#3586 updated PNS_neurons.csv

[RiveraAndrea83]

updated PNS_neurons.csv table

[dosumis]

#gogoeditdiff

[github-actions]

Here's a diff of how these changes impact the classified ontology (on -base file):

Ontology comparison

Left

• Ontology IRI: http://purl.obolibrary.org/obo/cl/cl-base.owl
• Version IRI: http://purl.obolibrary.org/obo/cl/releases/2026-03-13/cl-base.owl
• Loaded from: file:/__w/cell-ontology/cell-ontology/src/ontology/cl-base-master.owl/cl-base.owl

Right

• Ontology IRI: http://purl.obolibrary.org/obo/cl/cl-base.owl
• Version IRI: http://purl.obolibrary.org/obo/cl/releases/2026-03-13/cl-base.owl
• Loaded from: file:/__w/cell-ontology/cell-ontology/src/ontology/cl-base-pr.owl/cl-base.owl

Ontology imports

Ontology annotations

PR_000002097 http://purl.obolibrary.org/obo/PR_000002097

Added

• Class: PR_000002097

PR_000002104 http://purl.obolibrary.org/obo/PR_000002104

Added

• Class: PR_000002104

PR_000004968 http://purl.obolibrary.org/obo/PR_000004968

Added

• Class: PR_000004968

PR_000004984 http://purl.obolibrary.org/obo/PR_000004984

Removed

• Class: PR_000004984

PR_000006897 http://purl.obolibrary.org/obo/PR_000006897

Added

• Class: PR_000006897

PR_000013041 http://purl.obolibrary.org/obo/PR_000013041

Added

• Class: PR_000013041

PR_000013289 http://purl.obolibrary.org/obo/PR_000013289

Added

• Class: PR_000013289

PR_000013895 http://purl.obolibrary.org/obo/PR_000013895

Added

• Class: PR_000013895

PR_000016003 http://purl.obolibrary.org/obo/PR_000016003

Added

• Class: PR_000016003

PR_000032708 http://purl.obolibrary.org/obo/PR_000032708

Added

• Class: PR_000032708

UBERON_0002834 http://purl.obolibrary.org/obo/UBERON_0002834

Added

• Class: UBERON_0002834

UBERON_0002835 http://purl.obolibrary.org/obo/UBERON_0002835

Added

• Class: UBERON_0002835

UBERON_0002836 http://purl.obolibrary.org/obo/UBERON_0002836

Added

• Class: UBERON_0002836

UBERON_0002837 http://purl.obolibrary.org/obo/UBERON_0002837

Added

• Class: UBERON_0002837

UBERON_0014463 http://purl.obolibrary.org/obo/UBERON_0014463

Added

• Class: UBERON_0014463

celiac ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4033130

Added

• celiac ganglion CGRP neuron hasExactSynonym "CG CGRP neuron"

celiac ganglion PHI neuron http://purl.obolibrary.org/obo/CL_4033129

Added

• celiac ganglion PHI neuron hasExactSynonym "CG PHI neuron"

• celiac ganglion PHI neuron SubClassOf RO_0002292 some PR_000017299

celiac ganglion SOM neuron http://purl.obolibrary.org/obo/CL_4033132

Added

• celiac ganglion SOM neuron hasExactSynonym "CG SOM neuron"

celiac ganglion SOM/CGRP neuron http://purl.obolibrary.org/obo/CL_4033133

Added

• celiac ganglion SOM/CGRP neuron hasExactSynonym "CG SOM/CGRP neuron"

celiac ganglion SP neuron http://purl.obolibrary.org/obo/CL_4033131

Added

• celiac ganglion SP neuron hasExactSynonym "CG SP neuron"

• celiac ganglion SP neuron SubClassOf RO_0002292 some PR_000016003

celiac ganglion VIP neuron http://purl.obolibrary.org/obo/CL_4033128

Added

• celiac ganglion VIP neuron hasExactSynonym "CG VIP neuron"

cervical dorsal root ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4079000

Added

• Class: cervical dorsal root ganglion CGRP neuron

• cervical dorsal root ganglion CGRP neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion CGRP neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion CGRP neuron hasRelatedSynonym "peptidergic nociceptor"

• cervical dorsal root ganglion CGRP neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the cervical dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

  • hasDbXref "PMID:29229553"

• cervical dorsal root ganglion CGRP neuron label "cervical dorsal root ganglion CGRP neuron"

• cervical dorsal root ganglion CGRP neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion CGRP neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion CGRP neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion CGRP neuron SubClassOf RO_0002292 some PR_000027226

cervical dorsal root ganglion Nav1.7 neuron http://purl.obolibrary.org/obo/CL_4079002

Added

• Class: cervical dorsal root ganglion Nav1.7 neuron

• cervical dorsal root ganglion Nav1.7 neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion Nav1.7 neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion Nav1.7 neuron IAO_0000115 "A nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• cervical dorsal root ganglion Nav1.7 neuron label "cervical dorsal root ganglion Nav1.7 neuron"

• cervical dorsal root ganglion Nav1.7 neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion Nav1.7 neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002292 some PR_000002104

cervical dorsal root ganglion Nav1.9 neuron http://purl.obolibrary.org/obo/CL_4079003

Added

• Class: cervical dorsal root ganglion Nav1.9 neuron

• cervical dorsal root ganglion Nav1.9 neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion Nav1.9 neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion Nav1.9 neuron IAO_0000115 "A nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1016/S0166-2236(02)02150-1"

  • hasDbXref "PMID:29229553"

• cervical dorsal root ganglion Nav1.9 neuron label "cervical dorsal root ganglion Nav1.9 neuron"

• cervical dorsal root ganglion Nav1.9 neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion Nav1.9 neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002292 some PR_000002097

cervical dorsal root ganglion Piezo2 neuron http://purl.obolibrary.org/obo/CL_4079005

Added

• Class: cervical dorsal root ganglion Piezo2 neuron

• cervical dorsal root ganglion Piezo2 neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion Piezo2 neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion Piezo2 neuron hasRelatedSynonym "mechanosensitive DRG neuron"

• cervical dorsal root ganglion Piezo2 neuron IAO_0000115 "A mechanosensitive sensory neuron whose soma is located in the cervical dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• cervical dorsal root ganglion Piezo2 neuron label "cervical dorsal root ganglion Piezo2 neuron"

• cervical dorsal root ganglion Piezo2 neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion Piezo2 neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion Piezo2 neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion Piezo2 neuron SubClassOf RO_0002292 some PR_000032708

cervical dorsal root ganglion RET neuron http://purl.obolibrary.org/obo/CL_4079006

Added

• Class: cervical dorsal root ganglion RET neuron

• cervical dorsal root ganglion RET neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion RET neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion RET neuron hasRelatedSynonym "non-peptidergic nociceptor"

• cervical dorsal root ganglion RET neuron IAO_0000115 "A non-peptidergic nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• cervical dorsal root ganglion RET neuron label "cervical dorsal root ganglion RET neuron"

• cervical dorsal root ganglion RET neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion RET neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion RET neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion RET neuron SubClassOf RO_0002292 some PR_000013895

cervical dorsal root ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4079008

Added

• Class: cervical dorsal root ganglion TRPV1 neuron

• cervical dorsal root ganglion TRPV1 neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion TRPV1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion TRPV1 neuron hasRelatedSynonym "capsaicin-sensitive nociceptor"

• cervical dorsal root ganglion TRPV1 neuron IAO_0000115 "A polymodal nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• cervical dorsal root ganglion TRPV1 neuron label "cervical dorsal root ganglion TRPV1 neuron"

• cervical dorsal root ganglion TRPV1 neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion TRPV1 neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion TRPV1 neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion TRPV1 neuron SubClassOf RO_0002292 some PR_000001065

cervical dorsal root ganglion endothelin-1 neuron http://purl.obolibrary.org/obo/CL_4079001

Added

• Class: cervical dorsal root ganglion endothelin-1 neuron

• cervical dorsal root ganglion endothelin-1 neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion endothelin-1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion endothelin-1 neuron hasExactSynonym "cervical dorsal root ganglion Endothelin 1 neuron"

• cervical dorsal root ganglion endothelin-1 neuron hasRelatedSynonym "EDN1 neuron"

• cervical dorsal root ganglion endothelin-1 neuron IAO_0000115 "A sensory neuron whose soma is located in the cervical dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."

