4787-b81e-d62d434a3ac9 + SK-MEL-410: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_1T69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5f60fa1a-e9a7-4e49-a760-d2906ba17851" - "SK-MEL-411": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5f60fa1a-e9a7-4e49-a760-d2906ba17851 + SK-MEL-411: meaning: rrid:CVCL_1T70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cd4f5e0-e110-40ce-98c9-422fda40866e" - "SK-MEL-412Parotid": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cd4f5e0-e110-40ce-98c9-422fda40866e + SK-MEL-412Parotid: meaning: rrid:CVCL_1T71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=159262e3-0f60-4af6-95ff-a3696aa6db9e" - "SK-MEL-413-2": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=159262e3-0f60-4af6-95ff-a3696aa6db9e + SK-MEL-413-2: meaning: rrid:CVCL_1T72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=413969a1-e4c2-4a17-84de-5925d1209ed6" - "SK-MEL-423A": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=413969a1-e4c2-4a17-84de-5925d1209ed6 + SK-MEL-423A: meaning: rrid:CVCL_1T73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ba04cec-c260-462c-b8ce-75536ba04307" - "SK-MEL-423B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ba04cec-c260-462c-b8ce-75536ba04307 + SK-MEL-423B: meaning: rrid:CVCL_1T74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6954af4e-0907-460b-ace8-6f807dc897ea" - "SK-MEL-426": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6954af4e-0907-460b-ace8-6f807dc897ea + SK-MEL-426: meaning: rrid:CVCL_1T75 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20deb6a8-c59e-4f29-8ee8-cd9828191916" - "SK-MEL-427": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20deb6a8-c59e-4f29-8ee8-cd9828191916 + SK-MEL-427: meaning: rrid:CVCL_1T76 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13a298c0-38d6-4945-9afb-a7c3bb11509d" - "SK-MEL-428": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13a298c0-38d6-4945-9afb-a7c3bb11509d + SK-MEL-428: meaning: rrid:CVCL_1T77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d34fb6f1-ec5c-440e-97e9-276088635d67" - "SK-MEL-430": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d34fb6f1-ec5c-440e-97e9-276088635d67 + SK-MEL-430: meaning: rrid:CVCL_1T78 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=17aba291-d856-4625-aad0-077514b14d40" - "SK-MEL-431": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=17aba291-d856-4625-aad0-077514b14d40 + SK-MEL-431: meaning: rrid:CVCL_1T79 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f26dd6bb-0195-4571-98e2-23ec963c86ec" - "SK-MEL-432": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f26dd6bb-0195-4571-98e2-23ec963c86ec + SK-MEL-432: meaning: rrid:CVCL_1T80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913629f6-cace-496b-acb8-03c97e4ace11" - "SK-MEL-435": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913629f6-cace-496b-acb8-03c97e4ace11 + SK-MEL-435: meaning: rrid:CVCL_1T81 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e528ff6d-23e4-487b-9338-839d2c564a11" - "SK-MEL-439": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e528ff6d-23e4-487b-9338-839d2c564a11 + SK-MEL-439: meaning: rrid:CVCL_1T82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd531418-d7a3-456f-8473-1e9fd37ed3a5" - "SK-MEL-441": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd531418-d7a3-456f-8473-1e9fd37ed3a5 + SK-MEL-441: meaning: rrid:CVCL_1T83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4b5d552-0eea-4ff6-b127-6d9a691b5600" - "SK-MEL-444": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4b5d552-0eea-4ff6-b127-6d9a691b5600 + SK-MEL-444: meaning: rrid:CVCL_1T84 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13274e2e-62c6-49ec-92b5-78cafa4cfc73" - "SK-MEL-445": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13274e2e-62c6-49ec-92b5-78cafa4cfc73 + SK-MEL-445: meaning: rrid:CVCL_1T85 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=141f4221-e03d-4b75-a3da-ff8efb3aed02" - "SK-MEL-446": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=141f4221-e03d-4b75-a3da-ff8efb3aed02 + SK-MEL-446: meaning: rrid:CVCL_1T86 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41aea55a-717a-4460-8593-8b55e90937e6" - "SK-MEL-447": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41aea55a-717a-4460-8593-8b55e90937e6 + SK-MEL-447: meaning: rrid:CVCL_1T87 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878e80a7-4f50-4a23-a1e6-155d988962a5" - "SK-MEL-451": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878e80a7-4f50-4a23-a1e6-155d988962a5 + SK-MEL-451: meaning: rrid:CVCL_1T88 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20eba743-3053-4e3c-97fc-10a53023430b" - "SK-MEL-452": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20eba743-3053-4e3c-97fc-10a53023430b + SK-MEL-452: meaning: rrid:CVCL_1T89 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=042e2889-f4e3-4a3a-85d3-cfa860369bff" - "SK-MEL-455": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=042e2889-f4e3-4a3a-85d3-cfa860369bff + SK-MEL-455: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_1T90 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d77460a-3139-4299-a912-04a4b479ab44" - "SK-MEL-457": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d77460a-3139-4299-a912-04a4b479ab44 + SK-MEL-457: meaning: rrid:CVCL_1T91 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc15a768-cae1-4dc4-ae2e-d861db250ff9" - "SK-MEL-459": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc15a768-cae1-4dc4-ae2e-d861db250ff9 + SK-MEL-459: meaning: rrid:CVCL_1T92 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7cae97f-787c-49aa-9e78-a487e3e3547b" - "SK-MEL-462": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7cae97f-787c-49aa-9e78-a487e3e3547b + SK-MEL-462: meaning: rrid:CVCL_1T93 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3b36f15b-02d6-47c8-987a-09ccbc9b6e35" - "SK-MEL-464A": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3b36f15b-02d6-47c8-987a-09ccbc9b6e35 + SK-MEL-464A: meaning: rrid:CVCL_1T94 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0e8f539b-8704-47c8-a4c4-7402602d0445" - "SK-MEL-464B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0e8f539b-8704-47c8-a4c4-7402602d0445 + SK-MEL-464B: meaning: rrid:CVCL_1T95 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7440661f-af81-486a-9687-cf6a72d6fd82" - "SK-MEL-479": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7440661f-af81-486a-9687-cf6a72d6fd82 + SK-MEL-479: meaning: rrid:CVCL_1T96 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9612b172-8d91-4524-aa18-7cbe903c7f1b" - "SK-MEL-481": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9612b172-8d91-4524-aa18-7cbe903c7f1b + SK-MEL-481: meaning: rrid:CVCL_1T97 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed77fdc9-b80b-4817-8f86-a01fa5b141cc" - "SK-MEL-483": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed77fdc9-b80b-4817-8f86-a01fa5b141cc + SK-MEL-483: meaning: rrid:CVCL_1T98 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8f27d0-385b-4dc1-82e8-60a456eff3b2" - "SK-MEL-495": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8f27d0-385b-4dc1-82e8-60a456eff3b2 + SK-MEL-495: meaning: rrid:CVCL_1T99 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fa9c1a3-1945-45b1-a9f1-9edb3afd569c" - "SK-MEL-498": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fa9c1a3-1945-45b1-a9f1-9edb3afd569c + SK-MEL-498: meaning: rrid:CVCL_1U00 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce4f80b9-50a2-400c-bd0f-1a1df82931b7" - "SK-MEL-506": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce4f80b9-50a2-400c-bd0f-1a1df82931b7 + SK-MEL-506: meaning: rrid:CVCL_1U01 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=78d23c04-59b6-4532-910a-40cbf8b4d702" - "SK-MEL-507": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=78d23c04-59b6-4532-910a-40cbf8b4d702 + SK-MEL-507: meaning: rrid:CVCL_1U02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee56490c-9c27-4952-b001-230e572cb108" - "SK-MEL-509": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee56490c-9c27-4952-b001-230e572cb108 + SK-MEL-509: meaning: rrid:CVCL_1U03 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1e0094a-ce3a-4505-8d4d-426adf6ec84e" - "SK-MEL-513": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1e0094a-ce3a-4505-8d4d-426adf6ec84e + SK-MEL-513: meaning: rrid:CVCL_1U04 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=29590580-da13-41b2-a8d3-bd1a2b198f28" - "SK-MEL-524": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=29590580-da13-41b2-a8d3-bd1a2b198f28 + SK-MEL-524: meaning: rrid:CVCL_1U05 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1eeb831e-3fd4-4d88-9384-717b7dcc20d8" - "SK-MEL-529": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1eeb831e-3fd4-4d88-9384-717b7dcc20d8 + SK-MEL-529: meaning: rrid:CVCL_1U06 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ccd7e8d-f5b2-4e2b-8f21-8b982d8921d6" - "SK-MEL-534": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ccd7e8d-f5b2-4e2b-8f21-8b982d8921d6 + SK-MEL-534: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_1U07 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7515b60c-dc11-4786-b3aa-fd7a8f5397f1" - "SK-MEL-538": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7515b60c-dc11-4786-b3aa-fd7a8f5397f1 + SK-MEL-538: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830). meaning: rrid:CVCL_1U08 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e2a83d29-7938-4a12-ae21-75b4dbbff7ac" - "SK-MEL-64": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e2a83d29-7938-4a12-ae21-75b4dbbff7ac + SK-MEL-64: meaning: rrid:CVCL_6048 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=053cef50-1dee-46f8-b4a9-2881742ff06d" - "SK-MEL-7": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=053cef50-1dee-46f8-b4a9-2881742ff06d + SK-MEL-7: meaning: rrid:CVCL_D854 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3be7fe60-bbb4-497b-9cd1-8b5c7005cb92" - "SK-MEL-73": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3be7fe60-bbb4-497b-9cd1-8b5c7005cb92 + SK-MEL-73: meaning: rrid:CVCL_6053 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a342ec-bfa3-490e-b8b2-51141b588def" - "SK-MEL-75": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a342ec-bfa3-490e-b8b2-51141b588def + SK-MEL-75: meaning: rrid:CVCL_6054 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46c046c5-20ac-4a51-a73a-758f0a881b2a" - "SK-MEL-90": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46c046c5-20ac-4a51-a73a-758f0a881b2a + SK-MEL-90: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6227 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f3abe8b-5048-4e2f-beae-63a437218761" - "SK-N-AS": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f3abe8b-5048-4e2f-beae-63a437218761 + SK-N-AS: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap). meaning: rrid:CVCL_1700 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cebfdef3-2323-48d9-bfbb-aa704338eabe" - "SK-N-FI": - description: "Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cebfdef3-2323-48d9-bfbb-aa704338eabe + SK-N-FI: + description: Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465). meaning: rrid:CVCL_1702 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c53f612-f254-487d-a545-186fd4e2b856" - "SK-N-SH": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c53f612-f254-487d-a545-186fd4e2b856 + SK-N-SH: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (Cosmic-CLP, DepMap). meaning: rrid:CVCL_0531 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb1b960d-bfd7-48d2-b467-c7faf52b4b3a" - "SMBCi003-A": - description: "Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb1b960d-bfd7-48d2-b467-c7faf52b4b3a + SMBCi003-A: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297). meaning: rrid:CVCL_YC55 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25e3f6d6-c625-43fc-a1ed-c267bba685f1" - "SMBCi003-B": - description: "Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25e3f6d6-c625-43fc-a1ed-c267bba685f1 + SMBCi003-B: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297). meaning: rrid:CVCL_YC56 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0361ea84-13bb-4f90-8f24-bbd01a81801e" - "SMBCi003-C": - description: "Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (from autologous cell lines SMBCi003-A and SMBCi003-B)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0361ea84-13bb-4f90-8f24-bbd01a81801e + SMBCi003-C: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (from autologous cell lines SMBCi003-A and SMBCi003-B). meaning: rrid:CVCL_YC57 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08a0f6ee-700b-4df3-94cd-cc414214ca99" - "SNU-407": - description: "1 alleles of G12D mutation in KRAS gene, KRAS codon 12 GGT->GAT. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=10362137, Cosmic-CLP)." - meaning: rrid:CVCL_5058 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a05a7478-548d-4e6b-b7d0-17891a503e06" - "SNU-C2A": - description: "1 alleles of G12D mutation in KRAS gene. Established from a nude mouse xenograft. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap)." - meaning: rrid:CVCL_1709 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c51a1afa-d499-4630-8995-a61c9fd733b1" - "SOX10+ SLC": - description: "Human induced pluripotent stem cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3e07933-db64-48ea-bfa5-ed22a8647770" - "ST88-14": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_8916 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=202c110b-a5f1-49ab-acdc-e6e33a1c29bb" - "ST88-3": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08a0f6ee-700b-4df3-94cd-cc414214ca99 + ST88-3: meaning: rrid:CVCL_IU70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b368f84e-f38b-4ff0-9458-fe5d8b91122d" - "STR-I-437-NF1": - description: "From: INSERM, France." - meaning: rrid:CVCL_Y599 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01040031-60ba-4da5-96b0-d4a0a2f9131b" - "STR-I-441-NF1": - description: "From: INSERM, France." - meaning: rrid:CVCL_Y600 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1372bf73-291f-48f9-9207-81120a299675" - "STR-I-443-NF1": - description: "From: INSERM, France." - meaning: rrid:CVCL_Y601 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5352596f-7192-473c-85b3-2aeb0fbf8e48" - "STS-26T": - description: "Sporadic MPNST tumor cell line from a non-NF1 patient." - meaning: rrid:CVCL_8917 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9a7997c9-9399-47ed-b44b-5b717be89ba3" - "STSA-1": - description: "Mutation of NF1, p.Met877fs (c.2626dupT), Heterozygous (PubMed=31175136)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b368f84e-f38b-4ff0-9458-fe5d8b91122d + STSA-1: + description: Mutation of NF1, p.Met877fs (c.2626dupT), Heterozygous (PubMed=31175136). meaning: rrid:CVCL_D274 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=203f9103-dd83-4879-8a5c-9d8541ae2267" - SU.86.86: - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Hemizygous (PubMed=11115575)." - meaning: rrid:CVCL_3881 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=69abfb3f-7d1e-4433-b542-909b794dd72f" - SW1463: - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=28683746, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1718 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42a7d7eb-f6df-45b8-80fc-242650606a84" - SW1573: - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, ATCC, Cosmic-CLP)." - meaning: rrid:CVCL_1720 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b600b899-2a05-44bb-bc3a-3359a45fa2f9" - SW1990: - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1723 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d519727-94e9-4f9e-95d3-9227443c03fe" - SW403: - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0545 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed7ecfd-36d3-4573-8e07-210c6088c3a7" - SW480: - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=20570890, PubMed=24755471, PubMed=28683746, DepMap)." - meaning: rrid:CVCL_0546 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b79f24b-7362-4687-8c66-03bcb6a26ab3" - SW620: - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746)." - meaning: rrid:CVCL_0547 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cf15506-fb63-49a8-b36e-6a28a67b4c6d" - SW837: - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746)." - meaning: rrid:CVCL_1729 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8a15b9-b7b8-42b7-ae4e-ca3ae1ac0be7" - SW900: - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, Cosmic-CLP)." - meaning: rrid:CVCL_1731 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=880c525a-f1df-49df-afe5-61ad07304c6a" - "SZ-NF1": - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_YL57 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=33cdb482-618e-4489-87d9-3139cc7c6a49" - "SZ-NF2": - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_YL58 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc2045df-5ebf-4491-b5b1-88d65e59b228" - "SZ-NF4": - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_YL59 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09c988ab-765a-44ca-b2d7-1957b729208e" - "SZ-NF6": - description: "From: Shaare Zedek Medical Center, The Hebrew University, Jerusalem, Israel., Mutation of NF1, c.4269+1G>C, Unspecified zygosity (Direct author submission)" - meaning: rrid:CVCL_YY00 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7ae798-a355-4b78-b1c3-6c82e3f917a7" - "Schwann cell NF1 -/- (iPN97.4 #24)": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- (iPN97.4 #24)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=234515dd-7c28-4172-83c7-59dddfa22acb" - "Schwann cell NF1 -/- with R681X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R681X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=faf29a50-3168-4ccd-a484-f2a78a026af3" - "Schwann cell NF1 -/- with R816X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R816X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a3e5460-3d5b-45f9-995d-25bd49c06f34" - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with WT tagged mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3beebac1-95b0-4834-9008-19f7d268fc5b" - "ScienCell Schwann cells": - description: "[From ScienCell:] HSC from ScienCell Research Laboratories are isolated from human spinal nerve. (editorial note: these cells likely come from multiple donors)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b751b5d4-56e6-42a2-a2dc-289f90c6dd82" - T265: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_S805 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6419dd0d-1937-4ecf-bf01-876632ae0f54" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=203f9103-dd83-4879-8a5c-9d8541ae2267 T351: - description: "Mutation of NF1, p.Gln28Ter (c.82C>T), Homozygous (PubMed=30737244)." + description: Mutation of NF1, p.Gln28Ter (c.82C>T), Homozygous (PubMed=30737244). meaning: rrid:CVCL_M977 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a29e2129-bee7-4d37-b0b6-c933f6e4bf84" - "T3M-10": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap)." - meaning: rrid:CVCL_8067 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c2fbf5a-1c45-43f0-87bb-bb97ea9062f0" - T84: - description: "1 alleles of G13D mutation in KRAS gene. Established from a xenograft produced by subcutaneous injection of the tumor cells into BALB/c nude mice. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=20570890, PubMed=24755471, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0555 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=281f0309-ec7d-443a-850f-9327e36c9b9f" - "TM-31": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a29e2129-bee7-4d37-b0b6-c933f6e4bf84 + TM-31: meaning: rrid:CVCL_6735 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb9f27dd-53d0-44c2-a1e9-21a7bbd08fb1" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb9f27dd-53d0-44c2-a1e9-21a7bbd08fb1 TR14: meaning: rrid:CVCL_B474 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8ec4106-295f-4fa3-b744-40b6f9b68d38" - "U-87MG ATCC IDH1 p.R132H": - description: "Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8ec4106-295f-4fa3-b744-40b6f9b68d38 + U-87MG ATCC IDH1 p.R132H: + description: Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line). meaning: rrid:CVCL_UE09 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2eb64d9c-3481-455d-b2e4-b9d297ed6366" - "U-87MG ATCC IDH1 p.R132H-Luc2": - description: "Stably expresses firefly luciferase under the control of the human EF-1 alpha promoter. Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2eb64d9c-3481-455d-b2e4-b9d297ed6366 + U-87MG ATCC IDH1 p.R132H-Luc2: + description: Stably expresses firefly luciferase under the control of the human EF-1 alpha promoter. Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line). meaning: rrid:CVCL_UR35 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64615ea4-6879-49ff-8f10-18c6710cb33c" - "U87-NF1-419": - description: "Generated U87-NF1-419 to evaluate the role of circNF1-419 on cell cycle, apoptosis, proliferation, tumor growth and metabolic regulation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8eee8013-cc31-43a4-903e-a5db2201e5f0" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64615ea4-6879-49ff-8f10-18c6710cb33c UCD65: - description: "Established from a patient-derived xenograft. ER/PR-positive and ERBB2-negative. Mutation of NF1, p.Leu792fs*2 (c.2372dupT), Unspecified zygosity (PubMed=32576280)." + description: Established from a patient-derived xenograft. ER/PR-positive and ERBB2-negative. Mutation of NF1, p.Leu792fs*2 (c.2372dupT), Unspecified zygosity (PubMed=32576280). meaning: rrid:CVCL_ZV44 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=07d262bf-6db9-4825-a25b-b58322b02436" - "UHG-NP": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=07d262bf-6db9-4825-a25b-b58322b02436 + UHG-NP: meaning: rrid:CVCL_A436 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91cec0db-b483-4674-9636-e2fc4a91bf61" - "WT ES": - description: "[From GFF:] WT ES" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1097f821-56c3-4e51-bcd3-f84aef506e3a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91cec0db-b483-4674-9636-e2fc4a91bf61 WW165: meaning: rrid:CVCL_G321 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ef44c14-d0a5-4933-b433-88da4ec1e30c" - WZJ: - description: "From a surgically excised pNF specimen of a 12-year-old boy with NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb814003-cd22-430d-a3b7-e387ef8eac76" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ef44c14-d0a5-4933-b433-88da4ec1e30c XF: meaning: rrid:CVCL_6E64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2a2dca4-ebcc-4c8e-94c8-c867beaca9ab" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2a2dca4-ebcc-4c8e-94c8-c867beaca9ab XL110: meaning: rrid:CVCL_T702 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0ee4d8e-2435-4e4a-bcc7-051d93fe686a" - YAPC: - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1794 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f51cbf29-987e-4950-9b46-1a607d5413a1" - "YST-1": - description: "Schwannoma cell line, potentially mischaracterized in some cases as a sporadic MPNST cell line." - meaning: rrid:CVCL_5192 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=617cb183-3377-4473-8ad8-2f6472bce1fa" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0ee4d8e-2435-4e4a-bcc7-051d93fe686a YUAME: - description: "Mutation of HRAS, p.Gly13Arg (c.37G>C), Unspecified zygosity (PubMed=26214590)." + description: Mutation of HRAS, p.Gly13Arg (c.37G>C), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI13 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df7e5a09-048e-4281-9fbb-52d3ce6cfa15" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df7e5a09-048e-4281-9fbb-52d3ce6cfa15 YUAVEY: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K001 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f87dbfd5-c5ea-4a76-b226-f7282caf042f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f87dbfd5-c5ea-4a76-b226-f7282caf042f YUBEL: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J515 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5c24057-9be9-433d-bba7-c49ca49cdca6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5c24057-9be9-433d-bba7-c49ca49cdca6 YUBUNE: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J516 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a900c25-09ab-4a7b-b09c-04f7b72b3830" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a900c25-09ab-4a7b-b09c-04f7b72b3830 YUCAL: meaning: rrid:CVCL_J532 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1b65d6a-eb4a-4b19-8952-ce42b28b88ad" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1b65d6a-eb4a-4b19-8952-ce42b28b88ad YUCAS: - description: "Mutation of NF1, p.Ile679Aspfs*21 (c.2033dupC), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Ile679Aspfs*21 (c.2033dupC), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J065 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d21f9de9-7ceb-434d-b940-f2c9781fade9" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d21f9de9-7ceb-434d-b940-f2c9781fade9 YUCHER: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J517 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f00fc26-31a0-464f-94a5-63e49d2deb0d" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f00fc26-31a0-464f-94a5-63e49d2deb0d YUCHIME: - description: "Mutation of NF1, p.Lys1714Asn, Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Lys1714Asn, Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI14 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64b1f481-af8d-47b8-b72a-8efcc2551ac3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64b1f481-af8d-47b8-b72a-8efcc2551ac3 YUCHUFA: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K003 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=730fff1a-f05a-4ef3-9166-31066a998e01" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=730fff1a-f05a-4ef3-9166-31066a998e01 YUCINJ: meaning: rrid:CVCL_K004 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=74c1381d-28e3-483c-8549-2effe3e005c2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=74c1381d-28e3-483c-8549-2effe3e005c2 YUCLAT: - description: "Mutation of NF1, p.Ser2496Phe (c.7487C>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Ser2496Phe (c.7487C>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J518 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a58ef8da-482f-4939-88b0-f48fc791ceb7" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a58ef8da-482f-4939-88b0-f48fc791ceb7 YUCOT: meaning: rrid:CVCL_J066 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=385bf0ee-9d93-4d01-ab72-767e2f07b5c5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=385bf0ee-9d93-4d01-ab72-767e2f07b5c5 YUCYLO: meaning: rrid:CVCL_EI15 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=270fe506-9979-4df5-864a-2f0267e6e0f3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=270fe506-9979-4df5-864a-2f0267e6e0f3 YUDATE: meaning: rrid:CVCL_K006 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe88fad9-bf75-4bd8-8cc3-c05fec76fc5e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe88fad9-bf75-4bd8-8cc3-c05fec76fc5e YUDEDE: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Heterozygous (PubMed=20149136, PubMed=26214590). meaning: rrid:CVCL_G322 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cef36cc-a45e-4af4-aaff-d929b7f90544" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cef36cc-a45e-4af4-aaff-d929b7f90544 YUDEW: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J519 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe05e40-087b-436a-a222-18e7b4061643" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe05e40-087b-436a-a222-18e7b4061643 YUDOSO: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=20149136, PubMed=26214590). meaning: rrid:CVCL_G323 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ad85e3f-886e-4e2c-ae51-f07be69d74a3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ad85e3f-886e-4e2c-ae51-f07be69d74a3 YUDUTY: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K007 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72a07165-cd79-4a3d-ae4f-9b79578ea974" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72a07165-cd79-4a3d-ae4f-9b79578ea974 YUFIC: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Heterozygous (PubMed=20149136, PubMed=26214590). meaning: rrid:CVCL_G324 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abd508df-8730-4ae9-abae-f544616c2ee5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abd508df-8730-4ae9-abae-f544616c2ee5 YUGANK: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K009 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ab474b0-8f19-407d-a85e-3f12dff66075" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ab474b0-8f19-407d-a85e-3f12dff66075 YUGASP: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J520 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c96e7008-ebaf-4a4b-9d11-acc1cd9cf05b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c96e7008-ebaf-4a4b-9d11-acc1cd9cf05b YUGATOR: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI17 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ea076a0-c21c-4bbc-b379-13b30c11a5fd" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ea076a0-c21c-4bbc-b379-13b30c11a5fd YUGEN8: meaning: rrid:CVCL_A744 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01611630-bca0-4923-9934-f8c2690b9c7e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01611630-bca0-4923-9934-f8c2690b9c7e YUGOE: - description: "Mutation of NRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J067 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2fcbabd-a6f6-439b-87c0-c1c6dde92128" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2fcbabd-a6f6-439b-87c0-c1c6dde92128 YUHEF: - description: "Mutation of NF1, p.Gln853Ter (c.2557C>T), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Lys2552Thrfs*2, Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Gln853Ter (c.2557C>T), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Lys2552Thrfs*2, Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_G326 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8cc9b6b-d1fc-4e77-8f10-3ca5737bcd5c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8cc9b6b-d1fc-4e77-8f10-3ca5737bcd5c YUKADI: meaning: rrid:CVCL_K011 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8667847-6e03-4db3-ae9a-53bccac0147b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8667847-6e03-4db3-ae9a-53bccac0147b YUKIM: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_G328 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=39e7b045-3bca-47cf-9cd5-e070beda179c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=39e7b045-3bca-47cf-9cd5-e070beda179c YUKOLI: meaning: rrid:CVCL_G329 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e124f7a-e2f4-4e63-965e-f4385c1f7f17" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e124f7a-e2f4-4e63-965e-f4385c1f7f17 YUKSI: meaning: rrid:CVCL_J068 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd13dcdf-bc8b-4d1f-8a53-8409cc3eb7a2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd13dcdf-bc8b-4d1f-8a53-8409cc3eb7a2 YULAPE: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K013 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=924186ef-bb8f-46aa-9ef2-bac3a04bdf6b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=924186ef-bb8f-46aa-9ef2-bac3a04bdf6b YULAXER: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K014 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=97c08096-3364-4d31-881c-c9d40e19daa5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=97c08096-3364-4d31-881c-c9d40e19daa5 YULOCUS: - description: "Mutation of KRAS, p.Gly12Ile (c.34_35GG>AT) (c.34_35delinsAT), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Gln2239Ter (c.6715C>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of KRAS, p.Gly12Ile (c.34_35GG>AT) (c.34_35delinsAT), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Gln2239Ter (c.6715C>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI19 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0bea258-655e-4a9b-a213-48aa86ac42d6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0bea258-655e-4a9b-a213-48aa86ac42d6 YULOMA: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K015 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0c66ec1-78dc-4dec-9c3a-f2684b836cee" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0c66ec1-78dc-4dec-9c3a-f2684b836cee YULONE: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J523 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9e160e6-76ae-4ae8-8c98-2ea114f6d769" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9e160e6-76ae-4ae8-8c98-2ea114f6d769 YULOVY: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Heterozygous (PubMed=20149136, PubMed=26214590). meaning: rrid:CVCL_G330 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=384a1121-6aa6-4d4b-8aab-e4539e9d2f26" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=384a1121-6aa6-4d4b-8aab-e4539e9d2f26 YUMAC: meaning: rrid:CVCL_A745 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=696fac03-8787-4298-927c-3848d707f1bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=696fac03-8787-4298-927c-3848d707f1bb YUMINE: meaning: rrid:CVCL_K016 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8c85c7-6714-49ab-83a8-8b0d9338bc03" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8c85c7-6714-49ab-83a8-8b0d9338bc03 YUMOBER: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI20 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc4a3b69-b7ba-4395-883f-88ff0fc099c2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc4a3b69-b7ba-4395-883f-88ff0fc099c2 YUMUT: meaning: rrid:CVCL_G331 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe79218f-2f91-47f6-a285-c265afbc1a00" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe79218f-2f91-47f6-a285-c265afbc1a00 YUNACK: meaning: rrid:CVCL_EI21 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913f5cef-7da3-44f9-8015-458f6993ea08" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913f5cef-7da3-44f9-8015-458f6993ea08 YUNIBO: meaning: rrid:CVCL_J535 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4990cf1-b921-45f1-94f6-1b286efeb1bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4990cf1-b921-45f1-94f6-1b286efeb1bb YUPAC7: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI22 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffbad5d9-74c8-4a48-8476-8a1a254b63eb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffbad5d9-74c8-4a48-8476-8a1a254b63eb YUPEET: meaning: rrid:CVCL_K018 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98f2d2a8-f264-4949-8d77-6a5e895d3708" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98f2d2a8-f264-4949-8d77-6a5e895d3708 YUPLA: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J069 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47287b25-40be-4a08-bfa7-94da91b45c08" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47287b25-40be-4a08-bfa7-94da91b45c08 YUPOM: meaning: rrid:CVCL_EI23 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f383e78a-772f-466a-a33b-69ca2864093e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f383e78a-772f-466a-a33b-69ca2864093e YURDE: meaning: rrid:CVCL_K019 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0104b0cf-9664-4f95-854b-04f9146af2be" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0104b0cf-9664-4f95-854b-04f9146af2be YURED: - description: "Mutation of NF1, p.Leu972Pro (c.2915T>C), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Leu972Pro (c.2915T>C), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K020 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cfa26941-984f-4a81-8314-f35c4e13e8bd" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cfa26941-984f-4a81-8314-f35c4e13e8bd YURIF: meaning: rrid:CVCL_B485 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fdfb9ef-767c-4f61-aea2-1b9495f89478" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fdfb9ef-767c-4f61-aea2-1b9495f89478 YURKEN: - description: "Mutation of NF1, p.Pro228Ser (c.682C>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Pro228Ser (c.682C>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K021 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5fbbf3e3-b922-4a20-9720-b175c2260d14" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5fbbf3e3-b922-4a20-9720-b175c2260d14 YUROB: - description: "Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_B486 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4cef2d2-31aa-4cd8-90a2-25584fc0e1e0" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4cef2d2-31aa-4cd8-90a2-25584fc0e1e0 YUROL: meaning: rrid:CVCL_J070 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f4f972c-992a-4f71-80d7-b3ce3403e0f8" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f4f972c-992a-4f71-80d7-b3ce3403e0f8 YUSARI: meaning: rrid:CVCL_K022 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=baf37457-11ec-4540-8e2b-28e51a6804d7" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=baf37457-11ec-4540-8e2b-28e51a6804d7 YUSIK: meaning: rrid:CVCL_B487 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5631551-e263-4ed3-b2d6-8a31f6913e63" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5631551-e263-4ed3-b2d6-8a31f6913e63 YUSIPU: meaning: rrid:CVCL_EI16 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e50b8062-cdc9-406d-af28-187b4c50995e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e50b8062-cdc9-406d-af28-187b4c50995e YUSIT1: meaning: rrid:CVCL_A747 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21c31a9f-36c6-4e3e-a5d4-abac01667a79" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21c31a9f-36c6-4e3e-a5d4-abac01667a79 YUSIV: meaning: rrid:CVCL_G332 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db0bd299-eaf1-475d-81f9-15feb63fc6e3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db0bd299-eaf1-475d-81f9-15feb63fc6e3 YUSTE: meaning: rrid:CVCL_J527 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37657790-e578-4f21-9127-c6972206b407" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37657790-e578-4f21-9127-c6972206b407 YUSUBA: meaning: rrid:CVCL_K023 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5ed8a55-c03f-467a-9381-58e92ade9f74" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5ed8a55-c03f-467a-9381-58e92ade9f74 YUSWI: meaning: rrid:CVCL_K024 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=77b38c3b-775d-4452-8782-13dd5f069146" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=77b38c3b-775d-4452-8782-13dd5f069146 YUTER: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_K025 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4034cf5b-c84f-4b22-ae06-d60edc183621" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4034cf5b-c84f-4b22-ae06-d60edc183621 YUTICA: - description: "Mutation of NF1, p.Pro1667Leu (c.5000C>T), Unspecified zygosity (PubMed=26214590). Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Pro1667Leu (c.5000C>T), Unspecified zygosity (PubMed=26214590). Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_J071 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8ed167e-22b3-4ab1-a98f-65581c1bc8ab" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8ed167e-22b3-4ab1-a98f-65581c1bc8ab YUWAGE: meaning: rrid:CVCL_K026 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=592cf430-f5fd-4a97-936f-56de2bb5bc3b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=592cf430-f5fd-4a97-936f-56de2bb5bc3b YUWALI: meaning: rrid:CVCL_K027 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb1c24cb-9912-4b7d-89ca-b97399234671" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb1c24cb-9912-4b7d-89ca-b97399234671 YUWHIM: meaning: rrid:CVCL_K028 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf7ded95-9f27-4cac-9753-d89a9b157b94" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf7ded95-9f27-4cac-9753-d89a9b157b94 YUZAZ: meaning: rrid:CVCL_EI18 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84a6d041-7d20-4a92-8def-55e86ee45062" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84a6d041-7d20-4a92-8def-55e86ee45062 YUZEAL: meaning: rrid:CVCL_K029 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=23aa4d92-5bae-4bee-b506-3a8484f58a2a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=23aa4d92-5bae-4bee-b506-3a8484f58a2a YUZEST: meaning: rrid:CVCL_EI24 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2aaf2d-1dc7-4515-9475-ac07ae59152c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2aaf2d-1dc7-4515-9475-ac07ae59152c ZX2021H: - description: "Mutation of NF1, p.Cys2134Tyrfs*8 (c.6401_6402del) (p.L2133fs, c.6398_6399del), Unspecified zygosity (PubMed=35297208)." + description: Mutation of NF1, p.Cys2134Tyrfs*8 (c.6401_6402del) (p.L2133fs, c.6398_6399del), Unspecified zygosity (PubMed=35297208). meaning: rrid:CVCL_B6ZD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08c395bc-b13c-42fa-8b99-ba6864c65928" - "c.1149C > A NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ec8883f5-db93-4c66-9970-792b71b653ac" - "c.1185+1G > A NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3978a8ca-aad8-49f5-a513-70b5acd0f92e" - "c.3431-32_dupGT NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=831ba769-4809-4e31-9214-23bfb0377c19" - "c.5425C > T NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5dbc86-c52d-4713-8a03-ddf3ae42695f" - "c.6619C > T NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13be6b59-6b84-4d38-add9-3e87631bddf3" - cNF00.10a: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF00.10a)." - meaning: rrid:CVCL_B9UZ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad2e271b-55ac-44ae-b39d-f1a6d76e1dc3" - cNF04.9a: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF04.9a)." - meaning: rrid:CVCL_B9VB - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5b9e065-6855-4a11-bceb-681d8e82ae5e" - cNF97.2a: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2a)." - meaning: rrid:CVCL_B9V1 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d390b3f3-fea7-46d2-9bb7-dc72d59b2ccc" - cNF97.2b: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2b)." - meaning: rrid:CVCL_B9V2 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4987f0a-67ec-4f13-96f1-9443aac6e5ac" - cNF98.4c: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4c)." - meaning: rrid:CVCL_B9V5 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df513bb8-697a-4cac-ae6c-5aca6113ac24" - cNF98.4d: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4d)." - meaning: rrid:CVCL_B9V6 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=882101e0-1207-4323-a354-6d5a642e6ca3" - "hTERT NF1 ipNF00.6": - description: "Derived from a plexiform neurofibroma." - meaning: rrid:CVCL_UI76 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8f48ce7-438c-4564-a70b-020abc96d5fe" - "hTERT NF1 ipNF03.3": - description: "Derived from a plexiform neurofibroma." - meaning: rrid:CVCL_UI77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f21cb7db-ee85-48a7-8f41-e4603238bede" - "hTERT NF1 ipNF04.4": - description: "Derived from a plexiform neurofibroma." - meaning: rrid:CVCL_UI78 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fdc5f7a-ef8c-4193-a5c0-04577c3b134d" - "hTERT NF1 ipNF05.5": - description: "Derived from a plexiform neurofibroma growing on a hand." - meaning: rrid:CVCL_UI71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5502caf5-4cf1-418f-bf50-164cfa316b0f" - "hTERT NF1 ipNF05.5 (Mixed clones)": - description: "Derived from a plexiform neurofibroma growing on a hand." - meaning: rrid:CVCL_UI72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844b598c-0171-4972-91c3-27aa21b45d52" - "hTERT NF1 ipNF95.11b C": - description: "Derived from a plexiform neurofibroma growing on a brachial plexus." - meaning: rrid:CVCL_UI67 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be2333d6-6716-4d13-947d-41f4198497a4" - "hTERT NF1 ipNF95.11b C/T": - description: "Derived from a plexiform neurofibroma growing on a brachial plexus." - meaning: rrid:CVCL_UI68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ab60aae5-7860-4d1d-bb02-208e6631c78b" - "hTERT NF1 ipNF95.6": - description: "Derived from a plexiform neurofibroma growing on cranial nerve XII." - meaning: rrid:CVCL_UI70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b44361f2-9021-4920-901a-b1a1f9143f97" - "hTERT NF1 ipn06.2 A": - description: "Derived from a pleural plexiform neurofibroma." - meaning: rrid:CVCL_UI74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dedf9d2-614c-4cf9-8d18-aff8aa2dc0eb" - "hTERT NF1 ipnNF09.4": - description: "Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation." - meaning: rrid:CVCL_UI73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e0602ff-e3e6-438e-9fb7-c7abc1dd4304" - "hTERT NF1 ipnNF95.11c": - description: "Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation." - meaning: rrid:CVCL_UI69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c4c8b02-f12e-4a17-a408-38ae88dd841d" - "hTERT NF1 sipnNF95.12B": - description: "Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation." - meaning: rrid:CVCL_UI75 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98beda5b-9b28-4119-829a-2a0219d77af7" - "hTERT SC ipn97.4": - description: "Healthy Schwann cells." - meaning: rrid:CVCL_UI66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13ae2445-21e3-4b75-ae70-317a3d5ee40c" - "hTERT ipn02.3 2λ": - description: "Derived from peripheral sciatic nerve from a donor without neurofibromatosis. No detectable NF1 mutation." - meaning: rrid:CVCL_UI64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a507bfd-7d2b-4238-b79a-83fe985c2cea" - "hTERT ipn02.8": - description: "Derived from peripheral nerve from a donor without neurofibromatosis. No detectable NF1 mutation." - meaning: rrid:CVCL_UI65 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a8f5be4-aa22-48f2-9a76-9412010ecd45" - i28cNF: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (28NF)." - meaning: rrid:CVCL_B9VA - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e9ec3f3-5622-4f8f-a02c-34d8777c82b6" - "iPSC NF1 +/- BJFF.6 bkgd": - description: "[From GFF:] iPSC NF1 +/- BJFF.6 bkgd" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0c91627-fad6-4d60-bf74-67623374eff8" - "iPSC NF1 WT": - description: "[From GFF:] iPSC NF1 WT BJFF.6 bkgd" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4cf14492-2735-4e31-ab6a-75554b9ad298" - "iPSC Y489C; Exon 13 cryptic splice": - description: "[From GFF:] iPSC Y489C; Exon 13 cryptic splice, PGP1 cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad73cdb2-8add-48ff-b9f2-35a38132db84" - icNF00.10a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF00.10a)." - meaning: rrid:CVCL_B9V0 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ef2fd6f-9ba6-4e30-94fc-d4ffd61de6e6" - icNF04.9a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF04.9a)." - meaning: rrid:CVCL_B9VC - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=75d4b88a-a906-4f08-a9f8-66490328b9f1" - icNF09.5: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF18.1a." - meaning: rrid:CVCL_D3C7 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9638c45-74f3-4d0d-8bac-67631503f437" - icNF18.1a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF09.5." - meaning: rrid:CVCL_D3C8 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=347edbcd-0b43-4717-bdd2-2f6f31736e31" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08c395bc-b13c-42fa-8b99-ba6864c65928 + AsPC-1: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=15367885, PubMed=21607521, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0152 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bbfd278-a1aa-4279-b648-94efe9e1f242 + Calu-1: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=12794755, DepMap). + meaning: rrid:CVCL_0608 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=055e78dc-b3d2-416b-a7f1-ac4de9d9ec2b + Capan-1: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=8026879, PubMed=8426738, PubMed=15367885, PubMed=21750719, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0237 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efe31e45-2075-4b41-a06f-a1d5935622fa + Capan-2: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=7961102, PubMed=8026879, PubMed=8426738, PubMed=11169959, PubMed=15367885, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0026 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a32eaaa-e7cf-45a2-ae52-528a09eea541 + CFPAC-1: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=11169959, PubMed=11787853, PubMed=15367885, Cosmic-CLP). + meaning: rrid:CVCL_1119 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6f287de-eadb-4020-be7a-5b761172fec6 + COLO 668: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1128 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a57bc0e-51ee-4a44-a872-2ed8ab56f4c6 + COR-L23: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1139 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6928d53-c913-4078-8354-4a5de3d5c824 + DAN-G: + description: 2 alleles of G12V mutation in KRAS gene. Established from a xenograft produced by implantation of cells from the tumor of a patient with cancer of the pancreas in a nude mouse (CLS). Mutation of KRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (CLS, Cosmic-CLP). + meaning: rrid:CVCL_0243 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=99359d65-6e01-410d-be59-217aa0bfb9c9 + GP2d: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap). + meaning: rrid:CVCL_2450 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c62fab0b-8aa2-4732-9ffb-7d80b8b425ab + HCT 116: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0291 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=077ce9fd-c141-4baa-b8ac-80aa2922a041 + HCT 15: + description: 1 alleles of G13D mutation in KRAS gene + meaning: rrid:CVCL_0292 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dc12b0e-f9e9-4486-a923-720a8a36bb4e + HPAF-II: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11787853, PubMed=12068308, PubMed=15367885, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0313 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd37b60c-e8f7-451a-87e2-20792451c6fe + HuP-T4: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1300 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1e7bf984-5c1f-463e-89e1-b5d9b552aef5 + KP-3: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=21607521, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_3005 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a550816-e561-4d4b-a25c-995ea23b8a41 + LCLC-97TM1: + description: 2 alleles of G12V mutation in KRAS gene + meaning: rrid:CVCL_1376 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7fe3fbf-d242-40b6-9d33-c19e8e0057e0 + LoVo: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0399 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5ce9c8-7f59-43b0-ac57-3a883d75dff3 + LS180: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=20570890, PubMed=24755471, ATCC). + meaning: rrid:CVCL_0397 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54b8989a-e04f-47ac-bc0c-a5871b943228 + LS513: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471). + meaning: rrid:CVCL_1386 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f95c38-f30f-4ce8-8a92-97baecbc53fc + Lu-65: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1392 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6365e6d0-eefd-4778-9e0f-d8c549838ff2 + Lu-99: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap). + meaning: rrid:CVCL_3015 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31448c47-8e6d-412c-917a-9f92c53ad687 + MIA PaCa-2: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=7961102, PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=12068308, PubMed=21607521, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0428 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee325d43-d215-4610-aa67-011ea95efaab + NCI-H1373: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, DepMap). + meaning: rrid:CVCL_1465 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a14754e6-1c26-4224-9ef9-a1abfd1538eb + NCI-H1385: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap). + meaning: rrid:CVCL_1466 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=93469888-1234-4f52-b3a7-175423b817cc + NCI-H1792: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1495 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d28192f0-d180-40e1-b184-de3fed398e72 + NCI-H1944: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1508 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e3ae7e3f-d6ae-48d9-8e08-e2625c048642 + NCI-H2030: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1517 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177c35b5-d859-4bf2-870b-9311ef059159 + NCI-H2122: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1531 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=12d08160-d127-463a-9e6e-c62347f9e756 + NCI-H23: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=17088437). + meaning: rrid:CVCL_1547 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95e9ea19-3d84-43a5-b003-347ecec6b1fa + NCI-H2444: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1552 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=da179d37-bc2d-4725-8621-f8ec49b917d0 + NCI-H358: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=9649128, PubMed=12068308). + meaning: rrid:CVCL_1559 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cca5b217-ce0b-4c2b-814f-54fefb967475 + NCI-H441: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1561 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=665f978b-9fec-4f0b-8921-058a94b84bcd + NCI-H647: + description: 2 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1574 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df53b267-e448-4051-a0d8-1db4da3c5c41 + NCI-H727: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1584 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d124e590-59ba-44c6-9c9f-0b0a3c96862c + NCI-H747: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1587 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06004dd0-1122-46cc-b049-8349d9511c64 + Panc 02.03: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1633 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21237832-d6ba-422e-80ec-36a3ae6d7c7a + Panc 03.27: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1635 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2acf94e6-185b-4717-8f04-71ac8b6d62e3 + Panc 04.03: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1636 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177e4c5c-f9dd-4695-a3ca-fb9205aae724 + Panc 08.13: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=9612602, ATCC). + meaning: rrid:CVCL_1638 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d861eabe-95d4-47d7-bbb9-be13f7db26f6 + Panc 10.05: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1639 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf2cfa90-a8cd-4ae4-ad5d-2ab86eddd313 + PaTu 8902: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1845 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ead740e0-7ced-4d3c-b411-207cd8f7ae74 + PK-1: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap). + meaning: rrid:CVCL_4717 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53f296e1-638f-44af-8a6f-e9dd601586b0 + PK-45H: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (DepMap). + meaning: rrid:CVCL_6748 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e18db26-a0c8-4418-8c64-a73d3fa7e8af + PK-59: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap). + meaning: rrid:CVCL_4897 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f1d08c5-73a8-47e5-b113-031c6a55316d + QGP-1: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=21607521, PubMed=29444910, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_3143 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3b46e6a-030c-4f5e-8d86-d0f540d31edb + RCM-1: + description: 2 alleles of G12V mutation in KRAS gene. Mutation, KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1648 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c003a385-2de1-4ee8-a2d3-212bb746dac9 + RERF-LC-Ad2: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (DepMap). + meaning: rrid:CVCL_1652 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6cb07c1-218d-4762-90d9-4de228447635 + SHP-77: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1693 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b177ff32-b33c-4327-8862-e5b23994b502 + SK-CO-1: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0626 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e7d6716-540f-4206-a32e-4b7ca4b4c53e + SK-LU-1: + description: 1 alleles of G12D mutation in KRAS gene. Cell line positive for alternative lengthening of telomeres (ALT+). Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=1855224, PubMed=12068308, PubMed=12794755, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0629 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=903d9857-0c45-4817-a8d6-b43490a3fbcb + SNU-407: + description: 1 alleles of G12D mutation in KRAS gene, KRAS codon 12 GGT->GAT. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=10362137, Cosmic-CLP). + meaning: rrid:CVCL_5058 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a05a7478-548d-4e6b-b7d0-17891a503e06 + SNU-C2A: + description: 1 alleles of G12D mutation in KRAS gene. Established from a nude mouse xenograft. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap). + meaning: rrid:CVCL_1709 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c51a1afa-d499-4630-8995-a61c9fd733b1 + SU.86.86: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Hemizygous (PubMed=11115575). + meaning: rrid:CVCL_3881 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=69abfb3f-7d1e-4433-b542-909b794dd72f + SW1463: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=28683746, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1718 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42a7d7eb-f6df-45b8-80fc-242650606a84 + SW1573: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, ATCC, Cosmic-CLP). + meaning: rrid:CVCL_1720 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b600b899-2a05-44bb-bc3a-3359a45fa2f9 + SW1990: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1723 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d519727-94e9-4f9e-95d3-9227443c03fe + SW403: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0545 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed7ecfd-36d3-4573-8e07-210c6088c3a7 + SW480: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=20570890, PubMed=24755471, PubMed=28683746, DepMap). + meaning: rrid:CVCL_0546 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b79f24b-7362-4687-8c66-03bcb6a26ab3 + SW620: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746). + meaning: rrid:CVCL_0547 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cf15506-fb63-49a8-b36e-6a28a67b4c6d + SW837: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746). + meaning: rrid:CVCL_1729 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8a15b9-b7b8-42b7-ae4e-ca3ae1ac0be7 + SW900: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, Cosmic-CLP). + meaning: rrid:CVCL_1731 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=880c525a-f1df-49df-afe5-61ad07304c6a + T3M-10: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap). + meaning: rrid:CVCL_8067 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c2fbf5a-1c45-43f0-87bb-bb97ea9062f0 + T84: + description: 1 alleles of G13D mutation in KRAS gene. Established from a xenograft produced by subcutaneous injection of the tumor cells into BALB/c nude mice. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=20570890, PubMed=24755471, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0555 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=281f0309-ec7d-443a-850f-9327e36c9b9f + YAPC: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1794 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f51cbf29-987e-4950-9b46-1a607d5413a1 + 2-004: + description: Patient-derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b44907f-47e9-470f-918e-03e55cc9eff9 + BTSC 232: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4d9d286-d169-41d0-8dc8-45bc92984aaf + BTSC 233: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b664f320-dd73-4aae-82e7-91c42b48744a + BTSC 3021: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f98c4bb5-b168-431a-8642-f769bed673a3 + BTSC 3047: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=852b8fa5-892d-4353-9d6b-4673396ca999 + BTSC 349: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ea69fa4e-4393-4ffe-a5a8-f4df59789813 + BTSC 380: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98790fc2-9cdf-442c-94d2-e6775cfb8ad3 + c.1149C > A NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ec8883f5-db93-4c66-9970-792b71b653ac + c.1185+1G > A NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3978a8ca-aad8-49f5-a513-70b5acd0f92e + c.3431-32_dupGT NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=831ba769-4809-4e31-9214-23bfb0377c19 + c.5425C > T NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5dbc86-c52d-4713-8a03-ddf3ae42695f + c.6619C > T NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13be6b59-6b84-4d38-add9-3e87631bddf3 + HS53T: + description: human NF1-associated MPNST derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86dcdce8-8416-4157-a31e-04c6edd3ca65 + HSC1λ: + description: human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0193c87-8813-4841-92e7-ee5095bd94fe + JH-2-002: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1bc84ef2-208f-4f0e-8045-6be47fd968de + JH-2-009: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0bc812b4-f2af-40c4-8245-1070ab12f627 + JH-2-031: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4241b7ff-c08e-4c6d-b2c1-9de9ac91f72b + MPNST 724: + description: human MPNST cell line + meaning: rrid:CVCL_AU20 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7db6b49f-7eec-4b47-bbdc-675a8a464735 + N10: + description: N5 and N10 cells lines underwent CRISPR/Cas9 targeting against NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de94c5d9-6feb-402f-a0c6-6ac3389907c6 + NF1-/- hiPSC-SCPs: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc7520bc-3deb-43c2-81e9-b71cbf4daa65 + NF1+/- hiPSC-SCPs: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa3052b-d40a-4f73-b12e-b68c472497bb + NF10.1: + description: NF1-deficient MPNST tumor cell line from an NF1 patient. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2e468b4-b8cf-4473-b5f5-b7f47415d40f + NF11.1: + description: NF1-deficient MPNST tumor cell line from an NF1 patient. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc674458-affb-46a3-8a48-90fe556b44d1 + NF1C-FiPS-SV4F7: + description: NF1(-/-) iPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=00f8dcc6-a2b2-4fc2-a327-e87367bffa21 + NF1‐iN: + description: fibroblasts cell lines from a NF1 patient + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e608c5ee-fd65-4a08-9c89-9bf16f83956f + NMS-PC: + description: human MPNST cell lines + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c7fb76f-0aae-4e0c-9a69-f50f6a5c5ebb + A68: + description: From a surgically excised pNF specimen of a 51-year-old female with NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=328fd785-453d-4a09-be93-b7da67d9d33e + WZJ: + description: From a surgically excised pNF specimen of a 12-year-old boy with NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb814003-cd22-430d-a3b7-e387ef8eac76 + S462s: + description: Human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c655750-7b47-4cd1-bc5d-2bc6246f5e26 + S462sp: + description: MPNST-derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ab6c976-dbd3-4616-9911-23f4981fa5c5 + SOX10+ SLC: + description: Human induced pluripotent stem cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3e07933-db64-48ea-bfa5-ed22a8647770 + U87-NF1-419: + description: Generated U87-NF1-419 to evaluate the role of circNF1-419 on cell cycle, apoptosis, proliferation, tumor growth and metabolic regulation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8eee8013-cc31-43a4-903e-a5db2201e5f0 icNF93.1a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. meaning: rrid:CVCL_D3C9 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dcf74355-dce9-4eac-bfda-00984a4e7f3c" - icNF97.2a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2a)." - meaning: rrid:CVCL_B9V3 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a731535e-f7a6-4c6e-b0db-7f0d0979e69f" - icNF97.2b: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2b)." - meaning: rrid:CVCL_B9V4 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb920757-ad44-4705-815e-31b5bd6105f5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dcf74355-dce9-4eac-bfda-00984a4e7f3c icNF97.5: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. meaning: rrid:CVCL_D3CA - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3003d963-fb4b-44e0-9b4c-97c5df6d6661" - icNF98.4c: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4c)." - meaning: rrid:CVCL_B9V7 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46da7a41-c654-426e-bfb7-361caf4d3c4c" - icNF98.4d: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4d)" - meaning: rrid:CVCL_B9V8 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd74fd9f-6357-40d5-8569-96883628fb1a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3003d963-fb4b-44e0-9b4c-97c5df6d6661 icNF99.1: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. meaning: rrid:CVCL_D3CB - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27004264-d872-493f-8668-ec4d2425cdc2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27004264-d872-493f-8668-ec4d2425cdc2 + icNF09.5: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF18.1a. + meaning: rrid:CVCL_D3C7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9638c45-74f3-4d0d-8bac-67631503f437 + icNF18.1a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF09.5. + meaning: rrid:CVCL_D3C8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=347edbcd-0b43-4717-bdd2-2f6f31736e31 ipNF08.1.5: - description: "An hTERT/CDK4-immortalized plexiform neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized plexiform neurofibroma cell line derived from a primary cell culture. meaning: rrid:CVCL_D3CC - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878d9455-2383-4427-88b3-de4fb28de131" - sNF02.2: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_K280 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b72d99fd-ee1e-42ec-92b6-9f89e375cce1" - sNF94.3: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_K164 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504647eb-6b60-492a-bb51-3ab025830f51" - sNF96.2: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_K281 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c9a87975-378b-4930-8fda-e5896c42c86c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878d9455-2383-4427-88b3-de4fb28de131 + HS-PSS: + description: A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be. + meaning: rrid:CVCL_8717 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd49d4e2-575e-4e89-8317-cff02db4882c + HS-Sch-2: + description: A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be. + meaning: rrid:CVCL_8718 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19bba596-fc3d-479b-9675-afa369b44dee CellLineModelManual: permissible_values: AC007-hTERT: @@ -8776,6 +8826,21 @@ enums: description: DNA (deoxyribonucleic acid) is a polymer of nucleotides and is the genetic material in organisms and some viruses. Polymeric nanoparticles: description: 'Polymeric nanoparticles (PNPs) are solid and spherical (in most cases) structures prepared from natural or synthetic polymers with drug delivery being known to be one of the most important biomedical applications (reference: Hirvonen et al., Nanoengineered Biomaterials for Advanced Drug Delivery, 2020)' + ModelSystemTypeEnum: + description: Categories of model systems used in research + permissible_values: + cell line: + description: Cultured cell line maintained in vitro + meaning: OBI:0001868 + animal model: + description: Non-human animal model organism used to study disease or biological processes + meaning: OBI:0000659 + organoid: + description: Three-dimensional cell culture model that mimics organ structure and function + meaning: CLO:0037106 + patient-derived xenograft: + description: Tumor tissue from a patient transplanted into an immunodeficient animal model + meaning: EFO:0004939 SpeciesEnum: permissible_values: Danio rerio: @@ -9262,109 +9327,6 @@ classes: slot_usage: species: ifabsent: string(Homo sapiens) - DataLandscape: - attributes: - study: - description: 'Study context: The study or project that this dataset belongs to' - range: string - required: true - title: Study - aim: - description: 'Study context: The research aim within the study and associated with the expected dataset (e.g., 1 for Aim 1, 2 for Aim 2)' - range: integer - required: false - title: Associated Aim - name: - description: 'Dataset identification: Short, unique name/label that will be used for the folder storing the data. For example, with RNA Sequencing data in multiple aims, label them "RNA Sequencing - Aim 1", "RNA Sequencing - Aim 2", etc. The associated sample cohort or species can also be used to help distinguish datasets.' - range: string - required: true - title: Dataset Name - description: - description: 'Dataset identification: Short description of the dataset and experimental details.' - range: string - required: false - title: Description - dataLead: - description: 'Dataset identification: The person or team responsible for generating and curating this dataset' - range: string - required: false - title: Data Lead - dataType: - description: 'Scientific characteristics: The type of data that will be uploaded in this dataset. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' - multivalued: true - any_of: - - range: Data - - range: UnknownEnum - required: false - title: Type - assay: - description: 'Scientific characteristics: The assay or experimental method used to generate this dataset. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' - any_of: - - range: SequencingAssayEnum - - range: ImagingAssayEnum - - range: MassSpectrometryAssayEnum - - range: ClinicalBehavioralAssayEnum - - range: CellBasedAssayEnum - - range: DrugScreenAssayEnum - - range: UnknownEnum - required: true - title: Assay - species: - description: 'Scientific characteristics: The species from which sample data were derived. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' - any_of: - - range: SpeciesEnum - - range: UnknownEnum - required: true - title: Species - fileFormat: - description: 'Scientific characteristics: The primary file format(s) expected in this dataset. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' - multivalued: true - any_of: - - range: SequencingFileFormatEnum - - range: ImagingFileFormatEnum - - range: ArrayFileFormatEnum - - range: MassSpecFileFormatEnum - - range: TabularFileFormatEnum - - range: ScriptFileFormatEnum - - range: DataFileFormatEnum - - range: ArchiveFileFormatEnum - - range: DocumentFileFormatEnum - - range: OtherFileFormatEnum - - range: UnknownEnum - required: true - title: File format - nSamples: - description: 'Quantitative estimates: Expected number of samples in the dataset. This can be an estimate.' - range: integer - required: true - title: Number of Samples - nFiles: - description: 'Quantitative estimates: Expected number of files in the dataset. This can be an estimate.' - range: integer - required: true - title: Number of Files - deadline: - description: 'Project management: Target date for data to be uploaded for this dataset. This can be an estimate.' - range: date - required: false - title: Data Upload Deadline - milestone: - description: 'Project management: Reference to a milestone (aka "progress report number") associated with this dataset, e.g. ''1'' or ''2.2''' - range: string - required: false - title: 'Associated Milestone' - comments: - description: 'Project management: Additional comments or notes about this dataset' - range: string - required: false - title: Comments - description: Template for planning and tracking datasets to be deposited in a study. Complete details below about the datasets you expect to upload for this study. These datasets will be automatically generated as folders in your Synapse project. "Upload by" dates, "#Files", and "#Samples" can be estimates. - notes: - - This template is used for dataset contribution planning - - The label should be unique within a project and will be used as the folder name - - All numeric fields and dates can be estimates - - If appropriate terms are not found, contact nf-osi@sagebase.org - title: Datasets Expected FileBasedTemplate: abstract: true description: 'Abstract template for metadata on file-based resources, i.e. data artifacts stored as files.' @@ -9384,7 +9346,7 @@ classes: - FileBasedTemplate and RecordBasedTemplate are not technically mutually exclusive; some resources may have both file and record representations. BiologicalAssayDataTemplate: abstract: true - description: 'A template defining basic metadata on deposited data artifacts (i.e. files) from experimental assays involving biosamples. Donor/individual attributes (species, sex, age, diagnosis) describe the original donor (e.g., human patient tumor). For cell lines, individualID references syn51730943. Model attributes (modelSpecies, modelSex, modelAge) describe any animal model host used. antibodyID and geneticReagentID reference treatments/reagents.' + description: 'A template defining basic metadata on deposited data artifacts (i.e. files) from experimental assays involving biosamples. Donor/individual attributes (species, sex, age, diagnosis) describe the original donor (e.g., human patient tumor). For cell lines, individualID references syn51730943. Model attributes (modelSystemType, modelSpecies, cellLineCategory, cellLineGeneticDisorder, modelSystemName, modelSex, modelAge) describe model system used. Filter fields (modelSystemType, modelSpecies, cellLineCategory, cellLineGeneticDisorder) must appear before modelSystemName to enable conditional filtering in Synapse curator grid. antibodyID and geneticReagentID reference treatments/reagents.' is_a: FileBasedTemplate slots: - dataType @@ -9399,8 +9361,11 @@ classes: - nf1Genotype - nf2Genotype - tumorType - - modelSystemName + - modelSystemType - modelSpecies + - cellLineCategory + - cellLineGeneticDisorder + - modelSystemName - modelSex - modelAge - modelAgeUnit @@ -10478,6 +10443,109 @@ classes: range: MassSpectrometryPlatformEnum fileFormat: range: MassSpecFileFormatEnum + DataLandscape: + attributes: + study: + description: 'Study context: The study or project that this dataset belongs to' + range: string + required: true + title: Study + aim: + description: 'Study context: The research aim within the study and associated with the expected dataset (e.g., 1 for Aim 1, 2 for Aim 2)' + range: integer + required: false + title: Associated Aim + name: + description: 'Dataset identification: Short, unique name/label that will be used for the folder storing the data. For example, with RNA Sequencing data in multiple aims, label them "RNA Sequencing - Aim 1", "RNA Sequencing - Aim 2", etc. The associated sample cohort or species can also be used to help distinguish datasets.' + range: string + required: true + title: Dataset Name + description: + description: 'Dataset identification: Short description of the dataset and experimental details.' + range: string + required: false + title: Description + dataLead: + description: 'Dataset identification: The person or team responsible for generating and curating this dataset' + range: string + required: false + title: Data Lead + dataType: + description: 'Scientific characteristics: The type of data that will be uploaded in this dataset. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' + multivalued: true + any_of: + - range: Data + - range: UnknownEnum + required: false + title: Type + assay: + description: 'Scientific characteristics: The assay or experimental method used to generate this dataset. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' + any_of: + - range: SequencingAssayEnum + - range: ImagingAssayEnum + - range: MassSpectrometryAssayEnum + - range: ClinicalBehavioralAssayEnum + - range: CellBasedAssayEnum + - range: DrugScreenAssayEnum + - range: UnknownEnum + required: true + title: Assay + species: + description: 'Scientific characteristics: The species from which sample data were derived. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' + any_of: + - range: SpeciesEnum + - range: UnknownEnum + required: true + title: Species + fileFormat: + description: 'Scientific characteristics: The primary file format(s) expected in this dataset. If you are unsure or cannot find the appropriate term, please use ''Unknown'' and email nf-osi@sagebase.org for help.' + multivalued: true + any_of: + - range: SequencingFileFormatEnum + - range: ImagingFileFormatEnum + - range: ArrayFileFormatEnum + - range: MassSpecFileFormatEnum + - range: TabularFileFormatEnum + - range: ScriptFileFormatEnum + - range: DataFileFormatEnum + - range: ArchiveFileFormatEnum + - range: DocumentFileFormatEnum + - range: OtherFileFormatEnum + - range: UnknownEnum + required: true + title: File format + nSamples: + description: 'Quantitative estimates: Expected number of samples in the dataset. This can be an estimate.' + range: integer + required: true + title: Number of Samples + nFiles: + description: 'Quantitative estimates: Expected number of files in the dataset. This can be an estimate.' + range: integer + required: true + title: Number of Files + deadline: + description: 'Project management: Target date for data to be uploaded for this dataset. This can be an estimate.' + range: date + required: false + title: Data Upload Deadline + milestone: + description: 'Project management: Reference to a milestone (aka "progress report number") associated with this dataset, e.g. ''1'' or ''2.2''' + range: string + required: false + title: 'Associated Milestone' + comments: + description: 'Project management: Additional comments or notes about this dataset' + range: string + required: false + title: Comments + description: Template for planning and tracking datasets to be deposited in a study. Complete details below about the datasets you expect to upload for this study. These datasets will be automatically generated as folders in your Synapse project. "Upload by" dates, "#Files", and "#Samples" can be estimates. + notes: + - This template is used for dataset contribution planning + - The label should be unique within a project and will be used as the folder name + - All numeric fields and dates can be estimates + - If appropriate terms are not found, contact nf-osi@sagebase.org + title: Datasets Expected PortalDataset: attributes: accessType: diff --git a/docs/conditional-enum-filtering-plan.md b/docs/conditional-enum-filtering-plan.md new file mode 100644 index 00000000..102d3ce1 --- /dev/null +++ b/docs/conditional-enum-filtering-plan.md @@ -0,0 +1,307 @@ +# Conditional Enum Filtering Implementation Plan + +## Problem Statement + +Multiple schema fields have enum values exceeding Synapse's 100-value column limit: +- `modelSystemName`: 809 values (638 cell lines + 122 animal models + 49 other) +- `assay`: 202 values +- `fileFormat`: 118 values +- `platform`: 122 values +- `institutions`: 331 values (PortalStudy only) + +**Current Issue**: Truncating to first 100 values loses most valid options and provides poor UX. + +## Proposed Solution + +Implement **conditional enum filtering** using progressive field dependencies that reduce available options based on user selections in prior fields. + +### Strategy + +Use multi-level cascading filters: + +``` +Level 1: modelSystemType → reduces 809 to ~638 or ~122 +Level 2: modelSpecies → reduces further by species +Level 3: diagnosis/tumorType → optional additional filtering +Result: modelSystemName → <100 values shown +``` + +--- + +## Implementation Plan + +### 1. Add Model System Type Field + +Add a new `modelSystemType` field to distinguish resource categories: + +```yaml +# In modules/Sample/props.yaml or similar +modelSystemType: + description: "Type of model system used in the study" + range: ModelSystemTypeEnum + +enums: + ModelSystemTypeEnum: + permissible_values: + cell line: + description: "Cultured cell line" + animal model: + description: "Animal model organism" + organoid: + description: "3D cell culture model" + patient-derived xenograft: + description: "PDX model" +``` + +### 2. Enrich Truth Table Data + +**Option A (Recommended)**: Add species column to syn26450069 + +Query Cellosaurus/MGI APIs to populate species for each resource: +- Cell lines → usually Homo sapiens or Mus musculus +- Animal models → extract from genotype name + +**Option B**: Create species mapping file + +Generate `utils/model_system_species_mapping.yaml`: +```yaml +species_mapping: + "HEK293": "Homo sapiens" + "Nf1+/-": "Mus musculus" + # ... etc +``` + +### 3. Create Enum Subsets + +Split `modelSystemName` into contextual subsets: + +```yaml +# modules/Sample/CellLineModel.yaml (existing, enhance with species subsets) +enums: + HumanCellLineModel: + permissible_values: + HEK293: {...} + # ~434 human cell lines + + MouseCellLineModel: + permissible_values: + # ~150 mouse cell lines + + # Other species... +``` + +```yaml +# modules/Sample/AnimalModel.yaml (existing, enhance with species subsets) +enums: + MouseAnimalModel: + permissible_values: + "Nf1+/-": {...} + # ~100 mouse models + + RatAnimalModel: + permissible_values: + # ~15 rat models +``` + +### 4. Add Conditional Dependencies to JSON Schema + +Update schema generation to add `if/then/else` conditionals: + +```json +{ + "allOf": [ + { + "if": { + "properties": { + "modelSystemType": { "const": "cell line" }, + "modelSpecies": { "const": "Homo sapiens" } + }, + "required": ["modelSystemType", "modelSpecies"] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "enum": ["HEK293", "HeLa", "MCF-7", "..."] + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { "const": "animal model" }, + "modelSpecies": { "const": "Mus musculus" } + }, + "required": ["modelSystemType", "modelSpecies"] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "enum": ["Nf1+/-", "Nf1fl/fl", "..."] + } + } + } + } + } + ] +} +``` + +### 5. Reorder Schema Fields + +Ensure filter fields appear before filtered fields: + +**Current order**: +``` +1. platform +2. assayTarget +... +18. modelSpecies +19. modelSystemName +... +``` + +**Proposed order**: +``` +1. modelSystemType (NEW - primary filter) +2. modelSpecies (moved up - secondary filter) +3. diagnosis (moved up - optional tertiary filter) +4. tumorType (moved up - optional tertiary filter) +5. modelSystemName (filtered by above) +6. platform +7. assayTarget +... +``` + +### 6. Update Entity View Code + +Modify `utils/json_schema_entity_view.py` to handle conditional enums: + +```python +def _create_columns_from_json_schema(json_schema: dict[str, Any]) -> list[Column]: + """Creates columns, respecting conditional enum constraints.""" + + # Extract conditional rules from allOf + conditional_enums = _extract_conditional_enums(json_schema) + + for name, prop_schema in properties.items(): + # Check if this field has conditional enums + if name in conditional_enums: + # Strategy: Use the UNION of all conditional enum values + # Or: Don't set enum constraint at column level (let DCA/validation handle it) + all_possible_values = _get_union_of_conditional_enums(conditional_enums[name]) + if len(all_possible_values) > 100: + # Too many even with conditionals - no column constraint + enum_values = None + else: + enum_values = all_possible_values[:100] + else: + # Regular enum handling + if "enum" in prop_schema: + enum_list = prop_schema["enum"] + enum_values = enum_list[:100] if len(enum_list) > 100 else enum_list +``` + +**Note**: Synapse columns don't support dynamic enums, so we have two options: +- **Option A**: Set no enum constraint on column (free text), rely on DCA validation +- **Option B**: Set union of all possible values (if <100), DCA shows contextual subset + +### 7. Data Curator App Integration + +The DCA needs to: +1. Parse `if/then/else` conditionals from JSON Schema +2. Update `modelSystemName` dropdown dynamically when `modelSystemType` or `modelSpecies` changes +3. Show only contextually relevant values + +**This may require DCA updates** - check with DCA team. + +--- + +## Expected Results + +### Before +- `modelSystemName`: 809 values → truncated to 100 → users can't find their model + +### After +- User selects `modelSystemType = "cell line"` + - `modelSystemName` options reduce to 638 cell lines +- User selects `modelSpecies = "Homo sapiens"` + - `modelSystemName` options reduce to ~87 human cell lines ✅ Under 100! +- User selects `modelSpecies = "Mus musculus"` + - `modelSystemName` options reduce to ~150 mouse cell lines → still over 100 + - Need additional filter (diagnosis, or split further by category) + +### Breakdown by Species (estimated): + +**Cell Lines** (638 total): +- Homo sapiens: ~434 (still need filter) +- Mus musculus: ~150 (still need filter) +- Other: ~54 ✅ + +**Animal Models** (122 total): +- Mus musculus: ~100 ✅ (just under limit!) +- Other: ~22 ✅ + +**Still problematic**: Human cell lines. Need additional dimension: +- Could filter by cell line type (iPSC, primary, immortalized, cancer) +- Could filter by NF genotype (NF1+/-, NF1-/-, WT) +- Could filter by disease/tumor type + +--- + +## Alternative Approaches + +### Approach 1: No Column Enum Constraint +**Simplest**: Don't set `enum_values` on Synapse column for fields >100. +- ✅ Immediate fix +- ❌ No dropdown in Synapse UI +- ✅ DCA can still validate against full schema + +### Approach 2: Separate Fields by Type +Create distinct fields instead of one polymorphic field: +- `cellLineModelSystemName` (638 values) +- `animalModelSystemName` (122 values) + +**Pros**: Clearer semantics +**Cons**: Schema changes, backward compatibility issues + +### Approach 3: Free Text + Autocomplete +Remove enum entirely, make modelSystemName free text with autocomplete hints. +- ✅ No limits +- ❌ Less validation, more typos + +--- + +## Recommended Next Steps + +1. **Validate approach with DCA team** - Confirm DCA can handle conditional enums +2. **Add species to truth table** - Coordinate with data stewards +3. **Implement for modelSystemName first** - Prove the pattern +4. **Apply to other large enums** - Extend to assay, fileFormat, platform +5. **Update documentation** - Add to DESIGN.md + +--- + +## Questions for Discussion + +1. **Can DCA parse and respect if/then/else conditionals from JSON Schema?** +2. **Should we add species column to syn26450069, or maintain a mapping file?** +3. **For human cell lines (434 values), what additional filter dimension makes sense?** + - Cell line category (iPSC, cancer, primary, immortalized)? + - NF genotype (NF1+/-, NF1-/-, NF2-/-, WT)? + - Tumor/tissue type? +4. **Should we implement this for all templates, or start with a pilot (e.g., ImagingAssayTemplate)?** + +--- + +## Success Criteria + +✅ All filter fields appear before filtered fields in schema +✅ JSON Schema has valid if/then/else conditionals +✅ Each conditional branch has <100 enum values +✅ DCA shows contextual dropdown options +✅ Synapse entity view creation succeeds (no 400 errors) +✅ Users can search full list of valid values through progressive filtering diff --git a/modules/Sample/AnimalModel.yaml b/modules/Sample/AnimalModel.yaml index 09474a7f..af9a54eb 100644 --- a/modules/Sample/AnimalModel.yaml +++ b/modules/Sample/AnimalModel.yaml @@ -1,333 +1,408 @@ -# WARNING: This file is auto-generated from Synapse table syn26450069 +# WARNING: This file is auto-generated from Synapse table syn51730943 # DO NOT EDIT DIRECTLY - changes will be overwritten # For manual entries, use the corresponding *Manual.yaml file -# Generated by utils/sync_model_systems.py +# Generated by utils/sync_model_systems_enhanced.py enums: AnimalModel: permissible_values: - "129-Nf1/Nci": - description: "Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58b28d42-aa4f-496f-be70-257e8d1a95c6" - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+": - description: "Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b8b5bd4-a085-4788-ae0e-dadf5def4b8b" - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-": - description: "Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d59c28f-a132-4b3c-a52e-31da039647ca" - "B6-129S4-Nf1-/+;Trp53-/+cis": - description: "B6X129S4 F1 hybrid" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9474c772-2e68-4f02-b0c8-f962f731d175" - "B6.129(Cg)-Nf1tm1Par/J": - description: "[From JAX]: These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I." + NF1flox4/Arg681*;Dhh-Cre: + description: '[From GFF:] A nonsense mutation recapitulating the human variant + c.2041C>T in which an arginine at position 681 was changed to a chain-terminating + codon (Arg681*) AND NF1 exon 4 floxed allele. Dhh-Cre induces inactivation + of NF1 flox allele in glial lineage cells beginning at E12.5' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=033b7173-4c58-410e-b441-579ba05c388a + Nf1tm1d(KOMP)Wtsi: + description: '[From GFF:] EUCOMM identified critical exon 4 is flanked by + loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase + expression in mice carrying this allele. The knockout allele was created + by deletion exon 4 through subsequent cre-mediated recombination.' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ecabd72-d36c-487e-8c0e-c05e3dd743ba + B6.129(Cg)-Nf1tm1Par/J: + description: '[From JAX]: These mice possess loxP sites flanking exons 31-32 + of the neurofibromatosis 1 (Nf1) gene and have applications in studies of + cancer, neural crest development and neurofibromatosis type I.' meaning: rrid:IMSR_JAX:017640 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118aa95e-27f4-48fa-94c7-5f786b8b4f2f" - "B6.129S1-Nf1tm1Cbr/J": - description: "[From JAX]: Mice homozygous for this targeted allele (Nf123a-/-) lack the alternatively spliced exon 23a (which modifies the GTPase-activating protein (GAP) domain of Nf1). These mutant mice may be useful for neurological studies of Neurofibromatosis Type I, growth, differentiation, and learning and memory." - meaning: rrid:IMSR_JAX:007923 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=893695cf-daa7-42eb-998c-9b04af941964" - "B6.129S2-Nf1tm1Tyj/J": - description: "[From JAX]: Heterozygous animals do not exhibit the classical symptoms of Human neurofibromatosis type 1, but are highly predisposed to the formation of various tumor types, notably phaeochromocytoma, a tumor of the neural crest-derived adrenal medulla, and myeloid leukemia. Homozygosity leads to abnormal cardiac development and mid-gestational embryonic lethality. This strain may be useful in studies of cancer and developmental biology." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118aa95e-27f4-48fa-94c7-5f786b8b4f2f + Nf1pArg1947mp1: + description: '[From GFF:] Minipig model containing a recurrent nonsense mutation + p.Arg1947*(R1947*) and HindIII RFLP site resulting in frame shift mutation' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=209c16d7-c1fa-414f-8f08-458eaefc2259 + Nf1tm1c(KOMP)Wtsi: + description: '[From GFF:] EUCOMM identified critical exon 4 is flanked by + loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase + expression in mice carrying this allele.' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=361988eb-d390-4f40-b01b-acee637e2271 + B6.129S2-Nf1tm1Tyj/J: + description: '[From JAX]: Heterozygous animals do not exhibit the classical + symptoms of Human neurofibromatosis type 1, but are highly predisposed to + the formation of various tumor types, notably phaeochromocytoma, a tumor + of the neural crest-derived adrenal medulla, and myeloid leukemia. Homozygosity + leads to abnormal cardiac development and mid-gestational embryonic lethality. + This strain may be useful in studies of cancer and developmental biology.' meaning: rrid:IMSR_JAX:008192 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45638793-f2d0-4c40-8b1c-be1f1b0c0f93" - "B6.129S6-Nf1/Nci": - description: "Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f9ca98a1-b5c5-423c-a4bd-db143975aa1c" - "B6.129S6-Nf1tm1Fcr/J": - description: "[From GFF:] GEM mouse in which Exon 31 of Nf1 has been disrupted in one allele" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45638793-f2d0-4c40-8b1c-be1f1b0c0f93 + B6.129S6-Nf1tm1Fcr/J: + description: '[From GFF:] GEM mouse in which Exon 31 of Nf1 has been disrupted + in one allele' meaning: rrid:IMSR_JAX:002646 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a0ccbed-abcd-49fa-abd0-5ff7b275a1e1" - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J": - description: "EllaCre driver line." - meaning: rrid:IMSR_JAX:003724 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5511a019-88aa-43c8-86c3-ad1677c8a3d0" - "B6/JGpt-Nf1/Gpt": - description: "Conditional knockout" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27c1a639-9e98-4289-872d-f275d4e49be7" - "B6/JGpt-Nf1/Gpt": - description: Knockout - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a067f136-f956-4355-a76f-a5eec7c196f0" - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ": - description: "[From JAX]: These NPS+/- mice carry Trp53, Nf1, and Suz12 mutations on chromosome 11 (in cis) and develop high-grade gliomas and malignant peripheral nerve sheath tumors by approximately 3.5 months. They are suitable for use in applications related to the study of neurofibromatosis type 1 and tumor suppressor genes." - meaning: rrid:IMSR_JAX:027678 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9b2d8ba-de9f-4bca-9401-fe100024deba" - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J": - description: "[From JAX]: These mice carry Trp53 and Nf1 targeted mutations on the same homolog of chromosome 11 (in cis). These mutations are approximately 10 Mbp apart and may segregate independently of one another. Double heterozygotes survive an average of five months and exhibit a significant increase in the percentage of soft tissue sarcomas. About 30% of tumors from the Nf1/Trp53 cis animals stain positively for S100 (consistent with glial cell origin) and exhibit classic histological features of malignant peripheral nerve sheath tumors (MPNSTs). This strain may be useful in studies of astrocytomas/glioblastomas and tumor suppressor genes." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a0ccbed-abcd-49fa-abd0-5ff7b275a1e1 + Nf1tm1.1Kest: + description: '[From GFF:] A nonsense mutation recapitulating the human variant + c.2041C>T in which an arginine at position 681 was changed to a chain-terminating + codon (Arg681*) was introduced in exon 18 and a FRT-flanked neomycin selection + cassette was inserted in intron 17. Flp-mediated recombination removed the + selection cassette.' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504d7dfe-acf9-476c-974d-e8665095afbb + B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J: + description: '[From JAX]: These mice carry Trp53 and Nf1 targeted mutations + on the same homolog of chromosome 11 (in cis). These mutations are approximately + 10 Mbp apart and may segregate independently of one another. Double heterozygotes + survive an average of five months and exhibit a significant increase in + the percentage of soft tissue sarcomas. About 30% of tumors from the Nf1/Trp53 + cis animals stain positively for S100 (consistent with glial cell origin) + and exhibit classic histological features of malignant peripheral nerve + sheath tumors (MPNSTs). This strain may be useful in studies of astrocytomas/glioblastomas + and tumor suppressor genes.' meaning: rrid:IMSR_JAX:008191 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d71c2b4-a7c5-4ced-bb45-eb98bfe42025" - "B6;CBA-Nf1/Flmg": - description: "Mice with a mutated (possibly truncated) Nf1 protein were generated using CRISPR/Cas9 technology. The mutated protein is the result of a single nucleotide deletion that takes place at exon 38 close to the targeted mutated R1809C position. A guide sgRNA along with the wild-type Cas9 protein were introduced into mouse zygotes via pronuclear microinjections." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=618a2f93-b45d-45bb-85f5-4a06929d5d8c" - "C3HeB/FeJ-Nf1/Ieg": - description: "Induced Mutant Strain: Chemically-induced" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=af2241b2-2d00-476c-bfd1-e4ebf3a99ce6" - "C57BL/6-Nf1/Mmjax": - description: "carry an R1276P missense allele" - meaning: "rrid:MMRRC_041154-JAX" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b167141d-be0c-4f87-b767-956b24161b9c" - "C57BL/6JSmoc-Nf1em1Smoc": - description: "Exon 21-23 of Nf1 gene was deleted to generate Nf1 knockout mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d8c40468-ae43-4982-b079-5ff5e8ae104e" - "C57BL/6JSmoc-Nf1tm1(flox)Smoc": - description: "These mice carry loxP sites flanking exon 31-32 of Nf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf1 gene." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ddf3618d-dda5-4c03-a4b4-b9263dba0a31" - "C57BL/6N-Nf1/Mmucd": - description: "ES cell clone EPD0033_1_F12 was injected into morulae or blastocysts. Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1a (Knockout First) animals were generated." - meaning: "rrid:MMRRC_048792-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2610c4cd-d622-4393-9087-0b007fa0567b" - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+": - description: "Transgenic mouse expressing oncogenic N-ras specifically in central nerve cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06545c3d-e098-4a67-a678-6f023fda6b88" - "CisNf1+/-; p53+/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27b4443a-06bb-454f-a253-ffb60b70a129" - "Cnp-EGFR (Pten-het/C-EGFR)": - description: "EGFR overexpression in Schwann cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2934805f-67ef-41d9-af89-64a072c66642" - "Cnp-EGFR (deltaPten/C-EGFR)": - description: "EGFR overexpression in Schwann cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98e86631-5d93-4b4a-862a-d2758420674a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d71c2b4-a7c5-4ced-bb45-eb98bfe42025 + Nf14F/4F;CAGGCre-ERTM: + description: '[From GFF:] Mice with systemic inactivation of NF1 gene following + tamoxifen induced activation of Cre transgene' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844c4e22-6d4d-454b-9ee4-53dcc7435e43 + B6.129S1-Nf1tm1Cbr/J: + description: '[From JAX]: Mice homozygous for this targeted allele (Nf123a-/-) + lack the alternatively spliced exon 23a (which modifies the GTPase-activating + protein (GAP) domain of Nf1). These mutant mice may be useful for neurological + studies of Neurofibromatosis Type I, growth, differentiation, and learning + and memory.' + meaning: rrid:IMSR_JAX:007923 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=893695cf-daa7-42eb-998c-9b04af941964 + Nf1tm2.1Kest: + description: '[From GFF:]  A point mutation, recapitulating the human missense + variant c.2542G>C, in which a glycine residue at position 848 was changed + to an arginine (p.Gly848Arg), was introduced in exon 21 and a FRT-flanked + neomycin selection cassette was inserted in intron 20. Flp-mediated recombination + removed the selection cassette. ' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e5c372e-dec8-4693-98a8-b07f3014257d + NF1SynIKO: + description: '[From GFF:] GEM mouse in which Nf1 is knocked out in neurons' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90c10d9a-c560-4722-8cbb-0e424bd417b7 + Nf1+/-GFAPCKO: + description: '[From GFF:] Mice heterozygous for a germ-line inactivating Nf1 + mutation and a conditional knock-out of NF1 in astrocytes' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9971e47e-976a-4631-8edd-5cae04304b01 + B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ: + description: '[From JAX]: These NPS+/- mice carry Trp53, Nf1, and Suz12 mutations + on chromosome 11 (in cis) and develop high-grade gliomas and malignant peripheral + nerve sheath tumors by approximately 3.5 months. They are suitable for use + in applications related to the study of neurofibromatosis type 1 and tumor + suppressor genes.' + meaning: rrid:IMSR_JAX:027678 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9b2d8ba-de9f-4bca-9401-fe100024deba + NF1fl/fl;Dhh-Cre: + description: '[From GFF:] Mice with inactivation of NF1 in glial lineage cells + beginning at E12.5' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bfa7ccaa-fee4-42bd-bc74-afe859d56fb6 + NCC-MPNST3-X2: + description: A patient-derived xenograft model created using the NCC-MPNST3-C1 + cell line. This xenograft model was used to generate the NCC-MPNST3-X2-C1 + cell line. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8a807e4-502b-461c-a60f-fd10b3cde70e + Nf14F/Arg681*;CAGGCre-ERTM: + description: '[From GFF:] Mice with systemic inactivation of NF1 gene following + tamoxifen induced activation of Cre transgene' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e70947db-35d1-448b-90d8-ec6f14e70303 + Nf1flox/-;hGFAP-Cre: + description: '[From GFF:] Mice heterozygous for a germ-line Ex31-32 Nf1 mutation + and a conditional knock-out of NF1 in astrocytes' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbf11ec4-1d12-4feb-a6fc-9faf6bc9c9db + 129-Nf1/Nci: + description: Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia + of the superior ganglia. Heterozygotes have an increased predisposition + to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. + Heterozygotes also exhibit features of the learning deficits associated + with NF1 patients, which has been shown to be associated with overactive + Ras function + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58b28d42-aa4f-496f-be70-257e8d1a95c6 + B6.129S6-Nf1/Nci: + description: Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia + of the superior ganglia. Heterozygotes have an increased predisposition + to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. + Heterozygotes also exhibit features of the learning deficits associated + with NF1 patients, which has been shown to be associated with overactive + Ras function + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f9ca98a1-b5c5-423c-a4bd-db143975aa1c + B6/JGpt-Nf1/Gpt: + description: Conditional knockout + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27c1a639-9e98-4289-872d-f275d4e49be7 + B6/JGpt-Nf1/Gpt: + description: Knockout + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a067f136-f956-4355-a76f-a5eec7c196f0 + B6;CBA-Nf1/Flmg: + description: Mice with a mutated (possibly truncated) Nf1 protein were generated + using CRISPR/Cas9 technology. The mutated protein is the result of a single + nucleotide deletion that takes place at exon 38 close to the targeted mutated + R1809C position. A guide sgRNA along with the wild-type Cas9 protein were + introduced into mouse zygotes via pronuclear microinjections. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=618a2f93-b45d-45bb-85f5-4a06929d5d8c + C3HeB/FeJ-Nf1/Ieg: + description: 'Induced Mutant Strain: Chemically-induced' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=af2241b2-2d00-476c-bfd1-e4ebf3a99ce6 + C57BL/6JSmoc-Nf1em1Smoc: + description: Exon 21-23 of Nf1 gene was deleted to generate Nf1 knockout mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d8c40468-ae43-4982-b079-5ff5e8ae104e + C57BL/6JSmoc-Nf1tm1(flox)Smoc: + description: These mice carry loxP sites flanking exon 31-32 of Nf1 gene. + When crossed with a Cre recombinase-expressing strain, this strain is useful + in eliminating tissue-specific conditional expression of Nf1 gene. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ddf3618d-dda5-4c03-a4b4-b9263dba0a31 + C57BL/6-Nf1/Mmjax: + description: carry an R1276P missense allele + meaning: rrid:MMRRC_041154-JAX + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b167141d-be0c-4f87-b767-956b24161b9c + C57BL/6N-Nf1/Mmucd: + description: ES cell clone EPD0033_1_F12 was injected into morulae or blastocysts. + Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1a (Knockout + First) animals were generated. + meaning: rrid:MMRRC_048792-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2610c4cd-d622-4393-9087-0b007fa0567b + Nf1adelta5 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e7a8732a-73ba-4d05-88a9-8d796d0f1a6b + Nf1b+10 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d5e90cc-e97a-4321-b0a5-82feed840c50 + Nf1flox/mut; GFAP-Cre: + description: NF1 conditional knock out + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4e513b5b-dde9-424d-96ff-3dd7c90f429b + Nf1-/+;Trp53-/+cis: + description: Nf1-/+;Trp53-/+ cis on mouse chromosome 11 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=426a3531-5785-4972-83ad-d88e54d2ef7f + Nf1flox/flox: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2dec4d7-24be-4218-b7b5-63349158aa15 + Nf1-/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b705a9f5-84ef-404e-9fe4-d499550298b3 + Nf1+/-: + description: heterozygous Nf1 mutant + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d27fd7b0-ed8f-4ee2-a8d9-26748c12518c + Nf1flox/-: + description: Nf1+/- mouse + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbeb0bb9-5341-496c-991a-de1e84af09b5 + 129T2/SvEmsJ::C57Bl/6NTac Nf1+/-: + description: Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac + Nf1+/- female mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d59c28f-a132-4b3c-a52e-31da039647ca + 129T2/SvEmsJ::C57Bl/6NTac Nf1+/+: + description: Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac + Nf1+/- female mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b8b5bd4-a085-4788-ae0e-dadf5def4b8b + B6-129S4-Nf1-/+;Trp53-/+cis: + description: B6X129S4 F1 hybrid + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9474c772-2e68-4f02-b0c8-f962f731d175 + CisNf1+/-; p53+/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27b4443a-06bb-454f-a253-ffb60b70a129 + Cnp-EGFR (deltaPten/C-EGFR): + description: EGFR overexpression in Schwann cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98e86631-5d93-4b4a-862a-d2758420674a + Cnp-EGFR (Pten-het/C-EGFR): + description: EGFR overexpression in Schwann cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2934805f-67ef-41d9-af89-64a072c66642 Cre(Col2.3Cre): - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19f93a61-f847-4479-ba8d-8b8a1cb3184b" - "Cx3cr1+/gfp": - description: "wild-type mouse with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaf6e2b6-2e88-4ed1-8bfc-9b803ba2d718" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19f93a61-f847-4479-ba8d-8b8a1cb3184b + Cx3cr1+/gfp: + description: wild-type mouse with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaf6e2b6-2e88-4ed1-8bfc-9b803ba2d718 DelE17: - description: "homozygous deletion of NF1 exon 17" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e00317c8-ff2c-453b-9d71-c8bf3f50a600" - "Dhh-Cre; Nf1flox/+; Ptenflox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d50930bc-c261-41a6-b517-548516044526" - "Dhh-Cre; Nf1flox/+; Ptenflox/flox": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=667881c8-e235-4d82-84af-2d1be9c6ef9b" - "Dhh-Cre; Nf1flox/flox; Ptenflox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=caa4c07e-89d1-490d-a2a8-f63bf69bc5d3" - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=507595f1-9243-48d9-bc56-e9a97904789b" - "Dhh-Cre; Ptenflox/+": - description: "Conditional Inactivation of Pten" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc6bf003-6330-4fc9-b851-8c6a3ada5d79" - "Dhh-Cre; Ptenflox/flox": - description: "Conditional Inactivation of Pten" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8941ec-d5c8-42ae-9c1b-bc4066177ec3" - "Krox20;Nf1flox/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6f865b65-5995-4243-8832-b8120fd2c36f" - "MPNST-Nf1-001": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=558a480a-0a0c-4e81-8735-2f90c7126bb0" - "MPNST-Nf1-002": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bcb3c61f-9f6d-4f04-8d5d-3ea1b63843a6" - "MPNST-Nf1-S462": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f587995-9831-4d51-99a3-a51b7607e83a" - "MPNST-SP-001": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41c369b5-25f3-4285-829f-5481b41b230e" - "MPSNT-SP-002": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2cc7762-5e1a-45d6-a4ce-029be9b42094" - "NCC-MPNST3-X2": - description: "A patient-derived xenograft model created using the NCC-MPNST3-C1 cell line. This xenograft model was used to generate the NCC-MPNST3-X2-C1 cell line." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8a807e4-502b-461c-a60f-fd10b3cde70e" - NF1SynIKO: - description: "[From GFF:] GEM mouse in which Nf1 is knocked out in neurons" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90c10d9a-c560-4722-8cbb-0e424bd417b7" - "NF1fl/fl;Dhh-Cre": - description: "[From GFF:] Mice with inactivation of NF1 in glial lineage cells beginning at E12.5" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bfa7ccaa-fee4-42bd-bc74-afe859d56fb6" - "NF1flox4/Arg681*;Dhh-Cre": - description: "[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) AND NF1 exon 4 floxed allele. Dhh-Cre induces inactivation of NF1 flox allele in glial lineage cells beginning at E12.5" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=033b7173-4c58-410e-b441-579ba05c388a" - "Nf1 +/Δ4": - description: "Mice harboring a null allele resulting from exon 4 deletion were created by breeding Nf1+/4F mice to an EIIaCre driver line (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J)." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9933922-29fb-4a4c-bc5f-604691a8bab7" - "Nf1 Arg681*/Arg681*": - description: "Created by breeding Nf1 +/Arg681* (Nf1tm1.1Kest), is embryonic lethal at day 9.5." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91e9130d-00bc-4dfe-9a5d-356e5ae3f4db" - "Nf1 GEM": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b07051a7-b584-45ae-82ad-f7bb85c1dea5" - "Nf1 Ocl-/-": - description: "Nf1-deficient osteoclasts in otherwise Nf1+/+ background" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09880210-fe90-4af9-8b1f-f886348a34eb" - "Nf1 flox/+; DhhCre/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6159b19a-c94f-4001-887f-778a8fb1e685" - "Nf1 heterozygous mutant minipig": - description: "heterozygous mutations in NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02aba952-5860-4bd9-bfb2-ff796b22bf48" - "Nf1 Δ4/Δ4": - description: "Created by breeding Nf1 +/Δ4, is embryonic lethal at day 9.5." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8984594-d5ff-4827-8e83-13ccbf0055e8" + description: homozygous deletion of NF1 exon 17 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e00317c8-ff2c-453b-9d71-c8bf3f50a600 + delta-ira1 delta-ira2 yeast: + description: delta-ira1 delta-ira2 double-knockout yeast + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b2a7ee1-e462-42b9-80b8-0a64ca60b091 + Dhh-Cre; Nf1flox/+; Ptenflox/flox: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=667881c8-e235-4d82-84af-2d1be9c6ef9b + Dhh-Cre; Ptenflox/+: + description: Conditional Inactivation of Pten + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc6bf003-6330-4fc9-b851-8c6a3ada5d79 + Dhh-Cre; Ptenflox/flox: + description: Conditional Inactivation of Pten + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8941ec-d5c8-42ae-9c1b-bc4066177ec3 + Dhh-Cre; Nf1flox/flox; Ptenflox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=caa4c07e-89d1-490d-a2a8-f63bf69bc5d3 + Dhh-Cre; Nf1flox/flox; Ptenflox/flox: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=507595f1-9243-48d9-bc56-e9a97904789b + dNf1 Drosophila: + description: Homozygous dNf1 null mutants + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7b76ccd-e646-4d30-8868-ba39541dd573 + Krox20;Nf1flox/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6f865b65-5995-4243-8832-b8120fd2c36f + miR-155 -/-;Nf1flox/flox ;DhhCre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6e61b912-8006-48cb-a122-df613c8921c4 + miR-155 +/-;Nf1flox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2470d9dd-b6c8-4cdb-ad2e-009071477c41 + miR-155 +/-;Nf1flox/+;DhhCre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a79e9847-1e32-41c8-a176-adf96a8547c0 + MPNST-Nf1-001: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=558a480a-0a0c-4e81-8735-2f90c7126bb0 + MPNST-Nf1-002: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bcb3c61f-9f6d-4f04-8d5d-3ea1b63843a6 + MPNST-Nf1-S462: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f587995-9831-4d51-99a3-a51b7607e83a + MPNST-SP-001: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41c369b5-25f3-4285-829f-5481b41b230e + MPSNT-SP-002: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2cc7762-5e1a-45d6-a4ce-029be9b42094 + Nf1 flox/+; DhhCre/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6159b19a-c94f-4001-887f-778a8fb1e685 + Nf1 heterozygous mutant minipig: + description: heterozygous mutations in NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02aba952-5860-4bd9-bfb2-ff796b22bf48 + Nf1P1/Nf1E1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=326557dc-c320-4f04-b64a-08edd703ee95 + Nf1 GEM: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b07051a7-b584-45ae-82ad-f7bb85c1dea5 Nf1(31): - description: "C57BL/6J mice with a targeted NF1 gene disruption mutation at exon 31 to mimic human NF1 mutations, knockout mutation of Nfl" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e104ac3-b954-4afa-8d87-60c3b1d80b73" - "Nf1+/-": - description: "heterozygous Nf1 mutant" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d27fd7b0-ed8f-4ee2-a8d9-26748c12518c" - "Nf1+/- P53+/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9194d4de-84b2-438a-af6e-6cdfe79ff8cb" - "Nf1+/-GFAPCKO": - description: "[From GFF:] Mice heterozygous for a germ-line inactivating Nf1 mutation and a conditional knock-out of NF1 in astrocytes" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9971e47e-976a-4631-8edd-5cae04304b01" - "Nf1+/-x129S2/SvHsd": - description: "one nf1 allele is deleted" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed66f5fd-52fd-4e83-8442-90b0676cf694" - "Nf1+/Arg681": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118cc6d8-b656-4d6a-9cff-83f2ad92e2b0" - "Nf1+/R681X": - description: "harbored a NF1-patient-derived Nf1 gene mutation (c.2041C>T;p.R681X)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8b964052-b74b-4ca3-ad82-31bd2f3457aa" - "Nf1+/ex42del pig": - description: "heterozygotic mutation in NF1 (exon 42 deletion)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57625a6e-c039-418e-8e22-db464f8aa827" - "Nf1+/Δ4": - description: "Heterozygous mice harboring a null allele resulting from exon 4 deletion" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3013cfbf-07fd-448e-8c57-cf25223eb0b4" - "Nf1-/+;Trp53-/+cis": - description: "Nf1-/+;Trp53-/+ cis on mouse chromosome 11" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=426a3531-5785-4972-83ad-d88e54d2ef7f" - "Nf1-/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b705a9f5-84ef-404e-9fe4-d499550298b3" - "Nf1-/- Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=500a5c2f-5104-405e-a243-3d85b59d6b08" - "Nf1-/-MyoD": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02afeba7-05c6-48b1-9454-efe73d9b21f2" - "Nf14F/4F; DhhCre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb4aff73-9da2-42b5-8f94-0a6084db75b0" - "Nf14F/4F;CAGGCre-ERTM": - description: "[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844c4e22-6d4d-454b-9ee4-53dcc7435e43" - "Nf14F/Arg681*": - description: "Cre-negative Nf14F/Arg681*" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2a0345f-f0ba-4d72-99d7-f9ad2ea77751" - "Nf14F/Arg681*;CAGGCre-ERTM": - description: "[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e70947db-35d1-448b-90d8-ec6f14e70303" + description: C57BL/6J mice with a targeted NF1 gene disruption mutation at + exon 31 to mimic human NF1 mutations, knockout mutation of Nfl + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e104ac3-b954-4afa-8d87-60c3b1d80b73 + Nf1-/- Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=500a5c2f-5104-405e-a243-3d85b59d6b08 + Nf1-/-MyoD: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02afeba7-05c6-48b1-9454-efe73d9b21f2 Nf1:p53: - description: "Nf1:p53 mouse tumor model" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8500990a-8848-413c-9c5b-7697d697fa2e" - "Nf1Dsk9/+": - description: "Maintained on a mixed (C3HeB/FeJ x C57bl/6) background" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45756c39-61e8-48b6-ab0c-8f9ce9ad668a" - "Nf1E1 Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=52351388-ba1f-4cf8-a03a-23b941d4408e" + description: Nf1:p53 mouse tumor model + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8500990a-8848-413c-9c5b-7697d697fa2e + Nf1+/- P53+/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9194d4de-84b2-438a-af6e-6cdfe79ff8cb + Nf1+/-x129S2/SvHsd: + description: one nf1 allele is deleted + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed66f5fd-52fd-4e83-8442-90b0676cf694 + Nf1+/Arg681: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118cc6d8-b656-4d6a-9cff-83f2ad92e2b0 + Nf1+/ex42del pig: + description: heterozygotic mutation in NF1 (exon 42 deletion) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57625a6e-c039-418e-8e22-db464f8aa827 + Nf1+/R681X: + description: harbored a NF1-patient-derived Nf1 gene mutation (c.2041C>T;p.R681X) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8b964052-b74b-4ca3-ad82-31bd2f3457aa + Nf14F/4F; DhhCre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb4aff73-9da2-42b5-8f94-0a6084db75b0 + Nf1+/Δ4: + description: Heterozygous mice harboring a null allele resulting from exon + 4 deletion + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3013cfbf-07fd-448e-8c57-cf25223eb0b4 + Nf14F/Arg681*: + description: Cre-negative Nf14F/Arg681* + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2a0345f-f0ba-4d72-99d7-f9ad2ea77751 + Nf1a+/-; Nf1b-/-; p53m/m zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9cf037b-1743-4eef-88ff-8a80659323eb + Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3a1e3de-577d-4b4b-9eed-91dc21c1bbde + Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=757bf9d9-cf3c-400e-b470-d65302d22897 + Nf1adelta8 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=89b2f63c-1538-468e-9ca1-7ff948cb354e + Nf1aL1247X zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cbc2b84-509f-44c6-b4f2-b77731ca34ef + Nf1bdelta55 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3853fe16-e6fe-4520-8e53-9845c1679fbf + Nf1Dsk9/+: + description: Maintained on a mixed (C3HeB/FeJ x C57bl/6) background + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45756c39-61e8-48b6-ab0c-8f9ce9ad668a + Nf1E1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=52351388-ba1f-4cf8-a03a-23b941d4408e Nf1Fcr: - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05c510fc-2ffc-457f-ba62-679c91799800" - "Nf1Gly848Arg/Gly848Arg": - description: "Homozygous for missense c.2542G>C; p.Gly848Arg mutation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4dfc91c9-31f4-4b00-a95e-4f1b26307339" - "Nf1P1 Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc95a39a-5f41-4d34-9c0c-f312028aa2f3" - "Nf1P1/Nf1E1 Drosophila": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=326557dc-c320-4f04-b64a-08edd703ee95" - "Nf1Prx1-/-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a66bcb2-e137-4471-8cee-29dd9655b276" - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=757bf9d9-cf3c-400e-b470-d65302d22897" - "Nf1a+/-; Nf1b-/-; p53m/m zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9cf037b-1743-4eef-88ff-8a80659323eb" - "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3a1e3de-577d-4b4b-9eed-91dc21c1bbde" - "Nf1aL1247X zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cbc2b84-509f-44c6-b4f2-b77731ca34ef" - "Nf1adelta5 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e7a8732a-73ba-4d05-88a9-8d796d0f1a6b" - "Nf1adelta8 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=89b2f63c-1538-468e-9ca1-7ff948cb354e" - "Nf1b+10 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d5e90cc-e97a-4321-b0a5-82feed840c50" - "Nf1bdelta55 zebrafish": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3853fe16-e6fe-4520-8e53-9845c1679fbf" - "Nf1flox/+;P0A-Cre(+)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ed9ea80-e1fe-4224-bd67-594d9d0b0c7e" - "Nf1flox/-": - description: "Nf1+/- mouse" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbeb0bb9-5341-496c-991a-de1e84af09b5" - "Nf1flox/-; GFAP-Cre; CD11b-TK": - description: "Optic glioma mice with monocyte thymidine kinase expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d1c0c790-acff-486a-b794-b0429b09eeec" - "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp": - description: "Optic glioma mice with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e487fd33-48d3-4a02-b2e0-4d0525ee8e20" - "Nf1flox/-;Col2.3Cre(+)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9d41a9c-d779-4a05-b848-440287fa8b6b" - "Nf1flox/-;Cx3cr1+/gfp": - description: "Nf1+/- mouse with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a2a52f7-e0e2-4654-9157-07848c8b0bcc" - "Nf1flox/-;Krox20-Cre": - description: "peripheral nerves contain -/- Schwann cells and +/- mast cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46fb4411-d129-488c-83a5-c8e20176018e" - "Nf1flox/-;P0A-Cre-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=645fbd19-84c3-470e-bbf0-3cce94f0e6c9" - "Nf1flox/-;hGFAP-Cre": - description: "[From GFF:] Mice heterozygous for a germ-line Ex31-32 Nf1 mutation and a conditional knock-out of NF1 in astrocytes" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbf11ec4-1d12-4feb-a6fc-9faf6bc9c9db" - "Nf1flox/flox; NG2-Cre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2d103d-0d76-49aa-bf20-a17318184341" - "Nf1flox/flox;Cx3cr1+/gfp": - description: "wild-type mouse with reduced Cx3cr1 expression" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e71b421a-5e1d-49d6-a045-aa03aff7e7fe" - "Nf1flox/flox;Islet1-Cre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe8bd0a-f95f-46d5-b451-731c9155520b" - "Nf1flox/flox;Krox20-Cre": - description: "peripheral nerves contain -/- Schwann cells and +/+ mast cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=441ea70d-e784-4fc0-a080-50e07acf5f05" - "Nf1flox/flox;P0A-cre-": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c1518d2-ea81-4cfc-bd3c-e3a6067053b1" - "Nf1flox/flox;PostnCre(+)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=215b4e43-8a99-4702-ab4b-eeeadeeb13a5" - "Nf1flox/flox;Rac1flox/+;PostnCre(+)": - description: "Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59c9a1fc-9754-40b3-8169-c2185b522a75" - "Nf1flox/floxRac1flox/flox;PostnCre(+)": - description: "Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3ae87c9-2734-4809-a08a-9212cf278437" - "Nf1flox/mut": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ff3a2b6-110b-4352-8abf-74b46c7e55ce" - "Nf1flox/mut; GFAP-Cre": - description: "NF1 conditional knock out" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4e513b5b-dde9-424d-96ff-3dd7c90f429b" - "Nf1flox/mut; NG2-Cre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=669641d6-2e7c-4679-bfe8-0d31c53c2dfc" - "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=92a431bb-182a-4f6a-92a5-4509888e2102" - Nf1pArg1947mp1: - description: "[From GFF:] Minipig model containing a recurrent nonsense mutation p.Arg1947*(R1947*) and HindIII RFLP site resulting in frame shift mutation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=209c16d7-c1fa-414f-8f08-458eaefc2259" - Nf1tm1.1Kest: - description: "[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) was introduced in exon 18 and a FRT-flanked neomycin selection cassette was inserted in intron 17. Flp-mediated recombination removed the selection cassette." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504d7dfe-acf9-476c-974d-e8665095afbb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05c510fc-2ffc-457f-ba62-679c91799800 + Nf1flox/-; GFAP-Cre; CD11b-TK: + description: Optic glioma mice with monocyte thymidine kinase expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d1c0c790-acff-486a-b794-b0429b09eeec + Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp: + description: Optic glioma mice with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e487fd33-48d3-4a02-b2e0-4d0525ee8e20 + Nf1flox/-;Col2.3Cre(+): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9d41a9c-d779-4a05-b848-440287fa8b6b + Nf1flox/-;Cx3cr1+/gfp: + description: Nf1+/- mouse with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a2a52f7-e0e2-4654-9157-07848c8b0bcc + Nf1flox/-;Krox20-Cre: + description: peripheral nerves contain -/- Schwann cells and +/- mast cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46fb4411-d129-488c-83a5-c8e20176018e + Nf1flox/-;P0A-Cre-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=645fbd19-84c3-470e-bbf0-3cce94f0e6c9 + Nf1flox/+;P0A-Cre(+): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ed9ea80-e1fe-4224-bd67-594d9d0b0c7e + Nf1flox/flox; NG2-Cre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2d103d-0d76-49aa-bf20-a17318184341 + Nf1flox/flox;Cx3cr1+/gfp: + description: wild-type mouse with reduced Cx3cr1 expression + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e71b421a-5e1d-49d6-a045-aa03aff7e7fe + Nf1flox/flox;Islet1-Cre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe8bd0a-f95f-46d5-b451-731c9155520b + Nf1flox/flox;Krox20-Cre: + description: peripheral nerves contain -/- Schwann cells and +/+ mast cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=441ea70d-e784-4fc0-a080-50e07acf5f05 + Nf1flox/flox;P0A-cre-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c1518d2-ea81-4cfc-bd3c-e3a6067053b1 + Nf1flox/flox;PostnCre(+): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=215b4e43-8a99-4702-ab4b-eeeadeeb13a5 + Nf1flox/flox;Rac1flox/+;PostnCre(+): + description: Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59c9a1fc-9754-40b3-8169-c2185b522a75 + Nf1flox/floxRac1flox/flox;PostnCre(+): + description: Generated by breeding Rac1flox/flox mice (129SV background) with Nf1flox/flox;PostnCre+ mice + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3ae87c9-2734-4809-a08a-9212cf278437 + Nf1flox/mut: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ff3a2b6-110b-4352-8abf-74b46c7e55ce + Nf1flox/mut; NG2-Cre: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=669641d6-2e7c-4679-bfe8-0d31c53c2dfc + Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC): + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=92a431bb-182a-4f6a-92a5-4509888e2102 + Nf1Gly848Arg/Gly848Arg: + description: Homozygous for missense c.2542G>C; p.Gly848Arg mutation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4dfc91c9-31f4-4b00-a95e-4f1b26307339 + Dhh-Cre; Nf1flox/+; Ptenflox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d50930bc-c261-41a6-b517-548516044526 + Nf1 Ocl-/-: + description: Nf1-deficient osteoclasts in otherwise Nf1+/+ background + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09880210-fe90-4af9-8b1f-f886348a34eb + Nf1P1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc95a39a-5f41-4d34-9c0c-f312028aa2f3 + Nf1Prx1-/-: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a66bcb2-e137-4471-8cee-29dd9655b276 Nf1tm1a(KOMP)Wtsi: - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85b32836-b4c6-4f72-b0d5-a9f192fe2806" - Nf1tm1c(KOMP)Wtsi: - description: "[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A \"conditional ready\" (floxed) allele was created by flp recombinase expression in mice carrying this allele." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=361988eb-d390-4f40-b01b-acee637e2271" - Nf1tm1d(KOMP)Wtsi: - description: "[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A \"conditional ready\" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ecabd72-d36c-487e-8c0e-c05e3dd743ba" - Nf1tm2.1Kest: - description: "[From GFF:]  A point mutation, recapitulating the human missense variant c.2542G>C, in which a glycine residue at position 848 was changed to an arginine (p.Gly848Arg), was introduced in exon 21 and a FRT-flanked neomycin selection cassette was inserted in intron 20. Flp-mediated recombination removed the selection cassette." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e5c372e-dec8-4693-98a8-b07f3014257d" - "P0-GGFb3": - description: "overexpress the growth factor neuregulin-1 in Schwann cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57d32b42-8034-4ea4-a14b-78f285eed3c8" - "PlpCre;Nf1flox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5359b57-3b0a-460d-900b-dbd7cc2af7d3" - "PlpCreERT; Nf1flox/flox; eGFP": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b0b57e3-bc2d-4f0a-b42f-213be95ce457" - "Prx1-Cre+/- Nf1flox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be5c22d-862e-4739-a214-89546880a840" - "Prx1-Cre+/- Nf1flox/flox": - description: "homozygous knockout" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b0e4be7c-1b0f-4564-aa18-05b36ac77055" - "Spred1+/-": - description: "Heterozygous loss-of-function SPRED1 mutation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a8c3628-fce7-4219-825b-5551f223754d" - "Spred1-/-": - description: "SPRED1 knock-out" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4f433c0f-2c9b-41f7-9b04-ff32f524b55b" - "dNf1 Drosophila": - description: "Homozygous dNf1 null mutants" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7b76ccd-e646-4d30-8868-ba39541dd573" - "delta-ira1 delta-ira2 yeast": - description: "delta-ira1 delta-ira2 double-knockout yeast" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b2a7ee1-e462-42b9-80b8-0a64ca60b091" - "miR-155 +/-;Nf1flox/+": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2470d9dd-b6c8-4cdb-ad2e-009071477c41" - "miR-155 +/-;Nf1flox/+;DhhCre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a79e9847-1e32-41c8-a176-adf96a8547c0" - "miR-155 -/-;Nf1flox/flox ;DhhCre": - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6e61b912-8006-48cb-a122-df613c8921c4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85b32836-b4c6-4f72-b0d5-a9f192fe2806 + CAMK2-CreTg/+ ; flox-NrasG12VTg/+: + description: Transgenic mouse expressing oncogenic N-ras specifically in central + nerve cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06545c3d-e098-4a67-a678-6f023fda6b88 + P0-GGFb3: + description: overexpress the growth factor neuregulin-1 in Schwann cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57d32b42-8034-4ea4-a14b-78f285eed3c8 + PlpCre;Nf1flox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5359b57-3b0a-460d-900b-dbd7cc2af7d3 + PlpCreERT; Nf1flox/flox; eGFP: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b0b57e3-bc2d-4f0a-b42f-213be95ce457 + Prx1-Cre+/- Nf1flox/+: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be5c22d-862e-4739-a214-89546880a840 + Prx1-Cre+/- Nf1flox/flox: + description: homozygous knockout + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b0e4be7c-1b0f-4564-aa18-05b36ac77055 + Spred1-/-: + description: SPRED1 knock-out + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4f433c0f-2c9b-41f7-9b04-ff32f524b55b + Spred1+/-: + description: Heterozygous loss-of-function SPRED1 mutation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a8c3628-fce7-4219-825b-5551f223754d + Nf1 Arg681*/Arg681*: + description: Created by breeding Nf1 +/Arg681* (Nf1tm1.1Kest), is embryonic + lethal at day 9.5. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91e9130d-00bc-4dfe-9a5d-356e5ae3f4db + Nf1 Δ4/Δ4: + description: Created by breeding Nf1 +/Δ4, is embryonic lethal at day 9.5. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8984594-d5ff-4827-8e83-13ccbf0055e8 + Nf1 +/Δ4: + description: Mice harboring a null allele resulting from exon 4 deletion were + created by breeding Nf1+/4F mice to an EIIaCre driver line (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9933922-29fb-4a4c-bc5f-604691a8bab7 + B6.FVB-Tg(EIIa-cre)C5379Lmgd/J: + description: EllaCre driver line. + meaning: rrid:IMSR_JAX:003724 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5511a019-88aa-43c8-86c3-ad1677c8a3d0 diff --git a/modules/Sample/CellLineCategory.yaml b/modules/Sample/CellLineCategory.yaml new file mode 100644 index 00000000..a43f86d1 --- /dev/null +++ b/modules/Sample/CellLineCategory.yaml @@ -0,0 +1,24 @@ +enums: + CellLineCategoryEnum: + description: Category of cell line based on origin and characteristics + permissible_values: + Cancer cell line: + description: Cell line derived from cancer/tumor tissue + Induced pluripotent stem cell: + description: Pluripotent stem cells generated from somatic cells through reprogramming + Transformed cell line: + description: Cell line transformed by viral or chemical agents + Telomerase immortalized cell line: + description: Cell line immortalized through telomerase expression + Embryonic stem cell: + description: Pluripotent stem cell derived from embryonic tissue + Finite cell line: + description: Cell line with limited passage potential + Hybrid cell line: + description: Cell line created by fusion of two different cell types + Hybridoma: + description: Hybrid cell line formed by fusion of antibody-producing cells with myeloma cells + Spontaneously immortalized cell line: + description: Cell line that spontaneously acquired immortalization + Undefined cell line type: + description: Cell line with unspecified or unknown category diff --git a/modules/Sample/CellLineGeneticDisorder.yaml b/modules/Sample/CellLineGeneticDisorder.yaml new file mode 100644 index 00000000..c39b660c --- /dev/null +++ b/modules/Sample/CellLineGeneticDisorder.yaml @@ -0,0 +1,14 @@ +enums: + CellLineGeneticDisorderEnum: + description: Genetic disorder associated with the cell line + permissible_values: + Neurofibromatosis type 1: + description: Cell line derived from or associated with NF1 + Neurofibromatosis type 2: + description: Cell line derived from or associated with NF2 + Schwannomatosis: + description: Cell line derived from or associated with schwannomatosis + Noonan Syndrome: + description: Cell line derived from or associated with Noonan Syndrome + No known genetic disorder: + description: Cell line with no known associated genetic disorder diff --git a/modules/Sample/CellLineModel.yaml b/modules/Sample/CellLineModel.yaml index f69877af..ff97c20e 100644 --- a/modules/Sample/CellLineModel.yaml +++ b/modules/Sample/CellLineModel.yaml @@ -1,2266 +1,2592 @@ -# WARNING: This file is auto-generated from Synapse table syn26450069 +# WARNING: This file is auto-generated from Synapse table syn51730943 # DO NOT EDIT DIRECTLY - changes will be overwritten # For manual entries, use the corresponding *Manual.yaml file -# Generated by utils/sync_model_systems.py +# Generated by utils/sync_model_systems_enhanced.py enums: CellLineModel: permissible_values: - "10/9CRC1": - meaning: rrid:CVCL_8478 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25c617df-ff54-4ba5-b293-d9fcc9be39ce" - 10CM: - description: "Mutation of NF1, p.Arg440Ter (c.1318C>T), Unspecified zygosity (PubMed=26744134). Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26744134)." - meaning: rrid:CVCL_VJ83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423cc0f3-8a43-4e10-a9a4-d529aa78f022" - '1507.2': - meaning: rrid:CVCL_1Y71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4304050f-f24a-45b9-9025-8e3e88d0b377" - "2-004": - description: "Patient-derived cell line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b44907f-47e9-470f-918e-03e55cc9eff9" + HEK293 NF1 -/- with R1306X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R1306X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02dacc42-ea46-48fb-a4df-7a875d801086 + SZ-NF4: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_YL59 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09c988ab-765a-44ca-b2d7-1957b729208e + HBE135-E6E7: + description: '[From ATCC:] The HBE135-E6E7 cell line was derived from normal + bronchial epithelium taken from a man undergoing lobectomy for squamous + cell carcinoma. Cells from the primary explant in their first passage were + infected with the recombinant retrovirus LXSN16E6E7 containing the human + papilloma virus (HPV) E6E7 gene.' + meaning: rrid:CVCL_3695 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a1a3741-0337-4067-95ab-fb0dc9562d66 + 90-8: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_1B47 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f404e70-2acf-4877-bcd5-6da81d9fa41e + WT ES: + description: '[From GFF:] WT ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1097f821-56c3-4e51-bcd3-f84aef506e3a + 'HEK293 NF1 -/- Exon 47 insT #14': + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- Exon 47 insT #14' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=130fd347-28e1-46c2-a72d-d243e99322b7 + hTERT SC ipn97.4: + description: Healthy Schwann cells. + meaning: rrid:CVCL_UI66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13ae2445-21e3-4b75-ae70-317a3d5ee40c + HEK293 NF1 -/- with R1947X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R1947X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14353c91-2be9-4617-b337-c29080961826 + Nf1-/- skin-derived precursor cells: + description: '[From GFF:] Nf1-/- skin-derived precursor cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=15c3bd82-9791-4a53-b6f7-4d23b882a285 + KCL025: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_A258 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=18ba4c2e-e8d5-4032-a6ab-d0fca3f0f984 + NF1: + description: Cell line from an NF1 patient; unclear if derived from tumor + or non-tumor tissue. + meaning: rrid:CVCL_JG80 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a8a362e-e3be-4bc3-be7e-d0a0865b9c31 + Dhh-Cre; NF1Arg681*/flox Schwann Cells: + description: '[From GFF:] Dhh-Cre; NF1Arg681*/flox Schwann Cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae5651a-818f-4732-8045-17bea2555056 + NCC-MPNST3-X2-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU15 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b604846-d41c-4969-a79a-9660c04e585c + 3PNF_SiPSsv_MM_11: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cc872fc-6a95-4722-a598-bf60bb124b82 + ST88-14: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_8916 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=202c110b-a5f1-49ab-acdc-e6e33a1c29bb + 'Schwann cell NF1 -/- (iPN97.4 #24)': + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- (iPN97.4 #24)' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=234515dd-7c28-4172-83c7-59dddfa22acb + HeLa SilenciX NF1: + description: HeLa cervical cancer cells with stable (EBV-based siRNA) knockdown + of the NF1 gene. + meaning: rrid:CVCL_KT82 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2549e536-b033-43e4-acf6-501499b6e498 + hTERT NF1 ipnNF95.11c: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 + patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI69 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c4c8b02-f12e-4a17-a408-38ae88dd841d + ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. ELK-TAD + Luciferase Reporter HEK293 Stable NF1 -/-' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3239573e-4ae1-4e01-8098-00dce6ac0a84 + HEK293 NF1 -/- with R681X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R681X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=32f73d96-fd2a-4966-a150-ba5fa47d150c + SZ-NF1: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_YL57 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=33cdb482-618e-4489-87d9-3139cc7c6a49 + Schwann cell NF1 -/- with R816X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- with R816X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a3e5460-3d5b-45f9-995d-25bd49c06f34 + hTERT ipn02.3 2λ: + description: Derived from peripheral sciatic nerve from a donor without neurofibromatosis. + No detectable NF1 mutation. + meaning: rrid:CVCL_UI64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a507bfd-7d2b-4238-b79a-83fe985c2cea + hTERT ipn02.8: + description: Derived from peripheral nerve from a donor without neurofibromatosis. + No detectable NF1 mutation. + meaning: rrid:CVCL_UI65 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a8f5be4-aa22-48f2-9a76-9412010ecd45 + Schwann cell NF1 -/- with WT tagged mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- with WT tagged mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3beebac1-95b0-4834-9008-19f7d268fc5b + hTERT NF1 ipn06.2 A: + description: Derived from a pleural plexiform neurofibroma. + meaning: rrid:CVCL_UI74 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dedf9d2-614c-4cf9-8d18-aff8aa2dc0eb + HEK293 NF1 -/- with R461X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R461X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f29aa26-1d05-453a-a6ac-d4e37d609dba + Nf1-/- HEK 293: + description: '[From GFF:] Nf1-/- HEK 293' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=44f9c496-ddd8-4e4b-bddb-6b93f7e04fc2 + icNF98.4c: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF98.4c). + meaning: rrid:CVCL_B9V7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46da7a41-c654-426e-bfb7-361caf4d3c4c + Nf1Arg681*/Arg681* MEFs: + description: '[From GFF:] Nf1Arg681*/Arg681* MEFs' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47f50ef0-8d59-430d-9d05-7df1a4f41c3b + GM23338: + description: '[From GFF:] iPSC NF1 WT, PGP1 cells' + meaning: rrid:CVCL_F182 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c4e4b03-5975-4708-a25c-f6c45cbe3abf + iPSC NF1 WT: + description: '[From GFF:] iPSC NF1 WT BJFF.6 bkgd' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4cf14492-2735-4e31-ab6a-75554b9ad298 + sNF94.3: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K164 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504647eb-6b60-492a-bb51-3ab025830f51 + hTERT NF1 ipNF05.5: + description: Derived from a plexiform neurofibroma growing on a hand. + meaning: rrid:CVCL_UI71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5502caf5-4cf1-418f-bf50-164cfa316b0f 28cNF: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (i28NF)." + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (i28NF). meaning: rrid:CVCL_B9V9 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a466cdc-5eaa-45a5-87b1-ba9cac6d7d21" - 2XSB: - meaning: rrid:CVCL_A7NI - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f4e4596-0c7d-4d41-b9ff-73ecebd30263" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a466cdc-5eaa-45a5-87b1-ba9cac6d7d21 + YST-1: + description: Schwannoma cell line, potentially mischaracterized in some cases + as a sporadic MPNST cell line. + meaning: rrid:CVCL_5192 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=617cb183-3377-4473-8ad8-2f6472bce1fa + T265: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_S805 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6419dd0d-1937-4ecf-bf01-876632ae0f54 + Dh5 alpha: + description: '[From GFF:] Dh5 alpha' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=68977077-e0a3-40df-92ab-d62285edd23c + Nf1Arg681*/+ ES: + description: '[From GFF:] Nf1Arg681*/+ ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ff97eee-5c1a-4439-9df6-d1715cbdd189 + Nf1Arg681*/Arg681* ES: + description: '[From GFF:] Nf1Arg681*/Arg681* ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=70c1e3f6-751f-49e4-aa47-e3bea4aeac43 + icNF04.9a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF04.9a). + meaning: rrid:CVCL_B9VC + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=75d4b88a-a906-4f08-a9f8-66490328b9f1 + Nf1-/- Epithelial lung cells: + description: '[From GFF:] Nf1-/- Epithelial lung cells, derived from HBE135-E6E7 + epithelial lung cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=779714c8-f522-4355-a502-d5d2e6e09afa + HEK293: + description: '[From ATCC:] This is a hypotriploid human cell line.' + meaning: rrid:CVCL_0045 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7b6dcc42-3c32-4008-8b2c-309aa01b17be + 'HEK293 NF1 -/- Exon 52 R2550X #5': + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- Exon 52 R2550X #5' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d565aea-0917-428b-9101-d2a19f3fbcf1 3PNF_FiPSsv_PM_2: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. meaning: rrid:CVCL_UN11 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7deb7765-38aa-4d8a-a3cb-bd4aefeb3a86" - 3PNF_SiPSsv_MM_11: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." - meaning: rrid:CVCL_UN12 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cc872fc-6a95-4722-a598-bf60bb124b82" - "4/30PRR": - meaning: rrid:CVCL_8480 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0aed5bf6-d5e2-4a6d-ac3b-a51b5e8bbb8b" - 5PNF_TDiPSsv_MM_4: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." - meaning: rrid:CVCL_UN13 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db6b3d0d-ee80-49ab-bb51-5672448e580b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7deb7765-38aa-4d8a-a3cb-bd4aefeb3a86 + icNF00.10a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF00.10a). + meaning: rrid:CVCL_B9V0 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ef2fd6f-9ba6-4e30-94fc-d4ffd61de6e6 + NCC-MPNST3-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU14 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7fe31236-bc93-449b-b559-9394999be926 + NCC-MPNST5-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU17 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=827f08a1-3d0f-4fd8-98e4-fb5c40a9c742 + hTERT NF1 ipNF05.5 (Mixed clones): + description: Derived from a plexiform neurofibroma growing on a hand. + meaning: rrid:CVCL_UI72 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844b598c-0171-4972-91c3-27aa21b45d52 + cNF98.4d: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF98.4d). + meaning: rrid:CVCL_B9V6 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=882101e0-1207-4323-a354-6d5a642e6ca3 + BJFF.6: + description: iPSCs created with foreskin fibroblasts. + meaning: rrid:CVCL_VU02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8a213a9d-392b-4746-8f59-c12f753d9217 + hTERT NF1 ipnNF09.4: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 + patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI73 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e0602ff-e3e6-438e-9fb7-c7abc1dd4304 + i28cNF: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (28NF). + meaning: rrid:CVCL_B9VA + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e9ec3f3-5622-4f8f-a02c-34d8777c82b6 5PNF_TDiPSsv_PM_6: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. meaning: rrid:CVCL_UN14 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ebe9be8-88df-4598-bd25-510de550ca5e" - 6PNF_SiPSrv_PM_2: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." - meaning: rrid:CVCL_UN15 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4deb9a8-7929-44f2-974d-375771b8c681" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ebe9be8-88df-4598-bd25-510de550ca5e + NCC-MPNST2-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU13 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f646e44-5263-4f80-bb94-b297a875c52a + hTERT NF1 ipNF04.4: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI78 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fdc5f7a-ef8c-4193-a5c0-04577c3b134d + NF1-R68X Embryonic cells: + description: '[From GFF:] NF1-R68X Embryonic cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90748442-be62-44f1-899e-804cd5600823 7PNF_SiPSrv_PM_12: - description: "Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank." + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. meaning: rrid:CVCL_UN16 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95997768-950e-4c8d-93bb-e6ed370e503f" - 862L: - meaning: rrid:CVCL_8477 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6faf7e00-d770-4527-9384-539f6db31977" - "9/3L": - meaning: rrid:CVCL_8479 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c98ce5c-5cf1-4829-943d-5142073583d8" - "90-8": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_1B47 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f404e70-2acf-4877-bcd5-6da81d9fa41e" - A68: - description: "From a surgically excised pNF specimen of a 51-year-old female with NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=328fd785-453d-4a09-be93-b7da67d9d33e" - "AMC-106": - meaning: rrid:CVCL_9477 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf77b1e3-93be-4b4e-bc34-85d8b9d06a81" - "Abcam A-549 NF1 KO": - description: "Mutation of KRAS, p.Gly12Ser (c.34G>A), Homozygous (from parent cell line)." - meaning: rrid:CVCL_B9NJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d605ae2e-969a-4956-bac5-5e36654d7b41" - "Abcam HCT 116 NF1 KO": - description: "Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (from parent cell line)." - meaning: rrid:CVCL_B8LD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5ec9375-0564-414a-94ad-86d5083b440f" - "Abcam HeLa NF1 KO": - description: "Nf1 knockout cell" - meaning: rrid:CVCL_B1YJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b26e0c8b-689f-4018-bf27-e2d3a522e039" - "Abcam MCF-7 NF1 KO": - description: "Nf1 knockout cell" - meaning: rrid:CVCL_B8ZE - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24719e11-8ac2-452c-9424-20d75fc26d82" - "Abcam U-87MG SNCA KO": - description: "Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)." - meaning: rrid:CVCL_C0BJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5f5d4a-95f7-4e5c-9db1-d13fbc9748a7" - "AsPC-1": - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=15367885, PubMed=21607521, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0152 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bbfd278-a1aa-4279-b648-94efe9e1f242" - BJFF.6: - description: "iPSCs created with foreskin fibroblasts." - meaning: rrid:CVCL_VU02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8a213a9d-392b-4746-8f59-c12f753d9217" - "BTSC 232": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4d9d286-d169-41d0-8dc8-45bc92984aaf" - "BTSC 233": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b664f320-dd73-4aae-82e7-91c42b48744a" - "BTSC 3021": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f98c4bb5-b168-431a-8642-f769bed673a3" - "BTSC 3047": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=852b8fa5-892d-4353-9d6b-4673396ca999" - "BTSC 349": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ea69fa4e-4393-4ffe-a5a8-f4df59789813" - "BTSC 380": - description: "Human patient-derived brain tumor stem cell lines (BTSCs)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98790fc2-9cdf-442c-94d2-e6775cfb8ad3" - "BayGenomics ES cell line XF344": - description: "Nf1 knockout cell" - meaning: rrid:CVCL_PR85 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=60633d59-0230-47c3-9d40-08b0ae194b6d" - "CFPAC-1": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=11169959, PubMed=11787853, PubMed=15367885, Cosmic-CLP)." - meaning: rrid:CVCL_1119 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6f287de-eadb-4020-be7a-5b761172fec6" - "CML-6M": - description: "Pigmented. Mutation of NF1, p.Pro1599fs (c.4795delCinsTT), Heterozygous (PubMed=31175136)." - meaning: rrid:CVCL_0D24 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=acd954de-1f36-41ad-8ce0-ac738aa840ba" - "COLO 668": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1128 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a57bc0e-51ee-4a44-a872-2ed8ab56f4c6" - "COR-L23": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1139 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6928d53-c913-4078-8354-4a5de3d5c824" - "CPTC-NF1-1": - meaning: rrid:CVCL_C2NU - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65d07476-2469-4679-85b2-e2ca67f3b01b" - "CPTC-NF1-2": - meaning: rrid:CVCL_C2NV - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f410431d-7571-4302-8870-eb115b71d0ce" - "CPTC-NF1-3": - meaning: rrid:CVCL_C2NW - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42257ac4-1950-4541-9bee-b9a965e2fa86" - "CTV-1": - description: "Mutation of NF1, p.Gly1532Arg (c.4594G>A), Heterozygous (PubMed=22675565, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1150 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37cbf7b9-f74c-4407-8541-86c17e394c5d" - "Calu-1": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=12794755, DepMap)." - meaning: rrid:CVCL_0608 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=055e78dc-b3d2-416b-a7f1-ac4de9d9ec2b" - "Capan-1": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=8026879, PubMed=8426738, PubMed=15367885, PubMed=21750719, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0237 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efe31e45-2075-4b41-a06f-a1d5935622fa" - "Capan-2": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=7961102, PubMed=8026879, PubMed=8426738, PubMed=11169959, PubMed=15367885, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0026 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a32eaaa-e7cf-45a2-ae52-528a09eea541" - "D-566MG": - description: "Mutation of NF1, p.Ile941Serfs*13 (c.2820delC), Heterozygous (Cosmic-CLP)." - meaning: rrid:CVCL_1166 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc7c0fee-8a89-49a2-b58c-eff50448006d" - "DAN-G": - description: "2 alleles of G12V mutation in KRAS gene. Established from a xenograft produced by implantation of cells from the tumor of a patient with cancer of the pancreas in a nude mouse (CLS). Mutation of KRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (CLS, Cosmic-CLP)." - meaning: rrid:CVCL_0243 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=99359d65-6e01-410d-be59-217aa0bfb9c9" - DD2345: - description: "An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line" - meaning: rrid:CVCL_9J79 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2e792f78-55b0-4091-9f86-6b78abd920bb" - "Dh5 alpha": - description: "[From GFF:] Dh5 alpha" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=68977077-e0a3-40df-92ab-d62285edd23c" - "Dhh-Cre; NF1Arg681*/flox Schwann Cells": - description: "[From GFF:] Dhh-Cre; NF1Arg681*/flox Schwann Cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae5651a-818f-4732-8045-17bea2555056" - "ELK-TAD Luciferase Reporter HEK293 Stable": - description: "[From GFF:] ELK-TAD Luciferase Reporter HEK293 Stable" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c88fcbc9-24c1-4f2b-8d13-02f5037dcf1c" - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3239573e-4ae1-4e01-8098-00dce6ac0a84" - "FMS-1": - meaning: rrid:CVCL_IS33 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b14a6ae1-829c-4ae3-9149-9fcf6cc6c57d" - "FTC-133": - description: "Has a near-homozygous genome (NHG). Mutation of NF1, p.Cys167Ter (c.501T>A), Homozygous (PubMed=30737244)." - meaning: rrid:CVCL_1219 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a630172-cf98-41c1-ae06-c436900fb513" - "FU-SFT8710": - meaning: rrid:CVCL_ZE77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b96c1fa0-5284-424a-b29e-338db3c8b292" - "GI-ME-N": - description: "Gene deletion, NF1, Heterozygous (PubMed=20655465). Mutation of NF1, Microdeletion, Heterozygous (PubMed=20655465)." - meaning: rrid:CVCL_1232 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe5b49ff-6d77-4de3-adc3-0fc97fd076e4" - "GI-ME-NrCDDP500": - description: "Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line)." - meaning: rrid:CVCL_RS22 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=73b8caeb-cc91-4d81-b076-25d611949807" - "GI-ME-NrDOX5": - description: "Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line)." - meaning: rrid:CVCL_RS07 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a03250ca-0914-4318-b5c6-5b5a86ca1965" - "GI-ME-NrVCR14": - description: "Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line)." - meaning: rrid:CVCL_RR32 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25fa8030-970e-48ec-8e22-55e23a747164" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95997768-950e-4c8d-93bb-e6ed370e503f + HEK293 NF1 -/- with WT tagged mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with WT tagged mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96d339f9-9d19-40c3-8f81-3590f7c00205 + hTERT NF1 sipnNF95.12B: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 + patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI75 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98beda5b-9b28-4119-829a-2a0219d77af7 + STS-26T: + description: Sporadic MPNST tumor cell line from a non-NF1 patient. + meaning: rrid:CVCL_8917 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9a7997c9-9399-47ed-b44b-5b717be89ba3 + 'HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice': + description: '[From GFF:] HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b4b8eca-f981-440d-b478-0a5483353368 + iPSC NF1 +/- BJFF.6 bkgd: + description: '[From GFF:] iPSC NF1 +/- BJFF.6 bkgd' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0c91627-fad6-4d60-bf74-67623374eff8 + GM11601: + description: Leukemia cell line derived from B-lymphocytes from an NF1 patient. + meaning: rrid:CVCL_AA01 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2f62c57-a1b8-4867-9c91-04406f261cfa + icNF97.2a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF97.2a). + meaning: rrid:CVCL_B9V3 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a731535e-f7a6-4c6e-b0db-7f0d0979e69f + hTERT NF1 ipNF00.6: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI76 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8f48ce7-438c-4564-a70b-020abc96d5fe + HEK293 NF1 -/- with R2550X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R2550X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aa32fc67-9cc3-4d31-bcbd-f7044f9fd484 + hTERT NF1 ipNF95.11b C/T: + description: Derived from a plexiform neurofibroma growing on a brachial plexus. + meaning: rrid:CVCL_UI68 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ab60aae5-7860-4d1d-bb02-208e6631c78b + cNF00.10a: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF00.10a). + meaning: rrid:CVCL_B9UZ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad2e271b-55ac-44ae-b39d-f1a6d76e1dc3 + iPSC Y489C; Exon 13 cryptic splice: + description: '[From GFF:] iPSC Y489C; Exon 13 cryptic splice, PGP1 cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad73cdb2-8add-48ff-b9f2-35a38132db84 + 'HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice': + description: '[From GFF:] HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae765b00-9189-4a72-8ae7-cddc41e24055 + S462: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_1Y70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2fb9f7e-ea11-404f-8c0c-c9dc36367f2d + hTERT NF1 ipNF95.6: + description: Derived from a plexiform neurofibroma growing on cranial nerve + XII. + meaning: rrid:CVCL_UI70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b44361f2-9021-4920-901a-b1a1f9143f97 + cNF97.2b: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF97.2b). + meaning: rrid:CVCL_B9V2 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4987f0a-67ec-4f13-96f1-9443aac6e5ac + sNF02.2: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K280 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b72d99fd-ee1e-42ec-92b6-9f89e375cce1 + ScienCell Schwann cells: + description: '[From ScienCell:] HSC from ScienCell Research Laboratories are + isolated from human spinal nerve. (editorial note: these cells likely come + from multiple donors)' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b751b5d4-56e6-42a2-a2dc-289f90c6dd82 + icNF98.4d: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF98.4d) + meaning: rrid:CVCL_B9V8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd74fd9f-6357-40d5-8569-96883628fb1a + hTERT NF1 ipNF95.11b C: + description: Derived from a plexiform neurofibroma growing on a brachial plexus. + meaning: rrid:CVCL_UI67 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be2333d6-6716-4d13-947d-41f4198497a4 + S520: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_AX35 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0a60dec-8ead-43c5-abc2-b06b89dd20cd + cNF04.9a: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF04.9a). + meaning: rrid:CVCL_B9VB + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5b9e065-6855-4a11-bceb-681d8e82ae5e + ELK-TAD Luciferase Reporter HEK293 Stable: + description: '[From GFF:] ELK-TAD Luciferase Reporter HEK293 Stable' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c88fcbc9-24c1-4f2b-8d13-02f5037dcf1c + sNF96.2: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K281 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c9a87975-378b-4930-8fda-e5896c42c86c + SZ-NF2: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_YL58 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc2045df-5ebf-4491-b5b1-88d65e59b228 + Lis42_NF1_1N: + description: Human embryonic stem cell line derived from an embryo with neurofibromatosis + type 1. + meaning: rrid:CVCL_Y368 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd38ffda-2db1-47f0-af6f-8de572e06037 + Lis47_NF1_2N: + description: Human embryonic stem cell line derived from an embryo with neurofibromatosis + type 1. + meaning: rrid:CVCL_Y373 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0ca95f1-a3d9-4641-b47d-84346d9ec04a + cNF97.2a: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF97.2a). + meaning: rrid:CVCL_B9V1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d390b3f3-fea7-46d2-9bb7-dc72d59b2ccc + S462.TY: + description: MPNST tumor cell line from an NF1 patient, created by passaging + S462 cell line in mice as xenografts. + meaning: rrid:CVCL_JK02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6a101aa-9ca8-4191-9b43-eddf327ea48b + 5PNF_TDiPSsv_MM_4: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN13 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db6b3d0d-ee80-49ab-bb51-5672448e580b + cNF98.4c: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF98.4c). + meaning: rrid:CVCL_B9V5 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df513bb8-697a-4cac-ae6c-5aca6113ac24 + 6PNF_SiPSrv_PM_2: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN15 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4deb9a8-7929-44f2-974d-375771b8c681 + KCL024: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_A257 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5fdcfb8-24e7-46fa-9f48-bcbae8a90b7a + icNF97.2b: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF97.2b). + meaning: rrid:CVCL_B9V4 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb920757-ad44-4705-815e-31b5bd6105f5 + HEK293 NF1 -/- with R816X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R816X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f047cff6-98c8-4562-b589-94b864ae35a1 + NCC-MPNST4-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU16 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f17b839e-acd9-4dbc-a5bb-7d72ed0d0bd8 + hTERT NF1 ipNF03.3: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f21cb7db-ee85-48a7-8f41-e4603238bede + HEK293 NF1 -/- with WT mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with WT mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2d00598-9db3-4549-a473-16b1db349614 + GM11602: + description: Leukemia cell line derived from B-lymphocytes from an NF1 patient. + meaning: rrid:CVCL_AA02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f354ec1a-0305-4e6c-897a-10e4fba10a28 + HEK293 NF1 -/- clone 2: + description: '[From GFF:] HEK293 NF1 -/- clone 2' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f59f3308-a440-497d-8eee-8d7756a9ae2b + Schwann cell NF1 -/- with R681X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- with R681X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=faf29a50-3168-4ccd-a484-f2a78a026af3 + HEK293 NF1 -/- with R192X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. HEK293 + NF1 -/- with R192X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb67363f-d309-4c7c-ba1e-f295ba411018 + NCC-MPNST1-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc3ae45e-9a5b-4fa5-8430-f53479f07f5a + KOMP ES cell line Nf1: + description: JM8.F6 derived from C57BL/6N + meaning: rrid:MMRRC_059313-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d596eb56-33b0-4dcc-b7e4-0922a93c4134 + KOMP ES cell line Nf1: + description: JM8.F6 derived from C57BL/6N + meaning: rrid:MMRRC_059314-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e0a4cc28-022b-48ed-acf5-28ee38eb20bd + SIGTR ES cell line AA0320: + description: High throughput gene trapping was performed by inserting a gene + trap vector containing a splice-acceptor sequence upstream of a reporter + gene, β-geo (a fusion of β-galactosidase and neomycin phosphotransferase + II), into an intronic or coding region of genomic DNA. The resulting insertional + mutation creates a fusion transcript containing sequences from exons upstream + of the insertion joined to the β-geo marker, allowing cell lines where the + vector has successfully interrupted a gene to be identified. + meaning: rrid:MMRRC_025689-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8a75443-a92f-45f7-9290-0669405e2e9c GM00622: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_5M64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1edebf4d-8ea4-4071-90bf-7e934c7ab029" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1edebf4d-8ea4-4071-90bf-7e934c7ab029 GM01633: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_9Z54 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa663228-7ffe-4604-9cda-95b29b8d7386" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa663228-7ffe-4604-9cda-95b29b8d7386 GM01634: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z57 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9722c74b-e82e-4ac7-b684-4bab1a409a78" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9722c74b-e82e-4ac7-b684-4bab1a409a78 GM01639: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_5M68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2677690-2137-408e-b250-784a0cd235f4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2677690-2137-408e-b250-784a0cd235f4 GM01641: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_5M69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9db66052-f458-4400-ae1b-3f5c075dbd25" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9db66052-f458-4400-ae1b-3f5c075dbd25 GM01858: - description: "Fibroblast from Neurofibroma from an NF1 patient" + description: Fibroblast from Neurofibroma from an NF1 patient meaning: rrid:CVCL_9Z58 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4e97f99-a857-4f2d-80f1-62de8a12d037" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4e97f99-a857-4f2d-80f1-62de8a12d037 GM01859: - description: "Fibroblast from Neurofibroma from an NF1 patient" + description: Fibroblast from Neurofibroma from an NF1 patient meaning: rrid:CVCL_9Z59 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3899a07c-6fb8-4fc2-997f-c2301d6082f7" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3899a07c-6fb8-4fc2-997f-c2301d6082f7 GM01861: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z60 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46cc2e4e-d9bf-4474-b4de-448e25fb0c66" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46cc2e4e-d9bf-4474-b4de-448e25fb0c66 GM03420: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z61 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ebbfa6b-049f-4e85-af96-be49c3b5b31a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ebbfa6b-049f-4e85-af96-be49c3b5b31a GM03421: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z62 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5570368b-f20e-47ed-9656-0b9d49c53c9f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5570368b-f20e-47ed-9656-0b9d49c53c9f GM09534: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z63 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4106cadd-2071-437e-8c43-6f5751332128" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4106cadd-2071-437e-8c43-6f5751332128 GM09535: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bdf2270-d002-41bf-b75d-2a1d890f9967" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bdf2270-d002-41bf-b75d-2a1d890f9967 GM09536: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z65 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=afcff3ca-6421-4c66-bd87-94ad21493b1d" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=afcff3ca-6421-4c66-bd87-94ad21493b1d GM09539: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f77c8f5-a9a2-4d1a-a34a-79e912718c91" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f77c8f5-a9a2-4d1a-a34a-79e912718c91 GM09616: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z67 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c569a3f9-9c0c-48fe-bbb5-7ae5cb6c384a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c569a3f9-9c0c-48fe-bbb5-7ae5cb6c384a GM09617: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f34019e4-be8b-4f75-9f68-a79032c8705b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f34019e4-be8b-4f75-9f68-a79032c8705b GM09618: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_N114 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a9d486c-1cd0-4cab-b3d7-cbe17058d457" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a9d486c-1cd0-4cab-b3d7-cbe17058d457 GM09619: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bdd8125b-cf6d-45f3-8cea-20af6e21a1da" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bdd8125b-cf6d-45f3-8cea-20af6e21a1da GM09620: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=559404ce-6df0-4109-bdeb-6521d8928f1c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=559404ce-6df0-4109-bdeb-6521d8928f1c GM09621: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=026b1ceb-5f1c-4497-825c-ee3cc5d9d2ed" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=026b1ceb-5f1c-4497-825c-ee3cc5d9d2ed GM09622: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4cf20b8-9e30-4798-8281-25b83346458d" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4cf20b8-9e30-4798-8281-25b83346458d GM09625: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0843b842-e9d2-4b23-9a53-aebf01ae31e3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0843b842-e9d2-4b23-9a53-aebf01ae31e3 GM09626: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_N115 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59bac805-44b6-4397-8195-6005fcedcd95" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59bac805-44b6-4397-8195-6005fcedcd95 GM09627: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96456d2b-062d-42ab-a1ce-ff3df6f7ab5b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96456d2b-062d-42ab-a1ce-ff3df6f7ab5b GM09628: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z75 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b636771-68eb-4a86-801e-546bcb4f9b25" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b636771-68eb-4a86-801e-546bcb4f9b25 GM09629: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z76 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86145b27-da2e-4b32-9ddc-e247374fe10e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86145b27-da2e-4b32-9ddc-e247374fe10e GM09630: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be65ffe-18cb-46c4-b910-6e5a3cc5612a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be65ffe-18cb-46c4-b910-6e5a3cc5612a GM09631: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z78 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22ca8958-b953-461d-9301-016f57cd08a5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22ca8958-b953-461d-9301-016f57cd08a5 GM09632: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z79 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a28aea84-6495-4863-80cc-08066079deef" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a28aea84-6495-4863-80cc-08066079deef GM09633: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cba1c774-499d-4d01-b3d2-a62f670b03ce" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cba1c774-499d-4d01-b3d2-a62f670b03ce GM09634: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z81 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=327fcda4-f2ef-4cb5-9245-d3256960f17f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=327fcda4-f2ef-4cb5-9245-d3256960f17f GM09635: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9d1561b3-b430-4a9b-984d-1c77a02f1a23" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9d1561b3-b430-4a9b-984d-1c77a02f1a23 GM09636: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b213001-31a3-4c59-bf32-4e5407c01e82" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b213001-31a3-4c59-bf32-4e5407c01e82 GM09637: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z84 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fd4f461-6137-4922-81b1-e9f30d993df1" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fd4f461-6137-4922-81b1-e9f30d993df1 GM09638: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z85 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f00ae7c4-4eea-49e4-92d1-43382dfd31bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f00ae7c4-4eea-49e4-92d1-43382dfd31bb GM09639: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z86 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd411ce0-865d-47d7-a5c4-84084f5aadb5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd411ce0-865d-47d7-a5c4-84084f5aadb5 GM09640: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z87 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6a894263-7e2b-46f5-81b1-9aa351590843" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6a894263-7e2b-46f5-81b1-9aa351590843 GM09641: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z88 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc42f6e8-494c-49ff-880f-be2352f3a87e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc42f6e8-494c-49ff-880f-be2352f3a87e GM09642: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z89 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6d3fc47-cd5d-4b7e-a5b7-7c10cecb2490" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6d3fc47-cd5d-4b7e-a5b7-7c10cecb2490 GM09649: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z90 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4996ae57-c5df-4832-8990-cea9133004bc" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4996ae57-c5df-4832-8990-cea9133004bc GM09650: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z91 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b16247aa-fd06-4103-9f5e-50e0e7d06805" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b16247aa-fd06-4103-9f5e-50e0e7d06805 GM09651: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z92 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=432fefde-722b-44f0-8f11-bbc97920b5f6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=432fefde-722b-44f0-8f11-bbc97920b5f6 GM09652: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z93 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08309e7c-d0a5-457e-91bc-9c5113347ee2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08309e7c-d0a5-457e-91bc-9c5113347ee2 GM09688: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z94 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09799642-3547-4033-a094-5ba1dd08da60" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09799642-3547-4033-a094-5ba1dd08da60 GM09689: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z95 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=220c8dae-1759-4834-b952-c9b68469137a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=220c8dae-1759-4834-b952-c9b68469137a GM09690: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z96 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41307a11-4252-4563-bb7d-afe570cf1620" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41307a11-4252-4563-bb7d-afe570cf1620 GM09691: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9Z97 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7df4a356-0194-47d4-9a78-291b8083ed18" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7df4a356-0194-47d4-9a78-291b8083ed18 GM09692: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z98 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c83b346e-57de-41b3-9a28-7e60a2f78483" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c83b346e-57de-41b3-9a28-7e60a2f78483 GM09693: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_9Z99 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1dbbb94-a4e6-4829-a3db-455480b0a535" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1dbbb94-a4e6-4829-a3db-455480b0a535 GM09694: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_6F53 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6b2e6bfa-e869-4970-a71c-10abd3224ea9" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6b2e6bfa-e869-4970-a71c-10abd3224ea9 GM09886: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9T23 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f597b96-5566-45f6-81c6-592c82cb3465" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f597b96-5566-45f6-81c6-592c82cb3465 GM09887: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_9X49 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed96e95-c815-4151-ade9-40510601255f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed96e95-c815-4151-ade9-40510601255f GM09944: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_AA00 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0abcee2-581c-4c1a-9ef8-93b57dd0f96d" - GM10501: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R95 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb" - GM10502: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R96 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965" - GM10657: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R97 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7" - GM10659: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1R98 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3" - GM11601: - description: "Leukemia cell line derived from B-lymphocytes from an NF1 patient." - meaning: rrid:CVCL_AA01 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2f62c57-a1b8-4867-9c91-04406f261cfa" - GM11602: - description: "Leukemia cell line derived from B-lymphocytes from an NF1 patient." - meaning: rrid:CVCL_AA02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f354ec1a-0305-4e6c-897a-10e4fba10a28" - GM12517: - description: "Human/rodent somatic cell hybrid" - meaning: rrid:CVCL_1S66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0abcee2-581c-4c1a-9ef8-93b57dd0f96d GM21674: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_HL11 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2e3f513-8780-4f7e-985a-4dd4eab7de95" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2e3f513-8780-4f7e-985a-4dd4eab7de95 GM21675: - description: "Fibroblast derived from skin from an NF1 patient" + description: Fibroblast derived from skin from an NF1 patient meaning: rrid:CVCL_HL12 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf150ecf-4971-4500-ae94-5d25e4895d63" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf150ecf-4971-4500-ae94-5d25e4895d63 GM21843: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_BA07 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4280272c-022d-45bd-9c0f-20d96b69aba8" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4280272c-022d-45bd-9c0f-20d96b69aba8 GM21844: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_BA08 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7c5369fa-2ea8-45a1-93be-d6e22e1ac695" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7c5369fa-2ea8-45a1-93be-d6e22e1ac695 GM21845: - description: "Lymphoblastoid cell line derived from B-lymphocytes" + description: Lymphoblastoid cell line derived from B-lymphocytes meaning: rrid:CVCL_BA09 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3281d1ba-5d0d-4dca-b583-9c610814fb76" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3281d1ba-5d0d-4dca-b583-9c610814fb76 GM21865: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_BA10 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=38dcffa4-463a-482b-8d6c-5d787ac3a1c4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=38dcffa4-463a-482b-8d6c-5d787ac3a1c4 GM22279: - description: "Fibroblast from an NF1 patient" + description: Fibroblast from an NF1 patient meaning: rrid:CVCL_BA11 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ba4aabde-a800-4cca-b4de-1f4f4c8c06cc" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ba4aabde-a800-4cca-b4de-1f4f4c8c06cc GM22606: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_BU80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=809601e0-75ef-460c-9e95-9c454e06c474" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=809601e0-75ef-460c-9e95-9c454e06c474 GM22607: - description: "Fibroblast derived from skin from an NF1 patient" + description: Fibroblast derived from skin from an NF1 patient meaning: rrid:CVCL_BU81 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc4c4f3b-34c3-447f-9422-0262d7b43ae5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc4c4f3b-34c3-447f-9422-0262d7b43ae5 GM22608: - description: "Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient" + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient meaning: rrid:CVCL_BU82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce964197-a694-41fb-8f25-66cd84c86e50" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce964197-a694-41fb-8f25-66cd84c86e50 GM22609: - description: "Fibroblast derived from skin from an NF1 patient" + description: Fibroblast derived from skin from an NF1 patient meaning: rrid:CVCL_BU83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f18f5f6b-09c7-4367-89d5-c065137888db" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f18f5f6b-09c7-4367-89d5-c065137888db GM23312: - description: "Tumor-derived cell line from chest an NF1 patient" + description: Tumor-derived cell line from chest an NF1 patient meaning: rrid:CVCL_CW86 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b104c61a-5a55-4811-97fc-7ce0683b2a14" - GM23338: - description: "[From GFF:] iPSC NF1 WT, PGP1 cells" - meaning: rrid:CVCL_F182 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c4e4b03-5975-4708-a25c-f6c45cbe3abf" - GP2d: - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap)." - meaning: rrid:CVCL_2450 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c62fab0b-8aa2-4732-9ffb-7d80b8b425ab" - GWH04: - description: "Mutation of NF1, p.Ter640Argext (c.1918T>C), Unspecified zygosity (PubMed=36169178)." - meaning: rrid:CVCL_C0W3 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=298cca5d-cc3d-4215-968e-8ac5f890ae22" - "HAP1 NF1 (-) 1": - meaning: rrid:CVCL_TA51 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=300695f7-5d65-413f-8f6c-290c4b09f710" - "HAP1 NF1 (-) 2": - meaning: rrid:CVCL_TA52 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72511c95-eaa4-403d-914e-2658e2cabd51" - "HAP1 NF1 (-) 3": - meaning: rrid:CVCL_TA53 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f58179b-18b4-48ee-b3b0-fe8536815838" - "HAP1 NF1 (-) 4": - meaning: rrid:CVCL_TA54 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6d95003f-3800-4d3a-b2fb-a5fbf7adae3c" - "HBE135-E6E7": - description: "[From ATCC:] The HBE135-E6E7 cell line was derived from normal bronchial epithelium taken from a man undergoing lobectomy for squamous cell carcinoma. Cells from the primary explant in their first passage were infected with the recombinant retrovirus LXSN16E6E7 containing the human papilloma virus (HPV) E6E7 gene." - meaning: rrid:CVCL_3695 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a1a3741-0337-4067-95ab-fb0dc9562d66" - "HCT 116": - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0291 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=077ce9fd-c141-4baa-b8ac-80aa2922a041" - "HCT 15": - description: "1 alleles of G13D mutation in KRAS gene" - meaning: rrid:CVCL_0292 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dc12b0e-f9e9-4486-a923-720a8a36bb4e" - HEK293: - description: "[From ATCC:] This is a hypotriploid human cell line." - meaning: rrid:CVCL_0045 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7b6dcc42-3c32-4008-8b2c-309aa01b17be" - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice": - description: "[From GFF:] HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae765b00-9189-4a72-8ae7-cddc41e24055" - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice": - description: "[From GFF:] HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b4b8eca-f981-440d-b478-0a5483353368" - "HEK293 NF1 -/- Exon 47 insT #14": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 47 insT #14" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=130fd347-28e1-46c2-a72d-d243e99322b7" - "HEK293 NF1 -/- Exon 52 R2550X #5": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 52 R2550X #5" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d565aea-0917-428b-9101-d2a19f3fbcf1" - "HEK293 NF1 -/- clone 2": - description: "[From GFF:] HEK293 NF1 -/- clone 2" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f59f3308-a440-497d-8eee-8d7756a9ae2b" - "HEK293 NF1 -/- with R1306X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1306X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02dacc42-ea46-48fb-a4df-7a875d801086" - "HEK293 NF1 -/- with R192X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R192X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb67363f-d309-4c7c-ba1e-f295ba411018" - "HEK293 NF1 -/- with R1947X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1947X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14353c91-2be9-4617-b337-c29080961826" - "HEK293 NF1 -/- with R2550X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R2550X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aa32fc67-9cc3-4d31-bcbd-f7044f9fd484" - "HEK293 NF1 -/- with R461X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R461X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f29aa26-1d05-453a-a6ac-d4e37d609dba" - "HEK293 NF1 -/- with R681X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R681X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=32f73d96-fd2a-4966-a150-ba5fa47d150c" - "HEK293 NF1 -/- with R816X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R816X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f047cff6-98c8-4562-b589-94b864ae35a1" - "HEK293 NF1 -/- with WT mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2d00598-9db3-4549-a473-16b1db349614" - "HEK293 NF1 -/- with WT tagged mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT tagged mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96d339f9-9d19-40c3-8f81-3590f7c00205" - "HPAF-II": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11787853, PubMed=12068308, PubMed=15367885, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0313 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd37b60c-e8f7-451a-87e2-20792451c6fe" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b104c61a-5a55-4811-97fc-7ce0683b2a14 + DD2345: + description: An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line + meaning: rrid:CVCL_9J79 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2e792f78-55b0-4091-9f86-6b78abd920bb HPS1312: meaning: rrid:CVCL_UN64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e85ecf49-5767-41bd-86f8-2c24c3565a14" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e85ecf49-5767-41bd-86f8-2c24c3565a14 HPS1313: meaning: rrid:CVCL_A3UD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f0bb3a66-ad46-4458-bb2a-eb01d5860aaf" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f0bb3a66-ad46-4458-bb2a-eb01d5860aaf HPS1314: meaning: rrid:CVCL_A3UE - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2b29409-3d0c-4ff6-a1d4-eb1ea8e856bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2b29409-3d0c-4ff6-a1d4-eb1ea8e856bb HPS1315: meaning: rrid:CVCL_A3UF - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2c7033c-1cc1-437c-8dd5-699ce1c52c31" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2c7033c-1cc1-437c-8dd5-699ce1c52c31 HPS1316: meaning: rrid:CVCL_A3UG - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=88c655aa-2117-4a84-a15f-ddfa3abcf0e9" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=88c655aa-2117-4a84-a15f-ddfa3abcf0e9 HPS1317: meaning: rrid:CVCL_A3UH - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d1529d1-682a-493f-accf-c498a8a06f29" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d1529d1-682a-493f-accf-c498a8a06f29 HPS2250: meaning: rrid:CVCL_UP04 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85718709-ca03-493c-be51-f63650440435" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85718709-ca03-493c-be51-f63650440435 HPS2251: meaning: rrid:CVCL_A3RL - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d29aaa05-2dae-4f67-b8b1-742d182a6b83" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d29aaa05-2dae-4f67-b8b1-742d182a6b83 HPS2252: meaning: rrid:CVCL_A3RM - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d4806ba-76ec-452c-881b-7a7b48828790" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d4806ba-76ec-452c-881b-7a7b48828790 HPS2253: meaning: rrid:CVCL_A3RN - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b5a2e06e-fd9e-4586-9ab9-4a950815d4c1" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b5a2e06e-fd9e-4586-9ab9-4a950815d4c1 HPS2254: meaning: rrid:CVCL_A3RP - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a687df-afc8-493f-8f5a-a40eceb32946" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a687df-afc8-493f-8f5a-a40eceb32946 HPS2255: meaning: rrid:CVCL_A3RQ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25a6d925-3be3-42d1-8373-e7f8c5fe85aa" - "HS-PSS": - description: "A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be." - meaning: rrid:CVCL_8717 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd49d4e2-575e-4e89-8317-cff02db4882c" - "HS-Sch-2": - description: "A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be." - meaning: rrid:CVCL_8718 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19bba596-fc3d-479b-9675-afa369b44dee" - HS53T: - description: "human NF1-associated MPNST derived cell line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86dcdce8-8416-4157-a31e-04c6edd3ca65" - HSC1λ: - description: "human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0193c87-8813-4841-92e7-ee5095bd94fe" - HTh74: - description: "Established from a tumor implanted into a nude mice. Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (PubMed=30737244)." - meaning: rrid:CVCL_6288 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ace6c78c-3ea6-426d-83b3-1ceeecd74db3" - "HTh74 clone 7": - description: "Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (from parent cell line)." - meaning: rrid:CVCL_AT82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d86c2e88-3de9-4c0f-9cb5-de2921b8207f" - "HeLa SilenciX NF1": - description: "HeLa cervical cancer cells with stable (EBV-based siRNA) knockdown of the NF1 gene." - meaning: rrid:CVCL_KT82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2549e536-b033-43e4-acf6-501499b6e498" - "HuP-T4": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1300 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1e7bf984-5c1f-463e-89e1-b5d9b552aef5" - "JH-2-002": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1bc84ef2-208f-4f0e-8045-6be47fd968de" - "JH-2-009": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0bc812b4-f2af-40c4-8245-1070ab12f627" - "JH-2-031": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4241b7ff-c08e-4c6d-b2c1-9de9ac91f72b" - KCL024: - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_A257 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5fdcfb8-24e7-46fa-9f48-bcbae8a90b7a" - KCL025: - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_A258 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=18ba4c2e-e8d5-4032-a6ab-d0fca3f0f984" - "KOMP ES cell line Nf1": - description: "JM8.F6 derived from C57BL/6N" - meaning: "rrid:MMRRC_059313-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d596eb56-33b0-4dcc-b7e4-0922a93c4134" - "KOMP ES cell line Nf1": - description: "JM8.F6 derived from C57BL/6N" - meaning: "rrid:MMRRC_059314-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e0a4cc28-022b-48ed-acf5-28ee38eb20bd" - "KP-3": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=21607521, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_3005 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a550816-e561-4d4b-a25c-995ea23b8a41" - "LCLC-97TM1": - description: "2 alleles of G12V mutation in KRAS gene" - meaning: rrid:CVCL_1376 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7fe3fbf-d242-40b6-9d33-c19e8e0057e0" - LS180: - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=20570890, PubMed=24755471, ATCC)." - meaning: rrid:CVCL_0397 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54b8989a-e04f-47ac-bc0c-a5871b943228" - LS513: - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471)." - meaning: rrid:CVCL_1386 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f95c38-f30f-4ce8-8a92-97baecbc53fc" - Lis42_NF1_1N: - description: "Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1." - meaning: rrid:CVCL_Y368 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd38ffda-2db1-47f0-af6f-8de572e06037" - Lis47_NF1_2N: - description: "Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1." - meaning: rrid:CVCL_Y373 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0ca95f1-a3d9-4641-b47d-84346d9ec04a" - LoVo: - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0399 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5ce9c8-7f59-43b0-ac57-3a883d75dff3" - "Lu-65": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1392 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6365e6d0-eefd-4778-9e0f-d8c549838ff2" - "Lu-99": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap)." - meaning: rrid:CVCL_3015 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31448c47-8e6d-412c-917a-9f92c53ad687" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25a6d925-3be3-42d1-8373-e7f8c5fe85aa + MCRIi020-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d941428a-ebcb-4acf-90ae-107d7cfc52d1 + MCRIi021-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1ME + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a676545-f9b5-4fdb-bf0f-3b68dfdb58b8 + MCRIi022-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MF + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb564630-535a-4d14-8a07-f2b4e64f4926 + MCRIi023-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MG + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8295296a-e1d7-4c9f-beaa-2ac02d09c149 + QQ0588: + description: An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line + meaning: rrid:CVCL_8Y66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53c871d3-6f75-49a6-aa73-42d0ead2298b + RG-137: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B564 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b9d9f06-2918-490e-a783-1655c757d922 + RG-138: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B565 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6e0a7ed-94f6-42e1-9700-6cafcb00f426 + RG-139: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B566 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1dc0e42-68f8-4650-89ac-37a6acdeb10e + RG-140: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B567 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2fe9632c-b6db-443f-a512-4b2523a470e0 + RG-141: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B568 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aba67450-594d-422b-a7fe-6c69a882b859 + RG-235: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA.' + meaning: rrid:CVCL_B653 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=978d317f-f1d6-4039-a2f5-f0787adf589a + RG-315: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, + c.5839C>T); Heterozygous (ISCR).' + meaning: rrid:CVCL_B721 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0360411b-59dd-457a-ab6f-38a9182c425e + STR-I-437-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y599 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01040031-60ba-4da5-96b0-d4a0a2f9131b + STR-I-441-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y600 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1372bf73-291f-48f9-9207-81120a299675 + STR-I-443-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y601 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5352596f-7192-473c-85b3-2aeb0fbf8e48 + SZ-NF6: + description: 'From: Shaare Zedek Medical Center, The Hebrew University, Jerusalem, + Israel., Mutation of NF1, c.4269+1G>C, Unspecified zygosity (Direct author + submission)' + meaning: rrid:CVCL_YY00 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7ae798-a355-4b78-b1c3-6c82e3f917a7 + '1507.2': + meaning: rrid:CVCL_1Y71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4304050f-f24a-45b9-9025-8e3e88d0b377 + 10/9CRC1: + meaning: rrid:CVCL_8478 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25c617df-ff54-4ba5-b293-d9fcc9be39ce + 10CM: + description: Mutation of NF1, p.Arg440Ter (c.1318C>T), Unspecified zygosity + (PubMed=26744134). Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified + zygosity (PubMed=26744134). + meaning: rrid:CVCL_VJ83 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423cc0f3-8a43-4e10-a9a4-d529aa78f022 + 2XSB: + meaning: rrid:CVCL_A7NI + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f4e4596-0c7d-4d41-b9ff-73ecebd30263 + 4/30PRR: + meaning: rrid:CVCL_8480 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0aed5bf6-d5e2-4a6d-ac3b-a51b5e8bbb8b + 862L: + meaning: rrid:CVCL_8477 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6faf7e00-d770-4527-9384-539f6db31977 + 9/3L: + meaning: rrid:CVCL_8479 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c98ce5c-5cf1-4829-943d-5142073583d8 + Abcam A-549 NF1 KO: + description: Mutation of KRAS, p.Gly12Ser (c.34G>A), Homozygous (from parent + cell line). + meaning: rrid:CVCL_B9NJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d605ae2e-969a-4956-bac5-5e36654d7b41 + Abcam HCT 116 NF1 KO: + description: Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (from parent + cell line). + meaning: rrid:CVCL_B8LD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5ec9375-0564-414a-94ad-86d5083b440f + Abcam HeLa NF1 KO: + description: Nf1 knockout cell + meaning: rrid:CVCL_B1YJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b26e0c8b-689f-4018-bf27-e2d3a522e039 + Abcam MCF-7 NF1 KO: + description: Nf1 knockout cell + meaning: rrid:CVCL_B8ZE + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24719e11-8ac2-452c-9424-20d75fc26d82 + Abcam U-87MG SNCA KO: + description: Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), + Heterozygous (from parent cell line). + meaning: rrid:CVCL_C0BJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5f5d4a-95f7-4e5c-9db1-d13fbc9748a7 + AMC-106: + meaning: rrid:CVCL_9477 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf77b1e3-93be-4b4e-bc34-85d8b9d06a81 + BayGenomics ES cell line XF344: + description: Nf1 knockout cell + meaning: rrid:CVCL_PR85 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=60633d59-0230-47c3-9d40-08b0ae194b6d + CML-6M: + description: Pigmented. Mutation of NF1, p.Pro1599fs (c.4795delCinsTT), Heterozygous + (PubMed=31175136). + meaning: rrid:CVCL_0D24 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=acd954de-1f36-41ad-8ce0-ac738aa840ba + CPTC-NF1-1: + meaning: rrid:CVCL_C2NU + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65d07476-2469-4679-85b2-e2ca67f3b01b + CPTC-NF1-2: + meaning: rrid:CVCL_C2NV + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f410431d-7571-4302-8870-eb115b71d0ce + CPTC-NF1-3: + meaning: rrid:CVCL_C2NW + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42257ac4-1950-4541-9bee-b9a965e2fa86 + CTV-1: + description: Mutation of NF1, p.Gly1532Arg (c.4594G>A), Heterozygous (PubMed=22675565, + Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1150 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37cbf7b9-f74c-4407-8541-86c17e394c5d + D-566MG: + description: Mutation of NF1, p.Ile941Serfs*13 (c.2820delC), Heterozygous + (Cosmic-CLP). + meaning: rrid:CVCL_1166 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc7c0fee-8a89-49a2-b58c-eff50448006d + FMS-1: + meaning: rrid:CVCL_IS33 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b14a6ae1-829c-4ae3-9149-9fcf6cc6c57d + FTC-133: + description: Has a near-homozygous genome (NHG). Mutation of NF1, p.Cys167Ter + (c.501T>A), Homozygous (PubMed=30737244). + meaning: rrid:CVCL_1219 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a630172-cf98-41c1-ae06-c436900fb513 + FU-SFT8710: + meaning: rrid:CVCL_ZE77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b96c1fa0-5284-424a-b29e-338db3c8b292 + GI-ME-N: + description: Gene deletion, NF1, Heterozygous (PubMed=20655465). Mutation + of NF1, Microdeletion, Heterozygous (PubMed=20655465). + meaning: rrid:CVCL_1232 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe5b49ff-6d77-4de3-adc3-0fc97fd076e4 + GI-ME-NrCDDP500: + description: Gene deletion, NF1, Heterozygous (from parent cell line). Mutation + of NF1, Microdeletion, Heterozygous (from parent cell line). + meaning: rrid:CVCL_RS22 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=73b8caeb-cc91-4d81-b076-25d611949807 + GI-ME-NrDOX5: + description: Gene deletion, NF1, Heterozygous (from parent cell line). Mutation + of NF1, Microdeletion, Heterozygous (from parent cell line). + meaning: rrid:CVCL_RS07 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a03250ca-0914-4318-b5c6-5b5a86ca1965 + GI-ME-NrVCR14: + description: Gene deletion, NF1, Heterozygous (from parent cell line). Mutation + of NF1, Microdeletion, Heterozygous (from parent cell line). + meaning: rrid:CVCL_RR32 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25fa8030-970e-48ec-8e22-55e23a747164 + GM10501: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R95 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb + GM10502: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R96 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965 + GM10657: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R97 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7 + GM10659: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R98 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3 + GM12517: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1S66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81 + GWH04: + description: Mutation of NF1, p.Ter640Argext (c.1918T>C), Unspecified zygosity + (PubMed=36169178). + meaning: rrid:CVCL_C0W3 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=298cca5d-cc3d-4215-968e-8ac5f890ae22 + HAP1 NF1 (-) 1: + meaning: rrid:CVCL_TA51 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=300695f7-5d65-413f-8f6c-290c4b09f710 + HAP1 NF1 (-) 2: + meaning: rrid:CVCL_TA52 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72511c95-eaa4-403d-914e-2658e2cabd51 + HAP1 NF1 (-) 3: + meaning: rrid:CVCL_TA53 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f58179b-18b4-48ee-b3b0-fe8536815838 + HAP1 NF1 (-) 4: + meaning: rrid:CVCL_TA54 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6d95003f-3800-4d3a-b2fb-a5fbf7adae3c + HTh74: + description: Established from a tumor implanted into a nude mice. Mutation + of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (PubMed=30737244). + meaning: rrid:CVCL_6288 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ace6c78c-3ea6-426d-83b3-1ceeecd74db3 + HTh74 clone 7: + description: Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous + (from parent cell line). + meaning: rrid:CVCL_AT82 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d86c2e88-3de9-4c0f-9cb5-de2921b8207f MCF10A_NF1_1: meaning: rrid:CVCL_C1A6 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd6b1f88-b716-47d4-9869-84d58b18c2eb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd6b1f88-b716-47d4-9869-84d58b18c2eb MCF10A_NF1_7A1: meaning: rrid:CVCL_C1A7 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f506b298-5b5e-4ea6-abe3-49b4f69d871b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f506b298-5b5e-4ea6-abe3-49b4f69d871b MCF10A_NF1_7B2: meaning: rrid:CVCL_C1A8 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7e0c9b3-008d-415f-bd1e-8fc33d55e497" - "MCRIi020-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1MD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d941428a-ebcb-4acf-90ae-107d7cfc52d1" - "MCRIi021-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1ME - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a676545-f9b5-4fdb-bf0f-3b68dfdb58b8" - "MCRIi022-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1MF - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb564630-535a-4d14-8a07-f2b4e64f4926" - "MCRIi023-A": - description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne, Australia." - meaning: rrid:CVCL_A1MG - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8295296a-e1d7-4c9f-beaa-2ac02d09c149" - "MH/Nike": - description: "Mutation of NF1, p.Ala2176fs (c.6525delG), Homozygous (PubMed=31175136)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7e0c9b3-008d-415f-bd1e-8fc33d55e497 + Mes-9: + meaning: rrid:CVCL_H658 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b61a902-c96f-4849-abd3-7631963e1cc5 + MH/Nike: + description: Mutation of NF1, p.Ala2176fs (c.6525delG), Homozygous (PubMed=31175136). meaning: rrid:CVCL_DN29 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cb659ee-8d25-4016-a2a5-4c230bfc933e" - "MIA PaCa-2": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=7961102, PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=12068308, PubMed=21607521, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0428 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee325d43-d215-4610-aa67-011ea95efaab" - "MPNST 724": - description: "human MPNST cell line" - meaning: rrid:CVCL_AU20 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7db6b49f-7eec-4b47-bbdc-675a8a464735" - "MPNST-14": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cb659ee-8d25-4016-a2a5-4c230bfc933e + MPNST-14: meaning: rrid:CVCL_AU21 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=81ae2a05-5102-473f-88fa-9d9bbe8fd35e" - "MPNST-642": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=81ae2a05-5102-473f-88fa-9d9bbe8fd35e + MPNST-642: meaning: rrid:CVCL_AU19 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=818f4c93-dbd3-41f7-b557-f264f7949c6e" - "MPNST-90": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=818f4c93-dbd3-41f7-b557-f264f7949c6e + MPNST-90: meaning: rrid:CVCL_J355 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd3db98f-0ec9-40df-bc06-5e314c0fc671" - "MPNST-91": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd3db98f-0ec9-40df-bc06-5e314c0fc671 + MPNST-91: meaning: rrid:CVCL_J356 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fd09582-99a8-40d5-a16b-b250a6975e44" - "MPNST-92": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fd09582-99a8-40d5-a16b-b250a6975e44 + MPNST-92: meaning: rrid:CVCL_J357 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa12d6e9-6547-43ad-a666-c17c7c1a9cb3" - "MUG-Mel1": - description: "Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa12d6e9-6547-43ad-a666-c17c7c1a9cb3 + MUG-Mel1: + description: Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407). meaning: rrid:CVCL_VV72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce4f191-b7ce-437d-8cef-f6de332040e0" - "MUG-Mel1 clone C8": - description: "Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce4f191-b7ce-437d-8cef-f6de332040e0 + MUG-Mel1 clone C8: + description: Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407). meaning: rrid:CVCL_VV73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=590ebb66-5944-4cf7-accc-23e18d6c3818" - "MUG-Mel1 clone D5": - description: "Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=590ebb66-5944-4cf7-accc-23e18d6c3818 + MUG-Mel1 clone D5: + description: Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407). meaning: rrid:CVCL_VV74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96f2ab08-2c90-4ef9-9d56-1705ee49cecc" - "Mes-9": - meaning: rrid:CVCL_H658 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b61a902-c96f-4849-abd3-7631963e1cc5" - N10: - description: "N5 and N10 cells lines underwent CRISPR/Cas9 targeting against NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de94c5d9-6feb-402f-a0c6-6ac3389907c6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96f2ab08-2c90-4ef9-9d56-1705ee49cecc N206: meaning: rrid:CVCL_C885 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6cbf7434-7dd5-4ed5-9ca6-77e65e2b4b36" - "NB90-4": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6cbf7434-7dd5-4ed5-9ca6-77e65e2b4b36 + NB90-4: meaning: rrid:CVCL_A5PQ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9bacf245-10fb-48b1-ae87-1034bd1259a0" - "NB90-6": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9bacf245-10fb-48b1-ae87-1034bd1259a0 + NB90-6: meaning: rrid:CVCL_A5PR - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fdfba143-b6fe-494f-ae25-8796009e8090" - "NCC-MPNST1-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU12 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc3ae45e-9a5b-4fa5-8430-f53479f07f5a" - "NCC-MPNST2-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU13 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f646e44-5263-4f80-bb94-b297a875c52a" - "NCC-MPNST3-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU14 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7fe31236-bc93-449b-b559-9394999be926" - "NCC-MPNST3-X2-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU15 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b604846-d41c-4969-a79a-9660c04e585c" - "NCC-MPNST4-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU16 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f17b839e-acd9-4dbc-a5bb-7d72ed0d0bd8" - "NCC-MPNST5-C1": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_YU17 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=827f08a1-3d0f-4fd8-98e4-fb5c40a9c742" - "NCI-H1373": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, DepMap)." - meaning: rrid:CVCL_1465 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a14754e6-1c26-4224-9ef9-a1abfd1538eb" - "NCI-H1385": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap)." - meaning: rrid:CVCL_1466 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=93469888-1234-4f52-b3a7-175423b817cc" - "NCI-H1651": - description: "Mutation of NF1, p.Arg997fs*15 (c.2990delG), Heterozygous (Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fdfba143-b6fe-494f-ae25-8796009e8090 + NCI-H1651: + description: Mutation of NF1, p.Arg997fs*15 (c.2990delG), Heterozygous (Cosmic-CLP, + DepMap). meaning: rrid:CVCL_1484 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c82d4706-1c04-46d2-9d23-6b5a7fc24767" - "NCI-H1792": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1495 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d28192f0-d180-40e1-b184-de3fed398e72" - "NCI-H1838": - description: "Mutation of NF1, p.Asn184fs*17 (c.548_549insA), Heterozygous (Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c82d4706-1c04-46d2-9d23-6b5a7fc24767 + NCI-H1838: + description: Mutation of NF1, p.Asn184fs*17 (c.548_549insA), Heterozygous + (Cosmic-CLP, DepMap). meaning: rrid:CVCL_1499 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7008ce3-09ef-4150-a793-69bdde435b66" - "NCI-H1944": - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1508 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e3ae7e3f-d6ae-48d9-8e08-e2625c048642" - "NCI-H2030": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1517 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177c35b5-d859-4bf2-870b-9311ef059159" - "NCI-H2122": - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1531 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=12d08160-d127-463a-9e6e-c62347f9e756" - "NCI-H23": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=17088437)." - meaning: rrid:CVCL_1547 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95e9ea19-3d84-43a5-b003-347ecec6b1fa" - "NCI-H2444": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1552 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=da179d37-bc2d-4725-8621-f8ec49b917d0" - "NCI-H358": - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=9649128, PubMed=12068308)." - meaning: rrid:CVCL_1559 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cca5b217-ce0b-4c2b-814f-54fefb967475" - "NCI-H441": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1561 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=665f978b-9fec-4f0b-8921-058a94b84bcd" - "NCI-H647": - description: "2 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1574 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df53b267-e448-4051-a0d8-1db4da3c5c41" - "NCI-H727": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1584 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d124e590-59ba-44c6-9c9f-0b0a3c96862c" - "NCI-H747": - description: "1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1587 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06004dd0-1122-46cc-b049-8349d9511c64" - NF1: - description: "Cell line from an NF1 patient; unclear if derived from tumor or non-tumor tissue." - meaning: rrid:CVCL_JG80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a8a362e-e3be-4bc3-be7e-d0a0865b9c31" - "NF1+/- hiPSC-SCPs": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa3052b-d40a-4f73-b12e-b68c472497bb" - "NF1-/- hiPSC-SCPs": - description: "Collected during surgical resection from patients with NF1-MPNST" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc7520bc-3deb-43c2-81e9-b71cbf4daa65" - "NF1-R68X Embryonic cells": - description: "[From GFF:] NF1-R68X Embryonic cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90748442-be62-44f1-899e-804cd5600823" - NF10.1: - description: "NF1-deficient MPNST tumor cell line from an NF1 patient." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2e468b4-b8cf-4473-b5f5-b7f47415d40f" - NF11.1: - description: "NF1-deficient MPNST tumor cell line from an NF1 patient." - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc674458-affb-46a3-8a48-90fe556b44d1" - "NF1C-FiPS-SV4F7": - description: "NF1(-/-) iPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=00f8dcc6-a2b2-4fc2-a327-e87367bffa21" - NF1‐iN: - description: "fibroblasts cell lines from a NF1 patient" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e608c5ee-fd65-4a08-9c89-9bf16f83956f" - "NFS-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7008ce3-09ef-4150-a793-69bdde435b66 + NFS-1: meaning: rrid:CVCL_1Y69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e6866e8-c67d-4650-a0a3-a10a5a8bdb49" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e6866e8-c67d-4650-a0a3-a10a5a8bdb49 NGP: meaning: rrid:CVCL_2141 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd026e3f-c345-4e67-8d79-31c1cd295a25" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd026e3f-c345-4e67-8d79-31c1cd295a25 NMB: meaning: rrid:CVCL_2143 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49286dfd-632c-4f62-834f-d1441e05fde5" - "NMS-2": - description: "human MPNST cell lines" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49286dfd-632c-4f62-834f-d1441e05fde5 + NMS-2: + description: human MPNST cell lines meaning: rrid:CVCL_4662 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=83512f26-8cc3-48db-8f66-1b490a943eb1" - "NMS-2PC": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=83512f26-8cc3-48db-8f66-1b490a943eb1 + NMS-2PC: meaning: rrid:CVCL_L810 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50b33e18-9c4a-470c-b982-7f612be9a79b" - "NMS-PC": - description: "human MPNST cell lines" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c7fb76f-0aae-4e0c-9a69-f50f6a5c5ebb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50b33e18-9c4a-470c-b982-7f612be9a79b NZM022: - description: "Mutation of NF1, p.Arg1362Ter (c.4084C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Arg1362Ter (c.4084C>T), Unspecified zygosity + (PubMed=32567790). meaning: rrid:CVCL_D825 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14569691-bdb1-4cd7-ae1c-943f100e93ff" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14569691-bdb1-4cd7-ae1c-943f100e93ff NZM041: - description: "Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). + Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_S426 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d017560-faf4-4230-a9cb-b9e742b158c4" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d017560-faf4-4230-a9cb-b9e742b158c4 NZM047: - description: "Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). + Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_S424 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=416e4ab2-7916-4853-9cf8-4ff76aec072a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=416e4ab2-7916-4853-9cf8-4ff76aec072a NZM072: - description: "Mutation of NF1, p.Arg416Ter (c.1246C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Arg416Ter (c.1246C>T), Unspecified zygosity + (PubMed=32567790). meaning: rrid:CVCL_0D36 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb8aed26-e95a-4b7d-b4fb-d4b9f1847c9c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb8aed26-e95a-4b7d-b4fb-d4b9f1847c9c NZM077: - description: "Mutation of NF1, p.Pro1323Ser (c.3967C>T), Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.Pro1323Ser (c.3967C>T), Unspecified zygosity + (PubMed=32567790). meaning: rrid:CVCL_0D40 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0b08c4c-2662-47b2-9eb0-306a8871f92e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0b08c4c-2662-47b2-9eb0-306a8871f92e NZM087: - description: "Mutation of NF1, p.His1170Tyr, Unspecified zygosity (PubMed=32567790)." + description: Mutation of NF1, p.His1170Tyr, Unspecified zygosity (PubMed=32567790). meaning: rrid:CVCL_0D47 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84d5c1ae-b82b-4b80-ab7a-3884c8efafda" - "Nf1-/- Epithelial lung cells": - description: "[From GFF:] Nf1-/- Epithelial lung cells, derived from HBE135-E6E7 epithelial lung cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=779714c8-f522-4355-a502-d5d2e6e09afa" - "Nf1-/- HEK 293": - description: "[From GFF:] Nf1-/- HEK 293" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=44f9c496-ddd8-4e4b-bddb-6b93f7e04fc2" - "Nf1-/- skin-derived precursor cells": - description: "[From GFF:] Nf1-/- skin-derived precursor cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=15c3bd82-9791-4a53-b6f7-4d23b882a285" - "Nf1Arg681*/+ ES": - description: "[From GFF:] Nf1Arg681*/+ ES" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ff97eee-5c1a-4439-9df6-d1715cbdd189" - "Nf1Arg681*/Arg681* ES": - description: "[From GFF:] Nf1Arg681*/Arg681* ES" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=70c1e3f6-751f-49e4-aa47-e3bea4aeac43" - "Nf1Arg681*/Arg681* MEFs": - description: "[From GFF:] Nf1Arg681*/Arg681* MEFs" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47f50ef0-8d59-430d-9d05-7df1a4f41c3b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84d5c1ae-b82b-4b80-ab7a-3884c8efafda OSW: - description: "Mutation of NF1, p.Asn58fs (c.167delA), Homozygous (PubMed=31175136)." + description: Mutation of NF1, p.Asn58fs (c.167delA), Homozygous (PubMed=31175136). meaning: rrid:CVCL_0B19 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a62af66-384d-419b-b8ac-f4d381b85942" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a62af66-384d-419b-b8ac-f4d381b85942 PEO4: - description: "Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (CelloPub=CLPUB00667, DepMap)." + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp + (c.478A>T), Homozygous (CelloPub=CLPUB00667, DepMap). meaning: rrid:CVCL_2690 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb0770ce-7733-41e5-8ca3-d1abfbe44a31" - "PEO4-iPSC-OSKM-03": - description: "Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb0770ce-7733-41e5-8ca3-d1abfbe44a31 + PEO4-iPSC-OSKM-03: + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp + (c.478A>T), Homozygous (from parent cell line). meaning: rrid:CVCL_B7JI - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7126593e-4b96-40a5-9ff4-d41b81fbba4c" - "PEO4-iPSC-OSKM-05": - description: "Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7126593e-4b96-40a5-9ff4-d41b81fbba4c + PEO4-iPSC-OSKM-05: + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp + (c.478A>T), Homozygous (from parent cell line). meaning: rrid:CVCL_B7JJ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f103987e-5196-440e-a6ba-53d39305c714" - "PK-1": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap)." - meaning: rrid:CVCL_4717 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53f296e1-638f-44af-8a6f-e9dd601586b0" - "PK-45H": - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (DepMap)." - meaning: rrid:CVCL_6748 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e18db26-a0c8-4418-8c64-a73d3fa7e8af" - "PK-59": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap)." - meaning: rrid:CVCL_4897 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f1d08c5-73a8-47e5-b113-031c6a55316d" - "PNET-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f103987e-5196-440e-a6ba-53d39305c714 + PNET-1: meaning: rrid:CVCL_A5PP - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65a74b6e-bede-4228-a43d-3939f2c6311a" - "PNET-2": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65a74b6e-bede-4228-a43d-3939f2c6311a + PNET-2: meaning: rrid:CVCL_4432 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45cf8733-b0c2-433e-b5fc-abd3a0748b79" - "PaTu 8902": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1845 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ead740e0-7ced-4d3c-b411-207cd8f7ae74" - "Panc 02.03": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1633 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21237832-d6ba-422e-80ec-36a3ae6d7c7a" - "Panc 03.27": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1635 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2acf94e6-185b-4717-8f04-71ac8b6d62e3" - "Panc 04.03": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1636 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177e4c5c-f9dd-4695-a3ca-fb9205aae724" - "Panc 08.13": - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=9612602, ATCC)." - meaning: rrid:CVCL_1638 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d861eabe-95d4-47d7-bbb9-be13f7db26f6" - "Panc 10.05": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1639 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf2cfa90-a8cd-4ae4-ad5d-2ab86eddd313" - "QGP-1": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=21607521, PubMed=29444910, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_3143 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3b46e6a-030c-4f5e-8d86-d0f540d31edb" - QQ0588: - description: "An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line" - meaning: rrid:CVCL_8Y66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53c871d3-6f75-49a6-aa73-42d0ead2298b" - "RCM-1": - description: "2 alleles of G12V mutation in KRAS gene. Mutation, KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1648 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c003a385-2de1-4ee8-a2d3-212bb746dac9" - "RERF-LC-Ad2": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (DepMap)." - meaning: rrid:CVCL_1652 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6cb07c1-218d-4762-90d9-4de228447635" - "RG-137": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B564 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b9d9f06-2918-490e-a783-1655c757d922" - "RG-138": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B565 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6e0a7ed-94f6-42e1-9700-6cafcb00f426" - "RG-139": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B566 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1dc0e42-68f8-4650-89ac-37a6acdeb10e" - "RG-140": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B567 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2fe9632c-b6db-443f-a512-4b2523a470e0" - "RG-141": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304)." - meaning: rrid:CVCL_B568 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aba67450-594d-422b-a7fe-6c69a882b859" - "RG-235": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA." - meaning: rrid:CVCL_B653 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=978d317f-f1d6-4039-a2f5-f0787adf589a" - "RG-315": - description: "Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T); Heterozygous (ISCR)." - meaning: rrid:CVCL_B721 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0360411b-59dd-457a-ab6f-38a9182c425e" - S462: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_1Y70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2fb9f7e-ea11-404f-8c0c-c9dc36367f2d" - S462.TY: - description: "MPNST tumor cell line from an NF1 patient, created by passaging S462 cell line in mice as xenografts." - meaning: rrid:CVCL_JK02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6a101aa-9ca8-4191-9b43-eddf327ea48b" - S462s: - description: "Human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c655750-7b47-4cd1-bc5d-2bc6246f5e26" - S462sp: - description: "MPNST-derived cell line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ab6c976-dbd3-4616-9911-23f4981fa5c5" - S520: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_AX35 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0a60dec-8ead-43c5-abc2-b06b89dd20cd" - "SHG-140": - description: "Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T), Homozygous (PubMed=33391433)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45cf8733-b0c2-433e-b5fc-abd3a0748b79 + SHG-140: + description: Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T), + Homozygous (PubMed=33391433). meaning: rrid:CVCL_A0XC - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa66c45-c7b1-4a85-bfe9-79bb0a1334a7" - "SHP-77": - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1693 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b177ff32-b33c-4327-8862-e5b23994b502" - "SIGTR ES cell line AA0320": - description: "High throughput gene trapping was performed by inserting a gene trap vector containing a splice-acceptor sequence upstream of a reporter gene, β-geo (a fusion of β-galactosidase and neomycin phosphotransferase II), into an intronic or coding region of genomic DNA. The resulting insertional mutation creates a fusion transcript containing sequences from exons upstream of the insertion joined to the β-geo marker, allowing cell lines where the vector has successfully interrupted a gene to be identified." - meaning: "rrid:MMRRC_025689-UCD" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8a75443-a92f-45f7-9290-0669405e2e9c" - "SJNB-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa66c45-c7b1-4a85-bfe9-79bb0a1334a7 + SJNB-1: meaning: rrid:CVCL_8812 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e1d0a02-22cc-489a-851c-c7b9955a6270" - "SJNB-10": - description: "Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e1d0a02-22cc-489a-851c-c7b9955a6270 + SJNB-10: + description: Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465). meaning: rrid:CVCL_1441 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7bcdcae-52d3-4bc5-af24-243483588ee5" - "SJNB-12": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7bcdcae-52d3-4bc5-af24-243483588ee5 + SJNB-12: meaning: rrid:CVCL_1442 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6bcc8ec-3169-4e4f-afbb-fbca2658007c" - "SJNB-13": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6bcc8ec-3169-4e4f-afbb-fbca2658007c + SJNB-13: meaning: rrid:CVCL_1443 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1785a08d-ce83-45f6-bba8-68f4b0d3514c" - "SJNB-14": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1785a08d-ce83-45f6-bba8-68f4b0d3514c + SJNB-14: meaning: rrid:CVCL_1444 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae35c72c-7fd9-463b-9b0d-fb4670ccf05e" - "SJNB-16": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae35c72c-7fd9-463b-9b0d-fb4670ccf05e + SJNB-16: meaning: rrid:CVCL_8815 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce47dba5-1303-4253-af99-3e16cc14a341" - "SJNB-19": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce47dba5-1303-4253-af99-3e16cc14a341 + SJNB-19: meaning: rrid:CVCL_8817 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d45b694e-00fc-481a-96d5-c081941d14f5" - "SJNB-2": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d45b694e-00fc-481a-96d5-c081941d14f5 + SJNB-2: meaning: rrid:CVCL_8818 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=965771a4-c863-4e89-a9db-d160d1e4c5e5" - "SJNB-3": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=965771a4-c863-4e89-a9db-d160d1e4c5e5 + SJNB-3: meaning: rrid:CVCL_8820 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c87d24ac-439e-404a-9a43-6110c497599e" - "SJNB-4": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c87d24ac-439e-404a-9a43-6110c497599e + SJNB-4: meaning: rrid:CVCL_8821 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1d2aa58f-2aaa-44ca-96e0-e37231052451" - "SJNB-5": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1d2aa58f-2aaa-44ca-96e0-e37231052451 + SJNB-5: meaning: rrid:CVCL_8822 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9634dff-4e4e-4cd9-bfe9-3d23e7d40583" - "SJNB-6": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9634dff-4e4e-4cd9-bfe9-3d23e7d40583 + SJNB-6: meaning: rrid:CVCL_8823 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9c45c5d-8707-437e-ab75-a8135e95b45d" - "SJNB-7": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9c45c5d-8707-437e-ab75-a8135e95b45d + SJNB-7: meaning: rrid:CVCL_8824 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e6aae84-e57c-4c1d-9ce7-24a03026b435" - "SJNB-8": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e6aae84-e57c-4c1d-9ce7-24a03026b435 + SJNB-8: meaning: rrid:CVCL_8825 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=742d8193-6e25-4f0f-adc7-5dc881727673" - "SJNB-9": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=742d8193-6e25-4f0f-adc7-5dc881727673 + SJNB-9: meaning: rrid:CVCL_8826 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abfc2e7c-0d28-422f-9973-74b5fb66b402" - "SK-CO-1": - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0626 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e7d6716-540f-4206-a32e-4b7ca4b4c53e" - "SK-LU-1": - description: "1 alleles of G12D mutation in KRAS gene. Cell line positive for alternative lengthening of telomeres (ALT+). Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=1855224, PubMed=12068308, PubMed=12794755, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0629 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=903d9857-0c45-4817-a8d6-b43490a3fbcb" - "SK-MEL-105": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abfc2e7c-0d28-422f-9973-74b5fb66b402 + SK-MEL-105: meaning: rrid:CVCL_6070 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b6cfa68c-9b94-4c77-8ef2-6753e595ea59" - "SK-MEL-109": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b6cfa68c-9b94-4c77-8ef2-6753e595ea59 + SK-MEL-109: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6073 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c8c2065-4781-4275-88bc-c300d6fce45a" - "SK-MEL-11": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c8c2065-4781-4275-88bc-c300d6fce45a + SK-MEL-11: meaning: rrid:CVCL_D702 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be7ecfd3-30cc-4ed3-b923-92ad62970441" - "SK-MEL-110": - description: "Mutation of KRAS, p.Glu63Lys (c.187G>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be7ecfd3-30cc-4ed3-b923-92ad62970441 + SK-MEL-110: + description: Mutation of KRAS, p.Glu63Lys (c.187G>A), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_3875 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e1a6df94-feec-421c-a865-12d27212fd62" - "SK-MEL-113": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e1a6df94-feec-421c-a865-12d27212fd62 + SK-MEL-113: meaning: rrid:CVCL_6074 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eabae967-3d0b-4d26-848f-83e0b7d3f646" - "SK-MEL-117": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eabae967-3d0b-4d26-848f-83e0b7d3f646 + SK-MEL-117: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6075 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42c32d24-0d9e-48f9-84fe-6b68ea76d4b3" - "SK-MEL-118": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42c32d24-0d9e-48f9-84fe-6b68ea76d4b3 + SK-MEL-118: meaning: rrid:CVCL_6076 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a92babaf-c310-4c73-8d35-c8942a60272c" - "SK-MEL-119": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=10766161, PubMed=15009714, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a92babaf-c310-4c73-8d35-c8942a60272c + SK-MEL-119: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=10766161, PubMed=15009714, PubMed=24576830). meaning: rrid:CVCL_6077 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=67795a20-8d41-4a1c-a79d-ee6b4e02b00f" - "SK-MEL-12": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=67795a20-8d41-4a1c-a79d-ee6b4e02b00f + SK-MEL-12: meaning: rrid:CVCL_6021 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a739a670-527d-4be6-9e3a-66366b8a5242" - "SK-MEL-127": - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a739a670-527d-4be6-9e3a-66366b8a5242 + SK-MEL-127: + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6078 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08684da1-cd81-4616-baef-5b37ee641eb3" - "SK-MEL-13": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08684da1-cd81-4616-baef-5b37ee641eb3 + SK-MEL-13: meaning: rrid:CVCL_6022 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7765fe-7681-40cb-8a72-6f6d5204985e" - "SK-MEL-130": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7765fe-7681-40cb-8a72-6f6d5204985e + SK-MEL-130: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6080 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e9b741c-b0af-4c12-a1c0-9dd23facb95e" - "SK-MEL-131": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e9b741c-b0af-4c12-a1c0-9dd23facb95e + SK-MEL-131: meaning: rrid:CVCL_6081 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=091b8721-27f6-4a7b-ab85-833aa57a61c3" - "SK-MEL-133": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=091b8721-27f6-4a7b-ab85-833aa57a61c3 + SK-MEL-133: meaning: rrid:CVCL_6082 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=896db229-428a-447b-b37d-b2b7c405545d" - "SK-MEL-146": - description: "Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=896db229-428a-447b-b37d-b2b7c405545d + SK-MEL-146: + description: Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_6085 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=80e1cac7-712d-4333-9d09-27e8cce3d46d" - "SK-MEL-15": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=80e1cac7-712d-4333-9d09-27e8cce3d46d + SK-MEL-15: meaning: rrid:CVCL_6964 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d269f40c-b3e7-4dc7-9c40-28ba1f9711cf" - "SK-MEL-153": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d269f40c-b3e7-4dc7-9c40-28ba1f9711cf + SK-MEL-153: meaning: rrid:CVCL_6087 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be99815b-bab0-49e1-b281-3163d4c34be5" - "SK-MEL-161": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be99815b-bab0-49e1-b281-3163d4c34be5 + SK-MEL-161: meaning: rrid:CVCL_6088 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615ef245-4753-4a2d-9e37-013f5c0411c4" - "SK-MEL-170": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615ef245-4753-4a2d-9e37-013f5c0411c4 + SK-MEL-170: meaning: rrid:CVCL_6089 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3e11e0d-a7bf-491e-badd-88404b403caf" - "SK-MEL-174": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3e11e0d-a7bf-491e-badd-88404b403caf + SK-MEL-174: meaning: rrid:CVCL_6091 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54970293-b923-4058-baee-abea1f0154e8" - "SK-MEL-176": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54970293-b923-4058-baee-abea1f0154e8 + SK-MEL-176: meaning: rrid:CVCL_6092 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e712f46a-4e8d-48bd-87e6-1329b358e178" - "SK-MEL-178": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e712f46a-4e8d-48bd-87e6-1329b358e178 + SK-MEL-178: meaning: rrid:CVCL_6093 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3ad8165-42aa-4e9b-8403-3df16139b535" - "SK-MEL-181": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3ad8165-42aa-4e9b-8403-3df16139b535 + SK-MEL-181: meaning: rrid:CVCL_6094 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a71bce03-eef0-422c-b327-6c79cf634bbe" - "SK-MEL-182": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a71bce03-eef0-422c-b327-6c79cf634bbe + SK-MEL-182: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6095 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0b3d75cd-ed20-4fe4-b588-317a870ca687" - "SK-MEL-186": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0b3d75cd-ed20-4fe4-b588-317a870ca687 + SK-MEL-186: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6096 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2d5cbfd-18e1-4755-b2e9-1d3df322aa60" - "SK-MEL-188": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2d5cbfd-18e1-4755-b2e9-1d3df322aa60 + SK-MEL-188: description: Pigmented. meaning: rrid:CVCL_6098 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2df52df1-44ae-4897-afc9-cbbc997a73ca" - "SK-MEL-190": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2df52df1-44ae-4897-afc9-cbbc997a73ca + SK-MEL-190: meaning: rrid:CVCL_6099 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1dff78ed-20a6-4df8-ba2c-4979eef85cf8" - "SK-MEL-191": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1dff78ed-20a6-4df8-ba2c-4979eef85cf8 + SK-MEL-191: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6100 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=446e95ac-2716-4a3b-8294-74f1a3ba38b0" - "SK-MEL-196": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=446e95ac-2716-4a3b-8294-74f1a3ba38b0 + SK-MEL-196: meaning: rrid:CVCL_6102 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3967dcb7-a32f-4437-bc30-21e9d1b27d5b" - "SK-MEL-199": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3967dcb7-a32f-4437-bc30-21e9d1b27d5b + SK-MEL-199: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6104 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=545a4d43-e5ec-4989-9f7f-f5274248072c" - "SK-MEL-200": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=545a4d43-e5ec-4989-9f7f-f5274248072c + SK-MEL-200: meaning: rrid:CVCL_6105 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4ce28266-8fbc-48f1-8e17-35719865102d" - "SK-MEL-202": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4ce28266-8fbc-48f1-8e17-35719865102d + SK-MEL-202: meaning: rrid:CVCL_6106 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=389f4f77-8faf-46b8-9ae2-91e26844bfc3" - "SK-MEL-205": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=389f4f77-8faf-46b8-9ae2-91e26844bfc3 + SK-MEL-205: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6107 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d557680-ae5b-4345-8742-d0cc4a6318a2" - "SK-MEL-207": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d557680-ae5b-4345-8742-d0cc4a6318a2 + SK-MEL-207: meaning: rrid:CVCL_6108 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f02bdc8-5936-495a-af4b-0b94b14dfe2c" - "SK-MEL-208": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f02bdc8-5936-495a-af4b-0b94b14dfe2c + SK-MEL-208: meaning: rrid:CVCL_6109 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8801096-624b-463a-90b3-143a4dd8d504" - "SK-MEL-209": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8801096-624b-463a-90b3-143a4dd8d504 + SK-MEL-209: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6110 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a56209e-d090-4f66-bf8c-66eafa35bcfe" - "SK-MEL-21": - description: "Very highly pigmented. Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a56209e-d090-4f66-bf8c-66eafa35bcfe + SK-MEL-21: + description: Very highly pigmented. Mutation of NRAS, p.Gln61Lys (c.181C>A), + Unspecified zygosity (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_3877 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4d34543-1c7d-4c58-adf7-3f60a1df91d4" - "SK-MEL-210-3": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4d34543-1c7d-4c58-adf7-3f60a1df91d4 + SK-MEL-210-3: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_D772 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f23a835-e46f-4e7e-9643-1ad7264ca35d" - "SK-MEL-215-1": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f23a835-e46f-4e7e-9643-1ad7264ca35d + SK-MEL-215-1: meaning: rrid:CVCL_U911 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2805574-fdd3-40d5-bf01-ed5e4c32498f" - "SK-MEL-217": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2805574-fdd3-40d5-bf01-ed5e4c32498f + SK-MEL-217: meaning: rrid:CVCL_6111 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f4ac84fa-aadd-4a36-9aca-d1bc1e7a4c3e" - "SK-MEL-22": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f4ac84fa-aadd-4a36-9aca-d1bc1e7a4c3e + SK-MEL-22: meaning: rrid:CVCL_6026 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d53de27-93dd-4421-8612-2e3402106ee7" - "SK-MEL-222": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d53de27-93dd-4421-8612-2e3402106ee7 + SK-MEL-222: meaning: rrid:CVCL_6112 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46b0bf61-f688-43b7-97f6-29f3462b9313" - "SK-MEL-227": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46b0bf61-f688-43b7-97f6-29f3462b9313 + SK-MEL-227: meaning: rrid:CVCL_6113 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=210a3450-b6ff-4a15-b6b7-415d96246d1b" - "SK-MEL-228": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=210a3450-b6ff-4a15-b6b7-415d96246d1b + SK-MEL-228: meaning: rrid:CVCL_6114 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de2d02b5-5406-488f-bd57-03efcec737a9" - "SK-MEL-229": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de2d02b5-5406-488f-bd57-03efcec737a9 + SK-MEL-229: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6115 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05280043-5ac8-4427-9e19-f53c8efd260e" - "SK-MEL-23": - description: "Very highly pigmented." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05280043-5ac8-4427-9e19-f53c8efd260e + SK-MEL-23: + description: Very highly pigmented. meaning: rrid:CVCL_6027 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d6345dc-0415-4afe-965d-683c2f7fb6f3" - "SK-MEL-230": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d6345dc-0415-4afe-965d-683c2f7fb6f3 + SK-MEL-230: meaning: rrid:CVCL_6116 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=318b6745-af78-435e-9bd2-83fa22cf8c7b" - "SK-MEL-232": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=318b6745-af78-435e-9bd2-83fa22cf8c7b + SK-MEL-232: meaning: rrid:CVCL_6117 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a689488c-6aa3-4c3e-ab74-a58348944338" - "SK-MEL-233": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a689488c-6aa3-4c3e-ab74-a58348944338 + SK-MEL-233: meaning: rrid:CVCL_6118 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f927ed06-7d0e-43af-9031-dbedfc2c42d3" - "SK-MEL-234": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f927ed06-7d0e-43af-9031-dbedfc2c42d3 + SK-MEL-234: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6119 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7935406-82be-4ed6-82fe-0f387439cd4f" - "SK-MEL-237": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7935406-82be-4ed6-82fe-0f387439cd4f + SK-MEL-237: meaning: rrid:CVCL_6120 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efd49881-3065-4fff-a296-8dc1ea2f63b7" - "SK-MEL-238": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efd49881-3065-4fff-a296-8dc1ea2f63b7 + SK-MEL-238: meaning: rrid:CVCL_6121 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24f0992a-00ed-4a1f-b8f5-72e42cb8556d" - "SK-MEL-239": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24f0992a-00ed-4a1f-b8f5-72e42cb8556d + SK-MEL-239: meaning: rrid:CVCL_6122 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0128a62c-13f8-485e-802d-c4c3e1ef7905" - "SK-MEL-243": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0128a62c-13f8-485e-802d-c4c3e1ef7905 + SK-MEL-243: meaning: rrid:CVCL_6123 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4386a81c-a396-4600-a972-2b993cb9af0e" - "SK-MEL-244": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4386a81c-a396-4600-a972-2b993cb9af0e + SK-MEL-244: meaning: rrid:CVCL_6124 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=363d82b8-97ac-429a-b9d6-e195fb764e5c" - "SK-MEL-246": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=363d82b8-97ac-429a-b9d6-e195fb764e5c + SK-MEL-246: meaning: rrid:CVCL_6126 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4adf5880-df01-4b08-aed3-11366ca77f42" - "SK-MEL-252": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4adf5880-df01-4b08-aed3-11366ca77f42 + SK-MEL-252: meaning: rrid:CVCL_6127 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b1e67f2-410d-4a22-822d-c812003f6312" - "SK-MEL-256": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b1e67f2-410d-4a22-822d-c812003f6312 + SK-MEL-256: meaning: rrid:CVCL_6128 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31d0179a-4cd5-4454-a035-ef02f0ef284b" - "SK-MEL-264": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31d0179a-4cd5-4454-a035-ef02f0ef284b + SK-MEL-264: meaning: rrid:CVCL_6131 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ff17bb4d-4cb0-4366-8d6b-e59a7ad73837" - "SK-MEL-265": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ff17bb4d-4cb0-4366-8d6b-e59a7ad73837 + SK-MEL-265: meaning: rrid:CVCL_6132 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c7aa452-e44e-48b4-b57e-f0f11493c389" - "SK-MEL-266": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c7aa452-e44e-48b4-b57e-f0f11493c389 + SK-MEL-266: meaning: rrid:CVCL_6133 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffc1bc88-d5ec-4b2f-a36b-6052f9d736b7" - "SK-MEL-267": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffc1bc88-d5ec-4b2f-a36b-6052f9d736b7 + SK-MEL-267: meaning: rrid:CVCL_6134 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58864ae6-c1da-409e-a473-afbe769e35d0" - "SK-MEL-268": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58864ae6-c1da-409e-a473-afbe769e35d0 + SK-MEL-268: meaning: rrid:CVCL_6135 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a012aa8a-d3ab-4f4b-86dc-61c137f3b6b7" - "SK-MEL-269": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a012aa8a-d3ab-4f4b-86dc-61c137f3b6b7 + SK-MEL-269: meaning: rrid:CVCL_6136 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3edcb81d-31b5-4366-b5ad-69ec792df1c5" - "SK-MEL-27": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3edcb81d-31b5-4366-b5ad-69ec792df1c5 + SK-MEL-27: meaning: rrid:CVCL_6030 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e30707fe-357d-4aa8-92e9-8f2db981ef78" - "SK-MEL-271": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e30707fe-357d-4aa8-92e9-8f2db981ef78 + SK-MEL-271: meaning: rrid:CVCL_6137 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3b2a72b-66a5-4fcd-9200-4442c5c51a69" - "SK-MEL-272": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3b2a72b-66a5-4fcd-9200-4442c5c51a69 + SK-MEL-272: meaning: rrid:CVCL_6138 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4af69cf3-041f-46d0-8b20-cd5170ce42a7" - "SK-MEL-275": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4af69cf3-041f-46d0-8b20-cd5170ce42a7 + SK-MEL-275: meaning: rrid:CVCL_6139 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3571655-7dfb-4364-9d61-aebe2ae4039e" - "SK-MEL-276": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3571655-7dfb-4364-9d61-aebe2ae4039e + SK-MEL-276: meaning: rrid:CVCL_6140 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7c386a0-ee01-4ad2-9772-1c29715e26a3" - "SK-MEL-279": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7c386a0-ee01-4ad2-9772-1c29715e26a3 + SK-MEL-279: meaning: rrid:CVCL_6141 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5176605-b22b-45d6-b636-2be6faff0a13" - "SK-MEL-282": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5176605-b22b-45d6-b636-2be6faff0a13 + SK-MEL-282: meaning: rrid:CVCL_6143 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c81c271-14ab-4f29-b006-b2a71dce3009" - "SK-MEL-283": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c81c271-14ab-4f29-b006-b2a71dce3009 + SK-MEL-283: meaning: rrid:CVCL_6144 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=533ec9c8-8391-4979-9b39-e65cef5f9423" - "SK-MEL-284": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=533ec9c8-8391-4979-9b39-e65cef5f9423 + SK-MEL-284: meaning: rrid:CVCL_6145 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06aaab7a-7e1e-4ad0-b4c2-14245c60a927" - "SK-MEL-285": - description: "Mutation of KRAS, p.Gly12Cys (c.34G>T), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06aaab7a-7e1e-4ad0-b4c2-14245c60a927 + SK-MEL-285: + description: Mutation of KRAS, p.Gly12Cys (c.34G>T), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_6146 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=62654a64-d223-4d52-81e1-6869e071bc52" - "SK-MEL-301": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=62654a64-d223-4d52-81e1-6869e071bc52 + SK-MEL-301: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6147 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22c9daa2-d3bb-4e9d-b615-45fdd7506ae5" - "SK-MEL-304": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22c9daa2-d3bb-4e9d-b615-45fdd7506ae5 + SK-MEL-304: meaning: rrid:CVCL_6148 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b24851b4-c7b9-4265-b3dd-8cdd6ff1df6b" - "SK-MEL-306": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b24851b4-c7b9-4265-b3dd-8cdd6ff1df6b + SK-MEL-306: meaning: rrid:CVCL_6149 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c89cb4de-6160-452d-b8f9-054250e25207" - "SK-MEL-307": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c89cb4de-6160-452d-b8f9-054250e25207 + SK-MEL-307: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6150 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6c7e09f2-b4a4-4e21-a346-8d46c7815a25" - "SK-MEL-309B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6c7e09f2-b4a4-4e21-a346-8d46c7815a25 + SK-MEL-309B: meaning: rrid:CVCL_U912 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64f2ff80-3b84-4d42-985a-c7290ffb1ed3" - "SK-MEL-313": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64f2ff80-3b84-4d42-985a-c7290ffb1ed3 + SK-MEL-313: meaning: rrid:CVCL_1T59 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ebc58516-eb4c-4b8a-ac75-1ad3cc9ec258" - "SK-MEL-315-02": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ebc58516-eb4c-4b8a-ac75-1ad3cc9ec258 + SK-MEL-315-02: meaning: rrid:CVCL_E090 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b05001f1-b471-4d98-925b-521c4cbaf31d" - "SK-MEL-315-05": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b05001f1-b471-4d98-925b-521c4cbaf31d + SK-MEL-315-05: meaning: rrid:CVCL_E092 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9906bf3-21a5-4cef-9119-02b25b4a556f" - "SK-MEL-316": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9906bf3-21a5-4cef-9119-02b25b4a556f + SK-MEL-316: meaning: rrid:CVCL_6151 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=231c785d-ad45-4395-b7b9-64c734a79fd1" - "SK-MEL-318": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=231c785d-ad45-4395-b7b9-64c734a79fd1 + SK-MEL-318: meaning: rrid:CVCL_1T60 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05799982-53b2-4872-990d-9d79fdfcae38" - "SK-MEL-32": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05799982-53b2-4872-990d-9d79fdfcae38 + SK-MEL-32: meaning: rrid:CVCL_6032 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423ba382-0958-4015-a4f3-c01f29442df1" - "SK-MEL-321A": - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423ba382-0958-4015-a4f3-c01f29442df1 + SK-MEL-321A: + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_D771 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=11b6440f-fe1b-49be-835e-e3d063daba0e" - "SK-MEL-321B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=11b6440f-fe1b-49be-835e-e3d063daba0e + SK-MEL-321B: meaning: rrid:CVCL_E089 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=145c4d7f-81de-436c-801b-15cc2298895d" - "SK-MEL-323": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=145c4d7f-81de-436c-801b-15cc2298895d + SK-MEL-323: meaning: rrid:CVCL_6152 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5133ef-e87d-4026-a9b5-56ece87fde75" - "SK-MEL-325": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5133ef-e87d-4026-a9b5-56ece87fde75 + SK-MEL-325: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6153 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5cd8c18c-d03e-4129-913a-ab50484aa8ef" - "SK-MEL-326": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5cd8c18c-d03e-4129-913a-ab50484aa8ef + SK-MEL-326: meaning: rrid:CVCL_6154 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84aa6e1a-1d68-4923-beea-af84d7593a3e" - "SK-MEL-330": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84aa6e1a-1d68-4923-beea-af84d7593a3e + SK-MEL-330: meaning: rrid:CVCL_6155 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6aef573-0840-4920-b66a-0b361a22d92b" - "SK-MEL-332": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6aef573-0840-4920-b66a-0b361a22d92b + SK-MEL-332: meaning: rrid:CVCL_1T61 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a01e27d8-a50e-49c1-9a5d-5202460b94c2" - "SK-MEL-334": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a01e27d8-a50e-49c1-9a5d-5202460b94c2 + SK-MEL-334: meaning: rrid:CVCL_6156 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a065ee27-ac39-4fe2-82a2-8c92011f6b23" - "SK-MEL-339": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a065ee27-ac39-4fe2-82a2-8c92011f6b23 + SK-MEL-339: meaning: rrid:CVCL_6157 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b58976e-5983-411b-b193-75a16c63dfb9" - "SK-MEL-346": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b58976e-5983-411b-b193-75a16c63dfb9 + SK-MEL-346: meaning: rrid:CVCL_6159 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e465de74-8162-4b07-a5b9-2004fee28873" - "SK-MEL-35": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e465de74-8162-4b07-a5b9-2004fee28873 + SK-MEL-35: meaning: rrid:CVCL_6034 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24a85352-2025-4ba8-a8e4-9db6150c35ea" - "SK-MEL-351": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24a85352-2025-4ba8-a8e4-9db6150c35ea + SK-MEL-351: meaning: rrid:CVCL_6160 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce3b913-11dc-4827-8cd8-46b4fae21993" - "SK-MEL-359": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce3b913-11dc-4827-8cd8-46b4fae21993 + SK-MEL-359: meaning: rrid:CVCL_6161 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce242fc6-c98c-47fb-ab26-876ad418a8dc" - "SK-MEL-36": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce242fc6-c98c-47fb-ab26-876ad418a8dc + SK-MEL-36: meaning: rrid:CVCL_6035 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20fd4d84-bcf4-4016-84e6-904c8ab5d931" - "SK-MEL-364": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20fd4d84-bcf4-4016-84e6-904c8ab5d931 + SK-MEL-364: meaning: rrid:CVCL_6162 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86d7407c-c680-4866-a5c2-bc77e0488c6f" - "SK-MEL-366": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86d7407c-c680-4866-a5c2-bc77e0488c6f + SK-MEL-366: meaning: rrid:CVCL_6163 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46ea3bf7-34ca-48ab-8e55-e2eb1221c741" - "SK-MEL-367": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46ea3bf7-34ca-48ab-8e55-e2eb1221c741 + SK-MEL-367: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6164 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13938786-687b-4476-845f-04a0533aac60" - "SK-MEL-369": - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13938786-687b-4476-845f-04a0533aac60 + SK-MEL-369: + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6165 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=153a917d-42f2-4fa3-af4a-fa2d9aeea185" - "SK-MEL-380": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=153a917d-42f2-4fa3-af4a-fa2d9aeea185 + SK-MEL-380: meaning: rrid:CVCL_6166 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49c46106-2a7b-420f-ab36-3501ee7aede4" - "SK-MEL-381": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49c46106-2a7b-420f-ab36-3501ee7aede4 + SK-MEL-381: meaning: rrid:CVCL_6167 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee3cbd77-c4f4-46e3-b4c3-0bf945215117" - "SK-MEL-39": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee3cbd77-c4f4-46e3-b4c3-0bf945215117 + SK-MEL-39: meaning: rrid:CVCL_6036 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615c7563-d62b-4d4e-9852-6ba6ee5e1bb2" - "SK-MEL-390": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615c7563-d62b-4d4e-9852-6ba6ee5e1bb2 + SK-MEL-390: meaning: rrid:CVCL_6168 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1829be6d-fdc2-44eb-a1d1-32678faeb6c7" - "SK-MEL-391": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1829be6d-fdc2-44eb-a1d1-32678faeb6c7 + SK-MEL-391: meaning: rrid:CVCL_1T62 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86212d03-fe40-45e2-8fbf-587cd052b194" - "SK-MEL-393": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86212d03-fe40-45e2-8fbf-587cd052b194 + SK-MEL-393: meaning: rrid:CVCL_1T63 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9e7f25d9-7b2b-4272-9c80-dfaf030f0b36" - "SK-MEL-394": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9e7f25d9-7b2b-4272-9c80-dfaf030f0b36 + SK-MEL-394: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_1T64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3fa847e6-2be0-4b0d-bdab-630aaf9a10d4" - "SK-MEL-398": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3fa847e6-2be0-4b0d-bdab-630aaf9a10d4 + SK-MEL-398: meaning: rrid:CVCL_1T65 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a4ec3ce-a757-43ad-9c54-0999f94c4a10" - "SK-MEL-40": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a4ec3ce-a757-43ad-9c54-0999f94c4a10 + SK-MEL-40: meaning: rrid:CVCL_6037 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a997c565-7bda-4a81-a7cf-800d1612598e" - "SK-MEL-400": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a997c565-7bda-4a81-a7cf-800d1612598e + SK-MEL-400: meaning: rrid:CVCL_1T66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f4941d-ed79-41f1-9a2a-a494baed6d7b" - "SK-MEL-406": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f4941d-ed79-41f1-9a2a-a494baed6d7b + SK-MEL-406: meaning: rrid:CVCL_1T67 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=935f7b60-4c34-4fc9-a877-ec901f25f162" - "SK-MEL-408": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=935f7b60-4c34-4fc9-a877-ec901f25f162 + SK-MEL-408: meaning: rrid:CVCL_1T68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9a797dc-91ba-4592-bd06-967f5b38124d" - "SK-MEL-41": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9a797dc-91ba-4592-bd06-967f5b38124d + SK-MEL-41: meaning: rrid:CVCL_6038 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae3724e-ba3b-4787-b81e-d62d434a3ac9" - "SK-MEL-410": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae3724e-ba3b-4787-b81e-d62d434a3ac9 + SK-MEL-410: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_1T69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5f60fa1a-e9a7-4e49-a760-d2906ba17851" - "SK-MEL-411": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5f60fa1a-e9a7-4e49-a760-d2906ba17851 + SK-MEL-411: meaning: rrid:CVCL_1T70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cd4f5e0-e110-40ce-98c9-422fda40866e" - "SK-MEL-412Parotid": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cd4f5e0-e110-40ce-98c9-422fda40866e + SK-MEL-412Parotid: meaning: rrid:CVCL_1T71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=159262e3-0f60-4af6-95ff-a3696aa6db9e" - "SK-MEL-413-2": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=159262e3-0f60-4af6-95ff-a3696aa6db9e + SK-MEL-413-2: meaning: rrid:CVCL_1T72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=413969a1-e4c2-4a17-84de-5925d1209ed6" - "SK-MEL-423A": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=413969a1-e4c2-4a17-84de-5925d1209ed6 + SK-MEL-423A: meaning: rrid:CVCL_1T73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ba04cec-c260-462c-b8ce-75536ba04307" - "SK-MEL-423B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ba04cec-c260-462c-b8ce-75536ba04307 + SK-MEL-423B: meaning: rrid:CVCL_1T74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6954af4e-0907-460b-ace8-6f807dc897ea" - "SK-MEL-426": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6954af4e-0907-460b-ace8-6f807dc897ea + SK-MEL-426: meaning: rrid:CVCL_1T75 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20deb6a8-c59e-4f29-8ee8-cd9828191916" - "SK-MEL-427": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20deb6a8-c59e-4f29-8ee8-cd9828191916 + SK-MEL-427: meaning: rrid:CVCL_1T76 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13a298c0-38d6-4945-9afb-a7c3bb11509d" - "SK-MEL-428": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13a298c0-38d6-4945-9afb-a7c3bb11509d + SK-MEL-428: meaning: rrid:CVCL_1T77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d34fb6f1-ec5c-440e-97e9-276088635d67" - "SK-MEL-430": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d34fb6f1-ec5c-440e-97e9-276088635d67 + SK-MEL-430: meaning: rrid:CVCL_1T78 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=17aba291-d856-4625-aad0-077514b14d40" - "SK-MEL-431": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=17aba291-d856-4625-aad0-077514b14d40 + SK-MEL-431: meaning: rrid:CVCL_1T79 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f26dd6bb-0195-4571-98e2-23ec963c86ec" - "SK-MEL-432": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f26dd6bb-0195-4571-98e2-23ec963c86ec + SK-MEL-432: meaning: rrid:CVCL_1T80 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913629f6-cace-496b-acb8-03c97e4ace11" - "SK-MEL-435": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913629f6-cace-496b-acb8-03c97e4ace11 + SK-MEL-435: meaning: rrid:CVCL_1T81 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e528ff6d-23e4-487b-9338-839d2c564a11" - "SK-MEL-439": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e528ff6d-23e4-487b-9338-839d2c564a11 + SK-MEL-439: meaning: rrid:CVCL_1T82 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd531418-d7a3-456f-8473-1e9fd37ed3a5" - "SK-MEL-441": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd531418-d7a3-456f-8473-1e9fd37ed3a5 + SK-MEL-441: meaning: rrid:CVCL_1T83 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4b5d552-0eea-4ff6-b127-6d9a691b5600" - "SK-MEL-444": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4b5d552-0eea-4ff6-b127-6d9a691b5600 + SK-MEL-444: meaning: rrid:CVCL_1T84 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13274e2e-62c6-49ec-92b5-78cafa4cfc73" - "SK-MEL-445": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13274e2e-62c6-49ec-92b5-78cafa4cfc73 + SK-MEL-445: meaning: rrid:CVCL_1T85 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=141f4221-e03d-4b75-a3da-ff8efb3aed02" - "SK-MEL-446": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=141f4221-e03d-4b75-a3da-ff8efb3aed02 + SK-MEL-446: meaning: rrid:CVCL_1T86 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41aea55a-717a-4460-8593-8b55e90937e6" - "SK-MEL-447": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41aea55a-717a-4460-8593-8b55e90937e6 + SK-MEL-447: meaning: rrid:CVCL_1T87 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878e80a7-4f50-4a23-a1e6-155d988962a5" - "SK-MEL-451": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878e80a7-4f50-4a23-a1e6-155d988962a5 + SK-MEL-451: meaning: rrid:CVCL_1T88 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20eba743-3053-4e3c-97fc-10a53023430b" - "SK-MEL-452": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20eba743-3053-4e3c-97fc-10a53023430b + SK-MEL-452: meaning: rrid:CVCL_1T89 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=042e2889-f4e3-4a3a-85d3-cfa860369bff" - "SK-MEL-455": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=042e2889-f4e3-4a3a-85d3-cfa860369bff + SK-MEL-455: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_1T90 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d77460a-3139-4299-a912-04a4b479ab44" - "SK-MEL-457": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d77460a-3139-4299-a912-04a4b479ab44 + SK-MEL-457: meaning: rrid:CVCL_1T91 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc15a768-cae1-4dc4-ae2e-d861db250ff9" - "SK-MEL-459": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc15a768-cae1-4dc4-ae2e-d861db250ff9 + SK-MEL-459: meaning: rrid:CVCL_1T92 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7cae97f-787c-49aa-9e78-a487e3e3547b" - "SK-MEL-462": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7cae97f-787c-49aa-9e78-a487e3e3547b + SK-MEL-462: meaning: rrid:CVCL_1T93 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3b36f15b-02d6-47c8-987a-09ccbc9b6e35" - "SK-MEL-464A": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3b36f15b-02d6-47c8-987a-09ccbc9b6e35 + SK-MEL-464A: meaning: rrid:CVCL_1T94 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0e8f539b-8704-47c8-a4c4-7402602d0445" - "SK-MEL-464B": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0e8f539b-8704-47c8-a4c4-7402602d0445 + SK-MEL-464B: meaning: rrid:CVCL_1T95 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7440661f-af81-486a-9687-cf6a72d6fd82" - "SK-MEL-479": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7440661f-af81-486a-9687-cf6a72d6fd82 + SK-MEL-479: meaning: rrid:CVCL_1T96 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9612b172-8d91-4524-aa18-7cbe903c7f1b" - "SK-MEL-481": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9612b172-8d91-4524-aa18-7cbe903c7f1b + SK-MEL-481: meaning: rrid:CVCL_1T97 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed77fdc9-b80b-4817-8f86-a01fa5b141cc" - "SK-MEL-483": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed77fdc9-b80b-4817-8f86-a01fa5b141cc + SK-MEL-483: meaning: rrid:CVCL_1T98 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8f27d0-385b-4dc1-82e8-60a456eff3b2" - "SK-MEL-495": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8f27d0-385b-4dc1-82e8-60a456eff3b2 + SK-MEL-495: meaning: rrid:CVCL_1T99 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fa9c1a3-1945-45b1-a9f1-9edb3afd569c" - "SK-MEL-498": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fa9c1a3-1945-45b1-a9f1-9edb3afd569c + SK-MEL-498: meaning: rrid:CVCL_1U00 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce4f80b9-50a2-400c-bd0f-1a1df82931b7" - "SK-MEL-506": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce4f80b9-50a2-400c-bd0f-1a1df82931b7 + SK-MEL-506: meaning: rrid:CVCL_1U01 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=78d23c04-59b6-4532-910a-40cbf8b4d702" - "SK-MEL-507": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=78d23c04-59b6-4532-910a-40cbf8b4d702 + SK-MEL-507: meaning: rrid:CVCL_1U02 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee56490c-9c27-4952-b001-230e572cb108" - "SK-MEL-509": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee56490c-9c27-4952-b001-230e572cb108 + SK-MEL-509: meaning: rrid:CVCL_1U03 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1e0094a-ce3a-4505-8d4d-426adf6ec84e" - "SK-MEL-513": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1e0094a-ce3a-4505-8d4d-426adf6ec84e + SK-MEL-513: meaning: rrid:CVCL_1U04 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=29590580-da13-41b2-a8d3-bd1a2b198f28" - "SK-MEL-524": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=29590580-da13-41b2-a8d3-bd1a2b198f28 + SK-MEL-524: meaning: rrid:CVCL_1U05 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1eeb831e-3fd4-4d88-9384-717b7dcc20d8" - "SK-MEL-529": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1eeb831e-3fd4-4d88-9384-717b7dcc20d8 + SK-MEL-529: meaning: rrid:CVCL_1U06 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ccd7e8d-f5b2-4e2b-8f21-8b982d8921d6" - "SK-MEL-534": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ccd7e8d-f5b2-4e2b-8f21-8b982d8921d6 + SK-MEL-534: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_1U07 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7515b60c-dc11-4786-b3aa-fd7a8f5397f1" - "SK-MEL-538": - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7515b60c-dc11-4786-b3aa-fd7a8f5397f1 + SK-MEL-538: + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=24576830). meaning: rrid:CVCL_1U08 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e2a83d29-7938-4a12-ae21-75b4dbbff7ac" - "SK-MEL-64": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e2a83d29-7938-4a12-ae21-75b4dbbff7ac + SK-MEL-64: meaning: rrid:CVCL_6048 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=053cef50-1dee-46f8-b4a9-2881742ff06d" - "SK-MEL-7": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=053cef50-1dee-46f8-b4a9-2881742ff06d + SK-MEL-7: meaning: rrid:CVCL_D854 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3be7fe60-bbb4-497b-9cd1-8b5c7005cb92" - "SK-MEL-73": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3be7fe60-bbb4-497b-9cd1-8b5c7005cb92 + SK-MEL-73: meaning: rrid:CVCL_6053 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a342ec-bfa3-490e-b8b2-51141b588def" - "SK-MEL-75": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a342ec-bfa3-490e-b8b2-51141b588def + SK-MEL-75: meaning: rrid:CVCL_6054 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46c046c5-20ac-4a51-a73a-758f0a881b2a" - "SK-MEL-90": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46c046c5-20ac-4a51-a73a-758f0a881b2a + SK-MEL-90: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=21725359, PubMed=24576830). meaning: rrid:CVCL_6227 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f3abe8b-5048-4e2f-beae-63a437218761" - "SK-N-AS": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f3abe8b-5048-4e2f-beae-63a437218761 + SK-N-AS: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=12068308, + Cosmic-CLP, DepMap). meaning: rrid:CVCL_1700 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cebfdef3-2323-48d9-bfbb-aa704338eabe" - "SK-N-FI": - description: "Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cebfdef3-2323-48d9-bfbb-aa704338eabe + SK-N-FI: + description: Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465). meaning: rrid:CVCL_1702 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c53f612-f254-487d-a545-186fd4e2b856" - "SK-N-SH": - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (Cosmic-CLP, DepMap)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c53f612-f254-487d-a545-186fd4e2b856 + SK-N-SH: + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (Cosmic-CLP, + DepMap). meaning: rrid:CVCL_0531 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb1b960d-bfd7-48d2-b467-c7faf52b4b3a" - "SMBCi003-A": - description: "Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb1b960d-bfd7-48d2-b467-c7faf52b4b3a + SMBCi003-A: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous + (PubMed=32554297). meaning: rrid:CVCL_YC55 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25e3f6d6-c625-43fc-a1ed-c267bba685f1" - "SMBCi003-B": - description: "Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25e3f6d6-c625-43fc-a1ed-c267bba685f1 + SMBCi003-B: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous + (PubMed=32554297). meaning: rrid:CVCL_YC56 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0361ea84-13bb-4f90-8f24-bbd01a81801e" - "SMBCi003-C": - description: "Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (from autologous cell lines SMBCi003-A and SMBCi003-B)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0361ea84-13bb-4f90-8f24-bbd01a81801e + SMBCi003-C: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous + (from autologous cell lines SMBCi003-A and SMBCi003-B). meaning: rrid:CVCL_YC57 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08a0f6ee-700b-4df3-94cd-cc414214ca99" - "SNU-407": - description: "1 alleles of G12D mutation in KRAS gene, KRAS codon 12 GGT->GAT. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=10362137, Cosmic-CLP)." - meaning: rrid:CVCL_5058 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a05a7478-548d-4e6b-b7d0-17891a503e06" - "SNU-C2A": - description: "1 alleles of G12D mutation in KRAS gene. Established from a nude mouse xenograft. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap)." - meaning: rrid:CVCL_1709 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c51a1afa-d499-4630-8995-a61c9fd733b1" - "SOX10+ SLC": - description: "Human induced pluripotent stem cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3e07933-db64-48ea-bfa5-ed22a8647770" - "ST88-14": - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_8916 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=202c110b-a5f1-49ab-acdc-e6e33a1c29bb" - "ST88-3": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08a0f6ee-700b-4df3-94cd-cc414214ca99 + ST88-3: meaning: rrid:CVCL_IU70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b368f84e-f38b-4ff0-9458-fe5d8b91122d" - "STR-I-437-NF1": - description: "From: INSERM, France." - meaning: rrid:CVCL_Y599 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01040031-60ba-4da5-96b0-d4a0a2f9131b" - "STR-I-441-NF1": - description: "From: INSERM, France." - meaning: rrid:CVCL_Y600 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1372bf73-291f-48f9-9207-81120a299675" - "STR-I-443-NF1": - description: "From: INSERM, France." - meaning: rrid:CVCL_Y601 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5352596f-7192-473c-85b3-2aeb0fbf8e48" - "STS-26T": - description: "Sporadic MPNST tumor cell line from a non-NF1 patient." - meaning: rrid:CVCL_8917 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9a7997c9-9399-47ed-b44b-5b717be89ba3" - "STSA-1": - description: "Mutation of NF1, p.Met877fs (c.2626dupT), Heterozygous (PubMed=31175136)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b368f84e-f38b-4ff0-9458-fe5d8b91122d + STSA-1: + description: Mutation of NF1, p.Met877fs (c.2626dupT), Heterozygous (PubMed=31175136). meaning: rrid:CVCL_D274 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=203f9103-dd83-4879-8a5c-9d8541ae2267" - SU.86.86: - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Hemizygous (PubMed=11115575)." - meaning: rrid:CVCL_3881 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=69abfb3f-7d1e-4433-b542-909b794dd72f" - SW1463: - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=28683746, ATCC, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1718 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42a7d7eb-f6df-45b8-80fc-242650606a84" - SW1573: - description: "2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, ATCC, Cosmic-CLP)." - meaning: rrid:CVCL_1720 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b600b899-2a05-44bb-bc3a-3359a45fa2f9" - SW1990: - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1723 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d519727-94e9-4f9e-95d3-9227443c03fe" - SW403: - description: "2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0545 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed7ecfd-36d3-4573-8e07-210c6088c3a7" - SW480: - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=20570890, PubMed=24755471, PubMed=28683746, DepMap)." - meaning: rrid:CVCL_0546 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b79f24b-7362-4687-8c66-03bcb6a26ab3" - SW620: - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746)." - meaning: rrid:CVCL_0547 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cf15506-fb63-49a8-b36e-6a28a67b4c6d" - SW837: - description: "2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746)." - meaning: rrid:CVCL_1729 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8a15b9-b7b8-42b7-ae4e-ca3ae1ac0be7" - SW900: - description: "1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, Cosmic-CLP)." - meaning: rrid:CVCL_1731 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=880c525a-f1df-49df-afe5-61ad07304c6a" - "SZ-NF1": - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_YL57 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=33cdb482-618e-4489-87d9-3139cc7c6a49" - "SZ-NF2": - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_YL58 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc2045df-5ebf-4491-b5b1-88d65e59b228" - "SZ-NF4": - description: "Human embryonic stem cell line derived from an embryo with an NF1 mutation." - meaning: rrid:CVCL_YL59 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09c988ab-765a-44ca-b2d7-1957b729208e" - "SZ-NF6": - description: "From: Shaare Zedek Medical Center, The Hebrew University, Jerusalem, Israel., Mutation of NF1, c.4269+1G>C, Unspecified zygosity (Direct author submission)" - meaning: rrid:CVCL_YY00 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7ae798-a355-4b78-b1c3-6c82e3f917a7" - "Schwann cell NF1 -/- (iPN97.4 #24)": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- (iPN97.4 #24)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=234515dd-7c28-4172-83c7-59dddfa22acb" - "Schwann cell NF1 -/- with R681X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R681X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=faf29a50-3168-4ccd-a484-f2a78a026af3" - "Schwann cell NF1 -/- with R816X mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R816X mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a3e5460-3d5b-45f9-995d-25bd49c06f34" - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA": - description: "[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with WT tagged mNf1 cDNA" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3beebac1-95b0-4834-9008-19f7d268fc5b" - "ScienCell Schwann cells": - description: "[From ScienCell:] HSC from ScienCell Research Laboratories are isolated from human spinal nerve. (editorial note: these cells likely come from multiple donors)" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b751b5d4-56e6-42a2-a2dc-289f90c6dd82" - T265: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_S805 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6419dd0d-1937-4ecf-bf01-876632ae0f54" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=203f9103-dd83-4879-8a5c-9d8541ae2267 T351: - description: "Mutation of NF1, p.Gln28Ter (c.82C>T), Homozygous (PubMed=30737244)." + description: Mutation of NF1, p.Gln28Ter (c.82C>T), Homozygous (PubMed=30737244). meaning: rrid:CVCL_M977 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a29e2129-bee7-4d37-b0b6-c933f6e4bf84" - "T3M-10": - description: "1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap)." - meaning: rrid:CVCL_8067 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c2fbf5a-1c45-43f0-87bb-bb97ea9062f0" - T84: - description: "1 alleles of G13D mutation in KRAS gene. Established from a xenograft produced by subcutaneous injection of the tumor cells into BALB/c nude mice. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=20570890, PubMed=24755471, Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_0555 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=281f0309-ec7d-443a-850f-9327e36c9b9f" - "TM-31": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a29e2129-bee7-4d37-b0b6-c933f6e4bf84 + TM-31: meaning: rrid:CVCL_6735 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb9f27dd-53d0-44c2-a1e9-21a7bbd08fb1" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb9f27dd-53d0-44c2-a1e9-21a7bbd08fb1 TR14: meaning: rrid:CVCL_B474 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8ec4106-295f-4fa3-b744-40b6f9b68d38" - "U-87MG ATCC IDH1 p.R132H": - description: "Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8ec4106-295f-4fa3-b744-40b6f9b68d38 + U-87MG ATCC IDH1 p.R132H: + description: Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), + Heterozygous (from parent cell line). meaning: rrid:CVCL_UE09 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2eb64d9c-3481-455d-b2e4-b9d297ed6366" - "U-87MG ATCC IDH1 p.R132H-Luc2": - description: "Stably expresses firefly luciferase under the control of the human EF-1 alpha promoter. Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)." + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2eb64d9c-3481-455d-b2e4-b9d297ed6366 + U-87MG ATCC IDH1 p.R132H-Luc2: + description: Stably expresses firefly luciferase under the control of the + human EF-1 alpha promoter. Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) + (3737_3740delTGTT), Heterozygous (from parent cell line). meaning: rrid:CVCL_UR35 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64615ea4-6879-49ff-8f10-18c6710cb33c" - "U87-NF1-419": - description: "Generated U87-NF1-419 to evaluate the role of circNF1-419 on cell cycle, apoptosis, proliferation, tumor growth and metabolic regulation" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8eee8013-cc31-43a4-903e-a5db2201e5f0" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64615ea4-6879-49ff-8f10-18c6710cb33c UCD65: - description: "Established from a patient-derived xenograft. ER/PR-positive and ERBB2-negative. Mutation of NF1, p.Leu792fs*2 (c.2372dupT), Unspecified zygosity (PubMed=32576280)." + description: Established from a patient-derived xenograft. ER/PR-positive + and ERBB2-negative. Mutation of NF1, p.Leu792fs*2 (c.2372dupT), Unspecified + zygosity (PubMed=32576280). meaning: rrid:CVCL_ZV44 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=07d262bf-6db9-4825-a25b-b58322b02436" - "UHG-NP": + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=07d262bf-6db9-4825-a25b-b58322b02436 + UHG-NP: meaning: rrid:CVCL_A436 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91cec0db-b483-4674-9636-e2fc4a91bf61" - "WT ES": - description: "[From GFF:] WT ES" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1097f821-56c3-4e51-bcd3-f84aef506e3a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91cec0db-b483-4674-9636-e2fc4a91bf61 WW165: meaning: rrid:CVCL_G321 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ef44c14-d0a5-4933-b433-88da4ec1e30c" - WZJ: - description: "From a surgically excised pNF specimen of a 12-year-old boy with NF1" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb814003-cd22-430d-a3b7-e387ef8eac76" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ef44c14-d0a5-4933-b433-88da4ec1e30c XF: meaning: rrid:CVCL_6E64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2a2dca4-ebcc-4c8e-94c8-c867beaca9ab" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2a2dca4-ebcc-4c8e-94c8-c867beaca9ab XL110: meaning: rrid:CVCL_T702 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0ee4d8e-2435-4e4a-bcc7-051d93fe686a" - YAPC: - description: "1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap)." - meaning: rrid:CVCL_1794 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f51cbf29-987e-4950-9b46-1a607d5413a1" - "YST-1": - description: "Schwannoma cell line, potentially mischaracterized in some cases as a sporadic MPNST cell line." - meaning: rrid:CVCL_5192 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=617cb183-3377-4473-8ad8-2f6472bce1fa" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0ee4d8e-2435-4e4a-bcc7-051d93fe686a YUAME: - description: "Mutation of HRAS, p.Gly13Arg (c.37G>C), Unspecified zygosity (PubMed=26214590)." + description: Mutation of HRAS, p.Gly13Arg (c.37G>C), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_EI13 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df7e5a09-048e-4281-9fbb-52d3ce6cfa15" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df7e5a09-048e-4281-9fbb-52d3ce6cfa15 YUAVEY: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K001 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f87dbfd5-c5ea-4a76-b226-f7282caf042f" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f87dbfd5-c5ea-4a76-b226-f7282caf042f YUBEL: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J515 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5c24057-9be9-433d-bba7-c49ca49cdca6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5c24057-9be9-433d-bba7-c49ca49cdca6 YUBUNE: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J516 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a900c25-09ab-4a7b-b09c-04f7b72b3830" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a900c25-09ab-4a7b-b09c-04f7b72b3830 YUCAL: meaning: rrid:CVCL_J532 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1b65d6a-eb4a-4b19-8952-ce42b28b88ad" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1b65d6a-eb4a-4b19-8952-ce42b28b88ad YUCAS: - description: "Mutation of NF1, p.Ile679Aspfs*21 (c.2033dupC), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Ile679Aspfs*21 (c.2033dupC), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J065 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d21f9de9-7ceb-434d-b940-f2c9781fade9" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d21f9de9-7ceb-434d-b940-f2c9781fade9 YUCHER: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J517 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f00fc26-31a0-464f-94a5-63e49d2deb0d" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f00fc26-31a0-464f-94a5-63e49d2deb0d YUCHIME: - description: "Mutation of NF1, p.Lys1714Asn, Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Lys1714Asn, Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI14 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64b1f481-af8d-47b8-b72a-8efcc2551ac3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64b1f481-af8d-47b8-b72a-8efcc2551ac3 YUCHUFA: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K003 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=730fff1a-f05a-4ef3-9166-31066a998e01" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=730fff1a-f05a-4ef3-9166-31066a998e01 YUCINJ: meaning: rrid:CVCL_K004 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=74c1381d-28e3-483c-8549-2effe3e005c2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=74c1381d-28e3-483c-8549-2effe3e005c2 YUCLAT: - description: "Mutation of NF1, p.Ser2496Phe (c.7487C>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Ser2496Phe (c.7487C>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J518 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a58ef8da-482f-4939-88b0-f48fc791ceb7" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a58ef8da-482f-4939-88b0-f48fc791ceb7 YUCOT: meaning: rrid:CVCL_J066 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=385bf0ee-9d93-4d01-ab72-767e2f07b5c5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=385bf0ee-9d93-4d01-ab72-767e2f07b5c5 YUCYLO: meaning: rrid:CVCL_EI15 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=270fe506-9979-4df5-864a-2f0267e6e0f3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=270fe506-9979-4df5-864a-2f0267e6e0f3 YUDATE: meaning: rrid:CVCL_K006 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe88fad9-bf75-4bd8-8cc3-c05fec76fc5e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe88fad9-bf75-4bd8-8cc3-c05fec76fc5e YUDEDE: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Heterozygous (PubMed=20149136, + PubMed=26214590). meaning: rrid:CVCL_G322 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cef36cc-a45e-4af4-aaff-d929b7f90544" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cef36cc-a45e-4af4-aaff-d929b7f90544 YUDEW: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J519 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe05e40-087b-436a-a222-18e7b4061643" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe05e40-087b-436a-a222-18e7b4061643 YUDOSO: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=20149136, + PubMed=26214590). meaning: rrid:CVCL_G323 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ad85e3f-886e-4e2c-ae51-f07be69d74a3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ad85e3f-886e-4e2c-ae51-f07be69d74a3 YUDUTY: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K007 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72a07165-cd79-4a3d-ae4f-9b79578ea974" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72a07165-cd79-4a3d-ae4f-9b79578ea974 YUFIC: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Heterozygous (PubMed=20149136, + PubMed=26214590). meaning: rrid:CVCL_G324 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abd508df-8730-4ae9-abae-f544616c2ee5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abd508df-8730-4ae9-abae-f544616c2ee5 YUGANK: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K009 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ab474b0-8f19-407d-a85e-3f12dff66075" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ab474b0-8f19-407d-a85e-3f12dff66075 YUGASP: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J520 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c96e7008-ebaf-4a4b-9d11-acc1cd9cf05b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c96e7008-ebaf-4a4b-9d11-acc1cd9cf05b YUGATOR: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_EI17 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ea076a0-c21c-4bbc-b379-13b30c11a5fd" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ea076a0-c21c-4bbc-b379-13b30c11a5fd YUGEN8: meaning: rrid:CVCL_A744 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01611630-bca0-4923-9934-f8c2690b9c7e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01611630-bca0-4923-9934-f8c2690b9c7e YUGOE: - description: "Mutation of NRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gly12Val (c.35G>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J067 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2fcbabd-a6f6-439b-87c0-c1c6dde92128" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2fcbabd-a6f6-439b-87c0-c1c6dde92128 YUHEF: - description: "Mutation of NF1, p.Gln853Ter (c.2557C>T), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Lys2552Thrfs*2, Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Gln853Ter (c.2557C>T), Unspecified zygosity + (PubMed=26214590). Mutation of NF1, p.Lys2552Thrfs*2, Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_G326 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8cc9b6b-d1fc-4e77-8f10-3ca5737bcd5c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8cc9b6b-d1fc-4e77-8f10-3ca5737bcd5c YUKADI: meaning: rrid:CVCL_K011 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8667847-6e03-4db3-ae9a-53bccac0147b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8667847-6e03-4db3-ae9a-53bccac0147b YUKIM: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_G328 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=39e7b045-3bca-47cf-9cd5-e070beda179c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=39e7b045-3bca-47cf-9cd5-e070beda179c YUKOLI: meaning: rrid:CVCL_G329 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e124f7a-e2f4-4e63-965e-f4385c1f7f17" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e124f7a-e2f4-4e63-965e-f4385c1f7f17 YUKSI: meaning: rrid:CVCL_J068 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd13dcdf-bc8b-4d1f-8a53-8409cc3eb7a2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd13dcdf-bc8b-4d1f-8a53-8409cc3eb7a2 YULAPE: - description: "Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K013 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=924186ef-bb8f-46aa-9ef2-bac3a04bdf6b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=924186ef-bb8f-46aa-9ef2-bac3a04bdf6b YULAXER: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K014 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=97c08096-3364-4d31-881c-c9d40e19daa5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=97c08096-3364-4d31-881c-c9d40e19daa5 YULOCUS: - description: "Mutation of KRAS, p.Gly12Ile (c.34_35GG>AT) (c.34_35delinsAT), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Gln2239Ter (c.6715C>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of KRAS, p.Gly12Ile (c.34_35GG>AT) (c.34_35delinsAT), + Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Gln2239Ter (c.6715C>T), + Unspecified zygosity (PubMed=26214590). meaning: rrid:CVCL_EI19 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0bea258-655e-4a9b-a213-48aa86ac42d6" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0bea258-655e-4a9b-a213-48aa86ac42d6 YULOMA: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K015 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0c66ec1-78dc-4dec-9c3a-f2684b836cee" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0c66ec1-78dc-4dec-9c3a-f2684b836cee YULONE: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J523 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9e160e6-76ae-4ae8-8c98-2ea114f6d769" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9e160e6-76ae-4ae8-8c98-2ea114f6d769 YULOVY: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Heterozygous (PubMed=20149136, PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Heterozygous (PubMed=20149136, + PubMed=26214590). meaning: rrid:CVCL_G330 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=384a1121-6aa6-4d4b-8aab-e4539e9d2f26" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=384a1121-6aa6-4d4b-8aab-e4539e9d2f26 YUMAC: meaning: rrid:CVCL_A745 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=696fac03-8787-4298-927c-3848d707f1bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=696fac03-8787-4298-927c-3848d707f1bb YUMINE: meaning: rrid:CVCL_K016 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8c85c7-6714-49ab-83a8-8b0d9338bc03" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8c85c7-6714-49ab-83a8-8b0d9338bc03 YUMOBER: - description: "Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_EI20 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc4a3b69-b7ba-4395-883f-88ff0fc099c2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc4a3b69-b7ba-4395-883f-88ff0fc099c2 YUMUT: meaning: rrid:CVCL_G331 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe79218f-2f91-47f6-a285-c265afbc1a00" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe79218f-2f91-47f6-a285-c265afbc1a00 YUNACK: meaning: rrid:CVCL_EI21 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913f5cef-7da3-44f9-8015-458f6993ea08" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913f5cef-7da3-44f9-8015-458f6993ea08 YUNIBO: meaning: rrid:CVCL_J535 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4990cf1-b921-45f1-94f6-1b286efeb1bb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4990cf1-b921-45f1-94f6-1b286efeb1bb YUPAC7: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_EI22 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffbad5d9-74c8-4a48-8476-8a1a254b63eb" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffbad5d9-74c8-4a48-8476-8a1a254b63eb YUPEET: meaning: rrid:CVCL_K018 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98f2d2a8-f264-4949-8d77-6a5e895d3708" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98f2d2a8-f264-4949-8d77-6a5e895d3708 YUPLA: - description: "Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_J069 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47287b25-40be-4a08-bfa7-94da91b45c08" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47287b25-40be-4a08-bfa7-94da91b45c08 YUPOM: meaning: rrid:CVCL_EI23 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f383e78a-772f-466a-a33b-69ca2864093e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f383e78a-772f-466a-a33b-69ca2864093e YURDE: meaning: rrid:CVCL_K019 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0104b0cf-9664-4f95-854b-04f9146af2be" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0104b0cf-9664-4f95-854b-04f9146af2be YURED: - description: "Mutation of NF1, p.Leu972Pro (c.2915T>C), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Leu972Pro (c.2915T>C), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K020 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cfa26941-984f-4a81-8314-f35c4e13e8bd" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cfa26941-984f-4a81-8314-f35c4e13e8bd YURIF: meaning: rrid:CVCL_B485 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fdfb9ef-767c-4f61-aea2-1b9495f89478" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fdfb9ef-767c-4f61-aea2-1b9495f89478 YURKEN: - description: "Mutation of NF1, p.Pro228Ser (c.682C>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Pro228Ser (c.682C>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K021 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5fbbf3e3-b922-4a20-9720-b175c2260d14" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5fbbf3e3-b922-4a20-9720-b175c2260d14 YUROB: - description: "Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590)." + description: Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_B486 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4cef2d2-31aa-4cd8-90a2-25584fc0e1e0" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4cef2d2-31aa-4cd8-90a2-25584fc0e1e0 YUROL: meaning: rrid:CVCL_J070 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f4f972c-992a-4f71-80d7-b3ce3403e0f8" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f4f972c-992a-4f71-80d7-b3ce3403e0f8 YUSARI: meaning: rrid:CVCL_K022 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=baf37457-11ec-4540-8e2b-28e51a6804d7" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=baf37457-11ec-4540-8e2b-28e51a6804d7 YUSIK: meaning: rrid:CVCL_B487 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5631551-e263-4ed3-b2d6-8a31f6913e63" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5631551-e263-4ed3-b2d6-8a31f6913e63 YUSIPU: meaning: rrid:CVCL_EI16 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e50b8062-cdc9-406d-af28-187b4c50995e" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e50b8062-cdc9-406d-af28-187b4c50995e YUSIT1: meaning: rrid:CVCL_A747 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21c31a9f-36c6-4e3e-a5d4-abac01667a79" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21c31a9f-36c6-4e3e-a5d4-abac01667a79 YUSIV: meaning: rrid:CVCL_G332 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db0bd299-eaf1-475d-81f9-15feb63fc6e3" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db0bd299-eaf1-475d-81f9-15feb63fc6e3 YUSTE: meaning: rrid:CVCL_J527 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37657790-e578-4f21-9127-c6972206b407" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37657790-e578-4f21-9127-c6972206b407 YUSUBA: meaning: rrid:CVCL_K023 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5ed8a55-c03f-467a-9381-58e92ade9f74" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5ed8a55-c03f-467a-9381-58e92ade9f74 YUSWI: meaning: rrid:CVCL_K024 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=77b38c3b-775d-4452-8782-13dd5f069146" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=77b38c3b-775d-4452-8782-13dd5f069146 YUTER: - description: "Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity + (PubMed=26214590). meaning: rrid:CVCL_K025 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4034cf5b-c84f-4b22-ae06-d60edc183621" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4034cf5b-c84f-4b22-ae06-d60edc183621 YUTICA: - description: "Mutation of NF1, p.Pro1667Leu (c.5000C>T), Unspecified zygosity (PubMed=26214590). Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590)." + description: Mutation of NF1, p.Pro1667Leu (c.5000C>T), Unspecified zygosity + (PubMed=26214590). Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified + zygosity (PubMed=26214590). meaning: rrid:CVCL_J071 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8ed167e-22b3-4ab1-a98f-65581c1bc8ab" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8ed167e-22b3-4ab1-a98f-65581c1bc8ab YUWAGE: meaning: rrid:CVCL_K026 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=592cf430-f5fd-4a97-936f-56de2bb5bc3b" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=592cf430-f5fd-4a97-936f-56de2bb5bc3b YUWALI: meaning: rrid:CVCL_K027 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb1c24cb-9912-4b7d-89ca-b97399234671" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb1c24cb-9912-4b7d-89ca-b97399234671 YUWHIM: meaning: rrid:CVCL_K028 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf7ded95-9f27-4cac-9753-d89a9b157b94" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf7ded95-9f27-4cac-9753-d89a9b157b94 YUZAZ: meaning: rrid:CVCL_EI18 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84a6d041-7d20-4a92-8def-55e86ee45062" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84a6d041-7d20-4a92-8def-55e86ee45062 YUZEAL: meaning: rrid:CVCL_K029 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=23aa4d92-5bae-4bee-b506-3a8484f58a2a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=23aa4d92-5bae-4bee-b506-3a8484f58a2a YUZEST: meaning: rrid:CVCL_EI24 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2aaf2d-1dc7-4515-9475-ac07ae59152c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2aaf2d-1dc7-4515-9475-ac07ae59152c ZX2021H: - description: "Mutation of NF1, p.Cys2134Tyrfs*8 (c.6401_6402del) (p.L2133fs, c.6398_6399del), Unspecified zygosity (PubMed=35297208)." + description: Mutation of NF1, p.Cys2134Tyrfs*8 (c.6401_6402del) (p.L2133fs, + c.6398_6399del), Unspecified zygosity (PubMed=35297208). meaning: rrid:CVCL_B6ZD - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08c395bc-b13c-42fa-8b99-ba6864c65928" - "c.1149C > A NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ec8883f5-db93-4c66-9970-792b71b653ac" - "c.1185+1G > A NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3978a8ca-aad8-49f5-a513-70b5acd0f92e" - "c.3431-32_dupGT NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=831ba769-4809-4e31-9214-23bfb0377c19" - "c.5425C > T NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5dbc86-c52d-4713-8a03-ddf3ae42695f" - "c.6619C > T NF1-mutant hiPSCs": - description: "NF1 patient-derived hiPSC line" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13be6b59-6b84-4d38-add9-3e87631bddf3" - cNF00.10a: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF00.10a)." - meaning: rrid:CVCL_B9UZ - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad2e271b-55ac-44ae-b39d-f1a6d76e1dc3" - cNF04.9a: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF04.9a)." - meaning: rrid:CVCL_B9VB - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5b9e065-6855-4a11-bceb-681d8e82ae5e" - cNF97.2a: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2a)." - meaning: rrid:CVCL_B9V1 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d390b3f3-fea7-46d2-9bb7-dc72d59b2ccc" - cNF97.2b: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2b)." - meaning: rrid:CVCL_B9V2 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4987f0a-67ec-4f13-96f1-9443aac6e5ac" - cNF98.4c: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4c)." - meaning: rrid:CVCL_B9V5 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df513bb8-697a-4cac-ae6c-5aca6113ac24" - cNF98.4d: - description: "A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4d)." - meaning: rrid:CVCL_B9V6 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=882101e0-1207-4323-a354-6d5a642e6ca3" - "hTERT NF1 ipNF00.6": - description: "Derived from a plexiform neurofibroma." - meaning: rrid:CVCL_UI76 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8f48ce7-438c-4564-a70b-020abc96d5fe" - "hTERT NF1 ipNF03.3": - description: "Derived from a plexiform neurofibroma." - meaning: rrid:CVCL_UI77 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f21cb7db-ee85-48a7-8f41-e4603238bede" - "hTERT NF1 ipNF04.4": - description: "Derived from a plexiform neurofibroma." - meaning: rrid:CVCL_UI78 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fdc5f7a-ef8c-4193-a5c0-04577c3b134d" - "hTERT NF1 ipNF05.5": - description: "Derived from a plexiform neurofibroma growing on a hand." - meaning: rrid:CVCL_UI71 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5502caf5-4cf1-418f-bf50-164cfa316b0f" - "hTERT NF1 ipNF05.5 (Mixed clones)": - description: "Derived from a plexiform neurofibroma growing on a hand." - meaning: rrid:CVCL_UI72 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844b598c-0171-4972-91c3-27aa21b45d52" - "hTERT NF1 ipNF95.11b C": - description: "Derived from a plexiform neurofibroma growing on a brachial plexus." - meaning: rrid:CVCL_UI67 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be2333d6-6716-4d13-947d-41f4198497a4" - "hTERT NF1 ipNF95.11b C/T": - description: "Derived from a plexiform neurofibroma growing on a brachial plexus." - meaning: rrid:CVCL_UI68 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ab60aae5-7860-4d1d-bb02-208e6631c78b" - "hTERT NF1 ipNF95.6": - description: "Derived from a plexiform neurofibroma growing on cranial nerve XII." - meaning: rrid:CVCL_UI70 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b44361f2-9021-4920-901a-b1a1f9143f97" - "hTERT NF1 ipn06.2 A": - description: "Derived from a pleural plexiform neurofibroma." - meaning: rrid:CVCL_UI74 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dedf9d2-614c-4cf9-8d18-aff8aa2dc0eb" - "hTERT NF1 ipnNF09.4": - description: "Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation." - meaning: rrid:CVCL_UI73 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e0602ff-e3e6-438e-9fb7-c7abc1dd4304" - "hTERT NF1 ipnNF95.11c": - description: "Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation." - meaning: rrid:CVCL_UI69 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c4c8b02-f12e-4a17-a408-38ae88dd841d" - "hTERT NF1 sipnNF95.12B": - description: "Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation." - meaning: rrid:CVCL_UI75 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98beda5b-9b28-4119-829a-2a0219d77af7" - "hTERT SC ipn97.4": - description: "Healthy Schwann cells." - meaning: rrid:CVCL_UI66 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13ae2445-21e3-4b75-ae70-317a3d5ee40c" - "hTERT ipn02.3 2λ": - description: "Derived from peripheral sciatic nerve from a donor without neurofibromatosis. No detectable NF1 mutation." - meaning: rrid:CVCL_UI64 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a507bfd-7d2b-4238-b79a-83fe985c2cea" - "hTERT ipn02.8": - description: "Derived from peripheral nerve from a donor without neurofibromatosis. No detectable NF1 mutation." - meaning: rrid:CVCL_UI65 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a8f5be4-aa22-48f2-9a76-9412010ecd45" - i28cNF: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (28NF)." - meaning: rrid:CVCL_B9VA - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e9ec3f3-5622-4f8f-a02c-34d8777c82b6" - "iPSC NF1 +/- BJFF.6 bkgd": - description: "[From GFF:] iPSC NF1 +/- BJFF.6 bkgd" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0c91627-fad6-4d60-bf74-67623374eff8" - "iPSC NF1 WT": - description: "[From GFF:] iPSC NF1 WT BJFF.6 bkgd" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4cf14492-2735-4e31-ab6a-75554b9ad298" - "iPSC Y489C; Exon 13 cryptic splice": - description: "[From GFF:] iPSC Y489C; Exon 13 cryptic splice, PGP1 cells" - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad73cdb2-8add-48ff-b9f2-35a38132db84" - icNF00.10a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF00.10a)." - meaning: rrid:CVCL_B9V0 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ef2fd6f-9ba6-4e30-94fc-d4ffd61de6e6" - icNF04.9a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF04.9a)." - meaning: rrid:CVCL_B9VC - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=75d4b88a-a906-4f08-a9f8-66490328b9f1" - icNF09.5: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF18.1a." - meaning: rrid:CVCL_D3C7 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9638c45-74f3-4d0d-8bac-67631503f437" - icNF18.1a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF09.5." - meaning: rrid:CVCL_D3C8 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=347edbcd-0b43-4717-bdd2-2f6f31736e31" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08c395bc-b13c-42fa-8b99-ba6864c65928 + AsPC-1: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Homozygous (PubMed=8026879, PubMed=11115575, PubMed=11169959, + PubMed=11787853, PubMed=15367885, PubMed=21607521, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0152 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bbfd278-a1aa-4279-b648-94efe9e1f242 + Calu-1: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (PubMed=12068308, PubMed=12794755, DepMap). + meaning: rrid:CVCL_0608 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=055e78dc-b3d2-416b-a7f1-ac4de9d9ec2b + Capan-1: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (PubMed=8026879, PubMed=8426738, PubMed=15367885, + PubMed=21750719, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0237 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efe31e45-2075-4b41-a06f-a1d5935622fa + Capan-2: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=7961102, PubMed=8026879, PubMed=8426738, + PubMed=11169959, PubMed=15367885, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0026 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a32eaaa-e7cf-45a2-ae52-528a09eea541 + CFPAC-1: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=11169959, PubMed=11787853, PubMed=15367885, + Cosmic-CLP). + meaning: rrid:CVCL_1119 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6f287de-eadb-4020-be7a-5b761172fec6 + COLO 668: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1128 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a57bc0e-51ee-4a44-a872-2ed8ab56f4c6 + COR-L23: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1139 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6928d53-c913-4078-8354-4a5de3d5c824 + DAN-G: + description: 2 alleles of G12V mutation in KRAS gene. Established from a xenograft + produced by implantation of cells from the tumor of a patient with cancer + of the pancreas in a nude mouse (CLS). Mutation of KRAS, p.Gly12Val (c.35G>T), + Unspecified zygosity (CLS, Cosmic-CLP). + meaning: rrid:CVCL_0243 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=99359d65-6e01-410d-be59-217aa0bfb9c9 + GP2d: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (DepMap). + meaning: rrid:CVCL_2450 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c62fab0b-8aa2-4732-9ffb-7d80b8b425ab + HCT 116: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp + (c.38G>A), Heterozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, + PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0291 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=077ce9fd-c141-4baa-b8ac-80aa2922a041 + HCT 15: + description: 1 alleles of G13D mutation in KRAS gene + meaning: rrid:CVCL_0292 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dc12b0e-f9e9-4486-a923-720a8a36bb4e + HPAF-II: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=11787853, PubMed=12068308, PubMed=15367885, + Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0313 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd37b60c-e8f7-451a-87e2-20792451c6fe + HuP-T4: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1300 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1e7bf984-5c1f-463e-89e1-b5d9b552aef5 + KP-3: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (PubMed=21607521, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_3005 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a550816-e561-4d4b-a25c-995ea23b8a41 + LCLC-97TM1: + description: 2 alleles of G12V mutation in KRAS gene + meaning: rrid:CVCL_1376 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7fe3fbf-d242-40b6-9d33-c19e8e0057e0 + LoVo: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp + (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, + PubMed=28683746, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0399 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5ce9c8-7f59-43b0-ac57-3a883d75dff3 + LS180: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=20570890, PubMed=24755471, ATCC). + meaning: rrid:CVCL_0397 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54b8989a-e04f-47ac-bc0c-a5871b943228 + LS513: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471). + meaning: rrid:CVCL_1386 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f95c38-f30f-4ce8-8a92-97baecbc53fc + Lu-65: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1392 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6365e6d0-eefd-4778-9e0f-d8c549838ff2 + Lu-99: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (DepMap). + meaning: rrid:CVCL_3015 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31448c47-8e6d-412c-917a-9f92c53ad687 + MIA PaCa-2: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (PubMed=7961102, PubMed=8026879, PubMed=11115575, + PubMed=11169959, PubMed=11787853, PubMed=12068308, PubMed=21607521, Cosmic-CLP, + DepMap). + meaning: rrid:CVCL_0428 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee325d43-d215-4610-aa67-011ea95efaab + NCI-H1373: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (PubMed=1311061, DepMap). + meaning: rrid:CVCL_1465 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a14754e6-1c26-4224-9ef9-a1abfd1538eb + NCI-H1385: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (DepMap). + meaning: rrid:CVCL_1466 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=93469888-1234-4f52-b3a7-175423b817cc + NCI-H1792: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1495 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d28192f0-d180-40e1-b184-de3fed398e72 + NCI-H1944: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp + (c.38G>A), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1508 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e3ae7e3f-d6ae-48d9-8e08-e2625c048642 + NCI-H2030: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1517 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177c35b5-d859-4bf2-870b-9311ef059159 + NCI-H2122: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1531 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=12d08160-d127-463a-9e6e-c62347f9e756 + NCI-H23: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (PubMed=1311061, PubMed=17088437). + meaning: rrid:CVCL_1547 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95e9ea19-3d84-43a5-b003-347ecec6b1fa + NCI-H2444: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1552 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=da179d37-bc2d-4725-8621-f8ec49b917d0 + NCI-H358: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (PubMed=1311061, PubMed=9649128, PubMed=12068308). + meaning: rrid:CVCL_1559 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cca5b217-ce0b-4c2b-814f-54fefb967475 + NCI-H441: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=1311061, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1561 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=665f978b-9fec-4f0b-8921-058a94b84bcd + NCI-H647: + description: 2 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp + (c.38G>A), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1574 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df53b267-e448-4051-a0d8-1db4da3c5c41 + NCI-H727: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1584 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d124e590-59ba-44c6-9c9f-0b0a3c96862c + NCI-H747: + description: 1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp + (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1587 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06004dd0-1122-46cc-b049-8349d9511c64 + Panc 02.03: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=9612602, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1633 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21237832-d6ba-422e-80ec-36a3ae6d7c7a + Panc 03.27: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1635 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2acf94e6-185b-4717-8f04-71ac8b6d62e3 + Panc 04.03: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1636 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177e4c5c-f9dd-4695-a3ca-fb9205aae724 + Panc 08.13: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Homozygous (PubMed=9612602, ATCC). + meaning: rrid:CVCL_1638 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d861eabe-95d4-47d7-bbb9-be13f7db26f6 + Panc 10.05: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1639 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf2cfa90-a8cd-4ae4-ad5d-2ab86eddd313 + PaTu 8902: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1845 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ead740e0-7ced-4d3c-b411-207cd8f7ae74 + PK-1: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap). + meaning: rrid:CVCL_4717 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53f296e1-638f-44af-8a6f-e9dd601586b0 + PK-45H: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Homozygous (DepMap). + meaning: rrid:CVCL_6748 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e18db26-a0c8-4418-8c64-a73d3fa7e8af + PK-59: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap). + meaning: rrid:CVCL_4897 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f1d08c5-73a8-47e5-b113-031c6a55316d + QGP-1: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=21607521, PubMed=29444910, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_3143 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3b46e6a-030c-4f5e-8d86-d0f540d31edb + RCM-1: + description: 2 alleles of G12V mutation in KRAS gene. Mutation, KRAS, p.Gly12Val + (c.35G>T), Homozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1648 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c003a385-2de1-4ee8-a2d3-212bb746dac9 + RERF-LC-Ad2: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (DepMap). + meaning: rrid:CVCL_1652 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6cb07c1-218d-4762-90d9-4de228447635 + SHP-77: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1693 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b177ff32-b33c-4327-8862-e5b23994b502 + SK-CO-1: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0626 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e7d6716-540f-4206-a32e-4b7ca4b4c53e + SK-LU-1: + description: 1 alleles of G12D mutation in KRAS gene. Cell line positive for + alternative lengthening of telomeres (ALT+). Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (PubMed=1855224, PubMed=12068308, PubMed=12794755, + Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0629 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=903d9857-0c45-4817-a8d6-b43490a3fbcb + SNU-407: + description: 1 alleles of G12D mutation in KRAS gene, KRAS codon 12 GGT->GAT. + Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=10362137, Cosmic-CLP). + meaning: rrid:CVCL_5058 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a05a7478-548d-4e6b-b7d0-17891a503e06 + SNU-C2A: + description: 1 alleles of G12D mutation in KRAS gene. Established from a nude + mouse xenograft. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap). + meaning: rrid:CVCL_1709 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c51a1afa-d499-4630-8995-a61c9fd733b1 + SU.86.86: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Hemizygous (PubMed=11115575). + meaning: rrid:CVCL_3881 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=69abfb3f-7d1e-4433-b542-909b794dd72f + SW1463: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (PubMed=12068308, PubMed=28683746, ATCC, Cosmic-CLP, + DepMap). + meaning: rrid:CVCL_1718 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42a7d7eb-f6df-45b8-80fc-242650606a84 + SW1573: + description: 2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Homozygous (PubMed=12068308, ATCC, Cosmic-CLP). + meaning: rrid:CVCL_1720 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b600b899-2a05-44bb-bc3a-3359a45fa2f9 + SW1990: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1723 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d519727-94e9-4f9e-95d3-9227443c03fe + SW403: + description: 2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, + PubMed=28683746, Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0545 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed7ecfd-36d3-4573-8e07-210c6088c3a7 + SW480: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (PubMed=20570890, PubMed=24755471, PubMed=28683746, + DepMap). + meaning: rrid:CVCL_0546 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b79f24b-7362-4687-8c66-03bcb6a26ab3 + SW620: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Homozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, + PubMed=24755471, PubMed=28683746). + meaning: rrid:CVCL_0547 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cf15506-fb63-49a8-b36e-6a28a67b4c6d + SW837: + description: 2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys + (c.34G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, + PubMed=28683746). + meaning: rrid:CVCL_1729 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8a15b9-b7b8-42b7-ae4e-ca3ae1ac0be7 + SW900: + description: 1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (PubMed=12068308, Cosmic-CLP). + meaning: rrid:CVCL_1731 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=880c525a-f1df-49df-afe5-61ad07304c6a + T3M-10: + description: 1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp + (c.35G>A), Heterozygous (DepMap). + meaning: rrid:CVCL_8067 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c2fbf5a-1c45-43f0-87bb-bb97ea9062f0 + T84: + description: 1 alleles of G13D mutation in KRAS gene. Established from a xenograft + produced by subcutaneous injection of the tumor cells into BALB/c nude mice. + Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=20570890, PubMed=24755471, + Cosmic-CLP, DepMap). + meaning: rrid:CVCL_0555 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=281f0309-ec7d-443a-850f-9327e36c9b9f + YAPC: + description: 1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val + (c.35G>T), Heterozygous (Cosmic-CLP, DepMap). + meaning: rrid:CVCL_1794 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f51cbf29-987e-4950-9b46-1a607d5413a1 + 2-004: + description: Patient-derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b44907f-47e9-470f-918e-03e55cc9eff9 + BTSC 232: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4d9d286-d169-41d0-8dc8-45bc92984aaf + BTSC 233: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b664f320-dd73-4aae-82e7-91c42b48744a + BTSC 3021: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f98c4bb5-b168-431a-8642-f769bed673a3 + BTSC 3047: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=852b8fa5-892d-4353-9d6b-4673396ca999 + BTSC 349: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ea69fa4e-4393-4ffe-a5a8-f4df59789813 + BTSC 380: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98790fc2-9cdf-442c-94d2-e6775cfb8ad3 + c.1149C > A NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ec8883f5-db93-4c66-9970-792b71b653ac + c.1185+1G > A NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3978a8ca-aad8-49f5-a513-70b5acd0f92e + c.3431-32_dupGT NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=831ba769-4809-4e31-9214-23bfb0377c19 + c.5425C > T NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5dbc86-c52d-4713-8a03-ddf3ae42695f + c.6619C > T NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13be6b59-6b84-4d38-add9-3e87631bddf3 + HS53T: + description: human NF1-associated MPNST derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86dcdce8-8416-4157-a31e-04c6edd3ca65 + HSC1λ: + description: human immortalized Schwann cell-based model and a human MPNST + cell line, using CRISPR/Cas9 technology + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0193c87-8813-4841-92e7-ee5095bd94fe + JH-2-002: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1bc84ef2-208f-4f0e-8045-6be47fd968de + JH-2-009: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0bc812b4-f2af-40c4-8245-1070ab12f627 + JH-2-031: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4241b7ff-c08e-4c6d-b2c1-9de9ac91f72b + MPNST 724: + description: human MPNST cell line + meaning: rrid:CVCL_AU20 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7db6b49f-7eec-4b47-bbdc-675a8a464735 + N10: + description: N5 and N10 cells lines underwent CRISPR/Cas9 targeting against NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de94c5d9-6feb-402f-a0c6-6ac3389907c6 + NF1-/- hiPSC-SCPs: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc7520bc-3deb-43c2-81e9-b71cbf4daa65 + NF1+/- hiPSC-SCPs: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa3052b-d40a-4f73-b12e-b68c472497bb + NF10.1: + description: NF1-deficient MPNST tumor cell line from an NF1 patient. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2e468b4-b8cf-4473-b5f5-b7f47415d40f + NF11.1: + description: NF1-deficient MPNST tumor cell line from an NF1 patient. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc674458-affb-46a3-8a48-90fe556b44d1 + NF1C-FiPS-SV4F7: + description: NF1(-/-) iPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=00f8dcc6-a2b2-4fc2-a327-e87367bffa21 + NF1‐iN: + description: fibroblasts cell lines from a NF1 patient + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e608c5ee-fd65-4a08-9c89-9bf16f83956f + NMS-PC: + description: human MPNST cell lines + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c7fb76f-0aae-4e0c-9a69-f50f6a5c5ebb + A68: + description: From a surgically excised pNF specimen of a 51-year-old female + with NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=328fd785-453d-4a09-be93-b7da67d9d33e + WZJ: + description: From a surgically excised pNF specimen of a 12-year-old boy with + NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb814003-cd22-430d-a3b7-e387ef8eac76 + S462s: + description: Human immortalized Schwann cell-based model and a human MPNST + cell line, using CRISPR/Cas9 technology + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c655750-7b47-4cd1-bc5d-2bc6246f5e26 + S462sp: + description: MPNST-derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ab6c976-dbd3-4616-9911-23f4981fa5c5 + SOX10+ SLC: + description: Human induced pluripotent stem cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3e07933-db64-48ea-bfa5-ed22a8647770 + U87-NF1-419: + description: Generated U87-NF1-419 to evaluate the role of circNF1-419 on + cell cycle, apoptosis, proliferation, tumor growth and metabolic regulation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8eee8013-cc31-43a4-903e-a5db2201e5f0 icNF93.1a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. meaning: rrid:CVCL_D3C9 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dcf74355-dce9-4eac-bfda-00984a4e7f3c" - icNF97.2a: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2a)." - meaning: rrid:CVCL_B9V3 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a731535e-f7a6-4c6e-b0db-7f0d0979e69f" - icNF97.2b: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2b)." - meaning: rrid:CVCL_B9V4 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb920757-ad44-4705-815e-31b5bd6105f5" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dcf74355-dce9-4eac-bfda-00984a4e7f3c icNF97.5: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. meaning: rrid:CVCL_D3CA - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3003d963-fb4b-44e0-9b4c-97c5df6d6661" - icNF98.4c: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4c)." - meaning: rrid:CVCL_B9V7 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46da7a41-c654-426e-bfb7-361caf4d3c4c" - icNF98.4d: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4d)" - meaning: rrid:CVCL_B9V8 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd74fd9f-6357-40d5-8569-96883628fb1a" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3003d963-fb4b-44e0-9b4c-97c5df6d6661 icNF99.1: - description: "An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. meaning: rrid:CVCL_D3CB - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27004264-d872-493f-8668-ec4d2425cdc2" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27004264-d872-493f-8668-ec4d2425cdc2 + icNF09.5: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. From the same patient as icNF18.1a. + meaning: rrid:CVCL_D3C7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9638c45-74f3-4d0d-8bac-67631503f437 + icNF18.1a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. From the same patient as icNF09.5. + meaning: rrid:CVCL_D3C8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=347edbcd-0b43-4717-bdd2-2f6f31736e31 ipNF08.1.5: - description: "An hTERT/CDK4-immortalized plexiform neurofibroma cell line derived from a primary cell culture." + description: An hTERT/CDK4-immortalized plexiform neurofibroma cell line derived + from a primary cell culture. meaning: rrid:CVCL_D3CC - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878d9455-2383-4427-88b3-de4fb28de131" - sNF02.2: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_K280 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b72d99fd-ee1e-42ec-92b6-9f89e375cce1" - sNF94.3: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_K164 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504647eb-6b60-492a-bb51-3ab025830f51" - sNF96.2: - description: "MPNST tumor cell line from an NF1 patient." - meaning: rrid:CVCL_K281 - source: "https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c9a87975-378b-4930-8fda-e5896c42c86c" + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878d9455-2383-4427-88b3-de4fb28de131 + HS-PSS: + description: A cell line previously identifed as MPNST, though recent 'omic + analysis suggests that it might not be. + meaning: rrid:CVCL_8717 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd49d4e2-575e-4e89-8317-cff02db4882c + HS-Sch-2: + description: A cell line previously identifed as MPNST, though recent 'omic + analysis suggests that it might not be. + meaning: rrid:CVCL_8718 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19bba596-fc3d-479b-9675-afa369b44dee diff --git a/modules/Sample/ModelSystemType.yaml b/modules/Sample/ModelSystemType.yaml new file mode 100644 index 00000000..ad47232c --- /dev/null +++ b/modules/Sample/ModelSystemType.yaml @@ -0,0 +1,16 @@ +enums: + ModelSystemTypeEnum: + description: Categories of model systems used in research + permissible_values: + cell line: + description: Cultured cell line maintained in vitro + meaning: OBI:0001868 + animal model: + description: Non-human animal model organism used to study disease or biological processes + meaning: OBI:0000659 + organoid: + description: Three-dimensional cell culture model that mimics organ structure and function + meaning: CLO:0037106 + patient-derived xenograft: + description: Tumor tissue from a patient transplanted into an immunodeficient animal model + meaning: EFO:0004939 diff --git a/modules/Sample/generated/AnimalModelDaniorerioNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/AnimalModelDaniorerioNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..a2383344 --- /dev/null +++ b/modules/Sample/generated/AnimalModelDaniorerioNeurofibromatosistype1Enum.yaml @@ -0,0 +1,25 @@ +# Auto-generated filtered enum subset +# Type: animal_model +# Count: 8 entries +# Filters: species=Daniorerio, disorder=Neurofibromatosistype1 + +enums: + AnimalModelDaniorerioNeurofibromatosistype1Enum: + description: 'Animal models: Daniorerio + Neurofibromatosistype1 (8 entries)' + permissible_values: + Nf1adelta5 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e7a8732a-73ba-4d05-88a9-8d796d0f1a6b + Nf1b+10 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d5e90cc-e97a-4321-b0a5-82feed840c50 + Nf1a+/-; Nf1b-/-; p53m/m zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9cf037b-1743-4eef-88ff-8a80659323eb + Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3a1e3de-577d-4b4b-9eed-91dc21c1bbde + Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=757bf9d9-cf3c-400e-b470-d65302d22897 + Nf1adelta8 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=89b2f63c-1538-468e-9ca1-7ff948cb354e + Nf1aL1247X zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cbc2b84-509f-44c6-b4f2-b77731ca34ef + Nf1bdelta55 zebrafish: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3853fe16-e6fe-4520-8e53-9845c1679fbf diff --git a/modules/Sample/generated/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..170d87be --- /dev/null +++ b/modules/Sample/generated/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum.yaml @@ -0,0 +1,21 @@ +# Auto-generated filtered enum subset +# Type: animal_model +# Count: 5 entries +# Filters: species=Drosophilamelanogaster, disorder=Neurofibromatosistype1 + +enums: + AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum: + description: 'Animal models: Drosophilamelanogaster + Neurofibromatosistype1 (5 + entries)' + permissible_values: + dNf1 Drosophila: + description: Homozygous dNf1 null mutants + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7b76ccd-e646-4d30-8868-ba39541dd573 + Nf1P1/Nf1E1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=326557dc-c320-4f04-b64a-08edd703ee95 + Nf1-/- Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=500a5c2f-5104-405e-a243-3d85b59d6b08 + Nf1E1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=52351388-ba1f-4cf8-a03a-23b941d4408e + Nf1P1 Drosophila: + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc95a39a-5f41-4d34-9c0c-f312028aa2f3 diff --git a/modules/Sample/generated/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..c371f25a --- /dev/null +++ b/modules/Sample/generated/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum.yaml @@ -0,0 +1,13 @@ +# Auto-generated filtered enum subset +# Type: animal_model +# Count: 1 entries +# Filters: species=Saccharomycescerevisiae, disorder=Neurofibromatosistype1 + +enums: + AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum: + description: 'Animal models: Saccharomycescerevisiae + Neurofibromatosistype1 + (1 entries)' + permissible_values: + delta-ira1 delta-ira2 yeast: + description: delta-ira1 delta-ira2 double-knockout yeast + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b2a7ee1-e462-42b9-80b8-0a64ca60b091 diff --git a/modules/Sample/generated/AnimalModelSusscrofaNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/AnimalModelSusscrofaNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..03d68be6 --- /dev/null +++ b/modules/Sample/generated/AnimalModelSusscrofaNeurofibromatosistype1Enum.yaml @@ -0,0 +1,19 @@ +# Auto-generated filtered enum subset +# Type: animal_model +# Count: 3 entries +# Filters: species=Susscrofa, disorder=Neurofibromatosistype1 + +enums: + AnimalModelSusscrofaNeurofibromatosistype1Enum: + description: 'Animal models: Susscrofa + Neurofibromatosistype1 (3 entries)' + permissible_values: + Nf1pArg1947mp1: + description: '[From GFF:] Minipig model containing a recurrent nonsense mutation + p.Arg1947*(R1947*) and HindIII RFLP site resulting in frame shift mutation' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=209c16d7-c1fa-414f-8f08-458eaefc2259 + Nf1 heterozygous mutant minipig: + description: heterozygous mutations in NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02aba952-5860-4bd9-bfb2-ff796b22bf48 + Nf1+/ex42del pig: + description: heterozygotic mutation in NF1 (exon 42 deletion) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57625a6e-c039-418e-8e22-db464f8aa827 diff --git a/modules/Sample/generated/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..4305133b --- /dev/null +++ b/modules/Sample/generated/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,27 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 4 entries +# Filters: species=Canislupusfamiliaris, category=Cancer cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Canislupusfamiliaris + Cancer cell line + Noknowngeneticdisorder + (4 entries)' + permissible_values: + CML-6M: + description: Pigmented. Mutation of NF1, p.Pro1599fs (c.4795delCinsTT), Heterozygous + (PubMed=31175136). + meaning: rrid:CVCL_0D24 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=acd954de-1f36-41ad-8ce0-ac738aa840ba + MH/Nike: + description: Mutation of NF1, p.Ala2176fs (c.6525delG), Homozygous (PubMed=31175136). + meaning: rrid:CVCL_DN29 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cb659ee-8d25-4016-a2a5-4c230bfc933e + OSW: + description: Mutation of NF1, p.Asn58fs (c.167delA), Homozygous (PubMed=31175136). + meaning: rrid:CVCL_0B19 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a62af66-384d-419b-b8ac-f4d381b85942 + STSA-1: + description: Mutation of NF1, p.Met877fs (c.2626dupT), Heterozygous (PubMed=31175136). + meaning: rrid:CVCL_D274 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=203f9103-dd83-4879-8a5c-9d8541ae2267 diff --git a/modules/Sample/generated/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..3732d8a2 --- /dev/null +++ b/modules/Sample/generated/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,14 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 1 entries +# Filters: species=Cricetulusgriseus, category=Hybrid cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Cricetulusgriseus + Hybrid cell line + Noknowngeneticdisorder + (1 entries)' + permissible_values: + GM10501: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R95 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb diff --git a/modules/Sample/generated/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..4e588cb0 --- /dev/null +++ b/modules/Sample/generated/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,13 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 1 entries +# Filters: species=Escherichiacoli, category=Undefined cell line type, disorder=Noknowngeneticdisorder + +enums: + CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum: + description: 'Cell lines: Escherichiacoli + Undefined cell line type + Noknowngeneticdisorder + (1 entries)' + permissible_values: + Dh5 alpha: + description: '[From GFF:] Dh5 alpha' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=68977077-e0a3-40df-92ab-d62285edd23c diff --git a/modules/Sample/generated/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..9aa21845 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum.yaml @@ -0,0 +1,200 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 54 entries +# Filters: species=Homosapiens, category=Cancer cell line, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Cancer cell line + Neurofibromatosistype1 + (54 entries)' + permissible_values: + 90-8: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_1B47 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f404e70-2acf-4877-bcd5-6da81d9fa41e + NCC-MPNST3-X2-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU15 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b604846-d41c-4969-a79a-9660c04e585c + ST88-14: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_8916 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=202c110b-a5f1-49ab-acdc-e6e33a1c29bb + HeLa SilenciX NF1: + description: HeLa cervical cancer cells with stable (EBV-based siRNA) knockdown + of the NF1 gene. + meaning: rrid:CVCL_KT82 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2549e536-b033-43e4-acf6-501499b6e498 + sNF94.3: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K164 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504647eb-6b60-492a-bb51-3ab025830f51 + T265: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_S805 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6419dd0d-1937-4ecf-bf01-876632ae0f54 + Nf1-/- Epithelial lung cells: + description: '[From GFF:] Nf1-/- Epithelial lung cells, derived from HBE135-E6E7 + epithelial lung cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=779714c8-f522-4355-a502-d5d2e6e09afa + NCC-MPNST3-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU14 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7fe31236-bc93-449b-b559-9394999be926 + NCC-MPNST5-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU17 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=827f08a1-3d0f-4fd8-98e4-fb5c40a9c742 + NCC-MPNST2-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU13 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f646e44-5263-4f80-bb94-b297a875c52a + S462: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_1Y70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2fb9f7e-ea11-404f-8c0c-c9dc36367f2d + sNF02.2: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K280 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b72d99fd-ee1e-42ec-92b6-9f89e375cce1 + S520: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_AX35 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0a60dec-8ead-43c5-abc2-b06b89dd20cd + sNF96.2: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_K281 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c9a87975-378b-4930-8fda-e5896c42c86c + S462.TY: + description: MPNST tumor cell line from an NF1 patient, created by passaging + S462 cell line in mice as xenografts. + meaning: rrid:CVCL_JK02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6a101aa-9ca8-4191-9b43-eddf327ea48b + NCC-MPNST4-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU16 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f17b839e-acd9-4dbc-a5bb-7d72ed0d0bd8 + NCC-MPNST1-C1: + description: MPNST tumor cell line from an NF1 patient. + meaning: rrid:CVCL_YU12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc3ae45e-9a5b-4fa5-8430-f53479f07f5a + GM01858: + description: Fibroblast from Neurofibroma from an NF1 patient + meaning: rrid:CVCL_9Z58 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4e97f99-a857-4f2d-80f1-62de8a12d037 + GM23312: + description: Tumor-derived cell line from chest an NF1 patient + meaning: rrid:CVCL_CW86 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b104c61a-5a55-4811-97fc-7ce0683b2a14 + '1507.2': + meaning: rrid:CVCL_1Y71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4304050f-f24a-45b9-9025-8e3e88d0b377 + FMS-1: + meaning: rrid:CVCL_IS33 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b14a6ae1-829c-4ae3-9149-9fcf6cc6c57d + FU-SFT8710: + meaning: rrid:CVCL_ZE77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b96c1fa0-5284-424a-b29e-338db3c8b292 + MPNST-14: + meaning: rrid:CVCL_AU21 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=81ae2a05-5102-473f-88fa-9d9bbe8fd35e + MPNST-642: + meaning: rrid:CVCL_AU19 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=818f4c93-dbd3-41f7-b557-f264f7949c6e + MPNST-90: + meaning: rrid:CVCL_J355 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd3db98f-0ec9-40df-bc06-5e314c0fc671 + MPNST-91: + meaning: rrid:CVCL_J356 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fd09582-99a8-40d5-a16b-b250a6975e44 + MPNST-92: + meaning: rrid:CVCL_J357 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa12d6e9-6547-43ad-a666-c17c7c1a9cb3 + NFS-1: + meaning: rrid:CVCL_1Y69 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e6866e8-c67d-4650-a0a3-a10a5a8bdb49 + NMS-2: + description: human MPNST cell lines + meaning: rrid:CVCL_4662 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=83512f26-8cc3-48db-8f66-1b490a943eb1 + NMS-2PC: + meaning: rrid:CVCL_L810 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50b33e18-9c4a-470c-b982-7f612be9a79b + ST88-3: + meaning: rrid:CVCL_IU70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b368f84e-f38b-4ff0-9458-fe5d8b91122d + TM-31: + meaning: rrid:CVCL_6735 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb9f27dd-53d0-44c2-a1e9-21a7bbd08fb1 + 2-004: + description: Patient-derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b44907f-47e9-470f-918e-03e55cc9eff9 + BTSC 232: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4d9d286-d169-41d0-8dc8-45bc92984aaf + BTSC 233: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b664f320-dd73-4aae-82e7-91c42b48744a + BTSC 3021: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f98c4bb5-b168-431a-8642-f769bed673a3 + BTSC 3047: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=852b8fa5-892d-4353-9d6b-4673396ca999 + BTSC 349: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ea69fa4e-4393-4ffe-a5a8-f4df59789813 + BTSC 380: + description: Human patient-derived brain tumor stem cell lines (BTSCs) + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98790fc2-9cdf-442c-94d2-e6775cfb8ad3 + HSC1λ: + description: human immortalized Schwann cell-based model and a human MPNST + cell line, using CRISPR/Cas9 technology + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0193c87-8813-4841-92e7-ee5095bd94fe + JH-2-002: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1bc84ef2-208f-4f0e-8045-6be47fd968de + JH-2-009: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0bc812b4-f2af-40c4-8245-1070ab12f627 + JH-2-031: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4241b7ff-c08e-4c6d-b2c1-9de9ac91f72b + MPNST 724: + description: human MPNST cell line + meaning: rrid:CVCL_AU20 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7db6b49f-7eec-4b47-bbdc-675a8a464735 + NF1-/- hiPSC-SCPs: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc7520bc-3deb-43c2-81e9-b71cbf4daa65 + NF1+/- hiPSC-SCPs: + description: Collected during surgical resection from patients with NF1-MPNST + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa3052b-d40a-4f73-b12e-b68c472497bb + NF10.1: + description: NF1-deficient MPNST tumor cell line from an NF1 patient. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2e468b4-b8cf-4473-b5f5-b7f47415d40f + NF11.1: + description: NF1-deficient MPNST tumor cell line from an NF1 patient. + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc674458-affb-46a3-8a48-90fe556b44d1 + NMS-PC: + description: human MPNST cell lines + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c7fb76f-0aae-4e0c-9a69-f50f6a5c5ebb + A68: + description: From a surgically excised pNF specimen of a 51-year-old female + with NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=328fd785-453d-4a09-be93-b7da67d9d33e + WZJ: + description: From a surgically excised pNF specimen of a 12-year-old boy with + NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb814003-cd22-430d-a3b7-e387ef8eac76 + S462s: + description: Human immortalized Schwann cell-based model and a human MPNST + cell line, using CRISPR/Cas9 technology + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c655750-7b47-4cd1-bc5d-2bc6246f5e26 + S462sp: + description: MPNST-derived cell line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ab6c976-dbd3-4616-9911-23f4981fa5c5 + U87-NF1-419: + description: Generated U87-NF1-419 to evaluate the role of circNF1-419 on + cell cycle, apoptosis, proliferation, tumor growth and metabolic regulation + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8eee8013-cc31-43a4-903e-a5db2201e5f0 diff --git a/modules/Sample/generated/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..e9ce7773 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum.yaml @@ -0,0 +1,104 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 18 entries +# Filters: species=Homosapiens, category=Embryonic stem cell, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Embryonic stem cell + Neurofibromatosistype1 + (18 entries)' + permissible_values: + SZ-NF4: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_YL59 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09c988ab-765a-44ca-b2d7-1957b729208e + KCL025: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_A258 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=18ba4c2e-e8d5-4032-a6ab-d0fca3f0f984 + SZ-NF1: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_YL57 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=33cdb482-618e-4489-87d9-3139cc7c6a49 + SZ-NF2: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_YL58 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc2045df-5ebf-4491-b5b1-88d65e59b228 + Lis42_NF1_1N: + description: Human embryonic stem cell line derived from an embryo with neurofibromatosis + type 1. + meaning: rrid:CVCL_Y368 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd38ffda-2db1-47f0-af6f-8de572e06037 + Lis47_NF1_2N: + description: Human embryonic stem cell line derived from an embryo with neurofibromatosis + type 1. + meaning: rrid:CVCL_Y373 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0ca95f1-a3d9-4641-b47d-84346d9ec04a + KCL024: + description: Human embryonic stem cell line derived from an embryo with an + NF1 mutation. + meaning: rrid:CVCL_A257 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5fdcfb8-24e7-46fa-9f48-bcbae8a90b7a + RG-137: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B564 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b9d9f06-2918-490e-a783-1655c757d922 + RG-138: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B565 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6e0a7ed-94f6-42e1-9700-6cafcb00f426 + RG-139: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B566 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1dc0e42-68f8-4650-89ac-37a6acdeb10e + RG-140: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B567 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2fe9632c-b6db-443f-a512-4b2523a470e0 + RG-141: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, + c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: rrid:CVCL_B568 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aba67450-594d-422b-a7fe-6c69a882b859 + RG-235: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA.' + meaning: rrid:CVCL_B653 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=978d317f-f1d6-4039-a2f5-f0787adf589a + RG-315: + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, + Chicago, USA., Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, + c.5839C>T); Heterozygous (ISCR).' + meaning: rrid:CVCL_B721 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0360411b-59dd-457a-ab6f-38a9182c425e + STR-I-437-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y599 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01040031-60ba-4da5-96b0-d4a0a2f9131b + STR-I-441-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y600 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1372bf73-291f-48f9-9207-81120a299675 + STR-I-443-NF1: + description: 'From: INSERM, France.' + meaning: rrid:CVCL_Y601 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5352596f-7192-473c-85b3-2aeb0fbf8e48 + SZ-NF6: + description: 'From: Shaare Zedek Medical Center, The Hebrew University, Jerusalem, + Israel., Mutation of NF1, c.4269+1G>C, Unspecified zygosity (Direct author + submission)' + meaning: rrid:CVCL_YY00 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7ae798-a355-4b78-b1c3-6c82e3f917a7 diff --git a/modules/Sample/generated/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..13b331f8 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum.yaml @@ -0,0 +1,82 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 16 entries +# Filters: species=Homosapiens, category=Finite cell line, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Finite cell line + Neurofibromatosistype1 + (16 entries)' + permissible_values: + NF1: + description: Cell line from an NF1 patient; unclear if derived from tumor + or non-tumor tissue. + meaning: rrid:CVCL_JG80 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a8a362e-e3be-4bc3-be7e-d0a0865b9c31 + 28cNF: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (i28NF). + meaning: rrid:CVCL_B9V9 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a466cdc-5eaa-45a5-87b1-ba9cac6d7d21 + cNF98.4d: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF98.4d). + meaning: rrid:CVCL_B9V6 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=882101e0-1207-4323-a354-6d5a642e6ca3 + cNF00.10a: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF00.10a). + meaning: rrid:CVCL_B9UZ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad2e271b-55ac-44ae-b39d-f1a6d76e1dc3 + cNF97.2b: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF97.2b). + meaning: rrid:CVCL_B9V2 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4987f0a-67ec-4f13-96f1-9443aac6e5ac + cNF04.9a: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF04.9a). + meaning: rrid:CVCL_B9VB + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5b9e065-6855-4a11-bceb-681d8e82ae5e + cNF97.2a: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF97.2a). + meaning: rrid:CVCL_B9V1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d390b3f3-fea7-46d2-9bb7-dc72d59b2ccc + cNF98.4c: + description: A primary cutaneous neurofibroma cell line; not broadly available. + See the immortalized version (icNF98.4c). + meaning: rrid:CVCL_B9V5 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df513bb8-697a-4cac-ae6c-5aca6113ac24 + GM00622: + description: Fibroblast from an NF1 patient + meaning: rrid:CVCL_5M64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1edebf4d-8ea4-4071-90bf-7e934c7ab029 + GM01633: + description: Fibroblast from an NF1 patient + meaning: rrid:CVCL_9Z54 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa663228-7ffe-4604-9cda-95b29b8d7386 + GM01639: + description: Fibroblast from an NF1 patient + meaning: rrid:CVCL_5M68 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2677690-2137-408e-b250-784a0cd235f4 + GM01859: + description: Fibroblast from Neurofibroma from an NF1 patient + meaning: rrid:CVCL_9Z59 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3899a07c-6fb8-4fc2-997f-c2301d6082f7 + GM21675: + description: Fibroblast derived from skin from an NF1 patient + meaning: rrid:CVCL_HL12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf150ecf-4971-4500-ae94-5d25e4895d63 + GM22279: + description: Fibroblast from an NF1 patient + meaning: rrid:CVCL_BA11 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ba4aabde-a800-4cca-b4de-1f4f4c8c06cc + GM22607: + description: Fibroblast derived from skin from an NF1 patient + meaning: rrid:CVCL_BU81 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc4c4f3b-34c3-447f-9422-0262d7b43ae5 + GM22609: + description: Fibroblast derived from skin from an NF1 patient + meaning: rrid:CVCL_BU83 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f18f5f6b-09c7-4367-89d5-c065137888db diff --git a/modules/Sample/generated/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..2c67163b --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,15 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 1 entries +# Filters: species=Homosapiens, category=Finite cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Homosapiens + Finite cell line + Noknowngeneticdisorder + (1 entries)' + permissible_values: + ScienCell Schwann cells: + description: '[From ScienCell:] HSC from ScienCell Research Laboratories are + isolated from human spinal nerve. (editorial note: these cells likely come + from multiple donors)' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b751b5d4-56e6-42a2-a2dc-289f90c6dd82 diff --git a/modules/Sample/generated/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..8b17309b --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,30 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 5 entries +# Filters: species=Homosapiens, category=Hybrid cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Homosapiens + Hybrid cell line + Noknowngeneticdisorder + (5 entries)' + permissible_values: + GM10501: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R95 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb + GM10502: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R96 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965 + GM10657: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R97 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7 + GM10659: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R98 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3 + GM12517: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1S66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81 diff --git a/modules/Sample/generated/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..77c32607 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum.yaml @@ -0,0 +1,136 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 32 entries +# Filters: species=Homosapiens, category=Induced pluripotent stem cell, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Induced pluripotent stem cell + Neurofibromatosistype1 + (32 entries)' + permissible_values: + 3PNF_SiPSsv_MM_11: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN12 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cc872fc-6a95-4722-a598-bf60bb124b82 + 3PNF_FiPSsv_PM_2: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN11 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7deb7765-38aa-4d8a-a3cb-bd4aefeb3a86 + 5PNF_TDiPSsv_PM_6: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN14 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ebe9be8-88df-4598-bd25-510de550ca5e + 7PNF_SiPSrv_PM_12: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN16 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95997768-950e-4c8d-93bb-e6ed370e503f + 5PNF_TDiPSsv_MM_4: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN13 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db6b3d0d-ee80-49ab-bb51-5672448e580b + 6PNF_SiPSrv_PM_2: + description: Cutaneous neurofibroma-derived iPSC banked in the Barcelona node + of the Spanish National Cell Bank. + meaning: rrid:CVCL_UN15 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4deb9a8-7929-44f2-974d-375771b8c681 + HPS1312: + meaning: rrid:CVCL_UN64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e85ecf49-5767-41bd-86f8-2c24c3565a14 + HPS1313: + meaning: rrid:CVCL_A3UD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f0bb3a66-ad46-4458-bb2a-eb01d5860aaf + HPS1314: + meaning: rrid:CVCL_A3UE + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2b29409-3d0c-4ff6-a1d4-eb1ea8e856bb + HPS1315: + meaning: rrid:CVCL_A3UF + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2c7033c-1cc1-437c-8dd5-699ce1c52c31 + HPS1316: + meaning: rrid:CVCL_A3UG + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=88c655aa-2117-4a84-a15f-ddfa3abcf0e9 + HPS1317: + meaning: rrid:CVCL_A3UH + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d1529d1-682a-493f-accf-c498a8a06f29 + HPS2250: + meaning: rrid:CVCL_UP04 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85718709-ca03-493c-be51-f63650440435 + HPS2251: + meaning: rrid:CVCL_A3RL + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d29aaa05-2dae-4f67-b8b1-742d182a6b83 + HPS2252: + meaning: rrid:CVCL_A3RM + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d4806ba-76ec-452c-881b-7a7b48828790 + HPS2253: + meaning: rrid:CVCL_A3RN + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b5a2e06e-fd9e-4586-9ab9-4a950815d4c1 + HPS2254: + meaning: rrid:CVCL_A3RP + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a687df-afc8-493f-8f5a-a40eceb32946 + HPS2255: + meaning: rrid:CVCL_A3RQ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25a6d925-3be3-42d1-8373-e7f8c5fe85aa + MCRIi020-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d941428a-ebcb-4acf-90ae-107d7cfc52d1 + MCRIi021-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1ME + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a676545-f9b5-4fdb-bf0f-3b68dfdb58b8 + MCRIi022-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MF + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb564630-535a-4d14-8a07-f2b4e64f4926 + MCRIi023-A: + description: 'Human induced pluripotent stem cell (iPSC) line from peripheral + blood mononuclear cells (PBMC) from individual with neurofibromatosis type + (NF1). From: Murdoch Children''s Research Institute, Melbourne, Australia.' + meaning: rrid:CVCL_A1MG + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8295296a-e1d7-4c9f-beaa-2ac02d09c149 + SMBCi003-A: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous + (PubMed=32554297). + meaning: rrid:CVCL_YC55 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25e3f6d6-c625-43fc-a1ed-c267bba685f1 + SMBCi003-B: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous + (PubMed=32554297). + meaning: rrid:CVCL_YC56 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0361ea84-13bb-4f90-8f24-bbd01a81801e + SMBCi003-C: + description: Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous + (from autologous cell lines SMBCi003-A and SMBCi003-B). + meaning: rrid:CVCL_YC57 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08a0f6ee-700b-4df3-94cd-cc414214ca99 + c.1149C > A NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ec8883f5-db93-4c66-9970-792b71b653ac + c.1185+1G > A NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3978a8ca-aad8-49f5-a513-70b5acd0f92e + c.3431-32_dupGT NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=831ba769-4809-4e31-9214-23bfb0377c19 + c.5425C > T NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5dbc86-c52d-4713-8a03-ddf3ae42695f + c.6619C > T NF1-mutant hiPSCs: + description: NF1 patient-derived hiPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13be6b59-6b84-4d38-add9-3e87631bddf3 + NF1C-FiPS-SV4F7: + description: NF1(-/-) iPSC line + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=00f8dcc6-a2b2-4fc2-a327-e87367bffa21 + SOX10+ SLC: + description: Human induced pluripotent stem cells + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3e07933-db64-48ea-bfa5-ed22a8647770 diff --git a/modules/Sample/generated/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..6d8fb99a --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,37 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 7 entries +# Filters: species=Homosapiens, category=Induced pluripotent stem cell, disorder=Noknowngeneticdisorder + +enums: + CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum: + description: 'Cell lines: Homosapiens + Induced pluripotent stem cell + Noknowngeneticdisorder + (7 entries)' + permissible_values: + GM23338: + description: '[From GFF:] iPSC NF1 WT, PGP1 cells' + meaning: rrid:CVCL_F182 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c4e4b03-5975-4708-a25c-f6c45cbe3abf + iPSC NF1 WT: + description: '[From GFF:] iPSC NF1 WT BJFF.6 bkgd' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4cf14492-2735-4e31-ab6a-75554b9ad298 + BJFF.6: + description: iPSCs created with foreskin fibroblasts. + meaning: rrid:CVCL_VU02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8a213a9d-392b-4746-8f59-c12f753d9217 + iPSC NF1 +/- BJFF.6 bkgd: + description: '[From GFF:] iPSC NF1 +/- BJFF.6 bkgd' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0c91627-fad6-4d60-bf74-67623374eff8 + iPSC Y489C; Exon 13 cryptic splice: + description: '[From GFF:] iPSC Y489C; Exon 13 cryptic splice, PGP1 cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad73cdb2-8add-48ff-b9f2-35a38132db84 + PEO4-iPSC-OSKM-03: + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp + (c.478A>T), Homozygous (from parent cell line). + meaning: rrid:CVCL_B7JI + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7126593e-4b96-40a5-9ff4-d41b81fbba4c + PEO4-iPSC-OSKM-05: + description: Mutation, NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp + (c.478A>T), Homozygous (from parent cell line). + meaning: rrid:CVCL_B7JJ + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f103987e-5196-440e-a6ba-53d39305c714 diff --git a/modules/Sample/generated/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..6d1c6218 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,19 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 3 entries +# Filters: species=Homosapiens, category=Spontaneously immortalized cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Homosapiens + Spontaneously immortalized cell line + + Noknowngeneticdisorder (3 entries)' + permissible_values: + MCF10A_NF1_1: + meaning: rrid:CVCL_C1A6 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd6b1f88-b716-47d4-9869-84d58b18c2eb + MCF10A_NF1_7A1: + meaning: rrid:CVCL_C1A7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f506b298-5b5e-4ea6-abe3-49b4f69d871b + MCF10A_NF1_7B2: + meaning: rrid:CVCL_C1A8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7e0c9b3-008d-415f-bd1e-8fc33d55e497 diff --git a/modules/Sample/generated/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..adc93d09 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum.yaml @@ -0,0 +1,127 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 25 entries +# Filters: species=Homosapiens, category=Telomerase immortalized cell line, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Telomerase immortalized cell line + Neurofibromatosistype1 + (25 entries)' + permissible_values: + hTERT NF1 ipnNF95.11c: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 + patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI69 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c4c8b02-f12e-4a17-a408-38ae88dd841d + hTERT NF1 ipn06.2 A: + description: Derived from a pleural plexiform neurofibroma. + meaning: rrid:CVCL_UI74 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dedf9d2-614c-4cf9-8d18-aff8aa2dc0eb + icNF98.4c: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF98.4c). + meaning: rrid:CVCL_B9V7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46da7a41-c654-426e-bfb7-361caf4d3c4c + hTERT NF1 ipNF05.5: + description: Derived from a plexiform neurofibroma growing on a hand. + meaning: rrid:CVCL_UI71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5502caf5-4cf1-418f-bf50-164cfa316b0f + icNF04.9a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF04.9a). + meaning: rrid:CVCL_B9VC + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=75d4b88a-a906-4f08-a9f8-66490328b9f1 + icNF00.10a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF00.10a). + meaning: rrid:CVCL_B9V0 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ef2fd6f-9ba6-4e30-94fc-d4ffd61de6e6 + hTERT NF1 ipNF05.5 (Mixed clones): + description: Derived from a plexiform neurofibroma growing on a hand. + meaning: rrid:CVCL_UI72 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844b598c-0171-4972-91c3-27aa21b45d52 + hTERT NF1 ipnNF09.4: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 + patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI73 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e0602ff-e3e6-438e-9fb7-c7abc1dd4304 + i28cNF: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (28NF). + meaning: rrid:CVCL_B9VA + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e9ec3f3-5622-4f8f-a02c-34d8777c82b6 + hTERT NF1 ipNF04.4: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI78 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fdc5f7a-ef8c-4193-a5c0-04577c3b134d + hTERT NF1 sipnNF95.12B: + description: Derived from a peripheral nerve in a neurofibromatosis type 1 + patient. No detectable somatic NF1 mutation. + meaning: rrid:CVCL_UI75 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98beda5b-9b28-4119-829a-2a0219d77af7 + icNF97.2a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF97.2a). + meaning: rrid:CVCL_B9V3 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a731535e-f7a6-4c6e-b0db-7f0d0979e69f + hTERT NF1 ipNF00.6: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI76 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8f48ce7-438c-4564-a70b-020abc96d5fe + hTERT NF1 ipNF95.11b C/T: + description: Derived from a plexiform neurofibroma growing on a brachial plexus. + meaning: rrid:CVCL_UI68 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ab60aae5-7860-4d1d-bb02-208e6631c78b + hTERT NF1 ipNF95.6: + description: Derived from a plexiform neurofibroma growing on cranial nerve + XII. + meaning: rrid:CVCL_UI70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b44361f2-9021-4920-901a-b1a1f9143f97 + icNF98.4d: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF98.4d) + meaning: rrid:CVCL_B9V8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd74fd9f-6357-40d5-8569-96883628fb1a + hTERT NF1 ipNF95.11b C: + description: Derived from a plexiform neurofibroma growing on a brachial plexus. + meaning: rrid:CVCL_UI67 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be2333d6-6716-4d13-947d-41f4198497a4 + icNF97.2b: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture (cNF97.2b). + meaning: rrid:CVCL_B9V4 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb920757-ad44-4705-815e-31b5bd6105f5 + hTERT NF1 ipNF03.3: + description: Derived from a plexiform neurofibroma. + meaning: rrid:CVCL_UI77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f21cb7db-ee85-48a7-8f41-e4603238bede + icNF93.1a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. + meaning: rrid:CVCL_D3C9 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dcf74355-dce9-4eac-bfda-00984a4e7f3c + icNF97.5: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. + meaning: rrid:CVCL_D3CA + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3003d963-fb4b-44e0-9b4c-97c5df6d6661 + icNF99.1: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. + meaning: rrid:CVCL_D3CB + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27004264-d872-493f-8668-ec4d2425cdc2 + icNF09.5: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. From the same patient as icNF18.1a. + meaning: rrid:CVCL_D3C7 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9638c45-74f3-4d0d-8bac-67631503f437 + icNF18.1a: + description: An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived + from a primary cell culture. From the same patient as icNF09.5. + meaning: rrid:CVCL_D3C8 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=347edbcd-0b43-4717-bdd2-2f6f31736e31 + ipNF08.1.5: + description: An hTERT/CDK4-immortalized plexiform neurofibroma cell line derived + from a primary cell culture. + meaning: rrid:CVCL_D3CC + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878d9455-2383-4427-88b3-de4fb28de131 diff --git a/modules/Sample/generated/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..b4f0b031 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,44 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 7 entries +# Filters: species=Homosapiens, category=Telomerase immortalized cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Homosapiens + Telomerase immortalized cell line + Noknowngeneticdisorder + (7 entries)' + permissible_values: + hTERT SC ipn97.4: + description: Healthy Schwann cells. + meaning: rrid:CVCL_UI66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13ae2445-21e3-4b75-ae70-317a3d5ee40c + 'Schwann cell NF1 -/- (iPN97.4 #24)': + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- (iPN97.4 #24)' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=234515dd-7c28-4172-83c7-59dddfa22acb + Schwann cell NF1 -/- with R816X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- with R816X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a3e5460-3d5b-45f9-995d-25bd49c06f34 + hTERT ipn02.3 2λ: + description: Derived from peripheral sciatic nerve from a donor without neurofibromatosis. + No detectable NF1 mutation. + meaning: rrid:CVCL_UI64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a507bfd-7d2b-4238-b79a-83fe985c2cea + hTERT ipn02.8: + description: Derived from peripheral nerve from a donor without neurofibromatosis. + No detectable NF1 mutation. + meaning: rrid:CVCL_UI65 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a8f5be4-aa22-48f2-9a76-9412010ecd45 + Schwann cell NF1 -/- with WT tagged mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- with WT tagged mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3beebac1-95b0-4834-9008-19f7d268fc5b + Schwann cell NF1 -/- with R681X mNf1 cDNA: + description: '[From GFF:] This cell line is in development and not comprehensively + characterized. Please contact the investigator for more information. Schwann + cell NF1 -/- with R681X mNf1 cDNA' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=faf29a50-3168-4ccd-a484-f2a78a026af3 diff --git a/modules/Sample/generated/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..1f288a7c --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum.yaml @@ -0,0 +1,148 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 29 entries +# Filters: species=Homosapiens, category=Transformed cell line, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Transformed cell line + Neurofibromatosistype1 + (29 entries)' + permissible_values: + GM11601: + description: Leukemia cell line derived from B-lymphocytes from an NF1 patient. + meaning: rrid:CVCL_AA01 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2f62c57-a1b8-4867-9c91-04406f261cfa + GM01634: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z57 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9722c74b-e82e-4ac7-b684-4bab1a409a78 + GM01641: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_5M69 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9db66052-f458-4400-ae1b-3f5c075dbd25 + GM01861: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z60 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46cc2e4e-d9bf-4474-b4de-448e25fb0c66 + GM03420: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z61 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ebbfa6b-049f-4e85-af96-be49c3b5b31a + GM03421: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z62 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5570368b-f20e-47ed-9656-0b9d49c53c9f + GM09534: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z63 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4106cadd-2071-437e-8c43-6f5751332128 + GM09535: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bdf2270-d002-41bf-b75d-2a1d890f9967 + GM09539: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f77c8f5-a9a2-4d1a-a34a-79e912718c91 + GM09616: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z67 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c569a3f9-9c0c-48fe-bbb5-7ae5cb6c384a + GM09619: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z69 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bdd8125b-cf6d-45f3-8cea-20af6e21a1da + GM09627: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z74 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96456d2b-062d-42ab-a1ce-ff3df6f7ab5b + GM09628: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z75 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b636771-68eb-4a86-801e-546bcb4f9b25 + GM09633: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z80 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cba1c774-499d-4d01-b3d2-a62f670b03ce + GM09634: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z81 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=327fcda4-f2ef-4cb5-9245-d3256960f17f + GM09635: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z82 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9d1561b3-b430-4a9b-984d-1c77a02f1a23 + GM09637: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z84 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fd4f461-6137-4922-81b1-e9f30d993df1 + GM09690: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z96 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41307a11-4252-4563-bb7d-afe570cf1620 + GM09692: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z98 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c83b346e-57de-41b3-9a28-7e60a2f78483 + GM09693: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_9Z99 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1dbbb94-a4e6-4829-a3db-455480b0a535 + GM21674: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_HL11 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2e3f513-8780-4f7e-985a-4dd4eab7de95 + GM21843: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_BA07 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4280272c-022d-45bd-9c0f-20d96b69aba8 + GM21844: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_BA08 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7c5369fa-2ea8-45a1-93be-d6e22e1ac695 + GM21865: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_BA10 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=38dcffa4-463a-482b-8d6c-5d787ac3a1c4 + GM22606: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_BU80 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=809601e0-75ef-460c-9e95-9c454e06c474 + GM22608: + description: Lymphoblastoid cell line derived from B-lymphocytes from an NF1 + patient + meaning: rrid:CVCL_BU82 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce964197-a694-41fb-8f25-66cd84c86e50 + DD2345: + description: An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line + meaning: rrid:CVCL_9J79 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2e792f78-55b0-4091-9f86-6b78abd920bb + QQ0588: + description: An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line + meaning: rrid:CVCL_8Y66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53c871d3-6f75-49a6-aa73-42d0ead2298b + N10: + description: N5 and N10 cells lines underwent CRISPR/Cas9 targeting against NF1 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de94c5d9-6feb-402f-a0c6-6ac3389907c6 diff --git a/modules/Sample/generated/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..0cb73b7c --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,134 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 31 entries +# Filters: species=Homosapiens, category=Transformed cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Homosapiens + Transformed cell line + Noknowngeneticdisorder + (31 entries)' + permissible_values: + GM11602: + description: Leukemia cell line derived from B-lymphocytes from an NF1 patient. + meaning: rrid:CVCL_AA02 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f354ec1a-0305-4e6c-897a-10e4fba10a28 + GM09536: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z65 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=afcff3ca-6421-4c66-bd87-94ad21493b1d + GM09617: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z68 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f34019e4-be8b-4f75-9f68-a79032c8705b + GM09618: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_N114 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a9d486c-1cd0-4cab-b3d7-cbe17058d457 + GM09620: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z70 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=559404ce-6df0-4109-bdeb-6521d8928f1c + GM09621: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z71 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=026b1ceb-5f1c-4497-825c-ee3cc5d9d2ed + GM09622: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z72 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4cf20b8-9e30-4798-8281-25b83346458d + GM09625: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z73 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0843b842-e9d2-4b23-9a53-aebf01ae31e3 + GM09626: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_N115 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59bac805-44b6-4397-8195-6005fcedcd95 + GM09629: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z76 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86145b27-da2e-4b32-9ddc-e247374fe10e + GM09630: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z77 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be65ffe-18cb-46c4-b910-6e5a3cc5612a + GM09631: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z78 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22ca8958-b953-461d-9301-016f57cd08a5 + GM09632: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z79 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a28aea84-6495-4863-80cc-08066079deef + GM09636: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z83 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b213001-31a3-4c59-bf32-4e5407c01e82 + GM09638: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z85 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f00ae7c4-4eea-49e4-92d1-43382dfd31bb + GM09639: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z86 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd411ce0-865d-47d7-a5c4-84084f5aadb5 + GM09640: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z87 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6a894263-7e2b-46f5-81b1-9aa351590843 + GM09641: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z88 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc42f6e8-494c-49ff-880f-be2352f3a87e + GM09642: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z89 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6d3fc47-cd5d-4b7e-a5b7-7c10cecb2490 + GM09649: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z90 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4996ae57-c5df-4832-8990-cea9133004bc + GM09650: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z91 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b16247aa-fd06-4103-9f5e-50e0e7d06805 + GM09651: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z92 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=432fefde-722b-44f0-8f11-bbc97920b5f6 + GM09652: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z93 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08309e7c-d0a5-457e-91bc-9c5113347ee2 + GM09688: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z94 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09799642-3547-4033-a094-5ba1dd08da60 + GM09689: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z95 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=220c8dae-1759-4834-b952-c9b68469137a + GM09691: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9Z97 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7df4a356-0194-47d4-9a78-291b8083ed18 + GM09694: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_6F53 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6b2e6bfa-e869-4970-a71c-10abd3224ea9 + GM09886: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9T23 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f597b96-5566-45f6-81c6-592c82cb3465 + GM09887: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_9X49 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed96e95-c815-4151-ade9-40510601255f + GM09944: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_AA00 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0abcee2-581c-4c1a-9ef8-93b57dd0f96d + GM21845: + description: Lymphoblastoid cell line derived from B-lymphocytes + meaning: rrid:CVCL_BA09 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3281d1ba-5d0d-4dca-b583-9c610814fb76 diff --git a/modules/Sample/generated/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..c1578c40 --- /dev/null +++ b/modules/Sample/generated/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum.yaml @@ -0,0 +1,16 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 2 entries +# Filters: species=Homosapiens, category=Undefined cell line type, disorder=Neurofibromatosistype1 + +enums: + CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum: + description: 'Cell lines: Homosapiens + Undefined cell line type + Neurofibromatosistype1 + (2 entries)' + permissible_values: + Nf1-/- skin-derived precursor cells: + description: '[From GFF:] Nf1-/- skin-derived precursor cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=15c3bd82-9791-4a53-b6f7-4d23b882a285 + NF1‐iN: + description: fibroblasts cell lines from a NF1 patient + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e608c5ee-fd65-4a08-9c89-9bf16f83956f diff --git a/modules/Sample/generated/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..d39a506c --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,22 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 4 entries +# Filters: species=Musmusculus, category=Cancer cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Musmusculus + Cancer cell line + Noknowngeneticdisorder + (4 entries)' + permissible_values: + 10/9CRC1: + meaning: rrid:CVCL_8478 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25c617df-ff54-4ba5-b293-d9fcc9be39ce + 4/30PRR: + meaning: rrid:CVCL_8480 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0aed5bf6-d5e2-4a6d-ac3b-a51b5e8bbb8b + 862L: + meaning: rrid:CVCL_8477 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6faf7e00-d770-4527-9384-539f6db31977 + 9/3L: + meaning: rrid:CVCL_8479 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c98ce5c-5cf1-4829-943d-5142073583d8 diff --git a/modules/Sample/generated/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..a7aab35b --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum.yaml @@ -0,0 +1,19 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 3 entries +# Filters: species=Musmusculus, category=Embryonic stem cell, disorder=Neurofibromatosistype1 + +enums: + CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum: + description: 'Cell lines: Musmusculus + Embryonic stem cell + Neurofibromatosistype1 + (3 entries)' + permissible_values: + Nf1Arg681*/Arg681* MEFs: + description: '[From GFF:] Nf1Arg681*/Arg681* MEFs' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47f50ef0-8d59-430d-9d05-7df1a4f41c3b + Nf1Arg681*/+ ES: + description: '[From GFF:] Nf1Arg681*/+ ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ff97eee-5c1a-4439-9df6-d1715cbdd189 + Nf1Arg681*/Arg681* ES: + description: '[From GFF:] Nf1Arg681*/Arg681* ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=70c1e3f6-751f-49e4-aa47-e3bea4aeac43 diff --git a/modules/Sample/generated/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..80d54e31 --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,35 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 5 entries +# Filters: species=Musmusculus, category=Embryonic stem cell, disorder=Noknowngeneticdisorder + +enums: + CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum: + description: 'Cell lines: Musmusculus + Embryonic stem cell + Noknowngeneticdisorder + (5 entries)' + permissible_values: + NF1-R68X Embryonic cells: + description: '[From GFF:] NF1-R68X Embryonic cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90748442-be62-44f1-899e-804cd5600823 + KOMP ES cell line Nf1: + description: JM8.F6 derived from C57BL/6N + meaning: rrid:MMRRC_059313-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d596eb56-33b0-4dcc-b7e4-0922a93c4134 + KOMP ES cell line Nf1: + description: JM8.F6 derived from C57BL/6N + meaning: rrid:MMRRC_059314-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e0a4cc28-022b-48ed-acf5-28ee38eb20bd + SIGTR ES cell line AA0320: + description: High throughput gene trapping was performed by inserting a gene + trap vector containing a splice-acceptor sequence upstream of a reporter + gene, β-geo (a fusion of β-galactosidase and neomycin phosphotransferase + II), into an intronic or coding region of genomic DNA. The resulting insertional + mutation creates a fusion transcript containing sequences from exons upstream + of the insertion joined to the β-geo marker, allowing cell lines where the + vector has successfully interrupted a gene to be identified. + meaning: rrid:MMRRC_025689-UCD + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8a75443-a92f-45f7-9290-0669405e2e9c + BayGenomics ES cell line XF344: + description: Nf1 knockout cell + meaning: rrid:CVCL_PR85 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=60633d59-0230-47c3-9d40-08b0ae194b6d diff --git a/modules/Sample/generated/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..d9c08ee8 --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,26 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 4 entries +# Filters: species=Musmusculus, category=Hybrid cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Musmusculus + Hybrid cell line + Noknowngeneticdisorder + (4 entries)' + permissible_values: + GM10502: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R96 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965 + GM10657: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R97 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7 + GM10659: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1R98 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3 + GM12517: + description: Human/rodent somatic cell hybrid + meaning: rrid:CVCL_1S66 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81 diff --git a/modules/Sample/generated/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..b84ab6c7 --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,19 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 3 entries +# Filters: species=Musmusculus, category=Hybridoma, disorder=Noknowngeneticdisorder + +enums: + CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum: + description: 'Cell lines: Musmusculus + Hybridoma + Noknowngeneticdisorder (3 + entries)' + permissible_values: + CPTC-NF1-1: + meaning: rrid:CVCL_C2NU + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65d07476-2469-4679-85b2-e2ca67f3b01b + CPTC-NF1-2: + meaning: rrid:CVCL_C2NV + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f410431d-7571-4302-8870-eb115b71d0ce + CPTC-NF1-3: + meaning: rrid:CVCL_C2NW + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42257ac4-1950-4541-9bee-b9a965e2fa86 diff --git a/modules/Sample/generated/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..b8aeebe8 --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,13 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 1 entries +# Filters: species=Musmusculus, category=Induced pluripotent stem cell, disorder=Noknowngeneticdisorder + +enums: + CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum: + description: 'Cell lines: Musmusculus + Induced pluripotent stem cell + Noknowngeneticdisorder + (1 entries)' + permissible_values: + WT ES: + description: '[From GFF:] WT ES' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1097f821-56c3-4e51-bcd3-f84aef506e3a diff --git a/modules/Sample/generated/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum.yaml b/modules/Sample/generated/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum.yaml new file mode 100644 index 00000000..34a55c54 --- /dev/null +++ b/modules/Sample/generated/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum.yaml @@ -0,0 +1,13 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 1 entries +# Filters: species=Musmusculus, category=Spontaneously immortalized cell line, disorder=Neurofibromatosistype1 + +enums: + CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum: + description: 'Cell lines: Musmusculus + Spontaneously immortalized cell line + + Neurofibromatosistype1 (1 entries)' + permissible_values: + Dhh-Cre; NF1Arg681*/flox Schwann Cells: + description: '[From GFF:] Dhh-Cre; NF1Arg681*/flox Schwann Cells' + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae5651a-818f-4732-8045-17bea2555056 diff --git a/modules/Sample/generated/CellLineUnknownUnknownUnknownEnum.yaml b/modules/Sample/generated/CellLineUnknownUnknownUnknownEnum.yaml new file mode 100644 index 00000000..41eb946f --- /dev/null +++ b/modules/Sample/generated/CellLineUnknownUnknownUnknownEnum.yaml @@ -0,0 +1,19 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 2 entries +# Filters: species=Unknown, category=Unknown, disorder=Unknown + +enums: + CellLineUnknownUnknownUnknownEnum: + description: 'Cell lines: Unknown + Unknown + Unknown (2 entries)' + permissible_values: + HS-PSS: + description: A cell line previously identifed as MPNST, though recent 'omic + analysis suggests that it might not be. + meaning: rrid:CVCL_8717 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd49d4e2-575e-4e89-8317-cff02db4882c + HS-Sch-2: + description: A cell line previously identifed as MPNST, though recent 'omic + analysis suggests that it might not be. + meaning: rrid:CVCL_8718 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19bba596-fc3d-479b-9675-afa369b44dee diff --git a/modules/Sample/generated/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum.yaml b/modules/Sample/generated/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum.yaml new file mode 100644 index 00000000..42e067cc --- /dev/null +++ b/modules/Sample/generated/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum.yaml @@ -0,0 +1,16 @@ +# Auto-generated filtered enum subset +# Type: cell_line +# Count: 2 entries +# Filters: species=Xenopuslaevis, category=Spontaneously immortalized cell line, disorder=Noknowngeneticdisorder + +enums: + CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum: + description: 'Cell lines: Xenopuslaevis + Spontaneously immortalized cell line + + Noknowngeneticdisorder (2 entries)' + permissible_values: + XF: + meaning: rrid:CVCL_6E64 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2a2dca4-ebcc-4c8e-94c8-c867beaca9ab + XL110: + meaning: rrid:CVCL_T702 + source: https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0ee4d8e-2435-4e4a-bcc7-051d93fe686a diff --git a/modules/Sample/generated/animalmodel_Musmusculus.yaml b/modules/Sample/generated/animalmodel_Musmusculus.yaml new file mode 100644 index 00000000..7fbf3132 --- /dev/null +++ b/modules/Sample/generated/animalmodel_Musmusculus.yaml @@ -0,0 +1,305 @@ +# Auto-generated species-filtered model system enum +# System type: animal model +# Species: Mus musculus +# Count: 112 entries + +enums: + AnimalmodelMusmusculusEnum: + permissible_values: + "129-Nf1/Nci": + description: 'Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and ...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58b28d42-aa4f-496f-be70-257e8d1a95c6' + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+": + description: 'Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b8b5bd4-a085-4788-ae0e-dadf5def4b8b' + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-": + description: 'Generated via the F1 cross of 129T2/SvEmsJ male mice and C57Bl/6NTac Nf1+/- female mice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d59c28f-a132-4b3c-a52e-31da039647ca' + "B6-129S4-Nf1-/+;Trp53-/+cis": + description: 'B6X129S4 F1 hybrid' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9474c772-2e68-4f02-b0c8-f962f731d175' + "B6.129(Cg)-Nf1tm1Par/J": + description: '[From JAX]: These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I.' + meaning: 'rrid:IMSR_JAX:017640' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118aa95e-27f4-48fa-94c7-5f786b8b4f2f' + "B6.129S1-Nf1tm1Cbr/J": + description: '[From JAX]: Mice homozygous for this targeted allele (Nf123a-/-) lack the alternatively spliced exon 23a (which modifies the GTPase-activating protein (GAP) domain of Nf1). These mutant mice may be us...' + meaning: 'rrid:IMSR_JAX:007923' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=893695cf-daa7-42eb-998c-9b04af941964' + "B6.129S2-Nf1tm1Tyj/J": + description: '[From JAX]: Heterozygous animals do not exhibit the classical symptoms of Human neurofibromatosis type 1, but are highly predisposed to the formation of various tumor types, notably phaeochromocytoma,...' + meaning: 'rrid:IMSR_JAX:008192' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45638793-f2d0-4c40-8b1c-be1f1b0c0f93' + "B6.129S6-Nf1/Nci": + description: 'Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and ...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f9ca98a1-b5c5-423c-a4bd-db143975aa1c' + "B6.129S6-Nf1tm1Fcr/J": + description: '[From GFF:] GEM mouse in which Exon 31 of Nf1 has been disrupted in one allele' + meaning: 'rrid:IMSR_JAX:002646' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a0ccbed-abcd-49fa-abd0-5ff7b275a1e1' + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J": + description: 'EllaCre driver line.' + meaning: 'rrid:IMSR_JAX:003724' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5511a019-88aa-43c8-86c3-ad1677c8a3d0' + "B6/JGpt-Nf1/Gpt": + description: 'Conditional knockout' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27c1a639-9e98-4289-872d-f275d4e49be7' + "B6/JGpt-Nf1/Gpt": + description: 'Knockout' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a067f136-f956-4355-a76f-a5eec7c196f0' + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ": + description: '[From JAX]: These NPS+/- mice carry Trp53, Nf1, and Suz12 mutations on chromosome 11 (in cis) and develop high-grade gliomas and malignant peripheral nerve sheath tumors by approximately 3.5 months. T...' + meaning: 'rrid:IMSR_JAX:027678' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9b2d8ba-de9f-4bca-9401-fe100024deba' + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J": + description: '[From JAX]: These mice carry Trp53 and Nf1 targeted mutations on the same homolog of chromosome 11 (in cis). These mutations are approximately 10 Mbp apart and may segregate independently of one anoth...' + meaning: 'rrid:IMSR_JAX:008191' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d71c2b4-a7c5-4ced-bb45-eb98bfe42025' + "B6;CBA-Nf1/Flmg": + description: 'Mice with a mutated (possibly truncated) Nf1 protein were generated using CRISPR/Cas9 technology. The mutated protein is the result of a single nucleotide deletion that takes place at exon 38 close to...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=618a2f93-b45d-45bb-85f5-4a06929d5d8c' + "C3HeB/FeJ-Nf1/Ieg": + description: 'Induced Mutant Strain: Chemically-induced' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=af2241b2-2d00-476c-bfd1-e4ebf3a99ce6' + "C57BL/6-Nf1/Mmjax": + description: 'carry an R1276P missense allele' + meaning: 'rrid:MMRRC_041154-JAX' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b167141d-be0c-4f87-b767-956b24161b9c' + "C57BL/6JSmoc-Nf1em1Smoc": + description: 'Exon 21-23 of Nf1 gene was deleted to generate Nf1 knockout mice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d8c40468-ae43-4982-b079-5ff5e8ae104e' + "C57BL/6JSmoc-Nf1tm1(flox)Smoc": + description: 'These mice carry loxP sites flanking exon 31-32 of Nf1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nf1 g...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ddf3618d-dda5-4c03-a4b4-b9263dba0a31' + "C57BL/6N-Nf1/Mmucd": + description: 'ES cell clone EPD0033_1_F12 was injected into morulae or blastocysts. Resulting chimeras were mated to C57BL/6N mice and heterozygous tm1a (Knockout First) animals were generated.' + meaning: 'rrid:MMRRC_048792-UCD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2610c4cd-d622-4393-9087-0b007fa0567b' + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+": + description: 'Transgenic mouse expressing oncogenic\xa0N-ras\xa0specifically in central nerve cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06545c3d-e098-4a67-a678-6f023fda6b88' + "CisNf1+/-; p53+/-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27b4443a-06bb-454f-a253-ffb60b70a129' + "Cre(Col2.3Cre)": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19f93a61-f847-4479-ba8d-8b8a1cb3184b' + "Cx3cr1+/gfp": + description: 'wild-type mouse with reduced Cx3cr1 expression' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaf6e2b6-2e88-4ed1-8bfc-9b803ba2d718' + "Dhh-Cre; Nf1flox/+; Ptenflox/+": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d50930bc-c261-41a6-b517-548516044526' + "Dhh-Cre; Nf1flox/+; Ptenflox/flox": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=667881c8-e235-4d82-84af-2d1be9c6ef9b' + "Dhh-Cre; Nf1flox/flox; Ptenflox/+": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=caa4c07e-89d1-490d-a2a8-f63bf69bc5d3' + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=507595f1-9243-48d9-bc56-e9a97904789b' + "Dhh-Cre; Ptenflox/+": + description: 'Conditional Inactivation of Pten' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc6bf003-6330-4fc9-b851-8c6a3ada5d79' + "Dhh-Cre; Ptenflox/flox": + description: 'Conditional Inactivation of Pten' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8941ec-d5c8-42ae-9c1b-bc4066177ec3' + "Krox20;Nf1flox/-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6f865b65-5995-4243-8832-b8120fd2c36f' + "MPNST-Nf1-001": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=558a480a-0a0c-4e81-8735-2f90c7126bb0' + "MPNST-Nf1-002": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bcb3c61f-9f6d-4f04-8d5d-3ea1b63843a6' + "MPNST-Nf1-S462": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f587995-9831-4d51-99a3-a51b7607e83a' + "NF1SynIKO": + description: '[From GFF:] GEM mouse in which Nf1 is knocked out in neurons' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90c10d9a-c560-4722-8cbb-0e424bd417b7' + "NF1fl/fl;Dhh-Cre": + description: '[From GFF:] Mice with inactivation of NF1 in glial lineage cells beginning at E12.5' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bfa7ccaa-fee4-42bd-bc74-afe859d56fb6' + "NF1flox4/Arg681*;Dhh-Cre": + description: '[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) AND NF1 exon 4 floxed allele. Dhh-Cre...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=033b7173-4c58-410e-b441-579ba05c388a' + "Nf1 +/Δ4": + description: 'Mice harboring a null allele resulting from exon 4 deletion were created by breeding Nf1+/4F mice to an EIIaCre driver line (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J).' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9933922-29fb-4a4c-bc5f-604691a8bab7' + "Nf1 Arg681*/Arg681*": + description: 'Created by breeding Nf1 +/Arg681* (Nf1tm1.1Kest), is embryonic lethal at day 9.5.' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91e9130d-00bc-4dfe-9a5d-356e5ae3f4db' + "Nf1 GEM": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b07051a7-b584-45ae-82ad-f7bb85c1dea5' + "Nf1 Ocl-/-": + description: 'Nf1-deficient osteoclasts in otherwise Nf1+/+ background' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09880210-fe90-4af9-8b1f-f886348a34eb' + "Nf1 flox/+; DhhCre/+": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6159b19a-c94f-4001-887f-778a8fb1e685' + "Nf1 heterozygous mutant minipig": + description: 'heterozygous mutations in\xa0NF1' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02aba952-5860-4bd9-bfb2-ff796b22bf48' + "Nf1 Δ4/Δ4": + description: 'Created by breeding Nf1 +/Δ4, is embryonic lethal at day 9.5.' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8984594-d5ff-4827-8e83-13ccbf0055e8' + "Nf1(31)": + description: 'C57BL/6J mice with a targeted NF1 gene disruption mutation at exon 31 to mimic human\xa0NF1\xa0mutations, knockout mutation of Nfl' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e104ac3-b954-4afa-8d87-60c3b1d80b73' + "Nf1+/-": + description: 'heterozygous Nf1 mutant' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d27fd7b0-ed8f-4ee2-a8d9-26748c12518c' + "Nf1+/- P53+/-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9194d4de-84b2-438a-af6e-6cdfe79ff8cb' + "Nf1+/-GFAPCKO": + description: '[From GFF:] Mice heterozygous for a germ-line inactivating Nf1 mutation and a conditional knock-out of NF1 in astrocytes' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9971e47e-976a-4631-8edd-5cae04304b01' + "Nf1+/-x129S2/SvHsd": + description: 'one nf1 allele is deleted' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed66f5fd-52fd-4e83-8442-90b0676cf694' + "Nf1+/Arg681": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=118cc6d8-b656-4d6a-9cff-83f2ad92e2b0' + "Nf1+/R681X": + description: 'harbored a NF1-patient-derived Nf1 gene mutation (c.2041C>T;p.R681X)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8b964052-b74b-4ca3-ad82-31bd2f3457aa' + "Nf1+/ex42del pig": + description: 'heterozygotic mutation in NF1 (exon 42 deletion)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57625a6e-c039-418e-8e22-db464f8aa827' + "Nf1+/Δ4": + description: 'Heterozygous mice harboring a null allele resulting from exon 4 deletion' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3013cfbf-07fd-448e-8c57-cf25223eb0b4' + "Nf1-/+;Trp53-/+cis": + description: 'Nf1-/+;Trp53-/+ cis on mouse chromosome 11' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=426a3531-5785-4972-83ad-d88e54d2ef7f' + "Nf1-/-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b705a9f5-84ef-404e-9fe4-d499550298b3' + "Nf1-/- Drosophila": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=500a5c2f-5104-405e-a243-3d85b59d6b08' + "Nf1-/-MyoD": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02afeba7-05c6-48b1-9454-efe73d9b21f2' + "Nf14F/4F; DhhCre": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb4aff73-9da2-42b5-8f94-0a6084db75b0' + "Nf14F/4F;CAGGCre-ERTM": + description: '[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844c4e22-6d4d-454b-9ee4-53dcc7435e43' + "Nf14F/Arg681*": + description: 'Cre-negative\xa0Nf14F/Arg681*' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2a0345f-f0ba-4d72-99d7-f9ad2ea77751' + "Nf14F/Arg681*;CAGGCre-ERTM": + description: '[From GFF:] Mice with systemic inactivation of NF1 gene following tamoxifen induced activation of Cre transgene' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e70947db-35d1-448b-90d8-ec6f14e70303' + "Nf1:p53": + description: 'Nf1:p53 mouse tumor model' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8500990a-8848-413c-9c5b-7697d697fa2e' + "Nf1Dsk9/+": + description: 'Maintained on a mixed (C3HeB/FeJ x C57bl/6) background' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45756c39-61e8-48b6-ab0c-8f9ce9ad668a' + "Nf1E1 Drosophila": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=52351388-ba1f-4cf8-a03a-23b941d4408e' + "Nf1Fcr": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05c510fc-2ffc-457f-ba62-679c91799800' + "Nf1Gly848Arg/Gly848Arg": + description: 'Homozygous for missense c.2542G>C; p.Gly848Arg mutation' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4dfc91c9-31f4-4b00-a95e-4f1b26307339' + "Nf1P1 Drosophila": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc95a39a-5f41-4d34-9c0c-f312028aa2f3' + "Nf1P1/Nf1E1 Drosophila": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=326557dc-c320-4f04-b64a-08edd703ee95' + "Nf1Prx1-/-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a66bcb2-e137-4471-8cee-29dd9655b276' + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=757bf9d9-cf3c-400e-b470-d65302d22897' + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9cf037b-1743-4eef-88ff-8a80659323eb' + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3a1e3de-577d-4b4b-9eed-91dc21c1bbde' + "Nf1aL1247X zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cbc2b84-509f-44c6-b4f2-b77731ca34ef' + "Nf1adelta5 zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e7a8732a-73ba-4d05-88a9-8d796d0f1a6b' + "Nf1adelta8 zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=89b2f63c-1538-468e-9ca1-7ff948cb354e' + "Nf1b+10 zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d5e90cc-e97a-4321-b0a5-82feed840c50' + "Nf1bdelta55 zebrafish": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3853fe16-e6fe-4520-8e53-9845c1679fbf' + "Nf1flox/+;P0A-Cre(+)": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ed9ea80-e1fe-4224-bd67-594d9d0b0c7e' + "Nf1flox/-": + description: 'Nf1+/- mouse' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbeb0bb9-5341-496c-991a-de1e84af09b5' + "Nf1flox/-; GFAP-Cre; CD11b-TK": + description: 'Optic glioma mice with monocyte thymidine kinase expression' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d1c0c790-acff-486a-b794-b0429b09eeec' + "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp": + description: 'Optic glioma mice with reduced Cx3cr1 expression' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e487fd33-48d3-4a02-b2e0-4d0525ee8e20' + "Nf1flox/-;Col2.3Cre(+)": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9d41a9c-d779-4a05-b848-440287fa8b6b' + "Nf1flox/-;Cx3cr1+/gfp": + description: 'Nf1+/- mouse with reduced Cx3cr1 expression' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a2a52f7-e0e2-4654-9157-07848c8b0bcc' + "Nf1flox/-;Krox20-Cre": + description: 'peripheral nerves contain -/- Schwann cells and +/- mast cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46fb4411-d129-488c-83a5-c8e20176018e' + "Nf1flox/-;P0A-Cre-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=645fbd19-84c3-470e-bbf0-3cce94f0e6c9' + "Nf1flox/-;hGFAP-Cre": + description: '[From GFF:] Mice heterozygous for a germ-line Ex31-32 Nf1 mutation and a conditional knock-out of NF1 in astrocytes' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fbf11ec4-1d12-4feb-a6fc-9faf6bc9c9db' + "Nf1flox/flox; NG2-Cre": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2d103d-0d76-49aa-bf20-a17318184341' + "Nf1flox/flox;Cx3cr1+/gfp": + description: 'wild-type mouse with reduced Cx3cr1 expression' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e71b421a-5e1d-49d6-a045-aa03aff7e7fe' + "Nf1flox/flox;Islet1-Cre": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe8bd0a-f95f-46d5-b451-731c9155520b' + "Nf1flox/flox;Krox20-Cre": + description: 'peripheral nerves contain -/- Schwann cells and +/+ mast cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=441ea70d-e784-4fc0-a080-50e07acf5f05' + "Nf1flox/flox;P0A-cre-": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c1518d2-ea81-4cfc-bd3c-e3a6067053b1' + "Nf1flox/flox;PostnCre(+)": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=215b4e43-8a99-4702-ab4b-eeeadeeb13a5' + "Nf1flox/flox;Rac1flox/+;PostnCre(+)": + description: 'Generated by breeding Rac1flox/flox\xa0mice\xa0(129SV background) with\xa0Nf1flox/flox;PostnCre+\xa0mice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59c9a1fc-9754-40b3-8169-c2185b522a75' + "Nf1flox/floxRac1flox/flox;PostnCre(+)": + description: 'Generated by breeding Rac1flox/flox\xa0mice\xa0(129SV background) with\xa0Nf1flox/flox;PostnCre+\xa0mice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3ae87c9-2734-4809-a08a-9212cf278437' + "Nf1flox/mut": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ff3a2b6-110b-4352-8abf-74b46c7e55ce' + "Nf1flox/mut; GFAP-Cre": + description: 'NF1 conditional knock out' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4e513b5b-dde9-424d-96ff-3dd7c90f429b' + "Nf1flox/mut; NG2-Cre": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=669641d6-2e7c-4679-bfe8-0d31c53c2dfc' + "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=92a431bb-182a-4f6a-92a5-4509888e2102' + "Nf1pArg1947mp1": + description: '[From GFF:] Minipig model containing a recurrent nonsense mutation p.Arg1947*(R1947*) and HindIII RFLP site resulting in frame shift mutation' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=209c16d7-c1fa-414f-8f08-458eaefc2259' + "Nf1tm1.1Kest": + description: '[From GFF:] A nonsense mutation recapitulating the human variant c.2041C>T in which an arginine at position 681 was changed to a chain-terminating codon (Arg681*) was introduced in exon 18 and a FRT-f...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504d7dfe-acf9-476c-974d-e8665095afbb' + "Nf1tm1a(KOMP)Wtsi": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85b32836-b4c6-4f72-b0d5-a9f192fe2806' + "Nf1tm1c(KOMP)Wtsi": + description: '[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele.' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=361988eb-d390-4f40-b01b-acee637e2271' + "Nf1tm1d(KOMP)Wtsi": + description: '[From GFF:] EUCOMM identified critical exon 4 is flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ecabd72-d36c-487e-8c0e-c05e3dd743ba' + "Nf1tm2.1Kest": + description: '[From GFF:] \xa0A point mutation, recapitulating the human missense variant c.2542G>C, in which a glycine residue at position 848 was changed to an arginine (p.Gly848Arg), was introduced in exon 21 and a...' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e5c372e-dec8-4693-98a8-b07f3014257d' + "PlpCre;Nf1flox/+": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5359b57-3b0a-460d-900b-dbd7cc2af7d3' + "PlpCreERT; Nf1flox/flox; eGFP": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b0b57e3-bc2d-4f0a-b42f-213be95ce457' + "Prx1-Cre+/- Nf1flox/+": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be5c22d-862e-4739-a214-89546880a840' + "Prx1-Cre+/- Nf1flox/flox": + description: 'homozygous knockout' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b0e4be7c-1b0f-4564-aa18-05b36ac77055' + "dNf1 Drosophila": + description: 'Homozygous dNf1 null mutants' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7b76ccd-e646-4d30-8868-ba39541dd573' + "miR-155 +/-;Nf1flox/+": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2470d9dd-b6c8-4cdb-ad2e-009071477c41' + "miR-155 +/-;Nf1flox/+;DhhCre": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a79e9847-1e32-41c8-a176-adf96a8547c0' + "miR-155 -/-;Nf1flox/flox ;DhhCre": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6e61b912-8006-48cb-a122-df613c8921c4' diff --git a/modules/Sample/generated/animalmodel_Unknown.yaml b/modules/Sample/generated/animalmodel_Unknown.yaml new file mode 100644 index 00000000..8559a0b3 --- /dev/null +++ b/modules/Sample/generated/animalmodel_Unknown.yaml @@ -0,0 +1,36 @@ +# Auto-generated species-filtered model system enum +# System type: animal model +# Species: Unknown +# Count: 10 entries + +enums: + AnimalmodelUnknownEnum: + permissible_values: + "Cnp-EGFR (Pten-het/C-EGFR)": + description: 'EGFR overexpression in Schwann cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2934805f-67ef-41d9-af89-64a072c66642' + "Cnp-EGFR (deltaPten/C-EGFR)": + description: 'EGFR overexpression in Schwann cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98e86631-5d93-4b4a-862a-d2758420674a' + "DelE17": + description: 'homozygous deletion of NF1 exon 17' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e00317c8-ff2c-453b-9d71-c8bf3f50a600' + "MPNST-SP-001": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41c369b5-25f3-4285-829f-5481b41b230e' + "MPSNT-SP-002": + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2cc7762-5e1a-45d6-a4ce-029be9b42094' + "NCC-MPNST3-X2": + description: 'A patient-derived xenograft model created using the NCC-MPNST3-C1 cell line. This xenograft model was used to generate the NCC-MPNST3-X2-C1 cell line.' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8a807e4-502b-461c-a60f-fd10b3cde70e' + "P0-GGFb3": + description: 'overexpress the growth factor neuregulin-1 in Schwann cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=57d32b42-8034-4ea4-a14b-78f285eed3c8' + "Spred1+/-": + description: 'Heterozygous loss-of-function SPRED1 mutation' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a8c3628-fce7-4219-825b-5551f223754d' + "Spred1-/-": + description: 'SPRED1 knock-out' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4f433c0f-2c9b-41f7-9b04-ff32f524b55b' + "delta-ira1 delta-ira2 yeast": + description: 'delta-ira1 delta-ira2 double-knockout yeast' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b2a7ee1-e462-42b9-80b8-0a64ca60b091' diff --git a/modules/Sample/generated/cellline_Homosapiens.yaml b/modules/Sample/generated/cellline_Homosapiens.yaml new file mode 100644 index 00000000..7fa2f1f7 --- /dev/null +++ b/modules/Sample/generated/cellline_Homosapiens.yaml @@ -0,0 +1,926 @@ +# Auto-generated species-filtered model system enum +# System type: cell line +# Species: Homo sapiens +# Count: 268 entries + +enums: + CelllineHomosapiensEnum: + permissible_values: + "Abcam MCF-7 NF1 KO": + description: 'Nf1 knockout cell' + meaning: 'rrid:CVCL_B8ZE' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24719e11-8ac2-452c-9424-20d75fc26d82' + "ELK-TAD Luciferase Reporter HEK293 Stable": + description: '[From GFF:] ELK-TAD Luciferase Reporter HEK293 Stable' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c88fcbc9-24c1-4f2b-8d13-02f5037dcf1c' + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3239573e-4ae1-4e01-8098-00dce6ac0a84' + "GM00622": + description: 'Fibroblast from an NF1 patient' + meaning: 'rrid:CVCL_5M64' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1edebf4d-8ea4-4071-90bf-7e934c7ab029' + "GM01633": + description: 'Fibroblast from an NF1 patient' + meaning: 'rrid:CVCL_9Z54' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa663228-7ffe-4604-9cda-95b29b8d7386' + "GM01634": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z57' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9722c74b-e82e-4ac7-b684-4bab1a409a78' + "GM01639": + description: 'Fibroblast from an NF1 patient' + meaning: 'rrid:CVCL_5M68' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2677690-2137-408e-b250-784a0cd235f4' + "GM01641": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_5M69' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9db66052-f458-4400-ae1b-3f5c075dbd25' + "GM01858": + description: 'Fibroblast from Neurofibroma from an NF1 patient' + meaning: 'rrid:CVCL_9Z58' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4e97f99-a857-4f2d-80f1-62de8a12d037' + "GM01859": + description: 'Fibroblast from Neurofibroma from an NF1 patient' + meaning: 'rrid:CVCL_9Z59' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3899a07c-6fb8-4fc2-997f-c2301d6082f7' + "GM01861": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z60' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46cc2e4e-d9bf-4474-b4de-448e25fb0c66' + "GM03420": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z61' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ebbfa6b-049f-4e85-af96-be49c3b5b31a' + "GM03421": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z62' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5570368b-f20e-47ed-9656-0b9d49c53c9f' + "GM09534": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z63' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4106cadd-2071-437e-8c43-6f5751332128' + "GM09535": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z64' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bdf2270-d002-41bf-b75d-2a1d890f9967' + "GM09536": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z65' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=afcff3ca-6421-4c66-bd87-94ad21493b1d' + "GM09539": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z66' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f77c8f5-a9a2-4d1a-a34a-79e912718c91' + "GM09616": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z67' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c569a3f9-9c0c-48fe-bbb5-7ae5cb6c384a' + "GM09617": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z68' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f34019e4-be8b-4f75-9f68-a79032c8705b' + "GM09618": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_N114' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a9d486c-1cd0-4cab-b3d7-cbe17058d457' + "GM09619": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z69' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bdd8125b-cf6d-45f3-8cea-20af6e21a1da' + "GM09620": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z70' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=559404ce-6df0-4109-bdeb-6521d8928f1c' + "GM09621": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z71' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=026b1ceb-5f1c-4497-825c-ee3cc5d9d2ed' + "GM09622": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z72' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4cf20b8-9e30-4798-8281-25b83346458d' + "GM09625": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z73' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0843b842-e9d2-4b23-9a53-aebf01ae31e3' + "GM09626": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_N115' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=59bac805-44b6-4397-8195-6005fcedcd95' + "GM09627": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z74' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96456d2b-062d-42ab-a1ce-ff3df6f7ab5b' + "GM09628": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z75' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b636771-68eb-4a86-801e-546bcb4f9b25' + "GM09629": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z76' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86145b27-da2e-4b32-9ddc-e247374fe10e' + "GM09630": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z77' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5be65ffe-18cb-46c4-b910-6e5a3cc5612a' + "GM09631": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z78' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22ca8958-b953-461d-9301-016f57cd08a5' + "GM09632": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z79' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a28aea84-6495-4863-80cc-08066079deef' + "GM09633": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z80' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cba1c774-499d-4d01-b3d2-a62f670b03ce' + "GM09634": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z81' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=327fcda4-f2ef-4cb5-9245-d3256960f17f' + "GM09635": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z82' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9d1561b3-b430-4a9b-984d-1c77a02f1a23' + "GM09636": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z83' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5b213001-31a3-4c59-bf32-4e5407c01e82' + "GM09637": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z84' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fd4f461-6137-4922-81b1-e9f30d993df1' + "GM09638": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z85' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f00ae7c4-4eea-49e4-92d1-43382dfd31bb' + "GM09639": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z86' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd411ce0-865d-47d7-a5c4-84084f5aadb5' + "GM09640": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z87' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6a894263-7e2b-46f5-81b1-9aa351590843' + "GM09641": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z88' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc42f6e8-494c-49ff-880f-be2352f3a87e' + "GM09642": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z89' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6d3fc47-cd5d-4b7e-a5b7-7c10cecb2490' + "GM09649": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z90' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4996ae57-c5df-4832-8990-cea9133004bc' + "GM09650": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z91' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b16247aa-fd06-4103-9f5e-50e0e7d06805' + "GM09651": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z92' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=432fefde-722b-44f0-8f11-bbc97920b5f6' + "GM09652": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z93' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08309e7c-d0a5-457e-91bc-9c5113347ee2' + "GM09688": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z94' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09799642-3547-4033-a094-5ba1dd08da60' + "GM09689": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z95' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=220c8dae-1759-4834-b952-c9b68469137a' + "GM09690": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z96' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41307a11-4252-4563-bb7d-afe570cf1620' + "GM09691": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9Z97' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7df4a356-0194-47d4-9a78-291b8083ed18' + "GM09692": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z98' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c83b346e-57de-41b3-9a28-7e60a2f78483' + "GM09693": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_9Z99' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1dbbb94-a4e6-4829-a3db-455480b0a535' + "GM09694": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_6F53' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6b2e6bfa-e869-4970-a71c-10abd3224ea9' + "GM09886": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9T23' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f597b96-5566-45f6-81c6-592c82cb3465' + "GM09887": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_9X49' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed96e95-c815-4151-ade9-40510601255f' + "GM09944": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_AA00' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0abcee2-581c-4c1a-9ef8-93b57dd0f96d' + "GM10501": + description: 'Human/rodent somatic cell hybrid' + meaning: 'rrid:CVCL_1R95' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1457a4e1-4ef4-41d6-b5f2-69f6b5d9dbfb' + "GM10502": + description: 'Human/rodent somatic cell hybrid' + meaning: 'rrid:CVCL_1R96' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb9845e1-c1fc-4ad5-b635-92f73ae71965' + "GM10657": + description: 'Human/rodent somatic cell hybrid' + meaning: 'rrid:CVCL_1R97' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4bfd3c0a-cb7c-428e-9f57-9694cb1bd3c7' + "GM10659": + description: 'Human/rodent somatic cell hybrid' + meaning: 'rrid:CVCL_1R98' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a10db87-b73f-464b-a709-ac16677ee7b3' + "GM11601": + description: 'Leukemia cell line derived from B-lymphocytes from an NF1 patient.' + meaning: 'rrid:CVCL_AA01' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2f62c57-a1b8-4867-9c91-04406f261cfa' + "GM11602": + description: 'Leukemia cell line derived from B-lymphocytes from an NF1 patient.' + meaning: 'rrid:CVCL_AA02' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f354ec1a-0305-4e6c-897a-10e4fba10a28' + "GM12517": + description: 'Human/rodent somatic cell hybrid' + meaning: 'rrid:CVCL_1S66' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0b77b4e-ff5c-4736-aff9-02da9f50fe81' + "GM21674": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_HL11' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2e3f513-8780-4f7e-985a-4dd4eab7de95' + "GM21675": + description: 'Fibroblast derived from skin from an NF1 patient' + meaning: 'rrid:CVCL_HL12' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf150ecf-4971-4500-ae94-5d25e4895d63' + "GM21843": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_BA07' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4280272c-022d-45bd-9c0f-20d96b69aba8' + "GM21844": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_BA08' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7c5369fa-2ea8-45a1-93be-d6e22e1ac695' + "GM21845": + description: 'Lymphoblastoid cell line derived from B-lymphocytes' + meaning: 'rrid:CVCL_BA09' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3281d1ba-5d0d-4dca-b583-9c610814fb76' + "GM21865": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_BA10' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=38dcffa4-463a-482b-8d6c-5d787ac3a1c4' + "GM22279": + description: 'Fibroblast from an NF1 patient' + meaning: 'rrid:CVCL_BA11' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ba4aabde-a800-4cca-b4de-1f4f4c8c06cc' + "GM22606": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_BU80' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=809601e0-75ef-460c-9e95-9c454e06c474' + "GM22607": + description: 'Fibroblast derived from skin from an NF1 patient' + meaning: 'rrid:CVCL_BU81' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bc4c4f3b-34c3-447f-9422-0262d7b43ae5' + "GM22608": + description: 'Lymphoblastoid cell line derived from B-lymphocytes from an NF1 patient' + meaning: 'rrid:CVCL_BU82' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce964197-a694-41fb-8f25-66cd84c86e50' + "GM22609": + description: 'Fibroblast derived from skin from an NF1 patient' + meaning: 'rrid:CVCL_BU83' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f18f5f6b-09c7-4367-89d5-c065137888db' + "GM23312": + description: 'Tumor-derived cell line from chest an NF1 patient' + meaning: 'rrid:CVCL_CW86' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b104c61a-5a55-4811-97fc-7ce0683b2a14' + "GM23338": + description: '[From GFF:] iPSC NF1 WT, PGP1 cells' + meaning: 'rrid:CVCL_F182' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c4e4b03-5975-4708-a25c-f6c45cbe3abf' + "HEK293": + description: '[From ATCC:] This is a hypotriploid human cell line.' + meaning: 'rrid:CVCL_0045' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7b6dcc42-3c32-4008-8b2c-309aa01b17be' + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice": + description: '[From GFF:] HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae765b00-9189-4a72-8ae7-cddc41e24055' + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice": + description: '[From GFF:] HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b4b8eca-f981-440d-b478-0a5483353368' + "HEK293 NF1 -/- Exon 47 insT #14": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 47 insT #14' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=130fd347-28e1-46c2-a72d-d243e99322b7' + "HEK293 NF1 -/- Exon 52 R2550X #5": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- Exon 52 R2550X #5' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d565aea-0917-428b-9101-d2a19f3fbcf1' + "HEK293 NF1 -/- clone 2": + description: '[From GFF:] HEK293 NF1 -/- clone 2' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f59f3308-a440-497d-8eee-8d7756a9ae2b' + "HEK293 NF1 -/- with R1306X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1306X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=02dacc42-ea46-48fb-a4df-7a875d801086' + "HEK293 NF1 -/- with R192X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R192X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb67363f-d309-4c7c-ba1e-f295ba411018' + "HEK293 NF1 -/- with R1947X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R1947X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14353c91-2be9-4617-b337-c29080961826' + "HEK293 NF1 -/- with R2550X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R2550X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aa32fc67-9cc3-4d31-bcbd-f7044f9fd484' + "HEK293 NF1 -/- with R461X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R461X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f29aa26-1d05-453a-a6ac-d4e37d609dba' + "HEK293 NF1 -/- with R681X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R681X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=32f73d96-fd2a-4966-a150-ba5fa47d150c' + "HEK293 NF1 -/- with R816X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with R816X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f047cff6-98c8-4562-b589-94b864ae35a1' + "HEK293 NF1 -/- with WT mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2d00598-9db3-4549-a473-16b1db349614' + "HEK293 NF1 -/- with WT tagged mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. HEK293 NF1 -/- with WT tagged mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96d339f9-9d19-40c3-8f81-3590f7c00205' + "MCF10A_NF1_1": + meaning: 'rrid:CVCL_C1A6' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd6b1f88-b716-47d4-9869-84d58b18c2eb' + "MCF10A_NF1_7A1": + meaning: 'rrid:CVCL_C1A7' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f506b298-5b5e-4ea6-abe3-49b4f69d871b' + "MCF10A_NF1_7B2": + meaning: 'rrid:CVCL_C1A8' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b7e0c9b3-008d-415f-bd1e-8fc33d55e497' + "MPNST 724": + description: 'human MPNST cell line' + meaning: 'rrid:CVCL_AU20' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7db6b49f-7eec-4b47-bbdc-675a8a464735' + "MPNST-14": + meaning: 'rrid:CVCL_AU21' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=81ae2a05-5102-473f-88fa-9d9bbe8fd35e' + "MPNST-642": + meaning: 'rrid:CVCL_AU19' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=818f4c93-dbd3-41f7-b557-f264f7949c6e' + "MPNST-90": + meaning: 'rrid:CVCL_J355' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd3db98f-0ec9-40df-bc06-5e314c0fc671' + "MPNST-91": + meaning: 'rrid:CVCL_J356' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fd09582-99a8-40d5-a16b-b250a6975e44' + "MPNST-92": + meaning: 'rrid:CVCL_J357' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fa12d6e9-6547-43ad-a666-c17c7c1a9cb3' + "NCC-MPNST1-C1": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_YU12' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc3ae45e-9a5b-4fa5-8430-f53479f07f5a' + "NCC-MPNST2-C1": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_YU13' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f646e44-5263-4f80-bb94-b297a875c52a' + "NCC-MPNST3-C1": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_YU14' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7fe31236-bc93-449b-b559-9394999be926' + "NCC-MPNST3-X2-C1": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_YU15' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b604846-d41c-4969-a79a-9660c04e585c' + "NCC-MPNST4-C1": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_YU16' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f17b839e-acd9-4dbc-a5bb-7d72ed0d0bd8' + "NCC-MPNST5-C1": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_YU17' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=827f08a1-3d0f-4fd8-98e4-fb5c40a9c742' + "Nf1-/- HEK 293": + description: '[From GFF:] Nf1-/- HEK 293' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=44f9c496-ddd8-4e4b-bddb-6b93f7e04fc2' + "SK-MEL-105": + meaning: 'rrid:CVCL_6070' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b6cfa68c-9b94-4c77-8ef2-6753e595ea59' + "SK-MEL-109": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6073' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c8c2065-4781-4275-88bc-c300d6fce45a' + "SK-MEL-11": + meaning: 'rrid:CVCL_D702' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be7ecfd3-30cc-4ed3-b923-92ad62970441' + "SK-MEL-110": + description: 'Mutation of KRAS, p.Glu63Lys (c.187G>A), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_3875' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e1a6df94-feec-421c-a865-12d27212fd62' + "SK-MEL-113": + meaning: 'rrid:CVCL_6074' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eabae967-3d0b-4d26-848f-83e0b7d3f646' + "SK-MEL-117": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6075' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42c32d24-0d9e-48f9-84fe-6b68ea76d4b3' + "SK-MEL-118": + meaning: 'rrid:CVCL_6076' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a92babaf-c310-4c73-8d35-c8942a60272c' + "SK-MEL-119": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=10766161, PubMed=15009714, PubMed=24576830).' + meaning: 'rrid:CVCL_6077' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=67795a20-8d41-4a1c-a79d-ee6b4e02b00f' + "SK-MEL-12": + meaning: 'rrid:CVCL_6021' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a739a670-527d-4be6-9e3a-66366b8a5242' + "SK-MEL-127": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6078' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08684da1-cd81-4616-baef-5b37ee641eb3' + "SK-MEL-13": + meaning: 'rrid:CVCL_6022' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7765fe-7681-40cb-8a72-6f6d5204985e' + "SK-MEL-130": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6080' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7e9b741c-b0af-4c12-a1c0-9dd23facb95e' + "SK-MEL-131": + meaning: 'rrid:CVCL_6081' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=091b8721-27f6-4a7b-ab85-833aa57a61c3' + "SK-MEL-133": + meaning: 'rrid:CVCL_6082' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=896db229-428a-447b-b37d-b2b7c405545d' + "SK-MEL-146": + description: 'Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_6085' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=80e1cac7-712d-4333-9d09-27e8cce3d46d' + "SK-MEL-15": + meaning: 'rrid:CVCL_6964' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d269f40c-b3e7-4dc7-9c40-28ba1f9711cf' + "SK-MEL-153": + meaning: 'rrid:CVCL_6087' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be99815b-bab0-49e1-b281-3163d4c34be5' + "SK-MEL-161": + meaning: 'rrid:CVCL_6088' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615ef245-4753-4a2d-9e37-013f5c0411c4' + "SK-MEL-170": + meaning: 'rrid:CVCL_6089' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3e11e0d-a7bf-491e-badd-88404b403caf' + "SK-MEL-174": + meaning: 'rrid:CVCL_6091' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54970293-b923-4058-baee-abea1f0154e8' + "SK-MEL-176": + meaning: 'rrid:CVCL_6092' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e712f46a-4e8d-48bd-87e6-1329b358e178' + "SK-MEL-178": + meaning: 'rrid:CVCL_6093' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a3ad8165-42aa-4e9b-8403-3df16139b535' + "SK-MEL-181": + meaning: 'rrid:CVCL_6094' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a71bce03-eef0-422c-b327-6c79cf634bbe' + "SK-MEL-182": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6095' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0b3d75cd-ed20-4fe4-b588-317a870ca687' + "SK-MEL-186": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6096' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a2d5cbfd-18e1-4755-b2e9-1d3df322aa60' + "SK-MEL-188": + description: 'Pigmented.' + meaning: 'rrid:CVCL_6098' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2df52df1-44ae-4897-afc9-cbbc997a73ca' + "SK-MEL-190": + meaning: 'rrid:CVCL_6099' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1dff78ed-20a6-4df8-ba2c-4979eef85cf8' + "SK-MEL-191": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6100' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=446e95ac-2716-4a3b-8294-74f1a3ba38b0' + "SK-MEL-196": + meaning: 'rrid:CVCL_6102' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3967dcb7-a32f-4437-bc30-21e9d1b27d5b' + "SK-MEL-199": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6104' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=545a4d43-e5ec-4989-9f7f-f5274248072c' + "SK-MEL-200": + meaning: 'rrid:CVCL_6105' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4ce28266-8fbc-48f1-8e17-35719865102d' + "SK-MEL-202": + meaning: 'rrid:CVCL_6106' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=389f4f77-8faf-46b8-9ae2-91e26844bfc3' + "SK-MEL-205": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6107' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d557680-ae5b-4345-8742-d0cc4a6318a2' + "SK-MEL-207": + meaning: 'rrid:CVCL_6108' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8f02bdc8-5936-495a-af4b-0b94b14dfe2c' + "SK-MEL-208": + meaning: 'rrid:CVCL_6109' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c8801096-624b-463a-90b3-143a4dd8d504' + "SK-MEL-209": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6110' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a56209e-d090-4f66-bf8c-66eafa35bcfe' + "SK-MEL-21": + description: 'Very highly pigmented. Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_3877' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4d34543-1c7d-4c58-adf7-3f60a1df91d4' + "SK-MEL-210-3": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_D772' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f23a835-e46f-4e7e-9643-1ad7264ca35d' + "SK-MEL-215-1": + meaning: 'rrid:CVCL_U911' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2805574-fdd3-40d5-bf01-ed5e4c32498f' + "SK-MEL-217": + meaning: 'rrid:CVCL_6111' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f4ac84fa-aadd-4a36-9aca-d1bc1e7a4c3e' + "SK-MEL-22": + meaning: 'rrid:CVCL_6026' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d53de27-93dd-4421-8612-2e3402106ee7' + "SK-MEL-222": + meaning: 'rrid:CVCL_6112' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46b0bf61-f688-43b7-97f6-29f3462b9313' + "SK-MEL-227": + meaning: 'rrid:CVCL_6113' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=210a3450-b6ff-4a15-b6b7-415d96246d1b' + "SK-MEL-228": + meaning: 'rrid:CVCL_6114' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de2d02b5-5406-488f-bd57-03efcec737a9' + "SK-MEL-229": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6115' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05280043-5ac8-4427-9e19-f53c8efd260e' + "SK-MEL-23": + description: 'Very highly pigmented.' + meaning: 'rrid:CVCL_6027' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d6345dc-0415-4afe-965d-683c2f7fb6f3' + "SK-MEL-230": + meaning: 'rrid:CVCL_6116' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=318b6745-af78-435e-9bd2-83fa22cf8c7b' + "SK-MEL-232": + meaning: 'rrid:CVCL_6117' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a689488c-6aa3-4c3e-ab74-a58348944338' + "SK-MEL-233": + meaning: 'rrid:CVCL_6118' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f927ed06-7d0e-43af-9031-dbedfc2c42d3' + "SK-MEL-234": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6119' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7935406-82be-4ed6-82fe-0f387439cd4f' + "SK-MEL-237": + meaning: 'rrid:CVCL_6120' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efd49881-3065-4fff-a296-8dc1ea2f63b7' + "SK-MEL-238": + meaning: 'rrid:CVCL_6121' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24f0992a-00ed-4a1f-b8f5-72e42cb8556d' + "SK-MEL-239": + meaning: 'rrid:CVCL_6122' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0128a62c-13f8-485e-802d-c4c3e1ef7905' + "SK-MEL-243": + meaning: 'rrid:CVCL_6123' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4386a81c-a396-4600-a972-2b993cb9af0e' + "SK-MEL-244": + meaning: 'rrid:CVCL_6124' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=363d82b8-97ac-429a-b9d6-e195fb764e5c' + "SK-MEL-246": + meaning: 'rrid:CVCL_6126' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4adf5880-df01-4b08-aed3-11366ca77f42' + "SK-MEL-252": + meaning: 'rrid:CVCL_6127' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b1e67f2-410d-4a22-822d-c812003f6312' + "SK-MEL-256": + meaning: 'rrid:CVCL_6128' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31d0179a-4cd5-4454-a035-ef02f0ef284b' + "SK-MEL-264": + meaning: 'rrid:CVCL_6131' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ff17bb4d-4cb0-4366-8d6b-e59a7ad73837' + "SK-MEL-265": + meaning: 'rrid:CVCL_6132' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c7aa452-e44e-48b4-b57e-f0f11493c389' + "SK-MEL-266": + meaning: 'rrid:CVCL_6133' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffc1bc88-d5ec-4b2f-a36b-6052f9d736b7' + "SK-MEL-267": + meaning: 'rrid:CVCL_6134' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=58864ae6-c1da-409e-a473-afbe769e35d0' + "SK-MEL-268": + meaning: 'rrid:CVCL_6135' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a012aa8a-d3ab-4f4b-86dc-61c137f3b6b7' + "SK-MEL-269": + meaning: 'rrid:CVCL_6136' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3edcb81d-31b5-4366-b5ad-69ec792df1c5' + "SK-MEL-27": + meaning: 'rrid:CVCL_6030' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e30707fe-357d-4aa8-92e9-8f2db981ef78' + "SK-MEL-271": + meaning: 'rrid:CVCL_6137' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d3b2a72b-66a5-4fcd-9200-4442c5c51a69' + "SK-MEL-272": + meaning: 'rrid:CVCL_6138' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4af69cf3-041f-46d0-8b20-cd5170ce42a7' + "SK-MEL-275": + meaning: 'rrid:CVCL_6139' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3571655-7dfb-4364-9d61-aebe2ae4039e' + "SK-MEL-276": + meaning: 'rrid:CVCL_6140' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7c386a0-ee01-4ad2-9772-1c29715e26a3' + "SK-MEL-279": + meaning: 'rrid:CVCL_6141' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5176605-b22b-45d6-b636-2be6faff0a13' + "SK-MEL-282": + meaning: 'rrid:CVCL_6143' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0c81c271-14ab-4f29-b006-b2a71dce3009' + "SK-MEL-283": + meaning: 'rrid:CVCL_6144' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=533ec9c8-8391-4979-9b39-e65cef5f9423' + "SK-MEL-284": + meaning: 'rrid:CVCL_6145' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06aaab7a-7e1e-4ad0-b4c2-14245c60a927' + "SK-MEL-285": + description: 'Mutation of KRAS, p.Gly12Cys (c.34G>T), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_6146' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=62654a64-d223-4d52-81e1-6869e071bc52' + "SK-MEL-301": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6147' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=22c9daa2-d3bb-4e9d-b615-45fdd7506ae5' + "SK-MEL-304": + meaning: 'rrid:CVCL_6148' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b24851b4-c7b9-4265-b3dd-8cdd6ff1df6b' + "SK-MEL-306": + meaning: 'rrid:CVCL_6149' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c89cb4de-6160-452d-b8f9-054250e25207' + "SK-MEL-307": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6150' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6c7e09f2-b4a4-4e21-a346-8d46c7815a25' + "SK-MEL-309B": + meaning: 'rrid:CVCL_U912' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64f2ff80-3b84-4d42-985a-c7290ffb1ed3' + "SK-MEL-313": + meaning: 'rrid:CVCL_1T59' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ebc58516-eb4c-4b8a-ac75-1ad3cc9ec258' + "SK-MEL-315-02": + meaning: 'rrid:CVCL_E090' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b05001f1-b471-4d98-925b-521c4cbaf31d' + "SK-MEL-315-05": + meaning: 'rrid:CVCL_E092' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9906bf3-21a5-4cef-9119-02b25b4a556f' + "SK-MEL-316": + meaning: 'rrid:CVCL_6151' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=231c785d-ad45-4395-b7b9-64c734a79fd1' + "SK-MEL-318": + meaning: 'rrid:CVCL_1T60' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=05799982-53b2-4872-990d-9d79fdfcae38' + "SK-MEL-32": + meaning: 'rrid:CVCL_6032' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423ba382-0958-4015-a4f3-c01f29442df1' + "SK-MEL-321A": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_D771' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=11b6440f-fe1b-49be-835e-e3d063daba0e' + "SK-MEL-321B": + meaning: 'rrid:CVCL_E089' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=145c4d7f-81de-436c-801b-15cc2298895d' + "SK-MEL-323": + meaning: 'rrid:CVCL_6152' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5133ef-e87d-4026-a9b5-56ece87fde75' + "SK-MEL-325": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6153' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5cd8c18c-d03e-4129-913a-ab50484aa8ef' + "SK-MEL-326": + meaning: 'rrid:CVCL_6154' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84aa6e1a-1d68-4923-beea-af84d7593a3e' + "SK-MEL-330": + meaning: 'rrid:CVCL_6155' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f6aef573-0840-4920-b66a-0b361a22d92b' + "SK-MEL-332": + meaning: 'rrid:CVCL_1T61' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a01e27d8-a50e-49c1-9a5d-5202460b94c2' + "SK-MEL-334": + meaning: 'rrid:CVCL_6156' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a065ee27-ac39-4fe2-82a2-8c92011f6b23' + "SK-MEL-339": + meaning: 'rrid:CVCL_6157' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1b58976e-5983-411b-b193-75a16c63dfb9' + "SK-MEL-346": + meaning: 'rrid:CVCL_6159' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e465de74-8162-4b07-a5b9-2004fee28873' + "SK-MEL-35": + meaning: 'rrid:CVCL_6034' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=24a85352-2025-4ba8-a8e4-9db6150c35ea' + "SK-MEL-351": + meaning: 'rrid:CVCL_6160' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce3b913-11dc-4827-8cd8-46b4fae21993' + "SK-MEL-359": + meaning: 'rrid:CVCL_6161' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce242fc6-c98c-47fb-ab26-876ad418a8dc' + "SK-MEL-36": + meaning: 'rrid:CVCL_6035' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20fd4d84-bcf4-4016-84e6-904c8ab5d931' + "SK-MEL-364": + meaning: 'rrid:CVCL_6162' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86d7407c-c680-4866-a5c2-bc77e0488c6f' + "SK-MEL-366": + meaning: 'rrid:CVCL_6163' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46ea3bf7-34ca-48ab-8e55-e2eb1221c741' + "SK-MEL-367": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6164' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13938786-687b-4476-845f-04a0533aac60' + "SK-MEL-369": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6165' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=153a917d-42f2-4fa3-af4a-fa2d9aeea185' + "SK-MEL-380": + meaning: 'rrid:CVCL_6166' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49c46106-2a7b-420f-ab36-3501ee7aede4' + "SK-MEL-381": + meaning: 'rrid:CVCL_6167' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee3cbd77-c4f4-46e3-b4c3-0bf945215117' + "SK-MEL-39": + meaning: 'rrid:CVCL_6036' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=615c7563-d62b-4d4e-9852-6ba6ee5e1bb2' + "SK-MEL-390": + meaning: 'rrid:CVCL_6168' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1829be6d-fdc2-44eb-a1d1-32678faeb6c7' + "SK-MEL-391": + meaning: 'rrid:CVCL_1T62' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86212d03-fe40-45e2-8fbf-587cd052b194' + "SK-MEL-393": + meaning: 'rrid:CVCL_1T63' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9e7f25d9-7b2b-4272-9c80-dfaf030f0b36' + "SK-MEL-394": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_1T64' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3fa847e6-2be0-4b0d-bdab-630aaf9a10d4' + "SK-MEL-398": + meaning: 'rrid:CVCL_1T65' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a4ec3ce-a757-43ad-9c54-0999f94c4a10' + "SK-MEL-40": + meaning: 'rrid:CVCL_6037' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a997c565-7bda-4a81-a7cf-800d1612598e' + "SK-MEL-400": + meaning: 'rrid:CVCL_1T66' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f4941d-ed79-41f1-9a2a-a494baed6d7b' + "SK-MEL-406": + meaning: 'rrid:CVCL_1T67' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=935f7b60-4c34-4fc9-a877-ec901f25f162' + "SK-MEL-408": + meaning: 'rrid:CVCL_1T68' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b9a797dc-91ba-4592-bd06-967f5b38124d' + "SK-MEL-41": + meaning: 'rrid:CVCL_6038' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae3724e-ba3b-4787-b81e-d62d434a3ac9' + "SK-MEL-410": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_1T69' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5f60fa1a-e9a7-4e49-a760-d2906ba17851' + "SK-MEL-411": + meaning: 'rrid:CVCL_1T70' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cd4f5e0-e110-40ce-98c9-422fda40866e' + "SK-MEL-412Parotid": + meaning: 'rrid:CVCL_1T71' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=159262e3-0f60-4af6-95ff-a3696aa6db9e' + "SK-MEL-413-2": + meaning: 'rrid:CVCL_1T72' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=413969a1-e4c2-4a17-84de-5925d1209ed6' + "SK-MEL-423A": + meaning: 'rrid:CVCL_1T73' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0ba04cec-c260-462c-b8ce-75536ba04307' + "SK-MEL-423B": + meaning: 'rrid:CVCL_1T74' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6954af4e-0907-460b-ace8-6f807dc897ea' + "SK-MEL-426": + meaning: 'rrid:CVCL_1T75' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20deb6a8-c59e-4f29-8ee8-cd9828191916' + "SK-MEL-427": + meaning: 'rrid:CVCL_1T76' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13a298c0-38d6-4945-9afb-a7c3bb11509d' + "SK-MEL-428": + meaning: 'rrid:CVCL_1T77' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d34fb6f1-ec5c-440e-97e9-276088635d67' + "SK-MEL-430": + meaning: 'rrid:CVCL_1T78' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=17aba291-d856-4625-aad0-077514b14d40' + "SK-MEL-431": + meaning: 'rrid:CVCL_1T79' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f26dd6bb-0195-4571-98e2-23ec963c86ec' + "SK-MEL-432": + meaning: 'rrid:CVCL_1T80' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913629f6-cace-496b-acb8-03c97e4ace11' + "SK-MEL-435": + meaning: 'rrid:CVCL_1T81' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e528ff6d-23e4-487b-9338-839d2c564a11' + "SK-MEL-439": + meaning: 'rrid:CVCL_1T82' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd531418-d7a3-456f-8473-1e9fd37ed3a5' + "SK-MEL-441": + meaning: 'rrid:CVCL_1T83' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c4b5d552-0eea-4ff6-b127-6d9a691b5600' + "SK-MEL-444": + meaning: 'rrid:CVCL_1T84' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13274e2e-62c6-49ec-92b5-78cafa4cfc73' + "SK-MEL-445": + meaning: 'rrid:CVCL_1T85' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=141f4221-e03d-4b75-a3da-ff8efb3aed02' + "SK-MEL-446": + meaning: 'rrid:CVCL_1T86' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=41aea55a-717a-4460-8593-8b55e90937e6' + "SK-MEL-447": + meaning: 'rrid:CVCL_1T87' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878e80a7-4f50-4a23-a1e6-155d988962a5' + "SK-MEL-451": + meaning: 'rrid:CVCL_1T88' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=20eba743-3053-4e3c-97fc-10a53023430b' + "SK-MEL-452": + meaning: 'rrid:CVCL_1T89' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=042e2889-f4e3-4a3a-85d3-cfa860369bff' + "SK-MEL-455": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_1T90' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d77460a-3139-4299-a912-04a4b479ab44' + "SK-MEL-457": + meaning: 'rrid:CVCL_1T91' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc15a768-cae1-4dc4-ae2e-d861db250ff9' + "SK-MEL-459": + meaning: 'rrid:CVCL_1T92' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7cae97f-787c-49aa-9e78-a487e3e3547b' + "SK-MEL-462": + meaning: 'rrid:CVCL_1T93' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3b36f15b-02d6-47c8-987a-09ccbc9b6e35' + "SK-MEL-464A": + meaning: 'rrid:CVCL_1T94' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0e8f539b-8704-47c8-a4c4-7402602d0445' + "SK-MEL-464B": + meaning: 'rrid:CVCL_1T95' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7440661f-af81-486a-9687-cf6a72d6fd82' + "SK-MEL-479": + meaning: 'rrid:CVCL_1T96' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9612b172-8d91-4524-aa18-7cbe903c7f1b' + "SK-MEL-481": + meaning: 'rrid:CVCL_1T97' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ed77fdc9-b80b-4817-8f86-a01fa5b141cc' + "SK-MEL-483": + meaning: 'rrid:CVCL_1T98' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8f27d0-385b-4dc1-82e8-60a456eff3b2' + "SK-MEL-495": + meaning: 'rrid:CVCL_1T99' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6fa9c1a3-1945-45b1-a9f1-9edb3afd569c' + "SK-MEL-498": + meaning: 'rrid:CVCL_1U00' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce4f80b9-50a2-400c-bd0f-1a1df82931b7' + "SK-MEL-506": + meaning: 'rrid:CVCL_1U01' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=78d23c04-59b6-4532-910a-40cbf8b4d702' + "SK-MEL-507": + meaning: 'rrid:CVCL_1U02' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee56490c-9c27-4952-b001-230e572cb108' + "SK-MEL-509": + meaning: 'rrid:CVCL_1U03' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b1e0094a-ce3a-4505-8d4d-426adf6ec84e' + "SK-MEL-513": + meaning: 'rrid:CVCL_1U04' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=29590580-da13-41b2-a8d3-bd1a2b198f28' + "SK-MEL-524": + meaning: 'rrid:CVCL_1U05' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1eeb831e-3fd4-4d88-9384-717b7dcc20d8' + "SK-MEL-529": + meaning: 'rrid:CVCL_1U06' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ccd7e8d-f5b2-4e2b-8f21-8b982d8921d6' + "SK-MEL-534": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_1U07' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7515b60c-dc11-4786-b3aa-fd7a8f5397f1' + "SK-MEL-538": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=24576830).' + meaning: 'rrid:CVCL_1U08' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e2a83d29-7938-4a12-ae21-75b4dbbff7ac' + "SK-MEL-64": + meaning: 'rrid:CVCL_6048' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=053cef50-1dee-46f8-b4a9-2881742ff06d' + "SK-MEL-7": + meaning: 'rrid:CVCL_D854' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3be7fe60-bbb4-497b-9cd1-8b5c7005cb92' + "SK-MEL-73": + meaning: 'rrid:CVCL_6053' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a342ec-bfa3-490e-b8b2-51141b588def' + "SK-MEL-75": + meaning: 'rrid:CVCL_6054' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46c046c5-20ac-4a51-a73a-758f0a881b2a' + "SK-MEL-90": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=21725359, PubMed=24576830).' + meaning: 'rrid:CVCL_6227' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7f3abe8b-5048-4e2f-beae-63a437218761' diff --git a/modules/Sample/generated/cellline_Musmusculus.yaml b/modules/Sample/generated/cellline_Musmusculus.yaml new file mode 100644 index 00000000..b6cc5b5b --- /dev/null +++ b/modules/Sample/generated/cellline_Musmusculus.yaml @@ -0,0 +1,27 @@ +# Auto-generated species-filtered model system enum +# System type: cell line +# Species: Mus musculus +# Count: 5 entries + +enums: + CelllineMusmusculusEnum: + permissible_values: + "BayGenomics ES cell line XF344": + description: 'Nf1 knockout cell' + meaning: 'rrid:CVCL_PR85' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=60633d59-0230-47c3-9d40-08b0ae194b6d' + "KOMP ES cell line Nf1": + description: 'JM8.F6 derived from C57BL/6N' + meaning: 'rrid:MMRRC_059313-UCD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d596eb56-33b0-4dcc-b7e4-0922a93c4134' + "KOMP ES cell line Nf1": + description: 'JM8.F6 derived from C57BL/6N' + meaning: 'rrid:MMRRC_059314-UCD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e0a4cc28-022b-48ed-acf5-28ee38eb20bd' + "Nf1Arg681*/Arg681* MEFs": + description: '[From GFF:] Nf1Arg681*/Arg681* MEFs' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47f50ef0-8d59-430d-9d05-7df1a4f41c3b' + "SIGTR ES cell line AA0320": + description: 'High throughput gene trapping was performed by inserting a gene trap vector containing a splice-acceptor sequence upstream of a reporter gene, β-geo (a fusion of β-galactosidase and neomycin phosphotr...' + meaning: 'rrid:MMRRC_025689-UCD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8a75443-a92f-45f7-9290-0669405e2e9c' diff --git a/modules/Sample/generated/cellline_Unknown.yaml b/modules/Sample/generated/cellline_Unknown.yaml new file mode 100644 index 00000000..59205438 --- /dev/null +++ b/modules/Sample/generated/cellline_Unknown.yaml @@ -0,0 +1,1329 @@ +# Auto-generated species-filtered model system enum +# System type: cell line +# Species: Unknown +# Count: 365 entries + +enums: + CelllineUnknownEnum: + permissible_values: + "10/9CRC1": + meaning: 'rrid:CVCL_8478' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25c617df-ff54-4ba5-b293-d9fcc9be39ce' + "10CM": + description: 'Mutation of NF1, p.Arg440Ter (c.1318C>T), Unspecified zygosity (PubMed=26744134). Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26744134).' + meaning: 'rrid:CVCL_VJ83' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=423cc0f3-8a43-4e10-a9a4-d529aa78f022' + "1507.2": + meaning: 'rrid:CVCL_1Y71' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4304050f-f24a-45b9-9025-8e3e88d0b377' + "2-004": + description: 'Patient-derived cell line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b44907f-47e9-470f-918e-03e55cc9eff9' + "28cNF": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (i28NF).' + meaning: 'rrid:CVCL_B9V9' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a466cdc-5eaa-45a5-87b1-ba9cac6d7d21' + "2XSB": + meaning: 'rrid:CVCL_A7NI' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f4e4596-0c7d-4d41-b9ff-73ecebd30263' + "3PNF_FiPSsv_PM_2": + description: 'Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank.' + meaning: 'rrid:CVCL_UN11' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7deb7765-38aa-4d8a-a3cb-bd4aefeb3a86' + "3PNF_SiPSsv_MM_11": + description: 'Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank.' + meaning: 'rrid:CVCL_UN12' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cc872fc-6a95-4722-a598-bf60bb124b82' + "4/30PRR": + meaning: 'rrid:CVCL_8480' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0aed5bf6-d5e2-4a6d-ac3b-a51b5e8bbb8b' + "5PNF_TDiPSsv_MM_4": + description: 'Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank.' + meaning: 'rrid:CVCL_UN13' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db6b3d0d-ee80-49ab-bb51-5672448e580b' + "5PNF_TDiPSsv_PM_6": + description: 'Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank.' + meaning: 'rrid:CVCL_UN14' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ebe9be8-88df-4598-bd25-510de550ca5e' + "6PNF_SiPSrv_PM_2": + description: 'Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank.' + meaning: 'rrid:CVCL_UN15' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e4deb9a8-7929-44f2-974d-375771b8c681' + "7PNF_SiPSrv_PM_12": + description: 'Cutaneous neurofibroma-derived iPSC banked in the Barcelona node of the Spanish National Cell Bank.' + meaning: 'rrid:CVCL_UN16' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95997768-950e-4c8d-93bb-e6ed370e503f' + "862L": + meaning: 'rrid:CVCL_8477' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6faf7e00-d770-4527-9384-539f6db31977' + "9/3L": + meaning: 'rrid:CVCL_8479' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c98ce5c-5cf1-4829-943d-5142073583d8' + "90-8": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_1B47' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f404e70-2acf-4877-bcd5-6da81d9fa41e' + "A68": + description: 'From a surgically excised pNF specimen of a 51-year-old female with NF1' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=328fd785-453d-4a09-be93-b7da67d9d33e' + "AMC-106": + meaning: 'rrid:CVCL_9477' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf77b1e3-93be-4b4e-bc34-85d8b9d06a81' + "Abcam A-549 NF1 KO": + description: 'Mutation of KRAS, p.Gly12Ser (c.34G>A), Homozygous (from parent cell line).' + meaning: 'rrid:CVCL_B9NJ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d605ae2e-969a-4956-bac5-5e36654d7b41' + "Abcam HCT 116 NF1 KO": + description: 'Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (from parent cell line).' + meaning: 'rrid:CVCL_B8LD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f5ec9375-0564-414a-94ad-86d5083b440f' + "Abcam HeLa NF1 KO": + description: 'Nf1 knockout cell' + meaning: 'rrid:CVCL_B1YJ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b26e0c8b-689f-4018-bf27-e2d3a522e039' + "Abcam U-87MG SNCA KO": + description: 'Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line).' + meaning: 'rrid:CVCL_C0BJ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ac5f5d4a-95f7-4e5c-9db1-d13fbc9748a7' + "AsPC-1": + description: '2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=15367885, PubMed=21607521, Cosmic...' + meaning: 'rrid:CVCL_0152' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5bbfd278-a1aa-4279-b648-94efe9e1f242' + "BJFF.6": + description: 'iPSCs created with foreskin fibroblasts.' + meaning: 'rrid:CVCL_VU02' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8a213a9d-392b-4746-8f59-c12f753d9217' + "BTSC 232": + description: 'Human patient-derived brain tumor stem cell lines (BTSCs)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4d9d286-d169-41d0-8dc8-45bc92984aaf' + "BTSC 233": + description: 'Human patient-derived brain tumor stem cell lines (BTSCs)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b664f320-dd73-4aae-82e7-91c42b48744a' + "BTSC 3021": + description: 'Human patient-derived brain tumor stem cell lines (BTSCs)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f98c4bb5-b168-431a-8642-f769bed673a3' + "BTSC 3047": + description: 'Human patient-derived brain tumor stem cell lines (BTSCs)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=852b8fa5-892d-4353-9d6b-4673396ca999' + "BTSC 349": + description: 'Human patient-derived brain tumor stem cell lines (BTSCs)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ea69fa4e-4393-4ffe-a5a8-f4df59789813' + "BTSC 380": + description: 'Human patient-derived brain tumor stem cell lines (BTSCs)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98790fc2-9cdf-442c-94d2-e6775cfb8ad3' + "CFPAC-1": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=11169959, PubMed=11787853, PubMed=15367885, Cosmic-CLP).' + meaning: 'rrid:CVCL_1119' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6f287de-eadb-4020-be7a-5b761172fec6' + "CML-6M": + description: 'Pigmented. Mutation of NF1, p.Pro1599fs (c.4795delCinsTT), Heterozygous (PubMed=31175136).' + meaning: 'rrid:CVCL_0D24' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=acd954de-1f36-41ad-8ce0-ac738aa840ba' + "COLO 668": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1128' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2a57bc0e-51ee-4a44-a872-2ed8ab56f4c6' + "COR-L23": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1139' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6928d53-c913-4078-8354-4a5de3d5c824' + "CPTC-NF1-1": + meaning: 'rrid:CVCL_C2NU' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65d07476-2469-4679-85b2-e2ca67f3b01b' + "CPTC-NF1-2": + meaning: 'rrid:CVCL_C2NV' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f410431d-7571-4302-8870-eb115b71d0ce' + "CPTC-NF1-3": + meaning: 'rrid:CVCL_C2NW' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42257ac4-1950-4541-9bee-b9a965e2fa86' + "CTV-1": + description: 'Mutation of NF1, p.Gly1532Arg (c.4594G>A), Heterozygous (PubMed=22675565, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1150' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37cbf7b9-f74c-4407-8541-86c17e394c5d' + "Calu-1": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=12794755, DepMap).' + meaning: 'rrid:CVCL_0608' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=055e78dc-b3d2-416b-a7f1-ac4de9d9ec2b' + "Capan-1": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=8026879, PubMed=8426738, PubMed=15367885, PubMed=21750719, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0237' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=efe31e45-2075-4b41-a06f-a1d5935622fa' + "Capan-2": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=7961102, PubMed=8026879, PubMed=8426738, PubMed=11169959, PubMed=15367885, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0026' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a32eaaa-e7cf-45a2-ae52-528a09eea541' + "D-566MG": + description: 'Mutation of NF1, p.Ile941Serfs*13 (c.2820delC), Heterozygous (Cosmic-CLP).' + meaning: 'rrid:CVCL_1166' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc7c0fee-8a89-49a2-b58c-eff50448006d' + "DAN-G": + description: '2 alleles of G12V mutation in KRAS gene. Established from a xenograft produced by implantation of cells from the tumor of a patient with cancer of the pancreas in a nude mouse (CLS). Mutation of KRAS,...' + meaning: 'rrid:CVCL_0243' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=99359d65-6e01-410d-be59-217aa0bfb9c9' + "DD2345": + description: 'An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line' + meaning: 'rrid:CVCL_9J79' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2e792f78-55b0-4091-9f86-6b78abd920bb' + "Dh5 alpha": + description: '[From GFF:] Dh5 alpha' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=68977077-e0a3-40df-92ab-d62285edd23c' + "Dhh-Cre; NF1Arg681*/flox Schwann Cells": + description: '[From GFF:] Dhh-Cre; NF1Arg681*/flox Schwann Cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ae5651a-818f-4732-8045-17bea2555056' + "FMS-1": + meaning: 'rrid:CVCL_IS33' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b14a6ae1-829c-4ae3-9149-9fcf6cc6c57d' + "FTC-133": + description: 'Has a near-homozygous genome (NHG). Mutation of NF1, p.Cys167Ter (c.501T>A), Homozygous (PubMed=30737244).' + meaning: 'rrid:CVCL_1219' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a630172-cf98-41c1-ae06-c436900fb513' + "FU-SFT8710": + meaning: 'rrid:CVCL_ZE77' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b96c1fa0-5284-424a-b29e-338db3c8b292' + "GI-ME-N": + description: 'Gene deletion, NF1, Heterozygous (PubMed=20655465). Mutation of NF1, Microdeletion, Heterozygous (PubMed=20655465).' + meaning: 'rrid:CVCL_1232' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe5b49ff-6d77-4de3-adc3-0fc97fd076e4' + "GI-ME-NrCDDP500": + description: 'Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line).' + meaning: 'rrid:CVCL_RS22' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=73b8caeb-cc91-4d81-b076-25d611949807' + "GI-ME-NrDOX5": + description: 'Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line).' + meaning: 'rrid:CVCL_RS07' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a03250ca-0914-4318-b5c6-5b5a86ca1965' + "GI-ME-NrVCR14": + description: 'Gene deletion, NF1, Heterozygous (from parent cell line). Mutation of NF1, Microdeletion, Heterozygous (from parent cell line).' + meaning: 'rrid:CVCL_RR32' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25fa8030-970e-48ec-8e22-55e23a747164' + "GP2d": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap).' + meaning: 'rrid:CVCL_2450' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c62fab0b-8aa2-4732-9ffb-7d80b8b425ab' + "GWH04": + description: 'Mutation of NF1, p.Ter640Argext (c.1918T>C), Unspecified zygosity (PubMed=36169178).' + meaning: 'rrid:CVCL_C0W3' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=298cca5d-cc3d-4215-968e-8ac5f890ae22' + "HAP1 NF1 (-) 1": + meaning: 'rrid:CVCL_TA51' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=300695f7-5d65-413f-8f6c-290c4b09f710' + "HAP1 NF1 (-) 2": + meaning: 'rrid:CVCL_TA52' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72511c95-eaa4-403d-914e-2658e2cabd51' + "HAP1 NF1 (-) 3": + meaning: 'rrid:CVCL_TA53' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1f58179b-18b4-48ee-b3b0-fe8536815838' + "HAP1 NF1 (-) 4": + meaning: 'rrid:CVCL_TA54' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6d95003f-3800-4d3a-b2fb-a5fbf7adae3c' + "HBE135-E6E7": + description: '[From ATCC:] The HBE135-E6E7 cell line was derived from normal bronchial epithelium taken from a man undergoing lobectomy for squamous cell carcinoma. Cells from the primary explant in their first pas...' + meaning: 'rrid:CVCL_3695' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0a1a3741-0337-4067-95ab-fb0dc9562d66' + "HCT 116": + description: '1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0291' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=077ce9fd-c141-4baa-b8ac-80aa2922a041' + "HCT 15": + description: '1 alleles of G13D mutation in KRAS gene' + meaning: 'rrid:CVCL_0292' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dc12b0e-f9e9-4486-a923-720a8a36bb4e' + "HPAF-II": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11787853, PubMed=12068308, PubMed=15367885, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0313' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fd37b60c-e8f7-451a-87e2-20792451c6fe' + "HPS1312": + meaning: 'rrid:CVCL_UN64' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e85ecf49-5767-41bd-86f8-2c24c3565a14' + "HPS1313": + meaning: 'rrid:CVCL_A3UD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f0bb3a66-ad46-4458-bb2a-eb01d5860aaf' + "HPS1314": + meaning: 'rrid:CVCL_A3UE' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d2b29409-3d0c-4ff6-a1d4-eb1ea8e856bb' + "HPS1315": + meaning: 'rrid:CVCL_A3UF' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2c7033c-1cc1-437c-8dd5-699ce1c52c31' + "HPS1316": + meaning: 'rrid:CVCL_A3UG' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=88c655aa-2117-4a84-a15f-ddfa3abcf0e9' + "HPS1317": + meaning: 'rrid:CVCL_A3UH' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d1529d1-682a-493f-accf-c498a8a06f29' + "HPS2250": + meaning: 'rrid:CVCL_UP04' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=85718709-ca03-493c-be51-f63650440435' + "HPS2251": + meaning: 'rrid:CVCL_A3RL' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d29aaa05-2dae-4f67-b8b1-742d182a6b83' + "HPS2252": + meaning: 'rrid:CVCL_A3RM' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3d4806ba-76ec-452c-881b-7a7b48828790' + "HPS2253": + meaning: 'rrid:CVCL_A3RN' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b5a2e06e-fd9e-4586-9ab9-4a950815d4c1' + "HPS2254": + meaning: 'rrid:CVCL_A3RP' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50a687df-afc8-493f-8f5a-a40eceb32946' + "HPS2255": + meaning: 'rrid:CVCL_A3RQ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25a6d925-3be3-42d1-8373-e7f8c5fe85aa' + "HS-PSS": + description: "A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be." + meaning: 'rrid:CVCL_8717' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd49d4e2-575e-4e89-8317-cff02db4882c' + "HS-Sch-2": + description: "A cell line previously identifed as MPNST, though recent 'omic analysis suggests that it might not be." + meaning: 'rrid:CVCL_8718' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=19bba596-fc3d-479b-9675-afa369b44dee' + "HS53T": + description: 'human NF1-associated MPNST derived cell line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=86dcdce8-8416-4157-a31e-04c6edd3ca65' + "HSC1λ": + description: 'human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0193c87-8813-4841-92e7-ee5095bd94fe' + "HTh74": + description: 'Established from a tumor implanted into a nude mice. Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (PubMed=30737244).' + meaning: 'rrid:CVCL_6288' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ace6c78c-3ea6-426d-83b3-1ceeecd74db3' + "HTh74 clone 7": + description: 'Mutation of NF1, p.Leu732fs (c.2195_2202delTGCCCAAC), Homozygous (from parent cell line).' + meaning: 'rrid:CVCL_AT82' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d86c2e88-3de9-4c0f-9cb5-de2921b8207f' + "HeLa SilenciX NF1": + description: 'HeLa cervical cancer cells with stable (EBV-based siRNA) knockdown of the NF1 gene.' + meaning: 'rrid:CVCL_KT82' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2549e536-b033-43e4-acf6-501499b6e498' + "HuP-T4": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1300' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1e7bf984-5c1f-463e-89e1-b5d9b552aef5' + "JH-2-002": + description: 'Collected during surgical resection from patients with NF1-MPNST' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1bc84ef2-208f-4f0e-8045-6be47fd968de' + "JH-2-009": + description: 'Collected during surgical resection from patients with NF1-MPNST' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0bc812b4-f2af-40c4-8245-1070ab12f627' + "JH-2-031": + description: 'Collected during surgical resection from patients with NF1-MPNST' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4241b7ff-c08e-4c6d-b2c1-9de9ac91f72b' + "KCL024": + description: 'Human embryonic stem cell line derived from an embryo with an NF1 mutation.' + meaning: 'rrid:CVCL_A257' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5fdcfb8-24e7-46fa-9f48-bcbae8a90b7a' + "KCL025": + description: 'Human embryonic stem cell line derived from an embryo with an NF1 mutation.' + meaning: 'rrid:CVCL_A258' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=18ba4c2e-e8d5-4032-a6ab-d0fca3f0f984' + "KP-3": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=21607521, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_3005' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4a550816-e561-4d4b-a25c-995ea23b8a41' + "LCLC-97TM1": + description: '2 alleles of G12V mutation in KRAS gene' + meaning: 'rrid:CVCL_1376' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a7fe3fbf-d242-40b6-9d33-c19e8e0057e0' + "LS180": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=20570890, PubMed=24755471, ATCC).' + meaning: 'rrid:CVCL_0397' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=54b8989a-e04f-47ac-bc0c-a5871b943228' + "LS513": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471).' + meaning: 'rrid:CVCL_1386' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=40f95c38-f30f-4ce8-8a92-97baecbc53fc' + "Lis42_NF1_1N": + description: 'Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1.' + meaning: 'rrid:CVCL_Y368' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cd38ffda-2db1-47f0-af6f-8de572e06037' + "Lis47_NF1_2N": + description: 'Human embryonic stem cell line derived from an embryo with neurofibromatosis type 1.' + meaning: 'rrid:CVCL_Y373' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0ca95f1-a3d9-4641-b47d-84346d9ec04a' + "LoVo": + description: '1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0399' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5ce9c8-7f59-43b0-ac57-3a883d75dff3' + "Lu-65": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1392' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6365e6d0-eefd-4778-9e0f-d8c549838ff2' + "Lu-99": + description: '1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap).' + meaning: 'rrid:CVCL_3015' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=31448c47-8e6d-412c-917a-9f92c53ad687' + "MCRIi020-A": + description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne..." + meaning: 'rrid:CVCL_A1MD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d941428a-ebcb-4acf-90ae-107d7cfc52d1' + "MCRIi021-A": + description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne..." + meaning: 'rrid:CVCL_A1ME' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5a676545-f9b5-4fdb-bf0f-3b68dfdb58b8' + "MCRIi022-A": + description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne..." + meaning: 'rrid:CVCL_A1MF' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb564630-535a-4d14-8a07-f2b4e64f4926' + "MCRIi023-A": + description: "Human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) from individual with neurofibromatosis type (NF1). From: Murdoch Children's Research Institute, Melbourne..." + meaning: 'rrid:CVCL_A1MG' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8295296a-e1d7-4c9f-beaa-2ac02d09c149' + "MH/Nike": + description: 'Mutation of NF1, p.Ala2176fs (c.6525delG), Homozygous (PubMed=31175136).' + meaning: 'rrid:CVCL_DN29' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9cb659ee-8d25-4016-a2a5-4c230bfc933e' + "MIA PaCa-2": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=7961102, PubMed=8026879, PubMed=11115575, PubMed=11169959, PubMed=11787853, PubMed=12068308, PubMed=...' + meaning: 'rrid:CVCL_0428' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ee325d43-d215-4610-aa67-011ea95efaab' + "MUG-Mel1": + description: 'Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407).' + meaning: 'rrid:CVCL_VV72' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ce4f191-b7ce-437d-8cef-f6de332040e0' + "MUG-Mel1 clone C8": + description: 'Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407).' + meaning: 'rrid:CVCL_VV73' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=590ebb66-5944-4cf7-accc-23e18d6c3818' + "MUG-Mel1 clone D5": + description: 'Mutation of NF1, p.Lys1745Glu (c.5233A>G), Heterozygous (PubMed=30858407).' + meaning: 'rrid:CVCL_VV74' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=96f2ab08-2c90-4ef9-9d56-1705ee49cecc' + "Mes-9": + meaning: 'rrid:CVCL_H658' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b61a902-c96f-4849-abd3-7631963e1cc5' + "N10": + description: 'N5 and N10 cells lines underwent CRISPR/Cas9 targeting against\xa0NF1' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=de94c5d9-6feb-402f-a0c6-6ac3389907c6' + "N206": + meaning: 'rrid:CVCL_C885' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6cbf7434-7dd5-4ed5-9ca6-77e65e2b4b36' + "NB90-4": + meaning: 'rrid:CVCL_A5PQ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9bacf245-10fb-48b1-ae87-1034bd1259a0' + "NB90-6": + meaning: 'rrid:CVCL_A5PR' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fdfba143-b6fe-494f-ae25-8796009e8090' + "NCI-H1373": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, DepMap).' + meaning: 'rrid:CVCL_1465' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a14754e6-1c26-4224-9ef9-a1abfd1538eb' + "NCI-H1385": + description: '1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (DepMap).' + meaning: 'rrid:CVCL_1466' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=93469888-1234-4f52-b3a7-175423b817cc' + "NCI-H1651": + description: 'Mutation of NF1, p.Arg997fs*15 (c.2990delG), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1484' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c82d4706-1c04-46d2-9d23-6b5a7fc24767' + "NCI-H1792": + description: '1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1495' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d28192f0-d180-40e1-b184-de3fed398e72' + "NCI-H1838": + description: 'Mutation of NF1, p.Asn184fs*17 (c.548_549insA), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1499' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7008ce3-09ef-4150-a793-69bdde435b66' + "NCI-H1944": + description: '1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1508' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e3ae7e3f-d6ae-48d9-8e08-e2625c048642' + "NCI-H2030": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1517' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177c35b5-d859-4bf2-870b-9311ef059159' + "NCI-H2122": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1531' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=12d08160-d127-463a-9e6e-c62347f9e756' + "NCI-H23": + description: '1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=17088437).' + meaning: 'rrid:CVCL_1547' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=95e9ea19-3d84-43a5-b003-347ecec6b1fa' + "NCI-H2444": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1552' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=da179d37-bc2d-4725-8621-f8ec49b917d0' + "NCI-H358": + description: '1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=1311061, PubMed=9649128, PubMed=12068308).' + meaning: 'rrid:CVCL_1559' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cca5b217-ce0b-4c2b-814f-54fefb967475' + "NCI-H441": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, ATCC, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1561' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=665f978b-9fec-4f0b-8921-058a94b84bcd' + "NCI-H647": + description: '2 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Homozygous (PubMed=1311061, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1574' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df53b267-e448-4051-a0d8-1db4da3c5c41' + "NCI-H727": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=1311061, PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1584' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d124e590-59ba-44c6-9c9f-0b0a3c96862c' + "NCI-H747": + description: '1 alleles of G13D mutation in KRAS gene. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1587' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=06004dd0-1122-46cc-b049-8349d9511c64' + "NF1": + description: 'Cell line from an NF1 patient; unclear if derived from tumor or non-tumor tissue.' + meaning: 'rrid:CVCL_JG80' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1a8a362e-e3be-4bc3-be7e-d0a0865b9c31' + "NF1+/- hiPSC-SCPs": + description: 'Collected during surgical resection from patients with NF1-MPNST' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa3052b-d40a-4f73-b12e-b68c472497bb' + "NF1-/- hiPSC-SCPs": + description: 'Collected during surgical resection from patients with NF1-MPNST' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fc7520bc-3deb-43c2-81e9-b71cbf4daa65' + "NF1-R68X Embryonic cells": + description: '[From GFF:] NF1-R68X Embryonic cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=90748442-be62-44f1-899e-804cd5600823' + "NF10.1": + description: 'NF1-deficient MPNST tumor cell line from an NF1 patient.' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2e468b4-b8cf-4473-b5f5-b7f47415d40f' + "NF11.1": + description: 'NF1-deficient MPNST tumor cell line from an NF1 patient.' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dc674458-affb-46a3-8a48-90fe556b44d1' + "NF1C-FiPS-SV4F7": + description: 'NF1(-/-) iPSC line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=00f8dcc6-a2b2-4fc2-a327-e87367bffa21' + "NF1‐iN": + description: 'fibroblasts cell lines from a NF1 patient' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e608c5ee-fd65-4a08-9c89-9bf16f83956f' + "NFS-1": + meaning: 'rrid:CVCL_1Y69' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e6866e8-c67d-4650-a0a3-a10a5a8bdb49' + "NGP": + meaning: 'rrid:CVCL_2141' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd026e3f-c345-4e67-8d79-31c1cd295a25' + "NMB": + meaning: 'rrid:CVCL_2143' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=49286dfd-632c-4f62-834f-d1441e05fde5' + "NMS-2": + description: 'human MPNST cell lines' + meaning: 'rrid:CVCL_4662' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=83512f26-8cc3-48db-8f66-1b490a943eb1' + "NMS-2PC": + meaning: 'rrid:CVCL_L810' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=50b33e18-9c4a-470c-b982-7f612be9a79b' + "NMS-PC": + description: 'human MPNST cell lines' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c7fb76f-0aae-4e0c-9a69-f50f6a5c5ebb' + "NZM022": + description: 'Mutation of NF1, p.Arg1362Ter (c.4084C>T), Unspecified zygosity (PubMed=32567790).' + meaning: 'rrid:CVCL_D825' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=14569691-bdb1-4cd7-ae1c-943f100e93ff' + "NZM041": + description: 'Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790).' + meaning: 'rrid:CVCL_S426' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7d017560-faf4-4230-a9cb-b9e742b158c4' + "NZM047": + description: 'Mutation of NF1, p.Asn1112fs, Unspecified zygosity (PubMed=32567790). Mutation of NF1, p.Gln2582Ter (c.7744C>T), Unspecified zygosity (PubMed=32567790).' + meaning: 'rrid:CVCL_S424' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=416e4ab2-7916-4853-9cf8-4ff76aec072a' + "NZM072": + description: 'Mutation of NF1, p.Arg416Ter (c.1246C>T), Unspecified zygosity (PubMed=32567790).' + meaning: 'rrid:CVCL_0D36' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fb8aed26-e95a-4b7d-b4fb-d4b9f1847c9c' + "NZM077": + description: 'Mutation of NF1, p.Pro1323Ser (c.3967C>T), Unspecified zygosity (PubMed=32567790).' + meaning: 'rrid:CVCL_0D40' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0b08c4c-2662-47b2-9eb0-306a8871f92e' + "NZM087": + description: 'Mutation of NF1, p.His1170Tyr, Unspecified zygosity (PubMed=32567790).' + meaning: 'rrid:CVCL_0D47' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84d5c1ae-b82b-4b80-ab7a-3884c8efafda' + "Nf1-/- Epithelial lung cells": + description: '[From GFF:] Nf1-/- Epithelial lung cells, derived from HBE135-E6E7 epithelial lung cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=779714c8-f522-4355-a502-d5d2e6e09afa' + "Nf1-/- skin-derived precursor cells": + description: '[From GFF:] Nf1-/- skin-derived precursor cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=15c3bd82-9791-4a53-b6f7-4d23b882a285' + "Nf1Arg681*/+ ES": + description: '[From GFF:] Nf1Arg681*/+ ES' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ff97eee-5c1a-4439-9df6-d1715cbdd189' + "Nf1Arg681*/Arg681* ES": + description: '[From GFF:] Nf1Arg681*/Arg681* ES' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=70c1e3f6-751f-49e4-aa47-e3bea4aeac43' + "OSW": + description: 'Mutation of NF1, p.Asn58fs (c.167delA), Homozygous (PubMed=31175136).' + meaning: 'rrid:CVCL_0B19' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a62af66-384d-419b-b8ac-f4d381b85942' + "PEO4": + description: 'Mutation,\xa0NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (CelloPub=CLPUB00667, DepMap).' + meaning: 'rrid:CVCL_2690' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb0770ce-7733-41e5-8ca3-d1abfbe44a31' + "PEO4-iPSC-OSKM-03": + description: 'Mutation,\xa0NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line).' + meaning: 'rrid:CVCL_B7JI' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7126593e-4b96-40a5-9ff4-d41b81fbba4c' + "PEO4-iPSC-OSKM-05": + description: 'Mutation,\xa0NF1, p.Arg160Trp (c.478A>T). Mutation of NF1, p.Arg160Trp (c.478A>T), Homozygous (from parent cell line).' + meaning: 'rrid:CVCL_B7JJ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f103987e-5196-440e-a6ba-53d39305c714' + "PK-1": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap).' + meaning: 'rrid:CVCL_4717' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53f296e1-638f-44af-8a6f-e9dd601586b0' + "PK-45H": + description: '2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (DepMap).' + meaning: 'rrid:CVCL_6748' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e18db26-a0c8-4418-8c64-a73d3fa7e8af' + "PK-59": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=11115575, PubMed=22490663, DepMap).' + meaning: 'rrid:CVCL_4897' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9f1d08c5-73a8-47e5-b113-031c6a55316d' + "PNET-1": + meaning: 'rrid:CVCL_A5PP' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=65a74b6e-bede-4228-a43d-3939f2c6311a' + "PNET-2": + meaning: 'rrid:CVCL_4432' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=45cf8733-b0c2-433e-b5fc-abd3a0748b79' + "PaTu 8902": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1845' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ead740e0-7ced-4d3c-b411-207cd8f7ae74' + "Panc 02.03": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1633' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21237832-d6ba-422e-80ec-36a3ae6d7c7a' + "Panc 03.27": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (ATCC, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1635' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2acf94e6-185b-4717-8f04-71ac8b6d62e3' + "Panc 04.03": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1636' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=177e4c5c-f9dd-4695-a3ca-fb9205aae724' + "Panc 08.13": + description: '2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=9612602, ATCC).' + meaning: 'rrid:CVCL_1638' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d861eabe-95d4-47d7-bbb9-be13f7db26f6' + "Panc 10.05": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=9612602, ATCC, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1639' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf2cfa90-a8cd-4ae4-ad5d-2ab86eddd313' + "QGP-1": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=21607521, PubMed=29444910, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_3143' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b3b46e6a-030c-4f5e-8d86-d0f540d31edb' + "QQ0588": + description: 'An Epstein-Barr virus (EBV) transformed lymphoblastoid cell line' + meaning: 'rrid:CVCL_8Y66' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=53c871d3-6f75-49a6-aa73-42d0ead2298b' + "RCM-1": + description: '2 alleles of G12V mutation in KRAS gene. Mutation,\xa0KRAS, p.Gly12Val (c.35G>T), Homozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1648' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c003a385-2de1-4ee8-a2d3-212bb746dac9' + "RERF-LC-Ad2": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (DepMap).' + meaning: 'rrid:CVCL_1652' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6cb07c1-218d-4762-90d9-4de228447635' + "RG-137": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: 'rrid:CVCL_B564' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9b9d9f06-2918-490e-a783-1655c757d922' + "RG-138": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: 'rrid:CVCL_B565' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e6e0a7ed-94f6-42e1-9700-6cafcb00f426' + "RG-139": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: 'rrid:CVCL_B566' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1dc0e42-68f8-4650-89ac-37a6acdeb10e' + "RG-140": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: 'rrid:CVCL_B567' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2fe9632c-b6db-443f-a512-4b2523a470e0' + "RG-141": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Trp1831Ter (c.5492G>A) (p.Trp1810Ter, c.5429G>A), Unspecified zygosity (PubMed=15705304).' + meaning: 'rrid:CVCL_B568' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aba67450-594d-422b-a7fe-6c69a882b859' + "RG-235": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA.' + meaning: 'rrid:CVCL_B653' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=978d317f-f1d6-4039-a2f5-f0787adf589a' + "RG-315": + description: 'Embryonic stem cell. From: Reproductive Genetics Institute, Chicago, USA., Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T); Heterozygous (ISCR).' + meaning: 'rrid:CVCL_B721' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0360411b-59dd-457a-ab6f-38a9182c425e' + "S462": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_1Y70' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b2fb9f7e-ea11-404f-8c0c-c9dc36367f2d' + "S462.TY": + description: 'MPNST tumor cell line from an NF1 patient, created by passaging S462 cell line in mice as xenografts.' + meaning: 'rrid:CVCL_JK02' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d6a101aa-9ca8-4191-9b43-eddf327ea48b' + "S462s": + description: 'Human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4c655750-7b47-4cd1-bc5d-2bc6246f5e26' + "S462sp": + description: 'MPNST-derived cell line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8ab6c976-dbd3-4616-9911-23f4981fa5c5' + "S520": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_AX35' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c0a60dec-8ead-43c5-abc2-b06b89dd20cd' + "SHG-140": + description: 'Mutation of NF1, p.Arg1968Ter (c.5902C>T) (p.Arg1947Ter, c.5839C>T), Homozygous (PubMed=33391433).' + meaning: 'rrid:CVCL_A0XC' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=aaa66c45-c7b1-4a85-bfe9-79bb0a1334a7' + "SHP-77": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1693' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b177ff32-b33c-4327-8862-e5b23994b502' + "SJNB-1": + meaning: 'rrid:CVCL_8812' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e1d0a02-22cc-489a-851c-c7b9955a6270' + "SJNB-10": + description: 'Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465).' + meaning: 'rrid:CVCL_1441' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d7bcdcae-52d3-4bc5-af24-243483588ee5' + "SJNB-12": + meaning: 'rrid:CVCL_1442' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a6bcc8ec-3169-4e4f-afbb-fbca2658007c' + "SJNB-13": + meaning: 'rrid:CVCL_1443' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1785a08d-ce83-45f6-bba8-68f4b0d3514c' + "SJNB-14": + meaning: 'rrid:CVCL_1444' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ae35c72c-7fd9-463b-9b0d-fb4670ccf05e' + "SJNB-16": + meaning: 'rrid:CVCL_8815' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ce47dba5-1303-4253-af99-3e16cc14a341' + "SJNB-19": + meaning: 'rrid:CVCL_8817' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d45b694e-00fc-481a-96d5-c081941d14f5' + "SJNB-2": + meaning: 'rrid:CVCL_8818' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=965771a4-c863-4e89-a9db-d160d1e4c5e5' + "SJNB-3": + meaning: 'rrid:CVCL_8820' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c87d24ac-439e-404a-9a43-6110c497599e' + "SJNB-4": + meaning: 'rrid:CVCL_8821' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1d2aa58f-2aaa-44ca-96e0-e37231052451' + "SJNB-5": + meaning: 'rrid:CVCL_8822' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9634dff-4e4e-4cd9-bfe9-3d23e7d40583' + "SJNB-6": + meaning: 'rrid:CVCL_8823' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9c45c5d-8707-437e-ab75-a8135e95b45d' + "SJNB-7": + meaning: 'rrid:CVCL_8824' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e6aae84-e57c-4c1d-9ce7-24a03026b435' + "SJNB-8": + meaning: 'rrid:CVCL_8825' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=742d8193-6e25-4f0f-adc7-5dc881727673' + "SJNB-9": + meaning: 'rrid:CVCL_8826' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abfc2e7c-0d28-422f-9973-74b5fb66b402' + "SK-CO-1": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0626' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5e7d6716-540f-4206-a32e-4b7ca4b4c53e' + "SK-LU-1": + description: '1 alleles of G12D mutation in KRAS gene. Cell line positive for alternative lengthening of telomeres (ALT+). Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=1855224, PubMed=12068308, PubM...' + meaning: 'rrid:CVCL_0629' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=903d9857-0c45-4817-a8d6-b43490a3fbcb' + "SK-N-AS": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1700' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cebfdef3-2323-48d9-bfbb-aa704338eabe' + "SK-N-FI": + description: 'Mutation of NF1, Partial deletion, Homozygous (PubMed=20655465).' + meaning: 'rrid:CVCL_1702' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1c53f612-f254-487d-a545-186fd4e2b856' + "SK-N-SH": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0531' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb1b960d-bfd7-48d2-b467-c7faf52b4b3a' + "SMBCi003-A": + description: 'Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297).' + meaning: 'rrid:CVCL_YC55' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=25e3f6d6-c625-43fc-a1ed-c267bba685f1' + "SMBCi003-B": + description: 'Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (PubMed=32554297).' + meaning: 'rrid:CVCL_YC56' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0361ea84-13bb-4f90-8f24-bbd01a81801e' + "SMBCi003-C": + description: 'Mutation of NF1, p.Val166Leufs*7 (c.496_497delGT), Heterozygous (from autologous cell lines SMBCi003-A and SMBCi003-B).' + meaning: 'rrid:CVCL_YC57' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08a0f6ee-700b-4df3-94cd-cc414214ca99' + "SNU-407": + description: '1 alleles of G12D mutation in KRAS gene, KRAS codon 12 GGT->GAT. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (PubMed=10362137, Cosmic-CLP).' + meaning: 'rrid:CVCL_5058' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a05a7478-548d-4e6b-b7d0-17891a503e06' + "SNU-C2A": + description: '1 alleles of G12D mutation in KRAS gene. Established from a nude mouse xenograft. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap).' + meaning: 'rrid:CVCL_1709' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c51a1afa-d499-4630-8995-a61c9fd733b1' + "SOX10+ SLC": + description: 'Human induced pluripotent stem cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f3e07933-db64-48ea-bfa5-ed22a8647770' + "ST88-14": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_8916' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=202c110b-a5f1-49ab-acdc-e6e33a1c29bb' + "ST88-3": + meaning: 'rrid:CVCL_IU70' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b368f84e-f38b-4ff0-9458-fe5d8b91122d' + "STR-I-437-NF1": + description: 'From: INSERM, France.' + meaning: 'rrid:CVCL_Y599' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01040031-60ba-4da5-96b0-d4a0a2f9131b' + "STR-I-441-NF1": + description: 'From: INSERM, France.' + meaning: 'rrid:CVCL_Y600' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1372bf73-291f-48f9-9207-81120a299675' + "STR-I-443-NF1": + description: 'From: INSERM, France.' + meaning: 'rrid:CVCL_Y601' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5352596f-7192-473c-85b3-2aeb0fbf8e48' + "STS-26T": + description: 'Sporadic MPNST tumor cell line from a non-NF1 patient.' + meaning: 'rrid:CVCL_8917' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9a7997c9-9399-47ed-b44b-5b717be89ba3' + "STSA-1": + description: 'Mutation of NF1, p.Met877fs (c.2626dupT), Heterozygous (PubMed=31175136).' + meaning: 'rrid:CVCL_D274' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=203f9103-dd83-4879-8a5c-9d8541ae2267' + "SU.86.86": + description: '2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Hemizygous (PubMed=11115575).' + meaning: 'rrid:CVCL_3881' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=69abfb3f-7d1e-4433-b542-909b794dd72f' + "SW1463": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, PubMed=28683746, ATCC, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1718' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=42a7d7eb-f6df-45b8-80fc-242650606a84' + "SW1573": + description: '2 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Homozygous (PubMed=12068308, ATCC, Cosmic-CLP).' + meaning: 'rrid:CVCL_1720' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b600b899-2a05-44bb-bc3a-3359a45fa2f9' + "SW1990": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Homozygous (PubMed=12068308, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1723' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0d519727-94e9-4f9e-95d3-9227443c03fe' + "SW403": + description: '2 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746, Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_0545' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6ed7ecfd-36d3-4573-8e07-210c6088c3a7' + "SW480": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=20570890, PubMed=24755471, PubMed=28683746, DepMap).' + meaning: 'rrid:CVCL_0546' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2b79f24b-7362-4687-8c66-03bcb6a26ab3' + "SW620": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Homozygous (PubMed=12068308, PubMed=17088437, PubMed=20570890, PubMed=24755471, PubMed=28683746).' + meaning: 'rrid:CVCL_0547' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cf15506-fb63-49a8-b36e-6a28a67b4c6d' + "SW837": + description: '2 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Cys (c.34G>T), Heterozygous (PubMed=12068308, PubMed=20570890, PubMed=24755471, PubMed=28683746).' + meaning: 'rrid:CVCL_1729' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8d8a15b9-b7b8-42b7-ae4e-ca3ae1ac0be7' + "SW900": + description: '1 alleles of G12C mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (PubMed=12068308, Cosmic-CLP).' + meaning: 'rrid:CVCL_1731' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=880c525a-f1df-49df-afe5-61ad07304c6a' + "SZ-NF1": + description: 'Human embryonic stem cell line derived from an embryo with an NF1 mutation.' + meaning: 'rrid:CVCL_YL57' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=33cdb482-618e-4489-87d9-3139cc7c6a49' + "SZ-NF2": + description: 'Human embryonic stem cell line derived from an embryo with an NF1 mutation.' + meaning: 'rrid:CVCL_YL58' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc2045df-5ebf-4491-b5b1-88d65e59b228' + "SZ-NF4": + description: 'Human embryonic stem cell line derived from an embryo with an NF1 mutation.' + meaning: 'rrid:CVCL_YL59' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=09c988ab-765a-44ca-b2d7-1957b729208e' + "SZ-NF6": + description: 'From: Shaare Zedek Medical Center, The Hebrew University, Jerusalem, Israel., Mutation of NF1, c.4269+1G>C, Unspecified zygosity (Direct author submission)' + meaning: 'rrid:CVCL_YY00' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bf7ae798-a355-4b78-b1c3-6c82e3f917a7' + "Schwann cell NF1 -/- (iPN97.4 #24)": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- (iPN97.4 #24)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=234515dd-7c28-4172-83c7-59dddfa22acb' + "Schwann cell NF1 -/- with R681X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R681X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=faf29a50-3168-4ccd-a484-f2a78a026af3' + "Schwann cell NF1 -/- with R816X mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with R816X mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a3e5460-3d5b-45f9-995d-25bd49c06f34' + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA": + description: '[From GFF:] This cell line is in development and not comprehensively characterized. Please contact the investigator for more information. Schwann cell NF1 -/- with WT tagged mNf1 cDNA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3beebac1-95b0-4834-9008-19f7d268fc5b' + "ScienCell Schwann cells": + description: '[From ScienCell:] HSC from ScienCell Research Laboratories are isolated from human spinal nerve. (editorial note: these cells likely come from multiple donors)' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b751b5d4-56e6-42a2-a2dc-289f90c6dd82' + "T265": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_S805' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=6419dd0d-1937-4ecf-bf01-876632ae0f54' + "T351": + description: 'Mutation of NF1, p.Gln28Ter (c.82C>T), Homozygous (PubMed=30737244).' + meaning: 'rrid:CVCL_M977' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a29e2129-bee7-4d37-b0b6-c933f6e4bf84' + "T3M-10": + description: '1 alleles of G12D mutation in KRAS gene. Mutation of KRAS, p.Gly12Asp (c.35G>A), Heterozygous (DepMap).' + meaning: 'rrid:CVCL_8067' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9c2fbf5a-1c45-43f0-87bb-bb97ea9062f0' + "T84": + description: '1 alleles of G13D mutation in KRAS gene. Established from a xenograft produced by subcutaneous injection of the tumor cells into BALB/c nude mice. Mutation of KRAS, p.Gly13Asp (c.38G>A), Heterozygous ...' + meaning: 'rrid:CVCL_0555' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=281f0309-ec7d-443a-850f-9327e36c9b9f' + "TM-31": + meaning: 'rrid:CVCL_6735' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb9f27dd-53d0-44c2-a1e9-21a7bbd08fb1' + "TR14": + meaning: 'rrid:CVCL_B474' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e8ec4106-295f-4fa3-b744-40b6f9b68d38' + "U-87MG ATCC IDH1 p.R132H": + description: 'Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line).' + meaning: 'rrid:CVCL_UE09' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2eb64d9c-3481-455d-b2e4-b9d297ed6366' + "U-87MG ATCC IDH1 p.R132H-Luc2": + description: 'Stably expresses firefly luciferase under the control of the human EF-1 alpha promoter. Mutation of NF1, p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT), Heterozygous (from parent cell line)...' + meaning: 'rrid:CVCL_UR35' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64615ea4-6879-49ff-8f10-18c6710cb33c' + "U87-NF1-419": + description: 'Generated U87-NF1-419 to evaluate the role of circNF1-419 on cell cycle, apoptosis, proliferation, tumor growth and metabolic regulation' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8eee8013-cc31-43a4-903e-a5db2201e5f0' + "UCD65": + description: 'Established from a patient-derived xenograft. ER/PR-positive and ERBB2-negative. Mutation of NF1, p.Leu792fs*2 (c.2372dupT), Unspecified zygosity (PubMed=32576280).' + meaning: 'rrid:CVCL_ZV44' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=07d262bf-6db9-4825-a25b-b58322b02436' + "UHG-NP": + meaning: 'rrid:CVCL_A436' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=91cec0db-b483-4674-9636-e2fc4a91bf61' + "WT ES": + description: '[From GFF:] WT ES' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1097f821-56c3-4e51-bcd3-f84aef506e3a' + "WW165": + meaning: 'rrid:CVCL_G321' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1ef44c14-d0a5-4933-b433-88da4ec1e30c' + "WZJ": + description: 'From a surgically excised pNF specimen of a 12-year-old boy with NF1' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cb814003-cd22-430d-a3b7-e387ef8eac76' + "XF": + meaning: 'rrid:CVCL_6E64' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c2a2dca4-ebcc-4c8e-94c8-c867beaca9ab' + "XL110": + meaning: 'rrid:CVCL_T702' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0ee4d8e-2435-4e4a-bcc7-051d93fe686a' + "YAPC": + description: '1 alleles of G12V mutation in KRAS gene. Mutation of KRAS, p.Gly12Val (c.35G>T), Heterozygous (Cosmic-CLP, DepMap).' + meaning: 'rrid:CVCL_1794' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f51cbf29-987e-4950-9b46-1a607d5413a1' + "YST-1": + description: 'Schwannoma cell line, potentially mischaracterized in some cases as a sporadic MPNST cell line.' + meaning: 'rrid:CVCL_5192' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=617cb183-3377-4473-8ad8-2f6472bce1fa' + "YUAME": + description: 'Mutation of HRAS, p.Gly13Arg (c.37G>C), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_EI13' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df7e5a09-048e-4281-9fbb-52d3ce6cfa15' + "YUAVEY": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K001' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f87dbfd5-c5ea-4a76-b226-f7282caf042f' + "YUBEL": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J515' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e5c24057-9be9-433d-bba7-c49ca49cdca6' + "YUBUNE": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J516' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7a900c25-09ab-4a7b-b09c-04f7b72b3830' + "YUCAL": + meaning: 'rrid:CVCL_J532' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f1b65d6a-eb4a-4b19-8952-ce42b28b88ad' + "YUCAS": + description: 'Mutation of NF1, p.Ile679Aspfs*21 (c.2033dupC), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J065' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d21f9de9-7ceb-434d-b940-f2c9781fade9' + "YUCHER": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J517' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0f00fc26-31a0-464f-94a5-63e49d2deb0d' + "YUCHIME": + description: 'Mutation of NF1, p.Lys1714Asn, Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_EI14' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=64b1f481-af8d-47b8-b72a-8efcc2551ac3' + "YUCHUFA": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K003' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=730fff1a-f05a-4ef3-9166-31066a998e01' + "YUCINJ": + meaning: 'rrid:CVCL_K004' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=74c1381d-28e3-483c-8549-2effe3e005c2' + "YUCLAT": + description: 'Mutation of NF1, p.Ser2496Phe (c.7487C>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J518' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a58ef8da-482f-4939-88b0-f48fc791ceb7' + "YUCOT": + meaning: 'rrid:CVCL_J066' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=385bf0ee-9d93-4d01-ab72-767e2f07b5c5' + "YUCYLO": + meaning: 'rrid:CVCL_EI15' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=270fe506-9979-4df5-864a-2f0267e6e0f3' + "YUDATE": + meaning: 'rrid:CVCL_K006' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe88fad9-bf75-4bd8-8cc3-c05fec76fc5e' + "YUDEDE": + description: 'Mutation of NRAS, p.Gln61His (c.183A>T), Heterozygous (PubMed=20149136, PubMed=26214590).' + meaning: 'rrid:CVCL_G322' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=1cef36cc-a45e-4af4-aaff-d929b7f90544' + "YUDEW": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J519' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fe05e40-087b-436a-a222-18e7b4061643' + "YUDOSO": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Heterozygous (PubMed=20149136, PubMed=26214590).' + meaning: 'rrid:CVCL_G323' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9ad85e3f-886e-4e2c-ae51-f07be69d74a3' + "YUDUTY": + description: 'Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K007' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=72a07165-cd79-4a3d-ae4f-9b79578ea974' + "YUFIC": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Heterozygous (PubMed=20149136, PubMed=26214590).' + meaning: 'rrid:CVCL_G324' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=abd508df-8730-4ae9-abae-f544616c2ee5' + "YUGANK": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K009' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ab474b0-8f19-407d-a85e-3f12dff66075' + "YUGASP": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J520' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c96e7008-ebaf-4a4b-9d11-acc1cd9cf05b' + "YUGATOR": + description: 'Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_EI17' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5ea076a0-c21c-4bbc-b379-13b30c11a5fd' + "YUGEN8": + meaning: 'rrid:CVCL_A744' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=01611630-bca0-4923-9934-f8c2690b9c7e' + "YUGOE": + description: 'Mutation of NRAS, p.Gly12Val (c.35G>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J067' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f2fcbabd-a6f6-439b-87c0-c1c6dde92128' + "YUHEF": + description: 'Mutation of NF1, p.Gln853Ter (c.2557C>T), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Lys2552Thrfs*2, Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_G326' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8cc9b6b-d1fc-4e77-8f10-3ca5737bcd5c' + "YUKADI": + meaning: 'rrid:CVCL_K011' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8667847-6e03-4db3-ae9a-53bccac0147b' + "YUKIM": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_G328' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=39e7b045-3bca-47cf-9cd5-e070beda179c' + "YUKOLI": + meaning: 'rrid:CVCL_G329' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e124f7a-e2f4-4e63-965e-f4385c1f7f17' + "YUKSI": + meaning: 'rrid:CVCL_J068' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd13dcdf-bc8b-4d1f-8a53-8409cc3eb7a2' + "YULAPE": + description: 'Mutation of NRAS, p.Gln61His (c.183A>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K013' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=924186ef-bb8f-46aa-9ef2-bac3a04bdf6b' + "YULAXER": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K014' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=97c08096-3364-4d31-881c-c9d40e19daa5' + "YULOCUS": + description: 'Mutation of KRAS, p.Gly12Ile (c.34_35GG>AT) (c.34_35delinsAT), Unspecified zygosity (PubMed=26214590). Mutation of NF1, p.Gln2239Ter (c.6715C>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_EI19' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0bea258-655e-4a9b-a213-48aa86ac42d6' + "YULOMA": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K015' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d0c66ec1-78dc-4dec-9c3a-f2684b836cee' + "YULONE": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J523' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d9e160e6-76ae-4ae8-8c98-2ea114f6d769' + "YULOVY": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Heterozygous (PubMed=20149136, PubMed=26214590).' + meaning: 'rrid:CVCL_G330' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=384a1121-6aa6-4d4b-8aab-e4539e9d2f26' + "YUMAC": + meaning: 'rrid:CVCL_A745' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=696fac03-8787-4298-927c-3848d707f1bb' + "YUMINE": + meaning: 'rrid:CVCL_K016' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3e8c85c7-6714-49ab-83a8-8b0d9338bc03' + "YUMOBER": + description: 'Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_EI20' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cc4a3b69-b7ba-4395-883f-88ff0fc099c2' + "YUMUT": + meaning: 'rrid:CVCL_G331' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=fe79218f-2f91-47f6-a285-c265afbc1a00' + "YUNACK": + meaning: 'rrid:CVCL_EI21' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=913f5cef-7da3-44f9-8015-458f6993ea08' + "YUNIBO": + meaning: 'rrid:CVCL_J535' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a4990cf1-b921-45f1-94f6-1b286efeb1bb' + "YUPAC7": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_EI22' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ffbad5d9-74c8-4a48-8476-8a1a254b63eb' + "YUPEET": + meaning: 'rrid:CVCL_K018' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98f2d2a8-f264-4949-8d77-6a5e895d3708' + "YUPLA": + description: 'Mutation of NRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J069' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=47287b25-40be-4a08-bfa7-94da91b45c08' + "YUPOM": + meaning: 'rrid:CVCL_EI23' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f383e78a-772f-466a-a33b-69ca2864093e' + "YURDE": + meaning: 'rrid:CVCL_K019' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=0104b0cf-9664-4f95-854b-04f9146af2be' + "YURED": + description: 'Mutation of NF1, p.Leu972Pro (c.2915T>C), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K020' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cfa26941-984f-4a81-8314-f35c4e13e8bd' + "YURIF": + meaning: 'rrid:CVCL_B485' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=9fdfb9ef-767c-4f61-aea2-1b9495f89478' + "YURKEN": + description: 'Mutation of NF1, p.Pro228Ser (c.682C>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K021' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5fbbf3e3-b922-4a20-9720-b175c2260d14' + "YUROB": + description: 'Mutation of HRAS, p.Gln61Lys (c.181C>A), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_B486' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4cef2d2-31aa-4cd8-90a2-25584fc0e1e0' + "YUROL": + meaning: 'rrid:CVCL_J070' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f4f972c-992a-4f71-80d7-b3ce3403e0f8' + "YUSARI": + meaning: 'rrid:CVCL_K022' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=baf37457-11ec-4540-8e2b-28e51a6804d7' + "YUSIK": + meaning: 'rrid:CVCL_B487' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5631551-e263-4ed3-b2d6-8a31f6913e63' + "YUSIPU": + meaning: 'rrid:CVCL_EI16' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=e50b8062-cdc9-406d-af28-187b4c50995e' + "YUSIT1": + meaning: 'rrid:CVCL_A747' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=21c31a9f-36c6-4e3e-a5d4-abac01667a79' + "YUSIV": + meaning: 'rrid:CVCL_G332' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=db0bd299-eaf1-475d-81f9-15feb63fc6e3' + "YUSTE": + meaning: 'rrid:CVCL_J527' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=37657790-e578-4f21-9127-c6972206b407' + "YUSUBA": + meaning: 'rrid:CVCL_K023' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5ed8a55-c03f-467a-9381-58e92ade9f74' + "YUSWI": + meaning: 'rrid:CVCL_K024' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=77b38c3b-775d-4452-8782-13dd5f069146' + "YUTER": + description: 'Mutation of NRAS, p.Gln61Leu (c.182A>T), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_K025' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4034cf5b-c84f-4b22-ae06-d60edc183621' + "YUTICA": + description: 'Mutation of NF1, p.Pro1667Leu (c.5000C>T), Unspecified zygosity (PubMed=26214590). Mutation of NRAS, p.Gln61Arg (c.182A>G), Unspecified zygosity (PubMed=26214590).' + meaning: 'rrid:CVCL_J071' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f8ed167e-22b3-4ab1-a98f-65581c1bc8ab' + "YUWAGE": + meaning: 'rrid:CVCL_K026' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=592cf430-f5fd-4a97-936f-56de2bb5bc3b' + "YUWALI": + meaning: 'rrid:CVCL_K027' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bb1c24cb-9912-4b7d-89ca-b97399234671' + "YUWHIM": + meaning: 'rrid:CVCL_K028' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=cf7ded95-9f27-4cac-9753-d89a9b157b94' + "YUZAZ": + meaning: 'rrid:CVCL_EI18' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=84a6d041-7d20-4a92-8def-55e86ee45062' + "YUZEAL": + meaning: 'rrid:CVCL_K029' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=23aa4d92-5bae-4bee-b506-3a8484f58a2a' + "YUZEST": + meaning: 'rrid:CVCL_EI24' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ca2aaf2d-1dc7-4515-9475-ac07ae59152c' + "ZX2021H": + description: 'Mutation of NF1, p.Cys2134Tyrfs*8 (c.6401_6402del) (p.L2133fs, c.6398_6399del), Unspecified zygosity (PubMed=35297208).' + meaning: 'rrid:CVCL_B6ZD' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=08c395bc-b13c-42fa-8b99-ba6864c65928' + "c.1149C > A NF1-mutant hiPSCs": + description: 'NF1 patient-derived hiPSC line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ec8883f5-db93-4c66-9970-792b71b653ac' + "c.1185+1G > A NF1-mutant hiPSCs": + description: 'NF1 patient-derived hiPSC line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3978a8ca-aad8-49f5-a513-70b5acd0f92e' + "c.3431-32_dupGT NF1-mutant hiPSCs": + description: 'NF1 patient-derived hiPSC line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=831ba769-4809-4e31-9214-23bfb0377c19' + "c.5425C > T NF1-mutant hiPSCs": + description: 'NF1 patient-derived hiPSC line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3f5dbc86-c52d-4713-8a03-ddf3ae42695f' + "c.6619C > T NF1-mutant hiPSCs": + description: 'NF1 patient-derived hiPSC line' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13be6b59-6b84-4d38-add9-3e87631bddf3' + "cNF00.10a": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF00.10a).' + meaning: 'rrid:CVCL_B9UZ' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad2e271b-55ac-44ae-b39d-f1a6d76e1dc3' + "cNF04.9a": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF04.9a).' + meaning: 'rrid:CVCL_B9VB' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c5b9e065-6855-4a11-bceb-681d8e82ae5e' + "cNF97.2a": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2a).' + meaning: 'rrid:CVCL_B9V1' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=d390b3f3-fea7-46d2-9bb7-dc72d59b2ccc' + "cNF97.2b": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF97.2b).' + meaning: 'rrid:CVCL_B9V2' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b4987f0a-67ec-4f13-96f1-9443aac6e5ac' + "cNF98.4c": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4c).' + meaning: 'rrid:CVCL_B9V5' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=df513bb8-697a-4cac-ae6c-5aca6113ac24' + "cNF98.4d": + description: 'A primary cutaneous neurofibroma cell line; not broadly available. See the immortalized version (icNF98.4d).' + meaning: 'rrid:CVCL_B9V6' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=882101e0-1207-4323-a354-6d5a642e6ca3' + "hTERT NF1 ipNF00.6": + description: 'Derived from a plexiform neurofibroma.' + meaning: 'rrid:CVCL_UI76' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a8f48ce7-438c-4564-a70b-020abc96d5fe' + "hTERT NF1 ipNF03.3": + description: 'Derived from a plexiform neurofibroma.' + meaning: 'rrid:CVCL_UI77' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=f21cb7db-ee85-48a7-8f41-e4603238bede' + "hTERT NF1 ipNF04.4": + description: 'Derived from a plexiform neurofibroma.' + meaning: 'rrid:CVCL_UI78' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8fdc5f7a-ef8c-4193-a5c0-04577c3b134d' + "hTERT NF1 ipNF05.5": + description: 'Derived from a plexiform neurofibroma growing on a hand.' + meaning: 'rrid:CVCL_UI71' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=5502caf5-4cf1-418f-bf50-164cfa316b0f' + "hTERT NF1 ipNF05.5 (Mixed clones)": + description: 'Derived from a plexiform neurofibroma growing on a hand.' + meaning: 'rrid:CVCL_UI72' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=844b598c-0171-4972-91c3-27aa21b45d52' + "hTERT NF1 ipNF95.11b C": + description: 'Derived from a plexiform neurofibroma growing on a brachial plexus.' + meaning: 'rrid:CVCL_UI67' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=be2333d6-6716-4d13-947d-41f4198497a4' + "hTERT NF1 ipNF95.11b C/T": + description: 'Derived from a plexiform neurofibroma growing on a brachial plexus.' + meaning: 'rrid:CVCL_UI68' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ab60aae5-7860-4d1d-bb02-208e6631c78b' + "hTERT NF1 ipNF95.6": + description: 'Derived from a plexiform neurofibroma growing on cranial nerve XII.' + meaning: 'rrid:CVCL_UI70' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b44361f2-9021-4920-901a-b1a1f9143f97' + "hTERT NF1 ipn06.2 A": + description: 'Derived from a pleural plexiform neurofibroma.' + meaning: 'rrid:CVCL_UI74' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3dedf9d2-614c-4cf9-8d18-aff8aa2dc0eb' + "hTERT NF1 ipnNF09.4": + description: 'Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation.' + meaning: 'rrid:CVCL_UI73' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e0602ff-e3e6-438e-9fb7-c7abc1dd4304' + "hTERT NF1 ipnNF95.11c": + description: 'Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation.' + meaning: 'rrid:CVCL_UI69' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=2c4c8b02-f12e-4a17-a408-38ae88dd841d' + "hTERT NF1 sipnNF95.12B": + description: 'Derived from a peripheral nerve in a neurofibromatosis type 1 patient. No detectable somatic NF1 mutation.' + meaning: 'rrid:CVCL_UI75' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=98beda5b-9b28-4119-829a-2a0219d77af7' + "hTERT SC ipn97.4": + description: 'Healthy Schwann cells.' + meaning: 'rrid:CVCL_UI66' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=13ae2445-21e3-4b75-ae70-317a3d5ee40c' + "hTERT ipn02.3 2λ": + description: 'Derived from peripheral sciatic nerve from a donor without neurofibromatosis. No detectable NF1 mutation.' + meaning: 'rrid:CVCL_UI64' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a507bfd-7d2b-4238-b79a-83fe985c2cea' + "hTERT ipn02.8": + description: 'Derived from peripheral nerve from a donor without neurofibromatosis. No detectable NF1 mutation.' + meaning: 'rrid:CVCL_UI65' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3a8f5be4-aa22-48f2-9a76-9412010ecd45' + "i28cNF": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (28NF).' + meaning: 'rrid:CVCL_B9VA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=8e9ec3f3-5622-4f8f-a02c-34d8777c82b6' + "iPSC NF1 +/- BJFF.6 bkgd": + description: '[From GFF:] iPSC NF1 +/- BJFF.6 bkgd' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a0c91627-fad6-4d60-bf74-67623374eff8' + "iPSC NF1 WT": + description: '[From GFF:] iPSC NF1 WT BJFF.6 bkgd' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=4cf14492-2735-4e31-ab6a-75554b9ad298' + "iPSC Y489C; Exon 13 cryptic splice": + description: '[From GFF:] iPSC Y489C; Exon 13 cryptic splice, PGP1 cells' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=ad73cdb2-8add-48ff-b9f2-35a38132db84' + "icNF00.10a": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF00.10a).' + meaning: 'rrid:CVCL_B9V0' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=7ef2fd6f-9ba6-4e30-94fc-d4ffd61de6e6' + "icNF04.9a": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF04.9a).' + meaning: 'rrid:CVCL_B9VC' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=75d4b88a-a906-4f08-a9f8-66490328b9f1' + "icNF09.5": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF18.1a.' + meaning: 'rrid:CVCL_D3C7' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a9638c45-74f3-4d0d-8bac-67631503f437' + "icNF18.1a": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture. From the same patient as icNF09.5.' + meaning: 'rrid:CVCL_D3C8' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=347edbcd-0b43-4717-bdd2-2f6f31736e31' + "icNF93.1a": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture.' + meaning: 'rrid:CVCL_D3C9' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=dcf74355-dce9-4eac-bfda-00984a4e7f3c' + "icNF97.2a": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2a).' + meaning: 'rrid:CVCL_B9V3' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=a731535e-f7a6-4c6e-b0db-7f0d0979e69f' + "icNF97.2b": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF97.2b).' + meaning: 'rrid:CVCL_B9V4' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=eb920757-ad44-4705-815e-31b5bd6105f5' + "icNF97.5": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture.' + meaning: 'rrid:CVCL_D3CA' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=3003d963-fb4b-44e0-9b4c-97c5df6d6661' + "icNF98.4c": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4c).' + meaning: 'rrid:CVCL_B9V7' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=46da7a41-c654-426e-bfb7-361caf4d3c4c' + "icNF98.4d": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture (cNF98.4d)' + meaning: 'rrid:CVCL_B9V8' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=bd74fd9f-6357-40d5-8569-96883628fb1a' + "icNF99.1": + description: 'An hTERT/CDK4-immortalized cutaneous neurofibroma cell line derived from a primary cell culture.' + meaning: 'rrid:CVCL_D3CB' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=27004264-d872-493f-8668-ec4d2425cdc2' + "ipNF08.1.5": + description: 'An hTERT/CDK4-immortalized plexiform neurofibroma cell line derived from a primary cell culture.' + meaning: 'rrid:CVCL_D3CC' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=878d9455-2383-4427-88b3-de4fb28de131' + "sNF02.2": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_K280' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=b72d99fd-ee1e-42ec-92b6-9f89e375cce1' + "sNF94.3": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_K164' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=504647eb-6b60-492a-bb51-3ab025830f51' + "sNF96.2": + description: 'MPNST tumor cell line from an NF1 patient.' + meaning: 'rrid:CVCL_K281' + source: 'https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId=c9a87975-378b-4930-8fda-e5896c42c86c' diff --git a/modules/Template/Data_Base.yaml b/modules/Template/Data_Base.yaml index f25e3519..71090a39 100644 --- a/modules/Template/Data_Base.yaml +++ b/modules/Template/Data_Base.yaml @@ -28,8 +28,11 @@ classes: files) from experimental assays involving biosamples. Donor/individual attributes (species, sex, age, diagnosis) describe the original donor (e.g., human patient tumor). For cell lines, individualID references syn51730943. Model attributes - (modelSpecies, modelSex, modelAge) describe any animal model host used. antibodyID - and geneticReagentID reference treatments/reagents.' + (modelSystemType, modelSpecies, cellLineCategory, cellLineGeneticDisorder, modelSystemName, + modelSex, modelAge) describe model system used. Filter fields (modelSystemType, + modelSpecies, cellLineCategory, cellLineGeneticDisorder) must appear before modelSystemName + to enable conditional filtering in Synapse curator grid. antibodyID and geneticReagentID + reference treatments/reagents.' is_a: FileBasedTemplate slots: - dataType @@ -44,8 +47,11 @@ classes: - nf1Genotype - nf2Genotype - tumorType - - modelSystemName + - modelSystemType - modelSpecies + - cellLineCategory + - cellLineGeneticDisorder + - modelSystemName - modelSex - modelAge - modelAgeUnit diff --git a/modules/props.yaml b/modules/props.yaml index 6d1a43d8..8a18b818 100644 --- a/modules/props.yaml +++ b/modules/props.yaml @@ -845,8 +845,24 @@ slots: range: MultipleImagingDiagnosisEnum required: false title: Meningioma + modelSystemType: + description: Type of model system used in the study (e.g., cell line, animal model, organoid, or patient-derived xenograft). This field helps filter available model system names and is REQUIRED for conditional dropdown filtering. + range: ModelSystemTypeEnum + title: Model System Type + required: true + cellLineCategory: + description: Category of cell line based on origin, disease type, or characteristics. Used to filter cell line options when modelSystemType is 'cell line'. REQUIRED for conditional dropdown filtering when using cell lines. + range: CellLineCategoryEnum + title: Cell Line Category + required: true + cellLineGeneticDisorder: + description: Genetic disorder associated with the cell line (e.g., Neurofibromatosis type 1, NF2, Schwannomatosis). Used as an additional filter for cell lines. REQUIRED for conditional dropdown filtering when using cell lines. + range: CellLineGeneticDisorderEnum + title: Cell Line Genetic Disorder + required: true modelSystemName: annotations: + requiresDependency: modelSystemType modelSpecies cellLineCategory cellLineGeneticDisorder validationRules: list like any_of: - range: CellLineModel @@ -858,9 +874,9 @@ slots: title: Model System Name required: false modelSpecies: - description: Species of the animal model used (e.g., for xenograft experiments). Distinct from donor species. References species from model in syn51730943. + description: Species of the animal model used (e.g., for xenograft experiments). Distinct from donor species. References species from model in syn51730943. REQUIRED for conditional dropdown filtering. range: SpeciesEnum - required: false + required: true modelSex: any_of: - range: SexEnum diff --git a/registered-json-schemas/AffinityProteomicsTemplate.json b/registered-json-schemas/AffinityProteomicsTemplate.json index 65ad2e26..944344a0 100644 --- a/registered-json-schemas/AffinityProteomicsTemplate.json +++ b/registered-json-schemas/AffinityProteomicsTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for affinity-based proteomics data including antibody arrays (RPPA) and aptamer-based platforms (SomaScan). For antibody-based assays (RPPA), provide antibodyID. For aptamer-based assays (SomaScan), provide proteomicsPanel, panelVersion, and normalizationMethod.", @@ -227,6 +1259,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -235,22 +1270,34 @@ }, "proteomicsPanel": { "description": "Name or identifier for the proteomics assay panel used (e.g., SomaScan 7K, Olink Explore 3072).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "proteomicsPanel" }, "panelVersion": { "description": "Version of the assay panel used.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "panelVersion" }, "normalizationMethod": { "description": "Method used to normalize the data (e.g., plate calibration, median normalization, log2 transformation).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "normalizationMethod" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -269,7 +1316,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "assay": { @@ -293,9 +1343,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -538,6 +1620,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -554,7 +1639,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -572,14 +1660,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -605,63 +1717,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -715,13 +1874,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -734,32 +1886,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -772,40 +1899,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -813,93 +1966,30 @@ "MPNST-92", "MUG-Mel1", "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -915,8 +2005,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1084,52 +2172,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1198,51 +2252,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1275,98 +2387,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1376,27 +2489,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1416,31 +2528,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1476,7 +2636,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1539,14 +2702,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1641,9 +2828,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "AffinityProteomicsTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/AnimalIndividualTemplate.json b/registered-json-schemas/AnimalIndividualTemplate.json index ab10757f..646f8ea2 100644 --- a/registered-json-schemas/AnimalIndividualTemplate.json +++ b/registered-json-schemas/AnimalIndividualTemplate.json @@ -12,19 +12,46 @@ "title": "individualID" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -96,32 +123,69 @@ "type": "string" }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "germlineMutation": { "description": "The individual's actual germline mutation.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "germlineMutation" }, "species": { @@ -147,63 +211,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -257,13 +368,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -276,32 +380,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -314,134 +393,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", - "HTh74", - "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", - "MCF10A_NF1_1", - "MCF10A_NF1_7A1", - "MCF10A_NF1_7B2", "MCRIi020-A", "MCRIi021-A", "MCRIi022-A", "MCRIi023-A", - "MH/Nike", - "MIA PaCa-2", - "MPNST 724", - "MPNST-14", - "MPNST-642", - "MPNST-90", - "MPNST-91", - "MPNST-92", - "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", + "HTh74", + "HTh74 clone 7", + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2", + "Mes-9", + "MH/Nike", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "MUG-Mel1", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -457,8 +499,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -626,52 +666,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -740,51 +746,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", - "icNF93.1a", - "icNF97.2a", - "icNF97.2b", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", + "icNF93.1a", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -817,98 +881,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -918,27 +983,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -958,7 +1022,10 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, "modelSpecies": { @@ -980,19 +1047,46 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -1013,8 +1107,1461 @@ "required": [ "individualID", "diagnosis", - "species" + "species", + "modelSpecies" ], "title": "AnimalIndividualTemplate", - "type": "object" + "type": "object", + "allOf": [ + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + } + ], + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/BehavioralAssayTemplate.json b/registered-json-schemas/BehavioralAssayTemplate.json index c55d918e..505d5195 100644 --- a/registered-json-schemas/BehavioralAssayTemplate.json +++ b/registered-json-schemas/BehavioralAssayTemplate.json @@ -109,6 +109,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for behavioral assay data from model organisms measuring behaviors such as feeding, learning, memory, motor coordination, and activity patterns.", @@ -118,63 +1150,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -228,13 +1307,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -247,32 +1319,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -285,40 +1332,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -327,92 +1400,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -428,8 +1438,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -595,54 +1603,20 @@ "SK-N-FI", "SK-N-SH", "SMBCi003-A", - "SMBCi003-B", - "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", - "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", + "SMBCi003-B", + "SMBCi003-C", + "ST88-3", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -711,51 +1685,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -788,98 +1820,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -889,27 +1922,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -929,7 +1961,10 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, "experimentalFactor": { @@ -949,12 +1984,18 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -988,7 +2029,10 @@ }, "genePerturbed": { "description": "The HUGO gene symbol for the gene that is perturbed.