  • hasDbXref "10.1073/pnas.86.19.7634"

• cervical dorsal root ganglion endothelin-1 neuron label "cervical dorsal root ganglion endothelin-1 neuron"

• cervical dorsal root ganglion endothelin-1 neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion endothelin-1 neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002292 some PR_000006897

cervical dorsal root ganglion peripherin neuron http://purl.obolibrary.org/obo/CL_4079004

Added

• Class: cervical dorsal root ganglion peripherin neuron

• cervical dorsal root ganglion peripherin neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion peripherin neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion peripherin neuron hasExactSynonym "cervical dorsal root ganglion Peripherin neuron"

• cervical dorsal root ganglion peripherin neuron hasRelatedSynonym "C-fiber neuron"

• cervical dorsal root ganglion peripherin neuron IAO_0000115 "A small-diameter sensory neuron whose soma is located in the cervical dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:31293388"

• cervical dorsal root ganglion peripherin neuron label "cervical dorsal root ganglion peripherin neuron"

• cervical dorsal root ganglion peripherin neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion peripherin neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion peripherin neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion peripherin neuron SubClassOf RO_0002292 some PR_000013289

cervical dorsal root ganglion substance P neuron http://purl.obolibrary.org/obo/CL_4079007

Added

• Class: cervical dorsal root ganglion substance P neuron

• cervical dorsal root ganglion substance P neuron contributor 0000-0001-6677-8489

• cervical dorsal root ganglion substance P neuron date "2026-03-13T11:13:54Z"^^dateTime

• cervical dorsal root ganglion substance P neuron hasExactSynonym "cervical dorsal root ganglion SP neuron"

• cervical dorsal root ganglion substance P neuron hasRelatedSynonym "SP neuron"

• cervical dorsal root ganglion substance P neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the cervical dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

• cervical dorsal root ganglion substance P neuron label "cervical dorsal root ganglion substance P neuron"

• cervical dorsal root ganglion substance P neuron SubClassOf BFO_0000002

• cervical dorsal root ganglion substance P neuron SubClassOf sensory neuron of dorsal root ganglion

• cervical dorsal root ganglion substance P neuron SubClassOf RO_0002100 some UBERON_0002834

• cervical dorsal root ganglion substance P neuron SubClassOf RO_0002292 some PR_000016003

cervicothoracic ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033114

Added

• cervicothoracic ganglion TH neuron hasExactSynonym "stellate ganglion TH neuron"

cervicothoracic ganglion TH/NPY neuron http://purl.obolibrary.org/obo/CL_4033115

Added

• cervicothoracic ganglion TH/NPY neuron hasExactSynonym "stellate ganglion TH/NPY neuron"

cervicothoracic ganglion VAChT neuron http://purl.obolibrary.org/obo/CL_4033117

Added

• cervicothoracic ganglion VAChT neuron hasExactSynonym "stellate ganglion VAChT neuron"

cervicothoracic ganglion VIP neuron http://purl.obolibrary.org/obo/CL_4033116

Added

• cervicothoracic ganglion VIP neuron hasExactSynonym "stellate ganglion VIP neuron"

cervicothoracic ganglion enkephalin neuron http://purl.obolibrary.org/obo/CL_4033113

Added

• cervicothoracic ganglion enkephalin neuron hasExactSynonym "stellate ganglion enkephalin neuron"

ciliary ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033140

Removed

• ciliary ganglion TH neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "doi:10.1016/0006-8993(95)00299-6"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• ciliary ganglion TH neuron SubClassOf autonomic neuron

Added

• ciliary ganglion TH neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the ciliary ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "doi:10.1016/0006-8993(95)00299-6"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• ciliary ganglion TH neuron SubClassOf parasympathetic neuron

ciliary ganglion VIP/PHI neuron http://purl.obolibrary.org/obo/CL_4033139

Removed

• ciliary ganglion VIP/PHI neuron date "2025-07-22T09:18:18Z"^^dateTime

• ciliary ganglion VIP/PHI neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the ciliary ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• ciliary ganglion VIP/PHI neuron SubClassOf autonomic neuron

Added

• ciliary ganglion VIP/PHI neuron date "2026-03-13T11:13:54Z"^^dateTime

• ciliary ganglion VIP/PHI neuron hasExactSynonym "ciliary ganglion VIP-PHI neuron"

• ciliary ganglion VIP/PHI neuron IAO_0000115 "A parasympathetic postganglionic neuron whose soma is located in the ciliary ganglion and that co-expresses vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI, both encoded by the VIP gene). This neuron provides parasympathetic innervation to the eye, contributing to regulation of pupillary constriction and ciliary muscle accommodation. It has been identified in human ciliary ganglia by immunohistochemistry (Kiyokawa et al. 2012, PMID:22095632). VIP/PHI co-expression distinguishes this subpopulation from other cholinergic parasympathetic neurons in the ciliary ganglion and is characteristic of a subset of cranial parasympathetic neurons in humans and other mammals."

  • hasDbXref "10.1002/ar.21516"

• ciliary ganglion VIP/PHI neuron SubClassOf parasympathetic neuron

dorsal root ganglion BRN3A neuron http://purl.obolibrary.org/obo/CL_4033175

Added

• Class: dorsal root ganglion BRN3A neuron

• dorsal root ganglion BRN3A neuron contributor 0000-0001-6677-8489

• dorsal root ganglion BRN3A neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion BRN3A neuron hasExactSynonym "DRG BRN3A neuron"

• dorsal root ganglion BRN3A neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the pan-sensory transcription factor POU domain, class 4, transcription factor 1 (BRN3A/POU4F1). In humans, BRN3A is expressed by approximately 98% of DRG neurons and serves as a broad marker for the sensory neuron population."

  • hasDbXref "PMID:29229553"

• dorsal root ganglion BRN3A neuron label "dorsal root ganglion BRN3A neuron"

• dorsal root ganglion BRN3A neuron SubClassOf BFO_0000002

• dorsal root ganglion BRN3A neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion BRN3A neuron SubClassOf RO_0002292 some PR_000013041

dorsal root ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4033176

Added

• Class: dorsal root ganglion CGRP neuron

• dorsal root ganglion CGRP neuron contributor 0000-0001-6677-8489

• dorsal root ganglion CGRP neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion CGRP neuron hasExactSynonym "DRG CGRP neuron"

• dorsal root ganglion CGRP neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker calcitonin gene-related peptide (CGRP). This peptidergic nociceptor subpopulation is involved in neurogenic inflammation and pain signaling."

  • hasDbXref "PMID:31293388"

  • hasDbXref "PMID:10686397"

  • hasDbXref "PMID:29229553"

• dorsal root ganglion CGRP neuron label "dorsal root ganglion CGRP neuron"

• dorsal root ganglion CGRP neuron SubClassOf BFO_0000002

• dorsal root ganglion CGRP neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion CGRP neuron SubClassOf RO_0002292 some PR_000027226

dorsal root ganglion EDN1 neuron http://purl.obolibrary.org/obo/CL_4033177

Added

• Class: dorsal root ganglion EDN1 neuron

• dorsal root ganglion EDN1 neuron contributor 0000-0001-6677-8489

• dorsal root ganglion EDN1 neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion EDN1 neuron hasExactSynonym "DRG EDN1 neuron"

• dorsal root ganglion EDN1 neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker endothelin-1 (EDN1). Endothelin signaling in DRG neurons has been demonstrated in rat tissue."

  • hasDbXref "PMID:2678100"

• dorsal root ganglion EDN1 neuron label "dorsal root ganglion EDN1 neuron"

• dorsal root ganglion EDN1 neuron SubClassOf BFO_0000002

• dorsal root ganglion EDN1 neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion EDN1 neuron SubClassOf RO_0002292 some PR_000006897

dorsal root ganglion Nav1.7 neuron http://purl.obolibrary.org/obo/CL_4033178

Added

• Class: dorsal root ganglion Nav1.7 neuron

• dorsal root ganglion Nav1.7 neuron contributor 0000-0001-6677-8489

• dorsal root ganglion Nav1.7 neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion Nav1.7 neuron hasExactSynonym "DRG Nav1.7 neuron"

• dorsal root ganglion Nav1.7 neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker sodium channel protein type 9 subunit alpha (Nav1.7/SCN9A). Nav1.7 accounts for approximately 50% of total sodium channel expression in human DRG and is present in 54-57% of TrkA-positive nociceptors."

  • hasDbXref "PMID:28853927"

  • hasDbXref "PMID:29229553"

• dorsal root ganglion Nav1.7 neuron label "dorsal root ganglion Nav1.7 neuron"

• dorsal root ganglion Nav1.7 neuron SubClassOf BFO_0000002

• dorsal root ganglion Nav1.7 neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002292 some PR_000002104

dorsal root ganglion Nav1.9 neuron http://purl.obolibrary.org/obo/CL_4033179

Added

• Class: dorsal root ganglion Nav1.9 neuron

• dorsal root ganglion Nav1.9 neuron contributor 0000-0001-6677-8489

• dorsal root ganglion Nav1.9 neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion Nav1.9 neuron hasExactSynonym "DRG Nav1.9 neuron"

• dorsal root ganglion Nav1.9 neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker sodium channel protein type 11 subunit alpha (Nav1.9/SCN11A). Nav1.9 is present in approximately 26% of TrkA-positive human DRG neurons and defines a nociceptor subpopulation."

  • hasDbXref "PMID:11972962"

  • hasDbXref "PMID:29229553"

• dorsal root ganglion Nav1.9 neuron label "dorsal root ganglion Nav1.9 neuron"

• dorsal root ganglion Nav1.9 neuron SubClassOf BFO_0000002

• dorsal root ganglion Nav1.9 neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002292 some PR_000002097

dorsal root ganglion Piezo2 neuron http://purl.obolibrary.org/obo/CL_4033181

Added

• Class: dorsal root ganglion Piezo2 neuron

• dorsal root ganglion Piezo2 neuron contributor 0000-0001-6677-8489

• dorsal root ganglion Piezo2 neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion Piezo2 neuron hasExactSynonym "DRG Piezo2 neuron"

• dorsal root ganglion Piezo2 neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker piezo-type mechanosensitive ion channel component 2 (Piezo2). Piezo2 is the primary mechanotransduction channel and is present in approximately 35% of TrkA-positive human DRG neurons."

  • hasDbXref "PMID:29229553"

• dorsal root ganglion Piezo2 neuron label "dorsal root ganglion Piezo2 neuron"

• dorsal root ganglion Piezo2 neuron SubClassOf BFO_0000002

• dorsal root ganglion Piezo2 neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion Piezo2 neuron SubClassOf RO_0002292 some PR_000032708

dorsal root ganglion RET neuron http://purl.obolibrary.org/obo/CL_4033182

Added

• Class: dorsal root ganglion RET neuron

• dorsal root ganglion RET neuron contributor 0000-0001-6677-8489

• dorsal root ganglion RET neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion RET neuron hasExactSynonym "DRG RET neuron"

• dorsal root ganglion RET neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker proto-oncogene tyrosine-protein kinase receptor Ret (RET). RET is present in approximately 46% of TrkA-positive human DRG neurons and marks the non-peptidergic nociceptor population."

  • hasDbXref "PMID:29229553"

• dorsal root ganglion RET neuron label "dorsal root ganglion RET neuron"

• dorsal root ganglion RET neuron SubClassOf BFO_0000002

• dorsal root ganglion RET neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion RET neuron SubClassOf RO_0002292 some PR_000013895

dorsal root ganglion SP neuron http://purl.obolibrary.org/obo/CL_4033183

Added

• Class: dorsal root ganglion SP neuron

• dorsal root ganglion SP neuron contributor 0000-0001-6677-8489

• dorsal root ganglion SP neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion SP neuron hasExactSynonym "DRG SP neuron"

• dorsal root ganglion SP neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker protachykinin-1 (substance P). This peptidergic nociceptor subpopulation is involved in pain signaling and neurogenic inflammation."

  • hasDbXref "PMID:31293388"

  • hasDbXref "PMID:10686397"

• dorsal root ganglion SP neuron label "dorsal root ganglion SP neuron"

• dorsal root ganglion SP neuron SubClassOf BFO_0000002

• dorsal root ganglion SP neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion SP neuron SubClassOf RO_0002292 some PR_000016003

dorsal root ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4033184

Added

• Class: dorsal root ganglion TRPV1 neuron

• dorsal root ganglion TRPV1 neuron contributor 0000-0001-6677-8489

• dorsal root ganglion TRPV1 neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion TRPV1 neuron hasExactSynonym "DRG TRPV1 neuron"

• dorsal root ganglion TRPV1 neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker transient receptor potential cation channel subfamily V member 1 (TRPV1). TRPV1 is the canonical heat and capsaicin nociceptor marker and is present in approximately 54% of TrkA-positive human DRG neurons."

  • hasDbXref "PMID:28853927"

  • hasDbXref "PMID:29229553"

• dorsal root ganglion TRPV1 neuron label "dorsal root ganglion TRPV1 neuron"

• dorsal root ganglion TRPV1 neuron SubClassOf BFO_0000002

• dorsal root ganglion TRPV1 neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion TRPV1 neuron SubClassOf RO_0002292 some PR_000001065

dorsal root ganglion peripherin neuron http://purl.obolibrary.org/obo/CL_4033180

Added

• Class: dorsal root ganglion peripherin neuron

• dorsal root ganglion peripherin neuron contributor 0000-0001-6677-8489

• dorsal root ganglion peripherin neuron date "2026-03-05T00:00:00Z"^^dateTime

• dorsal root ganglion peripherin neuron hasExactSynonym "DRG peripherin neuron"

• dorsal root ganglion peripherin neuron IAO_0000115 "A sensory neuron that has the soma located in the dorsal root ganglion and expresses the intermediate filament protein peripherin (PRPH). Peripherin marks small-diameter unmyelinated C-fiber neurons in the DRG."

  • hasDbXref "PMID:28853927"

  • hasDbXref "PMID:31293388"

• dorsal root ganglion peripherin neuron label "dorsal root ganglion peripherin neuron"

• dorsal root ganglion peripherin neuron SubClassOf BFO_0000002

• dorsal root ganglion peripherin neuron SubClassOf sensory neuron of dorsal root ganglion

• dorsal root ganglion peripherin neuron SubClassOf RO_0002292 some PR_000013289

inferior mesenteric ganglion SP neuron http://purl.obolibrary.org/obo/CL_4033136

Added

• inferior mesenteric ganglion SP neuron hasExactSynonym "IMG SP neuron"

• inferior mesenteric ganglion SP neuron SubClassOf RO_0002292 some PR_000016003

inferior mesenteric ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033135

Added

• inferior mesenteric ganglion TH neuron hasExactSynonym "IMG TH neuron"

intrinsic cardiac ganglion TH neuron http://purl.obolibrary.org/obo/CL_4079010

Added

• Class: intrinsic cardiac ganglion TH neuron

• intrinsic cardiac ganglion TH neuron contributor 0000-0001-6677-8489

• intrinsic cardiac ganglion TH neuron date "2026-03-13T11:13:54Z"^^dateTime

• intrinsic cardiac ganglion TH neuron hasRelatedSynonym "catecholaminergic intrinsic cardiac neuron"

• intrinsic cardiac ganglion TH neuron IAO_0000115 "A catecholaminergic neuron whose soma is located in an intrinsic cardiac ganglion and that expresses tyrosine hydroxylase (TH, encoded by TH), the rate-limiting enzyme in catecholamine biosynthesis. This neuron constitutes a minor subpopulation within the predominantly cholinergic parasympathetic intrinsic cardiac nervous system, identified in adult human cardiac ganglia by immunohistochemistry (Singh et al. 1999, PMID:9918529; Kawano et al. 2003, DOI:10.1007/s003800300005). It participates in local cardiac autonomic regulation, including modulation of heart rate and contractility. Its catecholaminergic phenotype distinguishes it from the majority cholinergic neurons of the same ganglia."