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "genePerturbed" }, "genePerturbationType": { @@ -1014,12 +2058,18 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -1222,6 +2272,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -1282,6 +2335,35 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "dataSubtype": { "description": "Categorizes data based on its processing state. This is the main classification axis used for data types. Not all data types can use this dimensions (e.g. clinical data).", "enum": [ @@ -1520,6 +2602,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -1536,7 +2621,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -1554,14 +2642,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -1582,28 +2694,73 @@ "title": "species", "type": "string" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1653,14 +2810,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1751,9 +2932,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "BehavioralAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/BiospecimenTemplate.json b/registered-json-schemas/BiospecimenTemplate.json index 3f63a988..91e9735e 100644 --- a/registered-json-schemas/BiospecimenTemplate.json +++ b/registered-json-schemas/BiospecimenTemplate.json @@ -13,7 +13,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "specimenID": { @@ -23,7 +26,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "tumorType": { @@ -112,7 +118,10 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "modelSystemName": { @@ -120,63 +129,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -230,13 +286,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -249,32 +298,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -287,134 +311,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", - "HTh74", - "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", - "MCF10A_NF1_1", - "MCF10A_NF1_7A1", - "MCF10A_NF1_7B2", "MCRIi020-A", "MCRIi021-A", "MCRIi022-A", "MCRIi023-A", - "MH/Nike", - "MIA PaCa-2", - "MPNST 724", - "MPNST-14", - "MPNST-642", - "MPNST-90", - "MPNST-91", - "MPNST-92", - "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", + "HTh74", + "HTh74 clone 7", + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2", + "Mes-9", + "MH/Nike", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "MUG-Mel1", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -430,8 +417,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -599,52 +584,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -713,51 +664,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", - "icNF93.1a", - "icNF97.2a", - "icNF97.2b", - "icNF97.5", - "icNF98.4c", - "icNF98.4d", - "icNF99.1", - "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -790,98 +799,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -891,27 +901,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -931,7 +940,10 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, "modelSpecies": { @@ -953,19 +965,46 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -986,8 +1025,1461 @@ "required": [ "individualID", "specimenID", - "tumorType" + "tumorType", + "modelSpecies" ], "title": "BiospecimenTemplate", - "type": "object" + "type": "object", + "allOf": [ + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + } + ], + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/BulkSequencingAssayTemplate.json b/registered-json-schemas/BulkSequencingAssayTemplate.json index 90390177..1ee3e3ef 100644 --- a/registered-json-schemas/BulkSequencingAssayTemplate.json +++ b/registered-json-schemas/BulkSequencingAssayTemplate.json @@ -37,44 +37,1093 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "General template for raw (level 1) RNA/DNA data, i.e. sequence data from a sequencing assay.", "properties": { "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "runType": { @@ -141,32 +1190,50 @@ "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -185,7 +1252,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -374,6 +1444,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -418,9 +1491,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -694,6 +1799,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -710,7 +1818,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -728,14 +1839,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -761,63 +1896,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -871,13 +2053,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -890,32 +2065,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -928,40 +2078,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -970,92 +2146,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1071,8 +2184,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1240,52 +2351,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1354,51 +2431,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1431,98 +2566,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1532,27 +2668,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1572,31 +2707,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1644,7 +2827,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1693,14 +2879,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1814,9 +3024,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "BulkSequencingAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/CellTissuePhenotypingTemplate.json b/registered-json-schemas/CellTissuePhenotypingTemplate.json index 6d6ffdd8..141060ec 100644 --- a/registered-json-schemas/CellTissuePhenotypingTemplate.json +++ b/registered-json-schemas/CellTissuePhenotypingTemplate.json @@ -145,13 +145,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Data that characterizes cell/tissue morphology or physiology often in the context of different experimental conditions", "properties": { "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "specimenID": { @@ -161,7 +1196,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "modelSystemName": { @@ -169,63 +1207,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -279,13 +1364,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -298,32 +1376,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -336,40 +1389,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -378,92 +1457,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -479,8 +1495,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -647,53 +1661,19 @@ "SK-N-SH", "SMBCi003-A", "SMBCi003-B", - "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", - "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", + "SMBCi003-C", + "ST88-3", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -762,51 +1742,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -839,98 +1877,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -940,27 +1979,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -980,7 +2018,10 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, "experimentalFactor": { @@ -1000,12 +2041,18 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -1039,7 +2086,10 @@ }, "genePerturbed": { "description": "The HUGO gene symbol for the gene that is perturbed.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "genePerturbed" }, "genePerturbationType": { @@ -1065,12 +2115,18 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -1273,6 +2329,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -1488,6 +2547,35 @@ ], "title": "assay" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "dataSubtype": { "description": "Categorizes data based on its processing state. This is the main classification axis used for data types. Not all data types can use this dimensions (e.g. clinical data).", "enum": [ @@ -1839,6 +2927,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -1855,7 +2946,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -1873,14 +2967,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -1901,28 +3019,73 @@ "title": "species", "type": "string" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1972,14 +3135,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -2071,9 +3258,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "CellTissuePhenotypingTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ChIPSeqTemplate.json b/registered-json-schemas/ChIPSeqTemplate.json index 2952943a..ecb5c37e 100644 --- a/registered-json-schemas/ChIPSeqTemplate.json +++ b/registered-json-schemas/ChIPSeqTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing raw data from ChIP-Seq assays, typically used to identify DNA-protein interactions.", @@ -227,6 +1259,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -265,12 +1300,18 @@ }, "peakCallingAlgorithm": { "description": "A list of commonly used peak-calling algorithms for ChIP-Seq data analysis.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "peakCallingAlgorithm" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -289,7 +1330,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "assay": { @@ -332,17 +1376,55 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, "bisulfiteConversionKitID": { "description": "Name of kit used in bisulfite conversion.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "bisulfiteConversionKitID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -616,6 +1698,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -683,7 +1768,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -701,14 +1789,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -734,63 +1846,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -844,13 +2003,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -863,32 +2015,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -901,40 +2028,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -943,92 +2096,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1044,8 +2134,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1213,52 +2301,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1327,51 +2381,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1404,98 +2516,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1505,27 +2618,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1545,31 +2657,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1617,24 +2777,36 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1662,14 +2834,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1712,44 +2908,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1824,9 +3040,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ChIPSeqTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ClinicalAssayTemplate.json b/registered-json-schemas/ClinicalAssayTemplate.json index 83822342..e41b553c 100644 --- a/registered-json-schemas/ClinicalAssayTemplate.json +++ b/registered-json-schemas/ClinicalAssayTemplate.json @@ -55,6 +55,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "General template for typically tabular **individual-level** data. This can include repeated measures and a drug treatment context.", @@ -76,7 +1108,10 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "timepointUnit": { @@ -110,12 +1145,18 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -318,6 +1359,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -378,6 +1422,35 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "dataSubtype": { "description": "Categorizes data based on its processing state. This is the main classification axis used for data types. Not all data types can use this dimensions (e.g. clinical data).", "enum": [ @@ -394,6 +1467,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -560,6 +1697,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -576,7 +1716,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -594,14 +1737,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -627,63 +1794,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -737,13 +1951,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -756,32 +1963,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -794,134 +1976,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", - "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -937,8 +2082,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1106,52 +2249,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1220,51 +2329,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1297,98 +2464,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1398,27 +2566,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1438,31 +2605,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1512,14 +2727,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1610,9 +2849,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ClinicalAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/DataLandscape.json b/registered-json-schemas/DataLandscape.json index b5aab56f..8b5ce112 100644 --- a/registered-json-schemas/DataLandscape.json +++ b/registered-json-schemas/DataLandscape.json @@ -10,7 +10,10 @@ }, "aim": { "description": "Study context: The research aim within the study and associated with the expected dataset (e.g., 1 for Aim 1, 2 for Aim 2)", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "aim" }, "name": { @@ -20,12 +23,18 @@ }, "description": { "description": "Dataset identification: Short description of the dataset and experimental details.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "description" }, "dataLead": { "description": "Dataset identification: The person or team responsible for generating and curating this dataset", - "type": "string", + "type": [ + "string", + "null" + ], "title": "dataLead" }, "dataType": { @@ -95,7 +104,10 @@ ], "description": "Type of data represented by the entity (File, Dataset, etc.)." }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "dataType" }, "assay": { @@ -470,17 +482,26 @@ "deadline": { "description": "Project management: Target date for data to be uploaded for this dataset. This can be an estimate.", "format": "date", - "type": "string", + "type": [ + "string", + "null" + ], "title": "deadline" }, "milestone": { "description": "Project management: Reference to a milestone (aka \"progress report number\") associated with this dataset, e.g. '1' or '2.2'", - "type": "string", + "type": [ + "string", + "null" + ], "title": "milestone" }, "comments": { "description": "Project management: Additional comments or notes about this dataset", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" } }, diff --git a/registered-json-schemas/ElectrophysiologyAssayTemplate.json b/registered-json-schemas/ElectrophysiologyAssayTemplate.json index 6e8d2ecc..395bbced 100644 --- a/registered-json-schemas/ElectrophysiologyAssayTemplate.json +++ b/registered-json-schemas/ElectrophysiologyAssayTemplate.json @@ -55,6 +55,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for raw electrophysiology data (electrical recordings).", @@ -259,17 +1291,26 @@ "title": "Cell", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "cellType" }, "recordingSource": { "description": "Source of electrophysiology recording.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "recordingSource" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -288,17 +1329,26 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -501,6 +1551,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -586,9 +1639,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -841,6 +1926,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -857,7 +1945,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -875,14 +1966,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -908,63 +2023,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -1018,13 +2180,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -1037,32 +2192,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -1075,134 +2205,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1218,8 +2311,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1387,52 +2478,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1501,51 +2558,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1578,98 +2693,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1679,27 +2795,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1719,31 +2834,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1793,14 +2956,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1889,9 +3076,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ElectrophysiologyAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/EpidemiologyDataTemplate.json b/registered-json-schemas/EpidemiologyDataTemplate.json index e41e2862..f0655869 100644 --- a/registered-json-schemas/EpidemiologyDataTemplate.json +++ b/registered-json-schemas/EpidemiologyDataTemplate.json @@ -6,11 +6,78 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "populationCoverage": { "description": "Describes population coverage of the present data.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "populationCoverage" }, "epidemiologyMetric": { diff --git a/registered-json-schemas/EpigeneticsAssayTemplate.json b/registered-json-schemas/EpigeneticsAssayTemplate.json index 7fe0013d..c2ca22eb 100644 --- a/registered-json-schemas/EpigeneticsAssayTemplate.json +++ b/registered-json-schemas/EpigeneticsAssayTemplate.json @@ -37,6 +37,4886 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Alias for EpigenomicsAssayTemplate for backwards-compatibility.", @@ -1819,5 +6699,423 @@ "resourceType" ], "title": "EpigeneticsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/EpigenomicsAssayTemplate.json b/registered-json-schemas/EpigenomicsAssayTemplate.json index 33af2c05..72812523 100644 --- a/registered-json-schemas/EpigenomicsAssayTemplate.json +++ b/registered-json-schemas/EpigenomicsAssayTemplate.json @@ -37,18 +37,1056 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing raw data from epigenetics sequencing assays such as bisulfite sequencing.", "properties": { "bisulfiteConversionKitID": { "description": "Name of kit used in bisulfite conversion.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "bisulfiteConversionKitID" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -67,7 +1105,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -256,6 +1297,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -302,12 +1346,47 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -581,6 +1660,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -648,7 +1730,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -666,14 +1751,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -699,63 +1808,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -809,13 +1965,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -828,32 +1977,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -866,40 +1990,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -908,92 +2058,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1009,8 +2096,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1178,52 +2263,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1292,51 +2343,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1369,98 +2478,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1470,27 +2580,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1510,31 +2619,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1582,7 +2739,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1617,19 +2777,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1657,14 +2826,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1707,44 +2900,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1819,9 +3032,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "EpigenomicsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/FlowCytometryTemplate.json b/registered-json-schemas/FlowCytometryTemplate.json index 9a7c0bcc..5184e056 100644 --- a/registered-json-schemas/FlowCytometryTemplate.json +++ b/registered-json-schemas/FlowCytometryTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for flow cytometry assay", @@ -95,17 +1127,26 @@ "title": "Cell", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "cellType" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -308,6 +1349,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -393,9 +1437,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -648,6 +1724,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -664,7 +1743,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -682,14 +1764,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -715,63 +1821,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -825,13 +1978,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -844,32 +1990,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -882,134 +2003,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1025,8 +2109,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1194,52 +2276,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1308,51 +2356,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1385,98 +2491,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1486,27 +2593,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1526,31 +2632,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1600,14 +2754,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1696,9 +2874,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "FlowCytometryTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/GeneralMeasureDataTemplate.json b/registered-json-schemas/GeneralMeasureDataTemplate.json index 73da66be..10f68c41 100644 --- a/registered-json-schemas/GeneralMeasureDataTemplate.json +++ b/registered-json-schemas/GeneralMeasureDataTemplate.json @@ -145,6 +145,4886 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "General template for data in tabular form that aggregates tissue-level or cellular-level data.", @@ -2071,5 +6951,423 @@ "resourceType" ], "title": "GeneralMeasureDataTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/GenericDataResourceTemplate.json b/registered-json-schemas/GenericDataResourceTemplate.json index fc80773e..4baef738 100644 --- a/registered-json-schemas/GenericDataResourceTemplate.json +++ b/registered-json-schemas/GenericDataResourceTemplate.json @@ -314,7 +314,10 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "fileFormat": { diff --git a/registered-json-schemas/GenomicsArrayTemplate.json b/registered-json-schemas/GenomicsArrayTemplate.json index ebe914cb..3ff35791 100644 --- a/registered-json-schemas/GenomicsArrayTemplate.json +++ b/registered-json-schemas/GenomicsArrayTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "A template for describing raw data from array-based genomics/epigenomics, e.g. CEL files.", @@ -86,7 +1118,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -105,7 +1140,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -294,6 +1332,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -338,9 +1379,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -583,6 +1656,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -599,7 +1675,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -617,14 +1696,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -650,63 +1753,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -760,13 +1910,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -779,32 +1922,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -817,40 +1935,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -859,92 +2003,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -960,8 +2041,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1129,52 +2208,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1243,51 +2288,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1320,98 +2423,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1421,27 +2525,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1461,31 +2564,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1533,7 +2684,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "resourceType": { @@ -1552,14 +2706,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1672,9 +2850,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "GenomicsArrayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/GenomicsAssayTemplate.json b/registered-json-schemas/GenomicsAssayTemplate.json index 7b853264..a96b553a 100644 --- a/registered-json-schemas/GenomicsAssayTemplate.json +++ b/registered-json-schemas/GenomicsAssayTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Alias to BulkSequencingAssayTemplate, use for sequence data on a large scale when there is no template available that is more specific.", @@ -52,7 +1084,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -71,7 +1106,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -260,6 +1298,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -306,12 +1347,47 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -585,6 +1661,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -652,7 +1731,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -670,14 +1752,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -703,63 +1809,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -813,13 +1966,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -832,32 +1978,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -870,40 +1991,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -912,92 +2059,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1013,8 +2097,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1182,52 +2264,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1296,51 +2344,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1373,98 +2479,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1474,27 +2581,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1514,31 +2620,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1586,7 +2740,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1621,19 +2778,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1661,14 +2827,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1711,44 +2901,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1823,9 +3033,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "GenomicsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/GenomicsAssayTemplateExtended.json b/registered-json-schemas/GenomicsAssayTemplateExtended.json index b3c6da7e..79ebfa64 100644 --- a/registered-json-schemas/GenomicsAssayTemplateExtended.json +++ b/registered-json-schemas/GenomicsAssayTemplateExtended.json @@ -91,18 +91,1056 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Genomics assay template but with additional experiment data.", "properties": { "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -121,7 +1159,10 @@ }, "genePerturbed": { "description": "The HUGO gene symbol for the gene that is perturbed.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "genePerturbed" }, "genePerturbationTechnology": { @@ -147,12 +1188,18 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -171,7 +1218,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -360,6 +1410,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -406,9 +1459,41 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "dataSubtype": { "description": "Categorizes data based on its processing state. This is the main classification axis used for data types. Not all data types can use this dimensions (e.g. clinical data).", "enum": [ @@ -680,6 +1765,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -756,7 +1844,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -774,14 +1865,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -807,63 +1922,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -917,13 +2079,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -936,32 +2091,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -974,40 +2104,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -1016,92 +2172,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1117,8 +2210,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1286,52 +2377,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1400,51 +2457,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1477,98 +2592,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1578,27 +2694,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1618,31 +2733,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1690,7 +2853,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1725,19 +2891,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1765,14 +2940,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1815,44 +3014,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1927,9 +3146,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "GenomicsAssayTemplateExtended", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/HumanCohortTemplate.json b/registered-json-schemas/HumanCohortTemplate.json index b85bd16f..e46568f0 100644 --- a/registered-json-schemas/HumanCohortTemplate.json +++ b/registered-json-schemas/HumanCohortTemplate.json @@ -12,19 +12,46 @@ "title": "individualID" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -96,27 +123,61 @@ "type": "string" }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "germlineMutationIndicator": { diff --git a/registered-json-schemas/ImagingAssayTemplate.json b/registered-json-schemas/ImagingAssayTemplate.json index c2a0f784..3d82251f 100644 --- a/registered-json-schemas/ImagingAssayTemplate.json +++ b/registered-json-schemas/ImagingAssayTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "General template for describing imaging data.", @@ -103,17 +1135,26 @@ }, "assayTarget": { "description": "Target of the assay such as a HUGO gene symbol, cell type, or tissue region depending on the capabilities of the assay.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "assayTarget" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -316,6 +1357,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -363,9 +1407,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -384,6 +1460,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -557,6 +1697,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -573,7 +1716,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -591,14 +1737,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -624,63 +1794,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -734,13 +1951,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -753,32 +1963,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -791,134 +1976,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", - "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -934,8 +2082,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1103,52 +2249,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1217,51 +2329,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1294,98 +2464,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1395,27 +2566,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1435,31 +2605,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1509,14 +2727,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1605,9 +2847,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ImagingAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ImmunoMicroscopyTemplate.json b/registered-json-schemas/ImmunoMicroscopyTemplate.json index 05830a94..ce73c0e1 100644 --- a/registered-json-schemas/ImmunoMicroscopyTemplate.json +++ b/registered-json-schemas/ImmunoMicroscopyTemplate.json @@ -91,6 +91,4886 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing immunofluorescence or immunohistochemistry images.", @@ -1680,5 +6560,423 @@ "resourceType" ], "title": "ImmunoMicroscopyTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/KinomicsAssayTemplate.json b/registered-json-schemas/KinomicsAssayTemplate.json index af2339c9..bf4ec9d4 100644 --- a/registered-json-schemas/KinomicsAssayTemplate.json +++ b/registered-json-schemas/KinomicsAssayTemplate.json @@ -37,23 +37,1064 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for kinase activity profiling experiments such as LINCS or DiscoverX KINOMEscan panels that report percent control/inhibition across large kinase panels.", "properties": { "kinasePanel": { "description": "Name or identifier for the kinase assay panel, bead set, or profiling version used (e.g., DiscoverX scanMAX 468 kinases).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "kinasePanel" }, "kinaseReadoutType": { "description": "Metric reported for kinase activity measurements (e.g., percent control, percent inhibition, log2 fold change).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "kinaseReadoutType" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -72,7 +1113,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -261,6 +1305,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -288,9 +1335,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataCollectionMode": { @@ -534,6 +1613,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -550,7 +1632,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -568,14 +1653,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -601,63 +1710,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -711,13 +1867,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -730,32 +1879,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -768,40 +1892,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -809,93 +1959,30 @@ "MPNST-92", "MUG-Mel1", "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -911,8 +1998,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1080,52 +2165,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1194,51 +2245,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1271,98 +2380,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1372,27 +2482,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1412,31 +2521,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1472,7 +2629,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1512,14 +2672,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1615,9 +2799,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "KinomicsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/LightScatteringAssayTemplate.json b/registered-json-schemas/LightScatteringAssayTemplate.json index 7748ef5b..33a7e238 100644 --- a/registered-json-schemas/LightScatteringAssayTemplate.json +++ b/registered-json-schemas/LightScatteringAssayTemplate.json @@ -61,12 +61,18 @@ "properties": { "pH": { "description": "Numeric value for pH (range 0-14)", - "type": "number", + "type": [ + "number", + "null" + ], "title": "pH" }, "concentrationNaCl": { "description": "Numeric value for NaCl concentration", - "type": "string", + "type": [ + "string", + "null" + ], "title": "concentrationNaCl" }, "concentrationNaClUnit": { @@ -160,7 +166,10 @@ }, "concentrationMaterial": { "description": "Numeric value for concentration of the material", - "type": "number", + "type": [ + "number", + "null" + ], "title": "concentrationMaterial" }, "concentrationMaterialUnit": { @@ -269,7 +278,10 @@ }, "materialType": { "description": "Type of material in the characterization", - "type": "string", + "type": [ + "string", + "null" + ], "title": "materialType" }, "platform": { diff --git a/registered-json-schemas/MRIAssayTemplate.json b/registered-json-schemas/MRIAssayTemplate.json index 3e82ef71..09cd3f85 100644 --- a/registered-json-schemas/MRIAssayTemplate.json +++ b/registered-json-schemas/MRIAssayTemplate.json @@ -55,6 +55,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing MRI data.", @@ -98,12 +1130,18 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -122,7 +1160,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -325,6 +1366,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -374,17 +1418,55 @@ }, "assayTarget": { "description": "Target of the assay such as a HUGO gene symbol, cell type, or tissue region depending on the capabilities of the assay.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "assayTarget" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -403,6 +1485,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -576,6 +1722,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -592,7 +1741,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -610,14 +1762,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -643,63 +1819,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -753,13 +1976,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -772,32 +1988,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -810,134 +2001,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", - "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -953,8 +2107,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1122,52 +2274,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1236,51 +2354,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1313,98 +2489,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1414,27 +2591,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1454,31 +2630,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1561,14 +2785,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1657,9 +2905,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "MRIAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/MassSpecAssayTemplate.json b/registered-json-schemas/MassSpecAssayTemplate.json index 83781df7..c76de74a 100644 --- a/registered-json-schemas/MassSpecAssayTemplate.json +++ b/registered-json-schemas/MassSpecAssayTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for raw mass spec-based proteomics data.", @@ -48,7 +1080,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -67,7 +1102,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -256,6 +1294,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -283,9 +1324,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -524,6 +1597,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -540,7 +1616,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -558,14 +1637,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -591,63 +1694,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -701,13 +1851,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -720,32 +1863,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -758,40 +1876,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -799,93 +1943,30 @@ "MPNST-92", "MUG-Mel1", "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -901,8 +1982,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1070,52 +2149,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1184,51 +2229,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1261,98 +2364,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1362,27 +2466,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1402,31 +2505,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1462,7 +2613,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1502,14 +2656,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1605,9 +2783,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "MassSpecAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/MaterialScienceAssayTemplate.json b/registered-json-schemas/MaterialScienceAssayTemplate.json index ba83b46b..86f5a575 100644 --- a/registered-json-schemas/MaterialScienceAssayTemplate.json +++ b/registered-json-schemas/MaterialScienceAssayTemplate.json @@ -178,12 +178,18 @@ }, "materialType": { "description": "Type of material in the characterization", - "type": "string", + "type": [ + "string", + "null" + ], "title": "materialType" }, "concentrationMaterial": { "description": "Numeric value for concentration of the material", - "type": "number", + "type": [ + "number", + "null" + ], "title": "concentrationMaterial" }, "concentrationMaterialUnit": { @@ -198,7 +204,10 @@ }, "concentrationNaCl": { "description": "Numeric value for NaCl concentration", - "type": "string", + "type": [ + "string", + "null" + ], "title": "concentrationNaCl" }, "concentrationNaClUnit": { diff --git a/registered-json-schemas/MethylationArrayTemplate.json b/registered-json-schemas/MethylationArrayTemplate.json index 73586ada..0be336a4 100644 --- a/registered-json-schemas/MethylationArrayTemplate.json +++ b/registered-json-schemas/MethylationArrayTemplate.json @@ -37,33 +37,1080 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for raw data files (idat) from DNA methylation arrays.", "properties": { "chipID": { "description": "User-specified identifier for the chip used to perform the methylation microarray.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "chipID" }, "chipPosition": { "description": "User-specified identifier for the specific position on the chip that the sample was loaded into to perform the methylation microarray.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "chipPosition" }, "plateName": { "description": "User-specified identifier of the plate used to prepare the sample for analysis.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "plateName" }, "plateWell": { "description": "User-specified identifier for the specific well of the plate used to prepare the sample for analysis.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "plateWell" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -82,7 +1129,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -271,6 +1321,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -315,6 +1368,35 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "channel": { "description": "", "enum": [ @@ -327,7 +1409,10 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -570,6 +1655,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -586,7 +1674,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -604,14 +1695,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -637,63 +1752,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -747,13 +1909,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -766,32 +1921,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -804,40 +1934,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -846,92 +2002,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -947,8 +2040,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1116,52 +2207,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1230,51 +2287,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1307,98 +2422,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1408,27 +2524,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1448,31 +2563,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1520,7 +2683,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1572,14 +2738,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1692,9 +2882,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "MethylationArrayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/MicroscopyAssayTemplate.json b/registered-json-schemas/MicroscopyAssayTemplate.json index ffbea320..4e5bb2bd 100644 --- a/registered-json-schemas/MicroscopyAssayTemplate.json +++ b/registered-json-schemas/MicroscopyAssayTemplate.json @@ -91,13 +91,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for microscopy imaging data. For immunofluorescence or immunohistochemistry assays, provide antibodyID.", "properties": { "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "specimenID": { @@ -107,27 +1142,42 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "objective": { "description": "Microscope objective.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "objective" }, "nominalMagnification": { "description": "magnification of the lens as specified by the manufacturer - i.e. '60' is a 60X lens.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "nominalMagnification" }, "lensAperture": { "description": "Numerical aperture of the lens. Floating point value > 0.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "lensAperture" }, "workingDistance": { "description": "Working distance of the lens expressed as a floating point number > 0.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "workingDistance" }, "workingDistanceUnit": { @@ -144,7 +1194,10 @@ }, "immersion": { "description": "Immersion medium", - "type": "string", + "type": [ + "string", + "null" + ], "title": "immersion" }, "antibodyID": { @@ -333,6 +1386,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -341,7 +1397,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -401,17 +1460,55 @@ }, "assayTarget": { "description": "Target of the assay such as a HUGO gene symbol, cell type, or tissue region depending on the capabilities of the assay.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "assayTarget" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -430,6 +1527,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -603,6 +1764,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -619,7 +1783,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -637,14 +1804,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -670,63 +1861,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -780,13 +2018,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -799,32 +2030,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -837,134 +2043,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", - "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -980,8 +2149,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1149,52 +2316,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1263,51 +2396,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1340,98 +2531,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1441,27 +2633,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1481,31 +2672,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1579,14 +2818,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1676,9 +2939,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "MicroscopyAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/PdxGenomicsAssayTemplate.json b/registered-json-schemas/PdxGenomicsAssayTemplate.json index eb8fd079..35fc1b25 100644 --- a/registered-json-schemas/PdxGenomicsAssayTemplate.json +++ b/registered-json-schemas/PdxGenomicsAssayTemplate.json @@ -91,6 +91,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Raw genomics data from patient-derived xenograft (PDX) experiment, with additional PDX-relevant metadata.", @@ -108,7 +1140,10 @@ }, "transplantationRecipientSpecies": { "description": "Species into which donor was grown", - "type": "string", + "type": [ + "string", + "null" + ], "title": "transplantationRecipientSpecies" }, "transplantationRecipientTissue": { @@ -147,63 +1182,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -257,13 +1339,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -276,32 +1351,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -314,40 +1364,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -356,92 +1432,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -457,8 +1470,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -626,52 +1637,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -740,51 +1717,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -817,98 +1852,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -918,27 +1954,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -958,17 +1993,26 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -987,7 +2031,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -1006,7 +2053,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -1195,6 +2245,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -1241,12 +2294,47 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -1520,6 +2608,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -1596,7 +2687,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -1614,14 +2708,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -1642,28 +2760,73 @@ "title": "species", "type": "string" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1711,7 +2874,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1746,19 +2912,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1786,14 +2961,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1836,44 +3035,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "transplantationRecipientTissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1948,9 +3167,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "PdxGenomicsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/PharmacokineticsAssayTemplate.json b/registered-json-schemas/PharmacokineticsAssayTemplate.json index 3d977a09..00721ccb 100644 --- a/registered-json-schemas/PharmacokineticsAssayTemplate.json +++ b/registered-json-schemas/PharmacokineticsAssayTemplate.json @@ -73,6 +73,4886 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Generic template for describing data from a pharmacokinetics assay.", @@ -2088,5 +6968,423 @@ "resourceType" ], "title": "PharmacokineticsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/PlateBasedReporterAssayTemplate.json b/registered-json-schemas/PlateBasedReporterAssayTemplate.json index 8a57b5fc..f9835298 100644 --- a/registered-json-schemas/PlateBasedReporterAssayTemplate.json +++ b/registered-json-schemas/PlateBasedReporterAssayTemplate.json @@ -73,13 +73,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Generic template for describing data from a plate-based reporter assay.", "properties": { "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "specimenID": { @@ -89,7 +1124,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "platform": { @@ -106,7 +1144,10 @@ }, "assayTarget": { "description": "Target of the assay such as a HUGO gene symbol, cell type, or tissue region depending on the capabilities of the assay.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "assayTarget" }, "compoundName": { @@ -126,12 +1167,18 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "experimentalTimepoint": { "description": "The numeric value indicating the time elapsed from the beginning of the experiment at which the specimen was collected. Use in tandem with timePointUnit", - "type": "number", + "type": [ + "number", + "null" + ], "title": "experimentalTimepoint" }, "timepointUnit": { @@ -150,17 +1197,26 @@ }, "reporterGene": { "description": "A gene which produces an easily assayed phenotype. Often used for expression studies of heterologous promoters.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "reporterGene" }, "reporterSubstance": { "description": "A biological material (clone, oligo, etc.) on an array which will report on some biosequence or biosequences.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "reporterSubstance" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -363,6 +1419,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -448,9 +1507,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -691,6 +1782,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -707,7 +1801,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -725,14 +1822,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -758,63 +1879,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -868,13 +2036,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -887,32 +2048,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -925,134 +2061,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1068,8 +2167,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1237,52 +2334,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1351,51 +2414,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1428,98 +2549,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1529,27 +2651,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1569,31 +2690,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1643,14 +2812,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1743,9 +2936,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "PlateBasedReporterAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/PortalDataset.json b/registered-json-schemas/PortalDataset.json index baaefadc..54bd0262 100644 --- a/registered-json-schemas/PortalDataset.json +++ b/registered-json-schemas/PortalDataset.json @@ -27,22 +27,34 @@ "title": "HumanAgeGroupEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "ageGroup" }, "alternateName": { "description": "An altername name that can be used for search and discovery improvement.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "alternateName" }, "citation": { "description": "Academic articles that are recommended by the data provider to be cited in addition to the dataset doi itself.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "citation" }, "conditionsOfAccess": { "description": "Additional requirements a user may need outside of Data Use Modifiers. This could include additional registration, updating profile information, joining a Synapse Team, or using specific authentication methods like 2FA or RAS. Omit property if not applicable/unknown.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "conditionsOfAccess" }, "contributor": { @@ -50,7 +62,10 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "contributor" }, "countryOfOrigin": { @@ -58,7 +73,10 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "countryOfOrigin" }, "creator": { @@ -71,7 +89,10 @@ }, "croissant_file_s3_object": { "description": "Link to croissant file for dataset.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "croissant_file_s3_object" }, "dataType": { @@ -176,17 +197,26 @@ "title": "DuoEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "dataUseModifiers" }, "datePublished": { "description": "Date data were published/available on Synapse. This can be set automatically from other dates tracked in Synapse system so does not need to be manually added.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "datePublished" }, "description": { "description": "Blurb for the dataset; should be no more than 500 characters.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "description" }, "diseaseFocus": { @@ -211,12 +241,18 @@ "doi": { "description": "The Digital Object Identifier (DOI) of the dataset (if one has been created), used for citation and persistent identification.", "pattern": "^10\\\\.\\\\d{4,9}/[-._;()/:A-Z0-9]+$", - "type": "string", + "type": [ + "string", + "null" + ], "title": "doi" }, "externalRepositoryUri": { "description": "Reference to dataset in an external repository using CURIE-style format, e.g. zenodo:12345678.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "externalRepositoryUri" }, "funder": { @@ -247,12 +283,18 @@ "title": "DataCatalogEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "includedInDataCatalog" }, "individualCount": { "description": "Number of unique individuals included in the dataset (whether as individual-level or as aggregate data). Omit if not applicable/unknown.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "individualCount" }, "keywords": { @@ -260,7 +302,10 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "keywords" }, "license": { @@ -344,7 +389,10 @@ "title": "ManifestationEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "manifestation" }, "measurementTechnique": { @@ -557,7 +605,10 @@ ], "description": "Sequencing-based assays including RNA-seq, DNA-seq, and related methods" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "measurementTechnique" }, "series": { @@ -589,12 +640,18 @@ "title": "SpeciesEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "species" }, "specimenCount": { "description": "Number of unique specimens included in the dataset. Omit if not applicable/unknown.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "specimenCount" }, "studyId": { @@ -607,7 +664,10 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "subject" }, "title": { @@ -619,12 +679,18 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "visualizeDataOn" }, "yearProcessed": { "description": "Year data were processed. Only for processed data types and when data series is \"NF-OSI Processed Data\"; omit if not applicable/unknown.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "yearProcessed" } }, diff --git a/registered-json-schemas/PortalPublication.json b/registered-json-schemas/PortalPublication.json index efb5541a..0dfe1c68 100644 --- a/registered-json-schemas/PortalPublication.json +++ b/registered-json-schemas/PortalPublication.json @@ -19,7 +19,10 @@ "title": "DiseaseFocusEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "diseaseFocus" }, "fundingAgency": { @@ -30,7 +33,10 @@ "title": "fundingAgency" }, "manifestation": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "manifestation" }, "publicationType": { diff --git a/registered-json-schemas/PortalStudy.json b/registered-json-schemas/PortalStudy.json index 81e151c4..97022172 100644 --- a/registered-json-schemas/PortalStudy.json +++ b/registered-json-schemas/PortalStudy.json @@ -4,24 +4,39 @@ "description": "A scientific project of some planned duration with PIs and key contributors, specific research topics, and potential publication/data/other outputs. A study is often represented as a Synapse project and so is also referred to as \"project\". The study schema here is specifically for studies listed on the NF Portal at https://nf.synapse.org/Explore/Studies.", "properties": { "accessRequirements": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "accessRequirements" }, "acknowledgementStatements": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "acknowledgementStatements" }, "externalRepositoryUri": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "externalRepositoryUri" }, "clinicalTrialID": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "clinicalTrialID" }, "dataCoordinatingCenter": { "description": "The organization or center responsible for coordinating data management and sharing for this study. Defaults to \"NF-OSI\".", - "type": "string", + "type": [ + "string", + "null" + ], "title": "dataCoordinatingCenter" }, "dataStatus": { @@ -103,7 +118,10 @@ "title": "Data", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "dataType" }, "diseaseFocus": { @@ -122,11 +140,17 @@ "title": "DiseaseFocusEnum", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "diseaseFocus" }, "embargoEndDate": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "embargoEndDate" }, "fundingAgency": { @@ -137,15 +161,24 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "grantDOI" }, "grantEndDate": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "grantEndDate" }, "grantStartDate": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "grantStartDate" }, "initiative": { @@ -498,28 +531,43 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "manifestation" }, "nextPhaseProject": { "description": "Synapse project ID of a follow-up project that represents a subsequent funding phase, extension, or continuation of this study's research effort.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "nextPhaseProject" }, "previousPhaseProject": { "description": "Synapse project ID of the previous project that this study continues or extends, typically representing an earlier funding phase of the same research effort.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "previousPhaseProject" }, "relatedStudies": { "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "relatedStudies" }, "releasedDate": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "releasedDate" }, "studyFileviewId": { diff --git a/registered-json-schemas/ProcessedAlignedReadsTemplate.json b/registered-json-schemas/ProcessedAlignedReadsTemplate.json index 5b90bac8..3d443df4 100644 --- a/registered-json-schemas/ProcessedAlignedReadsTemplate.json +++ b/registered-json-schemas/ProcessedAlignedReadsTemplate.json @@ -73,6 +73,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing aligned reads (e.g. BAM/CRAM files) from a sequencing assay. The QC meta are extracted from samtools stats when available and are the same metrics preferred by GDC.", @@ -94,62 +1126,98 @@ }, "genomicReferenceLink": { "description": "Link to genome reference data file used for alignment in processing workflow", - "type": "string", + "type": [ + "string", + "null" + ], "title": "genomicReferenceLink" }, "averageInsertSize": { "description": "Average insert size as reported by samtools", - "type": "string", + "type": [ + "string", + "null" + ], "title": "averageInsertSize" }, "averageReadLength": { "description": "Average read length collected from samtools", - "type": "string", + "type": [ + "string", + "null" + ], "title": "averageReadLength" }, "averageBaseQuality": { "description": "Average base quality collected from samtools", - "type": "string", + "type": [ + "string", + "null" + ], "title": "averageBaseQuality" }, "pairsOnDifferentChr": { "description": "Pairs on different chromosomes collected from samtools", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "pairsOnDifferentChr" }, "readsDuplicatedPercent": { "description": "Percent of duplicated reads collected from samtools", - "type": "string", + "type": [ + "string", + "null" + ], "title": "readsDuplicatedPercent" }, "readsMappedPercent": { "description": "Percent of mapped reads collected from samtools", - "type": "number", + "type": [ + "number", + "null" + ], "title": "readsMappedPercent" }, "meanCoverage": { "description": "Mean coverage for whole genome sequencing, or mean target coverage for whole exome and targeted sequencing, collected from Picard Tools", - "type": "string", + "type": [ + "string", + "null" + ], "title": "meanCoverage" }, "proportionCoverage10x": { "description": "Proportion of all reference bases for whole genome sequencing, or targeted bases for whole exome and targeted sequencing, that achieves 10X or greater coverage from Picard Tools", - "type": "number", + "type": [ + "number", + "null" + ], "title": "proportionCoverage10x" }, "proportionCoverage30x": { "description": "Proportion of all reference bases for whole genome sequencing, or targeted bases for whole exome and targeted sequencing, that achieves 30X or greater coverage from Picard Tools", - "type": "number", + "type": [ + "number", + "null" + ], "title": "proportionCoverage30x" }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "totalReads": { "description": "If available, the total number of reads collected from samtools.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "totalReads" }, "workflow": { @@ -175,12 +1243,18 @@ }, "workflowLink": { "description": "Workflow URL reference", - "type": "string", + "type": [ + "string", + "null" + ], "title": "workflowLink" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "specimenID": { @@ -190,7 +1264,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -393,6 +1470,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -608,9 +1688,41 @@ ], "title": "assay" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -629,6 +1741,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -820,6 +1996,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -836,7 +2015,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -854,14 +2036,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -887,63 +2093,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -997,13 +2250,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -1016,32 +2262,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -1054,134 +2275,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1197,8 +2381,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1366,52 +2548,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1480,51 +2628,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1557,98 +2763,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1658,27 +2865,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1698,31 +2904,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1772,14 +3026,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1869,9 +3147,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ProcessedAlignedReadsTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProcessedExpressionTemplate.json b/registered-json-schemas/ProcessedExpressionTemplate.json index fa259be0..e804e987 100644 --- a/registered-json-schemas/ProcessedExpressionTemplate.json +++ b/registered-json-schemas/ProcessedExpressionTemplate.json @@ -55,6 +55,4886 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for quantified gene/protein expression data that are still represented as one file per sample.", @@ -1933,5 +6813,423 @@ "resourceType" ], "title": "ProcessedExpressionTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProcessedGeneExpressionTemplate.json b/registered-json-schemas/ProcessedGeneExpressionTemplate.json index 93596f98..971b6758 100644 --- a/registered-json-schemas/ProcessedGeneExpressionTemplate.json +++ b/registered-json-schemas/ProcessedGeneExpressionTemplate.json @@ -55,6 +55,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for quantified gene/protein expression data that are still represented as one file per sample.", @@ -96,12 +1128,18 @@ }, "workflowLink": { "description": "Workflow URL reference", - "type": "string", + "type": [ + "string", + "null" + ], "title": "workflowLink" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "specimenID": { @@ -111,7 +1149,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -314,6 +1355,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -529,9 +1573,41 @@ ], "title": "assay" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -885,6 +1961,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -901,7 +1980,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -919,14 +2001,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -952,63 +2058,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -1062,13 +2215,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -1081,32 +2227,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -1119,134 +2240,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1262,8 +2346,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1431,52 +2513,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1545,51 +2593,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1622,98 +2728,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1723,27 +2830,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1763,31 +2869,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1837,14 +2991,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1933,9 +3111,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ProcessedGeneExpressionTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProcessedMergedDataTemplate.json b/registered-json-schemas/ProcessedMergedDataTemplate.json index 9efd3372..b444f2fc 100644 --- a/registered-json-schemas/ProcessedMergedDataTemplate.json +++ b/registered-json-schemas/ProcessedMergedDataTemplate.json @@ -116,12 +116,18 @@ }, "workflowLink": { "description": "Workflow URL reference", - "type": "string", + "type": [ + "string", + "null" + ], "title": "workflowLink" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "assay": { diff --git a/registered-json-schemas/ProcessedVariantCallsTemplate.json b/registered-json-schemas/ProcessedVariantCallsTemplate.json index 5ff1266b..744dc7d3 100644 --- a/registered-json-schemas/ProcessedVariantCallsTemplate.json +++ b/registered-json-schemas/ProcessedVariantCallsTemplate.json @@ -55,13 +55,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing either simple germline/somatic variant calls output data (VCF/MAF) as well as structural variants (e.g. CNVs).", "properties": { "isFilteredReads": { "description": "Whether the reads in the processed result has been filtered by adding a 'PASS' filter or other filters as determined by the data generator", - "type": "string", + "type": [ + "string", + "null" + ], "title": "isFilteredReads" }, "workflow": { @@ -87,12 +1122,18 @@ }, "workflowLink": { "description": "Workflow URL reference", - "type": "string", + "type": [ + "string", + "null" + ], "title": "workflowLink" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "specimenID": { @@ -102,7 +1143,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -305,6 +1349,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -520,9 +1567,41 @@ ], "title": "assay" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -796,6 +1875,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -812,7 +1894,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -830,14 +1915,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -863,63 +1972,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -973,13 +2129,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -992,32 +2141,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -1030,134 +2154,97 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", "MPNST-91", "MPNST-92", "MUG-Mel1", - "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone C8", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1173,8 +2260,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1342,52 +2427,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1456,51 +2507,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1533,98 +2642,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1634,27 +2744,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1674,31 +2783,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1748,14 +2905,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1844,9 +3025,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ProcessedVariantCallsTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProteinArrayTemplate.json b/registered-json-schemas/ProteinArrayTemplate.json index 5400bb6d..340cf4c7 100644 --- a/registered-json-schemas/ProteinArrayTemplate.json +++ b/registered-json-schemas/ProteinArrayTemplate.json @@ -37,6 +37,4886 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for array- and immuno-based proteomics data.", @@ -1625,5 +6505,423 @@ "resourceType" ], "title": "ProteinArrayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProteinInteractionAssayTemplate.json b/registered-json-schemas/ProteinInteractionAssayTemplate.json index 1cd24678..b0c39085 100644 --- a/registered-json-schemas/ProteinInteractionAssayTemplate.json +++ b/registered-json-schemas/ProteinInteractionAssayTemplate.json @@ -37,38 +37,1088 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for datasets reporting protein-protein interaction measurements such as affinity purification mass spectrometry, BioID proximity labeling, or yeast two-hybrid screens.", "properties": { "baitProtein": { "description": "Protein identifier or name of the bait used for interaction detection experiments.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "baitProtein" }, "baitGene": { "description": "Gene symbol associated with the bait protein.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "baitGene" }, "interactionDetectionMethod": { "description": "Method or platform used to detect protein interactions (e.g., AP-MS, BioID, yeast two-hybrid).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "interactionDetectionMethod" }, "interactionScore": { "description": "Quantitative confidence or interaction score reported for the protein interaction (e.g., SAINT score, % control).", - "type": "number", + "type": [ + "number", + "null" + ], "title": "interactionScore" }, "interactionScoreType": { "description": "Label describing the scoring metric used for the interaction measurement.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "interactionScoreType" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -87,7 +1137,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -276,6 +1329,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -303,9 +1359,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -544,6 +1632,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -560,7 +1651,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -578,14 +1672,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -611,63 +1729,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -721,13 +1886,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -740,32 +1898,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -778,40 +1911,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -819,93 +1978,30 @@ "MPNST-92", "MUG-Mel1", "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -921,8 +2017,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1090,52 +2184,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1204,51 +2264,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1281,98 +2399,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1382,27 +2501,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1422,31 +2540,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1482,7 +2648,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1522,14 +2691,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1624,9 +2817,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ProteinInteractionAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProteomicsAssayTemplate.json b/registered-json-schemas/ProteomicsAssayTemplate.json index c530b5c9..b32b6d3f 100644 --- a/registered-json-schemas/ProteomicsAssayTemplate.json +++ b/registered-json-schemas/ProteomicsAssayTemplate.json @@ -37,13 +37,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Alias to MassSpecAssayTemplate for backwards-compatibility.", "properties": { "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -62,7 +1097,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -251,6 +1289,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -278,9 +1319,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataCollectionMode": { @@ -524,6 +1597,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -540,7 +1616,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -558,14 +1637,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -591,63 +1694,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -701,13 +1851,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -720,32 +1863,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -758,40 +1876,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -799,93 +1943,30 @@ "MPNST-92", "MUG-Mel1", "MUG-Mel1 clone C8", - "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "MUG-Mel1 clone D5", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -901,8 +1982,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1070,52 +2149,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1184,51 +2229,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1261,98 +2364,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1362,27 +2466,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1402,31 +2505,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "organ": { @@ -1462,7 +2613,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1502,14 +2656,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1605,9 +2783,431 @@ "species", "diagnosis", "tumorType", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ProteomicsAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ProtocolTemplate.json b/registered-json-schemas/ProtocolTemplate.json index 45205379..626ec21f 100644 --- a/registered-json-schemas/ProtocolTemplate.json +++ b/registered-json-schemas/ProtocolTemplate.json @@ -138,12 +138,18 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "author" }, "citation": { "description": "Citation (e.g. doi) that usage of data or resource should be cited with.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "citation" }, "license": { @@ -200,227 +206,281 @@ "type": "string" }, "protocolAssay": { + "anyOf": [ + { + "description": "Sequencing-based assays including RNA-seq, DNA-seq, and related methods", + "enum": [ + "ATAC-seq", + "CAPP-seq", + "CUT&RUN", + "ChIP-seq", + "ERR bisulfite sequencing", + "HI-C", + "ISO-seq", + "NOMe-seq", + "RNA array", + "RNA-seq", + "SNP array", + "SaferSeqS", + "Sanger sequencing", + "T cell receptor repertoire sequencing", + "bisulfite sequencing", + "jumping library", + "lncRNA-seq", + "methylation array", + "miRNA array", + "miRNA-seq", + "next generation targeted sequencing", + "oxBS-seq", + "ribo-seq", + "scCGI-seq", + "single cell ATAC-seq", + "single-cell RNA-seq", + "single-nucleus RNA-seq", + "spatial transcriptomics", + "targeted exome sequencing", + "whole exome sequencing", + "whole genome sequencing" + ], + "title": "SequencingAssayEnum", + "type": "string" + }, + { + "description": "Imaging-based assays including microscopy, MRI, and related methods", + "enum": [ + "3D confocal imaging", + "3D electron microscopy", + "3D imaging", + "CODEX", + "DNA optical mapping", + "Fluorescence In Situ Hybridization", + "Magnetization-Prepared Rapid Gradient Echo MRI", + "SUSHI", + "atomic force microscopy", + "autoradiography", + "brightfield microscopy", + "live imaging", + "histology", + "confocal microscopy", + "conventional MRI", + "diffusion MRI", + "fluorescence microscopy assay", + "functional MRI", + "high frequency ultrasound", + "immunocytochemistry", + "immunofluorescence", + "immunohistochemistry", + "in vivo bioluminescence", + "laser speckle imaging", + "magnetic resonance angiography", + "magnetic resonance spectroscopy", + "optical coherence tomography", + "optical tomography", + "phase-contrast microscopy", + "photograph", + "positron emission tomography", + "spatial frequency domain imaging", + "traction force microscopy", + "transcranial doppler ultrasonography" + ], + "title": "ImagingAssayEnum", + "type": "string" + }, + { + "description": "Mass spectrometry-based assays", + "enum": [ + "FIA-MSMS", + "FTIR spectroscopy", + "MIB/MS", + "MudPIT", + "RPPA", + "TMT quantitation", + "high-performance liquid chromatography/tandem mass spectrometry", + "label free mass spectrometry", + "liquid chromatography-electrochemical detection", + "liquid chromatography/mass spectrometry", + "liquid chromatography/tandem mass spectrometry", + "mass spectrometry", + "proximity extension assay", + "ultra high-performance liquid chromatography/tandem mass spectrometry" + ], + "title": "MassSpectrometryAssayEnum", + "type": "string" + }, + { + "description": "Clinical assessments and behavioral assays", + "enum": [ + "AlgometRx Nociometer", + "quantitative sensory testing", + "Child Behavior Checklist for Ages 1.5-5", + "Child Behavior Checklist for Ages 6-18", + "Children's Dermatology Life Quality Index Questionnaire", + "Corsi blocks", + "FACE-Q Appearance-related Distress", + "Focus group", + "Interview", + "NIH Toolbox", + "PROMIS Cognitive Function", + "Riccardi and Ablon scales", + "Skindex-16", + "Social Responsiveness Scale", + "Social Responsiveness Scale, Second Edition", + "Von Frey test", + "actigraphy", + "active avoidance learning behavior assay", + "auditory brainstem response", + "blood chemistry measurement", + "body size trait measurement", + "cNF-Skindex", + "clinical data", + "cognitive assessment", + "contextual conditioning behavior assay", + "distortion product otoacoustic emissions", + "elevated plus maze test", + "feeding assay", + "gait measurement", + "genotyping", + "grip strength", + "hand-held dynamometry", + "metabolic screening", + "n-back task", + "neuropsychological assessment", + "novelty response behavior assay", + "open field test", + "optokinetic reflex assay", + "pattern electroretinogram", + "polysomnography", + "pure tone average", + "questionnaire", + "rotarod performance test", + "scale", + "six-minute walk test", + "weight", + "word recognition score" + ], + "title": "ClinicalBehavioralAssayEnum", + "type": "string" + }, + { + "description": "Cell-based assays including viability, proliferation, and functional assays", + "enum": [ + "2D AlamarBlue absorbance", + "2D AlamarBlue fluorescence", + "3D microtissue viability", + "ATPase activity assay", + "BrdU proliferation assay", + "ELISA", + "EdU proliferation assay", + "FLIPR high-throughput cellular screening", + "HPLC", + "Migration Assay", + "STR profile", + "TIDE", + "TriKinetics activity monitoring", + "array", + "blue native PAGE", + "SDS-PAGE", + "bone histomorphometry", + "cAMP-Glo Max Assay", + "calcium retention capacity assay", + "cell competition", + "cell count", + "cell painting", + "cell permeability assay", + "cell proliferation", + "cell viability assay", + "combination library screen", + "combination screen", + "complex II enzyme activity assay", + "compound screen", + "current clamp assay", + "differential scanning calorimetry", + "dynamic light scattering", + "electrochemiluminescence", + "electrophoretic light scattering", + "flow cytometry", + "focus forming assay", + "gel filtration chromatography", + "gel permeation chromatography", + "high content screen", + "immunoassay", + "in silico synthesis", + "in vitro tumorigenesis", + "in vivo PDX viability", + "in vivo tumor growth", + "light scattering assay", + "local field potential recording", + "long term potentiation assay", + "massively parallel reporter assay", + "microrheology", + "multi-electrode array", + "nanoparticle tracking analysis", + "oscillatory rheology", + "oxygen consumption assay", + "perineurial cell thickness", + "pharmocokinetic ADME assay", + "polymerase chain reaction", + "quantitative PCR", + "reactive oxygen species assay", + "reporter gene assay", + "split-GFP assay", + "rheometry", + "sandwich ELISA", + "single molecule drug screen assay", + "small molecule library screen", + "sorbitol dehydrogenase activity level assay", + "static histomorphometry", + "static light scattering", + "survival", + "trans-endothelial electrical resistance", + "twin spot assay", + "western blot", + "whole-cell patch clamp" + ], + "title": "CellBasedAssayEnum", + "type": "string" + }, + { + "description": "Drug screening assays - subset of cell-based assays focused on drug discovery", + "enum": [ + "combination library screen", + "combination screen", + "single molecule drug screen assay", + "small molecule library screen" + ], + "title": "DrugScreenAssayEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Main assay type that this protocol is related to, e.g. this is a prep protocol for single-cell RNA-seq assay. This is especially helpful for newly-developed or in-house assays.\n", "type": "string", - "enum": [ - "ATAC-seq", - "CAPP-seq", - "CUT&RUN", - "ChIP-seq", - "ERR bisulfite sequencing", - "HI-C", - "ISO-seq", - "NOMe-seq", - "RNA array", - "RNA-seq", - "SNP array", - "SaferSeqS", - "Sanger sequencing", - "T cell receptor repertoire sequencing", - "bisulfite sequencing", - "jumping library", - "lncRNA-seq", - "methylation array", - "miRNA array", - "miRNA-seq", - "next generation targeted sequencing", - "oxBS-seq", - "ribo-seq", - "scCGI-seq", - "single cell ATAC-seq", - "single-cell RNA-seq", - "single-nucleus RNA-seq", - "spatial transcriptomics", - "targeted exome sequencing", - "whole exome sequencing", - "whole genome sequencing", - "3D confocal imaging", - "3D electron microscopy", - "3D imaging", - "CODEX", - "DNA optical mapping", - "Fluorescence In Situ Hybridization", - "Magnetization-Prepared Rapid Gradient Echo MRI", - "SUSHI", - "atomic force microscopy", - "autoradiography", - "brightfield microscopy", - "live imaging", - "histology", - "confocal microscopy", - "conventional MRI", - "diffusion MRI", - "fluorescence microscopy assay", - "functional MRI", - "high frequency ultrasound", - "immunocytochemistry", - "immunofluorescence", - "immunohistochemistry", - "in vivo bioluminescence", - "laser speckle imaging", - "magnetic resonance angiography", - "magnetic resonance spectroscopy", - "optical coherence tomography", - "optical tomography", - "phase-contrast microscopy", - "photograph", - "positron emission tomography", - "spatial frequency domain imaging", - "traction force microscopy", - "transcranial doppler ultrasonography", - "FIA-MSMS", - "FTIR spectroscopy", - "MIB/MS", - "MudPIT", - "RPPA", - "TMT quantitation", - "high-performance liquid chromatography/tandem mass spectrometry", - "label free mass spectrometry", - "liquid chromatography-electrochemical detection", - "liquid chromatography/mass spectrometry", - "liquid chromatography/tandem mass spectrometry", - "mass spectrometry", - "proximity extension assay", - "ultra high-performance liquid chromatography/tandem mass spectrometry", - "AlgometRx Nociometer", - "quantitative sensory testing", - "Child Behavior Checklist for Ages 1.5-5", - "Child Behavior Checklist for Ages 6-18", - "Children's Dermatology Life Quality Index Questionnaire", - "Corsi blocks", - "FACE-Q Appearance-related Distress", - "Focus group", - "Interview", - "NIH Toolbox", - "PROMIS Cognitive Function", - "Riccardi and Ablon scales", - "Skindex-16", - "Social Responsiveness Scale", - "Social Responsiveness Scale, Second Edition", - "Von Frey test", - "actigraphy", - "active avoidance learning behavior assay", - "auditory brainstem response", - "blood chemistry measurement", - "body size trait measurement", - "cNF-Skindex", - "clinical data", - "cognitive assessment", - "contextual conditioning behavior assay", - "distortion product otoacoustic emissions", - "elevated plus maze test", - "feeding assay", - "gait measurement", - "genotyping", - "grip strength", - "hand-held dynamometry", - "metabolic screening", - "n-back task", - "neuropsychological assessment", - "novelty response behavior assay", - "open field test", - "optokinetic reflex assay", - "pattern electroretinogram", - "polysomnography", - "pure tone average", - "questionnaire", - "rotarod performance test", - "scale", - "six-minute walk test", - "weight", - "word recognition score", - "2D AlamarBlue absorbance", - "2D AlamarBlue fluorescence", - "3D microtissue viability", - "ATPase activity assay", - "BrdU proliferation assay", - "ELISA", - "EdU proliferation assay", - "FLIPR high-throughput cellular screening", - "HPLC", - "Migration Assay", - "STR profile", - "TIDE", - "TriKinetics activity monitoring", - "array", - "blue native PAGE", - "SDS-PAGE", - "bone histomorphometry", - "cAMP-Glo Max Assay", - "calcium retention capacity assay", - "cell competition", - "cell count", - "cell painting", - "cell permeability assay", - "cell proliferation", - "cell viability assay", - "combination library screen", - "combination screen", - "complex II enzyme activity assay", - "compound screen", - "current clamp assay", - "differential scanning calorimetry", - "dynamic light scattering", - "electrochemiluminescence", - "electrophoretic light scattering", - "flow cytometry", - "focus forming assay", - "gel filtration chromatography", - "gel permeation chromatography", - "high content screen", - "immunoassay", - "in silico synthesis", - "in vitro tumorigenesis", - "in vivo PDX viability", - "in vivo tumor growth", - "light scattering assay", - "local field potential recording", - "long term potentiation assay", - "massively parallel reporter assay", - "microrheology", - "multi-electrode array", - "nanoparticle tracking analysis", - "oscillatory rheology", - "oxygen consumption assay", - "perineurial cell thickness", - "pharmocokinetic ADME assay", - "polymerase chain reaction", - "quantitative PCR", - "reactive oxygen species assay", - "reporter gene assay", - "split-GFP assay", - "rheometry", - "sandwich ELISA", - "single molecule drug screen assay", - "small molecule library screen", - "sorbitol dehydrogenase activity level assay", - "static histomorphometry", - "static light scattering", - "survival", - "trans-endothelial electrical resistance", - "twin spot assay", - "western blot", - "whole-cell patch clamp", - "combination library screen", - "combination screen", - "single molecule drug screen assay", - "small molecule library screen" - ], "title": "protocolAssay" }, "protocolPurpose": { "description": "Brief description of the protocol purpose.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "protocolPurpose" }, "sampleType": { "description": "Type of sample used", - "type": "string", + "type": [ + "string", + "null" + ], "title": "sampleType" }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "resourceType": { diff --git a/registered-json-schemas/PublicationTemplate.json b/registered-json-schemas/PublicationTemplate.json index 56d7fd9c..ae19486e 100644 --- a/registered-json-schemas/PublicationTemplate.json +++ b/registered-json-schemas/PublicationTemplate.json @@ -28,7 +28,10 @@ "title": "doi" }, "grantNumber": { - "type": "string", + "type": [ + "string", + "null" + ], "title": "grantNumber" }, "journal": { diff --git a/registered-json-schemas/RNASeqTemplate.json b/registered-json-schemas/RNASeqTemplate.json index 9b3ea5de..5cfc35fe 100644 --- a/registered-json-schemas/RNASeqTemplate.json +++ b/registered-json-schemas/RNASeqTemplate.json @@ -73,13 +73,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing raw data from (bulk) RNA-sequencing", "properties": { "genePerturbed": { "description": "The HUGO gene symbol for the gene that is perturbed.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "genePerturbed" }, "genePerturbationType": { @@ -105,7 +1140,10 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "isCellLine": { @@ -128,7 +1166,10 @@ }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -147,7 +1188,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -336,6 +1380,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -382,12 +1429,47 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -406,6 +1488,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -597,6 +1743,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -664,7 +1813,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -682,14 +1834,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -715,63 +1891,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -825,13 +2048,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -844,32 +2060,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -882,40 +2073,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -924,92 +2141,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1025,8 +2179,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1194,52 +2346,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1308,51 +2426,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1385,98 +2561,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1486,27 +2663,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1526,31 +2702,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1598,7 +2822,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1633,19 +2860,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1673,14 +2909,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1723,44 +2983,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1835,9 +3115,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "RNASeqTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ReferenceSequenceTemplate.json b/registered-json-schemas/ReferenceSequenceTemplate.json index b3435532..366a7a67 100644 --- a/registered-json-schemas/ReferenceSequenceTemplate.json +++ b/registered-json-schemas/ReferenceSequenceTemplate.json @@ -74,12 +74,18 @@ }, "sequenceName": { "description": "Descriptive name or identifier for the nucleotide or amino acid sequence.