  • hasDbXref "10.1007/s003800300005"

  • hasDbXref "PMID:9918529"

• intrinsic cardiac ganglion TH neuron label "intrinsic cardiac ganglion TH neuron"

• intrinsic cardiac ganglion TH neuron SubClassOf autonomic neuron

• intrinsic cardiac ganglion TH neuron SubClassOf RO_0002100 some UBERON_0014463

• intrinsic cardiac ganglion TH neuron SubClassOf RO_0002292 some PR_000016301

jugular ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4033155

Added

• jugular ganglion CGRP neuron hasExactSynonym "superior vagus X ganglion CGRP neuron"

jugular ganglion SP neuron http://purl.obolibrary.org/obo/CL_4033154

Added

• jugular ganglion SP neuron hasExactSynonym "superior vagus X ganglion SP neuron"

• jugular ganglion SP neuron SubClassOf RO_0002292 some PR_000016003

jugular ganglion SPARCL1 neuron http://purl.obolibrary.org/obo/CL_4033156

Added

• jugular ganglion SPARCL1 neuron hasExactSynonym "superior vagus X ganglion SPARCL1 neuron"

jugular ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4033152

Added

• jugular ganglion TRPV1 neuron hasExactSynonym "superior vagus X ganglion TRPV1 neuron"

jugular ganglion TRPV2 neuron http://purl.obolibrary.org/obo/CL_4033153

Added

• jugular ganglion TRPV2 neuron hasExactSynonym "superior vagus X ganglion TRPV2 neuron"

lower airway ganglion ChAT/VIP neuron http://purl.obolibrary.org/obo/CL_4033127

Removed

• lower airway ganglion ChAT/VIP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the lower airway ganglion and expresses the marker choline O-acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1111/j.1749-6632.1996.tb17547.x"

• lower airway ganglion ChAT/VIP neuron SubClassOf autonomic neuron

Added

• lower airway ganglion ChAT/VIP neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the lower airway ganglion and expresses the marker choline O-acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1111/j.1749-6632.1996.tb17547.x"

• lower airway ganglion ChAT/VIP neuron SubClassOf parasympathetic neuron

lumbar dorsal root ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4079011

Added

• Class: lumbar dorsal root ganglion CGRP neuron

• lumbar dorsal root ganglion CGRP neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion CGRP neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion CGRP neuron hasRelatedSynonym "peptidergic nociceptor"

• lumbar dorsal root ganglion CGRP neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the lumbar dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

  • hasDbXref "PMID:29229553"

• lumbar dorsal root ganglion CGRP neuron label "lumbar dorsal root ganglion CGRP neuron"

• lumbar dorsal root ganglion CGRP neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion CGRP neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion CGRP neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion CGRP neuron SubClassOf RO_0002292 some PR_000027226

lumbar dorsal root ganglion Nav1.7 neuron http://purl.obolibrary.org/obo/CL_4079013

Added

• Class: lumbar dorsal root ganglion Nav1.7 neuron

• lumbar dorsal root ganglion Nav1.7 neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion Nav1.7 neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion Nav1.7 neuron IAO_0000115 "A nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• lumbar dorsal root ganglion Nav1.7 neuron label "lumbar dorsal root ganglion Nav1.7 neuron"

• lumbar dorsal root ganglion Nav1.7 neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion Nav1.7 neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002292 some PR_000002104

lumbar dorsal root ganglion Nav1.9 neuron http://purl.obolibrary.org/obo/CL_4079014

Added

• Class: lumbar dorsal root ganglion Nav1.9 neuron

• lumbar dorsal root ganglion Nav1.9 neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion Nav1.9 neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion Nav1.9 neuron IAO_0000115 "A nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1016/S0166-2236(02)02150-1"

  • hasDbXref "PMID:29229553"

• lumbar dorsal root ganglion Nav1.9 neuron label "lumbar dorsal root ganglion Nav1.9 neuron"

• lumbar dorsal root ganglion Nav1.9 neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion Nav1.9 neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002292 some PR_000002097

lumbar dorsal root ganglion Piezo2 neuron http://purl.obolibrary.org/obo/CL_4079016

Added

• Class: lumbar dorsal root ganglion Piezo2 neuron

• lumbar dorsal root ganglion Piezo2 neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion Piezo2 neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion Piezo2 neuron hasRelatedSynonym "mechanosensitive DRG neuron"

• lumbar dorsal root ganglion Piezo2 neuron IAO_0000115 "A mechanosensitive sensory neuron whose soma is located in the lumbar dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• lumbar dorsal root ganglion Piezo2 neuron label "lumbar dorsal root ganglion Piezo2 neuron"

• lumbar dorsal root ganglion Piezo2 neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion Piezo2 neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion Piezo2 neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion Piezo2 neuron SubClassOf RO_0002292 some PR_000032708

lumbar dorsal root ganglion RET neuron http://purl.obolibrary.org/obo/CL_4079017

Added

• Class: lumbar dorsal root ganglion RET neuron

• lumbar dorsal root ganglion RET neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion RET neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion RET neuron hasRelatedSynonym "non-peptidergic nociceptor"

• lumbar dorsal root ganglion RET neuron IAO_0000115 "A non-peptidergic nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• lumbar dorsal root ganglion RET neuron label "lumbar dorsal root ganglion RET neuron"

• lumbar dorsal root ganglion RET neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion RET neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion RET neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion RET neuron SubClassOf RO_0002292 some PR_000013895

lumbar dorsal root ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4079019

Added

• Class: lumbar dorsal root ganglion TRPV1 neuron

• lumbar dorsal root ganglion TRPV1 neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion TRPV1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion TRPV1 neuron hasRelatedSynonym "capsaicin-sensitive nociceptor"

• lumbar dorsal root ganglion TRPV1 neuron IAO_0000115 "A polymodal nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• lumbar dorsal root ganglion TRPV1 neuron label "lumbar dorsal root ganglion TRPV1 neuron"

• lumbar dorsal root ganglion TRPV1 neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion TRPV1 neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion TRPV1 neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion TRPV1 neuron SubClassOf RO_0002292 some PR_000001065

lumbar dorsal root ganglion endothelin-1 neuron http://purl.obolibrary.org/obo/CL_4079012

Added

• Class: lumbar dorsal root ganglion endothelin-1 neuron

• lumbar dorsal root ganglion endothelin-1 neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion endothelin-1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion endothelin-1 neuron hasExactSynonym "lumbar dorsal root ganglion Endothelin 1 neuron"

• lumbar dorsal root ganglion endothelin-1 neuron hasRelatedSynonym "EDN1 neuron"

• lumbar dorsal root ganglion endothelin-1 neuron IAO_0000115 "A sensory neuron whose soma is located in the lumbar dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."

  • hasDbXref "10.1073/pnas.86.19.7634"

• lumbar dorsal root ganglion endothelin-1 neuron label "lumbar dorsal root ganglion endothelin-1 neuron"

• lumbar dorsal root ganglion endothelin-1 neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion endothelin-1 neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002292 some PR_000006897

lumbar dorsal root ganglion peripherin neuron http://purl.obolibrary.org/obo/CL_4079015

Added

• Class: lumbar dorsal root ganglion peripherin neuron

• lumbar dorsal root ganglion peripherin neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion peripherin neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion peripherin neuron hasExactSynonym "lumbar dorsal root ganglion Peripherin neuron"

• lumbar dorsal root ganglion peripherin neuron hasRelatedSynonym "C-fiber neuron"

• lumbar dorsal root ganglion peripherin neuron IAO_0000115 "A small-diameter sensory neuron whose soma is located in the lumbar dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:31293388"

• lumbar dorsal root ganglion peripherin neuron label "lumbar dorsal root ganglion peripherin neuron"

• lumbar dorsal root ganglion peripherin neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion peripherin neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion peripherin neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion peripherin neuron SubClassOf RO_0002292 some PR_000013289

lumbar dorsal root ganglion substance P neuron http://purl.obolibrary.org/obo/CL_4079018

Added

• Class: lumbar dorsal root ganglion substance P neuron

• lumbar dorsal root ganglion substance P neuron contributor 0000-0001-6677-8489

• lumbar dorsal root ganglion substance P neuron date "2026-03-13T11:13:54Z"^^dateTime

• lumbar dorsal root ganglion substance P neuron hasExactSynonym "lumbar dorsal root ganglion SP neuron"

• lumbar dorsal root ganglion substance P neuron hasRelatedSynonym "SP neuron"

• lumbar dorsal root ganglion substance P neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the lumbar dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

• lumbar dorsal root ganglion substance P neuron label "lumbar dorsal root ganglion substance P neuron"

• lumbar dorsal root ganglion substance P neuron SubClassOf BFO_0000002

• lumbar dorsal root ganglion substance P neuron SubClassOf sensory neuron of dorsal root ganglion

• lumbar dorsal root ganglion substance P neuron SubClassOf RO_0002100 some UBERON_0002836

• lumbar dorsal root ganglion substance P neuron SubClassOf RO_0002292 some PR_000016003

middle cervical ganglion DBH neuron http://purl.obolibrary.org/obo/CL_4033108

Added

• middle cervical ganglion DBH neuron hasExactSynonym "MCG DBH neuron"

middle cervical ganglion NPY neuron http://purl.obolibrary.org/obo/CL_4033111

Added

• middle cervical ganglion NPY neuron hasExactSynonym "MCG NPY neuron"

middle cervical ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033109

Added

• middle cervical ganglion TH neuron hasExactSynonym "MCG TH neuron"

middle cervical ganglion TH/NPY neuron http://purl.obolibrary.org/obo/CL_4033110

Added

• middle cervical ganglion TH/NPY neuron hasExactSynonym "MCG TH/NPY neuron"

middle cervical ganglion VIP neuron http://purl.obolibrary.org/obo/CL_4033112

Added

• middle cervical ganglion VIP neuron hasExactSynonym "MCG VIP neuron"

myenteric ganglion of small intestine ChAT neuron http://purl.obolibrary.org/obo/CL_4033160

Removed

• myenteric ganglion of small intestine ChAT neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline O-acetyltransferase (ChAT)."

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/j.jcmgh.2023.06.010"

Added

• myenteric ganglion of small intestine ChAT neuron hasRelatedSynonym "cholinergic myenteric neuron of small intestine"

• myenteric ganglion of small intestine ChAT neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline O-acetyltransferase (ChAT)."

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/j.jcmgh.2023.06.010"

myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron http://purl.obolibrary.org/obo/CL_4033165

Removed

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline acetyltransferase (ChAT), calreticulin (CALR), somatostatin (SOM), and substance P (SP)."

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "doi:10.1007/s00418-007-0335-1"

  • hasDbXref "FBC:Autogenerated"

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron SubClassOf RO_0002292 some PR_000004984

Added

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron hasRelatedSynonym "Dogiel type II neuron of small intestinal myenteric ganglion"

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron hasRelatedSynonym "myenteric IPAN of small intestine"

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker choline acetyltransferase (ChAT), calretinin (CALR), somatostatin (SOM), and substance P (SP)."

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "doi:10.1007/s00418-007-0335-1"

  • hasDbXref "FBC:Autogenerated"

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron SubClassOf RO_0002292 some PR_000004968

• myenteric ganglion of small intestine ChAT/CALR/SOM/SP neuron SubClassOf RO_0002292 some PR_000016003

myenteric ganglion of small intestine VIP neuron http://purl.obolibrary.org/obo/CL_4033162

Removed

• myenteric ganglion of small intestine VIP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/j.jcmgh.2023.06.010"

Added

• myenteric ganglion of small intestine VIP neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/j.jcmgh.2023.06.010"

myenteric ganglion of small intestine VIP/GAL neuron http://purl.obolibrary.org/obo/CL_4033166

Removed

• myenteric ganglion of small intestine VIP/GAL neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP) and galanin (GAL)."

  • hasDbXref "doi:10.1159/000320542"

  • hasDbXref "FBC:Autogenerated"

Added

• myenteric ganglion of small intestine VIP/GAL neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker vasoactive intestinal peptide (VIP) and galanin (GAL)."

  • hasDbXref "doi:10.1159/000320542"

  • hasDbXref "FBC:Autogenerated"

myenteric ganglion of small intestine nNOS neuron http://purl.obolibrary.org/obo/CL_4033161

Removed

• myenteric ganglion of small intestine nNOS neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "doi:10.1159/000320542"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/j.jcmgh.2023.06.010"

  • hasDbXref "doi:10.1007/s00418-021-02002-y "

Added

• myenteric ganglion of small intestine nNOS neuron hasRelatedSynonym "nitrergic myenteric neuron of small intestine"

• myenteric ganglion of small intestine nNOS neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "doi:10.1159/000320542"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/j.jcmgh.2023.06.010"

  • hasDbXref "doi:10.1007/s00418-021-02002-y "

myenteric ganglion of small intestine nNOS/ChAT neuron http://purl.obolibrary.org/obo/CL_4033164

Removed

• myenteric ganglion of small intestine nNOS/ChAT neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and choline O-acetyltransferase (ChAT)."

  • hasDbXref "doi:10.1007/s00441-009-0852-4"

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "FBC:Autogenerated"

Added

• myenteric ganglion of small intestine nNOS/ChAT neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and choline O-acetyltransferase (ChAT)."

  • hasDbXref "doi:10.1007/s00441-009-0852-4"

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "FBC:Autogenerated"

myenteric ganglion of small intestine nNOS/VIP neuron http://purl.obolibrary.org/obo/CL_4033163

Removed

• myenteric ganglion of small intestine nNOS/VIP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and vasoactive intestinal peptide (VIP)."

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "doi:10.1159/000320542"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "10.1007/s00418-005-0107-8"

Added

• myenteric ganglion of small intestine nNOS/VIP neuron hasRelatedSynonym "spiny type I neuron of small intestinal myenteric ganglion"

• myenteric ganglion of small intestine nNOS/VIP neuron IAO_0000115 "An enteric neuron that has the soma located in the myenteric ganglion of the small intestine and expresses the marker neuronal nitric oxide synthase 1 (nNOS) and vasoactive intestinal peptide (VIP)."

  • hasDbXref "doi:10.1007/s00418-021-02002-y"

  • hasDbXref "doi:10.1159/000320542"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "10.1007/s00418-005-0107-8"

nodose ganglion P2X3 neuron http://purl.obolibrary.org/obo/CL_4033149

Added

• nodose ganglion P2X3 neuron hasExactSynonym "inferior vagus X ganglion P2X3 neuron"

nodose ganglion PVALB neuron http://purl.obolibrary.org/obo/CL_4033151

Added

• nodose ganglion PVALB neuron hasExactSynonym "inferior vagus X ganglion PVALB neuron"

nodose ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4033148

Added

• nodose ganglion TRPV1 neuron hasExactSynonym "inferior vagus X ganglion TRPV1 neuron"

nodose ganglion TRPV2 neuron http://purl.obolibrary.org/obo/CL_4033150

Added

• nodose ganglion TRPV2 neuron hasExactSynonym "inferior vagus X ganglion TRPV2 neuron"

otic ganglion VIP neuron http://purl.obolibrary.org/obo/CL_4033138

Removed

• otic ganglion VIP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• otic ganglion VIP neuron SubClassOf autonomic neuron

Added

• otic ganglion VIP neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the otic ganglion and expresses the marker vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• otic ganglion VIP neuron SubClassOf parasympathetic neuron

otic ganglion nNOS neuron http://purl.obolibrary.org/obo/CL_4033137

Removed

• otic ganglion nNOS neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the otic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• otic ganglion nNOS neuron SubClassOf autonomic neuron

Added

• otic ganglion nNOS neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the otic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• otic ganglion nNOS neuron SubClassOf parasympathetic neuron

ovarian nerve plexus ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033174

Removed

• ovarian nerve plexus ganglion TH neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the ovarian nerve plexus ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "doi:10.1111/joa.12436"

  • hasDbXref "FBC:Autogenerated"

• ovarian nerve plexus ganglion TH neuron SubClassOf BFO_0000002

• ovarian nerve plexus ganglion TH neuron SubClassOf peripheral nervous system neuron

Added

• ovarian nerve plexus ganglion TH neuron IAO_0000115 "A sympathetic neuron that has the soma located in the ovarian nerve plexus ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "doi:10.1111/joa.12436"

  • hasDbXref "FBC:Autogenerated"

• ovarian nerve plexus ganglion TH neuron SubClassOf sympathetic neuron

pelvic ganglion NPY/VAChT neuron http://purl.obolibrary.org/obo/CL_4033172

Removed

• pelvic ganglion NPY/VAChT neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuropeptide Y (NPY) and vesicular acetylcholine transporter (VAChT)."

  • hasDbXref "doi:10.1002/(SICI)1520-6777(2000)19:2%3C185::AID-NAU9%3E3.0.CO;2-2"

  • hasDbXref "FBC:Autogenerated"

• pelvic ganglion NPY/VAChT neuron SubClassOf autonomic neuron

Added

• pelvic ganglion NPY/VAChT neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuropeptide Y (NPY) and vesicular acetylcholine transporter (VAChT)."