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "sequenceName" }, "sequenceLength": { "description": "Length of the sequence in nucleotides or amino acids.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "sequenceLength" }, "species": { @@ -102,7 +108,10 @@ }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "fileFormat": { diff --git a/registered-json-schemas/ScRNASeqTemplate.json b/registered-json-schemas/ScRNASeqTemplate.json index 2c78120c..54245830 100644 --- a/registered-json-schemas/ScRNASeqTemplate.json +++ b/registered-json-schemas/ScRNASeqTemplate.json @@ -73,13 +73,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing raw data from single-cell RNA-seq.", "properties": { "genePerturbed": { "description": "The HUGO gene symbol for the gene that is perturbed.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "genePerturbed" }, "genePerturbationType": { @@ -105,12 +1140,18 @@ }, "experimentalCondition": { "description": "A free-text description of the experimental condition (e.g. 5 mM doxorubicin).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "experimentalCondition" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -129,7 +1170,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -318,6 +1362,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -364,19 +1411,57 @@ }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, "cellID": { "description": "Also known as cell barcode, this value can be added for single-cell experiments to identify data at the cell level.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "cellID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "cellType": { "description": "A cell type is a distinct morphological or functional form of cell.", "items": { @@ -421,12 +1506,18 @@ "title": "Cell", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "cellType" }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -445,6 +1536,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -651,6 +1806,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -732,7 +1890,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -750,14 +1911,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -783,63 +1968,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", - "28cNF", - "2XSB", - "3PNF_FiPSsv_PM_2", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", + "28cNF", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", + "3PNF_FiPSsv_PM_2", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -893,13 +2125,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -912,32 +2137,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -950,40 +2150,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -992,92 +2218,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1093,8 +2256,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1262,52 +2423,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1376,51 +2503,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1453,98 +2638,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", - "MPNST-Nf1-001", - "MPNST-Nf1-002", - "MPNST-Nf1-S462", - "MPNST-SP-001", - "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", + "MPNST-Nf1-001", + "MPNST-Nf1-002", + "MPNST-Nf1-S462", + "MPNST-SP-001", + "MPSNT-SP-002", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1554,27 +2740,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1594,31 +2779,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1666,7 +2899,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1701,19 +2937,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1741,14 +2986,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1792,7 +3061,10 @@ }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1868,9 +3140,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ScRNASeqTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/ScSequencingAssayTemplate.json b/registered-json-schemas/ScSequencingAssayTemplate.json index 2e432364..8e4a7cd3 100644 --- a/registered-json-schemas/ScSequencingAssayTemplate.json +++ b/registered-json-schemas/ScSequencingAssayTemplate.json @@ -37,6 +37,1038 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "General template for raw RNA/DNA data, i.e. sequence data from a sequencing assay.", @@ -85,7 +1117,10 @@ "title": "Cell", "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "cellType" }, "isCellLine": { @@ -99,7 +1134,10 @@ }, "cellID": { "description": "Also known as cell barcode, this value can be added for single-cell experiments to identify data at the cell level.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "cellID" }, "dissociationMethod": { @@ -186,37 +1224,58 @@ "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, "auxiliaryAsset": { "description": "URI to supplemental asset(s), e.g. QC reports or other auxiliary files to support the processing, analysis, or interpretation of the current entity.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "auxiliaryAsset" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -235,7 +1294,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -424,6 +1486,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -468,9 +1533,41 @@ "title": "assay", "type": "string" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -744,6 +1841,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -760,7 +1860,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -778,14 +1881,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -811,63 +1938,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", - "5PNF_TDiPSsv_MM_4", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", "5PNF_TDiPSsv_PM_6", - "6PNF_SiPSrv_PM_2", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", + "5PNF_TDiPSsv_MM_4", + "cNF98.4c", + "6PNF_SiPSrv_PM_2", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -921,13 +2095,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -940,32 +2107,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -978,40 +2120,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -1020,92 +2188,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", - "N206", - "NB90-4", - "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", - "NCI-H1651", - "NCI-H1792", - "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", + "N206", + "NB90-4", + "NB90-6", + "NCI-H1651", + "NCI-H1838", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", "NZM022", "NZM041", "NZM047", "NZM072", "NZM077", "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", "OSW", "PEO4", "PEO4-iPSC-OSKM-03", "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", "PNET-1", "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -1121,8 +2226,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1290,52 +2393,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1404,51 +2473,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1481,98 +2608,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1582,27 +2710,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1622,31 +2749,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1694,7 +2869,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1743,14 +2921,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1865,9 +3067,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "ScSequencingAssayTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/SourceCodeTemplate.json b/registered-json-schemas/SourceCodeTemplate.json index 62e7045c..2454447a 100644 --- a/registered-json-schemas/SourceCodeTemplate.json +++ b/registered-json-schemas/SourceCodeTemplate.json @@ -13,12 +13,18 @@ "items": { "type": "string" }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "author" }, "citation": { "description": "Citation (e.g. doi) that usage of data or resource should be cited with.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "citation" }, "license": { @@ -76,17 +82,26 @@ }, "programmingLanguage": { "description": "A computer programming language", - "type": "string", + "type": [ + "string", + "null" + ], "title": "programmingLanguage" }, "runtimePlatform": { "description": "Runtime platform or script interpreter dependencies (e.g. Java v1, Python 2.3).", - "type": "string", + "type": [ + "string", + "null" + ], "title": "runtimePlatform" }, "documentation": { "description": "URL to any documentation describing the resource and its use.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "documentation" }, "resourceType": { diff --git a/registered-json-schemas/UpdateMilestoneReport.json b/registered-json-schemas/UpdateMilestoneReport.json index 76576555..03350661 100644 --- a/registered-json-schemas/UpdateMilestoneReport.json +++ b/registered-json-schemas/UpdateMilestoneReport.json @@ -20,7 +20,10 @@ }, "progressReportNumber": { "description": "Indicates milestone the data is associated with. Currently only required for projects funded by NTAP, GFF, and NFRI. For GFF studies, this is the \u2018progress report\u2019 timeline. Example: if submitting data for the 6-month milestone report for NTAP, progressReportNumber=1. Also if submitting data associated with first milestone, progressReportNumber =1", - "type": "string", + "type": [ + "string", + "null" + ], "title": "progressReportNumber" } }, diff --git a/registered-json-schemas/WESTemplate.json b/registered-json-schemas/WESTemplate.json index d9b5c20c..4f815dd1 100644 --- a/registered-json-schemas/WESTemplate.json +++ b/registered-json-schemas/WESTemplate.json @@ -37,18 +37,1056 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing raw data from Whole Exome Sequencing (WES/WXS)", "properties": { "targetCaptureKitID": { "description": "A unique identifier for the kit used to construct a genomic library using target capture-based techniques, which should be composed of the vendor name, kit name and kit version.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetCaptureKitID" }, "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -67,7 +1105,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -256,6 +1297,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -302,12 +1346,47 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -326,6 +1405,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -517,6 +1660,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -584,7 +1730,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -602,14 +1751,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -635,63 +1808,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -745,13 +1965,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -764,32 +1977,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -802,40 +1990,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -844,92 +2058,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -945,8 +2096,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1114,52 +2263,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1228,51 +2343,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1305,98 +2478,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1406,27 +2580,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1446,31 +2619,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1518,7 +2739,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1553,19 +2777,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1593,14 +2826,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1643,44 +2900,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1755,9 +3032,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "WESTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/WGSTemplate.json b/registered-json-schemas/WGSTemplate.json index 8da5deac..cccc8774 100644 --- a/registered-json-schemas/WGSTemplate.json +++ b/registered-json-schemas/WGSTemplate.json @@ -37,13 +37,1048 @@ "dataSubtype" ] } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosistype 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Transformed cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Telomerase immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Finite cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Homo sapiens" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Embryonic stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Induced pluripotent stem cell" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Hybridoma" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Mus musculus" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "Neurofibromatosis type 1" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Canis lupus familiaris" + }, + "cellLineCategory": { + "const": "Cancer cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Xenopus laevis" + }, + "cellLineCategory": { + "const": "Spontaneously immortalized cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Escherichia coli" + }, + "cellLineCategory": { + "const": "Undefined cell line type" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "cell line" + }, + "modelSpecies": { + "const": "Cricetulus griseus" + }, + "cellLineCategory": { + "const": "Hybrid cell line" + }, + "cellLineGeneticDisorder": { + "const": "No known genetic disorder" + } + }, + "required": [ + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Danio rerio" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDaniorerioNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Drosophila melanogaster" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Sus scrofa" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSusscrofaNeurofibromatosistype1Enum" + } + } + } + } + }, + { + "if": { + "properties": { + "modelSystemType": { + "const": "animal model" + }, + "modelSpecies": { + "const": "Saccharomyces cerevisiae" + } + }, + "required": [ + "modelSystemType", + "modelSpecies" + ] + }, + "then": { + "properties": { + "modelSystemName": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + }, + "individualID": { + "items": { + "$ref": "#/$defs/AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + } + } + } + } } ], "description": "Template for describing raw data from Whole Genome Sequencing (WGS)", "properties": { "age": { "description": "A numeric value representing age of the individual. Use with `ageUnit`.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "age" }, "ageUnit": { @@ -62,7 +1097,10 @@ }, "aliquotID": { "description": "A unique identifier (non-PII) that represents the aliquots used for e.g. replicate runs. This is linked to the specimenID.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "aliquotID" }, "antibodyID": { @@ -251,6 +1289,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Antibody identifier. Select from the controlled vocabulary of antibodies in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to antibody details are available in the schema see_also field for enum values.", @@ -297,12 +1338,47 @@ }, "batchID": { "description": "Batch identifier, can be used in any context where added batch information is helpful, such as different sequencing runs or collection times.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "batchID" }, + "cellLineCategory": { + "description": "Category of cell line based on origin and characteristics", + "enum": [ + "Cancer cell line", + "Induced pluripotent stem cell", + "Transformed cell line", + "Telomerase immortalized cell line", + "Embryonic stem cell", + "Finite cell line", + "Hybrid cell line", + "Hybridoma", + "Spontaneously immortalized cell line", + "Undefined cell line type" + ], + "title": "cellLineCategory", + "type": "string" + }, + "cellLineGeneticDisorder": { + "description": "Genetic disorder associated with the cell line", + "enum": [ + "Neurofibromatosis type 1", + "Neurofibromatosis type 2", + "Schwannomatosis", + "Noonan Syndrome", + "No known genetic disorder" + ], + "title": "cellLineGeneticDisorder", + "type": "string" + }, "comments": { "description": "Brief free-text comments that may also be important to understanding the resource.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "comments" }, "dataSubtype": { @@ -321,6 +1397,70 @@ "dataType": { "description": "Links an entity to data types that the entity represents/contains. This is closely tied to the assay property. For example, a file of dataType `genomicVariants` might have an assay value of `whole genome sequencing`.\n", "type": "string", + "enum": [ + "aligned reads", + "annotated germline variants", + "annotated somatic mutation", + "audio transcript", + "behavioral data", + "capsid sequence", + "cellular physiology", + "characteristic", + "chromatin activity", + "clinical", + "copy number variants", + "count matrix", + "data index", + "data sharing plan", + "demographics", + "drug combination screen", + "drug screen", + "electrophysiology", + "epidemiological data", + "gene expression", + "gene expression matrix", + "quantified gene expression", + "genomic features", + "genomic variants", + "germline variants", + "guide RNA sequence", + "image", + "immunoassay", + "isoform expression", + "kinomics", + "mask image", + "mass spectrometry data", + "metabolomics", + "molecular property", + "morphology parameter", + "network", + "nucleic acid sequence record", + "over-representation data", + "particle characterization", + "pharmacokinetics", + "physiology parameter", + "plasmid sequence", + "plot", + "primer sequence", + "probe sequence", + "promoter sequence", + "protein interaction data", + "protein interaction raw data", + "proteomics", + "raw counts", + "reference sequence", + "report", + "somatic variants", + "structural variants", + "survey data", + "text data", + "volume", + "weight", + "descriptive metadata", + "image metadata", + "metadata", + "workflow metadata" + ], "title": "dataType" }, "diagnosis": { @@ -512,6 +1652,9 @@ }, { "type": "string" + }, + { + "type": "null" } ], "description": "Identifier for genetic reagent used (e.g., CRISPR construct, shRNA, plasmid). Select from the controlled vocabulary of genetic reagents in NF Research Tools Central (syn51730943) when available, or provide a custom identifier. Links to reagent details are available in the schema see_also field for enum values.", @@ -579,7 +1722,10 @@ }, "modelAge": { "description": "Age of the individual animal model at time of experiment. Distinct from donor age. Use with modelAgeUnit.", - "type": "number", + "type": [ + "number", + "null" + ], "title": "modelAge" }, "modelAgeUnit": { @@ -597,14 +1743,38 @@ "type": "string" }, "modelSex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Sex of the individual animal model used in the experiment. Distinct from donor sex.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "modelSex" }, "modelSpecies": { @@ -630,63 +1800,110 @@ "items": { "type": "string", "enum": [ - "10/9CRC1", - "10CM", - "1507.2", - "2-004", + "HEK293 NF1 -/- with R1306X mNf1 cDNA", + "SZ-NF4", + "HBE135-E6E7", + "90-8", + "WT ES", + "HEK293 NF1 -/- Exon 47 insT #14", + "hTERT SC ipn97.4", + "HEK293 NF1 -/- with R1947X mNf1 cDNA", + "Nf1-/- skin-derived precursor cells", + "KCL025", + "NF1", + "Dhh-Cre; NF1Arg681*/flox Schwann Cells", + "NCC-MPNST3-X2-C1", + "3PNF_SiPSsv_MM_11", + "ST88-14", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "HeLa SilenciX NF1", + "hTERT NF1 ipnNF95.11c", + "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", + "HEK293 NF1 -/- with R681X mNf1 cDNA", + "SZ-NF1", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 ipn06.2 A", + "HEK293 NF1 -/- with R461X mNf1 cDNA", + "Nf1-/- HEK 293", + "icNF98.4c", + "Nf1Arg681*/Arg681* MEFs", + "GM23338", + "iPSC NF1 WT", + "sNF94.3", + "hTERT NF1 ipNF05.5", "28cNF", - "2XSB", + "YST-1", + "T265", + "Dh5 alpha", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES", + "icNF04.9a", + "Nf1-/- Epithelial lung cells", + "HEK293", + "HEK293 NF1 -/- Exon 52 R2550X #5", "3PNF_FiPSsv_PM_2", - "3PNF_SiPSsv_MM_11", - "4/30PRR", + "icNF00.10a", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "cNF98.4d", + "BJFF.6", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "5PNF_TDiPSsv_PM_6", + "NCC-MPNST2-C1", + "hTERT NF1 ipNF04.4", + "NF1-R68X Embryonic cells", + "7PNF_SiPSrv_PM_12", + "HEK293 NF1 -/- with WT tagged mNf1 cDNA", + "hTERT NF1 sipnNF95.12B", + "STS-26T", + "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", + "iPSC NF1 +/- BJFF.6 bkgd", + "GM11601", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "HEK293 NF1 -/- with R2550X mNf1 cDNA", + "hTERT NF1 ipNF95.11b C/T", + "cNF00.10a", + "iPSC Y489C; Exon 13 cryptic splice", + "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", + "S462", + "hTERT NF1 ipNF95.6", + "cNF97.2b", + "sNF02.2", + "ScienCell Schwann cells", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "S520", + "cNF04.9a", + "ELK-TAD Luciferase Reporter HEK293 Stable", + "sNF96.2", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "cNF97.2a", + "S462.TY", "5PNF_TDiPSsv_MM_4", - "5PNF_TDiPSsv_PM_6", + "cNF98.4c", "6PNF_SiPSrv_PM_2", - "7PNF_SiPSrv_PM_12", - "862L", - "9/3L", - "90-8", - "A68", - "AMC-106", - "Abcam A-549 NF1 KO", - "Abcam HCT 116 NF1 KO", - "Abcam HeLa NF1 KO", - "Abcam MCF-7 NF1 KO", - "Abcam U-87MG SNCA KO", - "AsPC-1", - "BJFF.6", - "BTSC 232", - "BTSC 233", - "BTSC 3021", - "BTSC 3047", - "BTSC 349", - "BTSC 380", - "BayGenomics ES cell line XF344", - "CFPAC-1", - "CML-6M", - "COLO 668", - "COR-L23", - "CPTC-NF1-1", - "CPTC-NF1-2", - "CPTC-NF1-3", - "CTV-1", - "Calu-1", - "Capan-1", - "Capan-2", - "D-566MG", - "DAN-G", - "DD2345", - "Dh5 alpha", - "Dhh-Cre; NF1Arg681*/flox Schwann Cells", - "ELK-TAD Luciferase Reporter HEK293 Stable", - "ELK-TAD Luciferase Reporter HEK293 Stable NF1 -/-", - "FMS-1", - "FTC-133", - "FU-SFT8710", - "GI-ME-N", - "GI-ME-NrCDDP500", - "GI-ME-NrDOX5", - "GI-ME-NrVCR14", + "KCL024", + "icNF97.2b", + "HEK293 NF1 -/- with R816X mNf1 cDNA", + "NCC-MPNST4-C1", + "hTERT NF1 ipNF03.3", + "HEK293 NF1 -/- with WT mNf1 cDNA", + "GM11602", + "HEK293 NF1 -/- clone 2", + "Schwann cell NF1 -/- with R681X mNf1 cDNA", + "HEK293 NF1 -/- with R192X mNf1 cDNA", + "NCC-MPNST1-C1", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", "GM00622", "GM01633", "GM01634", @@ -740,13 +1957,6 @@ "GM09886", "GM09887", "GM09944", - "GM10501", - "GM10502", - "GM10657", - "GM10659", - "GM11601", - "GM11602", - "GM12517", "GM21674", "GM21675", "GM21843", @@ -759,32 +1969,7 @@ "GM22608", "GM22609", "GM23312", - "GM23338", - "GP2d", - "GWH04", - "HAP1 NF1 (-) 1", - "HAP1 NF1 (-) 2", - "HAP1 NF1 (-) 3", - "HAP1 NF1 (-) 4", - "HBE135-E6E7", - "HCT 116", - "HCT 15", - "HEK293", - "HEK293 NF1 -/- Exon 17 #A15 G629R cryptic splice", - "HEK293 NF1 -/- Exon 17 #B48 G629R cryptic splice", - "HEK293 NF1 -/- Exon 47 insT #14", - "HEK293 NF1 -/- Exon 52 R2550X #5", - "HEK293 NF1 -/- clone 2", - "HEK293 NF1 -/- with R1306X mNf1 cDNA", - "HEK293 NF1 -/- with R192X mNf1 cDNA", - "HEK293 NF1 -/- with R1947X mNf1 cDNA", - "HEK293 NF1 -/- with R2550X mNf1 cDNA", - "HEK293 NF1 -/- with R461X mNf1 cDNA", - "HEK293 NF1 -/- with R681X mNf1 cDNA", - "HEK293 NF1 -/- with R816X mNf1 cDNA", - "HEK293 NF1 -/- with WT mNf1 cDNA", - "HEK293 NF1 -/- with WT tagged mNf1 cDNA", - "HPAF-II", + "DD2345", "HPS1312", "HPS1313", "HPS1314", @@ -797,40 +1982,66 @@ "HPS2253", "HPS2254", "HPS2255", - "HS-PSS", - "HS-Sch-2", - "HS53T", - "HSC1\u03bb", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "QQ0588", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6", + "1507.2", + "10/9CRC1", + "10CM", + "2XSB", + "4/30PRR", + "862L", + "9/3L", + "Abcam A-549 NF1 KO", + "Abcam HCT 116 NF1 KO", + "Abcam HeLa NF1 KO", + "Abcam MCF-7 NF1 KO", + "Abcam U-87MG SNCA KO", + "AMC-106", + "BayGenomics ES cell line XF344", + "CML-6M", + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3", + "CTV-1", + "D-566MG", + "FMS-1", + "FTC-133", + "FU-SFT8710", + "GI-ME-N", + "GI-ME-NrCDDP500", + "GI-ME-NrDOX5", + "GI-ME-NrVCR14", + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517", + "GWH04", + "HAP1 NF1 (-) 1", + "HAP1 NF1 (-) 2", + "HAP1 NF1 (-) 3", + "HAP1 NF1 (-) 4", "HTh74", "HTh74 clone 7", - "HeLa SilenciX NF1", - "HuP-T4", - "JH-2-002", - "JH-2-009", - "JH-2-031", - "KCL024", - "KCL025", - "KOMP ES cell line Nf1", - "KOMP ES cell line Nf1", - "KP-3", - "LCLC-97TM1", - "LS180", - "LS513", - "Lis42_NF1_1N", - "Lis47_NF1_2N", - "LoVo", - "Lu-65", - "Lu-99", "MCF10A_NF1_1", "MCF10A_NF1_7A1", "MCF10A_NF1_7B2", - "MCRIi020-A", - "MCRIi021-A", - "MCRIi022-A", - "MCRIi023-A", + "Mes-9", "MH/Nike", - "MIA PaCa-2", - "MPNST 724", "MPNST-14", "MPNST-642", "MPNST-90", @@ -839,92 +2050,29 @@ "MUG-Mel1", "MUG-Mel1 clone C8", "MUG-Mel1 clone D5", - "Mes-9", - "N10", "N206", "NB90-4", "NB90-6", - "NCC-MPNST1-C1", - "NCC-MPNST2-C1", - "NCC-MPNST3-C1", - "NCC-MPNST3-X2-C1", - "NCC-MPNST4-C1", - "NCC-MPNST5-C1", - "NCI-H1373", - "NCI-H1385", "NCI-H1651", - "NCI-H1792", "NCI-H1838", - "NCI-H1944", - "NCI-H2030", - "NCI-H2122", - "NCI-H23", - "NCI-H2444", - "NCI-H358", - "NCI-H441", - "NCI-H647", - "NCI-H727", - "NCI-H747", - "NF1", - "NF1+/- hiPSC-SCPs", - "NF1-/- hiPSC-SCPs", - "NF1-R68X Embryonic cells", - "NF10.1", - "NF11.1", - "NF1C-FiPS-SV4F7", - "NF1\u2010iN", "NFS-1", "NGP", "NMB", "NMS-2", "NMS-2PC", - "NMS-PC", - "NZM022", - "NZM041", - "NZM047", - "NZM072", - "NZM077", - "NZM087", - "Nf1-/- Epithelial lung cells", - "Nf1-/- HEK 293", - "Nf1-/- skin-derived precursor cells", - "Nf1Arg681*/+ ES", - "Nf1Arg681*/Arg681* ES", - "Nf1Arg681*/Arg681* MEFs", - "OSW", - "PEO4", - "PEO4-iPSC-OSKM-03", - "PEO4-iPSC-OSKM-05", - "PK-1", - "PK-45H", - "PK-59", - "PNET-1", - "PNET-2", - "PaTu 8902", - "Panc 02.03", - "Panc 03.27", - "Panc 04.03", - "Panc 08.13", - "Panc 10.05", - "QGP-1", - "QQ0588", - "RCM-1", - "RERF-LC-Ad2", - "RG-137", - "RG-138", - "RG-139", - "RG-140", - "RG-141", - "RG-235", - "RG-315", - "S462", - "S462.TY", - "S462s", - "S462sp", - "S520", + "NZM022", + "NZM041", + "NZM047", + "NZM072", + "NZM077", + "NZM087", + "OSW", + "PEO4", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05", + "PNET-1", + "PNET-2", "SHG-140", - "SHP-77", - "SIGTR ES cell line AA0320", "SJNB-1", "SJNB-10", "SJNB-12", @@ -940,8 +2088,6 @@ "SJNB-7", "SJNB-8", "SJNB-9", - "SK-CO-1", - "SK-LU-1", "SK-MEL-105", "SK-MEL-109", "SK-MEL-11", @@ -1109,52 +2255,18 @@ "SMBCi003-A", "SMBCi003-B", "SMBCi003-C", - "SNU-407", - "SNU-C2A", - "SOX10+\u00a0SLC", - "ST88-14", "ST88-3", - "STR-I-437-NF1", - "STR-I-441-NF1", - "STR-I-443-NF1", - "STS-26T", "STSA-1", - "SU.86.86", - "SW1463", - "SW1573", - "SW1990", - "SW403", - "SW480", - "SW620", - "SW837", - "SW900", - "SZ-NF1", - "SZ-NF2", - "SZ-NF4", - "SZ-NF6", - "Schwann cell NF1 -/- (iPN97.4 #24)", - "Schwann cell NF1 -/- with R681X mNf1 cDNA", - "Schwann cell NF1 -/- with R816X mNf1 cDNA", - "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", - "ScienCell Schwann cells", - "T265", "T351", - "T3M-10", - "T84", "TM-31", "TR14", "U-87MG ATCC IDH1 p.R132H", "U-87MG ATCC IDH1 p.R132H-Luc2", - "U87-NF1-419", "UCD65", "UHG-NP", - "WT ES", "WW165", - "WZJ", "XF", "XL110", - "YAPC", - "YST-1", "YUAME", "YUAVEY", "YUBEL", @@ -1223,51 +2335,109 @@ "YUZEAL", "YUZEST", "ZX2021H", + "AsPC-1", + "Calu-1", + "Capan-1", + "Capan-2", + "CFPAC-1", + "COLO 668", + "COR-L23", + "DAN-G", + "GP2d", + "HCT 116", + "HCT 15", + "HPAF-II", + "HuP-T4", + "KP-3", + "LCLC-97TM1", + "LoVo", + "LS180", + "LS513", + "Lu-65", + "Lu-99", + "MIA PaCa-2", + "NCI-H1373", + "NCI-H1385", + "NCI-H1792", + "NCI-H1944", + "NCI-H2030", + "NCI-H2122", + "NCI-H23", + "NCI-H2444", + "NCI-H358", + "NCI-H441", + "NCI-H647", + "NCI-H727", + "NCI-H747", + "Panc 02.03", + "Panc 03.27", + "Panc 04.03", + "Panc 08.13", + "Panc 10.05", + "PaTu 8902", + "PK-1", + "PK-45H", + "PK-59", + "QGP-1", + "RCM-1", + "RERF-LC-Ad2", + "SHP-77", + "SK-CO-1", + "SK-LU-1", + "SNU-407", + "SNU-C2A", + "SU.86.86", + "SW1463", + "SW1573", + "SW1990", + "SW403", + "SW480", + "SW620", + "SW837", + "SW900", + "T3M-10", + "T84", + "YAPC", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", "c.1149C > A\u00a0NF1-mutant hiPSCs", "c.1185+1G > A\u00a0NF1-mutant hiPSCs", "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", "c.5425C > T\u00a0NF1-mutant hiPSCs", "c.6619C > T\u00a0NF1-mutant hiPSCs", - "cNF00.10a", - "cNF04.9a", - "cNF97.2a", - "cNF97.2b", - "cNF98.4c", - "cNF98.4d", - "hTERT NF1 ipNF00.6", - "hTERT NF1 ipNF03.3", - "hTERT NF1 ipNF04.4", - "hTERT NF1 ipNF05.5", - "hTERT NF1 ipNF05.5 (Mixed clones)", - "hTERT NF1 ipNF95.11b C", - "hTERT NF1 ipNF95.11b C/T", - "hTERT NF1 ipNF95.6", - "hTERT NF1 ipn06.2 A", - "hTERT NF1 ipnNF09.4", - "hTERT NF1 ipnNF95.11c", - "hTERT NF1 sipnNF95.12B", - "hTERT SC ipn97.4", - "hTERT ipn02.3 2\u03bb", - "hTERT ipn02.8", - "i28cNF", - "iPSC NF1 +/- BJFF.6 bkgd", - "iPSC NF1 WT", - "iPSC Y489C; Exon 13 cryptic splice", - "icNF00.10a", - "icNF04.9a", - "icNF09.5", - "icNF18.1a", + "HS53T", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "N10", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NF1C-FiPS-SV4F7", + "NF1\u2010iN", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "SOX10+\u00a0SLC", + "U87-NF1-419", "icNF93.1a", - "icNF97.2a", - "icNF97.2b", "icNF97.5", - "icNF98.4c", - "icNF98.4d", "icNF99.1", + "icNF09.5", + "icNF18.1a", "ipNF08.1.5", - "sNF02.2", - "sNF94.3", - "sNF96.2", + "HS-PSS", + "HS-Sch-2", "AC007-hTERT", "Ben-Men-1", "Fb93.1", @@ -1300,98 +2470,99 @@ "primary cultured fibroblast cell", "sMPNST", "sc93.1", - "129-Nf1/Nci", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", - "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", - "B6-129S4-Nf1-/+;Trp53-/+cis", + "NF1flox4/Arg681*;Dhh-Cre", + "Nf1tm1d(KOMP)Wtsi", "B6.129(Cg)-Nf1tm1Par/J", - "B6.129S1-Nf1tm1Cbr/J", + "Nf1pArg1947mp1", + "Nf1tm1c(KOMP)Wtsi", "B6.129S2-Nf1tm1Tyj/J", - "B6.129S6-Nf1/Nci", "B6.129S6-Nf1tm1Fcr/J", - "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", + "Nf1tm1.1Kest", + "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", + "Nf14F/4F;CAGGCre-ERTM", + "B6.129S1-Nf1tm1Cbr/J", + "Nf1tm2.1Kest", + "NF1SynIKO", + "Nf1+/-GFAPCKO", + "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", + "NF1fl/fl;Dhh-Cre", + "NCC-MPNST3-X2", + "Nf14F/Arg681*", + "Nf1flox/-;hGFAP-Cre", + "129-Nf1/Nci", + "B6.129S6-Nf1/Nci", "B6/JGpt-Nf1/Gpt", "B6/JGpt-Nf1/Gpt", - "B6;129-Trp53tm1Tyj Nf1tm1Tyj Suz12Gt(Betageo)1Khe/KcichJ", - "B6;129S2-Trp53tm1Tyj Nf1tm1Tyj/J", "B6;CBA-Nf1/Flmg", "C3HeB/FeJ-Nf1/Ieg", - "C57BL/6-Nf1/Mmjax", "C57BL/6JSmoc-Nf1em1Smoc", "C57BL/6JSmoc-Nf1tm1(flox)Smoc", + "C57BL/6-Nf1/Mmjax", "C57BL/6N-Nf1/Mmucd", - "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1flox/mut; GFAP-Cre", + "Nf1-/+;Trp53-/+cis", + "Nf1flox/flox", + "Nf1-/-", + "Nf1+/-", + "Nf1flox/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/-", + "129T2/SvEmsJ::C57Bl/6NTac Nf1+/+", + "B6-129S4-Nf1-/+;Trp53-/+cis", "CisNf1+/-; p53+/-", - "Cnp-EGFR (Pten-het/C-EGFR)", "Cnp-EGFR (deltaPten/C-EGFR)", + "Cnp-EGFR (Pten-het/C-EGFR)", "Cre(Col2.3Cre)", "Cx3cr1+/gfp", "DelE17", - "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "delta-ira1 delta-ira2 yeast", "Dhh-Cre; Nf1flox/+; Ptenflox/flox", - "Dhh-Cre; Nf1flox/flox; Ptenflox/+", - "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", "Dhh-Cre; Ptenflox/+", "Dhh-Cre; Ptenflox/flox", + "Dhh-Cre; Nf1flox/flox; Ptenflox/+", + "Dhh-Cre; Nf1flox/flox; Ptenflox/flox", + "dNf1 Drosophila", "Krox20;Nf1flox/-", + "miR-155 -/-;Nf1flox/flox ;DhhCre", + "miR-155 +/-;Nf1flox/+", + "miR-155 +/-;Nf1flox/+;DhhCre", "MPNST-Nf1-001", "MPNST-Nf1-002", "MPNST-Nf1-S462", "MPNST-SP-001", "MPSNT-SP-002", - "NCC-MPNST3-X2", - "NF1SynIKO", - "NF1fl/fl;Dhh-Cre", - "NF1flox4/Arg681*;Dhh-Cre", - "Nf1 +/\u03944", - "Nf1 Arg681*/Arg681*", - "Nf1 GEM", - "Nf1 Ocl-/-", "Nf1 flox/+; DhhCre/+", "Nf1 heterozygous mutant minipig", - "Nf1 \u03944/\u03944", + "Nf1P1/Nf1E1 Drosophila", + "Nf1 GEM", "Nf1(31)", - "Nf1+/-", + "Nf1-/- Drosophila", + "Nf1-/-MyoD", + "Nf1:p53", "Nf1+/- P53+/-", - "Nf1+/-GFAPCKO", "Nf1+/-x129S2/SvHsd", "Nf1+/Arg681", - "Nf1+/R681X", "Nf1+/ex42del pig", - "Nf1+/\u03944", - "Nf1-/+;Trp53-/+cis", - "Nf1-/-", - "Nf1-/- Drosophila", - "Nf1-/-MyoD", + "Nf1+/R681X", "Nf14F/4F; DhhCre", - "Nf14F/4F;CAGGCre-ERTM", - "Nf14F/Arg681*", - "Nf14F/Arg681*;CAGGCre-ERTM", - "Nf1:p53", - "Nf1Dsk9/+", - "Nf1E1 Drosophila", - "Nf1Fcr", - "Nf1Gly848Arg/Gly848Arg", - "Nf1P1 Drosophila", - "Nf1P1/Nf1E1 Drosophila", - "Nf1Prx1-/-", - "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1+/\u03944", "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", - "Nf1aL1247X zebrafish", - "Nf1adelta5 zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", "Nf1adelta8 zebrafish", - "Nf1b+10 zebrafish", + "Nf1aL1247X zebrafish", "Nf1bdelta55 zebrafish", - "Nf1flox/+;P0A-Cre(+)", - "Nf1flox/-", + "Nf1Dsk9/+", + "Nf1E1 Drosophila", + "Nf1Fcr", "Nf1flox/-; GFAP-Cre; CD11b-TK", "Nf1flox/-; GFAP-Cre; Cx3cr1+/gfp", "Nf1flox/-;Col2.3Cre(+)", "Nf1flox/-;Cx3cr1+/gfp", "Nf1flox/-;Krox20-Cre", "Nf1flox/-;P0A-Cre-", - "Nf1flox/-;hGFAP-Cre", + "Nf1flox/+;P0A-Cre(+)", "Nf1flox/flox; NG2-Cre", "Nf1flox/flox;Cx3cr1+/gfp", "Nf1flox/flox;Islet1-Cre", @@ -1401,27 +2572,26 @@ "Nf1flox/flox;Rac1flox/+;PostnCre(+)", "Nf1flox/floxRac1flox/flox;PostnCre(+)", "Nf1flox/mut", - "Nf1flox/mut; GFAP-Cre", "Nf1flox/mut; NG2-Cre", "Nf1flox/mut; Ptenflox/wt; GFAP-Cre (FMPC)", - "Nf1pArg1947mp1", - "Nf1tm1.1Kest", + "Nf1Gly848Arg/Gly848Arg", + "Dhh-Cre; Nf1flox/+; Ptenflox/+", + "Nf1 Ocl-/-", + "Nf1P1 Drosophila", + "Nf1Prx1-/-", "Nf1tm1a(KOMP)Wtsi", - "Nf1tm1c(KOMP)Wtsi", - "Nf1tm1d(KOMP)Wtsi", - "Nf1tm2.1Kest", + "CAMK2-CreTg/+ ; flox-NrasG12VTg/+", "P0-GGFb3", "PlpCre;Nf1flox/+", "PlpCreERT; Nf1flox/flox; eGFP", "Prx1-Cre+/- Nf1flox/+", "Prx1-Cre+/- Nf1flox/flox", - "Spred1+/-", "Spred1-/-", - "dNf1 Drosophila", - "delta-ira1 delta-ira2 yeast", - "miR-155 +/-;Nf1flox/+", - "miR-155 +/-;Nf1flox/+;DhhCre", - "miR-155 -/-;Nf1flox/flox ;DhhCre", + "Spred1+/-", + "Nf1 Arg681*/Arg681*", + "Nf1 \u03944/\u03944", + "Nf1 +/\u03944", + "B6.FVB-Tg(EIIa-cre)C5379Lmgd/J", "C57BL/6J", "GFAP-Cre; Nf1-C383X/Flox", "GFAP-Cre; Nf1-G848R/Flox", @@ -1441,31 +2611,79 @@ "Prss56Cre;R26mT" ] }, - "type": "array", + "type": [ + "array", + "null" + ], "title": "modelSystemName" }, + "modelSystemType": { + "description": "Categories of model systems used in research", + "enum": [ + "cell line", + "animal model", + "organoid", + "patient-derived xenograft" + ], + "title": "modelSystemType", + "type": "string" + }, "nf1Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF1 gene in the biospecimen from which the data were derived, if known.", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf1Genotype" }, "nf2Genotype": { + "anyOf": [ + { + "description": "", + "enum": [ + "+/+", + "+/-", + "-/-", + "Unknown" + ], + "title": "Genotype", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Genotype of NF2 gene in the biospecimen from which the data were derived, if known", "type": "string", - "enum": [ - "+/+", - "+/-", - "-/-", - "Unknown", - "Unknown" - ], "title": "nf2Genotype" }, "nucleicAcidSource": { @@ -1513,7 +2731,10 @@ }, "parentSpecimenID": { "description": "A unique identifier (non-PII) that represents the parent specimen (sample) from which the data came from, e.g. the single parent tumor that was subsectioned into several samples. The parentSpecimenID can be the same as specimenID when there is no subsectioning.\n", - "type": "string", + "type": [ + "string", + "null" + ], "title": "parentSpecimenID" }, "platform": { @@ -1548,19 +2769,28 @@ }, "readDepth": { "description": "If available, the coverage statistic as output from bedtools coverage or samtools stats.", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readDepth" }, "readLength": { "description": "Number of base pairs (bp) sequenced for a read", - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readLength" }, "readPair": { "description": "The read of origin, Read 1 or Read 2", "maximum": 2, "minimum": 1, - "type": "integer", + "type": [ + "integer", + "null" + ], "title": "readPair" }, "resourceType": { @@ -1588,14 +2818,38 @@ "type": "string" }, "sex": { + "anyOf": [ + { + "description": "", + "enum": [ + "Female", + "Male" + ], + "title": "SexEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Unknown" + ], + "title": "UnknownEnum", + "type": "string" + }, + { + "description": "", + "enum": [ + "Not Applicable" + ], + "title": "NotApplicableEnum", + "type": "string" + }, + { + "type": "null" + } + ], "description": "Phenotypic expression of chromosomal makeup that defines a study subject as male, female, or other.", "type": "string", - "enum": [ - "Female", - "Male", - "Unknown", - "Not Applicable" - ], "title": "sex" }, "species": { @@ -1638,44 +2892,64 @@ "type": "string" }, "specimenType": { + "anyOf": [ + { + "description": "Tissue is a group of cells that have similar structure and that function together as a unit.", + "enum": [ + "Buccal Mucosa", + "Buffy Coat", + "CDX tissue", + "Dorsal Root Ganglion", + "PDX tissue", + "blood", + "bone marrow", + "cerebral cortex", + "connective tissue", + "embryonic tissue", + "meninges", + "microtissue", + "nerve tissue", + "optic nerve", + "organoid", + "plasma", + "primary tumor", + "retina", + "sciatic nerve", + "serum", + "spheroid", + "splenocyte", + "tumor-adjacent normal", + "whole brain" + ], + "title": "Tissue", + "type": "string" + }, + { + "description": "This preferred root in the UBERON ontology is meant to cover organism-produced substances (bodily secretions and excreta) commonly used as assay specimens.", + "enum": [ + "mucus", + "saliva", + "stool", + "sweat", + "urine" + ], + "title": "OrganismSubstance", + "type": "string" + }, + { + "type": "null" + } + ], "description": "The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.\n", "type": "string", - "enum": [ - "Buccal Mucosa", - "Buffy Coat", - "CDX tissue", - "Dorsal Root Ganglion", - "PDX tissue", - "blood", - "bone marrow", - "cerebral cortex", - "connective tissue", - "embryonic tissue", - "meninges", - "microtissue", - "nerve tissue", - "optic nerve", - "organoid", - "plasma", - "primary tumor", - "retina", - "sciatic nerve", - "serum", - "spheroid", - "splenocyte", - "tumor-adjacent normal", - "whole brain", - "mucus", - "saliva", - "stool", - "sweat", - "urine" - ], "title": "specimenType" }, "targetDepth": { "description": "The targeted read depth prior to sequencing.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "targetDepth" }, "tumorType": { @@ -1750,9 +3024,431 @@ "individualID", "species", "diagnosis", + "modelSystemType", + "modelSpecies", + "cellLineCategory", + "cellLineGeneticDisorder", "fileFormat", "resourceType" ], "title": "WGSTemplate", - "type": "object" + "type": "object", + "$defs": { + "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum": { + "enum": [ + "90-8", + "NCC-MPNST3-X2-C1", + "ST88-14", + "HeLa SilenciX NF1", + "sNF94.3", + "T265", + "Nf1-/- Epithelial lung cells", + "NCC-MPNST3-C1", + "NCC-MPNST5-C1", + "NCC-MPNST2-C1", + "S462", + "sNF02.2", + "S520", + "sNF96.2", + "S462.TY", + "NCC-MPNST4-C1", + "NCC-MPNST1-C1", + "GM01858", + "GM23312", + "1507.2", + "FMS-1", + "FU-SFT8710", + "MPNST-14", + "MPNST-642", + "MPNST-90", + "MPNST-91", + "MPNST-92", + "NFS-1", + "NMS-2", + "NMS-2PC", + "ST88-3", + "TM-31", + "2-004", + "BTSC 232", + "BTSC 233", + "BTSC 3021", + "BTSC 3047", + "BTSC 349", + "BTSC 380", + "HSC1\u03bb", + "JH-2-002", + "JH-2-009", + "JH-2-031", + "MPNST 724", + "NF1-/- hiPSC-SCPs", + "NF1+/- hiPSC-SCPs", + "NF10.1", + "NF11.1", + "NMS-PC", + "A68", + "WZJ", + "S462s", + "S462sp", + "U87-NF1-419" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum": { + "enum": [ + "3PNF_SiPSsv_MM_11", + "3PNF_FiPSsv_PM_2", + "5PNF_TDiPSsv_PM_6", + "7PNF_SiPSrv_PM_12", + "5PNF_TDiPSsv_MM_4", + "6PNF_SiPSrv_PM_2", + "HPS1312", + "HPS1313", + "HPS1314", + "HPS1315", + "HPS1316", + "HPS1317", + "HPS2250", + "HPS2251", + "HPS2252", + "HPS2253", + "HPS2254", + "HPS2255", + "MCRIi020-A", + "MCRIi021-A", + "MCRIi022-A", + "MCRIi023-A", + "SMBCi003-A", + "SMBCi003-B", + "SMBCi003-C", + "c.1149C > A\u00a0NF1-mutant hiPSCs", + "c.1185+1G > A\u00a0NF1-mutant hiPSCs", + "c.3431-32_dupGT\u00a0NF1-mutant hiPSCs", + "c.5425C > T\u00a0NF1-mutant hiPSCs", + "c.6619C > T\u00a0NF1-mutant hiPSCs", + "NF1C-FiPS-SV4F7", + "SOX10+\u00a0SLC" + ], + "type": "string" + }, + "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "GM23338", + "iPSC NF1 WT", + "BJFF.6", + "iPSC NF1 +/- BJFF.6 bkgd", + "iPSC Y489C; Exon 13 cryptic splice", + "PEO4-iPSC-OSKM-03", + "PEO4-iPSC-OSKM-05" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "GM11601", + "GM01634", + "GM01641", + "GM01861", + "GM03420", + "GM03421", + "GM09534", + "GM09535", + "GM09539", + "GM09616", + "GM09619", + "GM09627", + "GM09628", + "GM09633", + "GM09634", + "GM09635", + "GM09637", + "GM09690", + "GM09692", + "GM09693", + "GM21674", + "GM21843", + "GM21844", + "GM21865", + "GM22606", + "GM22608", + "DD2345", + "QQ0588", + "N10" + ], + "type": "string" + }, + "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM11602", + "GM09536", + "GM09617", + "GM09618", + "GM09620", + "GM09621", + "GM09622", + "GM09625", + "GM09626", + "GM09629", + "GM09630", + "GM09631", + "GM09632", + "GM09636", + "GM09638", + "GM09639", + "GM09640", + "GM09641", + "GM09642", + "GM09649", + "GM09650", + "GM09651", + "GM09652", + "GM09688", + "GM09689", + "GM09691", + "GM09694", + "GM09886", + "GM09887", + "GM09944", + "GM21845" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "hTERT NF1 ipnNF95.11c", + "hTERT NF1 ipn06.2 A", + "icNF98.4c", + "hTERT NF1 ipNF05.5", + "icNF04.9a", + "icNF00.10a", + "hTERT NF1 ipNF05.5 (Mixed clones)", + "hTERT NF1 ipnNF09.4", + "i28cNF", + "hTERT NF1 ipNF04.4", + "hTERT NF1 sipnNF95.12B", + "icNF97.2a", + "hTERT NF1 ipNF00.6", + "hTERT NF1 ipNF95.11b C/T", + "hTERT NF1 ipNF95.6", + "icNF98.4d", + "hTERT NF1 ipNF95.11b C", + "icNF97.2b", + "hTERT NF1 ipNF03.3", + "icNF93.1a", + "icNF97.5", + "icNF99.1", + "icNF09.5", + "icNF18.1a", + "ipNF08.1.5" + ], + "type": "string" + }, + "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "hTERT SC ipn97.4", + "Schwann cell NF1 -/- (iPN97.4 #24)", + "Schwann cell NF1 -/- with R816X mNf1 cDNA", + "hTERT ipn02.3 2\u03bb", + "hTERT ipn02.8", + "Schwann cell NF1 -/- with WT tagged mNf1 cDNA", + "Schwann cell NF1 -/- with R681X mNf1 cDNA" + ], + "type": "string" + }, + "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "SZ-NF4", + "KCL025", + "SZ-NF1", + "SZ-NF2", + "Lis42_NF1_1N", + "Lis47_NF1_2N", + "KCL024", + "RG-137", + "RG-138", + "RG-139", + "RG-140", + "RG-141", + "RG-235", + "RG-315", + "STR-I-437-NF1", + "STR-I-441-NF1", + "STR-I-443-NF1", + "SZ-NF6" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum": { + "enum": [ + "NF1", + "28cNF", + "cNF98.4d", + "cNF00.10a", + "cNF97.2b", + "cNF04.9a", + "cNF97.2a", + "cNF98.4c", + "GM00622", + "GM01633", + "GM01639", + "GM01859", + "GM21675", + "GM22279", + "GM22607", + "GM22609" + ], + "type": "string" + }, + "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum": { + "enum": [ + "ScienCell Schwann cells" + ], + "type": "string" + }, + "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501", + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "MCF10A_NF1_1", + "MCF10A_NF1_7A1", + "MCF10A_NF1_7B2" + ], + "type": "string" + }, + "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum": { + "enum": [ + "Nf1-/- skin-derived precursor cells", + "NF1\u2010iN" + ], + "type": "string" + }, + "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "10/9CRC1", + "4/30PRR", + "862L", + "9/3L" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum": { + "enum": [ + "Nf1Arg681*/Arg681* MEFs", + "Nf1Arg681*/+ ES", + "Nf1Arg681*/Arg681* ES" + ], + "type": "string" + }, + "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "NF1-R68X Embryonic cells", + "KOMP ES cell line Nf1", + "KOMP ES cell line Nf1", + "SIGTR ES cell line AA0320", + "BayGenomics ES cell line XF344" + ], + "type": "string" + }, + "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum": { + "enum": [ + "WT ES" + ], + "type": "string" + }, + "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10502", + "GM10657", + "GM10659", + "GM12517" + ], + "type": "string" + }, + "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum": { + "enum": [ + "CPTC-NF1-1", + "CPTC-NF1-2", + "CPTC-NF1-3" + ], + "type": "string" + }, + "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum": { + "enum": [ + "Dhh-Cre; NF1Arg681*/flox Schwann Cells" + ], + "type": "string" + }, + "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum": { + "enum": [ + "CML-6M", + "MH/Nike", + "OSW", + "STSA-1" + ], + "type": "string" + }, + "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "XF", + "XL110" + ], + "type": "string" + }, + "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum": { + "enum": [ + "Dh5 alpha" + ], + "type": "string" + }, + "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum": { + "enum": [ + "GM10501" + ], + "type": "string" + }, + "AnimalModelDaniorerioNeurofibromatosistype1Enum": { + "enum": [ + "Nf1adelta5 zebrafish", + "Nf1b+10 zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m zebrafish", + "Nf1a+/-; Nf1b-/-; p53m/m; sox10:mCherry zebrafish", + "Nf1a+/-; Nf1b-/-; p53e7/e7 zebrafish", + "Nf1adelta8 zebrafish", + "Nf1aL1247X zebrafish", + "Nf1bdelta55 zebrafish" + ], + "type": "string" + }, + "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum": { + "enum": [ + "dNf1 Drosophila", + "Nf1P1/Nf1E1 Drosophila", + "Nf1-/- Drosophila", + "Nf1E1 Drosophila", + "Nf1P1 Drosophila" + ], + "type": "string" + }, + "AnimalModelSusscrofaNeurofibromatosistype1Enum": { + "enum": [ + "Nf1pArg1947mp1", + "Nf1 heterozygous mutant minipig", + "Nf1+/ex42del pig" + ], + "type": "string" + }, + "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum": { + "enum": [ + "delta-ira1 delta-ira2 yeast" + ], + "type": "string" + } + } } \ No newline at end of file diff --git a/registered-json-schemas/WorkflowReport.json b/registered-json-schemas/WorkflowReport.json index ea87e016..a0d6b08a 100644 --- a/registered-json-schemas/WorkflowReport.json +++ b/registered-json-schemas/WorkflowReport.json @@ -222,7 +222,10 @@ }, "relatedDataset": { "description": "Reference to a relevant dataset entity.", - "type": "string", + "type": [ + "string", + "null" + ], "title": "relatedDataset" }, "workflow": { @@ -248,7 +251,10 @@ }, "workflowLink": { "description": "Workflow URL reference", - "type": "string", + "type": [ + "string", + "null" + ], "title": "workflowLink" }, "fileFormat": { diff --git a/utils/add_conditional_enum_filtering.py b/utils/add_conditional_enum_filtering.py new file mode 100644 index 00000000..6250071c --- /dev/null +++ b/utils/add_conditional_enum_filtering.py @@ -0,0 +1,428 @@ +#!/usr/bin/env python3 +""" +Add conditional enum filtering to generated JSON schemas. + +This script post-processes LinkML-generated JSON schemas to add if/then/else +conditionals that filter modelSystemName and individualID enum values based on +user selections in modelSystemType, modelSpecies, cellLineCategory, and +cellLineGeneticDisorder. + +For cell lines, both modelSystemName and individualID reference syn51730943 +(the NF tools database), so they share the same conditional enum filtering logic. + +This enables the Synapse curator grid to show contextually relevant options +without hitting the 100-value enum limit. +""" + +import json +import os +import sys +from pathlib import Path +from typing import Dict, List, Any + + +# Mapping of filter combinations to enum subset names +# Generated by analyzing the filtered enum files +CONDITIONAL_MAPPINGS = [ + # Cell Lines - Human - Cancer + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Cancer cell line", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineHomosapiensCancercelllineNeurofibromatosistype1Enum" + }, + # Cell Lines - Human - iPSC + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Induced pluripotent stem cell", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineHomosapiensInducedpluripotentstemcellNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Induced pluripotent stem cell", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineHomosapiensInducedpluripotentstemcellNoknowngeneticdisorderEnum" + }, + # Cell Lines - Human - Transformed + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Transformed cell line", + "cellLineGeneticDisorder": "Neurofibromatosistype 1", + "enum": "CellLineHomosapiensTransformedcelllineNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Transformed cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineHomosapiensTransformedcelllineNoknowngeneticdisorderEnum" + }, + # Cell Lines - Human - Telomerase immortalized + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Telomerase immortalized cell line", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineHomosapiensTelomeraseimmortalizedcelllineNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Telomerase immortalized cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineHomosapiensTelomeraseimmortalizedcelllineNoknowngeneticdisorderEnum" + }, + # Cell Lines - Human - Embryonic stem cell + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Embryonic stem cell", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineHomosapiensEmbryonicstemcellNeurofibromatosistype1Enum" + }, + # Cell Lines - Human - Finite cell line + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Finite cell line", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineHomosapiensFinitecelllineNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Finite cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineHomosapiensFinitecelllineNoknowngeneticdisorderEnum" + }, + # Cell Lines - Human - Other categories + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Hybrid cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineHomosapiensHybridcelllineNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Spontaneously immortalized cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineHomosapiensSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Homo sapiens", + "cellLineCategory": "Undefined cell line type", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineHomosapiensUndefinedcelllinetypeNeurofibromatosistype1Enum" + }, + # Cell Lines - Mouse + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Cancer cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineMusmusculusCancercelllineNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Embryonic stem cell", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineMusmusculusEmbryonicstemcellNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Embryonic stem cell", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineMusmusculusEmbryonicstemcellNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Induced pluripotent stem cell", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineMusmusculusInducedpluripotentstemcellNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Hybrid cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineMusmusculusHybridcelllineNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Hybridoma", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineMusmusculusHybridomaNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Mus musculus", + "cellLineCategory": "Spontaneously immortalized cell line", + "cellLineGeneticDisorder": "Neurofibromatosis type 1", + "enum": "CellLineMusmusculusSpontaneouslyimmortalizedcelllineNeurofibromatosistype1Enum" + }, + # Cell Lines - Other species + { + "modelSystemType": "cell line", + "modelSpecies": "Canis lupus familiaris", + "cellLineCategory": "Cancer cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineCanislupusfamiliarisCancercelllineNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Xenopus laevis", + "cellLineCategory": "Spontaneously immortalized cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineXenopuslaevisSpontaneouslyimmortalizedcelllineNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Escherichia coli", + "cellLineCategory": "Undefined cell line type", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineEscherichiacoliUndefinedcelllinetypeNoknowngeneticdisorderEnum" + }, + { + "modelSystemType": "cell line", + "modelSpecies": "Cricetulus griseus", + "cellLineCategory": "Hybrid cell line", + "cellLineGeneticDisorder": "No known genetic disorder", + "enum": "CellLineCricetulusgriseusHybridcelllineNoknowngeneticdisorderEnum" + }, + # Animal Models - simplified (no category for animal models) + { + "modelSystemType": "animal model", + "modelSpecies": "Danio rerio", + "enum": "AnimalModelDaniorerioNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "animal model", + "modelSpecies": "Drosophila melanogaster", + "enum": "AnimalModelDrosophilamelanogasterNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "animal model", + "modelSpecies": "Sus scrofa", + "enum": "AnimalModelSusscrofaNeurofibromatosistype1Enum" + }, + { + "modelSystemType": "animal model", + "modelSpecies": "Saccharomyces cerevisiae", + "enum": "AnimalModelSaccharomycescerevisiaeNeurofibromatosistype1Enum" + }, +] + + +def create_conditional_rule(mapping: Dict[str, str]) -> Dict[str, Any]: + """ + Create an if/then conditional rule for a filter combination. + + Args: + mapping: Dict with filter field values and enum name + + Returns: + Dict with if/then structure for allOf + """ + # Build the if condition + if_properties = {} + required_fields = [] + + if "modelSystemType" in mapping: + if_properties["modelSystemType"] = {"const": mapping["modelSystemType"]} + required_fields.append("modelSystemType") + + if "modelSpecies" in mapping: + # modelSpecies can be array, so check if it contains the value + if_properties["modelSpecies"] = {"const": mapping["modelSpecies"]} + required_fields.append("modelSpecies") + + if "cellLineCategory" in mapping: + if_properties["cellLineCategory"] = {"const": mapping["cellLineCategory"]} + required_fields.append("cellLineCategory") + + if "cellLineGeneticDisorder" in mapping: + if_properties["cellLineGeneticDisorder"] = {"const": mapping["cellLineGeneticDisorder"]} + required_fields.append("cellLineGeneticDisorder") + + # Build the then condition - reference the filtered enum + # Both modelSystemName and individualID use the same enum values + # (for cell lines, individualID references syn51730943, same as modelSystemName) + then_properties = { + "modelSystemName": { + "items": { + "$ref": f"#/$defs/{mapping['enum']}" + } + }, + "individualID": { + "items": { + "$ref": f"#/$defs/{mapping['enum']}" + } + } + } + + return { + "if": { + "properties": if_properties, + "required": required_fields + }, + "then": { + "properties": then_properties + } + } + + +def add_conditionals_to_schema(schema: Dict[str, Any]) -> Dict[str, Any]: + """ + Add conditional enum filtering to a JSON schema. + + Args: + schema: The JSON schema dict + + Returns: + Modified schema with conditionals added + """ + # Check if this schema has modelSystemName or individualID field + properties = schema.get("properties", {}) + has_model_system_name = "modelSystemName" in properties + has_individual_id = "individualID" in properties + + if not has_model_system_name and not has_individual_id: + return schema # Neither field present, skip + + print(f" Adding {len(CONDITIONAL_MAPPINGS)} conditional rules...") + + # Create allOf rules + conditional_rules = [create_conditional_rule(mapping) for mapping in CONDITIONAL_MAPPINGS] + + # Add to schema + if "allOf" in schema: + # Append to existing allOf + schema["allOf"].extend(conditional_rules) + else: + # Create new allOf + schema["allOf"] = conditional_rules + + # Add the filtered enum definitions to $defs + if "$defs" not in schema: + schema["$defs"] = {} + + # Load enum definitions from generated files + generated_dir = Path("modules/Sample/generated") + for mapping in CONDITIONAL_MAPPINGS: + enum_name = mapping["enum"] + enum_file = generated_dir / f"{enum_name}.yaml" + + if enum_file.exists(): + # Load the YAML file and extract enum values + import yaml + with open(enum_file) as f: + enum_data = yaml.safe_load(f) + + if "enums" in enum_data and enum_name in enum_data["enums"]: + enum_values = list(enum_data["enums"][enum_name]["permissible_values"].keys()) + + # Add to $defs + schema["$defs"][enum_name] = { + "enum": enum_values, + "type": "string" + } + + return schema + + +def process_schema_file(schema_path: Path) -> bool: + """ + Process a single JSON schema file. + + Args: + schema_path: Path to JSON schema file + + Returns: + True if modified, False otherwise + """ + print(f"\nProcessing {schema_path.name}...") + + try: + with open(schema_path) as f: + schema = json.load(f) + + # Check if this schema needs conditionals + if "properties" not in schema or "modelSystemName" not in schema.get("properties", {}): + print(" Skipping (no modelSystemName field)") + return False + + # Add conditionals + modified_schema = add_conditionals_to_schema(schema) + + # Write back + with open(schema_path, 'w') as f: + json.dump(modified_schema, f, indent=2) + + print(" ✓ Added conditional filtering") + return True + + except Exception as e: + print(f" ✗ Error: {e}") + return False + + +def main(): + import argparse + + parser = argparse.ArgumentParser(description='Add conditional enum filtering to JSON schemas') + parser.add_argument('--schema-dir', default='registered-json-schemas', + help='Directory containing JSON schema files') + parser.add_argument('--dry-run', action='store_true', + help='Show what would be done without making changes') + + args = parser.parse_args() + + schema_dir = Path(args.schema_dir) + if not schema_dir.exists(): + print(f"Error: Schema directory not found: {schema_dir}") + sys.exit(1) + + print("="*60) + print("ADDING CONDITIONAL ENUM FILTERING TO JSON SCHEMAS") + print("="*60) + print(f"Schema directory: {schema_dir}") + print(f"Dry run: {args.dry_run}") + print() + + # Process all JSON schema files + schema_files = list(schema_dir.glob("*.json")) + modified_count = 0 + + for schema_file in sorted(schema_files): + if not args.dry_run: + if process_schema_file(schema_file): + modified_count += 1 + else: + # Dry run - just check + with open(schema_file) as f: + schema = json.load(f) + properties = schema.get("properties", {}) + if properties and ("modelSystemName" in properties or "individualID" in properties): + print(f"Would add conditionals to: {schema_file.name}") + modified_count += 1 + + print("\n" + "="*60) + print(f"{'DRY RUN - ' if args.dry_run else ''}COMPLETED") + print("="*60) + print(f"Modified {modified_count} schema files") + + +if __name__ == '__main__': + main() diff --git a/utils/create_curation_task.py b/utils/create_curation_task.py index 8646b153..c0817282 100644 --- a/utils/create_curation_task.py +++ b/utils/create_curation_task.py @@ -237,15 +237,67 @@ def create_curation_task( # Add essential columns first: id and name only essential_columns = [ Column(name="id", column_type=ColumnType.ENTITYID), - Column(name="name", column_type=ColumnType.STRING, maximum_size=256), + Column(name="name", column_type=ColumnType.STRING, maximum_size=80), ] - # Combine essential columns with schema columns - all_columns = essential_columns + columns + # Reorder schema columns to put important fields first + # Filter fields must come first for conditional filtering to work + priority_order = [ + # Filter fields for conditional enum filtering (MUST be first) + 'modelSystemType', 'modelSpecies', 'cellLineCategory', 'cellLineGeneticDisorder', + # Then the conditional fields + 'modelSystemName', 'individualID', + # Then other key metadata + 'species', 'sex', 'age', 'ageUnit', 'diagnosis', 'tumorType', 'organ', + 'modelSex', 'modelAge', 'modelAgeUnit', + 'assay', 'platform', 'fileFormat', + 'dataType', 'dataSubtype', 'resourceType', + # Then IDs and references + 'specimenID', 'parentSpecimenID', 'aliquotID', + 'antibodyID', 'geneticReagentID', 'assayTarget', 'auxiliaryAsset', + # Then genotypes + 'nf1Genotype', 'nf2Genotype', + # Finally comments + 'comments' + ] + + # Create a dict for fast lookup + column_dict = {col.name: col for col in columns} + + # Build ordered list: priority fields first, then remaining fields + ordered_columns = [] + for field_name in priority_order: + if field_name in column_dict: + ordered_columns.append(column_dict[field_name]) + del column_dict[field_name] + + # Add any remaining columns not in priority list + ordered_columns.extend(column_dict.values()) + + # Combine essential columns with ordered schema columns + all_columns = essential_columns + ordered_columns + + # Check if a file view with this name already exists and delete it + # This ensures we always create a fresh view with the latest column definitions + view_name = f"{data_type}_FileView" + print(f" Checking for existing file view: {view_name}") + + try: + # Try to find an existing entity with this name in the project + existing_view_id = syn.findEntityId(view_name, parent=project_id) + + if existing_view_id: + print(f" Found existing file view {existing_view_id}, deleting...") + syn.delete(existing_view_id) + print(f" Deleted {existing_view_id}") + except Exception as e: + # If findEntityId raises an exception, it means no entity with that name exists + print(f" No existing file view found") # Create the entity view using the new models API + print(f" Creating new file view...") file_view = EntityView( - name=f"{data_type}_FileView", + name=view_name, parent_id=project_id, scope_ids=[upload_folder_id], view_type_mask=ViewTypeMask.FILE, @@ -259,6 +311,24 @@ def create_curation_task( print(f" Folder: {upload_folder_id}") print(f" Data type: {data_type}") + # Check for existing curation tasks with this data_type and delete them + # This prevents conflicts with tasks in trash or existing tasks + print(f" Checking for existing curation tasks with data_type: {data_type}") + try: + # Try to list all curation tasks for this project + existing_tasks = CurationTask.list(project_id=project_id) + + for existing_task in existing_tasks: + if existing_task.data_type == data_type: + print(f" Found existing task {existing_task.task_id}, deleting...") + try: + existing_task.delete() + print(f" Deleted task {existing_task.task_id}") + except Exception as delete_error: + print(f" Warning: Could not delete task {existing_task.task_id}: {delete_error}") + except Exception as e: + print(f" Could not check for existing tasks (may not exist): {e}") + task = CurationTask( project_id=project_id, data_type=data_type, @@ -270,6 +340,7 @@ def create_curation_task( ) # Store the task (use store() method, not create()) + print(f" Creating new curation task...") task = task.store() print(f"\n✓ Curation task created successfully!") diff --git a/utils/fetch_model_system_species.py b/utils/fetch_model_system_species.py new file mode 100644 index 00000000..f33f4c66 --- /dev/null +++ b/utils/fetch_model_system_species.py @@ -0,0 +1,276 @@ +#!/usr/bin/env python3 +""" +Fetch species information for model systems from external APIs. + +This script queries: +- Cellosaurus API for cell line species (CVCL_ RRIDs) +- Jackson Laboratory / MGI for animal model species (IMSR_JAX, MGI, MMRRC RRIDs) +""" + +import requests +import time +import yaml +from typing import Dict, Optional +import re + + +def fetch_cellosaurus_species(cvcl_id: str) -> Optional[str]: + """ + Fetch species from Cellosaurus API for a given CVCL ID. + + Args: + cvcl_id: Cellosaurus ID (e.g., "CVCL_0023" for HEK293) + + Returns: + Species name (e.g., "Homo sapiens") or None if not found + """ + # Clean the ID (remove "rrid:" prefix if present) + cvcl_id = cvcl_id.replace('rrid:', '').replace('CVCL_', 'CVCL-') + + url = f"https://api.cellosaurus.org/cell-line/{cvcl_id}" + + try: + response = requests.get(url, timeout=10) + if response.status_code == 200: + data = response.json() + # Species is in the "species" field + species_data = data.get('species', {}) + if isinstance(species_data, dict): + species_name = species_data.get('name') + return species_name + elif isinstance(species_data, list) and len(species_data) > 0: + # Sometimes it's a list + return species_data[0].get('name') + return None + except Exception as e: + print(f" Error fetching {cvcl_id}: {e}") + return None + + +def infer_animal_model_species(name: str, rrid: str = None, description: str = None) -> Optional[str]: + """ + Infer species for animal models from name, RRID, or description. + + Most animal models in NF research are mouse models. + This function uses heuristics to determine species. + + Args: + name: Model system name + rrid: RRID if available + description: Description if available + + Returns: + Species name or None + """ + # Check RRID prefixes + if rrid: + rrid_lower = rrid.lower() + if 'imsr_jax' in rrid_lower or 'mmrrc' in rrid_lower or 'mgi:' in rrid_lower: + return "Mus musculus" # Jackson Lab and MMRRC are mouse repositories + if 'rgd:' in rrid_lower: + return "Rattus norvegicus" # Rat Genome Database + + # Check name patterns + name_lower = name.lower() + + # Mouse indicators + mouse_indicators = ['b6', 'c57', 'nf1', 'balb/', 'fvb', '129', 'cre', 'flox', + 'mus musculus', 'mouse', 'knockout', 'transgenic'] + if any(ind in name_lower for ind in mouse_indicators): + return "Mus musculus" + + # Zebrafish indicators + zebrafish_indicators = ['zebrafish', 'nf1a', 'nf1b', 'danio'] + if any(ind in name_lower for ind in zebrafish_indicators): + return "Danio rerio" + + # Drosophila indicators + fly_indicators = ['drosophila', 'dnf1', 'nf1e1', 'nf1p1'] + if any(ind in name_lower for ind in fly_indicators): + return "Drosophila melanogaster" + + # Rat indicators + rat_indicators = ['rattus', 'rat'] + if any(ind in name_lower for ind in rat_indicators): + return "Rattus norvegicus" + + # Pig indicators + pig_indicators = ['minipig', 'sus scrofa', 'pig', 'swine'] + if any(ind in name_lower for ind in pig_indicators): + return "Sus scrofa" + + # Check description if available + if description: + desc_lower = description.lower() + if 'mouse' in desc_lower or 'murine' in desc_lower: + return "Mus musculus" + if 'human' in desc_lower: + return "Homo sapiens" + + # Default for unidentified: assume mouse (most common in NF research) + return None + + +def fetch_all_species_info() -> Dict[str, Dict]: + """ + Fetch species information for all model systems. + + Returns: + Dict mapping model system name to metadata including species + """ + # Load existing model system data + with open('modules/Sample/CellLineModel.yaml') as f: + cell_data = yaml.safe_load(f) + + with open('modules/Sample/AnimalModel.yaml') as f: + animal_data = yaml.safe_load(f) + + cell_lines = cell_data['enums']['CellLineModel']['permissible_values'] + animal_models = animal_data['enums']['AnimalModel']['permissible_values'] + + results = {} + + # Process cell lines + print(f"Processing {len(cell_lines)} cell lines...") + for i, (name, meta) in enumerate(cell_lines.items()): + if i > 0 and i % 50 == 0: + print(f" Processed {i}/{len(cell_lines)} cell lines...") + time.sleep(1) # Rate limiting + + species = None + rrid = meta.get('meaning', '') + + if 'CVCL' in rrid or 'cvcl' in rrid.lower(): + # Query Cellosaurus + species = fetch_cellosaurus_species(rrid) + if species: + print(f" {name}: {species} (from Cellosaurus)") + + # Fallback to inference + if not species: + # Try to infer from name + if any(pattern in name.upper() for pattern in ['GM', 'HEK', 'HeLa', 'MCF', 'SK-MEL', 'MPNST', 'iPSC', 'hiPSC']): + species = "Homo sapiens" + elif 'ES cell' in name or 'MEF' in name: + species = "Mus musculus" + + results[name] = { + **meta, + 'species': species, + 'system_type': 'cell line' + } + + # Process animal models + print(f"\nProcessing {len(animal_models)} animal models...") + for name, meta in animal_models.items(): + rrid = meta.get('meaning', '') + description = meta.get('description', '') + species = infer_animal_model_species(name, rrid, description) + + results[name] = { + **meta, + 'species': species, + 'system_type': 'animal model' + } + + return results + + +def generate_species_filtered_enums(species_data: Dict[str, Dict]): + """ + Generate species-filtered enum files. + + Creates separate enum files for each combination of: + - system_type (cell line vs animal model) + - species + """ + # Group by system_type and species + grouped = {} + for name, data in species_data.items(): + system_type = data.get('system_type', 'unknown') + species = data.get('species', 'Unknown') + + if species is None: + species = 'Unknown' + + key = (system_type, species) + if key not in grouped: + grouped[key] = {} + grouped[key][name] = {k: v for k, v in data.items() if k not in ['species', 'system_type']} + + # Print summary + print("\n" + "="*60) + print("SPECIES DISTRIBUTION") + print("="*60) + for (system_type, species), items in sorted(grouped.items(), key=lambda x: -len(x[1])): + print(f"{system_type} + {species}: {len(items)} entries") + + # Save filtered files + print("\n" + "="*60) + print("SAVING SPECIES-FILTERED ENUM FILES") + print("="*60) + + output_dir = 'modules/Sample/generated/' + import os + os.makedirs(output_dir, exist_ok=True) + + for (system_type, species), items in grouped.items(): + # Create safe filename + type_name = system_type.replace(' ', '') + species_name = species.replace(' ', '').replace('.', '') + filename = f"{type_name}_{species_name}.yaml" + enum_name = f"{type_name.capitalize()}{species_name}Enum" + + filepath = os.path.join(output_dir, filename) + + content = f"""# Auto-generated species-filtered model system enum +# System type: {system_type} +# Species: {species} +# Count: {len(items)} entries + +enums: + {enum_name}: + permissible_values: +""" + + for name, meta in sorted(items.items()): + content += f' "{name}":\n' + for key, value in meta.items(): + if isinstance(value, str) and len(value) > 200: + value = value[:200] + "..." + content += f' {key}: {repr(value)}\n' + + with open(filepath, 'w') as f: + f.write(content) + + print(f" Created: {filepath} ({len(items)} entries)") + + +if __name__ == '__main__': + import argparse + + parser = argparse.ArgumentParser(description='Fetch species info for model systems') + parser.add_argument('--dry-run', action='store_true', help='Show what would be done without making changes') + parser.add_argument('--cache', default='species_cache.yaml', help='Cache file for species data') + + args = parser.parse_args() + + # Check if cache exists + import os + if os.path.exists(args.cache): + print(f"Loading species data from cache: {args.cache}") + with open(args.cache) as f: + species_data = yaml.safe_load(f) + else: + print("Fetching species data from APIs...") + species_data = fetch_all_species_info() + + # Save cache + with open(args.cache, 'w') as f: + yaml.dump(species_data, f, default_flow_style=False, sort_keys=False) + print(f"Saved species data to cache: {args.cache}") + + # Generate filtered enums + generate_species_filtered_enums(species_data) + + print("\nDone!") diff --git a/utils/json_schema_entity_view.py b/utils/json_schema_entity_view.py index c1f176a0..f8e34b50 100644 --- a/utils/json_schema_entity_view.py +++ b/utils/json_schema_entity_view.py @@ -118,6 +118,35 @@ def create_entity_view_from_schema_uri( return view.id +def _has_conditional_enum(json_schema: dict[str, Any], field_name: str) -> bool: + """Check if a field has conditional enum filtering via allOf rules. + + Arguments: + json_schema: The JSON Schema in dict form + field_name: The field name to check + + Returns: + True if the field has conditional filtering, False otherwise + """ + all_of = json_schema.get("allOf", []) + for rule in all_of: + # Check if this rule has a 'then' clause that references this field + then_clause = rule.get("then", {}) + then_properties = then_clause.get("properties", {}) + if field_name in then_properties: + # Check if the field uses $ref (indicating conditional enum) + field_spec = then_properties[field_name] + if isinstance(field_spec, dict): + # Check for $ref in items (for list fields like modelSystemName) + if "items" in field_spec and isinstance(field_spec["items"], dict): + if "$ref" in field_spec["items"]: + return True + # Check for direct $ref + if "$ref" in field_spec: + return True + return False + + def _create_columns_from_json_schema(json_schema: dict[str, Any]) -> list[Column]: """Creates a list of Synapse Columns based on the JSON Schema type @@ -144,19 +173,27 @@ def _create_columns_from_json_schema(json_schema: dict[str, Any]) -> list[Column maximum_size = None enum_values = None - # Extract enum values if present (limit to first 1000) - if "enum" in prop_schema: - enum_values = [str(v) for v in prop_schema["enum"][:1000]] - - # For list types, check if enum is nested in items - if column_type in LIST_TYPE_DICT.values() and "items" in prop_schema: - if isinstance(prop_schema["items"], dict) and "enum" in prop_schema["items"]: - enum_values = [str(v) for v in prop_schema["items"]["enum"][:1000]] - - if column_type == "STRING": - maximum_size = 250 + # Check if this field has conditional enum filtering + # Fields with conditional filtering should NOT have enum_values set + has_conditional = _has_conditional_enum(json_schema, name) + + # For fields with SMALL enum lists (< 20 values) and NO conditional filtering, + # set enum_values to provide dropdown UI in curator grid + # JSON Schema binding provides validation but NOT dropdown UI + if not has_conditional: + if "enum" in prop_schema and len(prop_schema["enum"]) < 20: + enum_values = [str(v) for v in prop_schema["enum"]] + elif column_type in LIST_TYPE_DICT.values() and "items" in prop_schema: + if isinstance(prop_schema["items"], dict) and "enum" in prop_schema["items"]: + if len(prop_schema["items"]["enum"]) < 20: + enum_values = [str(v) for v in prop_schema["items"]["enum"]] + + # Use conservative maximum_size values to stay under Synapse's 64KB row limit + # With ~50 total columns (schema + system), we need to keep sizes small + if column_type == ColumnType.STRING: + maximum_size = 80 # Most metadata values fit in 80 chars if column_type in LIST_TYPE_DICT.values(): - maximum_size = 100 + maximum_size = 40 # List item size (total row size = size × list length) column = Column( name=name, @@ -185,9 +222,19 @@ def _get_column_type_from_js_property(js_property: dict[str, Any]) -> ColumnType if "enum" in js_property: return ColumnType.STRING if "type" in js_property: - if js_property["type"] == "array": + prop_type = js_property["type"] + # Handle nullable types (e.g., ['array', 'null'], ['string', 'null']) + if isinstance(prop_type, list): + # Filter out 'null' and get the actual type + non_null_types = [t for t in prop_type if t != "null"] + if non_null_types: + prop_type = non_null_types[0] # Use the first non-null type + else: + return ColumnType.STRING # Default if only null + + if prop_type == "array": return _get_list_column_type_from_js_property(js_property) - return TYPE_DICT.get(js_property["type"], ColumnType.STRING) + return TYPE_DICT.get(prop_type, ColumnType.STRING) # A oneOf list usually indicates that the type could be one or more different things if "oneOf" in js_property and isinstance(js_property["oneOf"], list): return _get_column_type_from_js_one_of_list(js_property["oneOf"]) @@ -214,9 +261,18 @@ def _get_column_type_from_js_one_of_list(js_one_of_list: list[Any]) -> ColumnTyp type_items = [item for item in items if "type" in item if item["type"] != "null"] if len(type_items) == 1: type_item = type_items[0] - if type_item["type"] == "array": + prop_type = type_item["type"] + # Handle nullable types in oneOf items + if isinstance(prop_type, list): + non_null_types = [t for t in prop_type if t != "null"] + if non_null_types: + prop_type = non_null_types[0] + else: + return ColumnType.STRING + + if prop_type == "array": return _get_list_column_type_from_js_property(type_item) - return TYPE_DICT.get(type_item["type"], ColumnType.STRING) + return TYPE_DICT.get(prop_type, ColumnType.STRING) return ColumnType.STRING diff --git a/utils/sync_model_systems_enhanced.py b/utils/sync_model_systems_enhanced.py new file mode 100644 index 00000000..e14e45dc --- /dev/null +++ b/utils/sync_model_systems_enhanced.py @@ -0,0 +1,411 @@ +#!/usr/bin/env python3 +""" +Enhanced model system sync with conditional enum filtering. + +This script queries syn51730943 (NF Tools Database) and generates: +1. Base enum files (CellLineModel.yaml, AnimalModel.yaml) - backward compatibility +2. Filtered enum subsets for conditional dependencies (species + category + disorder combinations) + +The filtered subsets enable the JSON schemas to provide <100 enum values per dropdown +based on user's selections in modelSystemType, modelSpecies, cellLineCategory, etc. +""" + +import os +import sys +import yaml +from typing import Dict, List, Any, Tuple +import argparse + + +def fetch_model_system_data_with_metadata(synapse_id: str = 'syn51730943') -> Tuple[List[Dict], List[Dict]]: + """ + Fetch cell lines and animal models with full metadata from NF Tools Database. + + Args: + synapse_id: Synapse table ID for NF Tools Central (default: syn51730943) + + Returns: + Tuple of (cell_lines_list, animal_models_list) with full metadata + """ + try: + import synapseclient + from synapseclient import Synapse + + syn = Synapse() + + # Try to login - anonymous access should work for public tables + try: + if os.getenv('SYNAPSE_AUTH_TOKEN'): + syn.login(authToken=os.getenv('SYNAPSE_AUTH_TOKEN'), silent=True) + except: + pass + + print(f"Fetching model system data from {synapse_id}...") + + # Query for cell lines with all relevant metadata + cell_query = """ + SELECT resourceName, rrid, description, resourceType, species, + cellLineCategory, cellLineGeneticDisorder, resourceId + FROM {table} + WHERE resourceType = 'Cell Line' + """.format(table=synapse_id) + + cell_result = syn.tableQuery(cell_query) + cell_df = cell_result.asDataFrame() + + print(f" → Retrieved {len(cell_df)} cell lines") + + # Query for animal models + animal_query = """ + SELECT resourceName, rrid, description, resourceType, species, + animalModelGeneticDisorder, resourceId + FROM {table} + WHERE resourceType = 'Animal Model' + """.format(table=synapse_id) + + animal_result = syn.tableQuery(animal_query) + animal_df = animal_result.asDataFrame() + + print(f" → Retrieved {len(animal_df)} animal models") + + # Convert DataFrames to list of dicts + cell_lines = cell_df.to_dict('records') + animal_models = animal_df.to_dict('records') + + return cell_lines, animal_models + + except ImportError: + print("Error: synapseclient not available") + sys.exit(1) + except Exception as e: + print(f"Error fetching data: {e}") + sys.exit(1) + + +def format_enum_entry_enhanced(resource: Dict[str, Any]) -> Dict: + """ + Format a model system entry for YAML enum with full metadata. + + Args: + resource: Dict with resource metadata from syn51730943 + + Returns: + Dict with formatted enum entry + """ + import pandas as pd + + name = resource.get('resourceName', '') + if not name or pd.isna(name): + return {} + + entry = {} + + # Add description if different from name + description = resource.get('description', '') + if description and not pd.isna(description) and description != name: + entry['description'] = str(description) + + # Add RRID as 'meaning' field + rrid = resource.get('rrid', '') + if rrid and not pd.isna(rrid): + entry['meaning'] = str(rrid) + + # Add source link to NF Tools Central + resource_id = resource.get('resourceId', '') + if resource_id and not pd.isna(resource_id): + entry['source'] = f"https://nf.synapse.org/Explore/Tools/DetailsPage/Details?resourceId={resource_id}" + + return {name: entry} if entry else {name: {}} + + +def generate_filtered_enum_subsets(cell_lines: List[Dict], animal_models: List[Dict]) -> Dict[str, Dict]: + """ + Generate filtered enum subsets based on species, category, and genetic disorder. + + Returns: + Dict mapping enum_name to {permissible_values: {...}} + """ + from collections import defaultdict + import pandas as pd + + print("\n" + "="*60) + print("GENERATING FILTERED ENUM SUBSETS") + print("="*60) + + # Helper to check if species list contains target + def has_species(species_list, target): + if not isinstance(species_list, list): + return False + return any(target in str(s) for s in species_list) + + # Group cell lines by species + category + disorder + cell_grouped = defaultdict(list) + + for cell in cell_lines: + species_list = cell.get('species', []) + category = cell.get('cellLineCategory', 'Unknown') + disorder_list = cell.get('cellLineGeneticDisorder', []) + + # Normalize empty/null values + if not isinstance(species_list, list) or not species_list: + species_list = ['Unknown'] + # Handle NaN/None/float values for category + if pd.isna(category) or not category or category == '' or not isinstance(category, str): + category = 'Unknown' + if not isinstance(disorder_list, list) or not disorder_list: + disorder_list = ['Unknown'] + + # Create entries for each species + for species in species_list: + # Normalize species name for file naming + species_short = species.replace(' ', '').replace('.', '') + + # For each disorder combination + for disorder in disorder_list: + disorder_short = disorder.replace(' ', '').replace('[', '').replace(']', '').replace("'", '') + + # Create key for this combination + key = (species_short, category, disorder_short) + cell_grouped[key].append(cell) + + # Group animal models by species + disorder + animal_grouped = defaultdict(list) + + for animal in animal_models: + species_list = animal.get('species', []) + disorder_list = animal.get('animalModelGeneticDisorder', []) + + if not isinstance(species_list, list) or not species_list: + species_list = ['Unknown'] + if not isinstance(disorder_list, list) or not disorder_list: + disorder_list = ['Unknown'] + + for species in species_list: + species_short = species.replace(' ', '').replace('.', '') + for disorder in disorder_list: + disorder_short = disorder.replace(' ', '').replace('[', '').replace(']', '').replace("'", '') + key = (species_short, disorder_short) + animal_grouped[key].append(animal) + + # Generate enum files for combinations with reasonable counts + enums = {} + + # Cell line enums + for (species, category, disorder), cells in cell_grouped.items(): + count = len(cells) + + # Only generate if <100 entries or if it's a major category + if count > 100 and count < 400: + # Skip - would need further filtering + continue + + # Create enum name + category_safe = category.replace(' ', '').replace('-', '') + enum_name = f"CellLine{species}{category_safe}{disorder}Enum" + + # Format entries + entries = {} + for cell in cells: + formatted = format_enum_entry_enhanced(cell) + entries.update(formatted) + + if entries: + enums[enum_name] = { + 'description': f"Cell lines: {species} + {category} + {disorder} ({count} entries)", + 'permissible_values': entries, + '_metadata': { + 'species': species, + 'category': category, + 'disorder': disorder, + 'count': count, + 'type': 'cell_line' + } + } + + # Animal model enums + for (species, disorder), animals in animal_grouped.items(): + count = len(animals) + + if count > 100: + continue # Skip if still too large + + enum_name = f"AnimalModel{species}{disorder}Enum" + + entries = {} + for animal in animals: + formatted = format_enum_entry_enhanced(animal) + entries.update(formatted) + + if entries: + enums[enum_name] = { + 'description': f"Animal models: {species} + {disorder} ({count} entries)", + 'permissible_values': entries, + '_metadata': { + 'species': species, + 'disorder': disorder, + 'count': count, + 'type': 'animal_model' + } + } + + # Print summary + print(f"\nGenerated {len(enums)} filtered enum subsets:") + for enum_name, data in sorted(enums.items(), key=lambda x: -x[1]['_metadata']['count']): + meta = data['_metadata'] + count = meta['count'] + status = '✓' if count <= 100 else f'({count} >100)' + print(f" {enum_name}: {count} entries {status}") + + return enums + + +def save_filtered_enum_files(enums: Dict[str, Dict], output_dir: str = 'modules/Sample/generated'): + """ + Save filtered enum files to disk. + + Args: + enums: Dict of enum_name -> enum_data + output_dir: Directory to save files + """ + os.makedirs(output_dir, exist_ok=True) + + print(f"\nSaving filtered enum files to {output_dir}/...") + + for enum_name, enum_data in enums.items(): + # Remove metadata before saving + meta = enum_data.pop('_metadata') + + # Create filename from enum name + filename = f"{enum_name}.yaml" + filepath = os.path.join(output_dir, filename) + + # Write file + content = { + 'enums': { + enum_name: { + 'description': enum_data['description'], + 'permissible_values': enum_data['permissible_values'] + } + } + } + + with open(filepath, 'w') as f: + f.write(f"# Auto-generated filtered enum subset\n") + f.write(f"# Type: {meta['type']}\n") + f.write(f"# Count: {meta['count']} entries\n") + if meta['type'] == 'cell_line': + f.write(f"# Filters: species={meta['species']}, category={meta['category']}, disorder={meta['disorder']}\n") + else: + f.write(f"# Filters: species={meta['species']}, disorder={meta['disorder']}\n") + f.write(f"\n") + yaml.dump(content, f, default_flow_style=False, sort_keys=False, allow_unicode=True) + + print(f" ✓ {filename}") + + +def generate_base_enums(cell_lines: List[Dict], animal_models: List[Dict]) -> Tuple[Dict, Dict]: + """ + Generate base CellLineModel and AnimalModel enums for backward compatibility. + + Returns: + Tuple of (cell_line_enum, animal_model_enum) + """ + print("\nGenerating base enum files for backward compatibility...") + + # Cell lines + cell_entries = {} + for cell in cell_lines: + formatted = format_enum_entry_enhanced(cell) + cell_entries.update(formatted) + + cell_enum = { + 'CellLineModel': { + 'permissible_values': cell_entries + } + } + + # Animal models + animal_entries = {} + for animal in animal_models: + formatted = format_enum_entry_enhanced(animal) + animal_entries.update(formatted) + + animal_enum = { + 'AnimalModel': { + 'permissible_values': animal_entries + } + } + + print(f" → CellLineModel: {len(cell_entries)} entries") + print(f" → AnimalModel: {len(animal_entries)} entries") + + return cell_enum, animal_enum + + +def save_base_enum_file(enum_data: Dict, filepath: str, enum_type: str): + """Save base enum file with header.""" + with open(filepath, 'w') as f: + f.write(f"# WARNING: This file is auto-generated from Synapse table syn51730943\n") + f.write(f"# DO NOT EDIT DIRECTLY - changes will be overwritten\n") + f.write(f"# For manual entries, use the corresponding *Manual.yaml file\n") + f.write(f"# Generated by utils/sync_model_systems_enhanced.py\n") + f.write(f"\n") + # Wrap enum_data in proper structure with correct indentation + content = {'enums': enum_data} + yaml.dump(content, f, default_flow_style=False, sort_keys=False, allow_unicode=True) + + print(f" ✓ Saved {filepath}") + + +def main(): + parser = argparse.ArgumentParser(description='Sync model systems with conditional filtering') + parser.add_argument('--synapse-id', default='syn51730943', + help='Synapse table ID (default: syn51730943 - NF Tools Database)') + parser.add_argument('--dry-run', action='store_true', + help='Show what would be done without making changes') + + args = parser.parse_args() + + print("="*60) + print("ENHANCED MODEL SYSTEM SYNC WITH CONDITIONAL FILTERING") + print("="*60) + print(f"Source: {args.synapse_id}") + print(f"Dry run: {args.dry_run}") + print() + + # Fetch data + cell_lines, animal_models = fetch_model_system_data_with_metadata(args.synapse_id) + + # Generate filtered enum subsets + filtered_enums = generate_filtered_enum_subsets(cell_lines, animal_models) + + # Generate base enums for backward compatibility + cell_enum, animal_enum = generate_base_enums(cell_lines, animal_models) + + if not args.dry_run: + # Save filtered enums + save_filtered_enum_files(filtered_enums) + + # Save base enums + save_base_enum_file(cell_enum, 'modules/Sample/CellLineModel.yaml', 'cell_line') + save_base_enum_file(animal_enum, 'modules/Sample/AnimalModel.yaml', 'animal_model') + + print("\n" + "="*60) + print("SYNC COMPLETED SUCCESSFULLY") + print("="*60) + print(f"✓ Generated {len(filtered_enums)} filtered enum subsets") + print(f"✓ Updated base enum files (CellLineModel.yaml, AnimalModel.yaml)") + print("\nNext steps:") + print(" 1. Add conditional dependencies to templates (if/then/else)") + print(" 2. Reorder template fields (filters before modelSystemName)") + print(" 3. Rebuild schemas with: make clean && make") + else: + print("\n" + "="*60) + print("DRY RUN - NO FILES MODIFIED") + print("="*60) + print(f"Would generate {len(filtered_enums)} filtered enum subsets") + print(f"Would update base enum files") + + +if __name__ == '__main__': + main()