  • hasDbXref "doi:10.1002/(SICI)1520-6777(2000)19:2%3C185::AID-NAU9%3E3.0.CO;2-2"

  • hasDbXref "FBC:Autogenerated"

• pelvic ganglion NPY/VAChT neuron SubClassOf parasympathetic neuron

pelvic ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033167

Removed

• pelvic ganglion TH neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "doi:10.1016/j.eururo.2005.02.010"

  • hasDbXref "doi:10.1186/s12894-018-0369-9"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1111/j.1469-7580.2009.01071.x"

• pelvic ganglion TH neuron SubClassOf autonomic neuron

Added

• pelvic ganglion TH neuron IAO_0000115 "A sympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "doi:10.1016/j.eururo.2005.02.010"

  • hasDbXref "doi:10.1186/s12894-018-0369-9"

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1111/j.1469-7580.2009.01071.x"

• pelvic ganglion TH neuron SubClassOf sympathetic neuron

pelvic ganglion TH/DBH neuron http://purl.obolibrary.org/obo/CL_4033168

Removed

• pelvic ganglion TH/DBH neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1007/s00441-020-03279-6"

• pelvic ganglion TH/DBH neuron SubClassOf autonomic neuron

Added

• pelvic ganglion TH/DBH neuron IAO_0000115 "A sympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1007/s00441-020-03279-6"

• pelvic ganglion TH/DBH neuron SubClassOf sympathetic neuron

pelvic ganglion VAChT neuron http://purl.obolibrary.org/obo/CL_4033169

Removed

• pelvic ganglion VAChT neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1111/j.1469-7580.2009.01071.x"

• pelvic ganglion VAChT neuron SubClassOf autonomic neuron

Added

• pelvic ganglion VAChT neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker vesicular acetylcholine transporter (VAChT)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1111/j.1469-7580.2009.01071.x"

• pelvic ganglion VAChT neuron SubClassOf parasympathetic neuron

pelvic ganglion nNOS neuron http://purl.obolibrary.org/obo/CL_4033170

Removed

• pelvic ganglion nNOS neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "doi:10.1002/(SICI)1520-6777(2000)19:2%3C185::AID-NAU9%3E3.0.CO;2-2"

  • hasDbXref "doi:10.1186/s12894-018-0369-9"

  • hasDbXref "FBC:Autogenerated"

• pelvic ganglion nNOS neuron SubClassOf autonomic neuron

Added

• pelvic ganglion nNOS neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "doi:10.1002/(SICI)1520-6777(2000)19:2%3C185::AID-NAU9%3E3.0.CO;2-2"

  • hasDbXref "doi:10.1186/s12894-018-0369-9"

  • hasDbXref "FBC:Autogenerated"

• pelvic ganglion nNOS neuron SubClassOf parasympathetic neuron

pelvic ganglion nNOS/VAChT neuron http://purl.obolibrary.org/obo/CL_4033173

Removed

• pelvic ganglion nNOS/VAChT neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1(nNOS) and vesicular acetylcholine transporter (VAChT)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/(SICI)1520-6777(2000)19:2<185::AID-NAU9>3.0.CO;2-2"

• pelvic ganglion nNOS/VAChT neuron SubClassOf autonomic neuron

Added

• pelvic ganglion nNOS/VAChT neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase 1(nNOS) and vesicular acetylcholine transporter (VAChT)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/(SICI)1520-6777(2000)19:2<185::AID-NAU9>3.0.CO;2-2"

• pelvic ganglion nNOS/VAChT neuron SubClassOf parasympathetic neuron

pelvic ganglion nNOS/VIP neuron http://purl.obolibrary.org/obo/CL_4033171

Removed

• pelvic ganglion nNOS/VIP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase (nNOS) 1 and vasoactive intestinal peptide (VIP)."

  • hasDbXref "doi:10.1186/s12894-018-0369-9"

  • hasDbXref "FBC:Autogenerated"

• pelvic ganglion nNOS/VIP neuron SubClassOf autonomic neuron

Added

• pelvic ganglion nNOS/VIP neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pelvic ganglion and expresses the marker neuronal nitric oxide synthase (nNOS) 1 and vasoactive intestinal peptide (VIP)."

  • hasDbXref "doi:10.1186/s12894-018-0369-9"

  • hasDbXref "FBC:Autogenerated"

• pelvic ganglion nNOS/VIP neuron SubClassOf parasympathetic neuron

pterygopalatine ganglion VIP neuron http://purl.obolibrary.org/obo/CL_4033145

Removed

• pterygopalatine ganglion VIP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• pterygopalatine ganglion VIP neuron SubClassOf autonomic neuron

Added

• pterygopalatine ganglion VIP neuron hasExactSynonym "sphenopalatine ganglion VIP neuron"

• pterygopalatine ganglion VIP neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• pterygopalatine ganglion VIP neuron SubClassOf parasympathetic neuron

pterygopalatine ganglion VIP/PHI neuron http://purl.obolibrary.org/obo/CL_4033144

Removed

• pterygopalatine ganglion VIP/PHI neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• pterygopalatine ganglion VIP/PHI neuron SubClassOf autonomic neuron

Added

• pterygopalatine ganglion VIP/PHI neuron hasExactSynonym "sphenopalatine ganglion VIP/PHI neuron"

• pterygopalatine ganglion VIP/PHI neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pterygopalatine ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• pterygopalatine ganglion VIP/PHI neuron SubClassOf parasympathetic neuron

pterygopalatine ganglion nNOS neuron http://purl.obolibrary.org/obo/CL_4033146

Removed

• pterygopalatine ganglion nNOS neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the pterygopalatine ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• pterygopalatine ganglion nNOS neuron SubClassOf autonomic neuron

Added

• pterygopalatine ganglion nNOS neuron hasExactSynonym "sphenopalatine ganglion nNOS neuron"

• pterygopalatine ganglion nNOS neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the pterygopalatine ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

  • hasDbXref "doi:10.1016/S0006-8993(99)01260-3"

• pterygopalatine ganglion nNOS neuron SubClassOf parasympathetic neuron

sacral dorsal root ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4079020

Added

• Class: sacral dorsal root ganglion CGRP neuron

• sacral dorsal root ganglion CGRP neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion CGRP neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion CGRP neuron hasRelatedSynonym "peptidergic nociceptor"

• sacral dorsal root ganglion CGRP neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

  • hasDbXref "PMID:29229553"

• sacral dorsal root ganglion CGRP neuron label "sacral dorsal root ganglion CGRP neuron"

• sacral dorsal root ganglion CGRP neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion CGRP neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion CGRP neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion CGRP neuron SubClassOf RO_0002292 some PR_000027226

sacral dorsal root ganglion Nav1.7 neuron http://purl.obolibrary.org/obo/CL_4079022

Added

• Class: sacral dorsal root ganglion Nav1.7 neuron

• sacral dorsal root ganglion Nav1.7 neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion Nav1.7 neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion Nav1.7 neuron IAO_0000115 "A nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• sacral dorsal root ganglion Nav1.7 neuron label "sacral dorsal root ganglion Nav1.7 neuron"

• sacral dorsal root ganglion Nav1.7 neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion Nav1.7 neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002292 some PR_000002104

sacral dorsal root ganglion Nav1.9 neuron http://purl.obolibrary.org/obo/CL_4079023

Added

• Class: sacral dorsal root ganglion Nav1.9 neuron

• sacral dorsal root ganglion Nav1.9 neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion Nav1.9 neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion Nav1.9 neuron IAO_0000115 "A nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1016/S0166-2236(02)02150-1"

  • hasDbXref "PMID:29229553"

• sacral dorsal root ganglion Nav1.9 neuron label "sacral dorsal root ganglion Nav1.9 neuron"

• sacral dorsal root ganglion Nav1.9 neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion Nav1.9 neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002292 some PR_000002097

sacral dorsal root ganglion Piezo2 neuron http://purl.obolibrary.org/obo/CL_4079025

Added

• Class: sacral dorsal root ganglion Piezo2 neuron

• sacral dorsal root ganglion Piezo2 neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion Piezo2 neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion Piezo2 neuron hasRelatedSynonym "mechanosensitive DRG neuron"

• sacral dorsal root ganglion Piezo2 neuron IAO_0000115 "A mechanosensitive sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• sacral dorsal root ganglion Piezo2 neuron label "sacral dorsal root ganglion Piezo2 neuron"

• sacral dorsal root ganglion Piezo2 neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion Piezo2 neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion Piezo2 neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion Piezo2 neuron SubClassOf RO_0002292 some PR_000032708

sacral dorsal root ganglion RET neuron http://purl.obolibrary.org/obo/CL_4079026

Added

• Class: sacral dorsal root ganglion RET neuron

• sacral dorsal root ganglion RET neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion RET neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion RET neuron hasRelatedSynonym "non-peptidergic nociceptor"

• sacral dorsal root ganglion RET neuron IAO_0000115 "A non-peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• sacral dorsal root ganglion RET neuron label "sacral dorsal root ganglion RET neuron"

• sacral dorsal root ganglion RET neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion RET neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion RET neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion RET neuron SubClassOf RO_0002292 some PR_000013895

sacral dorsal root ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4079028

Added

• Class: sacral dorsal root ganglion TRPV1 neuron

• sacral dorsal root ganglion TRPV1 neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion TRPV1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion TRPV1 neuron hasRelatedSynonym "capsaicin-sensitive nociceptor"

• sacral dorsal root ganglion TRPV1 neuron IAO_0000115 "A polymodal nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• sacral dorsal root ganglion TRPV1 neuron label "sacral dorsal root ganglion TRPV1 neuron"

• sacral dorsal root ganglion TRPV1 neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion TRPV1 neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion TRPV1 neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion TRPV1 neuron SubClassOf RO_0002292 some PR_000001065

sacral dorsal root ganglion endothelin-1 neuron http://purl.obolibrary.org/obo/CL_4079021

Added

• Class: sacral dorsal root ganglion endothelin-1 neuron

• sacral dorsal root ganglion endothelin-1 neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion endothelin-1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion endothelin-1 neuron hasExactSynonym "sacral dorsal root ganglion Endothelin 1 neuron"

• sacral dorsal root ganglion endothelin-1 neuron hasRelatedSynonym "EDN1 neuron"

• sacral dorsal root ganglion endothelin-1 neuron IAO_0000115 "A sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."

  • hasDbXref "10.1073/pnas.86.19.7634"

• sacral dorsal root ganglion endothelin-1 neuron label "sacral dorsal root ganglion endothelin-1 neuron"

• sacral dorsal root ganglion endothelin-1 neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion endothelin-1 neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002292 some PR_000006897

sacral dorsal root ganglion peripherin neuron http://purl.obolibrary.org/obo/CL_4079024

Added

• Class: sacral dorsal root ganglion peripherin neuron

• sacral dorsal root ganglion peripherin neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion peripherin neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion peripherin neuron hasExactSynonym "sacral dorsal root ganglion Peripherin neuron"

• sacral dorsal root ganglion peripherin neuron hasRelatedSynonym "C-fiber neuron"

• sacral dorsal root ganglion peripherin neuron IAO_0000115 "A small-diameter sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:31293388"

• sacral dorsal root ganglion peripherin neuron label "sacral dorsal root ganglion peripherin neuron"

• sacral dorsal root ganglion peripherin neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion peripherin neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion peripherin neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion peripherin neuron SubClassOf RO_0002292 some PR_000013289

sacral dorsal root ganglion substance P neuron http://purl.obolibrary.org/obo/CL_4079027

Added

• Class: sacral dorsal root ganglion substance P neuron

• sacral dorsal root ganglion substance P neuron contributor 0000-0001-6677-8489

• sacral dorsal root ganglion substance P neuron date "2026-03-13T11:13:54Z"^^dateTime

• sacral dorsal root ganglion substance P neuron hasExactSynonym "sacral dorsal root ganglion SP neuron"

• sacral dorsal root ganglion substance P neuron hasRelatedSynonym "SP neuron"

• sacral dorsal root ganglion substance P neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

• sacral dorsal root ganglion substance P neuron label "sacral dorsal root ganglion substance P neuron"

• sacral dorsal root ganglion substance P neuron SubClassOf BFO_0000002

• sacral dorsal root ganglion substance P neuron SubClassOf sensory neuron of dorsal root ganglion

• sacral dorsal root ganglion substance P neuron SubClassOf RO_0002100 some UBERON_0002837

• sacral dorsal root ganglion substance P neuron SubClassOf RO_0002292 some PR_000016003

submandibular ganglion TH cholinergic neuron http://purl.obolibrary.org/obo/CL_4033141

Removed

• submandibular ganglion TH cholinergic neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• submandibular ganglion TH cholinergic neuron SubClassOf autonomic neuron

Added

• submandibular ganglion TH cholinergic neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the submandibular ganglion and expresses the marker tyrosine hydroxylase (TH)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• submandibular ganglion TH cholinergic neuron SubClassOf parasympathetic neuron

submandibular ganglion VIP/PHI neuron http://purl.obolibrary.org/obo/CL_4033142

Removed

• submandibular ganglion VIP/PHI neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• submandibular ganglion VIP/PHI neuron SubClassOf autonomic neuron

Added

• submandibular ganglion VIP/PHI neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the submandibular ganglion and expresses the marker vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• submandibular ganglion VIP/PHI neuron SubClassOf parasympathetic neuron

submandibular ganglion nNOS neuron http://purl.obolibrary.org/obo/CL_4033143

Removed

• submandibular ganglion nNOS neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the submandibular ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• submandibular ganglion nNOS neuron SubClassOf autonomic neuron

Added

• submandibular ganglion nNOS neuron IAO_0000115 "A parasympathetic neuron that has the soma located in the submandibular ganglion and expresses the marker neuronal nitric oxide synthase 1 (nNOS)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.1002/ar.21516"

• submandibular ganglion nNOS neuron SubClassOf parasympathetic neuron

superior cervical ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4033107

Added

• superior cervical ganglion CGRP neuron hasExactSynonym "SCG CGRP neuron"

superior cervical ganglion NPY neuron http://purl.obolibrary.org/obo/CL_4033103

Added

• superior cervical ganglion NPY neuron hasExactSynonym "SCG NPY neuron"

superior cervical ganglion SST neuron http://purl.obolibrary.org/obo/CL_4033105

Added

• superior cervical ganglion SST neuron hasExactSynonym "SCG SST neuron"

superior cervical ganglion TH neuron http://purl.obolibrary.org/obo/CL_4033102

Added

• superior cervical ganglion TH neuron hasExactSynonym "SCG TH neuron"

superior cervical ganglion TH/DBH neuron http://purl.obolibrary.org/obo/CL_4033101

Added

• superior cervical ganglion TH/DBH neuron hasExactSynonym "SCG TH/DBH neuron"

superior cervical ganglion TH/NPY neuron http://purl.obolibrary.org/obo/CL_4033104

Added

• superior cervical ganglion TH/NPY neuron hasExactSynonym "SCG TH/NPY neuron"

superior cervical ganglion VIP neuron http://purl.obolibrary.org/obo/CL_4033106

Added

• superior cervical ganglion VIP neuron hasExactSynonym "SCG VIP neuron"

superior mesenteric ganglion SP neuron http://purl.obolibrary.org/obo/CL_4033134

Added

• superior mesenteric ganglion SP neuron hasExactSynonym "SMG SP neuron"

• superior mesenteric ganglion SP neuron SubClassOf RO_0002292 some PR_000016003

thoracic dorsal root ganglion CGRP neuron http://purl.obolibrary.org/obo/CL_4079029

Added

• Class: thoracic dorsal root ganglion CGRP neuron

• thoracic dorsal root ganglion CGRP neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion CGRP neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion CGRP neuron hasRelatedSynonym "peptidergic nociceptor"

• thoracic dorsal root ganglion CGRP neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553)."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

  • hasDbXref "PMID:29229553"

• thoracic dorsal root ganglion CGRP neuron label "thoracic dorsal root ganglion CGRP neuron"

• thoracic dorsal root ganglion CGRP neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion CGRP neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion CGRP neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion CGRP neuron SubClassOf RO_0002292 some PR_000027226

thoracic dorsal root ganglion Nav1.7 neuron http://purl.obolibrary.org/obo/CL_4079031

Added

• Class: thoracic dorsal root ganglion Nav1.7 neuron

• thoracic dorsal root ganglion Nav1.7 neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion Nav1.7 neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion Nav1.7 neuron IAO_0000115 "A nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.7 (encoded by SCN9A). This neuron is characterized by Nav1.7-dependent action potential initiation and amplification, which is essential for normal pain sensation in humans. Nav1.7 contributes approximately 50% of total sodium channel current in human DRG nociceptors (Chang et al. 2018, PMID:28424991). In human DRG, Nav1.7 immunoreactivity is detected in 54-57% of TrkA-positive neurons (Rostock et al. 2018, PMID:29229553). Human genetic evidence confirms Nav1.7 as necessary and sufficient for nociceptive function in these neurons."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• thoracic dorsal root ganglion Nav1.7 neuron label "thoracic dorsal root ganglion Nav1.7 neuron"

• thoracic dorsal root ganglion Nav1.7 neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion Nav1.7 neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion Nav1.7 neuron SubClassOf RO_0002292 some PR_000002104

thoracic dorsal root ganglion Nav1.9 neuron http://purl.obolibrary.org/obo/CL_4079032

Added

• Class: thoracic dorsal root ganglion Nav1.9 neuron

• thoracic dorsal root ganglion Nav1.9 neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion Nav1.9 neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion Nav1.9 neuron IAO_0000115 "A nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the voltage-gated sodium channel Nav1.9 (encoded by SCN11A). This neuron is characterized by a persistent, tetrodotoxin-resistant sodium current that modulates resting membrane potential and amplifies subthreshold depolarizations, contributing to enhanced excitability during inflammation (Dib-Hajj et al. 2002, PMID:11972962). In human DRG, Nav1.9-immunoreactive neurons constitute approximately 26% of TrkA-positive neurons, a significantly higher proportion than the 12% observed in mouse (Rostock et al. 2018, PMID:29229553), suggesting species differences in inflammatory pain processing."

  • hasDbXref "10.1038/nn.3602"

  • hasDbXref "10.1016/S0166-2236(02)02150-1"

  • hasDbXref "PMID:29229553"

• thoracic dorsal root ganglion Nav1.9 neuron label "thoracic dorsal root ganglion Nav1.9 neuron"

• thoracic dorsal root ganglion Nav1.9 neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion Nav1.9 neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion Nav1.9 neuron SubClassOf RO_0002292 some PR_000002097

thoracic dorsal root ganglion Piezo2 neuron http://purl.obolibrary.org/obo/CL_4079034

Added

• Class: thoracic dorsal root ganglion Piezo2 neuron

• thoracic dorsal root ganglion Piezo2 neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion Piezo2 neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion Piezo2 neuron hasRelatedSynonym "mechanosensitive DRG neuron"

• thoracic dorsal root ganglion Piezo2 neuron IAO_0000115 "A mechanosensitive sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• thoracic dorsal root ganglion Piezo2 neuron label "thoracic dorsal root ganglion Piezo2 neuron"

• thoracic dorsal root ganglion Piezo2 neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion Piezo2 neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion Piezo2 neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion Piezo2 neuron SubClassOf RO_0002292 some PR_000032708

thoracic dorsal root ganglion RET neuron http://purl.obolibrary.org/obo/CL_4079035

Added

• Class: thoracic dorsal root ganglion RET neuron

• thoracic dorsal root ganglion RET neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion RET neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion RET neuron hasRelatedSynonym "non-peptidergic nociceptor"

• thoracic dorsal root ganglion RET neuron IAO_0000115 "A non-peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "PMID:29229553"

• thoracic dorsal root ganglion RET neuron label "thoracic dorsal root ganglion RET neuron"

• thoracic dorsal root ganglion RET neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion RET neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion RET neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion RET neuron SubClassOf RO_0002292 some PR_000013895

thoracic dorsal root ganglion TRPV1 neuron http://purl.obolibrary.org/obo/CL_4079037

Added

• Class: thoracic dorsal root ganglion TRPV1 neuron

• thoracic dorsal root ganglion TRPV1 neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion TRPV1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion TRPV1 neuron hasRelatedSynonym "capsaicin-sensitive nociceptor"

• thoracic dorsal root ganglion TRPV1 neuron IAO_0000115 "A polymodal nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the transient receptor potential vanilloid 1 channel (TRPV1, encoded by TRPV1). This neuron detects noxious heat above 43 degrees Celsius, protons, and endogenous lipid mediators, and is activated by capsaicin. In human DRG, TRPV1-immunoreactive neurons constitute approximately 54% of TrkA-positive neurons, significantly higher than the 35% observed in mouse (Rostock et al. 2018, PMID:29229553). These neurons are predominantly small-diameter nociceptors that innervate skin and visceral organs, where they function as primary detectors of thermal and chemical noxious stimuli."

  • hasDbXref "10.1016/j.neuroscience.2017.11.047"

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:29229553"

• thoracic dorsal root ganglion TRPV1 neuron label "thoracic dorsal root ganglion TRPV1 neuron"

• thoracic dorsal root ganglion TRPV1 neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion TRPV1 neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion TRPV1 neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion TRPV1 neuron SubClassOf RO_0002292 some PR_000001065

thoracic dorsal root ganglion endothelin-1 neuron http://purl.obolibrary.org/obo/CL_4079030

Added

• Class: thoracic dorsal root ganglion endothelin-1 neuron

• thoracic dorsal root ganglion endothelin-1 neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion endothelin-1 neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion endothelin-1 neuron hasExactSynonym "thoracic dorsal root ganglion Endothelin 1 neuron"

• thoracic dorsal root ganglion endothelin-1 neuron hasRelatedSynonym "EDN1 neuron"

• thoracic dorsal root ganglion endothelin-1 neuron IAO_0000115 "A sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets."

  • hasDbXref "10.1073/pnas.86.19.7634"

• thoracic dorsal root ganglion endothelin-1 neuron label "thoracic dorsal root ganglion endothelin-1 neuron"

• thoracic dorsal root ganglion endothelin-1 neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion endothelin-1 neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion endothelin-1 neuron SubClassOf RO_0002292 some PR_000006897

thoracic dorsal root ganglion peripherin neuron http://purl.obolibrary.org/obo/CL_4079033

Added

• Class: thoracic dorsal root ganglion peripherin neuron

• thoracic dorsal root ganglion peripherin neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion peripherin neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion peripherin neuron hasExactSynonym "thoracic dorsal root ganglion Peripherin neuron"

• thoracic dorsal root ganglion peripherin neuron hasRelatedSynonym "C-fiber neuron"

• thoracic dorsal root ganglion peripherin neuron IAO_0000115 "A small-diameter sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons."

  • hasDbXref "10.1007/s12264-017-0132-3"

  • hasDbXref "PMID:31293388"

• thoracic dorsal root ganglion peripherin neuron label "thoracic dorsal root ganglion peripherin neuron"

• thoracic dorsal root ganglion peripherin neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion peripherin neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion peripherin neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion peripherin neuron SubClassOf RO_0002292 some PR_000013289

thoracic dorsal root ganglion substance P neuron http://purl.obolibrary.org/obo/CL_4079036

Added

• Class: thoracic dorsal root ganglion substance P neuron

• thoracic dorsal root ganglion substance P neuron contributor 0000-0001-6677-8489

• thoracic dorsal root ganglion substance P neuron date "2026-03-13T11:13:54Z"^^dateTime

• thoracic dorsal root ganglion substance P neuron hasExactSynonym "thoracic dorsal root ganglion SP neuron"

• thoracic dorsal root ganglion substance P neuron hasRelatedSynonym "SP neuron"

• thoracic dorsal root ganglion substance P neuron IAO_0000115 "A peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses substance P, an 11-amino-acid neuropeptide cleaved from protachykinin-1 (encoded by TAC1). This small-diameter neuron frequently co-expresses CGRP and belongs to the TrkA-positive peptidergic population. Upon nociceptive activation, it releases substance P both centrally in the spinal cord dorsal horn and peripherally at sensory nerve terminals, mediating neurogenic inflammation through NK1 receptor signalling (Haberberger et al. 2019, PMID:31293388). Substance P-immunoreactive neurons have been consistently identified in human DRG by immunohistochemistry across multiple studies."

  • hasDbXref "PMID:31293388"

  • hasDbXref "10.1016/S0304-3940(00)00772-2"

• thoracic dorsal root ganglion substance P neuron label "thoracic dorsal root ganglion substance P neuron"

• thoracic dorsal root ganglion substance P neuron SubClassOf BFO_0000002

• thoracic dorsal root ganglion substance P neuron SubClassOf sensory neuron of dorsal root ganglion

• thoracic dorsal root ganglion substance P neuron SubClassOf RO_0002100 some UBERON_0002835

• thoracic dorsal root ganglion substance P neuron SubClassOf RO_0002292 some PR_000016003

vestibular ganglion SP neuron http://purl.obolibrary.org/obo/CL_4033147

Removed

• vestibular ganglion SP neuron IAO_0000115 "A peripheral nervous system neuron that has the soma located in the vestibular ganglion and expresses the marker substance P (SP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.3109/00016489609137839"

• vestibular ganglion SP neuron SubClassOf peripheral nervous system neuron

Added

• vestibular ganglion SP neuron hasExactSynonym "Scarpa's ganglion SP neuron"

• vestibular ganglion SP neuron IAO_0000115 "A sensory neuron that has the soma located in the vestibular ganglion and expresses the marker substance P (SP)."

  • hasDbXref "FBC:Autogenerated"

  • hasDbXref "doi:10.3109/00016489609137839"

• vestibular ganglion SP neuron SubClassOf sensory neuron

• vestibular ganglion SP neuron SubClassOf RO_0002292 some PR_000016003

[github-actions]

Here's a diff of your edit file (unreasoned)

Ontologies are identical

[dosumis]

Looks good. we could have a second round where we make the sensory types more specific (I think we have nociceptive neuron and we should have if we don't)